CN108186679A - A kind of acne-removing composition - Google Patents
A kind of acne-removing composition Download PDFInfo
- Publication number
- CN108186679A CN108186679A CN201810124686.3A CN201810124686A CN108186679A CN 108186679 A CN108186679 A CN 108186679A CN 201810124686 A CN201810124686 A CN 201810124686A CN 108186679 A CN108186679 A CN 108186679A
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- Prior art keywords
- grease
- acne
- fullerene
- removing composition
- composition
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
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Abstract
The invention discloses a kind of acne-removing composition, the raw material that the composition includes following weight percentage is made：Active constituent 1 5%, emulsifier 1 5% containing fullerene, skin conditioning agent 1 5%, moisturizer 5 20%, excess water, the composition have anti-acne, analgesic, antipruritic, repair the effect of scar.
Description
Technical field
The present invention relates to anti-acne field, the acne-removing composition product formula more particularly to containing fullerene.
Background technology
There are many kinds of the reason of causing acne and small pox, probably vigorous including following smegma；2. cutin alienation；3
Propionibacterium acnes are grown；4th, inflammatory reaction.Acne, papule, tubercle, tumour four-stage skin are divided into according to severity performance
Skin damages.Acne is clinically divided into three degree, 4 grades according to the property of skin injury and severity.1 grade (slight) only has powder
Thorn；2 grades (moderates) also have some inflammation papules in addition to acne；3 grades (moderates) in addition to acne, also more inflamed papules and/
Or useless fellow, 4 grades (severes) in addition to having acne, inflamed papules grade useless fellow, are harmful to tubercle, tumour.In the prior art mainly according to shape
Into reason for treatment.
1st, the adjusting hormone in vivo diacrisis of hormone secretion exception, estradiol is reduced or testosterone increases, and leads to skin
Middle testosterone/estradiol value raising, testosterone value is opposite to be increased, meanwhile, there are some specific reductions in hair follicle and sebocyte cell
Enzyme, particularly 5α-reductase and 3 β, 17 beta-hydroxysteroid dehydrogenases, these enzymes can make testosterone in androgen be converted into protona,
Protona is combined again with the receptor in sebocyte cell, stimulates hyperplasia and the secretion of sebocyte cell；In addition, by promoting skin
The synthesis of skin intracellular nucleic albumen and the glycolysis access for energy needed for synthesis lipid, stimulation sebocyte cell period add
Fast and lipid synthesis acnes mitigate the state of an illness mainly since the extremely caused parasteatosis of 3male hormone secretion causes
A kind of method is that the pregnant fat of adjusting promises-female alcohol of determining of increase female hormone is to first pass around FDA (food and drug admin
Istration, U.S.'s food and Drug Administration) that permits is used to treat the low dose oral contraceptives of acne, oral contraception
The apparent side effect of medicine is headache, nausea, bleeding, weight gain and breast tenderness etc..The anti-androgen therapy of acne is studied
Showing, antiandrogen drug is mainly the inhibitor or antagonist of androgen receptor, in being suitable for, the treatment of mild acne,
There are high specificity, Small side effects.Another method is then to use 5α-reductase and 3 β, 17 beta-hydroxysteroid dehydrogenations
The inhibitor of the specific reductions enzyme such as enzyme, such as, according to molecular structure, 5α-reductase inhibitor is divided into steroidal and nonsteroidal；
According to 5α-reductase specificity difference, it is divided into specificity 5α-reductase I and II inhibitor of 5α-reductase and dual 5 α-R suppressions
Preparation.
