CN105662956A - Preparation method of hand sanitizer for skin disinfection - Google Patents
Preparation method of hand sanitizer for skin disinfection Download PDFInfo
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
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- A61K8/678—Tocopherol, i.e. vitamin E
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- A61Q19/10—Washing or bathing preparations
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Abstract
The invention relates to a preparation method of a hand sanitizer for skin disinfection and belongs to the technical field of external preparations for skin. The method comprises steps as follows: water is added to a container, and fatty alcohol-polyoxyethylene ether (9), fatty alcohol-polyoxyethylene ether (7), coconut diethanolamide, dodecyl dimethyl betaine and polyoxyethylene fatty alcohol sodium sulfate are sequentially added while stirring to be fully and evenly stirred and dissolved; a camellia fruit extract, a folium eucalypti extract, a valerian root extract, a chamomile extract, trehalose and vitamin E are added and evenly stirred; 1,5-anhydro-D-fructose and an additive are added and evenly stirred, a pH regulator is added, and a finished product is obtained after filtration. The anti-bacterial hand sanitizer has the advantages of good stability and good bacterium killing and anti-bacterial effect.
Description
Technical field
The preparation method that the present invention relates to a kind of handwashing liquid for skin degerming, belongs to preparation for external application to skin technical field.
Background technology
According to the World Health Organization (WHO): diarrhoea and pneumonia are to cause the main arch-criminal of death of child at present, the whole world has 1,700,000 people to die from diarrhoea class disease every year, separately has 1,500,000 people to die from lower respiratory illness, and the overwhelming majority is developing country child. The child of half of which is because not forming the good habit washed one's hands with soap and causing death. Wash one's hands with soap diarrhoea fatality rate can be reduced by half, acute respiratory infection fatality rate reduces 1/3rd, say, that good custom of washing one's hands can save million child's life every year, all more useful than any vaccine or medical intervention. The World Health Organization (WHO) sets up " washing one's hands day in the world " in proposal in 2005, and purpose allows people pay much attention to this simple hygienic habit problem that washes one's hands with soap exactly.
CN102600053B discloses a kind of Chinese medicinal herb-inorganic antibacterial agent composite sterilization hand sanitizer, with Folium Artemisiae Argyi, Herba Artemisiae Annuae, Radix Scutellariae, Pericarpium Granati, Radix Glycyrrhizae extract for composite Chinese herbal antibacterial, with nano phase ag_2 o for inorganic antiseptic, make the strong bactericidal ability of nano phase ag_2 o combine with the long-acting bactericidal effect of Chinese herbal medicine, obtain that there is disinfecting handwashing liquid potent, long-acting bactericidal, bacteria resistance function. But including silver in this antimicrobial fluid, belong to heavy metal, life-time service can cause heavy metal gathering in vivo.
Open a kind of antimicrobial disinfection hand cleanser of CN100531706C and preparation method thereof, step: (1) takes sodium lauryl sulphate and adds in purified water, and heating, to 70-80 DEG C, is cooled to room temperature, obtains A liquid after dissolving; (2) povidone iodine is dissolved in A liquid, obtains B liquid; (3) take NPE to mix with dodecylbenzene sodium sulfonate and mix thoroughly, obtain C liquid; (4), after B liquid and C liquid being mixed, add glycerol and mix thoroughly, obtain antimicrobial disinfection hand cleanser. But containing iodine composition in this antimicrobial fluid, life-time service can cause skin color to deepen.
Summary of the invention
It is an object of the invention to: the handwashing liquid that a kind of good stability, bactericidal and bacteriostatic effect are good is provided.
