CN109330947A - A kind of oil control and acne removal toner and preparation method thereof - Google Patents
A kind of oil control and acne removal toner and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of oil control and acne removal toners and preparation method thereof.The toner includes following components: 1,3 butylene glycol, dipropylene glycol, allantoin, amino acid derivativges, water-soluble fullerene, plant extracts, EDTA- disodium, sodium carboxymethylcellulose, glycine betaine, preservative and deionized water.The present invention being capable of effectively Sage Extract, skin is helped to continue oil-control, inhibiting bacteria and diminishing inflammation maintains the normal ecosystem of skin, unimpeded pore, blowdown promotes blood circulation except poison, and cutin is promoted to fall off and inhibit melanin production, various aspects play anti-acne in all directions, the effect of smoothing acne scar, eliminating acne print is very suitable to oiliness, the consumer of whelk uses.
Description
Technical field
The invention belongs to cosmetic technical fields, and in particular to a kind of oil control and acne removal toner and preparation method thereof.
Background technique
Whelk is a kind of occurs in pilosebaceous follicle and its inflammatory disorders of surrounding tissue.Research confirmation, whelk
Occur mainly with the close phase of factors such as hypersteatosis, pilosebaceous duct obstruction, bacterium infection and inflammatory reaction
It closes.Wherein, grease and sebum blocking pore are the basic reasons for inducing whelk, and bacterium infection then aggravates the concurrent of whelk
Symptom.
Although there are many oil control and acne removal class cosmetics in the market, most products are added to chemical bactericide, hormone, astringent
With anti-inflammatory agent etc., though it can sterilize in a short time or anti-inflammatory, it is big to skin irritation, it is used for a long time and will increase the negative of skin
Load, and cause the allergic symptoms such as red swelling of the skin, suppuration or pain, and since pathogen easily generates drug resistance, acne is quickly
It will recur, and form scar or pigmentation.Antibiotic and hormonal substance are big since side effect is used for a long time, banned
With.In addition, some Chinese medicine acne-eliminating cosmetics are due to the mechanism of action and ingredient collocation is indefinite that product is caused to work slow, treatment cycle
Length has niff and color more, can also leave black or Red Sigil after healing, also not by the welcome of consumer.Therefore,
The oil control and acne removal product without rebound has very big market prospects after developing that a kind of pair of skin is non-stimulated, effect is obvious and deactivating.
Summary of the invention
The object of the present invention is to provide a kind of oil control and acne removal toners and preparation method thereof.The toner is respectively at split-phase
Mutually coordinate, from many aspects, comprehensive effect play splendid oil-control, inhibiting bacteria and diminishing inflammation, anti-acne skin effect.
The present invention is achieved by the following technical programs:
A kind of oil control and acne removal toner, including following components and its parts by weight: 1~3 part of 1,3-BDO, dipropylene glycol
2~5 parts, 1~3 part of allantoin, 0.5~2.5 part of amino acid derivativges, 0.5~1.5 part of water-soluble fullerene, plant extracts 5
~8 parts, 0.02~0.05 part of EDTA- disodium, 0.5~1 part of sodium carboxymethylcellulose, 0.5~2 part of glycine betaine, preservative 0.1~
0.3 part and 60~80 parts of deionized water.
It is preferred that the oil control and acne removal toner, including following components and its parts by weight: 2 parts of 1,3-BDO, double third
4 parts of glycol, 2 parts of allantoin, 2 parts of amino acid derivativges, 1 part of water-soluble fullerene, 7 parts of plant extracts, EDTA- disodium 0.05
Part, 0.8 part of sodium carboxymethylcellulose, 1.5 parts of glycine betaine, 0.2 part of preservative and 80 parts of deionized water.
The plant extracts is oriental wormwood parthenium extract, Flos Sophorae extract and mulberry root extract with (2~4): (1.5~
3): the mass ratio composition of (1~2).
It is preferred that the plant extracts is oriental wormwood parthenium extract, Flos Sophorae extract and mulberry root extract with the matter of 3:2:2
Amount is than composition.
