CN105769698B - A kind of cosmetic composition and its application without preservative - Google Patents

Abstract

The present invention relates to a kind of cosmetic compositions without preservative, it includes the following component based on mass percentage: salicylic acid/dextrin/xanthan gum/amylopectin 0.5-5%, aloe extract 0.1-3%, parahydroxyacet-ophenone 0.4-1%, avenabeta glucosan 0.5-10%, Gotu Kola P.E 0.01-10%, 1,2- pentanediol 1-3%, surplus are auxiliary material.The present invention also provides the application of the composition, composition of the invention can play the role of antibacterial anti-inflammatory, repair wound scar, replenishing water and preserving moisture, improve sebum secretion, can be used for repairing the various skin injuries including small pox skin.In addition, the composition is free of preservative, cosmetics are effectively reduced on the stimulation of skin and influence, do not easily cause the discomfort of face skin；Mildly, non-stimulated, it is suitble to all kinds of skin quality crowds to use.

Description

A kind of cosmetic composition and its application without preservative

Technical field

The present invention relates to cosmetic fields, and in particular to a kind of cosmetic composition and its application without preservative.

Background technique

With rapid development of economy, work, rhythm of life are getting faster, in addition city Air Contamination further adds The influence of many factors such as the undesirable work and rest habit of people, incorrect skin nursing, more and more under play and high pressure are lived People all by the skins disorder such as drying, coarse, the colour of skin is obscure, pore is coarse, small pox synthtic price index perplex.Especially by In factors such as environment, eating habit change, stress increases, the disease incidence of small pox is caused to show an increasing trend year by year.Small pox Also referred to as " acne ", " dark sore ", are a kind of chronic inflammatory skins of pilosebaceous follicle, feature be the acne for being mainly in face, All kinds of skin injuries such as papule, warts, tubercle.The generation of acne and hypersteatosis, pilosebaceous duct blocking, bacterium The factors such as infection and inflammatory reaction are closely related.Its reparation course of disease is slow, Yi Fanfu, beauty beauty is seriously affected, to people's heart Reason Health and Living quality affects greatly.Therefore, the reparation problem of skin is particularly important, especially small pox skin The reparation problem of skin.Currently, anti-acne, moisturizing, sterilization, reparation etc. are mostly realized in existing cosmetics using chemical synthesis substance Effect, although its chemical synthesis substance used and preservative etc. are to skin although these substances can complete above-mentioned function Skin has very strong irritation, is easy to appear the adverse reactions such as allergy, and deteriorate the skin being damaged, it is also possible to make to disappear The person of expense generates product is used for a long time possibly even the hormone secretion for influencing user using relying on, and then destroys user's Health.Since anti-acne repairs the limitation of efficacy assessments method, existing anti-acne repairs product, and also generally existing anti-acne is repaired Multiple limitation functionally.

Summary of the invention

The purpose of the present invention is to provide a kind of cosmetic compositions without preservative and its application, the composition can Play the role of antibacterial anti-inflammatory, repair wound scar, replenishing water and preserving moisture, improve sebum secretion, including can be used for repairing small pox skin Various skin injuries.Therefore, it, which has, improves skin blood circulation, increases skin elasticity, accelerates wound healing, smooth skin The effect of surface of a wound, reduction scar and pigmentation.In addition, the composition is free of preservative, cosmetics are effectively reduced to skin The stimulation and influence of skin, do not easily cause the discomfort of face skin；Mildly, non-stimulated, it is suitble to all kinds of skin quality crowds to use.

To solve the above problems, the technical solution adopted in the present invention is as follows:

A kind of cosmetic composition without preservative comprising the following component based on mass percentage:

Salicylic acid/dextrin/xanthan gum/amylopectin 0.5-5%, aloe extract 0.1-3%, parahydroxyacet-ophenone 0.4- 1%, avenabeta glucosan 0.5-10%, Gotu Kola P.E 0.01-10%, 1,2- pentanediol 1-3%, surplus is auxiliary material.

Salicylic acid/dextrin/xanthan gum/amylopectin (INCI: Salicylic Acid/Dextrin/Xanthan ), Gum/Amylopectin salicylic acid is a kind of pair of acne compound with good therapeutic effect.It is unique fat-soluble Carboxylic acid, thus pore depths can be penetrated into, pore is dredged, dead skin cells can be effectively cleared up, and is impaired and dead in cleaning The cell of health will not be impacted when dying cell.It is slightly soluble in cold water, is soluble in hot water, ethyl alcohol, ether and acetone, at present Common measure includes into salt plus surfactant, cyclodextrin encapsulated or use ethyl alcohol water mixed solvent hydrotropy.U.S.'s skin disease Learn (AAD) evaluate salicylic acid: " it is a kind of effective skin cleaner, it can cross into pore and help to remove it is extra The horn cell of fat, spot and death mitigates scytitis, prevents the formation of whelk ".Food and Drug Adminstration of the US (FDA) and the salicylic acid safe concentration of U.S.'s dermatology meeting (AAD) allowance is 0.5-2%, in China's regulation skin protection cosmetics Adding salicylic upper limit of concentration is 2%.

