CN109620769A - A kind of acne eliminating cream of inhibiting bacteria and diminishing inflammation and preparation method thereof - Google Patents
A kind of acne eliminating cream of inhibiting bacteria and diminishing inflammation and preparation method thereof Download PDFInfo
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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Abstract
The invention belongs to cosmetic fields, and in particular to a kind of acne eliminating cream of inhibiting bacteria and diminishing inflammation and preparation method thereof.The acne eliminating cream of inhibiting bacteria and diminishing inflammation provided by the invention, including following component and its mass fraction: 5-8 parts of pot marigold, 1-3 parts of sanchi flower, 3-5 parts of Chinese trumpet creeper, 3-5 parts of lotus seeds pollen, 0.3-0.8 parts of rosewood essential oil, 1-3 parts of caryophyllus oil, 0.5-1.0 parts of citric acid, 3-5 parts of moisturizer, 5-7 parts of emulsifier, 3-5 parts of thickener, 40-60 parts of water.Acne eliminating cream provided by the invention does not add any preservative, will not generate any toxic side effect to skin, moreover, acne eliminating cream provided by the invention has good inhibiting bacteria and diminishing inflammation effect, can also remove acne print, have the function of keeping skin tender smooth.
Description
Technical field
The invention belongs to cosmetic fields, and in particular to a kind of acne eliminating cream of inhibiting bacteria and diminishing inflammation and preparation method thereof.
Background technique
Acne namely acne are a kind of chronic inflammatory skins of pilosebaceous unit, occur mainly to divide with sebum
It is closely related to secrete the factors such as excessive, pilosebaceous duct blocking, bacterium infection and inflammatory reaction.It adolesces in descendant's body
The level of androgen especially testosterone increases rapidly, and sebaceous glands is promoted to develop and generate a large amount of sebums.Pilosebaceous follicle is led simultaneously
The dyskeratosis of pipe causes catheter blockage, and dyssebacia forms horn plug, that is, micro mist thorn.Multiple-microorganism is especially in hair follicle
It is propionibacterium acnes mass propagation, the lipase that propionibacterium acnes generate decomposes sebum and generates free fatty acid, while chemotactic
Inflammatory cell and medium, finally induce and aggravate inflammatory reaction.Meeting nature mitigates up to recovery from illness generally after puberty, still,
Sometimes acne is very serious, not easy-clear, can distribute to back, on leg etc..
In recent years, occur the skin care item of many anti-acnes both at home and abroad, there is good anti-acne function if aloe Deacne pack
Effect.In addition to this, occur various types of acne eliminating creams in the market, but existing acne eliminating cream be mostly by adding arbutin,
Ginkgo etc. is used as active constituent, then adds some thickeners, preservative etc. and be prepared.But it obtained in this way dispels
The generally existing storage stability of acne frost is poor, the unconspicuous disadvantage of effect, moreover, the active constituent of this acne eliminating cream addition is relatively more high
It is expensive, cause the phenomenon that acne eliminating cream is at high cost, and common people can not consume.
Chinese patent application CN108096090A discloses a kind of acne eliminating cream and preparation method thereof, which utilizes tea tree
Essential oil is combined with base oil, can effectively be killed or be inhibited the microbial reproduction in product, prevent acne eliminating cream putrid and deteriorated,
Avoid in use skin being caused to infect, generate stimulation, still, the acne eliminating cream can not fully erased acne print, moreover, at
This is higher, and preparation process is more complicated.
Chinese patent application CN108653111A discloses a kind of acne eliminating cream and preparation method thereof, and the acne eliminating cream includes Huang
Coptis extract, Radix Arnebiae extract, loquat-leaf extract, Ramulus et Folium Spiraeae Salicifoliae extract have anti-acne using natural plant extracts compatibility
Effect is good, quick, the effect of preventing from scar.However, the acquisition process of these extracts is an extremely complex process, institute
The extract obtained is at high price, and therefore, the cost of acne eliminating cream is very high, and common audient is difficult to bear, moreover, the acne eliminating cream can be to skin
Skin generates certain stimulation.
In summary, the generally existing preparation process of acne eliminating cream in the prior art is complicated, at high cost, is easy to cause skin
Certain stimulation is easy the disadvantages of recurring.
