CN108379127B - Acne-removing essential oil composition and preparation method and application thereof - Google Patents
Acne-removing essential oil composition and preparation method and application thereof Download PDFInfo
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Abstract
The invention provides an acne-removing essential oil composition and a preparation method and application thereof, and relates to the technical field of medical cosmetics, the acne-removing essential oil composition comprises 1-5 parts by weight of fructus forsythiae essential oil, 0.1-1 part by weight of schizonepeta essential oil, 0.1-1 part by weight of fructus cnidii essential oil, 0.1-1 part by weight of rhizoma acori graminei essential oil, 0.05-0.5 part by weight of mint essential oil, 0.1-1 part by weight of lavender essential oil, 0.5-2 parts by weight of chamomile essential oil, 20-30 parts by weight of sweet potato oil, 10-20 parts by weight of vitamin E, 20-30 parts by weight of wheat germ oil and 10-25 parts by weight of jojoba oil, and the technical problems that the existing western medicine for removing acne has large toxic and side effects and high cost, the single action of single-component essential oil and an unobvious curative effect are solved, the acne-removing essential oil composition provided by the invention can not only, but also can fade acne marks and relieve skin, is safe and efficient, has no toxic or side effect, and can quickly relieve the pain of patients.
Description
Technical Field
The invention relates to the technical field of medical cosmetics, in particular to an acne-removing essential oil composition and a preparation method and application thereof.
Background
Acne is commonly known as whelk, is a chronic inflammatory dermatosis of hair follicles and sebaceous glands, is a common disease and a frequently encountered disease, and is particularly easy to occur in adolescent men and women. It is manifested as comedones, papules or pustules on the face, and comedones, whiteheads and pachyons on the face, head and back. Acne occurs in close relation to factors such as hyperseborrhea, blockage of pilosebaceous ducts, bacterial infection and inflammatory reactions. After adolescence, the level of androgen, particularly testosterone, in a human body is rapidly increased, the development of sebaceous glands is promoted, and a large amount of sebum is produced. Meanwhile, abnormal keratinization of the pilosebaceous canal causes the canal to be blocked, sebum is obstructed to be discharged, and a keratoplug, namely micro acne, is formed. A number of microorganisms in the hair follicle, particularly propionibacterium acnes, multiply in number, and lipases produced by propionibacterium acnes break down sebum to produce free fatty acids, while chemotactic inflammatory cells and mediators, ultimately inducing and exacerbating the inflammatory response.
At present, the acne-removing local external medicine comprises western medicines such as tretinoin, benzoyl peroxide, antibiotics, azelaic acid, sulfur lotion and the like, and the western medicines have large toxic and side effects and high cost; most of acne-removing essential oils on the market are prepared by mixing single essential oil and base oil, and have single effect and insignificant curative effect.
In view of the above, the present invention is particularly proposed.
Disclosure of Invention
The invention aims to provide an acne-removing essential oil composition to solve the technical problems that an existing acne-removing medicine is western medicine or single-prescription essential oil, the western medicine is large in toxic and side effects and high in cost, the single-prescription essential oil is single in effect, and the curative effect is not obvious.
The acne-removing essential oil composition provided by the invention comprises the following components in parts by mass: 1-5 parts of fructus forsythiae essential oil, 0.1-1 part of schizonepeta essential oil, 0.1-1 part of fructus cnidii essential oil, 0.1-1 part of rhizoma acori graminei essential oil, 0.05-0.5 part of mint essential oil, 0.1-1 part of lavender essential oil, 0.5-2 parts of chamomile essential oil, 20-30 parts of sweet almond oil, 10-20 parts of vitamin E, 20-30 parts of wheat germ oil and 10-25 parts of jojoba oil, wherein the sum of the components is 100 parts.
Further, the acne removing essential oil composition comprises the following components in parts by weight: 2-4 parts of fructus forsythiae essential oil, 0.4-1 part of schizonepeta essential oil, 0.2-0.7 part of fructus cnidii essential oil, 0.2-0.8 part of rhizoma acori graminei essential oil, 0.05-0.45 part of mint essential oil, 0.15-0.8 part of lavender essential oil, 1-2 parts of chamomile essential oil, 20-30 parts of sweet almond oil, 10-20 parts of vitamin E, 20-30 parts of wheat germ oil and 10-25 parts of jojoba oil, wherein the sum of the components is 100 parts.
Further, the acne removing essential oil composition comprises the following components in parts by weight: 3-4 parts of fructus forsythiae essential oil, 0.5-0.8 part of schizonepeta essential oil, 0.4-0.6 part of fructus cnidii essential oil, 0.3-0.7 part of rhizoma acori graminei essential oil, 0.2-0.4 part of mint essential oil, 0.3-0.7 part of lavender essential oil, 1-2 parts of chamomile essential oil, 20-30 parts of sweet almond oil, 10-20 parts of vitamin E, 20-30 parts of wheat germ oil and 10-25 parts of jojoba oil, wherein the sum of the above components is 100 parts.
Further, the acne-removing essential oil composition also comprises 0.2-1 part by mass of an auxiliary agent;
preferably, the adjuvant comprises at least one of a gelling agent, a humectant, or a preservative.
