CN109528537A - A kind of water-soluble nail product and preparation method thereof prevented and/or treat onychomycosis - Google Patents
A kind of water-soluble nail product and preparation method thereof prevented and/or treat onychomycosis Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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Abstract
The invention discloses a kind of prevention and/or the water-soluble nail products and preparation method thereof for the treatment of onychomycosis, belong to beauty, health care preparation field.Nail-care products principle active component of the invention is jamaicin, coptis extract, phellodendron extract, Radix Berberidis extract or SHIDAGONGLAO extract, yellow pigment can be belonged to again as antimicrobial component, have many advantages, such as also to have both prevention while manicure and/or treat the double effects of onychomycosis, with high security, environmentally protective and easy to clean.The present invention also provides a kind of process flow is simple, a kind of method of the water-soluble nail product for preparing prevention and/or treatment onychomycosis of easy-to-operate.
Description
Technical field
The invention belongs to beauty, health care preparation field, and in particular to a kind of water-soluble plukenetia prevented and/or treat onychomycosis
First product and preparation method thereof.
Background technique
Now widely used nail-care products are mainly nail polish, mostly oily molten in order to pursue film forming and smear conveniently
Property, contain the ingredient unfavorable to health, such as synthetic dyestuff, toxic mineral pigment, oil-based solvent and synthetic resin.Some refer to
Nail polish joined the volatile components such as a large amount of ethyl acetate, ethyl butyrate, acetone to realize the purpose quickly parched, this
A little irritant smells of volatile solvent, when high concentration, make one dizziness, vomiting and intense stimulus mucous membrane.Oil-soluble nail polish it is another
An outer defect is to remove difficulty, it is necessary to wash nail polish using dedicated, also be harmful to human health.Since cleaning is difficult, secondary colour
Element can be also slowly attached on nail, hindered the eupnea of nail, be unfavorable for the normal growth of nail horn cell, nail meeting
It is more and more thinner, it easily snaps off and slow growth.It can be seen that using natural pigment (number of patent application
CN201810112615.1), the nail polish of water-soluble base (CN201810031087.7) is the following green and healthy nail polish
It pursues.
Onychomycosis is by the fungus-caused chronic infective onychonosus of the first such as dermatophyte, saccharomycete, and modern medicine is referred to as
Onychomycosis is a kind of with communicable common disease, frequently-occurring disease.Currently, the drug for the treatment of first fungi is mostly antimycotic antibiosis
Element and chemotherapeutic drug, not only treatment is not thorough, and how much all there is the different degrees of damage to skin, and some also causes seriously
Liver, renal damage.Although Chinese medicine, which treats onychomycosis effect, is not so good as Western medicine, comparatively almost without what side effect.It controls
Treatment onychomycosis effect is relatively good, and the specific Chinese medicine of effective component mainly has the coptis, Cortex Phellodendri, barberry and Chinese mahonia, function
Effect ingredient is berberine Alkaloid, the use of dosage form is mostly the aqua containing acetic acid, and usage mode is to smear affected part.In this aqua
Acetic acid, volatilized after smearing quickly, be unfavorable for the performance of drug effect, while generating penetrating odor.
In view of this, the present invention provides a kind of water-soluble nail product that can prevent and treat onychomycosis, beauty is being enjoyed
Onychomycosis can be prevented and treated simultaneously.The nail-care products derive from cloud from natural plants, inorganic pigment using organic pigment
Female mine, membrane material are edible glue, and solvent is water, therefore product safety rank is high, is easy to remove, and not only manicure but also have prevented onychomycosis.
Summary of the invention
In view of this, one of the objects of the present invention is to provide a kind of prevention and/or the water-soluble nails for the treatment of onychomycosis
Product；The second object of the present invention is to provide the preparation side of a kind of prevention and/or the water-soluble nail product for treating onychomycosis
Method.
For achieving the above object, the invention provides the following technical scheme:
1, the water-soluble nail product of a kind of prevention and/or treatment onychomycosis, the nail-care products include effective component, resist
Bacterium inflammation-diminishing function ingredient, coalescing agent, film forming agent, colour generation reinforcing agent and water, the nail-care products are water solubility, the manicure
Product has the function of preventing and/or treating onychomycosis.
