CN108159167A - One kind is used to treat dark sore liniment and preparation method thereof - Google Patents
One kind is used to treat dark sore liniment and preparation method thereof Download PDFInfo
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- CN108159167A CN108159167A CN201810083319.3A CN201810083319A CN108159167A CN 108159167 A CN108159167 A CN 108159167A CN 201810083319 A CN201810083319 A CN 201810083319A CN 108159167 A CN108159167 A CN 108159167A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/22—Boron compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/30—Zinc; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/756—Phellodendron, e.g. corktree
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- Natural Medicines & Medicinal Plants (AREA)
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- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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- Mycology (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
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- Chemical Kinetics & Catalysis (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention discloses one kind for treating dark sore liniment, proportion is including formula composition and by weight：23.8 parts by weight of calamine stone, 7.1 parts by weight of boric acid powder, 3.5 parts by weight of resorcinol powder, 1.2 parts by weight of vitamin c powder, 23.8 parts by weight of oxide powder and zinc, settle 5.9 parts by weight of sulphur powder, 0.9 parts by weight of chlormycetin powder, 2.8 parts by weight of alumen powder, 0.7 parts by weight of the coptis, 0.7 parts by weight of Cortex Phellodendri, 29.6 parts by weight of glycerine, added in during this kind is used to treating the preparation method of dark sore liniment vitamin C as antioxidant avoid liniment in resorcinol powder because of poor chemical stability, it reduces the overall stability of suspension liquid preparation and affects the treatment, and it is prepared separately for ingredient in formula, method is proper, improve the stability of dark sore liniment.
Description
Technical field
It is specifically a kind of to be used to treat dark sore liniment and preparation method thereof the present invention relates to liniment field.
Background technology
Dark sore liniment is a kind of very extensive external application suspension type liquid formulation of clinical practice, significant in efficacy.But due to it
Contained drug comparison of ingredients is more, and particularly some of which Components Chemical stability is poor, and since this preparation belongs to thermodynamics not
Stable coarse dispersion system causes the preparation stored time short, if the preparation method of preparation is easy to malfunction, will necessarily reduce stabilization
Property and affect the treatment.
Invention content
The purpose of the present invention is to provide one kind for treating dark sore liniment and preparation method thereof, to solve above-mentioned background skill
The problem of being proposed in art.
To achieve the above object, the present invention provides following technical solution：
One kind is for treating dark sore liniment, and proportion is including formula composition and by weight：23.8 parts by weight of calamine stone, boric acid powder
7.1 parts by weight, 3.5 parts by weight of resorcinol powder, 1.2 parts by weight of vitamin c powder, 23.8 parts by weight of oxide powder and zinc, sedimentation sulphur powder
5.9 parts by weight, 0.9 parts by weight of chlormycetin powder, 2.8 parts by weight of alumen powder, 0.7 parts by weight of the coptis, 0.7 parts by weight of Cortex Phellodendri, glycerine
29.6 parts by weight.
It is a kind of to include the following steps for treating the preparation method of dark sore liniment：
S1, the calamine stone of 23.8 parts by weight and the oxide powder and zinc of 23.8 parts by weight that will be sieved by 200 mesh, are poured into equipped with distillation
In the container of water, with distilled water immersion 3-4h, make medicinal powder slowly water swelling, in last all sinkings water after, add in 15 weight
The glycerine of part, is rapidly stirred with blender；
S2, the boric acid of 7.1 parts by weight is taken to be dissolved with hot distilled water, places cooling, take the cold distillation of vitamin C of 1.2 parts by weight
Water dissolution, for use；
The resorcinol powder of S3, the chlormycetin powder for taking 0.9 parts by weight and 3.5 parts by weight are placed in container, are separately added by feed liquid
Weight ratio 1:50 95% ethyl alcohol dissolving, for use；
S4, the coptis for taking 0.7 parts by weight, 0.7 parts by weight Cortex Phellodendri, be ground to 200 mesh of powder hereinafter, adding in equipped with distilled water
In container, the alumen powder of 2.8 parts by weight of 200 mesh sieve was stirring evenly and then adding into, it is for use after being sufficiently stirred；
S5, the glycerine equipped with 10 parts by weight will be poured by the sedimentation sulphur powder of 5.9 parts by weight of 200 mesh sieve, slowly stirred to complete
Portion's medicinal powder is rapidly stirred after being soaked by glycerine with blender again；
S6, prepared sedimentation sulphur solution is poured into the liquid containing calamine and zinc oxide, then pour into remaining glycerine, with stirring
After machine rapidly stirs 30min, chloromycetin solution, boric acid solution and the mixed solution containing the coptis, Cortex Phellodendri and alumen are poured into successively
It slowly stirs, is eventually adding resorcinol alcoholic solution and vitamin C aqueous solution, it is 1 to add material liquid volume ratio:20 95% second
Alcohol to get.
As further embodiment of the present invention：In the S1 steps in container the amount of distilled water just submerge calamine stone and
Oxide powder and zinc.
