CN110013501A - Halitosis lozenge - Google Patents
Halitosis lozenge Download PDFInfo
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- CN110013501A CN110013501A CN201810013642.3A CN201810013642A CN110013501A CN 110013501 A CN110013501 A CN 110013501A CN 201810013642 A CN201810013642 A CN 201810013642A CN 110013501 A CN110013501 A CN 110013501A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/288—Taraxacum (dandelion)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
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Abstract
A kind of halitosis lozenge, which is characterized in that it is characterized in that, it is prepared by the component of following parts by weight: 45~55 parts of main ingredient, preferably 50 parts；45~55 parts of diluent, preferably 49.5 parts；0.3~0.8 part of excipient, preferably 0.5 part.Wherein, main ingredient includes each component of following parts by weight: 8~12 parts of spearmint essential oil, preferably 10 parts；3~8 parts of dandelion extracting solution powder, preferably 5 parts；Honeysuckle extracts 8~12 parts of powder, preferably 10 parts；8~12 parts of Herba Menthae Haplocalycis volatile oil, preferably 10 parts；3~8 parts of Baical Skullcap root P.E, preferably 5 parts；8~12 parts of probiotics bacterial powder, preferably 10 parts.Halitosis lozenge is made by the way that spearmint essential oil, dandelion extracting solution powder, honeysuckle are extracted powder, Herba Menthae Haplocalycis volatile oil, Baical Skullcap root P.E, probiotics bacterial powder as main ingredient in the present invention, it can inhibit halitosis Related Bacteria jointly, improve oral cavity ecology, fresh breath, to remove halitosis.
Description
[technical field]
The present invention relates to halitosis field, in particular to a kind of halitosis lozenge.
[background technique]
Halitosis is most of to be caused by mouth disease, and according to investigations, nearly 65% people once had the experience of halitosis, male
Halitosis disease incidence be apparently higher than women；Modern medicine thinks that the Etiological of halitosis is divided by oral cavity anaerobium excessive multiplication
Swill, organic matter and blood in solution digestion oral cavity, generate caused by volatile sulfide.Intraoral G- anaerobic bacteria, it is special
It is not that porphyromonas gingivalis, Prevotella intermedia, Fusobacterium nucleatum can decompose methionine, cysteine or haemocyanin and give birth to
At a large amount of VSC, this 3 kinds of bacteriums are considered as the smelly bacterium of main cause in oral cavity.Under normal circumstances, halitosis is by brushing teeth, gargling
Deng being difficult to eliminate, the social activity and mental health of people are influenced whether when halitosis is serious.
Many scholars, which start to explore, in recent years more effectively prevents antozostomatic method.Periodontosis, saprodontia, gingivitis are to compare
The inducement of common mouth source property halitosis.Currently, supragingival scaling and subgingival curettage are the conventional treatments of periodontosis, process
In for lasting effects, with the treatment of saprodontia, can be assisted in the treatment of using antibiotic and disinfectant, but also result in more serious
Flora imbalance.
In addition, halitosis lozenge is also one of pre- anti-caries, fresh breath and the main method for improving Oral health behaviours；It is existing
Halitosis lozenge, main component is Chinese materia medica preparation, and this halitosis lozenge in actual use, usually takes effect relatively slow, effect
Power is general.
[summary of the invention]
Present invention seek to address that the above problem, and provide a kind of using spearmint essential oil, dandelion extracting solution powder, gold and silver
Flower extracts the preparation method of powder, Herba Menthae Haplocalycis volatile oil, Baical Skullcap root P.E, probiotics bacterial powder as main halitosis lozenge.
To achieve the above object, the present invention provides a kind of halitosis lozenges, which is characterized in that it is by following parts by weight
Component is prepared:
Containing spearmint essential oil, dandelion extracting solution powder, honeysuckle extract powder, Herba Menthae Haplocalycis volatile oil, Baical Skullcap root P.E,
45~55 parts of the main ingredient of probiotics bacterial powder；
45~55 parts of diluent；
0.3~0.8 part of excipient.
Further, it is prepared by the component of following parts by weight:
Containing spearmint essential oil, dandelion extracting solution powder, honeysuckle extract powder, Herba Menthae Haplocalycis volatile oil, Baical Skullcap root P.E,
50 parts of the main ingredient of probiotics bacterial powder；
49.5 parts of diluent；
0.5 part of excipient.
