CN108186679B

CN108186679B - Acne removing composition

Info

Publication number: CN108186679B
Application number: CN201810124686.3A
Authority: CN
Inventors: 王春儒; 李慧; 李岩淞; 陈相龙
Original assignee: Beijing Fullcan Biotechnology Co ltd; Institute of Chemistry CAS
Current assignee: Chifeng Funakang Biotechnology Co ltd; Suzhou Rensheng Zefa Biotechnology Co ltd
Priority date: 2018-02-07
Filing date: 2018-02-07
Publication date: 2020-08-04
Anticipated expiration: 2038-02-07
Also published as: CN108186679A

Abstract

The invention discloses an acne-removing composition which is prepared from the following raw materials in percentage by weight: the composition contains active component containing fullerene 1-5%, emulsifier 1-5%, skin conditioner 1-5%, humectant 5-20%, and water in balance, and has effects of eliminating acne, relieving pain, relieving itching, and repairing scar.

Description

Acne removing composition

Technical Field

The invention relates to the field of acne removal, and in particular relates to an acne removal composition product formula containing fullerene.

Background

Acne and pox are caused by a variety of causes, presumably including hypersecretion of the sebaceous glands; 2. the keratinocyte is dissimilated; 3, growth of propionibacterium acnes; 4. inflammatory reaction. The skin injury is divided into four stages of acne, pimple, nodule and cyst according to the severity. Acne is clinically classified into three degrees and 4 grades according to the nature and severity of skin lesions. Acne only grade 1 (mild); grade 2 (moderate), with some inflammatory papules in addition to the acne; grade 3 (moderate) has more inflammatory papules and/or pustules besides acne, grade 4 (severe) has harmful nodules and cysts besides acne and inflammatory papular pustules. The prior art is directed to treatment primarily for the reasons of formation.

1. The hormone secretion disorder regulates hormone secretion disorder in vivo, estradiol decreases or testosterone increases, resulting in an increase in testosterone/estradiol values in the skin and a relative increase in testosterone values, while specific reductases, in particular 5 α -reductase and 3 β, 17 β -hydroxysteroid dehydrogenase, are present in hair follicles and sebaceous gland cells, which convert testosterone in androgens into dihydrotestosterone which in turn binds to receptors in the sebaceous gland cells and stimulates the proliferation and secretion of sebaceous gland cells, and further, by promoting the synthesis of nucleoprotein in skin cells and the glycolytic pathway for the energy required for lipid synthesis, stimulating the acceleration of the sebaceous gland cell cycle and lipid synthesis, acne is mainly caused by abnormal sebum secretion due to abnormal secretion caused by abnormal secretion of androgens, one way of reducing the condition is to increase regulation of hormones, norgestimate estradiol is a low-dose oral contraceptive approved by the FDA (food and drug administration) for the treatment of acne, the side effects of oral contraceptives are evident as side effects, pain, estradiol decrease or testosterone increase, the anti-ketosis effect of androgen receptor-reductase, such as anti-headache-allergic anti-acne-5, anti-allergic agents, especially anti-allergic agents, such as anti-5-ketosis-reductase, anti-ketosis, anti-acne, anti-5, anti-ketosis, anti-acne, anti-5, anti-ketosis, anti-acne, anti-ketosis, anti-p, anti-p-.

2. For keratinization reduction

The keratinocyte of the basal layer and the follicular keratinocyte are abnormally differentiated, the abnormality can cause the linoleic acid in sebum to be reduced, the linoleic acid is essential fatty acid for the growth of follicular epithelial cells, the linoleic acid is lack of the linoleic acid, the keratinocyte can be densified, the epithelial cell layer of a sebaceous gland duct is continuously thickened, the pipe diameter is reduced, the patency is weakened, and finally the follicular epithelial duct is acutely occluded, and the follicular duct is uplifted to form acne, the keratolysis can thicken and improve the horny layer, remove mature acne, inhibit the micro acne and improve the penetrability of other combined anti-acne medicaments, for example, the retinoic acid has keratolysis effect, can prevent relapse and maintain the acne remission state, has moderate anti-inflammatory effect, can treat inflammatory skin loss, and the new keratinocyte removal medicament has the found side effect of excessive keratinization, or the dosage can cause some damage to the skin and other tissue effects.