As further embodiment of the present invention：Resorcinol powder selects raw material color as white in the S3 steps.
As further embodiment of the present invention：The sodium bicarbonate solution of 1.5mol/L is added in after the S6 steps, adjusts medicine
Liquid pH value is 7.
Compared with prior art, the beneficial effects of the invention are as follows：In this kind for treating the preparation method of dark sore liniment in
Addition vitamin C avoids resorcinol powder in liniment as antioxidant, because of poor chemical stability, reduces suspension liquid preparation
Overall stability and affect the treatment, and for formula in ingredient be prepared separately, method is proper, improves the stabilization of dark sore liniment
Property.
Specific embodiment
The technical solution in the embodiment of the present invention is clearly and completely described below, it is clear that described embodiment
Only part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, the common skill in this field
Art personnel all other embodiments obtained without making creative work belong to the model that the present invention protects
It encloses.
One kind is for treating dark sore liniment, and proportion is including formula composition and by weight：23.8 parts by weight of calamine stone, boron
Sour 7.1 parts by weight of powder, 3.5 parts by weight of resorcinol powder, 1.2 parts by weight of vitamin c powder, 23.8 parts by weight of oxide powder and zinc, sedimentation
5.9 parts by weight of sulphur powder, 0.9 parts by weight of chlormycetin powder, 2.8 parts by weight of alumen powder, 0.7 parts by weight of the coptis, 0.7 parts by weight of Cortex Phellodendri,
29.6 parts by weight of glycerine.
It is a kind of to include the following steps for treating the preparation method of dark sore liniment：
S1, the calamine stone of 23.8 parts by weight and the oxide powder and zinc of 23.8 parts by weight that will be sieved by 200 mesh, are poured into equipped with distillation
In the container of water, with distilled water immersion 3-4h, make medicinal powder slowly water swelling, in last all sinkings water after, add in 15 weight
The glycerine of part, is rapidly stirred with blender, can be made drug granule exquisiteness, is uniformly dispersed；
S2, the boric acid of 7.1 parts by weight is taken to be dissolved with hot distilled water, places cooling, take the cold distillation of vitamin C of 1.2 parts by weight
Water dissolution, for use；
The resorcinol powder of S3, the chlormycetin powder for taking 0.9 parts by weight and 3.5 parts by weight are placed in container, are separately added by feed liquid
Weight ratio 1:50 95% ethyl alcohol dissolving, for use；
S4, the coptis for taking 0.7 parts by weight, 0.7 parts by weight Cortex Phellodendri, be ground to 200 mesh of powder hereinafter, adding in equipped with distilled water
In container, the alumen powder of 2.8 parts by weight of 200 mesh sieve was stirring evenly and then adding into, it is for use after being sufficiently stirred；
S5, the glycerine equipped with 10 parts by weight will be poured by the sedimentation sulphur powder of 5.9 parts by weight of 200 mesh sieve, slowly stirred to complete
Portion's medicinal powder is rapidly stirred after being soaked by glycerine with blender again；
S6, prepared sedimentation sulphur solution is poured into the liquid containing calamine and zinc oxide, then pour into remaining glycerine, with stirring
After machine rapidly stirs 30min, chloromycetin solution, boric acid solution and the mixed solution containing the coptis, Cortex Phellodendri and alumen are poured into successively
It slowly stirs, is eventually adding resorcinol alcoholic solution and vitamin C aqueous solution, it is 1 to add material liquid volume ratio:20 95% second
The liquid prepared to get and being packed into the closed container for hiding color, be placed in the storage of cool dark place by alcohol.
The amount of distilled water just submerges calamine stone and oxide powder and zinc in container in the S1 steps.
Resorcinol powder selects raw material color as white in the S3 steps.
The sodium bicarbonate solution of 1.5mol/L is added in after the S6 steps, regulating liquid medicine pH value is 7.
Preparation method explanation：
In the dissolving of S2 step boric acid powders, because the synthermal size positive correlation of the solubility of boric acid, then water-soluble using thermal distillation
Solution, but the liquid that is made into such as need could be mixed after letting cool with other drugs, reason is the raising of fluid temperature, can not only influence
The chemical property of some drugs in preparation such as accelerates the discoloration of resorcinol, can also change the sedimentation of suspension drug particles
Speed, flocculation rate, sedimentation volumn, so as to change its stability.
Because resorcinol is a kind of Strong oxdiative object, oxidation reaction occurs under the action of oxygen or heavy metal in Yi Guang, air
Generation quinone and make color become pink, and with the time extension its darken, and make liquid property unstable, then with
During system, add in vitamin C and make antioxidant.
It is obvious to a person skilled in the art that the present invention is not limited to the details of above-mentioned exemplary embodiment, Er Qie
In the case of without departing substantially from spirit or essential attributes of the invention, the present invention can be realized in other specific forms.Therefore, no matter
From the point of view of which point, the present embodiments are to be considered as illustrative and not restrictive, and the scope of the present invention is by appended power
Profit requirement rather than above description limit, it is intended that all by what is fallen within the meaning and scope of the equivalent requirements of the claims
Variation is included within the present invention.