2. for exfoliating
The keratinocyte of basal layer and follicle keratinocytes abnormal differentiation, these exceptions can lead to the Asia oil in sebum
Acid reduces, and linoleic acid is the essential fatty acid of Hair follicle epithelial cells growth, and linoleic acid shortage can cause keratinocyte change
It is close, sebaceous gland duct epithelium layer is caused constantly to thicken, caliber becomes smaller, it is unobstructed degree weaken, eventually lead to pilosebaceous follicle and lead
Pipe acute occlusion, hair follicle swells and forming acne dissolving cutin can make cuticula thicken improvement, removes ripe acne, and can press down
Micro mist thorn processed, improves other penetrability for sharing anti-acne drug, such as Tretinoin has cutin dissolution, not only can be pre-
Anti- recurrence can also maintain acne relieved state, and in addition Tretinoin has moderate anti-inflammatory effect, can treat cutaneous inflammatory lesion and use beveling
Matter chemical drug object should be noted that its newfound side effect:Excessive keratinization, or the size of taking dose can cause skin centainly
The damage of degree, and the influence to its hetero-organization.
3. antimicrobial and anti-inflammatory
When acne occurs, keratinocyte expression Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 (a kind of neuropeptide substance), while discharge inflammation because
Son promotes mast cell degranulation, activates neutrophil leucocyte and macrophage, can also cause inflammatory reaction in no bacterium
In the presence of inflammatory factor, in addition conduit blocking, sebum also can individually induce the inflammation of acne, the biomembrane of bacterium is by cell
Exo polysaccharides body is formed, these polysaccharide calcium frame polymers can form a protective outer skeleton, play the role of physical barrier,
And influence, prevent the therapeutic effect of the various effective antibacterials in biomembrane microenvironment current, have and resisted by oral administration and externally
The raw treatment for usually realizing antibacterial, anti-inflammatory effect, but antibiotic for oral administration should be noted that whether it with compound medicine has interaction, stomach
Enteron aisle side effect should be smaller, while is easily developed immunity to drugs using antibiotic and dependence, usually Multiple Classes of Antibiotics cooperation make
With application blue-reds light irradiate etc. physical means, by photodynamics can destroy propionibacterium acnes and reduce inflammation reaction this
Kind light treatment method has a better effect acne and can avoid the potential radiological hazard of UV methods
4. scar eliminating
The scar that skin is formed is destroyed after acne is cured, when inflammation occurs not eliminate, and is commonly used to repair acne at present
Skin lesion and the vegetable active raw material that effectively prevention blackening generates have:SOD (supero xide dis mutase superoxide dismutases
Enzyme), Mao Qingdong glycosides, alkannin, hypocrellin A, forskolin, sponge gourd saponin(e, Gotu Kola P.E etc..
The disclosed treatment acne compositions of patent CN201410086670 include salicylic acid, pentanediol, 2-pyrrolidone-5-carboxylic acid
One or more in zinc, certain herbaceous plants with big flowers glycol, allantoin, which has mainly played salicylic acid exfoliating anti-acne effect, adds in allantois
Element promotes cell production, accelerates wound healing, the effect of cutin-softening albumen.But the same Tretinoin of salicylic acid is used in the patent
Equally there is cutin dissolution, can not only prevent to recur, can also maintain acne relieved state, but excessive keratinization,
Or the size of taking dose can cause skin a degree of damage and the influence to its hetero-organization, suffer from the patent
The sufferings feeling of person does not mitigate, and pockmark does not solve.CN201410386421 discloses a kind of mild effective removing acnes and controlling oil
Composition, including Sodium Hyaluronate, glycerine, propylene glycol, hydroxy ethyl fiber line, urea capsule, D-pantothenyl aleohol, totara tree extraction
Object, ethyl alcohol, white willow bark extract, purslane extract etc..It mainly by improving the moistening effect of skin, adjusts skin oil
Ester balances, and inhibits sebum excessive secretion, the breeding of propionibacterium acnes is inhibited to achieve the effect that oil control and acne removal.In the patent for
The acne treatment effect of middle severe is poor, especially weak to the recovery effects of scar.CN201510449840 is disclosed containing fowler
The skin-rehabilitating agent of alkene soluble derivative, including fullerene water soluble derivatives, iodine, iodine stabilizer, iodine complexing agent, allantoin
Deng, contain in the invention in the skin-rehabilitating agent of fullerene water soluble derivatives using fullerene water soluble derivatives as mainly into
The skin-rehabilitating agent divided, the allantoin gel preparation with strong bactericidal agent iodine complexing agent and containing moisturizing ingredient are used cooperatively,
The bacterium of the wound face on damaged skin surface can not only be efficiently killed, promotes the reparation and regeneration of damaged cell, hence it is evident that improves scabies
The symptoms such as itch, there is no the pockmark repair left for small pox or acne in the patent.