3. Antimicrobial and anti-inflammatory

In addition, the biomembrane of the bacteria is composed of extracellular polysaccharide, and the polysaccharide calcium frame polymer can form a protective outer skeleton to play a role of physical barrier and influence and prevent the treatment effect of various effective antibacterial drugs in the microenvironment of the biomembrane. The physical means such as blue-red light irradiation and the like are applied, the propionibacterium acnes can be destroyed and the inflammatory reaction can be reduced through the photodynamics, and the light treatment method has better curative effect on the acnes and can avoid the potential radioactive hazard of the UV method.

4. Scar removing method

After acne is cured, scars formed by damaging skin when inflammation occurs are not eliminated, and the plant active raw materials commonly used for repairing acne skin damage and effectively preventing dark spots at present comprise SOD (super oxide dis mutase superoxide dismutase), liriopeside, alkannin, hypocrellin A, forskolin, luffa saponin, centella asiatica extract and the like.

The composition for treating acne disclosed in patent CN201410086670 comprises one or more of salicylic acid, pentanediol, zinc pyrrolidone carboxylate, sebacic glycol and allantoin, and the composition mainly exerts the effects of removing keratin and acne through salicylic acid, and is added with allantoin to promote cell production, accelerate wound healing and soften keratin. However, the salicylic acid used in the patent has a keratolytic effect like tretinoin, can not only prevent recurrence but also maintain an acne remission state, but also has excessive keratinization, or causes a certain degree of damage to the skin due to the size of the dose, and has an influence on other tissues, and the pain and itch feeling of a patient is not reduced, and pockmarks are not solved. CN201410386421 discloses a mild and effective acne-removing and oil-controlling composition, which comprises sodium hyaluronate, glycerin, propylene glycol, hydroxyethyl cellulose, urea sac, D-panthenol, tao tuoho pine extract, ethanol, white willow bark extract, purslane extract, and the like. The oil-controlling and acne-removing cream is mainly used for achieving the effects of controlling oil and removing acnes by improving the moisturizing effect of skin, regulating the oil-ester balance of the skin, inhibiting the excessive secretion of sebum and inhibiting the reproduction of propionibacterium acnes. The patent shows poor treatment effect on moderate and severe acne, especially poor recovery effect on scars. CN201510449840 discloses a skin repairing agent containing fullerene water-soluble derivatives, which comprises fullerene water-soluble derivatives, iodine, an iodine stabilizer, an iodine complexing agent, allantoin and the like, wherein the skin repairing agent containing fullerene water-soluble derivatives is matched with a skin repairing agent which takes the fullerene water-soluble derivatives as main components, a strong bactericide iodine complexing agent and an allantoin gel preparation containing moisturizing components for use, so that the skin repairing agent can effectively kill bacteria on a wound surface on the surface of damaged skin, promote the repair and regeneration of damaged cells, obviously improve symptoms such as pruritus and the like, and has no effect of repairing pockmarks left by aiming at pockmarks or acnes.

In conclusion, the side effects of anti-inflammatory components such as androgen drugs and antibiotics are large, the anti-inflammatory components are not suitable for long-term use, or the treatment of acne caused by one mechanism is limited in application and low in cure rate. The acne removing product in the prior art can only solve the problem of acne removal, the residual acne marks are a more delicate problem, and meanwhile, the pain and itch feeling during acne growing can also reduce the life quality of patients and cannot be improved. Therefore, a product which can be used for treating acne and pockmark in multiple angles and can improve pain of patients is urgently needed at present.

Disclosure of Invention

In order to solve the technical problems, the invention aims to provide an acne removing composition, the main active ingredients are fullerene and allantoin which are compatible and synergistic to exert curative effects, the composition can effectively remove acne, whelk, physiological stage acne and acne caused by endocrine dyscrasia, and can quickly relieve pain and itch feeling in the acne growing stage, and no pockmark is left after acne removal.

The invention is realized by the following technical scheme:

an acne-removing composition is prepared from the following raw materials in percentage by weight:

1-5% of active component containing fullerene, 1-5% of emulsifier, 1-5% of skin conditioner, 5-20% of humectant and the balance of water.