The amino acid derivativges are decoyl glycine, palmityl glycine, endecatylene acyl glycine with 1:(0.5
~1): the mass ratio composition of (0.1~0.5).
It is preferred that the amino acid derivativges are decoyl glycine, palmityl glycine, endecatylene acyl glycine with 1:
1:0.5 mass ratio composition.
It is sweet that the preservative is selected from ethoxy urea, Phenoxyethanol, Sensiva SC50, methylisothiazolinone, chlorobenzene
One or more of ether, methyl hydroxybenzoate or ethyl hydroxy benzoate.
Oil control and acne removal toner of the invention is to be prepared by the following method to obtain, method includes the following steps: will match
1,3 butylene glycol, dipropylene glycol, allantoin, amino acid derivativges, sodium carboxymethylcellulose, glycine betaine and the deionized water just measured
Mixing is heated to 70 DEG C, and stirring makes it completely dissolved, and cools down 40 DEG C, and water-soluble fullerene, plant extracts, EDTA- is added
Disodium and preservative are uniformly mixed, discharge to obtain the final product.
Oil control and acne removal toner of the invention is mentioned with amino acid derivativges, water-soluble fullerene, oriental wormwood parthenium extract, sophora flower
Take object and mulberry root extract as main functional component, from multi-angle, comprehensive interaction, the optimal control of Coordinated Play
Oil, inhibiting bacteria and diminishing inflammation, anti-acne effect, by inhibiting the Active Regulation sebum secretion of lipoxidase and 5- alpha-reductase, from source
Achieve the purpose that oil-control；By adjusting cutaneous ecosystem (flora), diminishes inflammation, inhibit the development of small pox symptom；Pass through suppression
The peroxidating of free fatty acid processed reduces the active constituent of sebum peroxidating, inhibits the accumulation of small pox stimulant, plays toxin expelling solution
Malicious, anti-aging effect；By inhibiting cell factor relevant to fibrosis, promote small pox healing, and by promoting cutin de-
Melanin production is fallen and inhibited, pockmark is eliminated.Above main composition is mutually coordinated, mutual gain, has significant control
Oily acne-removing further adds allantoin, 1,3-BDO, dipropylene glycol and sodium carboxymethylcellulose, makes skin toner obtained
Aqueous nature is stablized, more excellent skin sense, replenishing water and preserving moisture significant effect.
Wherein, oriental wormwood parthenium extract has the bactericidal activity of wide spectrum, to staphylococcus aureus, staphylococcus epidermis and Cuo
Sore Propionibacterium has stronger killing effect, the inflammatory reaction for effectively inhibiting above-mentioned pathogenic bacteria to cause, and then reduces small pox
Growth.Flos Sophorae extract can inhibit the release of pre-inflammatory amines, and the excited adrenal cortex of energy, inhibit the permeability of capillary,
The sulfydryl for blocking a variety of enzymes inactivates a variety of enzymes for leading to inflammation, has splendid anti-inflammatory effects, the shape of small pox can be effectively suppressed
At alleviating the symptom of small pox, while also by inhibiting the Active Regulation sebum secretion of lipoxidase and 5- alpha-reductase, from source
Achieve the purpose that oil-control on head.Mulberry root extract has strong free radical scavenging ability, inhibits the activity of tyrosinase, has aobvious
Anti-oxidant, the white-skinned face function write inhibits pigmentation, effectively desalination pockmark, while having certain antibacterial activity, can enhance mattress
The bactericidal effect of old parthenium extract.The water-soluble fullerene oxidation resistance with super strength and lasting period is long, can remove various
Under the conditions of generated active oxygen, the various damages that free radical can be blocked to generate skin from source have significant anti-ageing
Whitening effect can enhance the desalination pockmark activity of mulberry root extract, while the water and oil balance of adjustable skin, enhancing sophora flower extract
The oil-control effect of object.Decoyl glycine has antibacterial, oil-control antiinflammation, can enhance oriental wormwood parthenium extract antibacterial activity and sophora flower
The oil-control effect of extract.Palmityl glycine can prevent clogging of pores, inhibit skin keratin, caused by reducing because of chronic inflammation
Aging, restore skin-balance；Promote Angiogenesis, reappears skin gloss；Help collagenous fibres network structure synthesis and
Arrangement makes skin restore consolidation.Endecatylene acyl glycine inhibits the activity of tyrosine kinase, reduces melanin production, is conducive to
Pockmark is eliminated, while having effects that skin whitening.