It summarizes with upper type, inhibits the anti-inflammatory components side effect such as androgens medicine and antibiotic larger, be not suitable for long-term
It uses or from the treatment for acne caused by a kind of mechanism, using being limited, cure rate is low.Prior art product for resolving poxes is only
It can solve the problems, such as anti-acne, acne print residual later is a more stubborn problem, with the sufferings impression during duration acne
The quality of life of patient, which can be reduced, also not to be improved.Therefore, being badly in need of a kind of product at present can work along both lines, can be polygonal
Degree various aspects solve the problems, such as small pox and pockmark, improve the pain of patient.
Invention content
In order to solve the above-mentioned technical problem, the purpose of the present invention is to provide a kind of acne-removing composition, main actives
Be by fullerene, allantoin compatibility collaboration play curative effect, the composition can effective removing acne, whelk, physiology phase acne,
Acne caused by endocrine disorder, and can be experienced with the sufferings of rapid recovery long acne phase, do not stay pockmark after anti-acne.
The present invention is achieved through the following technical solutions：
A kind of acne-removing composition is made of the raw material of following weight percentage：
Active constituent 1-5%, emulsifier 1-5%, skin conditioning agent 1-5%, moisturizer 5-20% containing fullerene, surplus
Water.
Further preferably, a kind of acne-removing composition is made of the raw material of following weight percentage：
Active constituent 2-4%, emulsifier 2-4%, skin conditioning agent 2-4%, moisturizer 8-15% containing fullerene, surplus
Water.
Further preferably, a kind of acne-removing composition is made of the raw material of following weight percentage：
Active constituent 3.6%, emulsifier 3.25% containing fullerene, skin conditioning agent 3.8%, moisturizer 12%, surplus
Water.
Active constituent containing fullerene of the present invention refers to by fullerene powder, aqueous fullerene or oiliness fullerene
Any composition with vegetable oil esters.The fullerene powder, water-soluble fullerene or oiliness fullerene and vegetable oil esters are pressed
According to weight ratio (3-8):(0.2-1.5) is formed.Further preferably, the fullerene powder, water-soluble fullerene or oiliness fowler
Alkene is with vegetable oil esters according to weight ratio (4-6):(0.5-1) is formed.Most preferably, the fullerene powder, water-soluble fullerene or oil
Property fullerene and vegetable oil esters according to weight ratio 5:1 composition.
In the above-mentioned technical solutions, the fullerene is empty fullerene and/or metal fullerene.Including but not limited to
Fullerene C2n、M@C2n、M2@C2n、MA@C2n、M3N@C2n、M2C2@C2n、M2S@C2n、M2O@C2nAnd MxA3-xN@C2nAny one of,
Wherein, M and A is metallic element, and the M and A are selected from any one in Sc, Y and lanthanide element；30≤n≤60；
0≤x≤3。
Further preferably described fullerene selection C60、C70、C76、C84, Gd@C82, SC3N@C80One or more of mixing
Object.