Technical scheme is:
The preparation method of a kind of handwashing liquid for skin degerming, comprises the steps:
1st step, by weight, add 140~170 parts of water in a reservoir, be under agitation sequentially added into fatty alcohol-polyoxyethylene ether (9) 2~4 parts, fatty alcohol-polyoxyethylene ether (7) 3~5 parts, Cortex cocois radicis oleoyl diethanolamine 3~5 parts, dodecyldimethylammonium hydroxide inner salt 1~3 part, polyoxyethylenated alcohol sodium sulfate 2~4 parts stir dissolving;
2nd step, the mixture of the 1st step gained adds Flos Camelliae Japonicae berry extract 5~10 parts, Folium eucalypti globueli (Eucalyptus globulus Labill.) extract 2~4 parts, radix valerianae extract 2~4 parts, Flos Matricariae chamomillae extract 1~3 part, trehalose 2~4 parts, vitamin E 4~7 parts, and is stirred uniformly at 45~50 DEG C;
3rd step, adds 1,5-AF 1~3 part, additive 0.5~1 part in the mixture of the 2nd step gained, and after stirring at 25~30 DEG C, adds pH adjusting agent and make pH 5.5~6.5, obtain finished product after filtration.
In the 3rd described step, filtration is to adopt 200 order nylon screens to filter.
Described additive one or several mixture in antioxidant, preservative, essence.
Described antioxidant is selected from alpha-tocopherol, alpha-tocopherol cetylate, alpha-tocopherol acetate, tert-butyl hydroxy toluene, butylhydroxy anisole or one or several mixture in ascorbic acid.
Described preservative one or several mixture in benzoic acid, sorbic acid, sulfur dioxide, Potassium Benzoate, potassium sorbate, sodium benzoate, sodium sorbate, calcium benzoate or calcium sorbate.
Described essence one or several mixture in oleum menthae viridis, Oleum menthae, Fructus Citri Limoniae oil, Fructus Coriandri oil, orange-seed oil, mandarin oil, lime oil, Oleum lavandula angustifolia, laurel fat, chamomile oil, cardamom oil, caraway oil, bay tree leaf oil, lemongrass oil, pinke needle oil, orange blossom oil, attar of roses, Jasmin oil, flag flower extractum, Peppermint essential oil or Flos Rosae Multiflorae quintessence oil.
Beneficial effect
The advantage that anti-bacterial hand lotion provided by the invention has good stability, bactericidal and bacteriostatic effect is good.
Detailed description of the invention
Below by detailed description of the invention, the present invention is described in further detail. It will be apparent, however, to one skilled in the art, that the following example is merely to illustrate the present invention, and should not be taken as limiting the scope of the invention. Unreceipted concrete technology or condition person in embodiment, technology or condition described by the document in this area or carry out according to product description. Agents useful for same or the unreceipted production firm person of instrument, be can pass through city available from conventional products.
The numerical value as range limit not only including clearly listing should be interpreted as in a flexible way using the value of range format expression, but also include all single numerical value or the subinterval that are encompassed within the scope of this, it is expressly recited out just as each numerical value and subinterval. Such as, the concentration range of " about 0.1% to about 5% " should be understood to not only to include the concentration of about 0.1% to about 5% clearly listed, also include single concentration in institute's how (as, 1%, 2%, 3% and 4%) and subinterval (such as, 0.1% to 0.5%, 1% to 2.2%, 3.3% to 4.4%). Word used herein " includes ", " comprising ", " having " or its any other variant are intended to including of non-exclusionism. Such as, it is not necessarily limited by those key elements including listing the technique of key element, method, article or equipment, but can be included other and be not expressly set out or belong to the key element that this technique, method, article or equipment are intrinsic.
Active antibacterial ingredient effect in handwashing liquid in the present invention is as follows:
Containing tea saponin in Flos Camelliae Japonicae berry extract. Tea saponin has another name called TS, is a kind of soaping agents compound extracted from the seed of plant of theaceae. Also it is a kind of natural nonionic surfactant, it is possible to be used for manufacturing emulsifying agent, abluent, foaming agent etc. simultaneously.Tea saponin has many physiologically actives, such as hemolytic, antibacterial, antivirus action, anti-inflammatory, anti-allergic effects etc.
Folium eucalypti globueli (Eucalyptus globulus Labill.), for the leaf of myrtle Eucalyptus globulus Labill. Toil, cool. Merit can dispelling wind to relieve the exterior syndrome; Heat-clearing and toxic substances removing; Phlegm-eliminiating and qi-regulating; Killing parasites for relieving itching.
Radix valerianae is the root that can take from Valeriana officinalis var. latifolia (ValerianaofficinalisVar.LatifoliaMiq). Have concurrently wind dispelling, excitement, spasmolytic effect and there is tranquilizing by nourishing the heart, regulate the flow of vital energy, the effect such as promoting blood circulation and stopping pain.