Aloe (Aloe, including aloe barbadensis Miller, aloe, Aloe ferox Miller, Aloe Perryi Baker) extract: aloe contains anthracene Quinone derivative, aloe rheum officinale, saponin, amino acid and polysaccharide etc..With moisture-keeping function, anti-sunlight function, anti-aging effects, sterilization work With, anti-inflammatory effect, immune and palingenesis, analgesia, sedation, antisepsis.Its main mechanism is (1) natural guarantor Wet and water lock effect promotes fibrous polymer albumen to be converted into NMF, to increase natural moisturizing factor, increases water content immediately, leads to It crosses slight filming function and reduces percutaneous water loss (28 days reduce 20%)；Carbohydrate and Amino acid profile in aloe are natural Moisturizing factor can supplement the moisture lost in skin, restore the function of collagen.Collagen has the function of water storage and changes The effect of water inlet metabolism；(2) one layer of smooth hygroscopic mem-brane can be formed in skin surface, because being rich in polysaccharide, is not increasing viscosity In the case of promote the flexibility and beautiful feeling of formula, and releive；(3) anti-inflammatory and healing of wound effect, include life Object enzyme plays the role of bactericidal antiphlogistic, and under amino acid, with collagen egg in cuticula by slowly hydrolyzing with skin White effect, healing of wound.Japanese scholars pass through research in 8 years, find in aloe also containing there are three types of chemical component, A Lao meter piperazines (Alomicin), Aloetin (Aloetin), Ah's Laue crow Rosin (Aloeulcin).And it is aobvious to think that A Lao meter piperazine has cancer Antagonism is write, Aloetin has strong antibacterial and mycostatic nature, can inhibit the development of pathogen bacteria, breed and largely kill Them are gone out, Ah's Laue crow Rosin plays Healing to scald, burn, scratch and ulcer, has significant treatment wound ability, can For the part of wound, it is substantially all and will not leave behind scar.

Parahydroxyacet-ophenone: a kind of natural equivalent compound, being present in Lampaya hieronymi, (herbal medicine originates in drawing Fourth America) and Rubus chamaemorus in (molka is grown on alpine zone).It is for having anti-irritant in cosmetic formulations Activity and the novel material for promoting preservative efficacy are made with other anti-corrosion promotors with the use of still having good preservative efficacy To will not influence stability of emulsion again while anti-corrosion synergist.In addition it also have anti-oxidant, anti-irritant, emulsion stabilizer and The multi-efficiencies such as product protection agent.It can be dissolved in glycerol, water, glycol, ethyl alcohol and caprylic/capric triglyceride, additionization Operating procedure is simple in cosmetic.It and some specific proteins have potential incompatibility, therefore work as in formula and contain albumen It when matter, needs to measure formulation stability, avoids changing colour.

Avenabeta glucosan: a kind of natural non-starch class water-soluble plant sugar being present in big oat hull, it can accelerate The immunocyte for determining crowd mitigates the reaction of bacterium infection and controls the position of bacterium infection, as early as possible restores infection face； With unique straight-chain molecular structure, good Transdermal absorption performance is imparted；Promote fibroblast to synthesize collagen, promotees Into wound healing, impaired skin is repaired, skin is given and moistens smooth sense of touch such as silk.In addition, it is sun-proof except itself having Effect (free radical scavenging ability, confrontation uv damage) simultaneously can be reduced outside pain inflammation, moreover it is possible to resisting skin allergy ability is improved, Activate immune function, skin moisture-keeping, a variety of effects such as delay skin aging.Its powerful activation both originated to macrophage Effect.It is well known that macrophage is not only the non-single-minded cytotoxin of malignant cell, while it can also attract immune work Property cell and other white blood corpuscles, to promote wound healing and generate normal tissue.Although macrophage membrane receptor is divided It separates out and, but the activation mechanism of macrophage is also imperfectly understood.Avenabeta glucosan can be identified simultaneously by macrophage well Promote macrophage breeding, it may be possible to due to caused by its special snail stereochemical structure.

