CN108379127A - Acne removal essential oil composition and its preparation method and application - Google Patents
Acne removal essential oil composition and its preparation method and application Download PDFInfo
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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- A61K8/678—Tocopherol, i.e. vitamin E
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Abstract
The present invention provides a kind of acne removal essential oil compositions and its preparation method and application,It is related to medical cosmetic technical field,Acne removal essential oil composition includes 15 parts of Forsythia suspense essential oil according to the mass fraction,0.1 1 parts of schizonepeta essential oil,0.1 1 parts of frutus cnidii essential oil,0.1 1 parts of grass-leaved sweetflag essential oil,0.05 0.5 parts of Peppermint essential oil,0.1 1 parts of Lavender,0.5 2 parts of chamomile essential oil,20 30 parts of Sweet Almond Oil,10 20 parts of vitamin E,10 25 parts of 20 30 parts of wheat-germ oil and SIMMONDSIA CHINENSIS SEED OIL,It is big and of high cost to improve existing Western medicine anti-acne poisonous side effect of medicine,The effect of folk prescription essential oil is single,The inapparent technical problem of curative effect,Acne removal essential oil composition provided by the invention can not only adjust sebum secretion balance,Anti-inflammatory sterilization,Self maintenance of active cell,And acne print can be desalinated,It releives skin,It is safe and efficient simultaneously,It has no toxic side effect,Rapid recovery patient suffering.
Description
Technical field
The present invention relates to medical cosmetic technical fields, more particularly, to a kind of acne removal essential oil composition and preparation method thereof
And application.
Background technology
Acne is commonly called as whelk, is a kind of chronic inflammation skin disease of hair follicle and sebaceous glands, be common disease, frequently-occurring disease, especially
It easily betides puberty men and women.Showing as face has acne, papule or a useless fellow, and face, head and back generate blackhead, in vain
Head acne and dense born of the same parents.The generation of acne is mainly blocked with hypersteatosis, pilosebaceous duct, bacterium infection and inflammation are anti-
Factors should be waited closely related.Adolesce androgen especially testosterone in descendant's body level it is rapid increase, promote sebaceous glands
It develops and generates a large amount of sebums.The dyskeratosis of pilosebaceous duct causes catheter blockage, dyssebacia to be formed simultaneously
Horn plug, that is, micro mist thorn.Multiple-microorganism especially propionibacterium acnes mass propagation in hair follicle, what propionibacterium acnes generated
Lipase decomposes sebum and generates free fatty, while chemotactic inflammatory cell and medium, finally induces and aggravates inflammatory reaction.
Currently, having tretinoin, benzoyl peroxide, antibiotics, azelaic acid, sulphur for anti-acne local topical drug
The toxic side effect of the Western medicine such as lotion, Western medicine is big and of high cost；Most of acne removal essential oil on the market is that folk prescription essential oil adds base oil
Allotment is made, and effect is single, and curative effect is not notable.
In view of this, special propose the present invention.
Invention content
One of the objects of the present invention is to provide a kind of acne removal essential oil compositions, to improve existing anti-acne drug as Western medicine
Or folk prescription essential oil, Western medicine toxic side effect is big and of high cost, and folk prescription essential oil acts on single, the inapparent technical problem of curative effect.
Acne removal essential oil composition provided by the invention, including following component according to the mass fraction：1-5 parts of Forsythia suspense essential oil,
0.1-1 parts of schizonepeta essential oil, 0.1-1 parts of frutus cnidii essential oil, 0.1-1 parts of grass-leaved sweetflag essential oil, 0.05-0.5 parts of Peppermint essential oil, lavender
0.1-1 parts of essential oil, 0.5-2 parts of chamomile essential oil, 20-30 parts of Sweet Almond Oil, 10-20 parts of vitamin E, wheat-germ oil 20-30
Part, 10-25 parts of SIMMONDSIA CHINENSIS SEED OIL, the sum of above-mentioned each component is 100 parts.
Further, the acne removal essential oil composition includes following component according to the mass fraction：2-4 parts of Forsythia suspense essential oil,
0.4-1 parts of schizonepeta essential oil, 0.2-0.7 parts of frutus cnidii essential oil, 0.2-0.8 parts of grass-leaved sweetflag essential oil, 0.05-0.45 parts of Peppermint essential oil,
0.15-0.8 parts of Lavender, 1-2 parts of chamomile essential oil, 20-30 parts of Sweet Almond Oil, 10-20 parts of vitamin E, wheat embryo
20-30 parts oily, 10-25 parts of SIMMONDSIA CHINENSIS SEED OIL, the sum of above-mentioned each component is 100 parts.
Further, the acne removal essential oil composition includes following component according to the mass fraction：3-4 parts of Forsythia suspense essential oil,
0.5-0.8 parts of schizonepeta essential oil, 0.4-0.6 parts of frutus cnidii essential oil, 0.3-0.7 parts of grass-leaved sweetflag essential oil, 0.2-0.4 parts of Peppermint essential oil,
0.3-0.7 parts of Lavender, 1-2 parts of chamomile essential oil, 20-30 parts of Sweet Almond Oil, 10-20 parts of vitamin E, wheat embryo
20-30 parts oily, 10-25 parts of SIMMONDSIA CHINENSIS SEED OIL, the sum of above-mentioned each combination is 100 parts.
Further, the acne removal essential oil composition further includes 0.2-1 parts of auxiliary agent according to the mass fraction；
Preferably, the auxiliary agent includes gelling agent, moisturizer or at least one of the preservatives.
Further, the gelling agent is selected from methylcellulose, hydroxypropyl methyl cellulose, hydroxypropyl cellulose, poly- second
At least one of glycol or polyvinyl alcohol.