In addition, it should be understood that although this specification is described in terms of embodiments, but not each embodiment is only wrapped
Containing an independent technical solution, this description of the specification is merely for the sake of clarity, and those skilled in the art should
It considers the specification as a whole, the technical solutions in each embodiment can also be properly combined, forms those skilled in the art
The other embodiment being appreciated that.
Claims (5)
1. one kind is for treating dark sore liniment, which is characterized in that proportion is including formula composition and by weight：Calamine stone 23.8
Parts by weight, 7.1 parts by weight of boric acid powder, 3.5 parts by weight of resorcinol powder, 1.2 parts by weight of vitamin c powder, 23.8 weight of oxide powder and zinc
Measure part, 5.9 parts by weight of sedimentation sulphur powder, 0.9 parts by weight of chlormycetin powder, 2.8 parts by weight of alumen powder, 0.7 parts by weight of the coptis, Cortex Phellodendri
0.7 parts by weight, 29.6 parts by weight of glycerine.
2. one kind according to claim 1 is used to treat dark sore liniment, which is characterized in that the preparation side of the dark sore liniment
Method includes the following steps：
S1, the calamine stone of 23.8 parts by weight and the oxide powder and zinc of 23.8 parts by weight that will be sieved by 200 mesh, are poured into equipped with distillation
In the container of water, with distilled water immersion 3-4h, make medicinal powder slowly water swelling, in last all sinkings water after, add in 15 weight
The glycerine of part, is rapidly stirred with blender；
S2, the boric acid of 7.1 parts by weight is taken to be dissolved with hot distilled water, places cooling, take the cold distillation of vitamin C of 1.2 parts by weight
Water dissolution, for use；
The resorcinol powder of S3, the chlormycetin powder for taking 0.9 parts by weight and 3.5 parts by weight are placed in container, are separately added by feed liquid
Weight ratio 1:50 95% ethyl alcohol dissolving, for use；
S4, the coptis for taking 0.7 parts by weight, 0.7 parts by weight Cortex Phellodendri, be ground to 200 mesh of powder hereinafter, adding in equipped with distilled water
In container, the alumen powder of 2.8 parts by weight of 200 mesh sieve was stirring evenly and then adding into, it is for use after being sufficiently stirred；
S5, the glycerine equipped with 10 parts by weight will be poured by the sedimentation sulphur powder of 5.9 parts by weight of 200 mesh sieve, slowly stirred to complete
Portion's medicinal powder is rapidly stirred after being soaked by glycerine with blender again；
S6, prepared sedimentation sulphur solution is poured into the liquid containing calamine and zinc oxide, then pour into remaining glycerine, with stirring
After machine rapidly stirs 30min, chloromycetin solution, boric acid solution and the mixed solution containing the coptis, Cortex Phellodendri and alumen are poured into successively
It slowly stirs, is eventually adding resorcinol alcoholic solution and vitamin C aqueous solution, it is 1 to add material liquid volume ratio:20 95% second
Alcohol to get.
3. one kind according to claim 2 is used to treat dark sore liniment preparation method, which is characterized in that in the S1 steps
The amount of distilled water just submerges calamine stone and oxide powder and zinc in container.
4. one kind according to claim 2 is used to treat dark sore liniment preparation method, which is characterized in that in the S3 steps
Resorcinol powder selects raw material color as white.
5. one kind according to claim 2 is used to treat dark sore liniment preparation method, which is characterized in that after the S6 steps
The sodium bicarbonate solution of 1.5mol/L is added in, regulating liquid medicine pH value is 7.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810083319.3A CN108159167A (en) | 2018-01-29 | 2018-01-29 | One kind is used to treat dark sore liniment and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810083319.3A CN108159167A (en) | 2018-01-29 | 2018-01-29 | One kind is used to treat dark sore liniment and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108159167A true CN108159167A (en) | 2018-06-15 |
Family
ID=62515790
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810083319.3A Withdrawn CN108159167A (en) | 2018-01-29 | 2018-01-29 | One kind is used to treat dark sore liniment and preparation method thereof |
Country Status (1)
| Country | Link |
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| CN (1) | CN108159167A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110339089A (en) * | 2019-08-22 | 2019-10-18 | 上海奇良生物科技有限公司 | Lotion is smeared in a kind of external application of the antibacterial smelly anti-drying peeling of dispelling of strength hidroschesis |
-
2018
- 2018-01-29 CN CN201810083319.3A patent/CN108159167A/en not_active Withdrawn
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110339089A (en) * | 2019-08-22 | 2019-10-18 | 上海奇良生物科技有限公司 | Lotion is smeared in a kind of external application of the antibacterial smelly anti-drying peeling of dispelling of strength hidroschesis |
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Application publication date: 20180615 |
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