Summary of the invention
In view of the defects existing in the prior art, the object of the present invention is to provide a kind of acne eliminating cream of inhibiting bacteria and diminishing inflammation and its preparations
Method.The acne eliminating cream of inhibiting bacteria and diminishing inflammation provided by the invention, have it is at low cost, can effective anti-acne, do not stay pockmark, it is stingless to skin
Sharp feature, moreover, the acne eliminating cream of inhibiting bacteria and diminishing inflammation produced by the present invention, preparation method is simple, uneasy to recur.
To achieve the goals above, the technical solution of the present invention is as follows:
A kind of acne eliminating cream of inhibiting bacteria and diminishing inflammation, including following component and its mass fraction: 5-8 parts of pot marigold, sanchi flower 1~3
Part, 3~5 parts of Chinese trumpet creeper, 3~5 parts of lotus seeds pollen, 0.3~0.8 part of rosewood essential oil, 1~3 part of caryophyllus oil, citric acid 0.5-
1.0 parts, 3~5 parts of moisturizer, 5~7 parts of emulsifier, 3~5 parts of thickener, 40~60 parts of water.
Preferably, the acne eliminating cream of the inhibiting bacteria and diminishing inflammation is made of following component and its mass fraction: 6 parts of pot marigold, Radix Notoginseng
Spend 2 parts, 4 parts of Chinese trumpet creeper, 4 parts of lotus seeds pollen, 0.5 part of rosewood essential oil, 2 parts of caryophyllus oil, 0.8 part of citric acid, 4 parts of moisturizer,
6 parts of emulsifier, 4 parts of thickener, 50 parts of water.
Preferably, the moisturizer is made of trehalose and shea butter 1~3:5~7 in mass ratio.
It is further preferred that the moisturizer is made of trehalose and shea butter 2:5 in mass ratio.
Preferably, the emulsifier is by beeswax and isopropyl palmitate 5~10:18~24 in mass ratio.
It is further preferred that the emulsifier is made of beeswax and isopropyl palmitate 7:20 in mass ratio.
Preferably, the thickener is made of aluminum magnesium silicate and xanthan gum 3~5:7~10 in mass ratio.
It is further preferred that the thickener is made of aluminum magnesium silicate and xanthan gum 4:9 in mass ratio.
The present invention also provides the preparation method of the acne eliminating cream of the inhibiting bacteria and diminishing inflammation, operating procedure is as follows:
S1, by pot marigold, sanchi flower, Chinese trumpet creeper sunning after drying, is crushed, crosses 500 meshes, be then added to body
In the ethanol solution that fraction is 75%, refluxing extraction is concentrated under reduced pressure, obtains concentrate；
S2, concentrate obtained by step S1 crossed to D101 macroporous resin column, and collects eluent to colourless with ethanol elution,
It depressurizes, be concentrated to give mixture I；
S3,60-80 DEG C is heated water to, mixture I obtained by step S2, lotus seeds pollen and moisturizer is added, stirs at low speed
10-20min obtains mixtures II until being uniformly mixed；
S4, emulsifier is added into mixtures II obtained by step S3, keeps 60-80 DEG C of temperature, stirs at low speed 10-
15min obtains mixtures III to being uniformly mixed；
S5, temperature is reduced to 45-55 DEG C, is added thickener into mixtures III obtained by step S4, rosewood essential oil,
Caryophyllus oil stirs at low speed 15-25min, until be uniformly mixed, it, then will be warm with the pH value of citric acid adjusting mixed liquor to 6.8-7.2
Degree be down to 30-40 DEG C, vacuumize, continue stir 10-20min, filtering and discharging to get.
Preferably, mixing speed when stirring at low speed in described step S3, S4, S5 is 150-300r/min.
Pot marigold, biennial herbaceous plant are generally grown on mild, nice and cool weather, are rich in vitamin A and vitamin C,
It can prevent pigementation, promote skin gloss and elasticity, delaying senility avoids the raw wrinkle of skin relaxation, and petal has beauty,
The effect of antibacterial anti-inflammatory.
