KR102203168B1 - Method for production of o/w gel cream with high content of ethanol - Google Patents

Abstract

The present invention relates to a method for producing an oil-in-water type emulsified gel cream, which stabilizes high content ethanol with a stable oil-in-water type emulsion and protects the skin barrier. The oil-in-water emulsified gel cream of the present invention contains a high content of ethanol to form a moisturizing barrier and prevent dry skin while maintaining the antibacterial and disinfecting effect which is a basic function, thereby reducing skin irritation and providing a moist and soft feeling.

Description

Method for producing oil-in-water emulsion gel cream containing high ethanol {Method for production of o/w gel cream with high content of ethanol}

The present invention relates to a method for producing an oil-in-water emulsion gel cream containing high ethanol, and more specifically, stabilizes high content ethanol as an oil-in-water emulsion, relieves irritation of ethanol, and moisturizes and skin with antibacterial and disinfecting effects. It relates to a method for producing an oil-in-water emulsion gel cream containing high ethanol that has a function of protecting a barrier.

Until now, conventional disinfectants include a spray type with an ethanol content of 62% or more, or a transparent low viscosity liquid, and have been used as a simple function to disinfect microorganisms such as bacteria and viruses. However, as the corona-19 virus is popular around the world, many cleansing products in the form of hand cleaners or hand gels are also being released in the cosmetic industry.

However, these products are obsessed with the simple basic function of imparting disinfecting effects by destroying the underlying proteins of bacteria. As a result, alcohol allergy occurs in people with weak or sensitive skin, and it causes severe dryness and rough skin, resulting in a side effect of rapidly aging.

Therefore, there is a need to develop an ethanol-based disinfectant or a cosmetic formulation for skin disinfection that can solve the above problems.

Korean Patent Registration No. 10-1792239 discloses an antibacterial composition comprising 7,10-epoxyoctadeca-7,9-dienoic acid and antibiotics as active ingredients. Korean Patent Registration No. 10-0967832 discloses an antimicrobial composition containing a leaf extract and lotus root extract as active ingredients. Korean Patent Registration No. 10-0947282 discloses a disinfectant composition that has aloe vera gel as a main component and can be used at any time without being restricted to a place since there is no need to wash with water by adding vinegar and complex golden extract. Korean Patent Registration No. 10-1467698 discloses an antimicrobial composition comprising a Baekshou extract. In the Republic of Korea Patent Registration 10-1800697, by including chitosan, calendula flower extract, licorice extract, magnolia flower extract and lotus flower extract, a cosmetic composition having excellent effects such as skin aging inhibition, elasticity improvement, and moisturizing due to antioxidant is described.

In the present invention, a method of manufacturing an emulsified gel cream containing a high content of ethanol to prevent skin dryness and to form a moisturizing barrier while maintaining the basic function of antibacterial and disinfecting effect, reducing skin irritation, and providing a moist and soft touch. We intend to develop and provide it.

The present invention comprises the steps of preparing an aqueous phase by dispersing and dissolving Carbomer or Xanthan Gum in an aqueous mixture containing purified water (a); Step of preparing an oil phase by adding and dissolving polyglyceryl-10 isostearate and polyglyceryl-10 oleate, which are surfactants, to a fat-soluble mixture containing oil (b ); (C) inducing an emulsification reaction by mixing and stirring the aqueous phase prepared in step (a) and the oil phase prepared in step (b); After step (c), adding a neutralizing agent to adjust the pH to 5.5 to 7.5 (d); It provides a method for producing an oil-in-water emulsion gel cream containing ethanol, comprising: (e) adding ethanol after the step (d).

In the production method of the ethanol-containing oil-in-water emulsion gel cream of the present invention, the method for preparing the oil-in-water emulsion gel cream is preferably, after step (e), adding an additive including a moisturizing agent and a sedative ( f); may further include.

In the method for producing an oil-in-water emulsion gel cream containing ethanol of the present invention, the aqueous mixture containing purified water is preferably glycerin, dipropylene glycol, 1,2-hexanediol (1, 2-Hexanediol) and purified water may be mixed.