Further, the moisturizer is selected from diethylene glycol, dipropylene glycol, ethylene glycol, hexylene glycol, isoprene, fourth two
At least one of alcohol or pentanediol.
Further, the preservative is Phenoxyethanol and/or Sensiva SC50.
The second object of the present invention is to provide the preparation method of above-mentioned acne removal essential oil composition, include the following steps：
By Forsythia suspense essential oil, schizonepeta essential oil, frutus cnidii essential oil, grass-leaved sweetflag essential oil, Peppermint essential oil, Lavender, chamomile
Essential oil, Sweet Almond Oil, vitamin E, wheat-germ oil, SIMMONDSIA CHINENSIS SEED OIL and optional auxiliary agent are uniformly mixed, and obtain acne removal essential oil
Composition.
Further, first Sweet Almond Oil, vitamin E, wheat-germ oil, SIMMONDSIA CHINENSIS SEED OIL are uniformly mixed, are sequentially added
Forsythia suspense essential oil, chamomile essential oil, Jing Jie essential oils, grass-leaved sweetflag essential oil, Lavender, frutus cnidii essential oil, Peppermint essential oil and optionally
Auxiliary agent be uniformly mixed.
The third object of the present invention is to provide application of the acne removal essential oil composition in skin care item.
Acne removal essential oil composition provided by the invention is on the basis that traditional Chinese medicine compatibility theory and essential oil blending technology are combined
Under, pass through Forsythia suspense essential oil, Jing Jie essential oils, frutus cnidii essential oil, grass-leaved sweetflag essential oil, Peppermint essential oil, Lavender, chamomile essence
It is flat can not only to adjust sebum secretion for oil, Sweet Almond Oil, vitamin E, wheat-germ oil and the mutual coordinated of SIMMONDSIA CHINENSIS SEED OIL
Weighing apparatus, anti-inflammatory sterilization, active cell self maintenance, and can desalinate acne print, skin of releiving, while safe and efficient are nontoxic secondary to make
With patient suffering can be effectively relieved.
The preparation method of acne removal essential oil composition provided by the invention is simple for process, easy to operate, and it is big to be suitable for industrialization
Production, can effectively improve production efficiency.
Specific implementation mode
Embodiment of the present invention is described in detail below in conjunction with embodiment, but those skilled in the art will
Understand, the following example is merely to illustrate the present invention, and is not construed as limiting the scope of the invention.It is not specified in embodiment specific
Condition person carries out according to conventional conditions or manufacturer's recommended conditions.Reagents or instruments used without specified manufacturer is
The conventional products that can be obtained by commercially available purchase.
According to an aspect of the present invention, the present invention provides a kind of acne removal essential oil compositions, including according to the mass fraction
Following component：1-5 parts of Forsythia suspense essential oil, 0.1-1 parts of schizonepeta essential oil, 0.1-1 parts of frutus cnidii essential oil, 0.1-1 parts of grass-leaved sweetflag essential oil,
0.05-0.5 parts of Peppermint essential oil, 0.1-1 parts of Lavender, 0.5-2 parts of chamomile essential oil, 20-30 parts of Sweet Almond Oil, vitamin
10-20 parts of E, 20-30 parts of wheat-germ oil, 10-20 parts of SIMMONDSIA CHINENSIS SEED OIL, the sum of above-mentioned each component are 100 parts.
In the present invention, the typical but non-limiting mass fraction of Forsythia suspense essential oil as 1,1.2,1.5,1.8,2,2.2,
2.5,2.8,3,3.2,3.5,3.8,4,4.2,4.5,4.8 or 5 parts.Forsythia suspense essential oil has clearing heat and detoxicating, blood cooling and ecchymoses removing and antioxygen
The effect of change.
The typical but non-limiting mass fraction of schizonepeta essential oil as 0.1,0.15,0.2,0.25,0.3,0.35,0.4,
0.45,0.5,0.55,0.6,0.65,0.7,0.75,0.8,0.85,0.9,0.95 or 1 part.Schizonepeta essential oil have antipyretic-antalgic and
The effect of anti-inflammatory.
The typical but non-limiting mass fraction of frutus cnidii essential oil as 0.1,0.15,0.2,0.25,0.3,0.35,
0.4,0.45,0.5,0.55,0.6,0.65,0.7,0.75,0.8,0.85,0.9,0.95 or 1 part.Frutus cnidii essential oil has eliminating dampness
With antipruritic effectiveness.
The typical but non-limiting mass fraction of grass-leaved sweetflag essential oil as 0.1,0.15,0.2,0.25,0.3,0.35,
0.4,0.45,0.5,0.55,0.6,0.65,0.7,0.75,0.8,0.85,0.9,0.95 or 1 part.Grass-leaved sweetflag essential oil has dampness elimination
The effect of calmness, swelling and pain relieving.
The typical but non-limiting mass fraction of Peppermint essential oil as 0.05,0.08,0.1,0.12,0.15,0.18,
0.2,0.22,0.25,0.28,0.3,0.32,0.35,0.38,0.4,0.42,0.45,0.48 or 0.5 part.Peppermint essential oil has
The effect of antiallergic, promoting eruption, sterilization and analgesia.
The typical but non-limiting mass fraction of Lavender as 0.1,0.15,0.2,0.25,0.3,0.35,
0.4,0.45,0.5,0.55,0.6,0.65,0.7,0.75,0.8,0.85,0.9,0.95 or 1 part.Lavender, which has, to kill
The effect of bacterium, disinfection, calmness and removing toxic substances, the effect of while cytothesis can also being accelerated, promote rehabilitation, prevent scar.