Further preferably, the acne removing composition is prepared from the following raw materials in percentage by weight:

2-4% of active component containing fullerene, 2-4% of emulsifier, 2-4% of skin conditioner, 8-15% of humectant and the balance of water.

3.6 percent of active component containing fullerene, 3.25 percent of emulsifier, 3.8 percent of skin conditioner, 12 percent of humectant and the balance of water.

The fullerene-containing active ingredient of the present invention is a composition of a fullerene powder, an aqueous fullerene or an oily fullerene and a vegetable oil ester. The fullerene powder, the water-soluble fullerene or the oily fullerene and the vegetable oil ester are composed according to the weight ratio of (3-8) to (0.2-1.5). More preferably, the fullerene powder, the water-soluble fullerene or the oily fullerene and the vegetable oil ester are composed according to the weight ratio of (4-6) to (0.5-1). Preferably, the fullerene powder, the water-soluble fullerene or the oily fullerene and the vegetable oil ester are mixed according to the weight ratio of 5: 1.

In the above technical scheme, the fullerene is a hollow fullerene and/or a metal fullerene. Including but not limited to fullerene C_2n、M@C_2n、M₂@C_2n、MA@C_2n、M₃N@C_2n、M₂C₂@C_2n、M₂S@C_2n、M₂O@C_2nAnd M_xA_3-xN@C_2nAny one of (1), wherein M and A are both metal elements, and both M and A are selected from any one of Sc, Y and lanthanide metal elements; n is more than or equal to 30 and less than or equal to 60; x is more than or equal to 0 and less than or equal to 3.

More preferably, the fullerene is selected from the group consisting of C₆₀、C₇₀、C₇₆、C₈₄，Gd@C₈₂，SC₃N@C₈₀One or more than one of the components.

The vegetable oil esters include, but are not limited to, extracts of plant seeds, flowers, rhizomes, etc., such as olive oil ester, soybean oil ester, linseed oil ester, prinsepia utilis royle oil ester, rapeseed oil ester, sweet almond oil ester, sunflower oil ester, safflower oil ester, grapeseed oil ester, evening primrose oil ester, borage oil ester, angelica oil ester, ginger oil ester, jojoba oil ester, walnut oil ester, avocado oil ester, mango oil ester, castor oil ester, almond oil ester, shea oil ester, rose oil ester, coconut oil ester, lavender oil ester, palm oil ester, millet bran oil ester, wheat germ oil ester, calendula oil ester, aloe oil ester, palm oil ester, argan oil ester, sweet almond oil ester, corn oil ester, and the like, or a mixture of one or more thereof. Further preferably selecting one of grape seed oil ester, ginger oil ester, jojoba oil ester and lavender oil ester; and most preferably jojoba oil ester.

The fullerene in the formula has the effect of treating acne, and particularly has an obvious effect of recovering scars, but due to the hydrophobicity of the fullerene, the absorption is slow, and the bioactivity effect is low. According to the invention, the fullerene can be dispersed into the vegetable oil ester by compounding with the vegetable oil ester, so that the absorption of the fullerene can be promoted, the bioavailability is improved, and meanwhile, the vegetable oil ester also has the function of cooperating the fullerene to remove acnes. In particular, the inventor finds that the fullerene is compatible with the skin conditioner, the humectant, the emulsifier and other auxiliary materials of the invention to promote the absorption of the fullerene and generate the synergistic effect of treating the acne.

The aqueous fullerene and the oily fullerene are prepared by the prior art. Can be prepared according to WO2013/0251/80A1, CN201210406707A and the like.

The skin conditioning agent of the present invention includes but is not limited to allantoin, liquid paraffin, liquid petrolatum, isopropyl myristate, isopropyl palmitate, 2-ethylhexyl palmitate, unsaturated fatty acids such as oleic palmitic acid, stearic acid, behenic acid, linoleic acid, 16/18 alcohol, polyquaternium-10 (PQ400), and one or more mixtures thereof. Further preferably, the skin conditioning agent comprises allantoin, 16/18 alcohol, polyquaternium-10 (PQ400) at a weight ratio of 0.1-1:1-5: 0.1-0.5. More preferably, the skin conditioning agent comprises allantoin, 16/18 alcohol, polyquaternium-10 (PQ400) in a weight ratio of 0.5:3: 0.3.