In the manufacturing method of the ethanol-containing oil-in-water emulsion gel cream of the present invention, the oil-soluble mixture containing the oil is preferably canola oil or rapeseed oil, grape seed oil, apricot seed oil, peppermint oil, macadamia seed oil (Macadamia Ternifolia Seed Oil), argan kernel oil (Argania Spinosa Kernel Oil), and Shea butter (Shea Butter) may be mixed.

In the method for producing an ethanol-containing oil-in-water emulsion gel cream of the present invention, the surfactant may preferably further include cetearyl alcohol as a stabilizer.

In the method for producing an ethanol-containing oil-in-water emulsion gel cream of the present invention, the neutralizing agent may be preferably arginine or triethanolamine.

In the manufacturing method of the ethanol-containing oil-in-water emulsion gel cream of the present invention, the additive may be preferably any one or more selected from sodium hyaluronate and allantoin.

The oil-in-water emulsion gel cream of the present invention contains a high content of ethanol and maintains the basic function of antibacterial and disinfecting effect, while preventing skin dryness and forming a moisturizing barrier, reducing skin irritation, and providing a moist and soft texture. to provide.

1 is a schematic diagram illustrating a process in which various bacteria are sterilized by applying the oil-in-water emulsion gel cream of the present invention to the skin.
Figure 2 is a schematic diagram illustrating the mechanism by which the oil-in-water emulsion gel cream of the present invention acts on the skin.
Figure 3 is a flow chart showing a method of manufacturing the present invention oil-in-water emulsion gel cream.
Figure 4 is a schematic diagram showing an easy-to-understand emulsification mechanism for forming an oil-in-water emulsion cream gel in the present invention
5 is a photograph of the oil-in-water emulsion gel cream of Example 1 observed with an optical microscope.
6 is a graph measuring the particles of the oil-in-water emulsion gel cream of Example 1.
7 is a photograph of a finished product prepared with an oil-in-water emulsion gel cream of Example 1.
8 is a photograph of a finished product prepared from the disinfectant gel of Comparative Example 1.
9 is a photograph showing a process of applying and using the oil-in-water emulsion gel cream of Example 1 to the skin.
10 is a graph showing the results of testing the antibacterial effect of the oil-in-water emulsion gel cream of Example 1.
11 is a graph of the results of evaluating the hand disinfection effect of the oil-in-water emulsion gel cream of Example 1.
12 is a graph showing the ethanol allergy reduction effect of the oil-in-water emulsion gel cream of Example 1.
13 is a graph of the results of evaluating the effect of improving the dry skin condition of the oil-in-water emulsion gel cream of Example 1.
14 is a graph showing the skin moisturizing persistence evaluation results of the oil-in-water emulsion gel cream of Example 1.
15 is a graph showing the skin cleansing effect of the oil-in-water emulsion gel cream of Example 1.

In the present invention, it is intended to prepare a cream formulation that contains more than 60% by weight of alcohol and has an antibacterial disinfecting effect, and can improve the induction of severe skin dryness and skin allergies of the disinfectant, and is soft and moist to protect the skin barrier. .

Specifically, first, we tried to develop a manufacturing method for making a stable, milky, oil-in-water type hydrophilic cream gel containing a high content of alcohol, out of the conventional liquid type or simple mixture in the form of a low viscosity gel. Here, the meaning of oil-in-water type means that an emulsified cream gel in which an oil phase is dispersed in an aqueous phase is formed.

Second, the alcohol contained in the oil-in-water hydrophilic cream is volatilized by first disinfecting and sterilizing the contaminants when applied to the skin, and the remaining hydrophilic emulsion is applied softly and moistly to the skin to prevent drying and It was intended to develop a new formulation that eliminates the occurrence of allergies, is absorbed into the skin, and strengthens the skin barrier and moisturizing effect.

Third, when an oil-in-water type hydrophilic cream gel was applied to the skin, the antibacterial disinfecting effect was evaluated, the skin irritation was reduced, and the skin moisturizing power increased.

As shown in Figure 1, the skin structure is divided into an epidermal layer and a dermal layer. In order to disinfect the contaminants of the epidermal layer, when an oil-in-water cream is applied and rubbed, various bacteria and microorganisms present on the skin are killed from ethanol. Conventional disinfectants have a sterilizing effect due to a high content of ethanol, but they weaken the skin barrier, tingling with erythema, and giving off severe alcohol odor. In addition, fragile skin holders may cause allergies, and when used frequently, dry skin may occur. Therefore, it is necessary to develop an oil-in-water type cream that maintains disinfecting power and reinforces a soft, moist feeling and moisturizing power.