Sanchi flower, herbaceos perennial are generally grown on environment cool in summer and warm in winter, are rich in notoginsenoside, and saponin(e pair
The effect of central nervous system has certain inhibiting effect, shows as calmness, calms the nerves, sanchi flower has heat-clearing, calming the liver, decompression
Function.Has the function of good anti-acne in cosmetics except sore.
Chinese trumpet creeper, perennial bejuco, happiness is positive, slightly shade tolerant, likes warm and moist weather, rich in flavonoids and has
The substances such as machine acid have broken stasis of blood cold dispelling, and cool blood goes wind action, also has certain treatment acne, and the postpartum stasis of blood is had a pain, wind pain body
Itch, the rubescent effect of the wind stasis of blood.
Lotus seeds pollen, be derived from lotus seeds spend in pistil, taste is dry and astringent, and warm-natured, Yu Xiaji is held, and is rich in multiple proteins, living
Property enzyme and flavone compound, there is the cool blood that clears away heart-fire, relieving heat toxin, disappear wet wind action of dispelling, for freckle, whelk and stomach disease
Disease has good therapeutic effect.
Rosewood essential oil is extracted from wild rosewood, and rosewood is the tree for originating in Amazon River basin
Wood is rich in linalool and a little nitre alkenes, the substances such as nerol, safety, nontoxic, nonirritant, Bu Huiyin in the essential oil of extraction
Allergic reaction is played, headache can be effectively eliminated.
Caryophyllus oil is that the dry flower of plant clove of myrtaceae is distilled resulting volatile oil, is yellowish or colourless
Clear and bright grease, not soluble in water, acrid-sweet flavor, extremely hot in nature are soluble in alcohol, have warm stomach, and the effect of warm kidney can also treat stomach cold
It is bitterly swollen.
In the present invention, while it being added to pot marigold, sanchi flower and Chinese trumpet creeper not only have inhibiting bacteria and diminishing inflammation effect, but also make
Preparation Method is simple, at low cost, can achieve good anti-acne effect.The present invention is found surprisingly that, by pot marigold, sanchi flower and icepro
Clouds flower is used in mixed way with lotus seeds pollen, can effectively remove acne print, keeps skin smooth fine and smooth.In addition, the present invention joined simultaneously
The inhibiting bacteria and diminishing inflammation effect of acne eliminating cream can be enhanced in rosewood essential oil and clove oil, so that anti-acne effect is more stable, moreover,
Both essential oils are used in mixed way, and can play antisepsis, do not need to add individual preservative again, will not generate thorn to skin
Swash reaction.
Compared with prior art, the advantages of acne eliminating cream of inhibiting bacteria and diminishing inflammation provided by the invention, is:
(1) acne eliminating cream of inhibiting bacteria and diminishing inflammation provided by the invention, preparation method is simple, moreover, raw material used is market
It is upper common, so that acne eliminating cream produced by the present invention is at low cost；
(2) acne eliminating cream of inhibiting bacteria and diminishing inflammation provided by the invention, while being added to pot marigold, sanchi flower, Chinese trumpet creeper and lotus seeds
Pollen has good inhibiting bacteria and diminishing inflammation effect；
(3) acne eliminating cream of inhibiting bacteria and diminishing inflammation provided by the invention does not add any preservative, rosewood essential oil and clove oil
Antisepsis can be played, and not will cause any stimulation to skin.
Specific embodiment
Purposes, technical schemes and advantages in order to better illustrate the present invention, below in conjunction with specific embodiment to this hair
It is bright to be described further, but following embodiment is not intended to restrict the invention, all and similar method or technique side of the invention
Case is within the scope of the present invention.
A kind of acne eliminating cream of the inhibiting bacteria and diminishing inflammation of embodiment 1
The acne eliminating cream of the inhibiting bacteria and diminishing inflammation is made of following component and its mass fraction: 5 parts of pot marigold, 1 part of sanchi flower,
3 parts of Chinese trumpet creeper, 3 parts of lotus seeds pollen, 0.3 part of rosewood essential oil, 1 part of caryophyllus oil, 0.5 part of citric acid, 3 parts of moisturizer, emulsifier 5
Part, 3 parts of thickener, 40 parts of water；
The moisturizer is made of trehalose and shea butter 1:5 in mass ratio；
The emulsifier is made of beeswax and isopropyl palmitate 5:18 in mass ratio；
The thickener is made of aluminum magnesium silicate and xanthan gum 3:7 in mass ratio.