The allantoin of the invention can directly act on keratin, so that the water binding capacity of the keratin is enhanced, cutin is promoted to relax and soften the keratin, cell growth is promoted, wound healing is accelerated, and the allantoin plays an auxiliary role in treating acne by fullerene. Allantoin according to the present invention is available under the trade name 5-uroethyllactam.

The 16/18 alcohol has skin moistening effect, has good touch feeling, and can make skin smooth, soft and smooth after being applied.

The polyquaternium-10 in the skin conditioner. Polyquaternium-10 (PQ400), the Chinese name is chloro-2-hydroxy-3- (trimethylamino) propyl polyethylene oxide cellulose ether, CAS number is 68610-92-4. As the polyquaternium-10 solution volatilizes along with the moisture, the polyquaternium-10 forms a net structure due to the interaction between molecules, a film is formed, a certain moisture can be kept, and meanwhile, the film-forming property can quickly absorb the moisture. The polyquaternium-10 is used for excellent after-feel of skin, improving the ultraviolet resistance of the skin, and has excellent moisturizing and moistening performances and anti-washing capacity.

The skin conditioner selected and proportioned by the invention can well cooperate with the fullerene active ingredient to treat acne, and play a role in enhancing the elimination and improvement of scars, so that the skin is smooth and fine, and has excellent spreadability, lubricity, moistening type, moisture retention and air permeability.

The humectant is one or more of glycerin, butanediol, polyethylene glycol, propylene glycol, hexanediol, xylitol, polypropylene glycol, sorbitol, IPP, vaseline, polydimethylsiloxane and sodium hyaluronate.

Further preferably, the humectant is compounded by glycerol, vaseline, isopropyl palmitate and polydimethylsiloxane according to the weight ratio of (2-10) to (2-5) to (1-5).

Further preferably, the humectant is compounded by 4-6 parts by weight of glycerin, 2-4 parts by weight of vaseline, 1-3 parts by weight of isopropyl palmitate and 1-3 parts by weight of polydimethylsiloxane.

More preferably, the humectant is prepared by compounding glycerol, vaseline, isopropyl palmitate and polydimethylsiloxane according to the weight ratio of 5:3:2: 2.

The invention relates to a moisturizer, and the inventor finds that a large amount of small molecular moisturizers such as glycerin, propylene glycol, butylene glycol and the like are commonly used, the molecules of the small molecular moisturizers have hydroxyl groups, and after the moisturizer is used on skin, the moisture in a skin care product can be held and kept on the skin by relying on hydrogen bonds. Such a small molecule humectant has a small molecular weight and a high permeability, and easily enters into the interstitial space of keratinocytes, but when the amount of the small molecule humectant added exceeds 8%, irritation is caused, and particularly when ingredients such as fats and oils and emulsifiers are contained in cosmetics, a large amount of small molecule ingredients such as glycerin is required to be added for enhancing moisture retention, but irritation is increased. In order to avoid strong irritation, isopropyl palmitate is added into the moisturizing agent composition disclosed by the invention to play a role in moisturizing and nourishing the skin, so that the product has good absorbability to the skin, can effectively contact hair follicles in the cortex and penetrate into the deep part of the cortex, and brings active components in cosmetics into the skin to fully play the role of active ingredients. The Vaseline and the polydimethylsiloxane have smooth skin feeling. The humectant provided by the invention can better coordinate the moisturizing effect with the film-forming property of polyquaternium in the skin conditioner.

The emulsifier of the invention is preferably one or more of hexadecyl trimethyl ammonium chloride (1631), behenyl alcohol and arachidyl alcohol glucoside (CS200), polyethylene glycol (100) stearate and glyceryl stearate (E165), stearic acid, sorbitan sesquioleate, polyethylene glycol-30, hexadecyl trimethyl ammonium chloride, dipolyhydroxystearate, lecithin and magnesium stearate. Further preferably, cetyl trimethyl ammonium chloride, behenyl alcohol, arachidyl alcohol glucoside, polyethylene glycol (100) stearate and glyceryl stearate are compounded according to the weight ratio of (0.1-1) to (1-5) to (0.5-2). Further preferably, cetyl trimethyl ammonium chloride, behenyl alcohol and arachidyl alcohol glucoside, polyethylene glycol (100) stearate and glyceryl stearate are compounded according to the weight ratio of 0.25:2: 1. The emulsifier is compounded to make the ointment fine and beautiful and the using effect is optimal. Wherein, the hexadecyl trimethyl ammonium chloride has good stability and anti-flocculant.