However, it is not easy to make an oil-in-water emulsion cream gel containing a high content of ethanol. In a conventional technique, the emulsion particles may be broken under the influence of ethanol contained in an excessive amount, and separation may occur. In particular, it causes severe dryness due to the effect of excessive ethanol, and the skin becomes fragile and eventually aging may worsen rapidly.

However, in the present invention, despite the high content of ethanol, the emulsified particles are not broken, and an oil-in-water type emulsified gel cream that exhibits excellent moisturizing power and a soft feeling of use was prepared. The principle of skin action of the oil-in-water emulsion gel cream developed in the present invention is shown in FIG. 2. When an oil-in-water emulsion gel cream containing a high content of ethanol is applied to the skin, various bacteria present in the skin are sterilized, and the ethanol is volatilized into the air and disappears. After that, the oil-in-water type emulsifying cream remaining on the skin is applied to the skin, and some of it is absorbed and has a beneficial effect on the skin. It provides excellent skin moisturizing action, dryness prevention, and moist feeling to reduce the rejection of ethanol and reduces allergic reactions.

The method for preparing an oil-in-water emulsion gel cream of the present invention comprises the steps of preparing an aqueous phase by dispersing and dissolving carbomer or xanthan gum in an aqueous mixture containing purified water (a); (B) preparing an oil phase by adding and dissolving polyglyceryl-10 isostearate and polyglyceryl-10 oleate, which are surfactants, to a fat-soluble mixture containing oil; (C) inducing an emulsification reaction by mixing and stirring the aqueous phase prepared in step (a) and the oil phase prepared in step (b); After step (c), adding a neutralizing agent to adjust the pH to 5.5 to 7.5 (d); And the step (e) of adding ethanol after the step (d).

Hereinafter, the method of manufacturing the oil-in-water emulsion gel cream of the present invention will be subdivided into each step and described in detail below (see FIG. 3).

<Step (a): manufacturing of the water phase>

This step is a process of preparing an aqueous phase by dispersing and dissolving carbomer or xanthan gum in an aqueous mixture containing purified water. At this time, the water-soluble mixture containing purified water may be preferably a mixture of glycerin, dipropylene glycol, 1,2-hexanediol, and purified water. Specifically, based on the total weight of the oil-in-water emulsion gel cream composition of the present invention, 1 to 3% by weight of glycerin, 2 to 5% by weight of dipropylene glycol, 0.002 to 2% by weight of 1,2-hexanediol , 20 to 30% by weight of purified water may be used, and 0.1 to 0.8% by weight of carbomer or 0.1 to 0.8% by weight of xanthan gum may be used. More specifically, 1 to 3% by weight of glycerin, 2 to 5% by weight of dipropylene glycol, 0.002 to 2% by weight of 1,2-hexanediol, 21 to 27% by weight of purified water are used, and 0.3 ~0.8% by weight of carbomer or 0.1 to 0.5% by weight of xanthan gum may be used individually or in combination.

In this step, the process of dissolving and dispersing carbomer or xanthan gum is preferably performed by heating to 50°C, dissolving transparently, and homogeneously dispersing for 30 minutes to 2 hours at 200-1,500 rpm using a dispermixer. .

<Step (b): Preparation of oil phase>

This step is a process of preparing the oil phase by adding and dissolving polyglyceryl-10 isostearate and polyglyceryl-10 oleate, which are surfactants, to a fat-soluble mixture containing oil. At this time, the oil-soluble mixture containing the oil may be formed by mixing canola oil or rapeseed seed oil, grape seed oil, apricot seed oil, peppermint oil, macadamia seed oil, argan kernel oil, and shea butter. Specifically, based on the total weight of the oil-in-water emulsion gel cream composition of the present invention, 0.1 to 2% by weight of canola oil or rapeseed seed oil, 0.1 to 1% by weight of grape seed oil, 0.1 to 1.5% by weight of apricot seed oil, 0.01 ~1% by weight of peppermint oil, 0.01-1% by weight macadamia seed oil, 0.1-2% by weight argan kernel oil, 0.1-2% by weight of shea butter can be used, and more specifically 0.1-2% by weight Of canola oil or rapeseed oil, 0.1 to 1% by weight grape seed oil, 0.1 to 1.2% by weight apricot seed oil, 0.01 to 0.8% by weight peppermint oil, 0.01 to 1% by weight macadamia seed oil, 0.1 to 2% by weight % Argan kernel oil, 0.1 to 2% by weight of shea butter can be used.