The vegetable oil esters include but not limited to the extract of vegetable seeds, flower, rhizome etc., such as olive grease, greatly
Soya-bean oil ester, linseed grease, prinsepia utilis royle oil ester, rapeseed grease, dessert almond grease, sunflower grease, kardiseed grease, grape pip
Grease, oenothera biennis grease, Common Borage seed grease, Radix Angelicae Sinensis grease, ginger grease, Jojoba grease, walnut grease, avocado grease,
Mango grease, castor oil ester, almond grease, shea butter ester, fructus rosae grease, coconut grease, lavender grease, palm oil
Ester, cavings grease, wheat embryo grease, pot marigold grease, aloe grease, palm grease, Ah's glyceride, dessert almond grease are beautiful
The mixture of the one or more such as rice bran oil ester.Further preferred grape pip grease, ginger grease, Jojoba grease, lavender oil
It is a kind of in ester；Most preferably Jojoba grease.
Fullerene in formula has the function of to treat acne, apparent especially for the recovery effects of scar, but by
In fullerene hydrophobicity, cause to absorb slowly, bioactivity effect is low.The fullerene of the present invention with vegetable oil esters by compounding, energy
It is enough that fullerene is distributed in vegetable oil esters, the absorption of fullerene can be promoted, improve bioavilability, while vegetable oil esters are also
Anti-acne effect is played with collaboration fullerene.Especially inventor has found the skin conditioning agent of fullerene compatibility and the present invention, protects
The auxiliary materials such as humectant, emulsifier promote the absorption of fullerene and produce the synergistic effect for the treatment of acne.
Aqueous fullerene of the present invention, oiliness fullerene are the prior art.Can according to WO2013/0251/80A1,
The preparations such as CN201210406707A.
Skin conditioning agent of the present invention includes but not limited to allantoin, atoleine, liquid petrolatum, myristic acid isopropyl
Ester, isopropyl palmitate, palmitic acid 2- ethylhexyls, unrighted acid, such as oleic acid palmitic acid, stearic acid, behenic acid, Asia
The mixture of the one or more such as oleic acid, 16/18 alcohol, Polyquaternium-10 (PQ400).Further preferred skin conditioning agent includes
Allantoin, 16/18 alcohol, Polyquaternium-10 (PQ400) are according to weight ratio 0.1-1:1-5:0.1-0.5 is formed.Still more preferably
Skin conditioning agent is according to weight ratio 0.5 by allantoin, 16/18 alcohol, Polyquaternium-10 (PQ400):3:0.3 composition.
The allantoin of the present invention makes it combine the ability enhancing of water, promotes cutin also with that can directly act on keratin
Cutin-softening albumen is relaxed, promotes cell growth, accelerates wound healing, auxiliary is played for the treatment acne effect of fullerene
Effect.Allantoin of the present invention is trade name, and the entitled Allantoin of chemistry can purchase.
16/18 alcohol plays the role of moisturizing, has good sense of touch substance, presents skin after smearing smooth, soft
The feeling of soft lubrication.
Polyquaternium-10 described in above-mentioned skin conditioning agent.Polyquaternium-10 (PQ400), Chinese nickname:Chlorination -2-
Hydroxyl -3- (dimethylamino) propyl polyethylene oxide cellulose ether, No. CAS:68610-92-4.Polyquaternium-10 solution with
Moisture evaporation, Polyquaternium-10 form reticular structure due to intermolecular interaction, and certain moisture can be kept by forming epithelium,
Simultaneously because the effect that film forming quickly absorbs.Polyquaternium-10 improves skin uvioresistant for feeling after the splendid use of skin
Ability, excellent moisturizing performance, also with anti-rinse capability.
The selection for the skin conditioning agent that the present invention selects and proportioning can be good at cooperateing with the treatment of fullerene active constituent
The effect of acne, which is simultaneously played, strengthens elimination and improvement to scar, makes skin lubrication fine and smooth, have excellent spreadability, lubricity,
Moist type, moisture retention and gas permeability.
Moisturizer of the present invention is glycerine, butanediol, polyethylene glycol, propylene glycol, hexylene glycol, xylitol, poly- the third two
It is one or more of in alcohol, D-sorbite, IPP, vaseline, dimethyl silicone polymer, Sodium Hyaluronate.