The typical but non-limiting mass fraction of chamomile essential oil as 0.5,0.55,0.6,0.65,0.7,0.75,
0.8、0.85、0.9、0.95、1、1.05、1.1、1.15、1.2、1.25、1.3、1.35、1.4、1.45、1.5、1.55、1.6、
1.65,1.7,1.75,1.8,1.85,1.9,1.95 or 2 parts.Chamomile essential oil has the effect of promoting to sleep, anti-inflammatory anti-itch.
The typical but non-limiting mass fraction of vitamin E as 10,10.5,11,11.5,12,12.5,13,13.5,
14,14.5,15,15.5,16,16.5,17,17.5,18,18.5,19,19.5 or 20 parts.Vitamin E has strong oxidation,
Infringement of the skin to Green Tea Extract, ultraviolet light and pollutant can be helped, elasticity of skin is kept.
The typical but non-limiting mass fraction of Sweet Almond Oil as 20,20.5,21,21.5,22,22.5,23,
23.5,24,24.5,25,25.5,26,26.5,27,27.5,28,28.5,29,29.5 or 30 parts.Sweet Almond Oil has lubrication clear
Refreshing, pro-skin, it is antipruritic, go the effect of dry and anti-inflammatory.
The typical but non-limiting mass fraction of wheat-germ oil as 20,20.5,21,21.5,22,22.5,23,
23.5,24,24.5,25,25.5,26,26.5,27,27.5,28,28.5,29,29.5 or 30 parts.Wheat-germ oil, which has, to be adjusted
Fat secretion, anti-oxidant and moisturizing effect.
The typical but non-limiting mass fraction of SIMMONDSIA CHINENSIS SEED OIL as 10,10.5,11,11.5,12,12.5,13,
13.5、14、14.5、15、15.5、16、16.5、17、17.5、18、18.5、19、19.5、20、20.5、21、21.5、22、22.5、
23,23.5,24,24.5 or 25 parts.SIMMONDSIA CHINENSIS SEED OIL has strong permeability, can moisten moisturizing, maintaining skin.
In the present invention, essential oil is 99.9% original effect that ensure that plant where the essence of vegetation.The present invention carries
The acne removal essential oil composition of confession, is compounded by a variety of essential oils, and is aided with vitamin E and a variety of base oils are combined, and is made full use of
The small molecule of essential oil and the advantage of high osmosis penetrate to the skin rapidly in blood, and 3 seconds reachable epidermis can arrive for 6 seconds
Up to skin corium, enter within 3 minutes subcutaneous tissue, reach within 6 minutes the blood circulation that blood carries out whole body, the efficacy of a drug is gone directly lesion, rapidly
Alleviate symptom, and without chemical addition agent, natural green, pure health is safe and efficient, has no toxic side effect, and allows skin no pollution.
Acne removal essential oil composition provided by the invention is on the basis that traditional Chinese medicine compatibility theory and essential oil blending technology are combined
Under, pass through Forsythia suspense essential oil, Jing Jie essential oils, frutus cnidii essential oil, grass-leaved sweetflag essential oil, Peppermint essential oil, Lavender, chamomile essence
It is flat can not only to adjust sebum secretion for oil, Sweet Almond Oil, vitamin E, wheat-germ oil and the mutual coordinated of SIMMONDSIA CHINENSIS SEED OIL
Weighing apparatus, anti-inflammatory sterilization, active cell self maintenance, and can desalinate acne print, skin of releiving, while safe and efficient are nontoxic secondary to make
With patient suffering can be effectively relieved.
The present invention composition further include a variety of non-essential components, they be aesthetically easier be accepted, or
The composition is set to use benefit with additional.This variety of constituents are well known to professionals in the field.They include but
It is not limited to fatty alcohol, sodium chloride, ethyl alcohol, pH adjusting agent, colorant, suspending agent, sun-screening agent, thickener and viscosity modifier etc..
In the preferred embodiment of the present invention, acne removal essential oil composition further includes 0.2-1 parts of auxiliary agent.
In the present invention, the typical but non-limiting mass fraction of auxiliary agent as 0.2,0.25,0.3,0.35,0.4,
0.45,0.5,0.55,0.6,0.65,0.7,0.75,0.8,0.85,0.9,0.95 or 1 part.
In present invention further optimization embodiment, auxiliary agent include in gelling agent, moisturizer or preservative at least
It is a kind of.
[gelling agent]
In a kind of preferred embodiment of the present invention, gelling agent is water-soluble high-molecular substance, including but not limited to naturally
Polymer substance, modified natural polymer substance and synthetic high polymer matter.
Water-soluble high-molecular substance is preferably cellulose family and its derivative, such as methylcellulose, hydroxypropyl methyl fiber
Element, hydroxypropyl methylcellulose phthalate, hydroxypropyl methyl cellulose succinate, hydroxymethyl ethylcellulose, carboxylic
Methylethylcellulose, sodium carboxymethylcellulose, hydroxyethyl cellulose, cellulose acetate phthalate.
It includes but not limited to polyethylene glycol, polyvinyl alcohol, polyvinylpyrrolidone, polyethylene acetal two to synthesize macromolecule
Ethylamino mistake acid esters, Eudragit E100-E, Eudragit E100-RS, methyl
Acrylic copolymer-L, methacrylic acid copolymer-LD, methacrylic acid copolymer-S and carboxyl vinyl polymer etc..
Natural polymer and carbohydrate include but not limited to Arabic gum, mosanom, propylene glycol alginate, agar, gelatin and
Xanthans etc..
In present invention further optimization embodiment, gelling agent be selected from methylcellulose, hydroxypropyl methyl cellulose,
The composition of one or more of hydroxypropyl cellulose, polyethylene glycol or polyvinyl alcohol.