Flos Matricariae chamomillae (matricariachamomillaL.) is natural perfume plant, it is possible to for as the aromatic activity material of handwashing liquid, and its extract also has certain calmness, cooling effect.
Trehalose is remarkably improved the stability of radix valerianae extract, and its trehalose can be effectively improved shelf-life, ageing stability and oxidation stability as adjuvant. Trehalose, is glucose and the disaccharide of fructose composition, the isomers of sucrose, obtains mainly through the isomerization of sucrose. But during for watery handwashing liquid, trehalose easily occurs reuniting along with the change of temperature the problem of crystallization, can cause that anti-Degradation is not high. And the mode passing through addition vitamin E can significantly change the agglomeration traits of trehalose, improve its action effect.
Above-mentioned Flos Camelliae Japonicae fruit, Folium eucalypti globueli (Eucalyptus globulus Labill.), radix valerianae and Flos Matricariae chamomillae extract can by the concentrate of acquisition after raw material stain is filtered, reduces pressure and is concentrated after solvent extraction. Above-mentioned solvent can be or multiple mixture in water, the anhydrous or aqueous alcohol of C1~C4, acetate fiber, glycerol, propylene glycol and propylene glycol, but is not limited to this. Extraction can be stood by room temperature and carry out, but can promote to extract as desired by heating, stir, being heated to reflux. The extracting solution of gained can directly use, or implements to use after suitably filtration, concentration, decolouring etc. process. It is further possible to after temporarily removing solvent, use after carrying out re-dissolved in the solvent different from extracting solvent used. Use after the extract of gained can also be further purified by activated carbon, column chromatography etc.
In another embodiment of the presently claimed invention, handwashing liquid also includes 1,5-D-anhydrofructose, generally it is applied in cure foods to suppress the breeding of the antibacterial generation to reduce nitrite, have herein been found that 1, the addition of 5-D-anhydrofructose can be effectively improved the decomposition avoiding Flos Camelliae Japonicae berry extract extract, to improve antibiotic property.
In addition to the above-mentioned components, according to actual application needs, it is also possible to comprising other additive component, described additive component can comprise other components of one or more applicable foods. These include antioxidant, emulsifying agent, preservative, sweeting agent, essence, pH adjusting agent etc.
Antioxidant can adopt tocopherols such as alpha-tocopherol, alpha-tocopherol cetylate, alpha-tocopherol acetate, tert-butyl hydroxy toluene, butylhydroxy anisole, ascorbic acid, its salt and ester, for instance sodium ascorbate, calcium ascorbate, Vitamin C acyl phosphate ester, the fatty acid ester such as Vitamin C acyl stearate of ascorbic acid and Vitamin C acyl cetylate and ethoxyquin.
As pH adjusting agent, can be included in the preparation compositions of the present invention to improve or to reduce the pH of the preparation compositions of the present invention. The pH of described preparation compositions can be lowered or improve, and for the effect that sense organ is perceived, or is used for improving physicochemical property, for instance increases the dissolubility of the compound dissolved. PH adjusting agent may refer to acidulant or basifier.The non-limiting example of acidulant is the edible acid of food stage, for instance, lactic acid, citric acid, malic acid, fumaric acid, adipic acid, phosphoric acid, gluconic acid, tartaric acid, ascorbic acid, acetic acid, succinic acid and maleic acid. The pH of preparation compositions can pass through to change the ratio of cation (such as, calcium cation, magnesium cation, sodium cation and potassium cationic) and acid constituents and regulate. The non-limiting example of basifier is the compound of such as sodium hydroxide, potassium hydroxide, calcium hydroxide and magnesium hydroxide etc.
Preservative, can be optionally included in the non-limiting example of the preservative in the preparation compositions of the present invention to include: acetic acid, citric acid, benzoic acid, sorbic acid, sulfur dioxide, Potassium Benzoate, potassium sorbate, sodium benzoate, sodium sorbate, calcium benzoate, calcium sorbate, sodium citrate, potassium citrate, sodium hexameta phosphate, nitrite, sulphite, etc. Preservative may also include the antioxidant of such as ascorbic acid, EDTA, BHA, BHT, TBHQ, Glacial acetic acid, two dimethyl carbonate, ethoxyquin and p-Hydroxybenzoate etc.
