CN105709173A - Curcuma oil emulsion and preparation process thereof - Google Patents
Curcuma oil emulsion and preparation process thereof Download PDFInfo
- Publication number
- CN105709173A CN105709173A CN201610099639.9A CN201610099639A CN105709173A CN 105709173 A CN105709173 A CN 105709173A CN 201610099639 A CN201610099639 A CN 201610099639A CN 105709173 A CN105709173 A CN 105709173A
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- turmeric oil
- solution
- oil emulsion
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- colloid mill
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
Abstract
The invention belongs to traditional Chinese medicine emulsion and particularly relates to curcuma oil emulsion and a preparation process thereof. The curcuma oil emulsion is prepared from, by volume, 1-5% of curcuma oil, 1-2% of emulsifier, 2-4% of auxiliary emulsifier, 0.5-2% of preservative, 0.025-0.05% of anti-oxidant and 88-95% of water. By means of the curcuma oil emulsion and the preparation process thereof, the defects that curcuma oil is volatile, unstable, great in pungency and inconvenient to use are overcome, and a new preparation for animal use which is more stable, more efficient, environmentally friendly, safe, free of medicine resistance, free of residues and convenient to use is provided for the market.
Description
Technical field
The invention belongs to Chinese medicine emulsion, be specifically related to a kind of turmeric oil Emulsion and preparation technology thereof.
Background technology
Turmeric oil is the extract of natural plants Rhizoma Curcumae Longae, it it is a kind of natural antibiotics, turmeric oil has antibacterial and sterilizing function, turmeric oil is in production application, it is primarily used to promote growth of animal and preventing and treating animal intestinal disease, turmeric oil has broad spectrum activity and high efficiency, experiment shows, turmeric oil has certain inhibitory action to the common bacteria causing enteritis, such as escherichia coli, Salmonella, dysentery bacterium etc., turmeric oil applied range, it is used not only in laying hen, broiler, on the poultry such as duck, can be additionally used in pig, on the animals such as cattle Aquatic product, turmeric oil safety, environmental protection, noresidue, pathogenic microorganism will not be made to produce drug resistance, meet currently extensively advocate efficient, green, the requirement of environmental protection, it it is current comparatively ideal Substitutes For Antibiotic.
The main meat Egg Quality usually improving poultry with Rhizoma Curcumae Longae and raising rate of growth in the market, the application of turmeric oil is relatively fewer, in turmeric oil, main chemical compositions is curcumene, heerabolene, limonene, sesquiphellandrene, aryl turmerone, turmerone, curcumenol curdione etc..Modern pharmacology research shows, turmeric oil has antioxidation well, antibacterial, antiviral, antitumor etc. act on, the turmeric oil that vapor distillation extracts is to Candida albicans, Cryptococcus histolyticus trichophyton, trichophyton gypseums etc. all have suppression in various degree, MIC is 1.25-0.078%, the turmeric oil of Petroleum ether extraction, several frequently seen putrefaction bacteria and pathogenic bacterium had obvious inhibitory action, wherein the strongest to staphylococcus aureus inhibition, MIC=1.25%, antibacterial circle diameter is 17.5mm, it is MIC=5% to colibacillary inhibitory action, antibacterial circle diameter is 10mm.Turmeric oil is with its good action effect and the feature being not likely to produce drug resistance, by favorable comment widely.
Turmeric oil pre-mixing agent has been obtained for checking during poultry use; increase along with large-scale cultivation; a large amount of uses of complete feed; drinking-water becomes main route of administration, and premix material in use causes inconvenience, and we are on this basis; by research Recipe; it is made for turmeric oil emulsion oral formulations, using effect can be strengthened by drinking-water effectively prevention and treatment livestock and poultry intestinal canal diseases.Turmeric oil is prepared as Emulsion, volatile oil is coated in water, volatility can be reduced.Turmeric oil Emulsion can also be uniformly distributed in drinking-water well, brings convenience for poultry medication.
Summary of the invention
The main object of the present invention is to solve the shortcoming that turmeric oil is volatile, unstable, application is inconvenient, a kind of stability and high efficiency is provided for market, green safety, have no drug resistance noresidue, animal-use drug novel form easy to use, for achieving the above object, the present invention is through Multitest, work out a kind of novel formulation, turmeric oil Emulsion.
The present invention is achieved by the following technical solutions: 1, a kind of turmeric oil Emulsion, it is to be prepared from by the component of volumes below percentage ratio: turmeric oil, 0.5-10%；Emulsifying agent 0.5-20%；Co-emulsifier 0.5-10%；Preservative 0.01-1%；Antioxidant 0.005-0.1%；Water 60-98%.
