CN105639120A - Cyclodextrin inclusion compound containing antibiotic components, a compounding method thereof and feed additive - Google Patents
Cyclodextrin inclusion compound containing antibiotic components, a compounding method thereof and feed additive Download PDFInfo
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- CN105639120A CN105639120A CN201511019668.1A CN201511019668A CN105639120A CN 105639120 A CN105639120 A CN 105639120A CN 201511019668 A CN201511019668 A CN 201511019668A CN 105639120 A CN105639120 A CN 105639120A
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- cyclodextrin
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
Abstract
The invention provides a cyclodextrin inclusion compound containing antibacterial components and a compounding method of the cyclodextrin inclusion compound. The cyclodextrin inclusion compound containing the antibacterial components is prepared from an inclusion agent and the antibacterial components, wherein the inclusion agent is cyclodextrin and/or a derivative of the cyclodextrin; a weight ratio of the inclusion agent and a component antibacterial agent is (0.5 to 500) : 1. The compounding method of the cyclodextrin inclusion compound comprises the following steps of mixing and stirring the inclusion agent, the component antibacterial agent and a solvent; completing inclusion; distilling to remove the solvent, thus obtaining the cyclodextrin inclusion compound. The cyclodextrin inclusion compound provided by the invention is used in the aspects of feed, a feed additive and the like and is used for replacing the functions of health protection, growth promotion, oxidation resistance and the like of existing feed antibiotic antibacterial drugs; according to the cyclodextrin inclusion compound provided by the invention, the problems of poor palatability, strong pungency, poor water solubility, easiness in volatilization, easiness in oxidation, instability, strong smell and the like caused by the existence of a single antibacterial component are solved, and a new path is developed for wide application of the component antibacterial agent; the controlled release effect is good.
Description
Technical field
The present invention relates to field of fodder, in particular to the cyclodextrin clathrate of antimicrobial component and synthetic method thereof and feed additive.
Background technology
Within 1986, Switzerland forbids feeding antibiotic, and within 2006, European Union forbids feeding antibiotic, and within 2014, U.S. FDA issues directive document, plans progressively to forbid feeding antibiotic in 3 years afterwards, and " rear antibiotic epoch " arrive.
China's feed industry has been sent out flourish in 30 years since the eighties, define 1.97 hundred million tons of world-class annual productions, the dog-eat-dog competition epoch now into big merger, greatly integration, extremely low profit, each big business create profit " cutting ferrum on needle point " invariably, save or grow the enterprise of oneself. Seem " the rear antibiotic epoch " necessarily arrived are not appeared to how many preparations. Now, a kind of antibiotic substitute is developed extremely urgent.
Before this, more existing antibiotic substitute occurs, with allylic thioether compound, the naturally occurring or synthetic quintessence oil such as 3-phenyl-2-acrylic aldehyde, the different base phenol of 5-methyl-2-, methyl salicylate, lauryl alcohol sulfoacetic acid ester is main. Although these quintessence oils are cheap, but there is respective shortcoming, such as palatability is not good, zest is strong, poorly water-soluble, volatile, oxidizable, unstable, tanginess disturb residents, and there is a big difference with vision to cause practical effect, it is impossible to promotes the use of.
In view of this, the special proposition present invention.
Summary of the invention
The first object of the present invention is in that to provide the cyclodextrin clathrate of a kind of antimicrobial component, described cyclodextrin clathrate not only solves the problems such as palatability not good, zest strong, poorly water-soluble, volatile, oxidizable, unstable, the tanginess of single antimicrobial component existence, and the extensive use for antimicrobial component opens new way; And controlled-release effect is good.
The second object of the present invention is in that to provide the synthetic method of the cyclodextrin clathrate of a kind of described antimicrobial component, and described synthetic method inclusion rate is high, and flow process is simple.
The second object of the present invention is in that to provide a kind of feed additive, and this feed additive has effects such as improving the immunity of animal, anti-bacteria and anti-virus, antioxidation, food calling, growth promotion, substitute antibiotics, improve food conversion ratio.