[moisturizer]
In a preferred embodiment of the invention, moisturizing and be selected from polyol agent.
Polyalcohol includes but not limited to glycol and Aethoxy Sklerol.
Glycol is selected from diethylene glycol, dipropylene glycol, ethylene glycol, propylene glycol, hexylene glycol, isoprene, butanediol, penta 2
The composition of one or more of alcohol, butanediol, 1,2- propane diols, pentane diol, decanediol and dodecanediol.
In the preferred embodiment of the present invention, the number-average molecular weight of Aethoxy Sklerol is 150-600, such as polyethylene glycol
300 and polyglycereol 500 etc..
[preservative]
In the preferred embodiment of the present invention, preservative includes but not limited to Phenoxyethanol and/or ethylhexyl
Glycerine.
According to the second aspect of the invention, the present invention provides the preparation methods of above-mentioned acne removal essential oil composition, including
Following steps：
By Forsythia suspense essential oil, schizonepeta essential oil, frutus cnidii essential oil, grass-leaved sweetflag essential oil, Peppermint essential oil, Lavender, chamomile
Essential oil, Sweet Almond Oil, vitamin E, wheat-germ oil, SIMMONDSIA CHINENSIS SEED OIL and optional auxiliary agent are uniformly mixed, and obtain acne removal essential oil
Composition.
The preparation method of acne removal essential oil composition provided by the invention is simple for process, easy to operate, and it is big to be suitable for industrialization
Production, can effectively improve production efficiency.
In the preferred embodiment of the present invention, first by Sweet Almond Oil, vitamin E, wheat-germ oil, SIMMONDSIA CHINENSIS SEED OIL
It is uniformly mixed, sequentially adds Forsythia suspense essential oil, chamomile essential oil, Jing Jie essential oils, grass-leaved sweetflag essential oil, Lavender, frutus cnidii
Essential oil, Peppermint essential oil and optional auxiliary agent are uniformly mixed.
Acne removal essential oil composition provided by the invention sequentially adds in container from big to small according to each component ratio, by it,
It after sealing, firmly rolls, so that all components is uniformly mixed, obtain acne removal essential oil composition.
The application method of acne removal essential oil composition provided by the invention is：Acne removal essential oil composition is coated on and is cleaned up
Small pox at, and massage make its absorption, once in the morning and once at night, you can.
The application method of acne removal essential oil composition provided by the invention is simple, and medication is convenient, has broad application prospects.
The third object of the present invention is to provide application of the above-mentioned acne removal essential oil composition in skin care item.
In the present invention, skin care item include but not limited to face cream, facial mask and shin moisturizer etc..
Technical solution provided by the invention is further described with reference to embodiment and comparative example.
Embodiment 1
Present embodiments provide a kind of acne removal essential oil composition, including following component according to the mass fraction：Forsythia suspense essential oil 1
Part, 1 part of schizonepeta essential oil, 0.1 part of frutus cnidii essential oil, 1 part of grass-leaved sweetflag essential oil, 0.05 part of Peppermint essential oil, 1 part of Lavender, ocean
15.45 parts of 0.5 part of camomile essential oil, 20 parts of Sweet Almond Oil, 20 parts of vitamin E, 30 parts of wheat-germ oil and SIMMONDSIA CHINENSIS SEED OIL.
Embodiment 2
Present embodiments provide a kind of acne removal essential oil composition, including following component according to the mass fraction：Forsythia suspense essential oil 5
Part, 0.1 part of schizonepeta essential oil, 1 part of frutus cnidii essential oil, 0.1 part of grass-leaved sweetflag essential oil, 0.5 part of Peppermint essential oil, 0.1 part of Lavender,
21.2 parts of 2 parts of chamomile essential oil, 30 parts of Sweet Almond Oil, 10 parts of vitamin E, 20 parts of wheat-germ oil and SIMMONDSIA CHINENSIS SEED OIL.
Embodiment 3
Present embodiments provide a kind of acne removal essential oil composition, including following component according to the mass fraction：Forsythia suspense essential oil 2
Part, 1 part of schizonepeta essential oil, 0.2 part of frutus cnidii essential oil, 0.8 part of grass-leaved sweetflag essential oil, 0.05 part of Peppermint essential oil, Lavender 0.8
20 parts of part, 1 part of chamomile essential oil, 24 parts of Sweet Almond Oil, 16 parts of vitamin E, 24.15 parts of wheat-germ oil and SIMMONDSIA CHINENSIS SEED OIL.
Embodiment 4
Present embodiments provide a kind of acne removal essential oil composition, including following component according to the mass fraction：Forsythia suspense essential oil 4
Part, 0.4 part of schizonepeta essential oil, 0.7 part of frutus cnidii essential oil, 0.2 part of grass-leaved sweetflag essential oil, 0.45 part of Peppermint essential oil, Lavender
0.15 part, 1 part of chamomile essential oil, 28.1 parts of Sweet Almond Oil, 15 parts of vitamin E, 25 parts of wheat-germ oil and SIMMONDSIA CHINENSIS SEED OIL 25
Part.
Embodiment 5
Present embodiments provide a kind of acne removal essential oil composition, including following component according to the mass fraction：Forsythia suspense essential oil 3
Part, 0.8 part of schizonepeta essential oil, 0.4 part of frutus cnidii essential oil, 0.7 part of grass-leaved sweetflag essential oil, 0.2 part of Peppermint essential oil, Lavender 0.7
22 parts of part, 1 part of chamomile essential oil, 25 parts of Sweet Almond Oil, 20 parts of vitamin E, 26.2 parts of wheat-germ oil and SIMMONDSIA CHINENSIS SEED OIL.