The acne eliminating cream of the inhibiting bacteria and diminishing inflammation the preparation method comprises the following steps:
S1, by pot marigold, sanchi flower, Chinese trumpet creeper sunning after drying, is crushed, crosses 500 meshes, be then added to body
In the ethanol solution that fraction is 75%, refluxing extraction is concentrated under reduced pressure, obtains concentrate；
S2, concentrate obtained by step S1 crossed to D101 macroporous resin column, and collects eluent to colourless with ethanol elution,
It depressurizes, be concentrated to give mixture I；
S3,60 DEG C are heated water to, mixture I obtained by step S2, lotus seeds pollen and moisturizer is added, in 150r/min's
10min is stirred under revolving speed, until being uniformly mixed, obtains mixtures II；
S4, emulsifier is added into mixtures II obtained by step S3,60 DEG C of temperature is kept, under the revolving speed of 150r/min
10min is stirred to being uniformly mixed, obtains mixtures III；
S5, temperature is reduced to 45 DEG C, thickener, rosewood essential oil, cloves is added into mixtures III obtained by step S4
Oil stirs 15min under the revolving speed of 150r/min, until be uniformly mixed, adjusts the pH value of mixed liquor to 6.8, then with citric acid
Cool the temperature to 30 DEG C, vacuumize, continue stir 10min, filtering and discharging to get.
A kind of acne eliminating cream of the inhibiting bacteria and diminishing inflammation of embodiment 2
The acne eliminating cream of the inhibiting bacteria and diminishing inflammation is made of following component and its mass fraction: 8 parts of pot marigold, 3 parts of sanchi flower,
5 parts of Chinese trumpet creeper, 5 parts of lotus seeds pollen, 0.8 part of rosewood essential oil, 3 parts of caryophyllus oil, 1.0 parts of citric acid, 5 parts of moisturizer, emulsifier 7
Part, 5 parts of thickener, 60 parts of water；
The moisturizer is made of trehalose and shea butter 3:7 in mass ratio；
The emulsifier is made of beeswax and isopropyl palmitate 10:24 in mass ratio；
The thickener is made of aluminum magnesium silicate and xanthan gum 5:10 in mass ratio.
The acne eliminating cream of the inhibiting bacteria and diminishing inflammation the preparation method comprises the following steps:
S1, by pot marigold, sanchi flower, Chinese trumpet creeper sunning after drying, is crushed, crosses 500 meshes, be then added to body
In the ethanol solution that fraction is 75%, refluxing extraction is concentrated under reduced pressure, obtains concentrate；
S2, concentrate obtained by step S1 crossed to D101 macroporous resin column, and collects eluent to colourless with ethanol elution,
It depressurizes, be concentrated to give mixture I；
S3,80 DEG C are heated water to, mixture I obtained by step S2, lotus seeds pollen and moisturizer is added, in 300r/min's
20min is stirred under revolving speed, until being uniformly mixed, obtains mixtures II；
S4, emulsifier is added into mixtures II obtained by step S3,80 DEG C of temperature is kept, under the revolving speed of 300r/min
15min is stirred to being uniformly mixed, obtains mixtures III；
S5, temperature is reduced to 55 DEG C, thickener, rosewood essential oil, cloves is added into mixtures III obtained by step S4
Oil stirs 25min under the revolving speed of 300r/min, until be uniformly mixed, adjusts the pH value of mixed liquor to 7.2, then with citric acid
Cool the temperature to 40 DEG C, vacuumize, continue stir 20min, filtering and discharging to get.
A kind of acne eliminating cream of the inhibiting bacteria and diminishing inflammation of embodiment 3
The acne eliminating cream of the inhibiting bacteria and diminishing inflammation is made of following component and its mass fraction: 6 parts of pot marigold, 2 parts of sanchi flower,
4 parts of Chinese trumpet creeper, 4 parts of lotus seeds pollen, 0.5 part of rosewood essential oil, 2 parts of caryophyllus oil, 0.8 part of citric acid, 4 parts of moisturizer, emulsifier 6
Part, 4 parts of thickener, 50 parts of water；
The moisturizer is made of trehalose and shea butter 2:5 in mass ratio；
The emulsifier is made of beeswax and isopropyl palmitate 7:20 in mass ratio；
The thickener is made of aluminum magnesium silicate and xanthan gum 4:9 in mass ratio.