In order to realize the above-mentioned purpose of the present invention, spy by the following technical solutions:
A kind of antimicrobial component, mainly formed by inclusion agents inclusion antimicrobial component, described inclusion agents is the derivant of cyclodextrin and/or cyclodextrin; The weight ratio of described inclusion agents and antimicrobial component is 0.5-500:1.
Above-mentioned clathrate is with cyclodextrin and derivant thereof for inclusion agents, by antimicrobial component inclusion interior, cyclodextrin and derivant thereof mainly by cyclodextrin and derivant thereof and human contact, and are also exposed to by the cyclodextrin clathrate finally given in administration process in depositing process. Firstly, since cyclodextrin and derivant thereof can solubilising, not volatile, not oxidizable, Heat stability is good, mouthfeel and abnormal smells from the patient are gentle, therefore, high by the product of its inclusion not only water solubility, and not volatile, not oxidizable, Heat stability is good, mouthfeel and abnormal smells from the patient all gentlenesses do not stimulate. Secondly, by reaching the effect of slow release after antimicrobial component inclusion, experiment proves that, product has good controlled-release effect really. 3rd, cost of material used in above-mentioned clathrate is all low, for instance the synthesis of cyclodextrin and derivant thereof and extractive technique are quite ripe, it is easy to buying, and antimicrobial component can extract from plant, less costly equally.
Through test, the above-mentioned clathrate of the present invention is in inclusion rate loss rate after the open storage of room temperature in 30 days below 3.2%, and the dissolubility of 25 DEG C is more than 25%, and after drying 10 minutes in 90 DEG C of baking ovens, loss rate is below 15.4%. It addition, above clathrate has multiple use, for instance for feedstuff, feed additive, veterinary drug, there is effects such as improving the immunity of animal, anti-bacteria and anti-virus, antioxidation, food calling, growth promotion, substitute antibiotics, improve food conversion ratio.
Above-mentioned clathrate can optimize further:
Preferably, described antimicrobial component is selected from sulfide compound, 3-phenyl-2-acrylic aldehyde, salicylide, anisaldehyde, citral, methyl salicylate, pi-allyl mequinol, neo-houttuyninum, decanoylacetaldehyde sulfurous hydracid sodium, Carvacrol, 5-isopropyl phenol, (trans) 8-methyl-N-vanillin-6-nonenamide, curcumin, Quercetin, baicalin, to-1-alcohol-1 in the Meng, 8-cineole, (5S)-5-oxybenzene-1-(4-hydroxy 3-methoxybenzene base)-3-ketone in the last of the ten Heavenly stems, Paeonolum, estragole, berberine hydrochloride, one or more in 1.8-dihydroxy-3-tectoquinone.
Above medicine is inclusion all easily, and the selectivity of solvent is low. It addition, these compositions can be natural extract, it is also possible to be synthetics.
Preferably, described cyclodextrin is selected from one or more in ��-ring paste, beta-schardinger dextrin-, gamma-cyclodextrin and their derivant, it is preferred to beta-schardinger dextrin-. The cost of these several cyclodextrin is low, and source is wide, and especially the cost of beta-schardinger dextrin-is minimum.
The derivant of described cyclodextrin is selected from one or more in hydroxy-beta-cyclodextrin hydroxyethyl-��-cyclodextrin, dihydroxypropyl-beta-schardinger dextrin-, glucose ring dextrin, maltose cyclodextrin or maltotriose cyclodextrin.
Comparatively speaking, the derivative molecular amount of these cyclodextrin is relatively big, and molecule cavity is bigger, and inclusion rate is high.
Preferably, described inclusion agents is 1.8-12:1 with the weight ratio of antimicrobial component.
After this ratio inclusion, stability is better.
Preferably, described inclusion agents is 7.5-9:1 with the weight ratio of antimicrobial component.