Gotu Kola P.E: a kind of drying herb of dicotyledonous umbelliferae centella, for perennial draft plant of crawling Object often crispaturas into bulk, and stem is elongated, and tubercle is taken root, and happiness is born in wet riverbank, marsh, in meadow, is mainly distributed in China The each province on the south the Changjiang river.In recent years, a large amount of research confirms that Gotu Kola P.E has the function of immunological regulation, antibacterial, anti-inflammatory； Promote collagen in skin corium to be formed, regenerates fibrin, reconnect is got up, and compact epidermis and corium interconnecting piece are passed through Cutis laxa phenomenon of determining is decomposed, skin is made to achieve the effect that compact smooth and promote the multiple functions such as wound healing.Centella Extract is asiatic acid and brahmic acid, asiaticosid and madacasso grass for the main active in cosmetics Glycosides.Its effect is as follows: (1) antibacterial action: asiatic acid and brahmic acid belong to active saponin substance, can acidifying plant Cytoplasm in cell, to protect plant itself to resist the invasion of yeast and mold.Gotu Kola P.E is to green pus bar Bacterium, staphylococcus aureus, Propiobacterium etc. have certain inhibiting effect.(2) antiinflammation: Gotu Kola P.E improve and Skin itself barrier function is repaired, to prevent and correct skin immunologic function disorder.(3) promote fibroblast and collagen thin The synthesis of born of the same parents: Gotu Kola P.E can promote the synthesis of collagen I and III, while can also promote the secretion of mucopolysaccharide (synthesis of such as hyaluronic acid), increases the water conservation degree of skin, and activated fibroblast gene enhances the work of skin basal layer cell Power keeps elasticity of skin and consolidation sense, smooth face's fine wrinkles to make skin rich in reflecting feel.(4) improve colour of skin effect: product Avenging careless extract has stronger antioxidation, can inhibit free radical activity, desalination melanin pigmentation, improvement skin blood and follows Ring promotes skin cell regeneration, and melanin is helped smoothly to be metabolized out in vitro, keeps the smooth delicacy of skin, whitening beautiful.(5) scar Repair: pharmacological research made by domestic and foreign scholars shows that there is Gotu Kola P.E outstanding healing of wound and scar to repair Multiple effect, reason are that asiaticosid has and promote the important work such as internal collage synthesis and new vascular generation, stimulation granulation growth With, therefore be conducive to wound healing.

Pentanediol (1,2- pentanediol): pentanediol is good moisturizer, the colourless liquid for having slight characteristic odor, and There is excellent broad spectrum antibiotic activity.It has synergistic effect between traditional preservatives, can be strong while reducing preservative dosage Chemoprevention corruption system performance and the irritation that protective system is effectively reduced.It is particularly suitable for the delicate skin such as infant and aging The nursing of dry skin.

Cosmetic composition of the present invention, with salicylic acid/dextrin/xanthan gum/amylopectin, aloe extract, to hydroxyl Based on benzoylformaldoxime, avenabeta glucosan, Gotu Kola P.E, 1,2- pentanediol, has anti-acne by addition auxiliary material preparation Repair the cosmetic composition of effect.

Auxiliary material of the present invention include one or both of water, alcohols, finish, pH adjusting agent, surfactant with On.Wherein, the alcohols is selected from one of 1,3-PD, 1,2-PD, glycerine or 1,3-BDO or two Kind or more.The finish is selected from one or more of semi-synthetic grease, higher alcohol, animal and plant fat or silicone oil. The surfactant be selected from for emulsifying, the anionic surfactant of hydrotropy, nonionic surfactant or both sexes One or more of surfactant.The pH adjusting agent is in citric acid-sodium citrate, lactic acid-sodium lactate One kind.

In order to achieve the purpose that be promoted anti-acne, moisturizing, sterilization, repair, auxiliary material of the present invention further includes compounding The other compositions of other compositions, the compounding are selected from purslane extract, dipotassium glycyrrhizinate, panthenol, Sodium Hyaluronate, allantois One or more of element, camomile extract, antiallergic antipruritic.Wherein, the compounding ingredient accounts for the cosmetics group Close the 0.01%-10%, preferably 0.1%-5% of object gross mass.

Cosmetic composition of the present invention is in water aqua type cosmetics, emulsion-type cosmetics, gelling agent cosmetics or face It is applied in membranous type cosmetics.

Preferably, the water aqua type cosmetics are that a kind of anti-acne repairs essence dew comprising based on mass percentage Following component:

Salicylic acid/dextrin/xanthan gum/amylopectin 0.5-3%, aloe extract 0.3-3%, parahydroxyacet-ophenone 0.5- 0.8%, avenabeta glucosan 0.5-3%, Gotu Kola P.E 0.3-10%, 1,2- pentanediol 1-2%；

Auxiliary material: butanediol 3-7%, antiallergic antipruritic 0.5-1%, 1,3-PD 5-12%, hydroxyethyl cellulose 0.1- 0.5%, EDTA-2Na 0.05-0.1%, dipotassium glycyrrhizinate 0.08-0.15%, allantoin 0.01-0.3%, D-pantothenyl aleohol 0.5- 2%, Sodium Hyaluronate 0.01-0.1%, Purslane extract 0.5-3%, camomile extract 0.5-3%, sodium citrate 0.3- 0.35%, citric acid 0.004-0.008%, purified water supplies 100%.