Further, the main ingredient includes each component of following parts by weight:
8~12 parts of spearmint essential oil；
3~8 parts of dandelion extracting solution powder；
Honeysuckle extracts 8~12 parts of powder；
8~12 parts of Herba Menthae Haplocalycis volatile oil；
3~8 parts of Baical Skullcap root P.E；
8~12 parts of probiotics bacterial powder.
Further, the main ingredient is grouped as by each group of following parts by weight:
10 parts of spearmint essential oil；
5 parts of dandelion extracting solution powder；
Honeysuckle extracts 10 parts of powder；
10 parts of Herba Menthae Haplocalycis volatile oil；
5 parts of Baical Skullcap root P.E；
10 parts of probiotics bacterial powder.
Further, the probiotics bacterial powder is the active microbe powder as made from lactobacillus acidophilus and Bifidobacterium.
Further, the diluent includes one of cornstarch, dextrin, mannitol or a variety of.
Further, the diluent is made of cornstarch, dextrin, mannitol, weight ratio 3:1:1.
Further, the excipient is magnesium stearate.
Further, which is made of pressed disc method, and the specification of every tablet of halitosis lozenge is 0.5g.
Favorable attributes of the invention are, efficiently solve the above problem.Halitosis lozenge of the invention is in main ingredient
Spearmint essential oil, dandelion extracting solution powder, honeysuckle extract powder, Herba Menthae Haplocalycis volatile oil, Baical Skullcap root P.E, probiotics bacterial powder,
Wherein, probiotics bacterial powder can inhibit halitosis Related Bacteria, reduces VSC level, reduces oral peculiar smell；Spearmint essential oil it is main at
Dividing is carvol, with wind dispelling inducing diaphoresis, anti-inflammatory analgesic, antibacterial desinsection and other effects；Dandelion extract contain various active at
Point, such as caffeic acid, chlorogenic acid, ferulic acid, flavonoids, sesquiterpene lactone, Coumarins, fatty acid, saponins, polysaccharide,
Wherein caffeic acid and chlorogenic acid have bacteriostasis, and ferulic acid has the pharmacological actions such as antibacterial anti-inflammatory, antiviral, anti-oxidant；And
Contain chlorogenic acid and isochlorogenic acid in Honegsukle flower P.E, has the function of a variety of resisting pathogenic microbes, to cariogenic
Bacterium --- streptococcus mutans have preferable inhibition and bactericidal effect；Herba Menthae Haplocalycis volatile oil acrid flavour, cool in nature, nontoxic, having makes one implication
Fragrant clean effect；Baical Skullcap root P.E has resisting pathogenic microbes, antiallergic action, antiviral, antimycotic, anti-inflammatory, anti-oxidant etc.
Effect.The present invention is by extracting powder, Herba Menthae Haplocalycis volatile oil, radix scutellariae and mentioning spearmint essential oil, dandelion extracting solution powder, honeysuckle
It takes object, probiotics bacterial powder as main ingredient, diluent and excipient as adjuvant, is by weight the ratio of 1:1 by main ingredient and adjuvant
Halitosis lozenge is made in example, and main ingredient ingredient can inhibit halitosis Related Bacteria jointly, and antibacterial anti-inflammatory improves oral cavity ecology, and pure and fresh
Implication, to remove halitosis.
[specific embodiment]
The following example is that of the invention is explained further and being supplemented, and is not limited in any way to the present invention.
Embodiment 1
The halitosis lozenge of the present embodiment, specification are every 0.5g comprising 10 parts of spearmint essential oil, dandelion extracting solution
5 parts of powder, honeysuckle extract 10 parts of powder, 10 parts of Herba Menthae Haplocalycis volatile oil, 5 parts of Baical Skullcap root P.E, 10 parts of probiotics bacterial powder, diluent
49.5 parts, 0.5 part of excipient.Wherein, the number of above-mentioned each component is parts by weight, and main ingredient is spearmint essential oil, dandelion mentions
Liquid powder, honeysuckle is taken to extract powder, Herba Menthae Haplocalycis volatile oil, Baical Skullcap root P.E, probiotics bacterial powder, weight accounting is 50%, auxiliary
Expect diluent and excipient weight accounting is 50%.
The diluent is made of the ratio that cornstarch, dextrin, mannitol are 3: 1: 1 by weight.