On the other hand, as the surfactant of this step, polyglyceryl-10 isostearate and polyglyceryl-10 oleate are used, in detail, 0.1 to 2 weight based on the total weight of the oil-in-water emulsion gel cream composition of the present invention. % Of polyglyceryl-10 isostearate, 0.1 to 1.5% by weight of polyglyceryl-10 oleate may be used, and more specifically, 0.1 to 1.5% by weight of polyglyceryl-10 isostearate, 0.1 to 1% by weight of polyglyceryl-10 oleate can be used.

In addition, it may be used by adding cetearyl alcohol as a stabilizer preferably to the two surfactants. Specifically, based on the total weight of the oil-in-water emulsion gel cream composition of the present invention, 0.1 to 2% by weight of cetearyl alcohol may be added to polyglyceryl-10 isostearate and polyglyceryl-10 oleate. .

In the process of weighing and dissolving the oil phase in this step, it is important to mix and dissolve the surfactant and the stabilizer well with various oils, and preferably dissolve to 80°C and mix well.

<Step (c): emulsification reaction>

This step is a process of inducing an emulsification reaction by mixing and stirring the aqueous phase part prepared in step (a) and the oil phase part prepared in step (b). This step is a step of performing an emulsification reaction by mixing the aqueous phase and the oil phase. Preferably, the oil phase is stirred for 5 to 15 minutes with a dispermixer at 3,000 to 4,500 rpm for 5 to 15 minutes (0.1 to 10 μm). ) To stabilize the dispersion. At this time, the mixture of polyglyceryl-10 isostearate and polyglyceryl-10 oleate as surfactants plays the most important role in the formation and stability of emulsified particles, and the use of cetearyl alcohol in combination is emulsification. It plays an important role in particle formation and stability.

<Step (d): Neutralization>

This step is a process of adjusting the pH to 5.5 to 7.5 by adding a neutralizing agent after step (c). At this time, the neutralizing agent may be preferably arginine or triethanolamine. Specifically, with respect to the total weight of the oil-in-water emulsion gel cream composition of the present invention, 0.1 to 2% by weight of arginine or 0.1 to 2% by weight of triethanolamine may be used alone or in combination. More specifically, 0.1 to 1.5% by weight of arginine or 0.1 to 1.5% by weight of triethanolamine may be used alone or in combination.

The neutralization process in this step is a process of adjusting the pH to stabilize the carbomer (or xanthan gum) and the emulsified particles. Preferably, the most stable emulsified particles were obtained when the pH was in the range of 5.5 to 7.5.

<Step (e): ethanol addition>

This step is a process of adding ethanol after step (d). Specifically, 58 to 70% by weight of ethanol may be gradually added to the oil-in-water emulsion cream gel based on the total weight of the oil-in-water emulsion gel cream composition to be homogeneously dispersed. More specifically, 60 to 63% by weight of ethanol may be slowly added to an oil-in-water emulsion cream gel to homogeneously disperse.

This step is a process of stably dispersing ethanol in the oil-in-water emulsion obtained by the neutralization reaction of step (d). Dispersion should be performed by slowly adding ethanol while stirring with a disper to make the gel well. Preferably, the stirring speed of the disper is made at 700 ~ 2000rpm, and it is important to refine the oily particles by stirring the homomixer at 1500 ~ 4500rpm for 10 minutes.

<Step (f): Additive (moisturizer, sedative) added>

This step is a process of adding an additive including a moisturizing agent and a soothing agent after step (e). In this case, the additive may be preferably any one or more selected from sodium hyaluronate as a moisturizing agent and allantoin as a sedative agent. Specifically, with respect to the total weight of the oil-in-water emulsion gel cream composition of the present invention, 0.001 to 1% by weight of sodium hyaluronate or 0.01 to 1% by weight of allantoin is added or mixed to reduce the irritation of ethanol. It can be used as a function that gives a moisturizing effect. In more detail, 0.001 to 1% by weight of sodium hyaluronate or 0.01 to 1% by weight of allantoin may be added, respectively, or added in combination. In addition to sodium hyaluronate and allantoin, it can contain ingredients that help improve skin barrier and maintain moisture.