Further preferably, moisturizer is glycerine, vaseline, isopropyl palmitate, dimethyl silicone polymer are according to parts by weight
Than (2-10):(2-5):(1-5):(1-5) is compounded.
Further preferably, moisturizer is glycerine, vaseline, isopropyl palmitate, dimethyl silicone polymer are according to parts by weight
Than (4-6):(2-4):(1-3):(1-3) is compounded.
Still more preferably, moisturizer is glycerine, vaseline, isopropyl palmitate, dimethyl silicone polymer are according to weight
Part ratio 5:3:2:2 compoundings.
The moisturizer of the present invention, inventor are had found common largely using small molecule moisturizer such as glycerine, propylene glycol, fourth two
Alcohol etc., their molecules have hydroxyl, after on the skin, rely on hydrogen bond, the moisture inside skin care item can be caught and be stopped
On the skin.This micromolecular moisturizer, molecular weight is small, and permeability is strong, is easily accessible horn cell gap, but such small point
Sub- moisturizer amount of filling can generate stimulation phenomenon when being more than 8%, especially in cosmetics containing grease, emulsifier when ingredients
In order to enhance moisture retention, need to add in a large amount of small molecule ingredient glycerine etc., but irritation enhances therewith.In order to avoid strong
Irritation, the present invention moisturizer combination in add isopropyl palmitate, its play the role of moisturizing and skin care, skin
Skin is preferable to the absorbability of this product, can effectively be contacted with hair follicle in cortex, penetrates into cortex depths, and by the activity in cosmetics
Component is brought into, gives full play to the effect of active ingredient.Vaseline, dimethyl silicone polymer all play smooth skin sense.The present invention protects
The film forming of polyquaternium in the selection and skin conditioning agent of humectant can preferably coordinate moisture-keeping function.
Emulsifier of the present invention, preferably hexadecyltrimethylammonium chloride (1631), docosyl alcohol and arachidic alcohol glucoside
(CS200), polyethylene glycol (100) stearate and tristerin (E165), stearic acid, anhydrous sorbitol sesquialter oleic acid
Ester, polyethylene glycol -30, hexadecyltrimethylammonium chloride, dimerization hydroxy stearic acid ester, lecithin, it is a kind of in magnesium stearate or
More than.Further preferred hexadecyltrimethylammonium chloride, docosyl alcohol and arachidic alcohol glucoside, polyethylene glycol (100) stearic acid
Ester and tristerin are according to weight ratio (0.1-1):(1-5):(0.5-2) is compounded.Still more preferably cetyl front three
Ammonium chloride, docosyl alcohol and arachidic alcohol glucoside, polyethylene glycol (100) stearate and tristerin are according to weight ratio
0.25:2:1 compounding.Emulsifier compounding can make lotion fine and smooth beautiful, and using effect is best.Wherein cetyl trimethyl chlorination
Ammonium has good stability, deflocculant.
As the ingredient that can coordinate, preservative, aromatic etc. can also be added in composition of the invention.
It is preferably added to preservative the dosage 0.2-1%, preferably 0.5-0.8% of composition.The preservative includes water solubility
Preservative, oiliness preservative.Preferably select methyl hydroxybenzoate, propylben, Phenoxyethanol, Sensiva SC50, tertiary butyl
More than one in hydroquinone.In order to reach preferable antisepsis and sterilization effect, using a kind of preservative often seriously beyond safety
Dosage brings security risk.Further preferred preservative selection methyl hydroxybenzoate：Propylben：Phenoxetol/first
Base isothiazolinone is (0.5-2) according to weight part ratio:(0.5-2):(2-5) is compounded.Further preferably, preservative selection Ni Bo
Tortoise beetle ester：Propylben：Phenoxetol/methylisothiazolinone is according to weight part ratio 1.2:1:4 compoundings.Present invention compounding
Preservative system there is synergetic antibacterial effect, reducing respectively safely and effectively under the premise of usage amount, compound use still can be protected
Enough sterilizing abilities are held, and safety is without side-effects.It is also avoided that secondary pollution, especially to the bactericidal effect of mould, extends
The shelf-life of product and it ensure that product quality.