Preferably, the face paste type cosmetics are that a kind of anti-acne repairs mask comprising based on mass percentage Following component:

Salicylic acid/dextrin/xanthan gum/amylopectin 0.5-1%, aloe extract 0.1-1%, parahydroxyacet-ophenone 0.4- 0.7%, avenabeta glucosan 0.5-2%, Gotu Kola P.E 0.01-0.5%, 1,2- pentanediol 1-1.5%；

Auxiliary material: butanediol 3-5%, antiallergic antipruritic 0.5-1%, 1,3-PD 5-10%, xanthan gum 0.1-0.3%, EDTA-2Na 0.05-0.1%, dipotassium glycyrrhizinate 0.08-0.15%, allantoin 0.01-0.3%, glycerol 1-4%, hyaluronic acid Sodium 0.01-0.1%, sodium citrate 0.23-0.35%, citric acid 0.003-0.005%, purified water supply 100%.

Preferably, the emulsion-type cosmetics are that a kind of anti-acne repairs succinct cream comprising based on mass percentage Following component:

Salicylic acid/dextrin/xanthan gum/amylopectin 0.5-2%, aloe extract 0.3-3%, parahydroxyacet-ophenone 0.5- 1%, avenabeta glucosan 0.5-2%, Gotu Kola P.E 0.3-3%, 1,2- pentanediol 1-2%；

Auxiliary material: tristerin and PEG-100 tristerin 0.5-3%, polydimethyl siloxane fluid 1-3%, L- essence Propylhomoserin 0.8-1.5%, carbomer 0.8-1.5%, hexadecanol 0.1-2%, caprylic/capric glyceryl ester 3-6%, saualane 1- 2%, polysorbate60 1-4%, EDTA-2Na 0.05-0.1%, dipotassium glycyrrhizinate 0.08-0.15%, allantoin 0.01-0.3%, D-pantothenyl aleohol 0.5-1%, Sodium Hyaluronate 0.01-0.1%, citric acid 0.004-0.01%, essence 0.02%, purified water is supplied 100%.

Preferably, the gelling agent cosmetics are that a kind of anti-acne repairs gel comprising based on mass percentage Following component:

Salicylic acid/dextrin/xanthan gum/amylopectin 0.5-2%, aloe extract 0.3-0.8%, parahydroxyacet-ophenone 0.5-1%, avenabeta glucosan 0.5-2%, Gotu Kola P.E 0.3-0.8%, 1,2- pentanediol 1-2%；

Auxiliary material: butanediol 3-10%, concentrated glycerin 3-5%, L-arginine 1-1.5%, carbomer 1-1.5%, EDTA-2Na 0.05-0.1%, dipotassium glycyrrhizinate 0.08-0.13%, allantoin 0.01-0.1%, D-pantothenyl aleohol 0.5-1%, Sodium Hyaluronate 0.01-0.05%, citric acid 0.003%, purified water supplies 100%.

Compared with the prior art, the advantages of the present invention are as follows:

Salicylic acid of the invention, aloe, the anti-acne repair of Gotu Kola P.E and avenabeta glucosan are especially prominent. Aloe contains vitamin abundant, amino acid, fatty acid, polysaccharose substance, can soon penetrate into skin, and go directly deep skin, There is certain repair to the various skin injuries including small pox skin；Aloe also contains panimmunity protective factors and more Glucide can prevent the delayed hypersensitivity of ultraviolet induction, and inflammation-resisting itch-stopping mitigates postinflammatory pigmentation, favorably In the recovery of impaired skin；In addition the mucoprotein of aloe can also make mass reduction other than it can promote normal cell growth, accelerate Repair of damaged tissues.By promoting granulation to be formed and the decomposition of various enzymes is to remove dead cell and infected group It knits.It not only has extremely strong anti-inflammatory and bactericidal effect, also has the work for promoting cell metabolism and then promoting regeneration With.Gotu Kola P.E can promote the synthesis of collagen I and III, while can also promote secretion (such as hyaluronic acid of mucopolysaccharide Synthesis), increase the water conservation degree of skin, activation updates Skin Cell, so that skin releived, promoted and rich in reflecting feel；Pass through CDNA arrangement testing research also found that Gotu Kola P.E also has the activation of fibroblast gene, can enhance skin The vigor of basal layer cell keeps elasticity of skin and consolidation sense, smooth face's fine wrinkles.Avenabeta glucosan has unique Straight-chain molecular structure imparts good Transdermal absorption performance；Promote fibroblast to synthesize collagen, wound is promoted to be cured It closes, repairs impaired skin, give skin and moisten smooth sense of touch such as silk.Salicylic acid is a kind of natural skin-protecting factor, energy Enough effectively cleaning dead skin cells, dredging pore, dissolution acne, can also allow coarse skin to become smooth, pale.Para hydroxybenzene second Ketone has the multi-efficiencies such as anti-oxidant, anti-irritant, emulsion stabilizer, anti-corrosion promotor and product protection agent.Pentanediol has excellent Broad spectrum antibiotic activity and performance of keeping humidity.Using the cosmetic composition that they are configured to as composition, can obtain safety and Efficient anti-acne repairing effect.