In this step, additives sensitive to temperature and agitation (moisturizer, sedative, protective agent, etc.) are finally added. After passing through this step, vacuum degassing and degassing are performed to complete the final preparation of the ethanol-containing oil-in-water emulsion gel cream of the present invention. The pH of the finished oil-in-water emulsion gel cream containing ethanol of the present invention is in the range of 4.5 to 7.5, the specific gravity is 0.8 to 0.95, the particle size is 0.1 to 20 μm, and the viscosity is a creamy emulsion of 8,000 to 70,000 cps.

4 is a schematic diagram showing an easy-to-understand emulsification mechanism for forming an oil-in-water emulsion cream gel in the present invention. The external wound is composed of the water phase, and the oil particles are stably wetted by surfactants to form micelles, and it is easily expressed that the oil-in-water type cream is stabilized.

Hereinafter, the content of the present invention will be described in more detail through the following examples and experimental examples. However, the scope of the present invention is not limited to the following examples and experimental examples, and includes modifications of equivalent technical ideas.

[Examples 1 to 4: Preparation of oil-in-water emulsion gel cream]

In Examples 1 to 4, a crystal oil emulsion gel cream was prepared according to the composition shown in Table 1 below.

division Ingredient name Example 1
Content (wt%) Example 2
Content (wt%) Example 3
Content (wt%) Example 4
Content (wt%) Award glycerin 3 5 One 3 Dipropylene glycol 2 One 5 3 1,2-hexanediol 0.002 One 0.1 0.2 Purified water 25.647 21.774 25.39 24.499 Carbomer 0.75 0.525 0.5 0.5 Xanthan gum - - 0.2 0.1 Paid part Canola oil or rapeseed oil 1.485 1.5 1.2 1.2 Grape seed oil 0.75 0.8 0.8 0.6 Apricot seed oil 0.6 0.5 0.3 0.6 Peppermint Oil 0.2 0.2 0.1 0.2 Macadamia seed oil 0.15 0.2 0.3 0.2 Argan kernel oil 0.015 0.1 0.1 0.1 Shea Butter One One 0.5 One Cetearyl alcohol One One 0.5 One Polyglyceryl-10 isostearate 0.6 2 One 0.8 Polyglyceryl-10 oleate 0.4 One 0.5 0.5 Neutralization Arginine 0.4 0.4 0.5 0.4 solvent Ethanol (ethyl alcohol) 62 62 62 62 adding Sodium hyaluronate 0.001 0.001 0.01 0.001 Allantoin - - - 0.1 sub Total 100 100 100 100

3 shows a method for producing a stable oil-in-water type emulsion-type cream gel containing a high content of ethanol in the composition described in Table 1 above.

Step 1 (Step a) is a process of dissolving and dispersing carbomer (aqueous part). After dissolving by heating to 50°C and dissolving transparently, a process of homogeneously dispersing for 30 minutes to 2 hours at 1,500 rpm using a dispermixer Was done.

Step 2 (Step b) is a process of weighing and dissolving the oil phase, and it is important to mix and dissolve the surfactant well with various oil phases, and these were dissolved to 80°C and mixed well.

Step 3 (Step c) is a step of performing an emulsification reaction by mixing the aqueous phase and the oil phase. The oil phase was dispersed and stabilized into fine particles in the aqueous phase by stirring for 10 minutes at 1,500 rpm with a dispermixer at 750°C.

In step 4 (step d), a neutralization reaction was performed by mixing arginine. To stabilize the carbomer and emulsified particles, the pH was stably adjusted, and the final pH was in the range of 5.5 to 7.5.

In step 5 (step e), ethanol was stably dispersed in the oil-in-water emulsion obtained by the process in which the neutralization reaction was performed well up to step 4. As for the dispersion conditions, ethanol was slowly added while stirring with a disper to make the gel well. The stirring speed of the disper was made at 1,500rpm, and the homomixer was also stirred at 3,000rpm for 10 minutes to refine the oily particles.