The aromatic consumption is 0.01-0.05%.
All moisturizer of the present invention, skin conditioning agent, emulsifier, preservative, aromatic, active matter can be purchased in market.
Advantageous effect
1st, the acne-removing composition that the selection of inventive compound, auxiliary material is obtained by scientific matching modulation and preparation process
With anti-acne, analgesic, antipruritic, the effect of scar is repaired.A kind of acne-removing composition anti-acne of present invention offer is significant in efficacy, to the group
Close object can effective removing acne, whelk, physiology phase acne, acne caused by endocrine disorder, and can be long with rapid recovery
The sufferings impression of acne phase, anti-acne do not stay print later.
2nd, the present composition is highly susceptible to through keratoderma, it is easier to absorb and utilize, effect is easier to play.
3rd, the present composition is not recurred for the patients with acne curative effect of middle severe is best, cure rate is high.Extremely short
The redness of acne is eliminated in time, alleviates sufferings symptom so that small pox is quickly eliminated, and after use this patent product, anti-acne
Any trace is not stayed later.
4th, present composition irritation is small, without side-effects, can be used for a long time.
5th, composition of the invention is stablized, convenient storage, not stratified under high and low temperature environment, does not flocculate.
6th, composition of the invention is fine and smooth, mild, patch skin is strong, tends to smear out and absorbs.
7th, the protective system of the compounding of inventive formulation, broad-spectrum antiseptic, dosage is few after compounding and the safety is improved.
Description of the drawings
Fig. 1 is according to present composition process flow chart.
Fig. 2A-Fig. 2 C are the design sketch before and after product beta test according to the present invention, and Fig. 2A is before use, Fig. 2 B are to use the
Two days, Fig. 2 C were using after 1 week.
Specific embodiment
The specific embodiment of the present invention is described in detail below, it is to be understood that protection scope of the present invention is not
It is restricted by specific implementation.
1 embodiment 1-5 of table
Preparation process：The similar raw materials of the A weighed up are put into water phase pot, 85 DEG C is stirred and heated to, is stirring evenly and then adding into C
Phase raw material puts into the similar raw materials of the B weighed up in oil phase pot and is completely dissolved in 85 DEG C.Emulsification pot is preheated to 60-70 DEG C, is taken out true
Suction enters water phase and oil phase, and homogeneous (4000r/min) stirring is cooled to 45 DEG C and adds in D, E, discharges after being stirred until homogeneous.Half into
Product are filling after the assay was approved, product inspection warehousing after passing.
2 embodiment 6-10 of table
Preparation process：The similar raw materials of the A weighed up are put into water phase pot, 85 DEG C is stirred and heated to, is stirring evenly and then adding into C
Phase raw material puts into the similar raw materials of the B weighed up in oil phase pot and is completely dissolved in 85 DEG C.Emulsification pot is preheated to 60-70 DEG C, is taken out true
Suction enters water phase and oil phase, and homogeneous (4000r/min) stirring is cooled to 45 DEG C and adds in D, E, discharges after being stirred until homogeneous.Half into
Product are filling after the assay was approved, product inspection warehousing after passing.
One anti-acne effect of test example is tested
Drug：The acne-removing composition of Example 1,
Experimental group：20 Adolescent male A groups are chosen, 20 puberty women carry out test b group, 40 subjects year
Age between 14-24 Sui, acne mostly caused by hormone or endocrine disorder.Choose 30 nearly physiology phases of physiology, women, age
In 35-45 Sui C group, 30 women habitual menstrual period long acne, and acne can form shallow spot after eliminating after previous menstrual period.It chooses
Working clan of the age at 30-40 Sui, 20 D groups of male, 20 E groups of women because life and work is irregular, often stay up late for work,
Often there is long acne situation.More than experimenter, during Evaluation product, all diet and living habit do as usual, firm from every acne
Begin to use when growing, and be recorded as first day.