Preferably, a kind of turmeric oil Emulsion, it is to be prepared from by the component of volumes below percentage ratio: turmeric oil 1-5%, emulsifying agent 1-2%, co-emulsifier 2-4%, preservative 0.5-2%, antioxidant 0.025-0.05%, water 88-95%.
Described emulsifying agent is Tweens or spans.
Described co-emulsifier is one or more in ethanol, propylene glycol, glycerol.
Described preservative is one or more in phenol, sodium benzoate, methyl hydroxybenzoate, propylparaben, chlorobutanol or ethyl hydroxybenzoate.
Described antioxidant is butylated hydroxyarisol or di-tert-butyl hydroxy toluene.
Described medicinal plant oil is soybean oil, Oleum Brassicae campestris.
Further preferably, a kind of turmeric oil Emulsion, is prepared from by the component of volumes below percentage ratio: turmeric oil 1-3%, sorbester p17 are 0.4-1%, tween 80 is 0.5-5%, ethanol 0.4-1%, propylene glycol are 1-5%, benzyl alcohol 0.5-1%, butylated hydroxyarisol 0.01-0.05%, di-tert-butyl hydroxy toluene 0.01-0.05%, water 81.9-96.18%.
Optimal case, a kind of turmeric oil Emulsion, it is to be prepared from by the component of volumes below percentage ratio: turmeric oil 2%, and sorbester p17 is 0.5%, and tween 80 is 1%, ethanol 0.5%, propylene glycol is 2.6%, benzyl alcohol 0.9%, butylated hydroxyarisol 0.025%, di-tert-butyl hydroxy toluene 0.025%, the constant volume that adds water is to 100%.
2, present invention also offers the preparation technology of above-mentioned turmeric oil Emulsion, it is to be prepared by following steps:
Method one: preservative is dissolved in appropriate smuggled goods low carbon fat alcohol, it is emulsifying agent, co-emulsifier is dissolved in the water together becomes solution A, solution A is added in colloid mill, regulation rotating speed, stirring mixing 5-10 minute, oil-soluble antioxidant is dissolved in ethanol, it is then added in turmeric oil become solution B, the A liquid that B is slowly added in colloid mill, emulsifying 10-60 minute, then filter, obtain turmeric oil Emulsion, turmeric oil method of preparing emulsion, can also be first solution B to be added colloid mill, then solution A is added in solution B, emulsifying is carried out in colloid mill.
Method two: oil-soluble inhibitor is dissolved in ethanol, join in turmeric oil, again with emulsifying agent, co-emulsifier mixes, the solution C stirred, solution C is added in colloid mill, adjust rotating speed, stirring and evenly mixing 5-10 minute, preservative is dissolved in suitable quantity of water or low carbon fat alcohol, add Sufficient purified water and obtain solution D, D liquid is added the C liquid in colloid mill, emulsifying 10-60 minute, then filter, obtain turmeric oil Emulsion, the preparation method of turmeric oil Emulsion, can also be first solution D to be added colloid mill, then solution C is added in solution D in colloid mill, carry out emulsifying.
A kind of turmeric oil Emulsion that the present invention provides, has the advantages that
(1) formula of the present invention obtains through screening, selecting and the determination of mutual proportionate relationship of co-emulsifier, and the emulsion obtained is not layered and the phenomenon such as breakdown of emulsion, the application of antioxidant preservative, and Emulsion can be made to have the longer shelf-life；
(2) in preparation technology, using the process that colloid mill stirring is pulverized, be that the emulsion droplet of turmeric oil Emulsion is less, evenly, heat stability is more preferable in dispersion；
(3) present invention efficiently solves the volatile instability of turmeric oil, zest is big, in-convenience in use deficiency, to market provide a kind of more stable efficiently, green safety, the animal-use drug novel formulation that the noresidue that has no drug resistance is easy to use.
Detailed description of the invention
Below in conjunction with example, the detailed description of the invention of the present invention is described in detail.
Embodiment 1
1, a kind of turmeric oil Emulsion, it is to be prepared from by the component of volumes below percentage ratio: turmeric oil 20%, and sorbester p17 is 5ml, tween 80 is 10ml, ethanol 5ml, and propylene glycol is 26ml, benzyl alcohol 9ml, butylated hydroxyarisol 0.25ml, di-tert-butyl hydroxy toluene 0.25ml；Add water constant volume to 1000ml.