Embodiment 6
Present embodiments provide a kind of acne removal essential oil composition, including following component according to the mass fraction：Forsythia suspense essential oil 4
Part, 0.5 part of schizonepeta essential oil, 0.6 part of frutus cnidii essential oil, 0.3 part of grass-leaved sweetflag essential oil, 0.4 part of Peppermint essential oil, Lavender 0.3
17.9 parts of part, 1 part of chamomile essential oil, 30 parts of Sweet Almond Oil, 15 parts of vitamin E, 20 parts of wheat-germ oil and SIMMONDSIA CHINENSIS SEED OIL.
Embodiment 7
Present embodiments provide a kind of acne removal essential oil composition, including following component according to the mass fraction：Forsythia suspense essential oil
3.5 parts, 0.6 part of schizonepeta essential oil, 0.5 part of frutus cnidii essential oil, 0.5 part of grass-leaved sweetflag essential oil, 0.3 part of Peppermint essential oil, Lavender
0.5 part, 1.5 parts of chamomile essential oil, 27.6 parts of Sweet Almond Oil, 18 parts of vitamin E, 25 parts of wheat-germ oil and SIMMONDSIA CHINENSIS SEED OIL 22
Part.
Embodiment 8
Present embodiments provide a kind of preparation method of acne removal essential oil composition, the acne removal essential oil group that embodiment 1-7 is provided
Object is closed to be prepared in accordance with the following steps：
First Sweet Almond Oil, vitamin E, wheat-germ oil, SIMMONDSIA CHINENSIS SEED OIL are put into closed container and are uniformly mixed, then successively
Be added Forsythia suspense essential oil, chamomile essential oil, schizonepeta essential oil, grass-leaved sweetflag essential oil, Lavender, frutus cnidii essential oil, Peppermint essential oil and
Optional auxiliary agent, firmly rolls, and so that above-mentioned various ingredients is uniformly mixed, obtains acne removal essential oil composition.
Comparative example 1
This comparative example provides a kind of acne removal essential oil composition, this comparative example with embodiment 7 the difference is that, Fructus Forsythiae
0.1 part of essential oil, 3 parts of schizonepeta essential oil, 2 parts of frutus cnidii essential oil, 3 parts of grass-leaved sweetflag essential oil, 1 part of Peppermint essential oil, 3 parts of Lavender,
0.1 part of chamomile essential oil, 40 parts of Sweet Almond Oil, 2 parts of vitamin E, 40 parts of wheat-germ oil, 5.8 parts of SIMMONDSIA CHINENSIS SEED OIL.
Comparative example 2
This comparative example provides a kind of acne removal essential oil composition, this comparative example with embodiment 7 the difference is that, Fructus Forsythiae
10 parts of essential oil, 0.05 part of schizonepeta essential oil, 0.05 part of frutus cnidii essential oil, 0.05 part of grass-leaved sweetflag essential oil, 0.01 part of Peppermint essential oil smoke clothing
0.04 part of careless essential oil, 5 parts of chamomile essential oil, 15 parts of Sweet Almond Oil, 30 parts of vitamin E, 9.8 parts of wheat-germ oil, SIMMONDSIA CHINENSIS SEED OIL
30 parts.
Comparative example 3
This comparative example provides a kind of acne removal essential oil composition, this comparative example with embodiment 7 the difference is that, not plus
Enter Forsythia suspense essential oil.
Comparative example 4
This comparative example provides a kind of acne removal essential oil composition, this comparative example with embodiment 7 the difference is that, not plus
Enter chamomile essential oil.
Comparative example 5
This comparative example provides a kind of acne removal essential oil composition, this comparative example with embodiment 7 the difference is that, not plus
Enter vitamin E.
Comparative example 6
This comparative example provides a kind of acne removal essential oil composition, this comparative example with embodiment 7 the difference is that, not plus
Enter schizonepeta essential oil.
Comparative example 7
This comparative example provides a kind of acne removal essential oil composition, this comparative example with embodiment 7 the difference is that, not plus
Enter frutus cnidii essential oil.
Comparative example 8
This comparative example provides a kind of acne removal essential oil composition, this comparative example with embodiment 7 the difference is that, not plus
Enter grass-leaved sweetflag essential oil.
Comparative example 9
This comparative example provides a kind of acne removal essential oil composition, this comparative example with embodiment 7 the difference is that, not plus
Enter Peppermint essential oil.
Comparative example 10
This comparative example provides a kind of acne removal essential oil composition, this comparative example with embodiment 7 the difference is that, not plus
Enter Lavender.
Comparative example 11
This comparative example provides a kind of acne removal essential oil composition, this comparative example with embodiment 7 the difference is that, not plus
Enter Sweet Almond Oil.
Comparative example 12
This comparative example provides a kind of acne removal essential oil composition, this comparative example with embodiment 7 the difference is that, not plus
Enter wheat-germ oil.
Comparative example 13
This comparative example provides a kind of acne removal essential oil composition, this comparative example with embodiment 7 the difference is that, not plus
Enter SIMMONDSIA CHINENSIS SEED OIL.
Comparative example 14
This comparative example provides a kind of acne removal essential oil composition, this comparative example with embodiment 7 the difference is that, Fructus Forsythiae
Essential oil is 7.4 parts, and schizonepeta essential oil, frutus cnidii essential oil, grass-leaved sweetflag essential oil, Peppermint essential oil, Lavender and chamomile are not added
Essential oil.