Compared with prior art, the invention has the following advantages:
(1) oil control and acne removal toner of the invention contain amino acid derivativges, water-soluble fullerene, oriental wormwood parthenium extract,
The multiple efficacies ingredient such as Flos Sophorae extract and mulberry root extract, can efficiently Sage Extract, help skin to continue oil-control, it is antibacterial to disappear
Inflammation maintains the normal ecosystem of skin, unimpeded pore, and blowdown promotes blood circulation except poison, and cutin is promoted to fall off and inhibit black
The effect of pigment generates, and various aspects play anti-acne in all directions, smooth acne scar, eliminate acne print, is very suitable to oiliness, whelk
Consumer use.
(2) oil control and acne removal skin toner aqueous nature of the invention is mild, safety and stability, and without skin irritation, skin is easy to inhale
It receives, it is clearly not sticky using rear face, and preparation process is simple, it is quality controllable.
Specific embodiment
The following examples are further illustrations of the invention, rather than limiting the invention.
Ingredient in following embodiment formula is unless otherwise instructed commercial product.Wherein, undecylenoyl benzene
Alanine CAS is 175357-18-3, is purchased from Xi'an Jia Boying Biotechnology Co., Ltd；Decoyl glycine CAS is
14246-53-8 is purchased from Guangzhou Mei Yi Biotechnology Co., Ltd；Palmityl glycine CAS is 2441-41-0, is purchased from Xi'an
Rui Xi Biotechnology Co., Ltd；Water-soluble fullerene RadicalSource area Mitsubishi VC60 is purchased from Guangzhou
Hundred Hao Bo Co., Ltds；Oriental wormwood parthenium extract is purchased from Xi'an Rayleigh Biotechnology Co., Ltd；Flos Sophorae extract is gloomy purchased from Shaanxi
Not natural product Co., Ltd；Mulberry root extract is purchased from Shaanxi Sen Fu natural product Co., Ltd；Allantoin CAS are as follows: 97-
59-6 is purchased from Guangzhou rain and dew Chemical Co., Ltd..
The preparation of embodiment 1-5 oil control and acne removal toner
The preparation of embodiment 1-5 oil control and acne removal toner includes the component of parts by weight shown in following table:
| Component | Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 |
| 1,3 butylene glycol | 2 | 3 | 1 | 2 | 1 |
| Dipropylene glycol | 4 | 2 | 5 | 2 | 3 |
| Allantoin | 2 | 3 | 1 | 2 | 1 |
| Decoyl glycine | 0.8 | 0.6 | 0.4 | 0.25 | 0.4 |
| Palmityl glycine | 0.8 | 0.6 | 0.4 | 0.125 | 0.4 |
| Endecatylene acyl glycine | 0.4 | 0.3 | 0.2 | 0.125 | 0.2 |
| Water-soluble fullerene | 1 | 1.5 | 0.5 | 1 | 0.5 |
| Oriental wormwood parthenium extract | 3 | 2 | 4 | 2 | 3 |
| Flos Sophorae extract | 2 | 2 | 2 | 1.5 | 2 |
| Mulberry root extract | 2 | 1 | 2 | 1.5 | 1 |
| EDTA- disodium | 0.05 | 0.03 | 0.04 | 0.02 | 0.03 |
| Sodium carboxymethylcellulose | 0.8 | 0.5 | 1 | 0.7 | 0.6 |
| Glycine betaine | 1.5 | 1 | 2.5 | 1.5 | 2 |
| Phenoxyethanol | 0.1 | 0.2 | 0.1 | 0.1 | 0.05 |
| Methyl hydroxybenzoate | 0.1 | 0.1 | 0.1 | 0.1 | 0.05 |
| Deionized water | 80 | 80 | 80 | 70 | 60 |
Preparation step: by the 1,3 butylene glycol of formula ratio, dipropylene glycol, allantoin, decoyl glycine, the sweet ammonia of palmityl
Acid, endecatylene acyl glycine, sodium carboxymethylcellulose, glycine betaine and deionized water mixing, are heated to 70 DEG C, and stirring makes it
It is completely dissolved, cools down 40 DEG C, water-soluble fullerene, oriental wormwood parthenium extract, Flos Sophorae extract, mulberry root extract, EDTA- bis- is added
Sodium, Phenoxyethanol and methyl hydroxybenzoate are uniformly mixed, discharge to obtain the final product.