In the present embodiment, the excipient is magnesium stearate.In other embodiments, other also can be selected in the excipient can
Replace substance.
The halitosis lozenge of the present embodiment is made by pressed disc method, the specific steps of which are as follows:
S1, dandelion extracting solution powder, honeysuckle are extracted after powder, Baical Skullcap root P.E be sieved respectively, according to the above ratio
It is uniformly mixed and obtains mixture；
S2, the spearmint essential oil of aforementioned proportion, Herba Menthae Haplocalycis volatile oil are mixed with the obtained mixture of step S1, is then sieved
It is granulated, dries in an oven, obtain particle, smash it through and sift out whole grain；
Probiotics bacterial powder, diluent and the excipient of aforementioned proportion is added in S3, the whole grain for obtaining step S2, is pressed
Halitosis lozenge is made in piece.
Wherein, the dandelion extracting solution powder is extracted by dandelion and is obtained, and is made by following steps:
11~15 times of water measured of addition are impregnated after S11, dandelion are ground into coarse powder, and the water of 13 times of amounts are preferably added
Impregnate 30min；Wherein, the water that 13 times of amounts are added, which refers to, to be added 13 times of volume of dandelion weight (unit be gram) (unit is
Milliliter) water, for example, dandelion weight be m grams when, then add 13m milliliters of water；
S12, it decocts 2~3 times, decocts 50~90min every time, decocting temperature is 70 DEG C~90 DEG C；2 are preferably decocted, often
Secondary decoction 70min, decocting temperature is 80 DEG C；
S13, relative density is concentrated into (with 1g/cm3As reference density) be 1.10~1.20 concentrate；
S14, ethyl alcohol is added in concentrate, so that its alcohol content is reached 50%~70% (volume), stirs evenly thereafter and stand
It filters to get filtrate after for 24 hours~48h；It stirs evenly and stands after so that its alcohol content is reached 60% (volume) and filter to obtain filter afterwards for 24 hours
Liquid.
S15, filtrate is concentrated, crushed after being dried, the dandelion extracting solution powder is made.
The honeysuckle extracts powder and is extracted by honeysuckle and obtained, and is made by following steps:
After S21, honeysuckle powder are broken into coarse powder, the water of 8~12 times of amounts is added；The pure water of 10 times of amounts is preferably added；Its
In, the pure water that 10 times of amounts are added refers to the pure of 10 times of volumes (unit is milliliter) that honeysuckle weight (unit is gram) is added
Water, for example, then adding 10n milliliters of pure water when honeysuckle weight is n grams；
S22, it is extracted at a temperature of 70 DEG C~90 DEG C 2~3 times, extracts 1~2H every time, obtain extracting solution；Preferably at 80 DEG C
At a temperature of extract 2 times, extract 1.5H every time；
S23, extracting solution is concentrated under reduced pressure, obtains concentrate；Preferably by extracting solution under the conditions of 70 DEG C, -0.07MPa
It is concentrated under reduced pressure；
S24, concentrate is dried, crushed after being dried, the honeysuckle is made and extracts powder；Preferably by concentrate
It is dried in 70 DEG C, -0.07MPa condition.Wherein, when dry, vacuum belt type drying can be used or drying of dusting.
The Baical Skullcap root P.E is extracted by radix scutellariae and is obtained, and is made by following steps:
S31, after radix scutellariae is ground into coarse powder, the ethyl alcohol that the volumetric concentration of 13~17 times of amounts is 65%~85% is added；It is excellent
The ethyl alcohol that the volumetric concentration for being selected as that 15 times of amounts are added is 75%；Wherein, the ethyl alcohol of 15 times of amounts of addition, which refers to, is added radix scutellariae weight
The ethyl alcohol of 15 times of volumes (unit is milliliter) of (unit is gram), for example, then adding 15X milliliters of second when radix scutellariae weight is X grams
Alcohol；
S32, it extracts 2~3 times, extracts 80~100min every time, obtain extracting solution；It preferably extracts 2 times, extracts every time
90min, Extracting temperature are 85 DEG C；
S33, it is dried after extracting solution is concentrated, the Baical Skullcap root P.E is made；
The spearmint essential oil is extracted by spearmint and is obtained, and is made by following steps:
The ethyl alcohol that the volumetric concentration of 10~14 times of amounts is 40%~60% is added after being ground into coarse powder in S41, spearmint, preferably
For the ethyl alcohol that the volumetric concentration of 12 times of amounts is 50% is added；Wherein, the ethyl alcohol of 12 times of amounts of addition, which refers to, is added spearmint weight
The ethyl alcohol of 12 times of volumes (unit is milliliter) of (unit is gram), for example, then adding 12M milliliters when spearmint weight is M grams
Ethyl alcohol.