Application method：Local application is applied at acne or at acne print, is gently massaged into absorption
As a result：It is shown in Table 3, attached drawing 2 can be with by the experimental result to long acne crowd under different age group and different reasons
Find out, this patent product can in very short time second day just eliminate acne redness, alleviate sufferings symptom so that small pox is fast
Speed is eliminated, and using after this patent product, does not leave any trace after long acne.
Table 3
As seen from Table 3, composition of the invention is most apparent to frequent long acne crowd effect, especially to the improvement of acne print.
Test example two, the synergy of acne-removing composition of the present invention
By the way of Blind Test, 40 patients with acne are chosen, grouping is tested, and every group of subject 10 tries out respectively
The product of following different ratio is shown in Table 4
Contrast groups 1：Embodiment 1 is free of Jojoba grease
Contrast groups 2：Embodiment 1 does not contain allantoin
The synergistic effect of 4 present composition of table
As seen from Table 4, the composition anti-acne effect containing vegetable oil esters, which is better than, does not contain vegetable oil esters and without allantoin
Composition, vegetable oil esters and fullerene shared with synergistic effect, and allantoin can promote the reparation scar of the present composition
Trace acts on.From the data of embodiment 1-3 and embodiment 6 as it can be seen that the compositional selecting of embodiment 1-3 is better than the effect of embodiment 6.From
The data of embodiment 1-3 are as it can be seen that the prescription proportioning effect of embodiment 1 is best.
The composition of all embodiments of the invention and right is respectively provided with said effect.
The Selection experiment of test example three, protective system
According to U.S.'s cosmetics, washing product and essence federation (CTFA methods).The product 100g of different protective systems is weighed,
Be separately added into the container of sterilizing, each to add in 1ml golden yellow glucose coccuses, Escherichia coli, Pseudomonas aeruginosa, Candida albicans and
Black-koji mould shakes up.In the 0th, 7,14,21,28 day sampling analysis for connecing bacterium.If plus 7 days survival bacterium amounts are 100CFU/g after bacterium
Hereinafter, be all down to 0 in 28 days, it is considered as outstanding, passes through challenge.If bacterium amount of surviving at 7 days is exerted oneself 1000 hereinafter, being considered as
Pass through by force, if surviving bacterium amount at 7 days more than 1000, be considered as not over preservation challenge.It the results are shown in Table 5
Table 5
The description of the aforementioned specific exemplary embodiment to the present invention is in order to illustrate and illustration purpose.These descriptions
It is not wishing to limit the invention to disclosed precise forms, and it will be apparent that according to the above instruction, can much be changed
And variation.The purpose of selecting and describing the exemplary embodiment is that explain that the specific principle of the present invention and its reality should
With so that those skilled in the art can realize and utilize the present invention a variety of different exemplary implementations and
Various chooses and changes.The scope of the present invention is intended to be limited by claims and its equivalents.
Claims (10)
1. a kind of acne-removing composition, which is characterized in that the raw material including following weight percentage is made：Containing fullerene activity into
Divide 1-5%, emulsifier 1-5%, skin conditioning agent 1-5%, moisturizer 5-20%, excess water.
2. a kind of acne-removing composition as described in claim 1, which is characterized in that include the raw material system of following weight percentage
Into：Active constituent 2-4%, emulsifier 2-4%, skin conditioning agent 2-4%, moisturizer 8-15% containing fullerene, excess water；It is excellent
Select the active constituent 3.6% containing fullerene, emulsifier 3.25%, skin conditioning agent 3.8%, moisturizer 12%, excess water.