1. effectively reducing cosmetics to skin the present invention provides a kind of cosmetic composition without preservative Stimulation and influence, do not easily cause the discomfort of face skin；Mildly, non-stimulated, it is suitble to all kinds of skin quality crowds to use.

2. a kind of cosmetic composition without preservative provided by the invention contains natural moisturizing ingredient oat β-Portugal Glycan, while promoting the moisture absorption and water metabolism of skin, and promote absorption of the skin to other effective components；

3. a kind of cosmetic composition without preservative provided by the invention, is not added with artificial synthesized preservative, right Hydroxy acetophenone, 1,2- pentanediol, Gotu Kola P.E and aloe extract have synergetic antibacterial effect；After formula It does not need to add other preservatives, its irritation and neurological susceptibility to sensitive skin can be effectively reduced, make skin to effective The absorption of ingredient is more complete.

4. a kind of cosmetic composition without preservative provided by the invention, play antibacterial anti-inflammatory, repair wound scar, Replenishing water and preserving moisture improves the effect of sebum secretion, can be used for repairing the various skin injuries including small pox skin.So having improves The effect of skin blood circulation, increase skin elasticity, acceleration wound healing, smooth skin wound, reduction scar and pigmentation.

Detailed description of the invention

Fig. 1: the skin oil and fat content balance figure at subject's forehead each time point.

Fig. 2: the skin oil and fat content balance figure at the subject wing of nose each time point.

Fig. 3: the mean skin moisture content comparison diagram at subject's arm each time point.

Fig. 4: the photo of subject's original wound scar.

Fig. 5: the photo of wound scar after subject uses composition 2 months.

Fig. 6: the photo of wound scar after subject uses composition 6 months.

Specific embodiment

The embodiment of the present invention is specifically described below, in an embodiment of the present invention, cosmetics of the present invention The proportion of composition uses weight percent meter, can be content unit well known to the field of medicaments such as μ g, mg, g, kg.The present invention Each ingredient can be bought from chemical industry or medical market in the cosmetic composition.Cosmetic composition system of the present invention Standby cosmetics or the unlimited setting state of skin care item preparation, such as, but not limited to, aqua, emulsion, gelling agent and facial mask can be made Deng form.

Embodiment 1-3

Cosmetic composition described in the present embodiment is fabricated to a kind of water aqua type cosmetics, and specially a kind of anti-acne repairs essence Hua Lu, formula are shown in Table 1.

The proportion table of 1 embodiment 1-3 of table

Anti-acne described in the present embodiment repairs the preparation method of essence dew, sequentially includes the following steps:

1) sterilization of instruments: first the instruments Appliances including reaction kettle are cleaned with 80 DEG C of -100 DEG C of aqua sterilisas, are then used 75% ethanol for disinfection rinses, cold wind drying；

2) it feeds: the purified water of formula ratio being added into reaction kettle, begins to warm up, stirring is opened, by propylene glycol, fourth two It is added and stirs evenly after alcohol, pentanediol and hydroxyethyl cellulose mixing, then successively EDTA-2Na, parahydroxyacet-ophenone are added instead It answers in kettle, is heated to 70-80 DEG C, stirring is allowed to sufficiently dissolve, and keeps the temperature half an hour, opens cooling, water is added when being down to 45-50 DEG C Poplar acid/dextrin/xanthan gum/amylopectin, dipotassium glycyrrhizinate, aloe extract, Gotu Kola P.E, allantoin and hyaluronic acid Sodium, stirring and dissolving are uniform.Continue to be down to 40-45 DEG C of addition avenabeta glucosan, D-pantothenyl aleohol, Purslane extract, chamomile and mention Object and antiallergic antipruritic are taken, stirring and dissolving is uniform；

3) it adjusts pH: appropriate citric acid and sodium citrate stirring and adjusting pH to 5.5-6.5 is added；

4) quality inspection dispenses: dispensing after being cooled to room temperature passed examination.

Embodiment 4-6

Cosmetic composition described in the present embodiment is fabricated to a kind of face paste type cosmetics, specially a kind of anti-acne repair surface Pad pasting, formula are shown in Table 2.