Comparative example 15
This comparative example provides a kind of acne removal essential oil composition, this comparative example with embodiment 7 the difference is that, schizonepeta
Essential oil is 7.4 parts, and Forsythia suspense essential oil, frutus cnidii essential oil, grass-leaved sweetflag essential oil, Peppermint essential oil, Lavender and chamomile are not added
Essential oil.
Comparative example 16
This comparative example provides a kind of acne removal essential oil composition, this comparative example with embodiment 7 the difference is that, cnidium monnieri
Sub- essential oil is 7.4 parts, and Forsythia suspense essential oil, schizonepeta essential oil, grass-leaved sweetflag essential oil, Peppermint essential oil, Lavender and chamomile are not added
Essential oil.
Comparative example 17
This comparative example provides a kind of acne removal essential oil composition, this comparative example with embodiment 7 the difference is that, stone Chang
Pu essential oil is 7.4 parts, and Forsythia suspense essential oil, frutus cnidii essential oil, schizonepeta essential oil, Peppermint essential oil, Lavender and chamomile are not added
Essential oil.
Comparative example 18
This comparative example provides a kind of acne removal essential oil composition, this comparative example with embodiment 7 the difference is that, peppermint
Essential oil is 7.4 parts, and Forsythia suspense essential oil, frutus cnidii essential oil, schizonepeta essential oil, grass-leaved sweetflag essential oil, Lavender and chamomile are not added
Essential oil.
Comparative example 19
This comparative example provides a kind of acne removal essential oil composition, this comparative example with embodiment 7 the difference is that, smoke clothing
Careless essential oil is 7.4 parts, and Forsythia suspense essential oil, frutus cnidii essential oil, schizonepeta essential oil, grass-leaved sweetflag essential oil, Peppermint essential oil and chamomile are not added
Essential oil.
Comparative example 20
This comparative example provides a kind of acne removal essential oil composition, this comparative example with embodiment 7 the difference is that, ocean is sweet
Chrysanthemum essential oil is 7.4 parts, and Forsythia suspense essential oil, frutus cnidii essential oil, schizonepeta essential oil, grass-leaved sweetflag essential oil, Peppermint essential oil and lavender are not added
Essential oil.
Comparative example 21
This comparative example provides a kind of blemish clearing gel, which is commercially available Clindamycin Phosphate Gel.
Comparative example 22
This comparative example provides a kind of PBS solution.
The acne removal essential oil group that the preparation method for the acne removal essential oil composition that above-mentioned comparative example 1-20 is provided is provided with embodiment 7
The preparation method for closing object is identical, and details are not described herein.
Test example 1
In order to verify the fungistatic effect of acne removal essential oil composition provided by the invention, the anti-acne that spy provides embodiment 1-7
The blemish clearing gel and solution point that the acne removal essential oil composition and comparative example 21-22 that essential oil composition and comparative example 1-20 are provided provide
Not carry out acne pathogenic bacteria In Vitro Bacteriostatic test.
1.1 bacterial strain
Propionibacterium acnes reference culture, staphylococcus aureus reference culture and Escherichia coli reference culture.
1.2 test methods one
Three kinds of bacterial strains are first prepared into 10 with 0.03mol/L PBS solutions respectively5The bacteria suspension of cfu/ml is spare, then root
Embodiment 1-7 and comparative example the 1-20 acne removal essential oil provided are combined respectively according to suspension quantitative method as defined in QB/T2738-2012
The PBS solution that the blemish clearing gel and comparative example 22 that object, comparative example 21 provide provide carries out the evaluation of acne pathogenic bacteria bacteriostasis rate, as a result
As shown in table 1：
1 acne pathogenic bacteria bacteriostasis rate tables of data of table
As it can be seen from table 1 when the acne removal essential oil composition that embodiment 1-7 is provided acts on 10min with corresponding bacteria suspension,
80% is higher than to the bacteriostasis rate of staphylococcus aureus, 75% is higher than to the bacteriostasis rate of propionibacterium acnes, to Escherichia coli
Bacteriostasis rate is higher than 95%, this illustrates that acne removal essential oil composition provided by the invention can significantly inhibit the growth of acne pathogenic bacteria,
Sebum secretion balance is adjusted, the pain of patient is effectively relieved.
Acne removal essential oil composition provided by the invention is can be seen that gold by the comparison of embodiment 1-7 and comparative example 22
Staphylococcus aureus, propionibacterium acnes and the inhibiting effect of Escherichia coli are notable.
Acne removal essential oil composition provided by the invention is can be seen that gold by the comparison of embodiment 1-7 and comparative example 21
Staphylococcus aureus, propionibacterium acnes and a little higher than Clindamycin Phosphate Gel of the inhibiting effect of Escherichia coli, and it is adopted
It is formed with the essential oil of natural green and formulation of base oil, it is without any side effects, it is healthier, it is safer, it is more environmentally friendly.
Acne removal essential oil composition provided by the invention is can be seen that by the comparison of embodiment 1-7 and comparative example 1-20 to exist
Under the basis that traditional Chinese medicine compatibility and essential oil allotment are combined, pass through the Forsythia suspense essential oil of extra fine quality number, Jing Jie essential oils, frutus cnidii
Essential oil, grass-leaved sweetflag essential oil, Peppermint essential oil, Lavender, chamomile essential oil, Sweet Almond Oil, vitamin E, wheat-germ oil and
The mutual coordinated of SIMMONDSIA CHINENSIS SEED OIL, more to the inhibiting effect of staphylococcus aureus, propionibacterium acnes and Escherichia coli
Significantly, patient suffering can more be effectively relieved.