Further, the gelling agent is at least one selected from methylcellulose, hydroxypropyl cellulose, polyethylene glycol or polyvinyl alcohol.
Further, the humectant is selected from at least one of dipropylene glycol, ethylene glycol, hexylene glycol, isoprene glycol, butylene glycol or pentylene glycol.
Further, the preservative is phenoxyethanol and/or ethylhexyl glycerin.
The invention also aims to provide a preparation method of the acne-removing essential oil composition, which comprises the following steps:
mixing fructus forsythiae essential oil, herba Schizonepetae essential oil, fructus Cnidii essential oil, rhizoma Acori Graminei essential oil, herba Menthae essential oil, Lavender essential oil, flos Matricariae Chamomillae essential oil, sweet almond oil, vitamin E, wheat germ oil, jojoba oil and optional adjuvants uniformly to obtain the acne removing essential oil composition.
Further, sweet almond oil, vitamin E, wheat germ oil and jojoba oil are uniformly mixed, and then fructus forsythiae essential oil, chamomile essential oil, chastetree fruit essential oil, rhizoma acori graminei essential oil, lavender essential oil, fructus cnidii essential oil, mint essential oil and optional auxiliary agents are sequentially added and uniformly mixed.
The invention also aims to provide the application of the acne-removing essential oil composition in preparing skin care products.
According to the acne-removing essential oil composition, on the basis of the combination of the traditional Chinese medicine compatibility theory and the essential oil blending technology, by means of the mutual synergistic matching of the fructus forsythiae essential oil, the chaste tree oil, the fructus cnidii essential oil, the rhizoma acori graminei essential oil, the mint essential oil, the lavender essential oil, the chamomile essential oil, the sweet almond oil, the vitamin E, the wheat germ oil and the jojoba oil, the acne-removing essential oil composition can be used for adjusting sebum secretion balance, resisting inflammation, sterilizing and activating cell self-repair, can be used for fading acne marks and soothing skin, is safe and efficient, does not have toxic or side effect, and.
The preparation method of the acne-removing essential oil composition provided by the invention is simple in process, convenient to operate, suitable for industrial mass production and capable of effectively improving the production efficiency.
Detailed Description
Embodiments of the present invention will be described in detail below with reference to examples, but it will be understood by those skilled in the art that the following examples are only illustrative of the present invention and should not be construed as limiting the scope of the present invention. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.
According to one aspect of the invention, the invention provides an acne-removing essential oil composition which comprises the following components in parts by weight: 1-5 parts of fructus forsythiae essential oil, 0.1-1 part of schizonepeta essential oil, 0.1-1 part of fructus cnidii essential oil, 0.1-1 part of rhizoma acori graminei essential oil, 0.05-0.5 part of mint essential oil, 0.1-1 part of lavender essential oil, 0.5-2 parts of chamomile essential oil, 20-30 parts of sweet almond oil, 10-20 parts of vitamin E, 20-30 parts of wheat germ oil and 10-20 parts of jojoba oil, wherein the sum of the components is 100 parts.
Typical but not limiting parts by mass of forsythia essential oil in the present invention are, for example, 1, 1.2, 1.5, 1.8, 2, 2.2, 2.5, 2.8, 3, 3.2, 3.5, 3.8, 4, 4.2, 4.5, 4.8 or 5 parts. The fructus forsythiae essential oil has effects of clearing heat and detoxicating, cooling blood and removing speckle, and resisting oxidation.
Typical but not limiting parts by mass of catmint essential oil are, for example, 0.1, 0.15, 0.2, 0.25, 0.3, 0.35, 0.4, 0.45, 0.5, 0.55, 0.6, 0.65, 0.7, 0.75, 0.8, 0.85, 0.9, 0.95 or 1 part. The schizonepeta essential oil has the effects of relieving fever, easing pain and resisting inflammation.
Typical but not limiting parts by mass of the cnidium fruit essential oil are, for example, 0.1, 0.15, 0.2, 0.25, 0.3, 0.35, 0.4, 0.45, 0.5, 0.55, 0.6, 0.65, 0.7, 0.75, 0.8, 0.85, 0.9, 0.95 or 1 part. Fructus Cnidii essential oil has effects of eliminating dampness and relieving itching.
Typical but not limiting parts by mass of the grassleaved sweetflag essential oil are, for example, 0.1, 0.15, 0.2, 0.25, 0.3, 0.35, 0.4, 0.45, 0.5, 0.55, 0.6, 0.65, 0.7, 0.75, 0.8, 0.85, 0.9, 0.95 or 1 part. The rhizoma Acori Graminei essential oil has effects of eliminating dampness, tranquilizing mind, relieving swelling and pain.
Typical but not limiting mass parts of the mint essential oil are, for example, 0.05, 0.08, 0.1, 0.12, 0.15, 0.18, 0.2, 0.22, 0.25, 0.28, 0.3, 0.32, 0.35, 0.38, 0.4, 0.42, 0.45, 0.48 or 0.5 parts. The herba Menthae essential oil has effects of resisting allergy, promoting eruption, killing bacteria and relieving pain.