As essence, it is preferred to use oils and fats essence and powdered flavors such as one kind or two or more natural essence, compound essences, but it is not particularly limited. such as, natural essence can be enumerated: Olibanum oil, parsley oil, oleum anisi, eucalyptus oil, wintergreen oil, Oleum Cinnamomi, menthol oil, oleum menthae viridis, Oleum menthae, Fructus Citri Limoniae oil, Fructus Coriandri oil, orange-seed oil, mandarin oil, lime oil, Oleum lavandula angustifolia, laurel fat, chamomile oil, cardamom oil, caraway oil, bay tree leaf oil, lemongrass oil, pinke needle oil, orange blossom oil, attar of roses, Jasmin oil, flag flower extractum, Peppermint essential oil, Flos Rosae Multiflorae quintessence oil, Citrus flower, tangerine oil, mixing water fruit oil, Fructus Fragariae Ananssae oil, Ceylon cinnamon oil, Oleum Caryophylli, Fructus Vitis viniferae wet goods. as simple essence, can enumerate: carvone, anethole, methyl salicylate, cinnamic aldehyde, linalool, linalyl-acetate, limonene, menthone, menthyl acetate, sobrerone, octanal, citral, pulegone, carvacryl acetate, anisaldehyde, ethyl acetate, ethyl n-butyrate., hexamethylene allyl propionate, o-aminobenzoa, ethyl anthranilate, vanilione, undecalactone, hexanal, ethanol, propanol, butanol, isoamyl alcohol, hexenol, dimethyl sulfide, methyl cyclopentenyl ketone, bran aldehyde, trimethylpyrazine, ethyl lactate, ethyl thioacetate etc. as containing simple essence and/or the mixing essence containing natural essence, enumerating: Fructus Fragariae Ananssae perfume, Fructus Mali pumilae perfume, banana incense, Fructus Ananadis comosi perfume, Fructus Vitis viniferae perfume, Fructus Mangifera Indicae perfume, tropical fruit (tree) perfume, butter perfume, milk, Yoghourt perfume, fragrant, the mentha leave perfume of fruit mixing etc. it addition, the form of essence has quintessence oil, extract, solids, can also be the powder obtained by they spray drying.
The preparation of embodiment 1 extract
The composition of Flos Camelliae Japonicae fruit, Folium eucalypti globueli (Eucalyptus globulus Labill.), radix valerianae and Flos Matricariae chamomillae is extracted by the mode that can adopt following ethanol extraction.
Respectively the Flos Camelliae Japonicae fruit of pulverizing, Folium eucalypti globueli (Eucalyptus globulus Labill.), radix valerianae and Flos Matricariae chamomillae 100g be impregnated in 50% ethanol (v/v) 500g, under 60 DEG C of temperature conditions, carry out circulation extraction of heating 3 hours, filter and decompression, concentrate drying, obtain 9g, 8g9g and 11g extract powder respectively.
Embodiment 2
For the preparation method of the handwashing liquid of skin degerming, comprise the steps:
1st step, by weight, add 150 parts of water in a reservoir, be under agitation sequentially added into fatty alcohol-polyoxyethylene ether (9) 3 parts, fatty alcohol-polyoxyethylene ether (7) 4 parts, Cortex cocois radicis oleoyl diethanolamine 4 parts, dodecyldimethylammonium hydroxide inner salt 2 parts, polyoxyethylenated alcohol sodium sulfate 3 parts stir dissolving;
2nd step, adds Flos Camelliae Japonicae berry extract 6 parts, Folium eucalypti globueli (Eucalyptus globulus Labill.) extract 3 parts, radix valerianae extract 3 parts, Flos Matricariae chamomillae extract 2 parts, trehalose 3 parts, vitamin E 5 parts in the mixture of the 1st step gained, and is stirred uniformly at 47 DEG C;
3rd step, the mixture of the 2nd step gained adds 1,5-D-anhydrofructose 2 parts, antioxidant alpha-tocopherol 0.3 part, preservative sorbic acid 0.3 part, essence Oleum lavandula angustifolia 0.3 part, and after stirring at 27 DEG C, adding pH adjusting agent makes pH 6.0, adopts 200 order nylon screens to obtain finished product after filtering.