As ingredients that can be blended, preservatives, fragrances, and the like may also be added to the composition of the present invention.

The preservatives are preferably added to the composition in an amount of 0.2 to 1%, preferably 0.5 to 0.8%. The preservative comprises a water-soluble preservative and an oily preservative. Preferably selecting more than one of methyl paraben, propyl paraben, phenoxyethanol, ethylhexyl glycerol and tert-butyl hydroquinone. In order to achieve a better antiseptic and bactericidal effect, the use of an antiseptic agent often seriously exceeds the safe use dosage, thereby bringing about potential safety hazards. Further preferably, the preservative is selected from methyl paraben: propyl p-hydroxybenzoate: the phenoxyl ethanol/methylisothiazolinone is compounded according to the weight ratio of (0.5-2) to (2-5). Further preferably, the preservative is selected from methyl paraben: propyl p-hydroxybenzoate: the phenoxyethanol/methylisothiazolinone is compounded according to the weight ratio of 1.2:1: 4. The compounded preservative system has a synergistic antibacterial effect, can still maintain sufficient bactericidal capacity by composite use on the premise of reducing respective safe and effective use amount, and is safe and free of side effects. Can also avoid secondary pollution, especially the sterilization effect on mould, prolong the shelf life of the product and ensure the product quality.

The dosage of the aromatic is 0.01-0.05%.

All of the moisturizers, skin conditioners, emulsifiers, preservatives, fragrances, actives of the present invention are commercially available.

Advantageous effects

1. The acne-removing composition prepared by scientifically proportioning, modulating and preparing the active ingredients and the auxiliary materials has the effects of removing acnes, relieving pain and itching and repairing scars. The acne-removing composition provided by the invention has an obvious acne-removing effect, can effectively remove acne, whelk in a physiological period and whelk caused by endocrine dyscrasia, can quickly relieve pain and itch feeling in a whelk-growing period, and does not leave marks after acne removal.

2. The composition of the invention is very easy to permeate the stratum corneum of the skin, is easier to absorb and utilize, and has more easily exerted efficacy.

3. The composition has the best curative effect on moderate and severe acne patients, has high curative rate and does not relapse. The acne cream can eliminate the red and swollen acne in a very short time, relieve the pain and itch symptoms, quickly eliminate the acne, and leave no trace after the acne is removed by using the product.

4. The composition has the advantages of small irritation, no side effect and long-term use.

5. The composition is stable, convenient to store, and free of layering and flocculation in high and low temperature environments.

6. The composition of the invention is fine, mild, strong in skin-sticking property, and easy to be smeared and absorbed.

7. The compounded anticorrosive system of the formula has broad-spectrum antibacterial property, and the compounded anticorrosive system has small dosage and improved safety.

Drawings

FIG. 1 is a process flow diagram of a composition according to the present invention.

Fig. 2A-2C are graphs of the effect of the product according to the invention before and after trial use, fig. 2A being before use, fig. 2B being the day after use, and fig. 2C being after 1 week of use.

Detailed Description

The following detailed description of specific embodiments of the invention is provided, but it should be understood that the scope of the invention is not limited to the specific embodiments.

Table 1 examples 1-5

The preparation process comprises the following steps: adding the weighed A-phase raw materials into a water phase pot, stirring and heating to 85 ℃, adding the C-phase raw materials after uniformly stirring, and adding the weighed B-phase raw materials into an oil phase pot to be completely dissolved at 85 ℃. Preheating the emulsifying pot to 60-70 deg.C, vacuumizing, sucking water phase and oil phase, homogenizing (4000r/min), stirring, cooling to 45 deg.C, adding D, E, stirring, and discharging. And filling the semi-finished product after the semi-finished product is inspected to be qualified, and warehousing the finished product after the finished product is inspected to be qualified.