Typical but not limiting parts by mass of the lavender essential oil are e.g. 0.1, 0.15, 0.2, 0.25, 0.3, 0.35, 0.4, 0.45, 0.5, 0.55, 0.6, 0.65, 0.7, 0.75, 0.8, 0.85, 0.9, 0.95 or 1 part. The lavender essential oil has the effects of sterilizing, disinfecting, tranquilizing and detoxifying, and also has the effects of accelerating cell regeneration, promoting rehabilitation and preventing scars.
Typical but not limiting parts by mass of the chamomile essential oil are, for example, 0.5, 0.55, 0.6, 0.65, 0.7, 0.75, 0.8, 0.85, 0.9, 0.95, 1, 1.05, 1.1, 1.15, 1.2, 1.25, 1.3, 1.35, 1.4, 1.45, 1.5, 1.55, 1.6, 1.65, 1.7, 1.75, 1.8, 1.85, 1.9, 1.95 or 2 parts. The chamomile essential oil has the effects of promoting sleep, diminishing inflammation and relieving itching.
Typical but not limiting parts by mass of vitamin E are e.g. 10, 10.5, 11, 11.5, 12, 12.5, 13, 13.5, 14, 14.5, 15, 15.5, 16, 16.5, 17, 17.5, 18, 18.5, 19, 19.5 or 20 parts. Vitamin E has strong oxidation effect, and can help skin resist damage of free radicals, ultraviolet rays and pollutants, and keep skin elasticity.
Typical but not limiting parts by mass of sweet almond oil are for example 20, 20.5, 21, 21.5, 22, 22.5, 23, 23.5, 24, 24.5, 25, 25.5, 26, 26.5, 27, 27.5, 28, 28.5, 29, 29.5 or 30 parts. Sweet almond oil has the effects of lubrication, refreshing, skin-friendly, itching relieving, dryness removing and inflammation diminishing.
Typical but not limiting parts by mass of wheat germ oil are for example 20, 20.5, 21, 21.5, 22, 22.5, 23, 23.5, 24, 24.5, 25, 25.5, 26, 26.5, 27, 27.5, 28, 28.5, 29, 29.5 or 30 parts. The wheat germ oil has effects of regulating oil secretion, resisting oxidation and caring skin.
Typical but not limiting parts by mass of jojoba oil are for example 10, 10.5, 11, 11.5, 12, 12.5, 13, 13.5, 14, 14.5, 15, 15.5, 16, 16.5, 17, 17.5, 18, 18.5, 19, 19.5, 20, 20.5, 21, 21.5, 22, 22.5, 23, 23.5, 24, 24.5 or 25 parts. Jojoba oil has strong permeability, and can moisten, moisturize and care skin.
In the invention, the essential oil is the essence of the vegetation, and 99.9 percent of the essential oil ensures the original efficacy of the plants. The acne-removing essential oil composition provided by the invention is compounded by multiple essential oils, is combined with multiple basic oils by the aid of vitamin E, fully utilizes the advantages of small molecular weight and high permeability of the essential oils, quickly permeates into skin and blood, reaches a cuticle layer within 3 seconds, reaches a corium layer within 6 seconds, enters subcutaneous tissues within 3 minutes, reaches blood for 6 minutes to perform systemic blood circulation, has the efficacy of medicine directly reaching a focus, quickly relieves symptoms, is free of chemical additives, is natural, green, pure, healthy, safe and efficient, has no toxic or side effect, and causes zero pollution to skin.
According to the acne-removing essential oil composition, on the basis of the combination of the traditional Chinese medicine compatibility theory and the essential oil blending technology, by means of the mutual synergistic matching of the fructus forsythiae essential oil, the chaste tree oil, the fructus cnidii essential oil, the rhizoma acori graminei essential oil, the mint essential oil, the lavender essential oil, the chamomile essential oil, the sweet almond oil, the vitamin E, the wheat germ oil and the jojoba oil, the acne-removing essential oil composition can be used for adjusting sebum secretion balance, resisting inflammation, sterilizing and activating cell self-repair, can be used for fading acne marks and soothing skin, is safe and efficient, does not have toxic or side effect, and.
The compositions of the present invention also include a variety of optional ingredients that are more aesthetically acceptable or provide additional use benefits to the compositions. A variety of such ingredients are well known to those skilled in the art. They include, but are not limited to, fatty alcohols, sodium chloride, ethanol, pH adjusters, colorants, suspending agents, sunscreens, thickeners, viscosity modifiers, and the like.
In a preferred embodiment of the invention, the acne-removing essential oil composition further comprises 0.2-1 part of an auxiliary agent.
Typical but not limiting mass parts of auxiliaries in the context of the invention are, for example, 0.2, 0.25, 0.3, 0.35, 0.4, 0.45, 0.5, 0.55, 0.6, 0.65, 0.7, 0.75, 0.8, 0.85, 0.9, 0.95 or 1 part.
In a further preferred embodiment of the invention, the adjuvant comprises at least one of a gelling agent, a humectant or a preservative.
[ gelling agent ]
In a preferred embodiment of the present invention, the gelling agent is a water-soluble polymer, including but not limited to natural polymers, modified natural polymers and synthetic polymers.
The water-soluble high molecular substance is preferably cellulose and its derivatives, such as methylcellulose, hydroxypropyl methylcellulose phthalate, hydroxypropyl methylcellulose succinate, hydroxymethyl ethylcellulose, carboxymethyl ethylcellulose, sodium carboxymethyl cellulose, hydroxyethyl cellulose, cellulose acetate phthalate.