The acne eliminating cream of the inhibiting bacteria and diminishing inflammation the preparation method comprises the following steps:
S1, by pot marigold, sanchi flower, Chinese trumpet creeper sunning after drying, is crushed, crosses 500 meshes, be then added to body
In the ethanol solution that fraction is 75%, refluxing extraction is concentrated under reduced pressure, obtains concentrate；
S2, concentrate obtained by step S1 crossed to D101 macroporous resin column, and collects eluent to colourless with ethanol elution,
It depressurizes, be concentrated to give mixture I；
S3,70 DEG C are heated water to, mixture I obtained by step S2, lotus seeds pollen and moisturizer is added, in 200r/min's
15min is stirred under revolving speed, until being uniformly mixed, obtains mixtures II；
S4, emulsifier is added into the resulting mixtures II of step S3,70 DEG C of temperature is kept, in the revolving speed of 200r/min
Lower stirring 12min obtains mixtures III to being uniformly mixed；
S5, temperature is reduced to 50 DEG C, thickener, rosewood essential oil, fourth is added into the resulting mixtures III of step S4
Sesame oil stirs 20min under the revolving speed of 200r/min, until be uniformly mixed, adjusts the pH value of mixed liquor to 7.0, so with citric acid
After cool the temperature to 35 DEG C, vacuumize, continue stir 15min, filtering and discharging to get.
A kind of acne eliminating cream of comparative example 1
The acne eliminating cream is made of following component and its mass fraction: 6 parts of pot marigold, 4 parts of Chinese trumpet creeper, and 4 parts of lotus seeds pollen,
0.5 part of rosewood essential oil, 2 parts of caryophyllus oil, 0.8 part of citric acid, 4 parts of moisturizer, 6 parts of emulsifier, 4 parts of thickener, 50 parts of water；Institute
Moisturizer is stated to be made of trehalose and shea butter 2:5 in mass ratio；The emulsifier presses matter by beeswax and isopropyl palmitate
Amount is formed than 7:20；The thickener is made of aluminum magnesium silicate and xanthan gum 4:9 in mass ratio.
The preparation method of the acne eliminating cream is similar to Example 3.
Difference with embodiment 3 is, sanchi flower is not included in comparative example 1.
A kind of acne eliminating cream of comparative example 2
The acne eliminating cream is made of following component and its mass fraction: 6 parts of pot marigold, 2 parts of sanchi flower, and 4 parts of Chinese trumpet creeper, lotus
4 parts of sub- pollen, 2 parts of caryophyllus oil, 0.8 part of citric acid, 4 parts of moisturizer, 6 parts of emulsifier, 4 parts of thickener, 50 parts of water；The moisturizing
Agent is made of trehalose and shea butter 2:5 in mass ratio；The emulsifier is by beeswax and isopropyl palmitate in mass ratio 7:
20 compositions；The thickener is made of aluminum magnesium silicate and xanthan gum 4:9 in mass ratio.
The preparation method of the acne eliminating cream is similar to Example 3.
Difference with embodiment 3 is, rosewood essential oil is not included in comparative example 2.
A kind of acne eliminating cream of comparative example 3
The acne eliminating cream is made of following component and its mass fraction: 6 parts of pot marigold, 2 parts of sanchi flower, and 4 parts of Chinese trumpet creeper, lotus
4 parts of sub- pollen, 0.5 part of rosewood essential oil, 2 parts of caryophyllus oil, 0.8 part of citric acid, 4 parts of moisturizer, 6 parts of emulsifier, thickener 4
Part, 50 parts of water；The moisturizer is made of trehalose and shea butter 1:1 in mass ratio；The emulsifier is by beeswax and palm
Isopropyl propionate 7:20 in mass ratio composition；The thickener is made of aluminum magnesium silicate and xanthan gum 4:9 in mass ratio.