After this ratio inclusion, controlled-release effect is better.
The synthetic method of the cyclodextrin clathrate of antimicrobial component mentioned above, comprises the following steps:
By inclusion agents, antimicrobial component and solvent mix and blend, complete inclusion, described solvent is distilled off afterwards, obtains product.
Above-mentioned clathrate is with solvent medium, completes inclusion mainly through mix and blend, this operation reduces the heat loss of inclusion agents and oxidational losses, and then improves inclusion rate. Wherein, solvent mainly type according to antimicrobial component selects, and typically, solvent is more high to the dissolubility of inclusion agents and antimicrobial component, and the interracial contact of inclusion agents and antimicrobial component is in hgher efficiency, and inclusion speed and inclusion rate are also just higher.
Above-mentioned synthetic method can also optimize further:
Preferably, the method for described mix and blend is:
First described antimicrobial component is dissolved with described solvent, obtain antimicrobial; Then described antimicrobial being joined in inclusion agents, being stirred for until completing inclusion.
Such addition sequence can ensure that, antimicrobial component is in the state of " inclusion agents accounting is higher " all the time with inclusion agents when merging, to improve inclusion rate.
Preferably, described stirring is to stir 10-30 minute at 30-165 DEG C.
Heat up and be conducive to improving the mobility of compound, improve inclusion speed.
Preferably, when described antimicrobial component is Oleum Bulbus Allii, described solvent is dichloromethane; When described antimicrobial component is one or more in curcumin, berberine, (trans) 8-methyl-N-vanillin-6-nonenamide, described solvent is ethanol.
As mentioned previously, according to different antibacterial types, select solvent targetedly, be conducive to improving inclusion rate. In addition, when described antimicrobial component is one or more in water electrode acid methyl ester, allyl methoxyl phenol, lauric acid sulfoacetic acid ester, decanoylacetaldehyde, Carvacrol, 5-methyl-2-isopropyl-phenol, anethole, described solvent is boiling range is the petroleum ether of 90-120 DEG C; Described antimicrobial component is neo-houttuyninum; During decanoylacetaldehyde sodium hydrosulfite, described solvent is water.
A kind of feed additive, including the cyclodextrin clathrate of diluent Yu antimicrobial component mentioned above, the proportioning of both is content is 100:0.001��80.0.
As described above, this feedstuff is owing to the addition of the cyclodextrin clathrate of antimicrobial component, and optimize adding proportion, therefore there is effects such as improving the immunity of animal, anti-bacteria and anti-virus, antioxidation, food calling, growth promotion, substitute antibiotics, improve food conversion ratio. It addition, diluent can be normal feedstuff or the edible material of other animal.
This feedstuff this can optimize further, mainly optimize adding proportion, for instance, add the cyclodextrin clathrate of the antimicrobial component of 0.001��10%.
Compared with prior art, the invention have the benefit that
(1) a kind of new antimicrobial component is developed: it can not only substitute antibiotics, and it is not not volatile, oxidizable, Heat stability is good, mouthfeel and abnormal smells from the patient all gentlenesses do not stimulate, good palatability, dissolubility is high, a kind of excellent performance, very low cost feed additive, it will have wide market prospect.
(2) preparation method is simple, and inclusion rate is high.
(3) for different medicines, it is provided that preferred solvent.
Detailed description of the invention
Below in conjunction with embodiment, embodiment of the present invention are described in detail, it will be appreciated by those skilled in the art that the following example is merely to illustrate the present invention, and are not construed as restriction the scope of the present invention. Unreceipted actual conditions person in embodiment, conventionally the condition of condition or manufacturer's suggestion carries out. Agents useful for same or the unreceipted production firm person of instrument, be and can pass through the commercially available conventional products bought and obtain.