Synthetic macromolecules include, but are not limited to, polyethylene glycol, polyvinyl alcohol, polyvinyl pyrrolidone, polyvinyl acetal diethylamino complex acid ester, aminoalkyl methacrylate copolymer-E, aminoalkyl methacrylate copolymer-RS, methacrylic acid copolymer-L, methacrylic acid copolymer-LD, methacrylic acid copolymer-S, carboxyvinyl polymer, and the like.
Natural polymers and sugars include, but are not limited to, acacia, sodium alginate, propylene glycol alginate, agar, gelatin, xanthan gum, and the like.
In a further preferred embodiment of the present invention, the gelling agent is selected from one or more of methylcellulose, hydroxypropyl cellulose, polyethylene glycol or polyvinyl alcohol.
[ humectant ]
In a preferred embodiment of the invention, the moisturizing agent is selected from polyol materials.
Polyols include, but are not limited to, diols and polyether alcohols.
The diol is selected from one or more of dipropylene glycol, ethylene glycol, propylene glycol, hexylene glycol, isoprene glycol, butylene glycol, pentanediol, butane diol, 1, 2-propane diol, pentane diol, decane diol and dodecane diol.
In a preferred embodiment of the present invention, the polyether alcohol has a number average molecular weight of 150-600, such as polyethylene glycol 300 and polyglycerol 500.
[ preservatives ]
In a preferred embodiment of the present invention, preservatives include, but are not limited to, phenoxyethanol and/or ethylhexyl glycerin.
According to a second aspect of the invention, the invention provides a preparation method of the acne-removing essential oil composition, which comprises the following steps:
mixing fructus forsythiae essential oil, herba Schizonepetae essential oil, fructus Cnidii essential oil, rhizoma Acori Graminei essential oil, herba Menthae essential oil, Lavender essential oil, flos Matricariae Chamomillae essential oil, sweet almond oil, vitamin E, wheat germ oil, jojoba oil and optional adjuvants uniformly to obtain the acne removing essential oil composition.
The preparation method of the acne-removing essential oil composition provided by the invention is simple in process, convenient to operate, suitable for industrial mass production and capable of effectively improving the production efficiency.
In a preferred embodiment of the invention, sweet almond oil, vitamin E, wheat germ oil and jojoba oil are mixed uniformly, and then fructus forsythiae essential oil, chamomile essential oil, vitex essential oil, rhizoma acori graminei essential oil, lavender essential oil, fructus cnidii essential oil, mint essential oil and optional auxiliary agents are added in sequence and mixed uniformly.
The acne removing essential oil composition provided by the invention is sequentially added into a container from large to small according to the proportion of each component, and after sealing, the container is forcibly rolled to uniformly mix all the components, so that the acne removing essential oil composition is prepared.
The application method of the acne-removing essential oil composition provided by the invention comprises the following steps: the acne removing essential oil composition is applied to cleaned acne parts, and is absorbed by massaging once a day, morning and evening.
The acne-removing essential oil composition provided by the invention is simple in use method, convenient to use and wide in application prospect.
The invention also aims to provide application of the acne-removing essential oil composition in preparation of skin care products.
In the present invention, skin care products include, but are not limited to, creams, masks, lotions, and the like.
The technical solution provided by the present invention is further described below with reference to examples and comparative examples.
Example 1
The embodiment provides an acne-removing essential oil composition which comprises the following components in parts by mass: 1 part of fructus forsythiae essential oil, 1 part of schizonepeta essential oil, 0.1 part of fructus cnidii essential oil, 1 part of rhizoma acori graminei essential oil, 0.05 part of mint essential oil, 1 part of lavender essential oil, 0.5 part of chamomile essential oil, 20 parts of sweet almond oil, 20 parts of vitamin E, 30 parts of wheat germ oil and 15.45 parts of jojoba oil.
Example 2
The embodiment provides an acne-removing essential oil composition which comprises the following components in parts by mass: 5 parts of fructus forsythiae essential oil, 0.1 part of schizonepeta essential oil, 1 part of fructus cnidii essential oil, 0.1 part of rhizoma acori graminei essential oil, 0.5 part of mint essential oil, 0.1 part of lavender essential oil, 2 parts of chamomile essential oil, 30 parts of sweet almond oil, 10 parts of vitamin E, 20 parts of wheat germ oil and 21.2 parts of jojoba oil.
Example 3
The embodiment provides an acne-removing essential oil composition which comprises the following components in parts by mass: 2 parts of fructus forsythiae essential oil, 1 part of schizonepeta essential oil, 0.2 part of fructus cnidii essential oil, 0.8 part of rhizoma acori graminei essential oil, 0.05 part of mint essential oil, 0.8 part of lavender essential oil, 1 part of chamomile essential oil, 24 parts of sweet almond oil, 16 parts of vitamin E, 24.15 parts of wheat germ oil and 20 parts of jojoba oil.
Example 4
The embodiment provides an acne-removing essential oil composition which comprises the following components in parts by mass: 4 parts of fructus forsythiae essential oil, 0.4 part of schizonepeta essential oil, 0.7 part of fructus cnidii essential oil, 0.2 part of rhizoma acori graminei essential oil, 0.45 part of mint essential oil, 0.15 part of lavender essential oil, 1 part of chamomile essential oil, 28.1 parts of sweet almond oil, 15 parts of vitamin E, 25 parts of wheat germ oil and 25 parts of jojoba oil.