3. a kind of acne-removing composition as claimed in claim 1 or 2, it is characterised in that：The active constituent containing fullerene
Refer to by any composition with vegetable oil esters in fullerene powder, aqueous fullerene or oiliness fullerene；The fullerene
Powder, water-soluble fullerene or oiliness fullerene and vegetable oil esters are according to weight ratio (3-8):(0.2-1.5) is formed；It is it is preferred that described
Fullerene powder, water-soluble fullerene or oiliness fullerene and vegetable oil esters are according to weight ratio (4-6):(0.5-1) is formed.
4. a kind of acne-removing composition as claimed in claim 3, it is characterised in that：The vegetable oil esters be olive grease, soybean
Grease, linseed grease, prinsepia utilis royle oil ester, rapeseed grease, dessert almond grease, sunflower grease, kardiseed grease, grape seed oil
Ester, oenothera biennis grease, Common Borage seed grease, Radix Angelicae Sinensis grease, ginger grease, Jojoba grease, walnut grease, avocado grease, awns
Fruit grease, castor oil ester, almond grease, shea butter ester, fructus rosae grease, coconut grease, lavender grease, palm grease,
Cavings grease, wheat embryo grease, pot marigold grease, aloe grease, palm grease, Ah's glyceride, dessert almond grease, corn oil
The mixture of the one or more such as ester.
5. a kind of acne-removing composition as claimed in claim 4, it is characterised in that：The vegetable oil esters are Jojoba greases.
6. a kind of acne-removing composition as described in claim 1, it is characterised in that：The skin conditioning agent include allantoin,
It is atoleine, liquid petrolatum, isopropyl myristate, isopropyl palmitate, palmitic acid 2- ethylhexyls, oleic acid palmitic acid, hard
The mixture of the one or more such as resin acid, behenic acid, linoleic acid, 16/18 alcohol, Polyquaternium-10.
7. a kind of acne-removing composition as claimed in claim 6, it is characterised in that：The skin conditioning agent includes allantoin, 16/
18 alcohol, Polyquaternium-10 are according to weight ratio (0.1-1):(1-5):(0.1-0.5) is formed.
8. a kind of acne-removing composition as described in claim 1, it is characterised in that：The moisturizer is glycerine, vaseline, palm fibre
Palmitic acid isopropyl propionate, dimethyl silicone polymer are according to weight part ratio (2-10)：(2-5)：(1-5):(1-5) is compounded.
9. a kind of acne-removing composition as described in claim 1, it is characterised in that：The emulsifier is cetyl trimethyl chlorine
Change ammonium, docosyl alcohol and arachidic alcohol glucoside, polyethylene glycol (100) stearate and tristerin are according to weight ratio (0.1-
1):(1-5):(0.5-2) is compounded.
10. a kind of acne-removing composition as described in claim 1, it is characterised in that：Preservative dosage is further included as 0.2-1%,
The preservative selects methyl hydroxybenzoate：Propylben：Phenoxyethanol/methylisothiazolinone is (0.5- by weight
2):(0.5-2):(2-5) is compounded.
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| CN109288744A (en) * | 2018-08-23 | 2019-02-01 | 佛山市洵腾科技有限公司 | A kind of oil-control suppression acne lotion and preparation method thereof |
| CN109846726A (en) * | 2018-10-10 | 2019-06-07 | 广州雷诺生物科技有限公司 | A kind of fullerene skin activating water and preparation method thereof |
| CN109106613B (en) * | 2018-10-18 | 2021-05-04 | 云南民族大学 | Preparation method of mask containing moringa oil and hawthorn polysaccharide |
| CN109330947A (en) * | 2018-12-03 | 2019-02-15 | 陈洁珍 | A kind of oil control and acne removal toner and preparation method thereof |
| CN110876686A (en) * | 2019-11-22 | 2020-03-13 | 广州柏俐臣化妆品科技有限公司 | Repairing composition and preparation method thereof |
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