Embodiment one:
100kg allyl compound (Oleum Bulbus Allii) and 500kg dichloromethane are stirred, pumps into the 2M of 900kg beta-schardinger dextrin-3In rake type drier, stir 30 minutes at 40 �� 5 DEG C, distillate dichloromethane and the Oleum Bulbus Allii of non-inclusion, cooling recycling use, after dichloromethane all reclaims, release reactant cooling, obtain product Oleum Bulbus Allii Benexate Hydrochloride, Oleum Bulbus Allii abnormal smells from the patient is very light, and relatively the Oleum Bulbus Allii abnormal smells from the patient of common adsorbents absorption substantially reduces.
Embodiment two:
80kg3-phenyl-2-acrylic aldehyde is uniform with the petroleum ether and stirring of 500kg boiling range 60��90 DEG C, pump into the 2M of 900kg beta-schardinger dextrin-3In rake type drier, stir 30 minutes at 70 �� 5 DEG C, distillate the 3-phenyl-2-acrylic aldehyde of petroleum ether and non-inclusion, cooling recycling use, after petroleum ether all reclaims, releases reactant cooling, obtain product 3-phenyl-2-acrylic aldehyde Benexate Hydrochloride, cinnamic odor is very light, and relatively the cinnamic aldehyde abnormal smells from the patient of common adsorbents absorption substantially reduces, and recording cinnamic aldehyde content is 7.95%.
Embodiment three:
The petroleum ether of 120kg methyl salicylate with boiling range 90-120 DEG C is mixed homogeneously, pumps into the 2M of 900kg beta-schardinger dextrin-3In rake type drier, stir 30 minutes at 120 �� 5 DEG C, distillate petroleum ether and the methyl salicylate of non-inclusion, cooling recycling use, after petroleum ether all reclaims, releases reactant cooling, obtaining product methyl salicylate Benexate Hydrochloride, recording wintergreen oil content is 11.96%.
Embodiment four:
The allyl methoxyl phenol 120kg petroleum ether with boiling range 90-120 DEG C is mixed homogeneously, pumps into the 2M of 900kg beta-schardinger dextrin-3In rake type drier, stir 30 minutes at 120 �� 5 DEG C, distillate the allyl methoxyl phenol of petroleum ether and non-inclusion, cooling recycling use, after petroleum ether all reclaims, releasing reactant cools down, and obtains product allyl methoxyl phenol Benexate Hydrochloride, and recording eugenol content is 11.95%.
Embodiment five:
120kg neo-houttuyninum is uniform with 300kg deionized water and stirring, pump into the 2M of 900kg beta-schardinger dextrin-3In rake type drier, stirring 30 minutes at 100 �� 5 DEG C, distillate moisture, release reactant cooling, obtain product neo-houttuyninum Benexate Hydrochloride, recording neo-houttuyninum sodium content is 11.90%.
Embodiment six:
By 120kg decanoylacetaldehyde sodium hydrosulfite and water 300KG, pump into the 2M of 900kg3In rake type drier, stirring 30 minutes at 100 �� 5 DEG C, distillate hydrone, release reactant cooling, obtain product decanoylacetaldehyde sodium hydrosulfite Benexate Hydrochloride, recording decanoylacetaldehyde sodium hydrosulfite content is 11.92%.
Embodiment seven:
By the petroleum ether of 110kg2-methyl-5-isopropyl-phenol Yu 100kg boiling range 90-120 DEG C, pump into the 2M of 900kg beta-schardinger dextrin-3In rake type drier, stir 30 minutes at 115 �� 5 DEG C, distillate petroleum ether and the Carvacrol of non-inclusion, cooling recycling use, after petroleum ether all reclaims, releasing reactant cools down, and obtains product Carvacrol Benexate Hydrochloride, and recording carvacrol content is 10.95%.
Embodiment eight:
By 120kg5-methyl-2-isopropyl-phenol, pump into the 2M of 900kg beta-schardinger dextrin-3In rake type drier, stir 30 minutes at 115 �� 5 DEG C, distillate the 5-methyl-2-isopropyl-phenol of petroleum ether and non-inclusion, cooling recycling use, after petroleum ether all reclaims, releasing reactant cools down, and obtains product 5-methyl-2-isopropyl-phenol Benexate Hydrochloride, and recording thymol content is 11.99%.