Reference examples 1
It is distinctive in that with embodiment 2: the 2nd step does not add trehalose.
1st step, by weight, add 150 parts of water in a reservoir, be under agitation sequentially added into fatty alcohol-polyoxyethylene ether (9) 3 parts, fatty alcohol-polyoxyethylene ether (7) 4 parts, Cortex cocois radicis oleoyl diethanolamine 4 parts, dodecyldimethylammonium hydroxide inner salt 2 parts, polyoxyethylenated alcohol sodium sulfate 3 parts stir dissolving;
2nd step, adds Flos Camelliae Japonicae berry extract 6 parts, Folium eucalypti globueli (Eucalyptus globulus Labill.) extract 3 parts, radix valerianae extract 3 parts, Flos Matricariae chamomillae extract 2 parts, vitamin E 5 parts in the mixture of the 1st step gained, and is stirred uniformly at 47 DEG C;
3rd step, the mixture of the 2nd step gained adds 1,5-D-anhydrofructose 2 parts, antioxidant alpha-tocopherol 0.3 part, preservative sorbic acid 0.3 part, essence Oleum lavandula angustifolia 0.3 part, and after stirring at 27 DEG C, adding pH adjusting agent makes pH 6.0, adopts 200 order nylon screens to obtain finished product after filtering.
Reference examples 2
It is distinctive in that with embodiment 2: the 2nd step does not add radix valerianae extract.
1st step, by weight, add 150 parts of water in a reservoir, be under agitation sequentially added into fatty alcohol-polyoxyethylene ether (9) 3 parts, fatty alcohol-polyoxyethylene ether (7) 4 parts, Cortex cocois radicis oleoyl diethanolamine 4 parts, dodecyldimethylammonium hydroxide inner salt 2 parts, polyoxyethylenated alcohol sodium sulfate 3 parts stir dissolving;
2nd step, adds Flos Camelliae Japonicae berry extract 6 parts, Folium eucalypti globueli (Eucalyptus globulus Labill.) extract 3 parts, Flos Matricariae chamomillae extract 2 parts, trehalose 3 parts, vitamin E 5 parts in the mixture of the 1st step gained, and is stirred uniformly at 47 DEG C;
3rd step, the mixture of the 2nd step gained adds 1,5-D-anhydrofructose 2 parts, antioxidant alpha-tocopherol 0.3 part, preservative sorbic acid 0.3 part, essence Oleum lavandula angustifolia 0.3 part, and after stirring at 27 DEG C, adding pH adjusting agent makes pH 6.0, adopts 200 order nylon screens to obtain finished product after filtering.
Reference examples 3
It is distinctive in that with embodiment 2: the 2nd step does not add trehalose and radix valerianae extract.
1st step, by weight, add 150 parts of water in a reservoir, be under agitation sequentially added into fatty alcohol-polyoxyethylene ether (9) 3 parts, fatty alcohol-polyoxyethylene ether (7) 4 parts, Cortex cocois radicis oleoyl diethanolamine 4 parts, dodecyldimethylammonium hydroxide inner salt 2 parts, polyoxyethylenated alcohol sodium sulfate 3 parts stir dissolving;
2nd step, adds Flos Camelliae Japonicae berry extract 6 parts, Folium eucalypti globueli (Eucalyptus globulus Labill.) extract 3 parts, Flos Matricariae chamomillae extract 2 parts, vitamin E 5 parts in the mixture of the 1st step gained, and is stirred uniformly at 47 DEG C;
3rd step, the mixture of the 2nd step gained adds 1,5-D-anhydrofructose 2 parts, antioxidant alpha-tocopherol 0.3 part, preservative sorbic acid 0.3 part, essence Oleum lavandula angustifolia 0.3 part, and after stirring at 27 DEG C, adding pH adjusting agent makes pH 6.0, adopts 200 order nylon screens to obtain finished product after filtering.