The preparation method of the acne eliminating cream is similar to Example 3.
Difference with embodiment 3 is that the moisturizer in comparative example 3 is by trehalose and shea butter 1:1 group in mass ratio
At.
A kind of acne eliminating cream of comparative example 4
The acne eliminating cream is made of following component and its mass fraction: 6 parts of pot marigold, 2 parts of sanchi flower, and 4 parts of Chinese trumpet creeper, lotus
4 parts of sub- pollen, 0.5 part of rosewood essential oil, 2 parts of caryophyllus oil, 0.8 part of citric acid, 4 parts of moisturizer, 6 parts of emulsifier, thickener 4
Part, 50 parts of water；The moisturizer is made of trehalose and shea butter 2:5 in mass ratio；The emulsifier is by beeswax and palm
Isopropyl propionate 1:1 in mass ratio composition；The thickener is made of aluminum magnesium silicate and xanthan gum 4:9 in mass ratio.
The preparation method of the acne eliminating cream is similar to Example 3.
Difference with embodiment 3 is that the emulsifier in comparative example 4 is by beeswax and isopropyl palmitate 1:1 in mass ratio
Composition.
A kind of acne eliminating cream of comparative example 5
The acne eliminating cream is made of following component and its mass fraction: 6 parts of pot marigold, 2 parts of sanchi flower, and 4 parts of Chinese trumpet creeper, lotus
4 parts of sub- pollen, 0.5 part of rosewood essential oil, 2 parts of caryophyllus oil, 0.8 part of citric acid, 4 parts of moisturizer, 6 parts of emulsifier, thickener 4
Part, 50 parts of water；The moisturizer is made of trehalose and shea butter 2:5 in mass ratio；The emulsifier is by beeswax and palm
Isopropyl propionate 7:20 in mass ratio composition；The thickener is made of aluminum magnesium silicate and xanthan gum 1:1 in mass ratio.
The preparation method of the acne eliminating cream is similar to Example 3；
Difference with embodiment 3 is that the thickener in comparative example 5 is by aluminum magnesium silicate and xanthan gum 1:1 group in mass ratio
At.
The test of 1 irritation of experimental example
1. experimental material: the acne eliminating cream of inhibiting bacteria and diminishing inflammation made from embodiment 1-3；Acne eliminating cream made from comparative example 1-5.
2. experimental subjects: using the BALB/c mouse of 4-6 week old as research object, 80 mouse being taken to be divided into 8 groups, every group
10.
3. experimental method: before experiment starts, under the premise of not damaging mouse skin, by the dorsal body setae of its back backbone two sides
It wipes off, unhairing range is 2cm × 2cm.Laboratory sample 1g is taken to be applied on the skin of side, application area is 1.5cm × 1.5cm,
It is covered with two layers of gauze and one layer of glassine paper, then is fixed with medical adhesive tape, other side skin makees same treatment, as blank pair
According to.The variation of two sides skin is observed for 24 hours, when 48h respectively.
4. experimental result: final result discovery, mouse smear the skin of laboratory sample and do not smear the skin of laboratory sample
No significant difference illustrates to dispel made from the acne eliminating cream and comparative example 1-5 of inhibiting bacteria and diminishing inflammation made from embodiment 1-3 provided by the invention
Acne frost is nonirritant to skin.
The test of 2 bacteriostasis property of experimental example
1. experimental material: the acne eliminating cream of inhibiting bacteria and diminishing inflammation made from embodiment 1-3；Acne eliminating cream made from comparative example 1-5.
2. experimental subjects: Escherichia coli, staphylococcus aureus and pseudomonas aeruginosa.
3. experimental method: using the bacteriostasis property of paper disk method detection test specimen, in an aseptic environment, the circle scraps of paper being soaked
Afterwards, test specimen is picked respectively, and the circle scraps of paper are sticked to respectively then and fill Escherichia coli, pseudomonas aeruginosa, golden yellow Portugal
Observed and recorded on the agar plate of grape coccus, after overnight incubation its antibacterial circle diameter size (as antibacterial circle diameter >=10mm,
Skin care item are antibacterial effectively, and as antibacterial circle diameter < 10mm, skin care item are antibacterial invalid).