Example 5
The embodiment provides an acne-removing essential oil composition which comprises the following components in parts by mass: 3 parts of fructus forsythiae essential oil, 0.8 part of schizonepeta essential oil, 0.4 part of fructus cnidii essential oil, 0.7 part of rhizoma acori graminei essential oil, 0.2 part of mint essential oil, 0.7 part of lavender essential oil, 1 part of chamomile essential oil, 25 parts of sweet almond oil, 20 parts of vitamin E, 26.2 parts of wheat germ oil and 22 parts of jojoba oil.
Example 6
The embodiment provides an acne-removing essential oil composition which comprises the following components in parts by mass: 4 parts of fructus forsythiae essential oil, 0.5 part of schizonepeta essential oil, 0.6 part of fructus cnidii essential oil, 0.3 part of rhizoma acori graminei essential oil, 0.4 part of mint essential oil, 0.3 part of lavender essential oil, 1 part of chamomile essential oil, 30 parts of sweet almond oil, 15 parts of vitamin E, 20 parts of wheat germ oil and 17.9 parts of jojoba oil.
Example 7
The embodiment provides an acne-removing essential oil composition which comprises the following components in parts by mass: 3.5 parts of fructus forsythiae essential oil, 0.6 part of schizonepeta essential oil, 0.5 part of fructus cnidii essential oil, 0.5 part of rhizoma acori graminei essential oil, 0.3 part of mint essential oil, 0.5 part of lavender essential oil, 1.5 parts of chamomile essential oil, 27.6 parts of sweet almond oil, 18 parts of vitamin E, 25 parts of wheat germ oil and 22 parts of jojoba oil.
Example 8
The present example provides a method for preparing an anti-acne essential oil composition, and the anti-acne essential oil compositions provided in examples 1 to 7 are prepared according to the following steps:
the sweet almond oil, the vitamin E, the wheat germ oil and the jojoba oil are put into a closed container and mixed uniformly, then the forsythia essential oil, the chamomile essential oil, the schizonepeta essential oil, the acorus gramineus essential oil, the lavender essential oil, the cnidium fruit essential oil, the mint essential oil and optional auxiliary agents are added in sequence, and the mixture is rolled by force to mix the components uniformly, so that the acne-removing essential oil composition is prepared.
Comparative example 1
The comparison example provides an acne-removing essential oil composition, and the difference between the comparison example and the example 7 lies in that 0.1 part of fructus forsythiae essential oil, 3 parts of herba schizonepetae essential oil, 2 parts of fructus cnidii essential oil, 3 parts of rhizoma acori graminei essential oil, 1 part of mint essential oil, 3 parts of lavender essential oil, 0.1 part of chamomile essential oil, 40 parts of sweet almond oil, 2 parts of vitamin E, 40 parts of wheat germ oil and 5.8 parts of jojoba oil.
Comparative example 2
The comparison example provides an acne-removing essential oil composition, and the difference between the comparison example and the comparison example 7 is that 10 parts of fructus forsythiae essential oil, 0.05 part of herba schizonepetae essential oil, 0.05 part of fructus cnidii essential oil, 0.05 part of rhizoma acori graminei essential oil, 0.01 part of mint essential oil, 0.04 part of lavender essential oil, 5 parts of chamomile essential oil, 15 parts of sweet almond oil, 30 parts of vitamin E, 9.8 parts of wheat germ oil and 30 parts of jojoba oil.
Comparative example 3
The comparative example provides an acne removing essential oil composition, and is different from example 7 in that fructus forsythiae essential oil is not added.
Comparative example 4
The comparative example provides an acne removing essential oil composition, and is different from example 7 in that chamomile essential oil is not added.
Comparative example 5
The comparative example provides an acne removing essential oil composition, which differs from example 7 in that vitamin E is not added.
Comparative example 6
The comparative example provides an acne removing essential oil composition, which differs from example 7 in that no catmint essential oil is added.
Comparative example 7
The comparative example provides an acne removing essential oil composition, and is different from example 7 in that fructus cnidii essential oil is not added.
Comparative example 8
The comparative example provides an acne-removing essential oil composition, and is different from example 7 in that no acorus gramineus soland essential oil is added.
Comparative example 9
The comparative example provides an acne removing essential oil composition, which differs from example 7 in that peppermint essential oil is not added.
Comparative example 10
The comparative example provides an acne removing essential oil composition, and is different from example 7 in that lavender essential oil is not added.
Comparative example 11
The comparative example provides an acne removing essential oil composition, which differs from example 7 in that sweet almond oil is not added.
Comparative example 12
The comparative example provides an acne removing essential oil composition, which differs from example 7 in that wheat germ oil is not added.
Comparative example 13
The comparative example provides an acne removing essential oil composition, which differs from example 7 in that jojoba oil is not added.
Comparative example 14
The comparative example provides an acne-removing essential oil composition, and is different from example 7 in that 7.4 parts of fructus forsythiae essential oil is not added with schizonepeta essential oil, fructus cnidii essential oil, rhizoma acori graminei essential oil, mint essential oil, lavender essential oil and chamomile essential oil.