S42, Dynamic Extraction is carried out under the conditions of 80~100 DEG C, extract 1.0~2.0H；Preferably under the conditions of 90 DEG C into
Mobile state extracts, and extracts 1.5H；
The ethyl alcohol that S43, the volumetric concentration that 8~12 times of amounts are added are 40%~60%, is preferably added the volume of 10 times of amounts
The ethyl alcohol that concentration is 50%；Wherein, the ethyl alcohol that 10 times of amounts are added refers to 10 times of volumes that spearmint weight (unit is gram) is added
The ethyl alcohol of (unit is milliliter), for example, then adding 10M milliliters of ethyl alcohol when spearmint weight is M grams.
S44, Dynamic Extraction is carried out under the conditions of 80~100 DEG C, extract 1.0~2.0H, the spearmint essential oil is made；It is preferred that
To carry out Dynamic Extraction under the conditions of 90 DEG C, 1.5H is extracted.
The Herba Menthae Haplocalycis volatile oil is extracted by peppermint and is obtained, and is made by following steps:
Peppermint is ground into the water that 8~12 times of amounts are added after coarse powder, the water of 10 times of amounts is preferably added, distills 7~9h, it is excellent
It is selected as distillation 8h, the Herba Menthae Haplocalycis volatile oil is made.Wherein, the water of 10 times of amounts refers to that the water of addition is peppermint weight (unit is gram)
10 times of volumes (unit is milliliter) water, for example, peppermint weight be N grams when, then 10N milliliters of water is added.
The probiotics bacterial powder is the active microbe powder as made from lactobacillus acidophilus and Bifidobacterium, passes through following steps system
:
S51, lactobacillus acidophilus and Bifidobacterium mixed bacteria are accessed in fluid nutrient medium by solid slope culture medium, in
20~26h is cultivated in 30 DEG C~45 DEG C constant temperature, is activated 2~3 times；It is preferably cultivated for 24 hours in 37 DEG C of constant temperature, activates 2~3 repeatedly
It is secondary；
S52, by activated pure culture with 2%~5% inoculum concentration, preferably 4% inoculum concentration is inoculated in MRS liquid
In culture medium, in 30 DEG C~45 DEG C constant temperature, expanded culture in preferably 37 DEG C of insulating boxs；
S53, the bacterium solution for expanding culture are centrifuged 10~20min, abandon at 4 DEG C~8 DEG C under the conditions of 5000~7000r/min
Supernatant is rinsed with sterile saline precipitate thereafter, and it is 0.8 × 10 that viable count, which is made,9~1.2 × 109The bacterium of cfu/mL is outstanding
Liquid；It preferably is centrifuged 15min under the conditions of 6 000r/min, it is 1.0 × 10 that viable count, which is made,9The bacteria suspension of cfu/mL；
It is added after protective agent in S54, bacteria suspension and keeps the temperature 10~50min in 65 DEG C~85 DEG C temperature, preferably in 75 DEG C
30min is kept the temperature in temperature.Wherein, the protective agent is the glycerol of the trehalose of 12%~20% (w/v), 4%~8% (w/v)
It is preferably the glycerol and 0.14% (v/ of the trehalose of 16% (w/v), 6% (w/v) with the gelatin of 0.1%~0.2% (v/v)
V) gelatin.For example, bacteria suspension be X milliliters when, protectant additive amount is preferred are as follows: 16%*X grams of trehalose, 6%*X grams it is sweet
Oil, 0.14%*X milliliters of gelatin.
S55, it is dried using low temperature concentrated spray dry technology, leaving air temp is 40 DEG C~65 DEG C, inlet air temperature
It is 120 DEG C~150, the active microbe powder that total solid content is 20%~40%, i.e., the described probiotics bacterial powder is made.This implementation
135 DEG C of inlet air temperature, the active microbe powder that total solid content is 30% is made in example preferably 50 DEG C of leaving air temp.