The preparation of comparative example 1-7 oil control and acne removal toner
The preparation of comparative example 1-7 oil control and acne removal toner includes the component of parts by weight shown in following table:
Preparation step reference implementation example 1.
The test of one irritation of test example
(1) tested material: oil control and acne removal toner made from embodiment 1-5 and comparative example 1-7.
(2) by the requirement of " cosmetics safety technical specification " 2015 editions, select 120 ages 20~55 years old aspiration by
Examination person is used as subjects.120 subjects are equally divided into 12 groups, are tried out made from embodiment 1-5 and comparative example 1-7 respectively
Oil control and acne removal toner.
(3) experimental method: 0.2mL toner is taken to be put into spot tester (area 30mm2, depth 1mm) small interior, with low sensitization
Adhesive tape will be pasted on the forearm song side of subject added with the spot tester of toner, is gently pressed with palm and is allowed to equably be pasted on skin
On, after persistently sticking for 24 hours, 30min after taking away spot tester, for 24 hours with the standard sight dermoreaction of 48h following table and records sight
Examine result.
As the result is shown: the dermoreaction degree of all subjects is-, grading system 0.Illustrate embodiment 1-5 and right
Oil control and acne removal toner made from ratio 1-7 is highly-safe to no skin irritation.
The detection of two physical and chemical index of test example
(1) tested material: oil control and acne removal toner made from embodiment 1-5 and comparative example 1-7.
(2) Testing index: character, pH value, cold and hot stability, room temperature stability.
(3) testing result:
1. character: this product is suitable for achromaticity and clarification clear homogeneous for viscosity, the fresh and elegant solution of smell.
2. pH value: it is 6.5~7.2 that this product, which measures pH value,.
3. cold and hot stability: toner being packaged in transparence cosmetic bottle, in 4 DEG C of one month observation nothing of refrigerator cold-storage
Denaturalization phenomenon；In for 24 hours, toner is without phenomena such as spoiled, rotten in 55 DEG C of insulating box.
4. room temperature stability: toner being placed in bottle for cosmetics, investigation 6 months is stored at room temperature, no lamination uses
After feel unchanged, smell is unchanged, no denaturalization phenomenon.
Three bacteriostatic test of test example
It prepares propionibacterium acnes, staphylococcus aureus, staphylococcus epidermis plate respectively using double-layer agar technique, puts down
Plate bacteria containing amount is 104~105CFU/ plate is accurate to measure oil control and acne removal skin toner made from 0.2mL embodiment 1-5, comparative example 1-7
Water is uniformly applied on plate containing bacterium with aseptic cotton carrier, is cultivated 24 hours under anaerobic condition at 36 ± 1 DEG C, is then observed plate
Interior bacterium colony growth, the results are shown in Table 1.
1 each group fungistatic effect of table compares
The results show that oil control and acne removal toner made from embodiment 1-5 is showed no propionibacterium acnes, Staphylococcus aureus
Bacterium and the growth of staphylococcus epidermis bacterium colony, show sample to propionibacterium acnes, staphylococcus aureus and staphylococcus epidermis
Inhibitory effect it is stronger, sample anti-acne effect is good.