In step 6 (step f), additives sodium hyaluronate (moisturizer) and allantoin (soothing agent) were added and stably dispersed.

After passing through steps 1 to 6 as described above, a degassing process was performed by additional vacuum degassing to complete the final product.

[Comparative Examples 1 to 3: Preparation of alcohol disinfectant]

Comparative Examples 1 to 3 are representative disinfectant products that are conventionally industrialized and were prepared to compare and evaluate the advanced technology and performance of the examples of the present invention.

division Ingredient name Comparative Example 1
Content (wt%) Comparative Example 2
Content (wt%) Comparative Example 3
Content (wt%) One glycerin 3 4 5 2 Aminomethylpropanol 0.1 0.2 0.3 3 Isopropyl myristate 3 3 3 4 Tocopheryl Acetate 0.1 0.1 0.1 5 Propylene glycol 2 2 3 6 Spices 0.1 0.1 0.1 7 Methyl paraoxybenzoate 0.1 0.2 0.3 8 Purified water 29.3 28 25.7 9 Carbomer 0.3 0.4 0.5 10 ethanol 62 62 62 sub Total 100 100 100

The manufacturing method of Comparative Example 1 was described below. After the components 1 to 7 in Table 2 were weighed and dissolved by heating, purified water of component 8 was added to completely dissolve. Thereafter, a process of gelling was performed by adding the carbomer of component 9, and then, ethanol of component 10 was slowly added to stabilize the dispersion. The result was a clear, low viscosity liquid, a disinfectant.

[Examples 5 to 8: Preparation of oil-in-water emulsion gel cream]

Examples 5 to 8 are examples composed mainly of synthetic oil. The surfactant is also an example in which an oil-in-water type emulsion cream gel was prepared using a polyoxyethylene-based petroleum-based surfactant. Preparation was carried out according to the method described in Examples 1 to 4.

division Ingredient name Example 5
Content (wt%) Example 6
Content (wt%) Example 7
Content (wt%) Example 8
Content (wt%) Award glycerin 3 4 One 2 Dipropylene glycol 2 One 3 2 1,3-butylene glycol 2 One 4 One 1,2-hexanediol 0.5 One 1.4 2 Purified water 24.8 22.8 20 21.5 Carbomer 0.3 0.5 0.4 0.3 Hydroxyethyl cellulose 0.1 0.1 0.1 0.1 Paid part Cetylethylhexanoate 1.5 1.5 One One Capric/Caprylic Triglyceride One 0.8 0.5 0.3 Ethylhexyl palmitate 0.2 0.5 0.7 One Hydrogenated Polydecene 0.2 0.1 0.3 0.4 Mineral oil - 0.1 0.3 0.5 Stearic Acid 0.5 One 1.5 2 Cetearyl alcohol 2 One 0.5 0.1 PEG-40 Hydrogenated Castor Oil 0.6 One 0.5 2 Polysorbate-60 0.4 0.6 0.8 One Neutralization Triethanolamine 0.3 0.5 0.4 0.3 solvent Ethanol (ethyl alcohol) 60 62 63 62 adding Centella asiatica extract 0.1 0.2 0.1 0.2 Purslane extract 0.3 0.1 0.3 0.1 Cinnamon extract 0.2 0.2 0.2 0.2 sub Total 100 100 100 100

[Examples 9 to 12: Preparation of oil-in-water emulsion gel cream]

Examples 9 to 12 are examples in which a moisturizing agent and an active ingredient are blended in an oil phase, and a silicone oil and vegetable oil are mixed. An oil-in-water emulsion cream gel was prepared using a polyoxyethylene-based synthetic surfactant as a surfactant. Preparation was carried out according to the method described in Examples 1 to 4.