Preferably, the effective component include jamaicin, coptis extract, phellodendron extract, Radix Berberidis extract or
Any one or more in SHIDAGONGLAO extract；The antibacterial anti-inflammatory functional component is by sodium benzoate, sodium salicylate and second
Sour sodium composition, the water are distilled water or deionized water；The coalescing agent be gelatin, seaweed glue, Arabic gum, pectin or
One of person's xanthan gum is a variety of；The coalescing agent is at least one of glycerol or ethylene glycol；The colour generation enhancing
Agent is at least one of nacreous mica powder or pearly-lustre gold.
Further, the mass fraction of effective component described in the nail-care products is 1~5%, the antibacterial anti-inflammatory function
The mass fraction of ingredient is 1.8~4%, and the mass fraction of the coalescing agent is 10~12%, the quality point of the film forming agent
Number is 1.0~15%, and the mass fraction of the colour generation reinforcing agent is 2~5%.
2, the preparation method of the water-soluble nail product of a kind of above-mentioned prevention and/or treatment onychomycosis, the method are specific
It operates as follows:
(1) by mass fraction be 1~5% effective component, mass fraction be 1.8~4% antibacterial anti-inflammatory functional component
It is placed in same container, coalescing agent and the water that mass fraction is 10~12% is added, heating maintains temperature in 40~65 DEG C of items
Under part, stir to being completely dissolved, as solution I；
(2) film forming agent that mass fraction is 1.0~15% is placed in another container, is heated to 60~85 DEG C, stirring is extremely
After being completely dissolved, taking-up is cooled to 40~55 DEG C as solution II；
(3) solution I in step (1) is slowly added in the solution II in step (2) by several times, stirring while adding, mixing
Uniformly after be added 2~5% colour generation reinforcing agent, continue stirring until be uniformly mixed can be obtained it is a kind of prevention and/or treatment ash
The water-soluble nail product of nail.
Preferably, effective component described in step (1) is jamaicin, coptis extract, phellodendron extract, radix berberidis extraction
Object or SHIDAGONGLAO extract, water are distilled water or deionized water.
Preferably, the antibacterial anti-inflammatory functional component is made of sodium benzoate, sodium salicylate and sodium acetate.
Preferably, which is characterized in that the film forming agent is in gelatin, seaweed glue, Arabic gum, pectin or xanthan gum
It is one or more.
Preferably, the coalescing agent is at least one of glycerol or ethylene glycol.
Preferably, the colour generation reinforcing agent is at least one of nacreous mica powder or pearly-lustre gold.
The beneficial effects of the present invention are:
1, the invention discloses a kind of prevention and/or the water-soluble nail products for the treatment of onychomycosis, with manicure function
Prevention is also had both simultaneously and/or treats the double effects of onychomycosis, with high security, environmentally protective and easy to clean etc. excellent
Point, principle active component therein are jamaicin, coptis extract, phellodendron extract, Radix Berberidis extract or Chinese mahonia
Extract is both that can belong to again yellow pigment as antimicrobial component.
2, the present invention discloses it is a kind of prevention and/or treatment onychomycosis water-soluble nail product preparation method,
Process flow is simple, safe operation.
Specific embodiment
Below by a preferred embodiment of the present invention will be described in detail.The experiment of actual conditions is not specified in embodiment
Method, usually according to conventional conditions or according to the manufacturer's recommendations.