Comparative example 15
The comparative example provides an acne-removing essential oil composition, and is different from example 7 in that 7.4 parts of schizonepeta essential oil are added, and forsythia essential oil, cnidium essential oil, acorus gramineus essential oil, mint essential oil, lavender essential oil and chamomile essential oil are not added.
Comparative example 16
The comparative example provides an acne-removing essential oil composition, and is different from example 7 in that 7.4 parts of fructus cnidii essential oil are not added with fructus forsythiae essential oil, herba schizonepetae essential oil, rhizoma acori graminei essential oil, mint essential oil, lavender essential oil and chamomile essential oil.
Comparative example 17
The comparative example provides an acne-removing essential oil composition, and is different from example 7 in that 7.4 parts of rhizoma acori graminei essential oil are not added with fructus forsythiae essential oil, fructus cnidii essential oil, herba schizonepetae essential oil, mint essential oil, lavender essential oil and chamomile essential oil.
Comparative example 18
The comparative example provides an acne-removing essential oil composition, and is different from example 7 in that 7.4 parts of mint essential oil are not added with fructus forsythiae essential oil, fructus cnidii essential oil, herba schizonepetae essential oil, rhizoma acori graminei essential oil, lavender essential oil and chamomile essential oil.
Comparative example 19
The comparative example provides an acne-removing essential oil composition, and is different from example 7 in that 7.4 parts of lavender essential oil are not added with fructus forsythiae essential oil, fructus cnidii essential oil, herba schizonepetae essential oil, rhizoma acori graminei essential oil, mint essential oil and chamomile essential oil.
Comparative example 20
The comparative example provides an acne-removing essential oil composition, and is different from example 7 in that 7.4 parts of chamomile essential oil is added, and fructus forsythiae essential oil, fructus cnidii essential oil, herba schizonepetae essential oil, rhizoma acori graminei essential oil, mint essential oil and lavender essential oil are not added.
Comparative example 21
The comparative example provides an anti-acne gel, which is a commercially available clindamycin phosphate gel.
Comparative example 22
This comparative example provides a PBS solution.
The preparation methods of the acne-removing essential oil compositions provided in the comparative examples 1 to 20 are the same as those of the acne-removing essential oil composition provided in example 7, and are not repeated herein.
Test example 1
In order to verify the bacteriostatic effect of the acne removing essential oil composition provided by the invention, in-vitro bacteriostatic activity tests of acne pathogenic bacteria are respectively carried out on the acne removing essential oil composition provided by examples 1-7, the acne removing essential oil composition provided by comparative examples 1-20, and the acne removing gel and solution provided by comparative examples 21-22.
1.1 strains
A propionibacterium acnes standard strain, a staphylococcus aureus standard strain and an escherichia coli standard strain.
1.2 test method one
Firstly, the three strains are respectively prepared into 10 by using 0.03mol/L PBS solution5Bacterial suspensions of cfu/ml were kept ready, and then the anti-acne essential oil compositions provided in examples 1 to 7 and comparative examples 1 to 20, the anti-acne gel provided in comparative example 21 and the PBS solution provided in comparative example 22 were subjected to evaluation of the inhibition rate of acne pathogenic bacteria according to the suspension quantification method specified in QB/T2738-2012, and the results are shown in table 1:
TABLE 1 data sheet for the bacteriostatic rate of acne pathogens
As can be seen from table 1, when the acne-removing essential oil composition provided in examples 1 to 7 is reacted with a corresponding bacterial suspension for 10min, the bacteriostatic rate of staphylococcus aureus is higher than 80%, the bacteriostatic rate of propionibacterium acnes is higher than 75%, and the bacteriostatic rate of escherichia coli is higher than 95%, which indicates that the acne-removing essential oil composition provided by the invention can significantly inhibit the growth of acne pathogenic bacteria, regulate sebum secretion balance, and effectively relieve the pain of patients.
As can be seen by comparing examples 1-7 with comparative example 22, the acne-removing essential oil composition provided by the invention has a remarkable inhibiting effect on staphylococcus aureus, propionibacterium acnes and escherichia coli.
As can be seen by comparing examples 1-7 with comparative example 21, the anti-acne essential oil composition provided by the invention has slightly higher inhibitory effect on Staphylococcus aureus, Propionibacterium acnes and Escherichia coli than clindamycin phosphate gel, is prepared by blending natural green essential oil and base oil, has no toxic or side effect, and is healthier, safer and more environment-friendly.
As can be seen from comparison between examples 1 to 7 and comparative examples 1 to 20, the acne-removing essential oil composition provided by the invention has a more significant inhibiting effect on staphylococcus aureus, propionibacterium acnes and escherichia coli and can effectively relieve pain of patients by synergistic cooperation of specific parts by mass of fructus forsythiae essential oil, vitex negundo essential oil, fructus cnidii essential oil, rhizoma acori graminei essential oil, mint essential oil, lavender essential oil, chamomile essential oil, sweet almond oil, vitamin E, wheat germ oil and jojoba oil on the basis of combination of traditional Chinese medicine compatibility and essential oil blending.