division Ingredient name Example 9
Content (wt%) Example 10
Content (wt%) Example 11
Content (wt%) Example 12
Content (wt%) Award Propylene glycol 3 5 One 3 PEG-400 2 One 5 3 2,3-butanediol 2 One 5 One 1,2-hexanediol 0.5 One 1.5 2 Purified water 25.647 21.774 25.39 24.499 Carbomer 0.3 0.5 0.4 0.3 Hydroxyethyl cellulose 0.1 0.1 0.1 0.1 Paid part Vitamin E Acetate 1.5 1.5 1.2 One Ascorbyl Tetraisopalmitate One 0.8 0.5 0.3 Squalane 0.2 0.5 0.7 One Sunflower seed oil 0.2 0.1 0.3 0.4 Dimethicone - 0.1 0.3 0.5 Stearic Acid 0.5 One 1.5 2 Cetearyl alcohol 2 One 0.5 0.1 PEG-40 Hydrogenated Castor Oil 0.6 One 1.5 2 Polysorbate-60 0.4 0.6 0.8 One Neutralization Triethanolamine 0.3 0.5 0.4 0.3 solvent Ethanol (ethyl alcohol) 59.653 62.326 53.81 57.201 adding Centella asiatica extract 0.1 0.2 0.1 0.2 Purslane extract 0.3 0.1 0.3 0.1 Cinnamon extract 0.2 0.2 0.2 0.2 sub Total 100 100 100 100

[Experimental Example 1: Observation and Measurement of Emulsified Particles of Oil-in-Water Type Prepared in the Example]

5 is a photomicrograph of observing emulsified particles through an optical microscope for the final product prepared using Example 1. FIG. This picture was taken with an optical microscope magnified at 400x, and the size of the emulsified particles was measured using a software program installed with it. In the microscopic state, the particle size cannot be accurately measured, but as shown in the picture, it was observed that the particles were around 3㎛ on average, and the dispersed state was homogeneously formed in a uniform size to form a stable emulsified state.

In addition, Figure 6 is a graph showing the results of measuring the emulsion particles using a particle size measuring device. As shown in the graph, it was found that the emulsion particle size distribution had a distribution of 0.1~20㎛, and the average particle diameter had a fine particle size of 2.5㎛.

7 is a photograph of the final result of an oil-in-water type milky cream gel made based on Example 1. As you can see in the photo, it had a very white milky color, and the exterior was shiny and soft, moist and soft creamy. This cream had a pH of 6.25 and a viscosity of 27000 cps as a value measured by stirring for 1 minute at 12 rpm with the 6th spindle of a Burgfield RV viscometer.

8 is a photograph of the final result of Comparative Example 1. Comparative Example 1, which is a conventional technique, had a different appearance and technical difference from Example 1 of the present invention. The difference in performance could be expected to be much larger and have various differentiations.

9 shows a sterilizing effect while the high content of alcohol is volatilized after Example 1 is applied to the skin, and the remaining emulsified cream is applied to the skin to protect the skin and absorb into the skin to provide various moisturizing and irritation. It is a photograph showing that it can be a good alternative to solve the conventional shortcomings by giving relief effect and improvement of dry skin. The left side of FIG. 9 is a photograph of an oil-in-water type cream applied to the skin. The middle photograph of FIG. 9 is a photograph in which ethanol is evaporated while exerting a sterilizing effect by rubbing the contents. The right photo of FIG. 9 is a photo showing that ethanol is neatly removed to improve clean skin.

10 is a graph for evaluating antibacterial activity compared to Comparative Example 1 in order to evaluate the antibacterial activity of Example 1. FIG. It was found that the antimicrobial activity of Example 1 has an excellent antibacterial effect compared to Comparative Example 1 against bacteria, fungi, staphylococcus aureus, and fungi. Although Example 1 contained the same amount of ethanol as compared to Comparative Example 1, it could be interpreted that the emulsified cream exerts a synergistic effect by additionally protecting the skin, resulting in such a result.

11 is a graph evaluating the hand disinfection effect for Example 1 and Comparative Example 1. Ten subjects were selected, evaluated on a 10-point scale, and averaged. In the disinfection effect (10 point scale), Example 1 was 9.57, and Comparative Example 1 was 8.95. Example 1 was more excellent than Comparative Example 1.

12 is a graph evaluating the alcohol allergy reduction effect in Example 1 and Comparative Example 1. Ten subjects were selected, evaluated on a 10-point scale, and averaged. In the allergy reduction effect (10-point scale), Example 1 was 9.7, which did not cause allergic stimulation, and Comparative Example 1 was 5.3, indicating that moderate allergy occurred. Example 1 was found to be about twice as excellent as that of Comparative Example 1, and it was believed that this is because the oil-in-water hydrophilic milky cream gel of Example 1 reduced skin irritation and prevented ethanol dryness.