Embodiment 1
(1) effective component 5g (its Berberine 1g, coptis extract 1g, phellodendron extract 1g, Radix Berberidis extract are weighed
1g, SHIDAGONGLAO extract 1g) and antibacterial anti-inflammatory functional component 2.3g (wherein benzoic acid 0.8g, sodium acetate 0.5g, sodium salicylate
It 1g) is placed in 100ml beaker, adds glycerol 12g as coalescing agent, add distilled water 20ml, be heated to 40 under water bath condition
DEG C and keep the temperature, stirring is until be completely dissolved to obtain solution I；
(2) claim film forming agent 14.1g (wherein gelatin 14g, seaweed glue 0.1g) to be placed in 200ml beaker, distilled water is added
44.6ml is heated to 60 DEG C and keeps the temperature, and stirs to being completely dissolved, and is cooled to 40 DEG C and obtains solution II；
(3) solution I is slowly added into solution II in the state of being kept stirring, nacreous mica powder is added after mixing
2g continues to stir the water that a kind of prevention and/or treatment onychomycosis can be obtained until being mixed thoroughly as colour generation reinforcing agent
Dissolubility nail-care products.
Embodiment 2
(1) i.e. coptis extract 3g is weighed as effective component, antibacterial anti-inflammatory functional component 2.3g (wherein benzoic acid
0.8g, sodium acetate 0.5g, sodium salicylate 1g) it is placed in the beaker of 100ml with coalescing agent, that is, ethylene glycol 10g, add distilled water about
20ml is heated to 60 DEG C under water bath condition and keeps the temperature, and stirring is until be completely dissolved to obtain solution I；
(2) claim film forming agent 5.3g (wherein seaweed glue 5g, xanthan gum 0.3g) to be placed in the beaker of 200ml, 54.4ml is added
Distilled water, be heated to 75 DEG C and keep the temperature, stir to being completely dissolved, obtain solution II when being cooled to 55 DEG C；
(3) solution I is slowly added into solution II in the state of being kept stirring, pearly-lustre gold 5g is added after mixing and makees
For colour generation reinforcing agent, continue to stir the water solubility that a kind of prevention and/or treatment onychomycosis can be obtained until being mixed thoroughly
Nail-care products.
Embodiment 3
(1) effective component 4g (wherein phellodendron extract 3g, Radix Berberidis extract 1g), antibacterial anti-inflammatory functional component are weighed
2.3g (wherein benzoic acid 0.8g, sodium acetate 0.5g, sodium salicylate 1g) and coalescing agent 11g (wherein glycerol 8g, ethylene glycol 3g)
It is placed in the beaker of 100ml, distilled water about 20ml is added, is heated to 65 DEG C under water bath condition and keeps the temperature, stirring is until completely molten
Solve solution I；
(2) claim Arabic gum 15g to be placed in the beaker of 200ml as film forming agent, the deionized water of 44.7ml is added, heat
To 70 DEG C and continue to keep the temperature, stirs to being completely dissolved, obtain solution II when being cooled to 45 DEG C；
(3) solution I is slowly added into solution II in the state of keeping continuous stirring, nacreous mica is added after mixing
Powder 4g continues to stir that a kind of prevention and/or treatment onychomycosis can be obtained until being mixed thoroughly as colour generation reinforcing agent
Water-soluble nail product.
Embodiment 4
(1) effective component 4g (its Berberine 1g, SHIDAGONGLAO extract 3g), antibacterial anti-inflammatory functional component 1.8g are weighed
(wherein benzoic acid 0.8g, sodium acetate 0.5g, sodium salicylate 0.5g) is set with coalescing agent 12g (wherein glycerol 6g, ethylene glycol 6g)
In the beaker of 100ml, distilled water about 20ml is added, is heated to 55 DEG C under water bath condition and keeps the temperature, stirring is until be completely dissolved
Obtain solution I；
(2) claim film forming agent 1.2g (wherein agar 0.5g, pectin 0.5g, xanthan gum 0.2g) to be placed in the beaker of 200ml, add
The deionized water for entering 56ml is heated to 85 DEG C and keeps the temperature, continue stirring until and be completely dissolved, obtains solution II when being cooled to 50 DEG C；
(3) solution I is slowly added into solution II in the state of lasting stirring, nacreous mica gold is added after mixing
5g continues to stir the water that a kind of prevention and/or treatment onychomycosis can be obtained until being mixed thoroughly as colour generation reinforcing agent
Dissolubility nail-care products.