2, the preparation technology of a kind of turmeric oil Emulsion, it is to be prepared by following steps: be dissolved in purified water by benzyl alcohol, adds sorbester p17, Tween 80 and propylene glycol, stirring and dissolving, becomes solution A, solution A is added in colloid mill, regulation rotating speed is 2000 revs/min, stirring mixing 5 minutes；Oil-soluble inhibitor BHA and BHT is dissolved in ethanol, adds in turmeric oil and become solution B, the A liquid that solution B is slowly added in colloid mill, emulsifying 30 minutes, then filter, subpackage, obtain 2% turmeric oil Emulsion.
Embodiment 2
1, a kind of turmeric oil Emulsion, it is to be prepared from by the component of volumes below percentage ratio: turmeric oil 50ml, and sorbester p17 is 20ml, tween 80 is 50ml, ethanol 10ml, and propylene glycol is 45ml, benzyl alcohol 9ml, butylated hydroxyarisol 0.45ml, di-tert-butyl hydroxy toluene 0.45ml；Add water constant volume to 1000ml.
2, the preparation technology of a kind of turmeric oil Emulsion, it is to be prepared by following steps: be dissolved in purified water by benzyl alcohol, adds sorbester p17, Tween 80 and propylene glycol, stirring and dissolving, becomes solution A, solution A is added in colloid mill, regulation rotating speed is 2000 revs/min, stirring mixing 5 minutes；Oil-soluble inhibitor BHA and BHT is dissolved in ethanol, adds in turmeric oil and become solution B, the A liquid that solution B is slowly added in colloid mill, emulsifying 30 minutes, then filter, subpackage, obtain 2% turmeric oil Emulsion.
Embodiment 3
By tests below, the drug effect of the present invention is described further
Tested medicine: 2% turmeric oil Emulsion of embodiment 1
Control drug: the turmeric oil solution of 2%, (with edible oil, turmeric oil is diluted to the solution of 2%)
Test method: extracting waste rabbit two, two pieces of unhairing that area is 4*4cm are chosen in animal trunk both sides, apply tested medicine 4 in unhairing region, be applied to surface equably with Glass rod, after applying 4 hours, left drug is washed away with suds, examining 12 hours, 24 hours, 48 hours, the reaction of 72 hours after coating, the change of itemized record coating part skin, as reactionless in first time coating 24 hours, still can every day coating once, till local response occurs.
Result of the test: 2% turmeric oil Emulsion is reactionless in first time coating 24 hours, for the second time after coating, observed at 12 hours and slight congested phenomenon occurs, disappearing hyperemia in 24 hours, recover normal, 2% turmeric oil solution is after first time coating is cleaned for 4 hours with suds, the most congested phenomenon is had with regard to visible coating position, observing at 12 hours and find still there is hyperemia, within 24 hours, still have slight hyperemia, 48 the most no longer have hyperemia.
Conclusion: the turmeric oil Emulsion of 2% has slight local irritation, and 2% turmeric oil solution has stronger local irritation, this is because the turmeric oil in turmeric oil Emulsion is coated by emulsion droplet, it is impossible to direct skin contact, therefore its zest is greatly reduced.
Above-described embodiment; including the composition of turmeric oil Emulsion, preparation technology, stability test etc.; to the present invention have been described in detail; these describe be illustrative rather than determinate, can according to restriction scope list several embodiments, once changing and modifications under without departing from present general inventive concept; protection scope of the present invention should be belonged to; in range of application, include the tinea manuum, tinea pedis simultaneously, the application of tinea corporis falls within the range of the present invention.
Claims (9)
1. a turmeric oil Emulsion, it is characterised in that it is to be prepared from by the component of volumes below percentage ratio: turmeric oil, 0.5-10%；Emulsifying agent 0.5-20%；Co-emulsifier 0.5-10%；Preservative 0.01-1%；Antioxidant 0.005-0.1%；Water 60-98%.
2. turmeric oil Emulsion as claimed in claim 1, it is characterised in that it is to be prepared from by the component of volumes below percentage ratio: turmeric oil 1-5%, emulsifying agent 1-2%, co-emulsifier 2-4%, preservative 0.5-2%, antioxidant 0.025-0.05%, water 88-95%.
3. the emulsifying agent as described in claim 1-2, it is characterised in that described emulsifying agent is Tweens or spans.
4. the co-emulsifier as described in claim 1-2, it is characterised in that described co-emulsifier is one or more in ethanol, propylene glycol, glycerol.
5. the preservative as described in claim 1-2, it is characterised in that described preservative is one or more in phenol, sodium benzoate, methyl hydroxybenzoate, propylparaben, chlorobutanol or ethyl hydroxybenzoate.