By comparative example 1 it is found that being free of water-soluble fullerene in formula, the bacteriostatic activity of sample is not influenced.By comparative example
2-3 is it is found that be formulated while being free of decoyl glycine, palmityl glycine and endecatylene acyl glycine, or be free of palm simultaneously
The bacteriostatic activity of acyl glycine and endecatylene acyl glycine, sample reduces, and shows that the above 3 derived from amino acid object compounding has
Preferable bacteriostatic activity.By comparative example 4-7 it is found that formula is extracted without oriental wormwood parthenium extract, Flos Sophorae extract and Sang Gen respectively
Object, or above 3 Plant Extracts are free of simultaneously, the bacteriostatic activity of sample is substantially reduced, especially to be free of oriental wormwood parthenium extract,
Or the bacteriostatic activity without 3 Plant Extracts is poor simultaneously.It is preferably antibacterial to show that the above 3 Plant Extracts compounding has
Activity.In conclusion each ingredient of oil control and acne removal toner of the invention is mutually coordinated, splendid fungistatic effect is played.
Four oil-control of test example, anti-acne test
Screening male trial volunteer 144, the age 18-35 years old, all trial volunteers were oily skin, and are suffered from
There is acne, clinical symptoms and sign meet homeliness type acne diagnostic criteria, and lesion degree meets Chinese acne treatment guide classification
I~II grade of method, I grade (slight): only acne；II grade (moderate): there are also inflammatory papules other than acne, determine curative effect: subtracting
Few rate=(cutaneous inflammatory lesion number after dermatitis skin lesion number-treatment before treating)/dermatitis skin lesion number × 100% before treating.Substantially it fullys recover from an illness
More: cutaneous inflammatory lesion number reduces >=90%；Effective: cutaneous inflammatory lesion number reduces 60~89%；It improves: cutaneous inflammatory lesion number reduction 20~
60%；Invalid: cutaneous inflammatory lesion number reduces < 20% or aggravates.Total effective rate=(effective+recovery from illness+improvement number of cases)/total number of cases ×
100%.
All trial volunteers without skin allergy history, meet subject enrollment standard, can cooperate experiment very well, study
Period is able to maintain regularity in one's life.Trial volunteer is divided into 12 groups, every group of 12 people, respectively test 1-5 group and comparison 1-7
Group, wherein test 1-5 group is made using oil control and acne removal toner made from embodiment 1-5, comparison 1-7 group using comparative example 1-7
Oil control and acne removal toner.
Test method: cheek, temple and corners of the mouth intersection at experiment septum reset or so cheekbone, nose and pupil intersection or so
Locate left and right sides as test area.Trial volunteer is early daily, evening adheres to using corresponding tested products.Experiment starts rear 15
It, progress follow-up in 30 days, test subject is changed using the skin moisture content after product, fat content respectively, the same will
The test of hope person is completed by the same survey crew.In the 0th day, 15 days, progress clinical test results assessment in 30 days.
Wherein, the measurement of skin oil and fat content: the skin oil and fat produced using Courage+Khazaka (CK) company of Germany
Content measuring instrument Sebumeter is surveyed 5 times and is averaged.The measurement of skin moisture content: Germany Courage+Khazaka is used
(CK) the moisture of skin tester Corneometer CM825 of company's production, which is surveyed 5 times, is averaged.Test result is referring to table 2.
Statistics is after 30 days, the recovery from illness situation and acne print of each group trial volunteer's facial acne desalination or the case where subside,
It the results are shown in Table 3.
The skin oil and fat of 2 each group trial volunteer of table, moisture content test result
The acne-removing inflammation-diminishing effect of each test group of table 3
Table 2 shows that oil control and acne removal toner made from 1-5 of the embodiment of the present invention can obviously improve trial volunteer face
Water and oil balance, effect are substantially better than the using effect of oil control and acne removal toner made from comparative example 1-7.Show that oil-control of the present invention is dispelled
Acne toner can change the microcirculqtory system of skin, adjust skin water and oil balance, mitigate and eliminate the generation of acne.