Embodiment nine:
(trans) 8-methyl-N-vanillin-6-nonenamide 80kg and 400kg ethanol are pumped into the 2M of 900kg beta-schardinger dextrin-3In rake type drier, stir 30 minutes at 90 �� 5 DEG C, distillate (trans) 8-methyl-N-vanillin-6-nonenamide of petroleum ether and non-inclusion, cooling recycling use, after petroleum ether all reclaims, releasing reactant cools down, and obtains product (trans) 8-methyl-N-vanillin-6-nonenamide Benexate Hydrochloride, and recording capsaicin content is 7.95%.
Embodiment ten:
Will to the Meng-1-alcohol-1.8-cineole 100kg with boiling range 60-90 DEG C of petroleum ether, pump into the 2M of 900kg beta-schardinger dextrin-3In rake type drier, stir 30 minutes at 90 �� 5 DEG C, distillate petroleum ether and non-inclusion to-1-alcohol-1.8-cineole in the Meng, cooling recycling use, after petroleum ether all reclaims, releasing reactant cools down, and obtains product to-1-alcohol-1.8-cineole Benexate Hydrochloride in the Meng, and recording-1-alcohol-4-1.8 cineole content in the Meng is 9.79%.
Embodiment 11
By berberine hydrochloride (berberine) 100kg, fully dissolve with 600kg ethanol and make clear solution, enter to have the 2M of 900kg beta-schardinger dextrin-3In rake type drier, stir 30 minutes at 80 �� 5 DEG C, distillate ethanol, cooling recycling use, after ethanol all reclaims, releases reactant cooling, obtaining product berberine hydrochloride (berberine) Benexate Hydrochloride, recording berberine content is 9.73%, and bitterness substantially reduces.
Embodiment 12
Anethole's (anethole) 100kg dissolves in the petroleum ether of 600kg90-120 DEG C of boiling range, makes clear solution, make clear solution, pump into the 2M of 900kg beta-schardinger dextrin-3In rake type drier, stir 30 minutes at 90 �� 5 DEG C, distillate the acrylic methoxybenzene (anethole) of petroleum ether and non-inclusion, cooling recycling use, after all reclaiming, releasing reactant cools down, and obtains product acrylic methoxybenzene (anethole) Benexate Hydrochloride, and recording content is 9.69%.
Embodiment 13
Curcumin 100kg is fully dissolved in 600kg dehydrated alcohol, pumps into the 2M of 900kg beta-schardinger dextrin-3In rake type drier, stirring 30 minutes at 80 �� 5 DEG C, distillate ethanol, cool down recycling use, after ethanol all reclaims, release reactant cooling, obtain product curcumin Benexate Hydrochloride, recording curcumin content is 9.89%.
Embodiment 14
Quercetin 100kg is fully dissolved in 600kg acetic acid, pumps into the 2M of 900kg beta-schardinger dextrin-3In rake type drier, stirring 30 minutes at 130 �� 5 DEG C, distillate acetic acid, cool down recycling use, after acetic acid all reclaims, release reactant cooling, obtain product Quercetin Benexate Hydrochloride, recording quercetin content is 9.93%.
Embodiment 15
By baicalin 100kg, it is substantially soluble in 500kgN, in dinethylformamide, pumps into the 2M of 900kg beta-schardinger dextrin-3In rake type drier, stir 30 minutes at 160 �� 5 DEG C, distillate DMF, cooling recycling use, after all reclaiming in DMF, releasing reactant cools down, and obtains product baicalin Benexate Hydrochloride, and recording content of baicalin is 9.69%.