The proportion table of 2 embodiment 4-6 of table

Anti-acne described in the present embodiment repairs the preparation method of mask, sequentially includes the following steps:

1) sterilization of instruments: first the instruments Appliances including reaction kettle are cleaned with 80 DEG C of -100 DEG C of aqua sterilisas, are then used 75% ethanol for disinfection rinses, cold wind drying；

2) feed: into reaction kettle be added formula ratio purified water, begin to warm up, open stirring, by glycerol, propylene glycol, It is added and stirs evenly after butanediol, pentanediol and xanthan gum mixing, then reaction successively is added in EDTA-2Na, parahydroxyacet-ophenone In kettle, it is heated to 70-80 DEG C, stirring is allowed to sufficiently dissolve, and keeps the temperature half an hour, opens cooling, bigcatkin willow is added when being down to 45-50 DEG C Acid/dextrin/xanthan gum/amylopectin, dipotassium glycyrrhizinate, aloe extract, Gotu Kola P.E, allantoin and hyaluronic acid Sodium, stirring and dissolving are uniform.Continue to be down to 40-45 DEG C of addition avenabeta glucosan and antiallergic antipruritic, stirring and dissolving are uniform；

3) it adjusts pH: appropriate citric acid and sodium citrate stirring and adjusting pH to 5.5-6.5 is added；

4) quality inspection dispenses: dispensing after being cooled to room temperature passed examination.

Embodiment 7-9

Cosmetic composition described in the present embodiment is fabricated to a kind of emulsion-type cosmetics, and specially a kind of anti-acne repairs essence Pure cream, formula are shown in Table 3.

The proportion table of 3 embodiment 7-9 of table

Anti-acne described in the present embodiment repairs the preparation method of succinct cream, sequentially includes the following steps:

1) prefabricated solution: by Sodium Hyaluronate, allantoin, aloe extract, Gotu Kola P.E and dipotassium glycyrrhizinate, with suitable Aqueous solution is made in amount purified water, spare；

2) water phase: a suitable vessel is added in purified water, glycerol, butanediol, pentanediol and carbomer, is stirred It is even, polysorbate60, EDTA-2Na and parahydroxyacet-ophenone are added, is heated with stirring to 75-80 DEG C, it is spare；

3) oily phase: by tristerin and PEG-100 tristerin, polydimethyl siloxane fluid, hexadecanol, octanoic acid/ A suitable vessel is added in capric acid glyceryl ester and saualane, is uniformly mixed, and is heated to 75-80 DEG C, spare；

4) water phase and oil are mixed, homogeneous 5-10 minutes, then stops homogeneous, stirring cooling；

5) 60 DEG C are cooled to, L-arginine is added, continues stirring cooling；

6) 45 DEG C are cooled to, addition salicylic acid/dextrin/xanthan gum/amylopectin, prefabricated solution, D-pantothenyl aleohol, oat β-Portugal are poly- Sugar and essence continue stirring cooling；

7) it adjusts pH: appropriate citric acid stirring and adjusting pH to 6-7 is added；

8) 28 DEG C are cooled to, allotment terminates.

Embodiment 10-12

Cosmetic composition described in the present embodiment is fabricated to a kind of gelling agent cosmetics, and specially a kind of anti-acne repairs Gel Curry, formula are shown in Table 4.

The proportion table of 4 embodiment 10-12 of table

Anti-acne described in the present embodiment repairs the preparation method of gel, sequentially includes the following steps:

1) prefabricated solution: by Sodium Hyaluronate, allantoin, aloe extract, Gotu Kola P.E and dipotassium glycyrrhizinate, with suitable Aqueous solution is made in amount purified water, spare；

2) water phase: a suitable vessel is added in purified water, glycerol, butanediol, pentanediol and carbomer, is stirred It is even, EDTA-2Na and parahydroxyacet-ophenone are added, is heated with stirring to 75-80 DEG C；

3) stirring cooling is cooled to 60 DEG C, and L-arginine is added, and continues stirring cooling；

4) 45 DEG C are cooled to, salicylic acid/dextrin/xanthan gum/amylopectin, prefabricated solution, D-pantothenyl aleohol and oat β-Portugal is added Glycan continues stirring cooling；

5) it adjusts pH: appropriate citric acid stirring and adjusting pH to 5.5-7 is added；

6) 28 DEG C are cooled to, allotment terminates.

The product made to embodiment 1-12, referring to 2015 USP of United States Pharmacopeia, 38 editions Microbial Challenges test into Row test.Detection method and detection data see below:

The made product of above-described embodiment 1-12 is weighed respectively, is carried out within the 0th day inoculation plus bacterium operation in test, is existed respectively The bacteria containing amount in the 7th day, the 14th day and the 28th day sampling analysis sample after adding bacterium.

Test result is as shown in table 5:

The Microbial Challenge of 5 embodiment 1-12 of table is tested

The product of embodiment 1-12, after inoculation the 7th day, all clump counts were 0cfu/g, comparing with intial value, carefully Bacterium tests bacterium number decline and is no less than 1.0lg, and the increased quantity of mycologic test bacterium is no more than 0.5lg；After inoculation the 14th day, institute Having clump count is 0cfu/g, and comparing with intial value, the decline of bacteria test bacterium number is no less than 2.0lg, and mycologic test bacterium is increased Quantity is no more than 0.5lg；After inoculation the 28th day, all clump counts were 0cfu/g, and compared with 14 days, bacteria test bacterium increases The quantity added is no more than 0.5lg, and comparing with intial value, the increased quantity of mycologic test bacterium is no more than 0.5lg；Test data table Bright, the product of embodiment 1-12 has good fungistatic effect.Microbial Challenge test carries out pass the test.