1.3 test method two
The three strains were prepared to 10 according to the method of 1.25cfu/ml bacterial suspension, then the acne pathogenic bacteria inhibiting ring diameter determination is carried out on the acne removing essential oil composition provided by examples 1-7 and comparative examples 1-20, the acne removing gel provided by comparative example 21 and the PBS solution provided by comparative example 22 according to the inhibiting ring evaluation method specified by QB/T2738-2012, and the results are shown in Table 2:
TABLE 2 data table of diameter of bacteriostatic ring of acne pathogenic bacteria
As can be seen from table 2, the diameter of the inhibition ring of the acne-removing essential oil composition provided in examples 1 to 7 to staphylococcus aureus is greater than 22mm, the diameter of the inhibition ring of propionibacterium acnes is greater than 24mm, and the diameter of the inhibition ring of propionibacterium acnes is greater than 34mm, which indicates that the acne-removing essential oil composition provided by the present invention can significantly inhibit the growth of acne pathogenic bacteria, regulate sebum secretion balance, and effectively alleviate the pain of patients.
As can be seen by comparing examples 1-7 with comparative example 22, the acne-removing essential oil composition provided by the invention has a remarkable inhibiting effect on staphylococcus aureus, propionibacterium acnes and escherichia coli.
As can be seen by comparing examples 1-7 with comparative example 21, the diameter of the bacteriostatic ring of the acne-removing essential oil composition provided by the invention on staphylococcus aureus, propionibacterium acnes and escherichia coli is slightly larger than that of clindamycin phosphate gel, and the acne-removing essential oil composition is prepared by blending natural green essential oil and base oil, has no toxic or side effect, is healthier, safer, more environment-friendly and has better inhibiting effect on acne pathogenic bacteria.
As can be seen from comparison between examples 1 to 7 and comparative examples 1 to 20, the acne-removing essential oil composition provided by the invention has a more significant inhibiting effect on staphylococcus aureus, propionibacterium acnes and escherichia coli and can effectively relieve pain of patients by synergistic cooperation of specific parts by mass of fructus forsythiae essential oil, vitex negundo essential oil, fructus cnidii essential oil, rhizoma acori graminei essential oil, mint essential oil, lavender essential oil, chamomile essential oil, sweet almond oil, vitamin E, wheat germ oil and jojoba oil on the basis of combination of traditional Chinese medicine compatibility and essential oil blending.
Test example 2
In order to test the actual use effect of the acne removing materials provided by the examples 1-7 and the comparative examples 1-22, 2900 patients with facial conventional acne are screened according to the diagnosis standard and treatment principle of cosmetic contact dermatitis for population trial investigation, 2900 applicable populations are divided into 29 groups, 100 people in each group use the acne removing essential oil composition provided by the examples 1-7, 1-7 groups use the acne removing essential oil composition provided by the comparative examples 1-20 groups, 8-29 groups use the acne removing essential oil composition provided by the comparative example 1-20 groups, the acne removing gel provided by the comparative example 21 and the PBS solution provided by the comparative example 22, and the use method is as follows: after cleaning the face of an acne patient every day, applying an anti-acne substance to the affected part to treat the acne, applying the anti-acne substance once in the morning and at night, trying for four weeks, filling a survey paper, and finally counting the result. The acne removing effect of the acne removing compound essential oil is detected, and the result is shown in table 3:
TABLE 3 evaluation chart of the use effect of acne patients
Note: the obvious effect standard is that most of acne disappears and no new acne appears; the effective standard is that the acne is partially hours and the symptom is relieved, and new acne occasionally appears; the criteria for failure were no apparent changes in the acne appearance.
As can be seen from the comparison between the group 1 and the group 29 in the table 3, the acne-removing essential oil composition provided by the invention can quickly permeate into the skin, inhibit the growth of acne pathogenic bacteria, and regulate the sebum secretion balance, and the effective rate reaches 100% after four weeks.
As can be seen by comparing the groups 1-7 with the group 28, the acne-removing essential oil composition provided by the invention has a slightly higher effect speed on acne than clindamycin phosphate gel, and the treatment effect is slightly better than that of the clindamycin phosphate gel.
As can be seen by comparing 1-7 groups with 8-27 groups, the acne-removing essential oil composition provided by the invention has the advantages that on the basis of the combination of traditional Chinese medicine compatibility and essential oil blending, the acne-removing essential oil composition has a faster effect on acne and a better treatment effect through the synergistic cooperation of specific mass parts of fructus forsythiae essential oil, vitex essential oil, fructus cnidii essential oil, rhizoma acori graminei essential oil, mint essential oil, lavender essential oil, chamomile essential oil, sweet almond oil, vitamin E, wheat germ oil and jojoba oil.
In addition, the investigation also carries out investigation on the facial irritation, and the investigation result shows that 1-27 groups of people have no irritation record, 10 groups of 28 groups of people consider that the people have obvious irritation and 30 groups of people consider that the people have slight irritation, which shows that the acne removing essential oil composition provided by the invention is natural and green, safe and efficient, has no toxic or side effect, and cannot influence the health of human bodies.
Finally, it should be noted that: the above embodiments are only used to illustrate the technical solution of the present invention, and not to limit the same; while the invention has been described in detail and with reference to the foregoing embodiments, it will be understood by those skilled in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some or all of the technical features may be equivalently replaced; and the modifications or the substitutions do not make the essence of the corresponding technical solutions depart from the scope of the technical solutions of the embodiments of the present invention.