These cyclodextrin can be used in the same way: alpha-cyclodextrin, gamma-cyclodextrin and their derivant, hydroxy-beta-cyclodextrin, hydroxyethyl-��-cyclodextrin, dihydroxypropyl-beta-schardinger dextrin-, glucose ring dextrin, maltose cyclodextrin or maltotriose cyclodextrin, the following plants antimicrobial composition of inclusion: allylic thioether compound, 3-phenyl-2-acrylic aldehyde, salicylide, anisaldehyde, citral, methyl salicylate, pi-allyl mequinol, neo-houttuyninum, decanoylacetaldehyde sodium hydrosulfite, Carvacrol, 5-isopropyl phenol, (trans) 8-methyl-N-vanillin-6-nonenamide, curcumin, Quercetin, baicalin, to-1-alcohol-1 in the Meng, 8-cineole, (5S)-5-oxybenzene-1-(4-hydroxy 3-methoxybenzene base)-3-ketone in the last of the ten Heavenly stems, Paeonolum, estragole, berberine hydrochloride, 1.8-dihydroxy-3-tectoquinone.
The physicochemical property of detection embodiment one to ten five gained plant antimicrobial Benexate Hydrochloride, find: clathrate in inclusion rate loss rate after the open storage of room temperature in 30 days below 3.2%, the dissolubility of 25 DEG C is more than 25%, and after drying 10 minutes in 90 DEG C of baking ovens, loss rate is below 15.4%. It addition, apply in feedstuff by above plant antimicrobial Benexate Hydrochloride, the appetite of piglet can be improved; And compared with the white carbon adsorbate of identical antimicrobial component, drug effect, mouthfeel, abnormal smells from the patient color and luster, excitement all make moderate progress. First being listed below shown in table 1 by the index of embodiment one, two, seven, comparison 1,2,3 is respectively as follows: the common adsorbate of white carbon of the common adsorbate of white carbon of Oleum Bulbus Allii, the common adsorbate of white carbon of cinnamic aldehyde, 2-methyl-5-different base phenol.
Wherein, the method for testing of each project is as follows.
Stability: the active ingredient inclusion rate after the open storage of determinand room temperature 7 days, 15 days, 30 days;
Water solublity: (25 DEG C) 100 grams of water dissolution grams;
Palatability: respectively take active ingredient 100 grams, adds and respectively feeds 20 pigs in 30 age in days piglet diets, count the average daily feed intake (gram) of pig;
Zest: respectively take and newly join active ingredient 10 grams, is configured to 100 grams of emulsions with emulsifying agent and is respectively applied to the skin of dorsum of hand of 5 people, meter red swelling of the skin pain time;
Volatility: each product 100 grams that newly does dries the loss rate % measuring active ingredient for 10 minutes in 90 DEG C of baking ovens;
Abnormal smells from the patient color and luster: room temperature is observed after placing 30 days;
Non-oxidizability: take 30 days products of storage, respectively takes 100 grams by drug effect and adds 100kg, measures the Oleum Glycines storage natural law at 60 DEG C of environment mesometamorphisms in same Oleum Glycines;
Drug effect: minimum inhibitory concentration (by the initial active ingredient) mg/L to Salmonella of the product after storing 30 days;
Mouthfeel: the storage at normal temperature product every kind of 30 days allows 5 people taste with the tip of the tongue simultaneously;
Controlled-release effect: respectively take fresh product by active ingredient 100 grams, strong stirring 1 hour in 37 DEG C of 5000mL warm water, stand, collect water surface grease (gram).
The physical and chemical index of table 1 medicine
Although illustrate and describing the present invention with specific embodiment, however it will be appreciated that may be made that when without departing substantially from the spirit and scope of the present invention many other change and amendment. It is, therefore, intended that include all such changes and modifications belonging in the scope of the invention in the following claims.
Claims (10)
1. the cyclodextrin clathrate of an antimicrobial component, it is characterised in that being mainly made up of inclusion agents inclusion antimicrobial component, described inclusion agents is the derivant of cyclodextrin and/or cyclodextrin;The weight ratio of described inclusion agents and antimicrobial component is 0.5-500:1.