To anti-acne remediation composition (each component content: salicylic acid/dextrin/xanthan gum/amylopectin 2%, aloe extract 3%, parahydroxyacet-ophenone 0.6%, avenabeta glucosan 10%, Gotu Kola P.E 8%, 1,2- pentanediol 2%, purified water benefit Foot 100%.) carry out following experiment test:

1. inhibiting sebum secretion effect test:

Test sample: anti-acne remediation composition and water

Test method:

Skin health is randomly selected, 30 subjects of no skin disease and allergies draw 30 subject's face areas It is divided into left and right face, left face is blank control region, and right face is tested material the area of application, and left and right face can arbitrarily select the portion of face Position, including take symmetric points as test point at forehead, the wing of nose.Face is cleaned with clear water, is dried.By tested material with 1.25 μ L/cm2 applies density short-term 1 time and is coated on tested region (right face), gently pats to after absorbing, with skin oil measuring appliance (580 skinanalysis apparatus of MPA) measures the mean skin at each time point of each test point tested rear 0min, 30min, 1h, 2h respectively Fat content.

Test data as shown in the following table 6, table 7, Fig. 1 and Fig. 2, as the result is shown subject's forehead, that sample is smeared at the wing of nose is anti- Mean skin fat content value is lower than water after acne remediation composition, illustrates that anti-acne remediation composition has significant inhibition sebum point The effect secreted.

Table 6: the skin oil and fat content at subject's forehead each time point

Table 7: the skin oil and fat content at the subject wing of nose each time point

2. moisture-keeping efficacy is tested

Test sample: 0.1% aqueous solution of anti-acne remediation composition and hyaluronic acid.

Test method:

Skin health, 30 subjects of no skin disease and allergies are randomly selected, and choose the flexion of upper limb side of subject Area's proper area is test section.Tested region is passed through into clear water cleaning, then naturally dry after uniformly being wiped with alcohol before test 15min, with moisture of skin measurer (825 skinanalysis apparatus of CM) measure putting down before not smearing sample Equal moisture content of skin (blank value).Two kinds of samples for coating 30 μ L respectively in the range of subject inner forearm 3cm × 3cm are molten Liquid is smeared with finger substantially uniformity, is gently patted to after absorbing.It is smeared after five minutes with the measurement of moisture of skin measurer, 30 points Zhong Hou, after 1 hour, moisture content of skin after 2 hours compares the mean skin water content at two sample each time points.

Test data is as shown in the following table 8 and Fig. 3, the results show that smearing the mean skin after sample anti-acne remediation composition Water content is slightly above the mean skin water content value after smearing 0.1% aqueous solution of hyaluronic acid, illustrates anti-acne remediation composition Replenishing water and preserving moisture effect is preferable.

Table 8: the mean skin moisture content at subject's arm each time point

3, scar measure of merit is repaired:

Test sample: anti-acne remediation composition

Test method:

The sample solution for coating 0.5-1mL respectively in the range of subject's established wound scar sooner or later daily, is used Finger substantially uniformity is smeared, and is gently patted to after absorbing.After observation is smeared sample 2 months respectively, wound scar is repaired after 6 months Multiple effect.

It observes shown in result following Fig. 4, Fig. 5 and Fig. 6, the results show that after smearing sample anti-acne remediation composition 6 months Wound scar obviously improves, and illustrates that anti-acne remediation composition has the effect for repairing wound scar.

The above embodiment is only the preferred embodiment of the present invention, and the scope of protection of the present invention is not limited thereto, The variation and replacement for any unsubstantiality that those skilled in the art is done on the basis of the present invention belong to institute of the present invention Claimed range.

Claims (10)

1. a kind of cosmetic composition without preservative, which is characterized in that including the following component based on mass percentage:

Salicylic acid/dextrin/xanthan gum/amylopectin 0.5-3%, aloe extract 0.3-3%, parahydroxyacet-ophenone 0.5- 0.8%, avenabeta glucosan 0.5-3%, Gotu Kola P.E 0.3-10%, 1,2- pentanediol 1-2%, surplus is auxiliary material.

2. the cosmetic composition according to claim 1 without preservative, which is characterized in that the auxiliary material includes One or more of water, alcohols, finish, pH adjusting agent, surfactant.

3. the cosmetic composition according to claim 2 without preservative, which is characterized in that the alcohols is selected from 1, One or more of 3-propanediol, 1,2-PD, glycerine, 1,3-BDO；The finish is selected from semi-synthetic One or more of grease, higher alcohol, animal and plant fat, silicone oil；The surfactant is selected from for emulsifying, helping One or more of molten anionic surfactant, nonionic surfactant or amphoteric surfactant；It is described PH adjusting agent be selected from one of citric acid-sodium citrate, lactic acid-sodium lactate.