1.3 test methods two
Three kinds of bacterial strains are prepared into 10 according to 1.2 method5The bacteria suspension of cfu/ml, then according to QB/T2738-2012
Acne removal essential oil composition that defined antibacterial ring size evaluation method respectively provides embodiment 1-7 and comparative example 1-20, comparative example 21
The PBS solution that the blemish clearing gel and comparative example 22 of offer provide carries out acne pathogenic bacteria inhibition zone diameter and measures, as a result such as 2 institute of table
Show：
2 acne pathogenic bacteria inhibition zone diameter tables of data of table
From table 2 it can be seen that the acne removal essential oil composition that embodiment 1-7 is provided is straight to the antibacterial ring size of staphylococcus aureus
Diameter is more than 22mm, and the inhibition zone diameter of propionibacterium acnes is more than 24mm, is more than 34mm to the inhibition zone diameter of Escherichia coli, this
Illustrate that acne removal essential oil composition provided by the invention can significantly inhibit the growth of acne pathogenic bacteria, adjust sebum secretion balance,
The pain of patient is effectively relieved.
Acne removal essential oil composition provided by the invention is can be seen that gold by the comparison of embodiment 1-7 and comparative example 22
Staphylococcus aureus, propionibacterium acnes and Escherichia coli inhibiting effect are notable.
Acne removal essential oil composition provided by the invention is can be seen that gold by the comparison of embodiment 1-7 and comparative example 21
Staphylococcus aureus, propionibacterium acnes and the inhibition zone diameter of Escherichia coli are antibacterial slightly larger than Clindamycin Phosphate Gel
Ring diameter, and it uses the essential oil of natural green and formulation of base oil to form, it is without any side effects, it is healthier, it is safer, more
Environmental protection, it is more preferable to the inhibiting effect of acne pathogenic bacteria.
Acne removal essential oil composition provided by the invention is can be seen that by the comparison of embodiment 1-7 and comparative example 1-20 to exist
Under the basis that traditional Chinese medicine compatibility and essential oil allotment are combined, pass through the Forsythia suspense essential oil of extra fine quality number, Jing Jie essential oils, frutus cnidii
Essential oil, grass-leaved sweetflag essential oil, Peppermint essential oil, Lavender, chamomile essential oil, Sweet Almond Oil, vitamin E, wheat-germ oil and
The mutual coordinated of SIMMONDSIA CHINENSIS SEED OIL, more to the inhibiting effect of staphylococcus aureus, propionibacterium acnes and Escherichia coli
Significantly, patient suffering can more be effectively relieved.
Test example 2
For the practical effect of testing example 1-7 and comparative example 1-22 the anti-acne substance provided, according to《Cosmetics connect
Touch property dermatitis diagnostic criteria and treatment principle》Routinely patients with acne 2900 carries out crowd's investigation on probation to screening face, will
2900 target users are divided into 29 groups, and every group of 100 people, 1-7 groups use the acne removal essential oil composition that embodiment 1-7 is provided respectively,
8-29 groups are respectively using the acne removal essential oil composition of comparative example 1-20 groups offer, the blemish clearing gel and comparative example of the offer of comparative example 21
22 PBS solutions provided, application method are：After the daily face cleaning of patients with acne Cuo is treated coated on site of disease with by anti-acne substance
Sore, it is sooner or later each to smear primary, surrounding on probation, while filling in investigation volume, last statistical result.Examine the anti-acne of anti-acne compound essential oil
Effect, the results are shown in Table 3：
3 patients with acne using effect evaluation table of table
Note：Effective standard is that acne largely disappears, and occurs without new acne；Effective standard is acne part hour
And remission, occasionally there is new acne to occur；Invalid standard is acne phenomenon without significant change.
From table 31 group can be seen that acne removal essential oil composition provided by the invention with 29 groups of comparison being capable of rapid osmotic
Skin inhibits the growth of acne pathogenic bacteria, adjusts sebum secretion balance, and the effective percentage after four weeks reaches 100%.
Acne removal essential oil composition provided by the invention is can be seen that the effective of acne by 1-7 groups and 28 groups compare
The a little higher than Clindamycin Phosphate Gel of speed, therapeutic effect are also slightly better than Clindamycin Phosphate Gel.
Acne removal essential oil composition provided by the invention is can be seen that by the comparison of 1-7 groups and 8-27 groups in traditional Chinese medicine to match
5 and the basis that is combined of essential oil allotment under, pass through the Forsythia suspense essential oil of extra fine quality number, Jing Jie essential oils, frutus cnidii essential oil, stone
Calamus essential oil, Peppermint essential oil, Lavender, chamomile essential oil, Sweet Almond Oil, vitamin E, wheat-germ oil and SIMMONDSIA CHINENSIS SEED OIL
Mutual coordinated, to acne it is effective faster, therapeutic effect is more preferably.
In addition, this time investigation also investigates facial excitement, investigation result shows that 1-27 group crowds are non-stimulated
Sense record, and 28 groups of crowds have 10 people to think there is obvious stimulation sense, 30 people think slightly excitement, this explanation is provided by the invention
Acne removal essential oil composition natural green, it is safe and efficient, it has no toxic side effect, will not affect human health.
Finally it should be noted that：The above embodiments are only used to illustrate the technical solution of the present invention., rather than its limitations；To the greatest extent
Present invention has been described in detail with reference to the aforementioned embodiments for pipe, it will be understood by those of ordinary skill in the art that：Its according to
So can with technical scheme described in the above embodiments is modified, either to which part or all technical features into
Row equivalent replacement；And these modifications or replacements, various embodiments of the present invention technology that it does not separate the essence of the corresponding technical solution
The range of scheme.