Embodiment 5
(1) jamaicin 1g is weighed as effective component, antibacterial anti-inflammatory functional component 4g (wherein sodium benzoate 1g, sodium acetate
1g, sodium salicylate 2g) and coalescing agent 10g (wherein glycerol 5g, ethylene glycol 5g) be placed in the beaker of 100ml, be added 20ml
Deionized water, be heated to 45 DEG C under water bath condition and keep the temperature, stirring is until be completely dissolved to obtain solution I；
(2) claim film forming agent 10g (wherein gelatin 5g, Arabic gum 5g) to be placed in the beaker of 200ml, 50ml is added in beaker
Deionized water, be heated to 75 DEG C and keep the temperature, continue stirring until the solid fully dissolved in beaker, obtain solution when being cooled to 50 DEG C
II；
(3) solution I is slowly added into solution II in the state of being kept stirring, nacreous mica gold is added after mixing
5g continues to stir the water that a kind of prevention and/or treatment onychomycosis can be obtained until being mixed thoroughly as colour generation reinforcing agent
Dissolubility nail-care products.
Embodiment 6
Product of the present invention in-vitro antibacterial effect experiment.
(1) 1 product of Example spends ion water making into 1.0,0.5,0.1mg/mL solution, sterilizes spare.
(2) 2 μ g/mL solution for standby are made with RPMI1640 fluid nutrient medium in Fluconazole.
(3) RPMI1640 Liquid Culture keynote will be used after Trichophyton rubrum (ATCC28191 purchases supreme marine growth net) activation
Section bacterial concentration is (2~6) × 105CFU/mL is spare.Face the used time, bacterium solution dilutes 50 times with RPMI1640 culture solution, final concentration
For (2~6) × 103CFU/mL。
(4) drawn respectively with pipettor in 100 μ L steps (1) concentration be 1.0,0.5,0.1mg/mL medical fluid is in 96 orifice plates
In corresponding aperture with final concentration of (2~6) × 10 in 100 μ L steps (3)3The bacterium solution of CFU/mL, which mixes, is used as test hole, Mei Genong
Degree 3 parallel groups of setting；Drawing concentration in 100 μ L steps (2) respectively with pipettor again is 2 μ g/mL medical fluids in the phase of 96 orifice plates
Final concentration of (2~6) × 10 in Ying Kongzhong and 100 μ L steps (3)3The bacterium solution of CFU/mL, which mixes, is used as test hole, each concentration
3 parallel groups are set；With final concentration of (2~6) × 10 in 100 μ L RPMI1640 culture solutions and 100 μ L steps (3)3CFU/mL
Bacterium solution be negative control, equally be arranged 3 parallel groups.96 orifice plates are placed at 30 DEG C constant temperature incubation 3-5 days, are observed daily,
When negative control hole (not inhibiting) is obvious muddy, absorbance value of each hole at 630nm is measured, according to the size of absorbance value
Judge fungistatic effect, the results are shown in Table 1.
The Fluconazole of product and 2 μ g/mL inhibit the effect of Trichophyton rubrum in 1 embodiment 1 of table
For upper table as it can be seen that in 2 μ g/mL, Fluconazole inhibits Trichophyton rubrum significant effect, illustrates that experimental method is reliable, real
It is feasible to test result.Product of the present invention has apparent inhibition to Trichophyton rubrum under each concentration of 1.0,0.5 and 0.1mg/mL
Effect illustrates that product of the invention has potential treatment and prevention effect to onychomycosis.
In-vitro antibacterial effect experiment is similarly used for using preparation-obtained product in embodiment 2-6, is in concentration
There is apparent inhibiting effect when 1.0mg/mL, 0.5mg/mL and 0.1mg/mL to Trichophyton rubrum.
In conclusion a kind of prevention and/or treatment onychomycosis that preparation method through the invention is prepared
The certain onychomycosis of water-soluble nail product has potential treatment and prevention effect, and has water solubility.
Finally, it is stated that preferred embodiment above is only used to illustrate the technical scheme of the present invention and not to limit it, although logical
It crosses above preferred embodiment the present invention is described in detail, however, those skilled in the art should understand that, can be
Various changes are made to it in form and in details, without departing from claims of the present invention limited range.