Embodiment 2
The halitosis lozenge of the present embodiment, specification are every 0.5g comprising 8 parts of spearmint essential oil, dandelion extracting solution
8 parts of powder, honeysuckle extract 8 parts of powder, 8 parts of Herba Menthae Haplocalycis volatile oil, 3 parts of Baical Skullcap root P.E, 12 parts of probiotics bacterial powder, diluent
46.7 parts, 0.3 part of excipient.Wherein, the number of above-mentioned each component is parts by weight, and main ingredient is spearmint essential oil, dandelion mentions
Liquid powder, honeysuckle is taken to extract powder, Herba Menthae Haplocalycis volatile oil, Baical Skullcap root P.E, probiotics bacterial powder, weight accounting is 50%, auxiliary
Expect diluent and excipient weight accounting 50%.
Preparation method is the same as embodiment 1.
Embodiment 3
The halitosis lozenge of the present embodiment, specification are every 0.5g comprising 12 parts of spearmint essential oil, dandelion extracting solution
3 parts of powder, honeysuckle extract 12 parts of powder, 12 parts of Herba Menthae Haplocalycis volatile oil, 8 parts of Baical Skullcap root P.E, 8 parts of probiotics bacterial powder, diluent
54.2 parts, 0.8 part of excipient.Wherein, the number of above-mentioned each component is parts by weight, and main ingredient is spearmint essential oil, dandelion mentions
Liquid powder, honeysuckle is taken to extract powder, Herba Menthae Haplocalycis volatile oil, Baical Skullcap root P.E, probiotics bacterial powder, weight accounting is 50%, auxiliary
Expect diluent and excipient weight accounting 50%.
Preparation method is the same as embodiment 1.
Embodiment 4
The halitosis lozenge of the present embodiment, specification are every 0.5g comprising 10 parts of spearmint essential oil, dandelion extracting solution
3 parts of powder, honeysuckle extract 8 parts of powder, 9.3 parts of Herba Menthae Haplocalycis volatile oil, 5 parts of Baical Skullcap root P.E, 10 parts of probiotics bacterial powder, diluent
45 parts, 0.3 part of excipient.Wherein, the number of above-mentioned each component is parts by weight, and main ingredient is spearmint essential oil, dandelion extraction
Liquid powder, honeysuckle extract powder, Herba Menthae Haplocalycis volatile oil, Baical Skullcap root P.E, probiotics bacterial powder, and weight accounting is 50%, auxiliary material
Diluent and excipient weight accounting 50%.
Preparation method is the same as embodiment 1.
Embodiment 5
The halitosis lozenge of the present embodiment, specification are every 0.5g comprising 13.8 parts of spearmint essential oil, dandelion are extracted
5 parts of liquid powder, honeysuckle extract 10 parts of powder, 12 parts of Herba Menthae Haplocalycis volatile oil, 5 parts of Baical Skullcap root P.E, 10 parts of probiotics bacterial powder, dilution
55 parts of agent, 0.8 part of excipient.Wherein, the number of above-mentioned each component is parts by weight, and main ingredient is spearmint essential oil, dandelion mentions
Liquid powder, honeysuckle is taken to extract powder, Herba Menthae Haplocalycis volatile oil, Baical Skullcap root P.E, probiotics bacterial powder, weight accounting is 50%, auxiliary
Expect diluent and excipient weight accounting 50%.
Preparation method is the same as embodiment 1.
Halitosis lozenge of the invention, mouth containing use, each one, 3~4 times on the one.
Application examples:
The halitosis patient that selection 200 is made a definite diagnosis carries out clinical observation, wherein male 121, and women 79, the age 15~50
Year.Halitosis patient is divided into 5 groups at random, each group of people is 40 people.
Every group of patient takes the halitosis lozenge of 1~embodiment of embodiment 5 respectively, and 3-4 times daily, 1 tablet once, and 7 days are 1
The course for the treatment of observes the healing of halitosis patient and alleviates situation after taking 1 course for the treatment of.Its data statistics is as follows:
| Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 | Embodiment 6 | |
| Cure number | 33 | 30 | 27 | 29 | 25 | 26 |
| Alleviate number | 7 | 10 | 10 | 8 | 14 | 12 |
The result shows that halitosis lozenge of the invention has apparent curative effect for treatment halitosis, and above-mentioned healing case exists
Subsequent different time after two months carries out follow-up, does not recur.