Claims (10)
1. a kind of acne removal essential oil composition, which is characterized in that including following component according to the mass fraction：1-5 parts of Forsythia suspense essential oil,
0.1-1 parts of schizonepeta essential oil, 0.1-1 parts of frutus cnidii essential oil, 0.1-1 parts of grass-leaved sweetflag essential oil, 0.05-0.5 parts of Peppermint essential oil, lavender
0.1-1 parts of essential oil, 0.5-2 parts of chamomile essential oil, 20-30 parts of Sweet Almond Oil, 10-20 parts of vitamin E, wheat-germ oil 20-30
Part, 10-25 parts of SIMMONDSIA CHINENSIS SEED OIL, the sum of above-mentioned each component is 100 parts.
2. acne removal essential oil composition according to claim 1, which is characterized in that including according to the mass fraction such as the following group
Point：2-4 parts of Forsythia suspense essential oil, 0.4-1 parts of schizonepeta essential oil, 0.2-0.7 parts of frutus cnidii essential oil, 0.2-0.8 parts of grass-leaved sweetflag essential oil, peppermint
0.05-0.45 parts of essential oil, 0.15-0.8 parts of Lavender, 1-2 parts of chamomile essential oil, 20-30 parts of Sweet Almond Oil, vitamin E
10-20 parts, 20-30 parts of wheat-germ oil, 10-25 parts of SIMMONDSIA CHINENSIS SEED OIL, the sum of above-mentioned each component is 100 parts.
3. acne removal essential oil composition according to claim 1, which is characterized in that including according to the mass fraction such as the following group
Point：3-4 parts of Forsythia suspense essential oil, 0.5-0.8 parts of schizonepeta essential oil, 0.4-0.6 parts of frutus cnidii essential oil, 0.3-0.7 parts of grass-leaved sweetflag essential oil are thin
0.2-0.4 parts of lotus essential oil, 0.3-0.7 parts of Lavender, 1-2 parts of chamomile essential oil, 20-30 parts of Sweet Almond Oil, vitamin E
10-20 parts, 20-30 parts of wheat-germ oil, 10-25 parts of SIMMONDSIA CHINENSIS SEED OIL, the sum of above-mentioned each combination is 100 parts.
4. according to claim 1-3 any one of them acne removal essential oil compositions, which is characterized in that further include according to the mass fraction
0.2-1 parts of auxiliary agent；
Preferably, the auxiliary agent includes gelling agent, moisturizer or at least one of the preservatives.
5. acne removal essential oil composition according to claim 4, which is characterized in that the gelling agent be selected from methylcellulose,
At least one of hydroxypropyl methyl cellulose, hydroxypropyl cellulose, polyethylene glycol or polyvinyl alcohol.
6. acne removal essential oil composition according to claim 4, which is characterized in that the moisturizer is selected from diethylene glycol, two
At least one of propylene glycol, ethylene glycol, hexylene glycol, isoprene, butanediol or pentanediol.
7. acne removal essential oil composition according to claim 4, which is characterized in that the preservative be Phenoxyethanol and/or
Sensiva SC50.
8. according to the preparation method of claim 1-7 any one of them acne removal essential oil compositions, which is characterized in that including as follows
Step：
By Forsythia suspense essential oil, schizonepeta essential oil, frutus cnidii essential oil, grass-leaved sweetflag essential oil, Peppermint essential oil, Lavender, chamomile essential oil,
Sweet Almond Oil, vitamin E, wheat-germ oil, SIMMONDSIA CHINENSIS SEED OIL and optional auxiliary agent are uniformly mixed, and obtain acne removal essential oil combination
Object.
9. the preparation method of acne removal essential oil composition according to claim 8, which is characterized in that first by Sweet Almond Oil, dimension
Raw element E, wheat-germ oil, SIMMONDSIA CHINENSIS SEED OIL are uniformly mixed, and sequentially add Forsythia suspense essential oil, chamomile essential oil, schizonepeta essential oil, stone Chang
Pu essential oil, Lavender, frutus cnidii essential oil, Peppermint essential oil and optional auxiliary agent are uniformly mixed.
10. according to application of the claim 1-7 any one of them acne removal essential oil compositions in skin care item.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111700825A (en) * | 2020-06-29 | 2020-09-25 | 上海中医药大学 | Oily composition for oral health care, preparation method and application thereof |
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| CN1742752A (en) * | 2005-10-08 | 2006-03-08 | 晏四平 | Atomizing agent containing medicinal plant oil |
| CN105112180A (en) * | 2015-09-09 | 2015-12-02 | 中国科学院植物研究所 | Natural plant flower fragrance type essential oil soap having bacteriostatic function and producing method thereof |
| CN105832568A (en) * | 2016-03-26 | 2016-08-10 | 佛山市芊茹化妆品有限公司 | Solid micro-emulsion, preparation method and application thereof |
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| CN1742752A (en) * | 2005-10-08 | 2006-03-08 | 晏四平 | Atomizing agent containing medicinal plant oil |
| CN105112180A (en) * | 2015-09-09 | 2015-12-02 | 中国科学院植物研究所 | Natural plant flower fragrance type essential oil soap having bacteriostatic function and producing method thereof |
| CN105112180B (en) * | 2015-09-09 | 2017-12-01 | 中国科学院植物研究所 | Natural plants floral type essential oil soap with bacteria resistance function and preparation method thereof |
| CN105832568A (en) * | 2016-03-26 | 2016-08-10 | 佛山市芊茹化妆品有限公司 | Solid micro-emulsion, preparation method and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111700825A (en) * | 2020-06-29 | 2020-09-25 | 上海中医药大学 | Oily composition for oral health care, preparation method and application thereof |
| CN111700825B (en) * | 2020-06-29 | 2022-07-01 | 上海中医药大学 | Oily composition for oral health care, preparation method and application thereof |
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