Claims (7)
1. the water-soluble nail product of a kind of prevention and/or treatment onychomycosis, which is characterized in that the nail-care products include effective
Ingredient, antibacterial anti-inflammatory functional component, coalescing agent, film forming agent, colour generation reinforcing agent and water, the effective component include barberry
Any one or more in alkali, coptis extract, phellodendron extract, Radix Berberidis extract or SHIDAGONGLAO extract.
2. the water-soluble nail product of a kind of prevention and/or treatment onychomycosis according to claim 1, which is characterized in that institute
The mass fraction for stating effective component described in nail-care products is 1~5%, and the mass fraction of the antibacterial anti-inflammatory functional component is
1.8~4%, the mass fraction of the coalescing agent is 10~12%, the mass fraction of the film forming agent is 1~15%, described
The mass fraction of colour generation reinforcing agent is 2~5%.
3. the water-soluble nail product of a kind of prevention and/or treatment onychomycosis according to claim 1, which is characterized in that institute
It states antibacterial anti-inflammatory functional component to be made of sodium benzoate, sodium salicylate and sodium acetate, the water is distilled water or deionized water.
4. the water-soluble nail product of a kind of prevention and/or treatment onychomycosis according to claim 2, which is characterized in that institute
Stating film forming agent is one of gelatin, seaweed glue, Arabic gum, pectin or xanthan gum or a variety of.
5. the water-soluble nail product of a kind of prevention and/or treatment onychomycosis according to claim 2, which is characterized in that institute
Stating coalescing agent is at least one of glycerol or ethylene glycol.
6. the water-soluble nail product of a kind of prevention and/or treatment onychomycosis according to claim 2, which is characterized in that institute
Stating colour generation reinforcing agent is at least one of nacreous mica powder or pearly-lustre gold.
7. a kind of any one of claim 1~6 preparation side for the water-soluble nail product for preventing and/or treating onychomycosis
Method, which is characterized in that the method concrete operations are as follows:
(1) by mass fraction be 1~5% effective component, mass fraction be 1.8~4% antibacterial anti-inflammatory functional component be placed in
In same container, coalescing agent and the water that mass fraction is 10~12% is added, heating maintains temperature under the conditions of 40~65 DEG C,
Stirring is to being completely dissolved, as solution I；
(2) film forming agent that mass fraction is 1~15% is placed in another container, is heated to 60~85 DEG C, stirred to completely molten
Xie Hou, taking-up are cooled to 40~55 DEG C as solution II；
(3) solution I in step (1) is slowly added in the solution II in step (2) by several times, it is stirring while adding, until mixing
Uniformly after be added 2~5% colour generation reinforcing agent, continue stirring until be uniformly mixed can be obtained it is a kind of prevention and/or treatment ash
The water-soluble nail product of nail.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109999074A (en) * | 2019-04-16 | 2019-07-12 | 信阳农林学院 | The preparation method and its usage of Chinese mahonia total alkaloid extract |
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| CN107823301A (en) * | 2017-10-18 | 2018-03-23 | 陈祥 | A kind of external medicinal liquid for treating onychomycosis and preparation method thereof |
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2019
- 2019-01-16 CN CN201910040340.XA patent/CN109528537A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107823301A (en) * | 2017-10-18 | 2018-03-23 | 陈祥 | A kind of external medicinal liquid for treating onychomycosis and preparation method thereof |
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| 中央农业广播电视学校: "《兽医基础》", 31 October 1991, 农业出版社 * |
| 佟盼琢等: "盐酸小檗碱对红色毛癣菌形态学的影响", 《中国皮肤性病学杂志》 * |
| 国家食品药品监督管理总局: "《化妆品安全技术规范》", 31 December 2016 * |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109999074A (en) * | 2019-04-16 | 2019-07-12 | 信阳农林学院 | The preparation method and its usage of Chinese mahonia total alkaloid extract |
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Application publication date: 20190329 |