Table 2 examples 6 to 10

Test example-acne removing Effect test

Medicine preparation: the acne-removing composition of example 1 was taken,

experimental groups: 20 adolescent male A groups and 20 adolescent female B groups are selected for testing, and the 40 subjects are 14-24 years old and are mostly acne caused by hormone or endocrine dyscrasia. Selecting 30 women with the age of 35-45 years C in the physiological near-physiological period, wherein the 30 women have habitual menstrual period long pox, and the pox can form shallow spots after the elimination of the pox after the menstrual period. The working group of 30-40 years old, 20D groups for men and 20E groups for women are selected, and the situation of acne growing frequently occurs because the life and work are irregular and the working is often carried out overnight. During the trial of the product, all diet and living habits were used as usual from the time when each pox just emerged and recorded as the first day.

The using method comprises the following steps: topically applying to acne or acne mark, and gently massaging for absorption

As a result: as shown in the table 3 and the attached figure 2, the experimental results of the population with the acne at different ages and for different reasons show that the acne can be eliminated in the next day in a very short time, the pain and itch symptoms can be relieved, the acne can be eliminated quickly, and no trace is left after the acne is grown.

TABLE 3

As can be seen from Table 3, the composition of the present invention is most effective for the people who frequently grow pox, especially for the improvement of pox mark.

Test example two, the synergistic effect of the acne-removing composition of the invention

Selecting 40 acne patients by blind test, performing experiment in groups, wherein each group of test subjects comprises 10, and the following products with different proportions are respectively tried out and shown in Table 4

Comparative group 1: example 1 free of jojoba oil ester

Comparative group 2: example 1 contains no allantoin

TABLE 4 synergistic effect of the compositions of the invention

As can be seen from Table 4, the composition containing vegetable oil ester has a stronger acne removing effect than the composition containing no vegetable oil ester and no allantoin, the vegetable oil ester and fullerene have a synergistic effect, and the allantoin can promote the scar repairing effect of the composition. As can be seen from the data for examples 1-3 and example 6, the selection of the components for examples 1-3 works better than example 6. As can be seen from the data of examples 1-3, the formulation of example 1 works best.

The above effects are exhibited by the compositions of all the examples of the present invention and the scope of the claims.

Test example three selection test of anticorrosive system

According to the American cosmetic, toiletries and perfume Association (CTFA method). Weighing 100g of products with different antiseptic systems, respectively adding into a sterilized container, respectively adding 1ml of Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Candida albicans, and Aspergillus niger, and shaking. Samples were taken on days 0, 7, 14, 21, and 28 of inoculation for analysis. If the amount of viable bacteria is below 100CFU/g 7 days after the addition of bacteria, the total amount drops to 0 within 28 days, which is regarded as excellent, and passes the challenge. If the viable bacterial count is below 1000 at 7 days, it is deemed marginal to pass, and if the viable bacterial count is above 1000 at 7 days, it is deemed to have failed the preservative challenge. The results are shown in Table 5

TABLE 5

The foregoing descriptions of specific exemplary embodiments of the present invention have been presented for purposes of illustration and description. It is not intended to limit the invention to the precise form disclosed, and obviously many modifications and variations are possible in light of the above teaching. The exemplary embodiments were chosen and described in order to explain certain principles of the invention and its practical application to enable one skilled in the art to make and use various exemplary embodiments of the invention and various alternatives and modifications as are suited to the particular use contemplated. It is intended that the scope of the invention be defined by the claims and their equivalents.

Claims

1. The acne-removing composition is characterized by comprising the following raw materials in percentage by weight: 1-5% of active component containing fullerene, 1-5% of emulsifier, 1-5% of skin conditioner, 5-20% of humectant and the balance of water; the active component containing fullerene is a composition of fullerene powder and vegetable oil and fat, and the composition consists of the fullerene powder and the vegetable oil and fat according to the weight ratio of (3-8) to (0.2-1.5); the skin conditioner comprises allantoin, 16/18 alcohol and polyquaternium-10 according to the weight ratio of (0.1-1) to (1-5) to (0.1-0.5).

2. The acne-removing composition according to claim 1, which is prepared from the following raw materials in percentage by weight: 2-4% of active component containing fullerene, 2-4% of emulsifier, 2-4% of skin conditioner, 8-15% of humectant and the balance of water.

3. The acne-removing composition according to claim 1, which is prepared from the following raw materials in percentage by weight: 3.6 percent of active component containing fullerene, 3.25 percent of emulsifier, 3.8 percent of skin conditioner, 12 percent of humectant and the balance of water.