2. the cyclodextrin clathrate of antimicrobial component according to claim 1, it is characterized in that, described antimicrobial component is selected from allylic thioether compound, 3-phenyl-2-acrylic aldehyde, salicylide, anisaldehyde, citral, methyl salicylate, pi-allyl mequinol, neo-houttuyninum, decanoylacetaldehyde sodium hydrosulfite, Carvacrol, 5-isopropyl phenol, (trans) 8-methyl-N-vanillin-6-nonenamide, curcumin, Quercetin, baicalin, to-1-alcohol-1 in the Meng, 8-cineole, (5S)-5-oxybenzene-1-(4-hydroxy 3-methoxybenzene base)-3-ketone in the last of the ten Heavenly stems, Paeonolum, estragole, berberine hydrochloride, one or more in 1.8-dihydroxy-3-tectoquinone.
3. the cyclodextrin clathrate of antimicrobial component according to claim 1, it is characterised in that described cyclodextrin is selected from one or more in alpha-cyclodextrin, beta-schardinger dextrin-, gamma-cyclodextrin and their derivant, it is preferred to beta-schardinger dextrin-.
The derivant of described cyclodextrin is selected from one or more in hydroxy-beta-cyclodextrin, hydroxyethyl-��-cyclodextrin, dihydroxypropyl-beta-schardinger dextrin-, glucose ring dextrin, maltose cyclodextrin or maltotriose cyclodextrin.
4. the cyclodextrin clathrate of antimicrobial component according to claim 1, it is characterised in that the weight ratio of described inclusion agents and antimicrobial component is 1.8-12:1, it is preferable that 7.5��9:1.
5. a feed additive, it is characterised in that including the cyclodextrin clathrate of diluent and the antimicrobial component described in any one of claim 1-4, the proportioning of both is content is 100:0.001��99000.0.
6. feed additive according to claim 5, it is characterised in that antimicrobial component clathrate addition in feedstuff is 0.001��10000mg/kg.
7. the synthetic method of the cyclodextrin clathrate of the antimicrobial component described in any one of claim 1-4, it is characterised in that comprise the following steps:
By inclusion agents, antimicrobial component and solvent mix and blend, complete inclusion, described solvent is distilled off afterwards, obtains product.
8. the synthetic method of the cyclodextrin clathrate of antimicrobial component according to claim 7, it is characterised in that the method for described mix and blend is:
First described antimicrobial component is dissolved with described solvent, obtain antimicrobial; Then described antimicrobial being joined in inclusion agents, being stirred for until completing inclusion.
9. the synthetic method of the cyclodextrin clathrate of antimicrobial component according to claim 8, it is characterised in that described stirring is to stir 10-30 minute at 30-165 DEG C.
10. the synthetic method of the cyclodextrin clathrate of antimicrobial component according to claim 7, it is characterised in that when described antimicrobial component is Oleum Bulbus Allii, described solvent is dichloromethane, acetone, ether; When described antimicrobial component is one or more in curcumin, berberine, (trans) 8-methyl-N-vanillin-6-nonenamide, described solvent is ethanol, methanol;
When described antimicrobial component is one or more in methyl salicylate, allyl methoxyl phenol, Carvacrol, 5-methyl-2-isopropyl-phenol, anethole, described solvent is boiling range is the petroleum ether of 90-120 DEG C; When described antimicrobial component is baicalin, described solvent is DMF, dimethyl sulfoxide;When described antimicrobial component is Quercetin, described solvent is acetic acid, formic acid, propanoic acid, butanoic acid; Described bacterium composition is 3-phenyl-2-acrylic aldehyde, to-1-in Meng alcohol-1, during 8 cineole, described solvent is boiling range is the petroleum ether of 60-90 DEG C; When described antimicrobial component is neo-houttuyninum, decanoylacetaldehyde sodium hydrosulfite, described solvent is water.
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