4. the cosmetic composition according to claim 2 without preservative, which is characterized in that the auxiliary material further includes multiple The other compositions of the other compositions matched, the compounding are selected from purslane extract, dipotassium glycyrrhizinate, panthenol, Sodium Hyaluronate, urine One or more of Bursin, camomile extract, antiallergic antipruritic；Wherein, the other compositions of compounding account for the makeup The 0.01%-10% of product composition gross mass.

5. the cosmetic composition according to claim 4 without preservative, which is characterized in that the compounding other Ingredient accounts for the 0.1%-5% of the cosmetic composition gross mass.

6. a kind of application of cosmetic composition described in -5 any one according to claim 1, which is characterized in that by cosmetics Composition is used to prepare water aqua type cosmetics, emulsion-type cosmetics, gelling agent cosmetics or face paste type cosmetics.

7. a kind of anti-acne repairs essence dew, which is characterized in that including the following component based on mass percentage:

Salicylic acid/dextrin/xanthan gum/amylopectin 0.5-3%, aloe extract 0.3-3%, parahydroxyacet-ophenone 0.5- 0.8%, avenabeta glucosan 0.5-3%, Gotu Kola P.E 0.3-10%, 1,2- pentanediol 1-2%；

Auxiliary material: butanediol 3-7%, antiallergic antipruritic 0.5-1%, 1,3-PD 5-12%, hydroxyethyl cellulose 0.1- 0.5%, EDTA-2Na0.05-0.1%, dipotassium glycyrrhizinate 0.08-0.15%, allantoin 0.01-0.3%, D-pantothenyl aleohol 0.5- 2%, Sodium Hyaluronate 0.01-0.1%, Purslane extract 0.5-3%, camomile extract 0.5-3%, sodium citrate 0.3- 0.35%, citric acid 0.004-0.008%, purified water supplies 100%.

8. a kind of anti-acne repairs mask, which is characterized in that including the following component based on mass percentage:

Salicylic acid/dextrin/xanthan gum/amylopectin 0.5-1%, aloe extract 0.1-1%, parahydroxyacet-ophenone 0.4- 0.7%, avenabeta glucosan 0.5-2%, Gotu Kola P.E 0.01-0.5%, 1,2- pentanediol 1-1.5%；

Auxiliary material: butanediol 3-5%, antiallergic antipruritic 0.5-1%, 1,3-PD 5-10%, xanthan gum 0.1-0.3%, EDTA- 2Na 0.05-0.1%, dipotassium glycyrrhizinate 0.08-0.15%, allantoin 0.01-0.3%, glycerol 1-4%, Sodium Hyaluronate 0.01-0.1%, sodium citrate 0.23-0.35%, citric acid 0.003-0.005%, purified water supply 100%.

9. a kind of anti-acne repairs succinct cream, which is characterized in that including the following component based on mass percentage:

Salicylic acid/dextrin/xanthan gum/amylopectin 0.5-2%, aloe extract 0.3-3%, parahydroxyacet-ophenone 0.5-1%, Avenabeta glucosan 0.5-2%, Gotu Kola P.E 0.3-3%, 1,2- pentanediol 1-2%；

Auxiliary material: tristerin and PEG-100 tristerin 0.5-3%, polydimethyl siloxane fluid 1-3%, L-arginine 0.8-1.5%, carbomer 0.8-1.5%, hexadecanol 0.1-2%, caprylic/capric glyceryl ester 3-6%, saualane 1-2% are spat Temperature 60 1-4%, EDTA-2Na0.05-0.1%, dipotassium glycyrrhizinate 0.08-0.15%, allantoin 0.01-0.3%, D-pantothenyl aleohol 0.5-1%, Sodium Hyaluronate 0.01-0.1%, citric acid 0.004-0.01%, essence 0.02%, purified water supplies 100%.

10. a kind of anti-acne repairs gel, which is characterized in that including the following component based on mass percentage:

Salicylic acid/dextrin/xanthan gum/amylopectin 0.5-2%, aloe extract 0.3-0.8%, parahydroxyacet-ophenone 0.5- 1%, avenabeta glucosan 0.5-2%, Gotu Kola P.E 0.3-0.8%, 1,2- pentanediol 1-2%；

Auxiliary material: butanediol 3-10%, concentrated glycerin 3-5%, L-arginine 1-1.5%, carbomer 1-1.5%, EDTA-2Na 0.05-0.1%, dipotassium glycyrrhizinate 0.08-0.13%, allantoin 0.01-0.1%, D-pantothenyl aleohol 0.5-1%, Sodium Hyaluronate 0.01-0.05%, citric acid 0.003%, purified water supplies 100%.