4. An anti-acne composition according to any of claims 1 to 3, characterized in that: the fullerene powder and the vegetable oil are composed according to the weight ratio of (4-6) to (0.5-1).

5. The acne treatment composition according to claim 4, wherein: the fullerene powder and the vegetable oil are composed according to the weight ratio of 5: 1.

6. The acne-removing composition according to claim 1, wherein: the vegetable oil is one or a mixture of more of olive oil, soybean oil, linseed oil, prinsepia utilis royle oil, rapeseed oil, sweet almond oil, sunflower oil, safflower seed oil, grape seed oil, evening primrose oil, borage seed oil, angelica oil, ginger oil, jojoba oil, walnut oil, avocado oil, mango oil, castor oil, almond oil, shea butter, rosehip oil, coconut oil, lavender oil, palm oil, bran oil, wheat germ oil, calendula oil, aloe oil, diglyceride and corn oil.

7. The acne treatment composition according to claim 6, wherein: the vegetable oil is jojoba oil.

8. The acne-removing composition according to claim 1, wherein: the skin conditioning agent comprises allantoin, 16/18 alcohol and polyquaternium-10 according to the weight ratio of 0.5:3: 0.3.

9. The acne-removing composition according to claim 1, wherein: the humectant is prepared from glycerol, vaseline, isopropyl palmitate and polydimethylsiloxane according to the weight part ratio of (2-10): (2-5): (1-5) and (1-5) are compounded.

10. The acne treatment composition according to claim 9, wherein: the humectant is compounded by 4-6 parts by weight of glycerin, 2-4 parts by weight of vaseline, 1-3 parts by weight of isopropyl palmitate and 1-3 parts by weight of polydimethylsiloxane.

11. The acne treatment composition according to claim 10, wherein: the humectant is compounded by glycerin, vaseline, isopropyl palmitate and polydimethylsiloxane according to the weight ratio of 5:3:2: 2.

12. The acne-removing composition according to claim 1, wherein: the emulsifier is compounded by cetyl trimethyl ammonium chloride, behenyl alcohol, arachidyl alcohol glucoside, polyethylene glycol (100) stearate and glyceryl stearate according to the weight ratio of (0.1-1) to (1-5) to (0.5-2).

13. The acne treatment composition of claim 12 wherein: the emulsifier is compounded by cetyl trimethyl ammonium chloride, behenyl alcohol, arachidyl alcohol glucoside, polyethylene glycol (100) stearate and glyceryl stearate according to the weight ratio of 0.25:2: 1.

14. An acne-removing composition is characterized in that: the material is prepared from the following raw materials in percentage by weight: 1-5% of active ingredient containing fullerene, 1-5% of emulsifier, 1-5% of skin conditioner, 5-20% of humectant, 0.2-1% of preservative and the balance of water, wherein the preservative is methyl paraben: propyl p-hydroxybenzoate: the phenoxyethanol/methylisothiazolinone is compounded according to the weight portion ratio of (0.5-2) to (2-5); the active component containing fullerene is a composition of fullerene powder and vegetable oil and fat, and the composition consists of the fullerene powder and the vegetable oil and fat according to the weight ratio of (3-8) to (0.2-1.5); the skin conditioner comprises allantoin, 16/18 alcohol and polyquaternium-10 according to the weight ratio of (0.1-1) to (1-5) to (0.1-0.5).

15. An acne-removing composition is characterized in that: the material is prepared from the following raw materials in percentage by weight: 1-5% of active component containing fullerene, 1-5% of emulsifier, 1-5% of skin conditioner, 5-20% of humectant, 0.2-1% of preservative, 0.01-0.05% of aromatic and the balance of water; the active component containing fullerene is a composition of fullerene powder and vegetable oil and fat, and the composition consists of the fullerene powder and the vegetable oil and fat according to the weight ratio of (3-8) to (0.2-1.5); the skin conditioner comprises allantoin, 16/18 alcohol and polyquaternium-10 according to the weight ratio of (0.1-1) to (1-5) to (0.1-0.5).

16. Use of the composition according to claim 1 for the preparation of a medicament for the treatment of acne, pain relief, itching relief, scar repair.