Claims (11)
1. The acne-removing essential oil composition is characterized by comprising the following components in parts by mass: 1-5 parts of fructus forsythiae essential oil, 0.1-1 part of schizonepeta essential oil, 0.1-1 part of fructus cnidii essential oil, 0.1-1 part of rhizoma acori graminei essential oil, 0.05-0.5 part of mint essential oil, 0.1-1 part of lavender essential oil, 0.5-2 parts of chamomile essential oil, 20-30 parts of sweet almond oil, 78-20 parts of vitamin E10, 20-30 parts of wheat germ oil and 10-25 parts of jojoba oil, wherein the sum of the components is 100 parts.
2. The acne removing essential oil composition according to claim 1, which is characterized by comprising the following components in parts by mass: 2-4 parts of fructus forsythiae essential oil, 0.4-1 part of schizonepeta essential oil, 0.2-0.7 part of fructus cnidii essential oil, 0.2-0.8 part of rhizoma acori graminei essential oil, 0.05-0.45 part of mint essential oil, 0.15-0.8 part of lavender essential oil, 1-2 parts of chamomile essential oil, 20-30 parts of sweet almond oil, 10-20 parts of vitamin E, 20-30 parts of wheat germ oil and 10-25 parts of jojoba oil, wherein the sum of the components is 100 parts.
3. The acne removing essential oil composition according to claim 1, which is characterized by comprising the following components in parts by mass: 3-4 parts of fructus forsythiae essential oil, 0.5-0.8 part of schizonepeta essential oil, 0.4-0.6 part of fructus cnidii essential oil, 0.3-0.7 part of rhizoma acori graminei essential oil, 0.2-0.4 part of mint essential oil, 0.3-0.7 part of lavender essential oil, 1-2 parts of chamomile essential oil, 20-30 parts of sweet almond oil, 10-20 parts of vitamin E, 20-30 parts of wheat germ oil and 10-25 parts of jojoba oil, wherein the sum of the components is 100 parts.
4. The acne-removing essential oil composition according to any one of claims 1 to 3, further comprising 0.2 to 1 part by mass of an auxiliary agent.
5. The anti-acne essential oil composition according to claim 4, wherein the auxiliary agent comprises at least one of a gelling agent, a humectant or a preservative.
6. The acne removing essential oil composition according to claim 5, wherein the gelling agent is selected from at least one of methylcellulose, hydroxypropyl cellulose, polyethylene glycol or polyvinyl alcohol.
7. The anti-acne essential oil composition according to claim 5, wherein the humectant is selected from at least one of dipropylene glycol, ethylene glycol, hexylene glycol, isoprene glycol, butylene glycol, or pentylene glycol.
8. The acne removing essential oil composition according to claim 5, wherein the preservative is phenoxyethanol and/or ethylhexyl glycerin.
9. The preparation method of the acne removing essential oil composition according to any one of claims 1 to 8, which is characterized by comprising the following steps:
mixing fructus forsythiae essential oil, herba Schizonepetae essential oil, fructus Cnidii essential oil, rhizoma Acori Graminei essential oil, herba Menthae essential oil, Lavender essential oil, flos Matricariae Chamomillae essential oil, sweet almond oil, vitamin E, wheat germ oil, jojoba oil and optional adjuvants uniformly to obtain the acne removing essential oil composition.
10. The preparation method of the acne-removing essential oil composition according to claim 9, wherein the sweet almond oil, the vitamin E, the wheat germ oil and the jojoba oil are mixed uniformly, and then the forsythia essential oil, the chamomile essential oil, the schizonepeta essential oil, the grassleaf sweelflag rhizome essential oil, the lavender essential oil, the common cnidium fruit essential oil, the mint essential oil and optional auxiliary agents are sequentially added and mixed uniformly.
11. Use of the anti-acne essential oil composition according to any one of claims 1 to 8 in the preparation of a skin care product.
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|---|---|---|---|---|
| CN1742752A (en) * | 2005-10-08 | 2006-03-08 | 晏四平 | Atomizing agent containing medicinal plant oil |
| CN105112180A (en) * | 2015-09-09 | 2015-12-02 | 中国科学院植物研究所 | Natural plant flower fragrance type essential oil soap having bacteriostatic function and producing method thereof |
| CN105832568A (en) * | 2016-03-26 | 2016-08-10 | 佛山市芊茹化妆品有限公司 | Solid micro-emulsion, preparation method and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1742752A (en) * | 2005-10-08 | 2006-03-08 | 晏四平 | Atomizing agent containing medicinal plant oil |
| CN105112180A (en) * | 2015-09-09 | 2015-12-02 | 中国科学院植物研究所 | Natural plant flower fragrance type essential oil soap having bacteriostatic function and producing method thereof |
| CN105112180B (en) * | 2015-09-09 | 2017-12-01 | 中国科学院植物研究所 | Natural plants floral type essential oil soap with bacteria resistance function and preparation method thereof |
| CN105832568A (en) * | 2016-03-26 | 2016-08-10 | 佛山市芊茹化妆品有限公司 | Solid micro-emulsion, preparation method and application thereof |
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