Although being disclosed by above embodiments to the present invention, the scope of the invention is not limited to this,
Under conditions of present inventive concept, above each component can with technical field personnel understand similar or equivalent element come
Replacement.
Claims (9)
1. a kind of halitosis lozenge, which is characterized in that it is prepared by the component of following parts by weight:
Powder, Herba Menthae Haplocalycis volatile oil, Baical Skullcap root P.E, prebiotic is extracted containing spearmint essential oil, dandelion extracting solution powder, honeysuckle
45~55 parts of the main ingredient of bacterium bacterium powder；
45~55 parts of diluent；
0.3~0.8 part of excipient.
2. halitosis lozenge as described in claim 1, which is characterized in that it is prepared by the component of following parts by weight:
Powder, Herba Menthae Haplocalycis volatile oil, Baical Skullcap root P.E, prebiotic is extracted containing spearmint essential oil, dandelion extracting solution powder, honeysuckle
50 parts of the main ingredient of bacterium bacterium powder；
49.5 parts of diluent；
0.5 part of excipient.
3. the halitosis lozenge as described in claims 1 or 2 any bar, which is characterized in that the main ingredient includes following parts by weight
Each component:
8~12 parts of spearmint essential oil；
3~8 parts of dandelion extracting solution powder；
Honeysuckle extracts 8~12 parts of powder；
8~12 parts of Herba Menthae Haplocalycis volatile oil；
3~8 parts of Baical Skullcap root P.E；
8~12 parts of probiotics bacterial powder.
4. halitosis lozenge as claimed in claim 2, which is characterized in that the main ingredient is grouped by each group of following parts by weight
At:
10 parts of spearmint essential oil；
5 parts of dandelion extracting solution powder；
Honeysuckle extracts 10 parts of powder；
10 parts of Herba Menthae Haplocalycis volatile oil；
5 parts of Baical Skullcap root P.E；
10 parts of probiotics bacterial powder.
5. halitosis lozenge as described in claim 1, which is characterized in that the probiotics bacterial powder is by lactobacillus acidophilus and bifid
Active microbe powder made from bacillus.
6. halitosis lozenge as described in claim 1, which is characterized in that the diluent includes cornstarch, dextrin, mannitol
One of or it is a variety of.
7. halitosis lozenge as described in claim 1, which is characterized in that the diluent is by cornstarch, dextrin, mannitol group
At weight ratio 3:1:1.
8. halitosis lozenge as described in claim 1, which is characterized in that the excipient is magnesium stearate.
9. halitosis lozenge as described in claim 1, which is characterized in that the halitosis lozenge is made of pressed disc method, and every halitosis contains
The specification of piece is 0.5g.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810013642.3A CN110013501A (en) | 2018-01-07 | 2018-01-07 | Halitosis lozenge |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810013642.3A CN110013501A (en) | 2018-01-07 | 2018-01-07 | Halitosis lozenge |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110013501A true CN110013501A (en) | 2019-07-16 |
Family
ID=67187304
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810013642.3A Pending CN110013501A (en) | 2018-01-07 | 2018-01-07 | Halitosis lozenge |
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| Country | Link |
|---|---|
| CN (1) | CN110013501A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113082149A (en) * | 2021-04-28 | 2021-07-09 | 宋颖鹰 | Plant herbal probiotic buccal tablet and preparation method thereof |
| CN115590900A (en) * | 2022-10-10 | 2023-01-13 | 湖南循力源口腔疾病研究院有限公司（Cn） | Application of traditional Chinese medicine volatile oil in substances for preventing and treating halitosis |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105685342A (en) * | 2016-02-18 | 2016-06-22 | 江苏微康生物科技有限公司 | Probiotic buccal tablet and preparation method thereof |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105685342A (en) * | 2016-02-18 | 2016-06-22 | 江苏微康生物科技有限公司 | Probiotic buccal tablet and preparation method thereof |
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| Title |
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| 尚慧敏等: "口腔除臭含片的研制 ", 《吉林农业科技学院学报》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113082149A (en) * | 2021-04-28 | 2021-07-09 | 宋颖鹰 | Plant herbal probiotic buccal tablet and preparation method thereof |
| CN115590900A (en) * | 2022-10-10 | 2023-01-13 | 湖南循力源口腔疾病研究院有限公司（Cn） | Application of traditional Chinese medicine volatile oil in substances for preventing and treating halitosis |
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