Reference examples 4
It is distinctive in that with embodiment 2: the 3rd step does not add 1,5-D-anhydrofructose.
1st step, by weight, add 150 parts of water in a reservoir, be under agitation sequentially added into fatty alcohol-polyoxyethylene ether (9) 3 parts, fatty alcohol-polyoxyethylene ether (7) 4 parts, Cortex cocois radicis oleoyl diethanolamine 4 parts, dodecyldimethylammonium hydroxide inner salt 2 parts, polyoxyethylenated alcohol sodium sulfate 3 parts stir dissolving;
2nd step, adds Flos Camelliae Japonicae berry extract 6 parts, Folium eucalypti globueli (Eucalyptus globulus Labill.) extract 3 parts, radix valerianae extract 3 parts, Flos Matricariae chamomillae extract 2 parts, trehalose 3 parts, vitamin E 5 parts in the mixture of the 1st step gained, and is stirred uniformly at 47 DEG C;
3rd step, the mixture of the 2nd step gained adds antioxidant alpha-tocopherol 0.3 part, preservative sorbic acid 0.3 part, essence Oleum lavandula angustifolia 0.3 part, and after stirring at 27 DEG C, add pH adjusting agent and make pH 6.0, adopt 200 order nylon screens to obtain finished product after filtering.
Performance test
Randomly choose in institute medical personnel 250 example, be randomly divided into 5 groups, often organize 50 people, use the anti-bacterial lotion product in embodiment 2 and reference examples 1-4 respectively. Using method: conventional common soap is washed one's hands and is rinsed with tap water, uses this product q.s in both hands, uniformly rubs in hand, especially between finger tip and finger, keeps the time of contact of 30 seconds, natural drying; Further take out it addition, this product in use, is required for storage at normal temperatures and test after 7 days.
Method of testing according to Disease Control and Prevention Center (CDC), in People's Republic of China's hand disinfection technical specification 2002 that infection control tissue is proposed. At 37 DEG C of temperature, test biology is angstrom Xi Shi escherichia coli, staphylococcus aureus, a bacillus pyocyaneus, and the biological content of each test is 107/ ml, time of contact is 1 minute. Requirement by detecting: the minimum microorganism (killing rate > 99.9%) killing 3 logarithms. Every results averaged.
Result of the test is:
Product Quick disinfection test result: qualified.
Table 1 is to killing bacteria logarithm value
Embodiment 2 | Reference examples 1 | Reference examples 2 | Reference examples 3 | Reference examples 4 | |
Angstrom Xi Shi escherichia coli | 8 | 6 | 6 | 6 | 7 |
Staphylococcus aureus | 8 | 7 | 7 | 6 | 7 |
Bacillus pyocyaneus | 8 | 6 | 6 | 6 | 7 |
As can be seen from the above table, handwashing liquid provided by the invention has good antibiotic property.
Product long-acting bacteriostatic test result: the hand natural bacteria average kill ratio after using 3 minutes, after 3 hours, after 4 hours is shown in following table:
Table 2 hand natural bacteria average kill ratio (%)
Embodiment 2 | Reference examples 1 | Reference examples 2 | Reference examples 3 | Reference examples 4 | |
3min | 100% | 99% | 99% | 98% | 98% |
3h | 99.3% | 92.3% | 92.4% | 91.6% | 92.2% |
4h | 98.6% | 88.2% | 87.3% | 86.1% | 83.2% |
As can be seen from the table, anti-bacterial lotion provided by the invention, after 4h, still has good bacterial inactivation rate; In reference examples 4, owing to not adding 1,5-AF, result in the decomposition of Flos Camelliae Japonicae berry extract extract, after skin effect, fungistatic effect is more not high.
In process of the test, part sample is had to there occurs the situation of hand skin redness, pruritus, this situation analysis is as follows:
A situation arises in table 3 untoward reaction
As can be seen from the table, owing to not adding trehalose in reference examples 1, allow for radix valerianae extract and there is the problem of decomposition, result in the decreased effectiveness of its Lavender Extract; In reference examples 2, owing to not adding radix valerianae extract, so it does not have the effect of good anti-red swelling of the skin yet; Reference examples 3 is not added with trehalose and radix valerianae extract simultaneously, is as blank, it can be seen that trehalose and radix valerianae extract can produce synergism.