13 is a graph for evaluating the effect of improving dry skin in Example 1 and Comparative Example 1. Ten subjects were selected, evaluated on a 10-point scale, and averaged. In the skin dryness improvement effect (10 point scale), it was found that in Example 1, skin dryness did not occur at 9.2, and in Comparative Example 1, it was found that skin dryness occurred severely at 3.7. In the case of Example 1, when applied to the skin and rubbed as if massaging, the sterilization effect is achieved immediately, ethanol is evaporated rapidly, and an oil-water emulsion is applied to the skin surface to supply moisture to the skin, so that dry skin does not occur. Could be evaluated.

14 is a graph for evaluating the skin moisturizing persistence effect for Example 1 and Comparative Example 1. Again, 10 subjects were selected, evaluated on a 10-point scale, and averaged. As for the evaluation method, the moisture content was measured using a moisturizing power meter (Skicon-200). Regarding the amount of residual skin moisture (%), Example 1 was 58.7% immediately after application, 43.2% after 1 hour, 35.9% after 2 hours, 23.3.9% after 4 hours, and after 6 hours It was found that the moisturizing power was maintained at 17.4% and 13.9% after 8 hours. Comparative Example 1 was 58.7% immediately after application, 19.2% after 1 hour, 12.5% after 2 hours, 11.3.9% after 4 hours, 9.3% after 6 hours, and 8.9 after 8 hours. It was found to maintain the moisturizing power in %, and it was found to decrease rapidly after 1 hour.

On the other hand, the moisturizing power of the skin itself before application was 8.2%. When calculated based on the moisturizing effect before application, it was found that the moisturizing effect after 8 hours was 13.9% in the case of Example 1, which was 69.5% improved than before application.

15 is a graph comparing and evaluating the skin cleansing effect for Example 1 and Comparative Example 1. Ten subjects were selected, evaluated on a 10-point scale, and averaged. Regarding the skin cleansing effect (10 point scale), Example 1 had an excellent cleansing effect of 9.1, and Comparative Example 1 had a moderate cleansing effect of 7.8.

Claims (8)

(A) preparing an aqueous phase by dispersing and dissolving carbomer or xanthan gum in an aqueous mixture containing purified water;
(B) preparing an oil phase by adding and dissolving polyglyceryl-10 isostearate and polyglyceryl-10 oleate, which are surfactants, to a fat-soluble mixture containing oil;
(C) inducing an emulsification reaction by mixing and stirring the aqueous phase prepared in step (a) and the oil phase prepared in step (b);
After step (c), adding a neutralizing agent to adjust the pH to 5.5 to 7.5 (d);
After the step (d), to prepare an oil-in-water emulsion gel cream containing ethanol, including the step (e) of adding ethanol,
The ethanol-containing oil-in-water emulsion gel cream is a method for producing an ethanol-containing oil-in-water emulsion gel cream, characterized in that it has an antibacterial effect and a moisturizing effect.
The method of claim 1,
The manufacturing method of the oil-in-water emulsion gel cream,
After the step (e), the step (f) of adding an additive including a moisturizing agent and a soothing agent;
The method of claim 1,
The aqueous mixture containing the purified water,
A method for producing an oil-in-water emulsion gel cream containing ethanol, comprising a mixture of glycerin, dipropylene glycol, 1,2-hexanediol, and purified water.
The method of claim 1,
The oil-soluble mixture containing the oil,
Canola oil or rapeseed oil, grape seed oil, apricot seed oil, peppermint oil, macadamia seed oil, argan kernel oil, and shea butter are mixed.
The method of claim 1,
The surfactant,
As a stabilizer, a method for producing an oil-in-water emulsion gel cream containing ethanol, further comprising cetearyl alcohol.
The method of claim 1,
The neutralizing agent,
Method for producing an oil-in-water emulsion gel cream containing ethanol, characterized in that it is arginine or triethanolamine.
The method of claim 2,
The additive,
A method for producing an oil-in-water emulsion gel cream containing ethanol, characterized in that at least one selected from sodium hyaluronate and allantoin.
The method of claim 1,
The ethanol,
A method of producing an oil-in-water emulsion gel cream containing ethanol, characterized in that 58 to 70% by weight is added to the total composition of the oil-in-water emulsion gel cream.

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