6. the antioxidant as described in claim 1-2, it is characterised in that described antioxidant is butylated hydroxyarisol or di-tert-butyl hydroxy toluene.
7. turmeric oil Emulsion as claimed in claim 1, it is characterized in that, described turmeric oil Emulsion is prepared from by the component of volumes below percentage ratio: turmeric oil 1-3%, sorbester p17 are 0.4-1%, tween 80 is 0.5-5%, ethanol 0.4-1%, propylene glycol are 1-5%, benzyl alcohol 0.5-1%, butylated hydroxyarisol 0.01-0.05%, di-tert-butyl hydroxy toluene 0.01-0.05%, water 81.9-96.18%.
8. turmeric oil emulsifying agent as claimed in claim 1, it is characterized in that, described turmeric oil Emulsion is prepared from by the component of volumes below percentage ratio: turmeric oil 2%, and sorbester p17 is 0.5%, and tween 80 is 1%, ethanol 0.5%, propylene glycol is 2.6%, benzyl alcohol 0.9%, butylated hydroxyarisol 0.025%, di-tert-butyl hydroxy toluene 0.025%, the constant volume that adds water is to 100%.
9. turmeric oil Emulsion as claimed in claim 1, it is characterised in that the preparation technology of described turmeric oil Emulsion is as follows:
Method one: preservative is dissolved in appropriate smuggled goods low carbon fat alcohol, it is emulsifying agent, co-emulsifier is dissolved in the water together becomes solution A, solution A is added in colloid mill, regulation rotating speed, stirring mixing 5-10 minute, oil-soluble antioxidant is dissolved in ethanol, it is then added in turmeric oil become solution B, the A liquid that B is slowly added in colloid mill, emulsifying 10-60 minute, then filter, obtain turmeric oil Emulsion, turmeric oil method of preparing emulsion, can also be first solution B to be added colloid mill, then solution A is added in solution B, emulsifying is carried out in colloid mill；
Method two: oil-soluble inhibitor is dissolved in ethanol, join in turmeric oil, again with emulsifying agent, co-emulsifier mixes, the solution C stirred, solution C is added in colloid mill, adjust rotating speed, stirring and evenly mixing 5-10 minute, preservative is dissolved in suitable quantity of water or low carbon fat alcohol, add Sufficient purified water and obtain solution D, D liquid is added the C liquid in colloid mill, emulsifying 10-60 minute, then filter, obtain turmeric oil Emulsion, the preparation method of turmeric oil Emulsion, can also be now solution D to be added colloid mill, then solution C is added in solution D in colloid mill, carry out emulsifying.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610099639.9A CN105709173A (en) | 2016-02-24 | 2016-02-24 | Curcuma oil emulsion and preparation process thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610099639.9A CN105709173A (en) | 2016-02-24 | 2016-02-24 | Curcuma oil emulsion and preparation process thereof |
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| CN105709173A true CN105709173A (en) | 2016-06-29 |
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| CN201610099639.9A Pending CN105709173A (en) | 2016-02-24 | 2016-02-24 | Curcuma oil emulsion and preparation process thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108013234A (en) * | 2016-11-04 | 2018-05-11 | 李侯根 | Feed turmeric composite antioxidant and preparation method thereof |
| CN110711190A (en) * | 2019-09-20 | 2020-01-21 | 广西科学院 | Terpenoid inhibitor for resisting fish diseases and preparation method and application thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102920781A (en) * | 2012-11-02 | 2013-02-13 | 青岛康地恩药业股份有限公司 | Natural oregano oil emulsion and preparation process thereof |
-
2016
- 2016-02-24 CN CN201610099639.9A patent/CN105709173A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102920781A (en) * | 2012-11-02 | 2013-02-13 | 青岛康地恩药业股份有限公司 | Natural oregano oil emulsion and preparation process thereof |
Non-Patent Citations (1)
| Title |
|---|
| 戴伦凯: "《中国药用植物志（第十二卷）》", 31 January 2013 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108013234A (en) * | 2016-11-04 | 2018-05-11 | 李侯根 | Feed turmeric composite antioxidant and preparation method thereof |
| CN110711190A (en) * | 2019-09-20 | 2020-01-21 | 广西科学院 | Terpenoid inhibitor for resisting fish diseases and preparation method and application thereof |
| CN110711190B (en) * | 2019-09-20 | 2023-08-25 | 广西科学院 | Terpenoid inhibitor for resisting fish diseases and preparation method and application thereof |
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Application publication date: 20160629 |
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