Table 3 shows, the effect that the acne-removing inflammation-diminishing of oil control and acne removal toner made from 1-5 of the embodiment of the present invention, acne print are eliminated
Significantly, what acne-removing inflammation-diminishing and acne print were eliminated is efficient up to 91.7% or more, can obviously reduce acne cutaneous inflammatory lesion number, mitigates skin
The senses of discomfort such as skin redness, inflammation, desalination or recession acne print, effect is better than oil control and acne removal toner made from comparative example 1-7.
The above is only the preferred embodiment of the present invention, it is noted that above-mentioned preferred embodiment is not construed as pair
Limitation of the invention, protection scope of the present invention should be defined by the scope defined by the claims..For the art
For those of ordinary skill, without departing from the spirit and scope of the present invention, several improvements and modifications can also be made, these change
It also should be regarded as protection scope of the present invention into retouching.
Claims (8)
1. a kind of oil control and acne removal toner, which is characterized in that including following components and its parts by weight: 1,3-BDO 1~3
Part, 2~5 parts of dipropylene glycol, 1~3 part of allantoin, 0.5~2.5 part of amino acid derivativges, 0.5~1.5 part of water-soluble fullerene,
5~8 parts of plant extracts, 0.02~0.05 part of EDTA- disodium, 0.5~1 part of sodium carboxymethylcellulose, 0.5~2 part of glycine betaine,
0.1~0.3 part and 60~80 parts of deionized water of preservative.
2. oil control and acne removal toner according to claim 1, which is characterized in that including following components and its parts by weight:
2 parts of 1,3 butylene glycol, 4 parts of dipropylene glycol, 2 parts of allantoin, 2 parts of amino acid derivativges, 1 part of water-soluble fullerene, plant extract
7 parts of object, 0.05 part of EDTA- disodium, 0.8 part of sodium carboxymethylcellulose, 1.5 parts of glycine betaine, 0.2 part of preservative and deionized water 80
Part.
3. oil control and acne removal toner according to claim 1 or 2, which is characterized in that the plant extracts is oriental wormwood
Parthenium extract, Flos Sophorae extract and mulberry root extract are with (2~4): (1.5~3): the mass ratio of (1~2) forms.
4. oil control and acne removal toner according to claim 3, which is characterized in that the plant extracts mentions for Artemisia capillaris
Object, Flos Sophorae extract and mulberry root extract is taken to form with the mass ratio of 3:2:2.
5. oil control and acne removal toner according to claim 1 or 2, which is characterized in that the amino acid derivativges are pungent
Acyl glycine, palmityl glycine, endecatylene acyl glycine are with 1:(0.5~1): the mass ratio of (0.1~0.5) forms.
6. oil control and acne removal toner according to claim 5, which is characterized in that the amino acid derivativges are that decoyl is sweet
Propylhomoserin, palmityl glycine, endecatylene acyl glycine are formed with the mass ratio of 1:1:0.5.
7. oil control and acne removal toner according to claim 1 or 2, which is characterized in that the preservative is selected from ethoxy
One of urea, Phenoxyethanol, Sensiva SC50, methylisothiazolinone, Chlorphenesin, methyl hydroxybenzoate or ethyl hydroxy benzoate with
On.
8. a kind of method for preparing oil control and acne removal toner described in claim 1, which comprises the following steps:
By the 1,3 butylene glycol of formula ratio, dipropylene glycol, allantoin, amino acid derivativges, sodium carboxymethylcellulose, glycine betaine and
Deionized water mixing is heated to 70 DEG C, and stirring makes it completely dissolved, and cools down 40 DEG C, and water-soluble fullerene, plant extract is added
Object, EDTA- disodium and preservative are uniformly mixed, discharge to obtain the final product.
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| CN110711166A (en) * | 2019-11-03 | 2020-01-21 | 广州悦荟化妆品有限公司 | Toner with oil control and moisture retention effects |
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| CN117064777A (en) * | 2023-07-26 | 2023-11-17 | 妆莱(广州)生物研究有限公司 | Composition and application thereof in improving skin barrier and skin care product |
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| CN117064777B (en) * | 2023-07-26 | 2024-06-11 | 妆莱(广州)生物研究有限公司 | Composition and application thereof in improving skin barrier and skin care product |
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