Claims (6)
1. the preparation method for the handwashing liquid of skin degerming, it is characterized in that, comprise the steps: the 1st step, by weight, add 140~170 parts of water in a reservoir, be under agitation sequentially added into fatty alcohol-polyoxyethylene ether (9) 2~4 parts, fatty alcohol-polyoxyethylene ether (7) 3~5 parts, Cortex cocois radicis oleoyl diethanolamine 3~5 parts, dodecyldimethylammonium hydroxide inner salt 1~3 part, polyoxyethylenated alcohol sodium sulfate 2~4 parts stir dissolving;2nd step, the mixture of the 1st step gained adds Flos Camelliae Japonicae berry extract 5~10 parts, Folium eucalypti globueli (Eucalyptus globulus Labill.) extract 2~4 parts, radix valerianae extract 2~4 parts, Flos Matricariae chamomillae extract 1~3 part, trehalose 2~4 parts, vitamin E 4~7 parts, and is stirred uniformly at 45~50 DEG C; 3rd step, adds 1,5-AF 1~3 part, additive 0.5~1 part in the mixture of the 2nd step gained, and after stirring at 25~30 DEG C, adds pH adjusting agent and make pH 5.5~6.5, obtain finished product after filtration.
2. the preparation method of the handwashing liquid for skin degerming according to claim 1, it is characterised in that: in the 3rd described step, filtration is to adopt 200 order nylon screens to filter.
3. the preparation method of the handwashing liquid for skin degerming according to claim 1, it is characterised in that: described additive one or several mixture in antioxidant, preservative, essence.
4. the preparation method of the handwashing liquid for skin degerming according to claim 1, it is characterized in that: described antioxidant is selected from alpha-tocopherol, alpha-tocopherol cetylate, alpha-tocopherol acetate, tert-butyl hydroxy toluene, butylhydroxy anisole or one or several mixture in ascorbic acid.
5. the preparation method of the handwashing liquid for skin degerming according to claim 1, it is characterised in that: described preservative one or several mixture in benzoic acid, sorbic acid, sulfur dioxide, Potassium Benzoate, potassium sorbate, sodium benzoate, sodium sorbate, calcium benzoate or calcium sorbate.
6. the preparation method of the handwashing liquid for skin degerming according to claim 1, it is characterised in that: described essence one or several mixture in oleum menthae viridis, Oleum menthae, Fructus Citri Limoniae oil, Fructus Coriandri oil, orange-seed oil, mandarin oil, lime oil, Oleum lavandula angustifolia, laurel fat, chamomile oil, cardamom oil, caraway oil, bay tree leaf oil, lemongrass oil, pinke needle oil, orange blossom oil, attar of roses, Jasmin oil, flag flower extractum, Peppermint essential oil or Flos Rosae Multiflorae quintessence oil.
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CN106983682A (en) * | 2017-03-19 | 2017-07-28 | 长沙协浩吉生物工程有限公司 | A kind of compound method of ferment hand cleanser |
CN106983675A (en) * | 2017-03-19 | 2017-07-28 | 长沙协浩吉生物工程有限公司 | A kind of compound method of ferment hand cleanser |
CN106994112A (en) * | 2017-03-19 | 2017-08-01 | 长沙协浩吉生物工程有限公司 | A kind of compound method of ferment hand cleanser |
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Cited By (4)
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CN106983682A (en) * | 2017-03-19 | 2017-07-28 | 长沙协浩吉生物工程有限公司 | A kind of compound method of ferment hand cleanser |
CN106983675A (en) * | 2017-03-19 | 2017-07-28 | 长沙协浩吉生物工程有限公司 | A kind of compound method of ferment hand cleanser |
CN106994112A (en) * | 2017-03-19 | 2017-08-01 | 长沙协浩吉生物工程有限公司 | A kind of compound method of ferment hand cleanser |
CN107115254A (en) * | 2017-06-04 | 2017-09-01 | 张东 | A kind of sleep mask acted on moisturizing and pore cleanser and preparation method thereof |
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