4. experimental result: specific experiment the results are shown in Table 1.
Inhibition situation of 1 experimental material of table to different strain
As shown in Table 1, the antibacterial circle diameter of the acne eliminating cream of inhibiting bacteria and diminishing inflammation made from 1-3 of the embodiment of the present invention reaches 17mm
More than, there is good fungistatic effect, wherein acne eliminating cream made from embodiment 3 exists to the antibacterial circle diameter of three kinds of bacteriums
20mm or more is highly preferred embodiment of the present invention, and in comparative example 1-5, bacteriostasis property is unobvious, is not added with flower in comparative example 2
Pear wood essential oil, therefore, bacteriostasis property is worst.
The test of 3 anti-acne effect of experimental example
1. experimental material: the acne eliminating cream of inhibiting bacteria and diminishing inflammation made from embodiment 1-3；Acne eliminating cream made from comparative example 1-5.
2. experimental subjects: choose the age at 18-25 years old the volunteer with whelk 160 on the face, be randomly divided into 8 groups,
Every group of 20 people.
3. experimental method: volunteer is washed one's face with clear water daily, then smears inhibiting bacteria and diminishing inflammation made from embodiment 1-3 respectively
Acne eliminating cream made from acne eliminating cream and comparative example 1-5, sooner or later each to smear primary, 20 days are 1 period.
Curative effect determinate standard:
(1) effective: after smearing 1 period, whelk is completely disappeared, and no acne print generates, and does not recur in 1 year；
(2) effectively: after smearing 1 period, the symptoms were significantly improved for whelk, and after 2 courses for the treatment of, whelk is completely disappeared, and 1
It is not recurred in year；
(3) invalid: after smearing 1-2 period, whelk is without being clearly better, or even has exacerbation trend.
4. experimental result: specific experiment the results are shown in Table 2.
The anti-acne effect of 2 different experimental materials of table
| Laboratory sample | Number/people | Effective/people | Effectively/people | In vain/people | Total effective rate/% |
| Example 1 group | 20 | 16 | 2 | 2 | 90 |
| 2 groups of embodiment | 20 | 17 | 1 | 2 | 90 |
| 3 groups of embodiment | 20 | 18 | 1 | 1 | 95 |
| 1 group of comparative example | 20 | 6 | 1 | 13 | 35 |
| 2 groups of comparative example | 20 | 7 | 2 | 11 | 45 |
| 3 groups of comparative example | 20 | 9 | 2 | 9 | 55 |
| 4 groups of comparative example | 20 | 9 | 3 | 8 | 60 |
| 5 groups of comparative example | 20 | 11 | 2 | 7 | 65 |
As shown in Table 2, acne eliminating cream made from 1-3 of embodiment of the present invention group is after smearing 1-2 period, and volunteer is on the face
Whelk can completely disappear, preventing from scar, and will not recur, best with the anti-acne effect of embodiment 3, be of the invention best
Embodiment.In comparative example 1-5 group, anti-acne effect is significantly lower than embodiment 1-3 group, worst with comparative example 1-2 group effect, further
It demonstrates sanchi flower and rosewood essential oil and is mutually cooperateed with other components, anti-acne effect can be significantly improved.
Finally it should be noted that the above embodiments are merely illustrative of the technical solutions of the present invention rather than protects to the present invention
The limitation of range, although elaborating referring to preferred embodiment to the present invention, those skilled in the art should be managed
Solution, can with modification or equivalent replacement of the technical solution of the present invention are made, without departing from technical solution of the present invention essence and
Range.
Claims (10)
1. a kind of acne eliminating cream of inhibiting bacteria and diminishing inflammation, which is characterized in that including following component and its mass fraction: 5-8 parts of pot marigold, three
Seven spend 1~3 part, and 3~5 parts of Chinese trumpet creeper, 3~5 parts of lotus seeds pollen, 0.3~0.8 part of rosewood essential oil, 1~3 part of caryophyllus oil, lemon
It is 0.5-1.0 parts sour, 3~5 parts of moisturizer, 5~7 parts of emulsifier, 3~5 parts of thickener, 40~60 parts of water.
2. the acne eliminating cream of inhibiting bacteria and diminishing inflammation as described in claim 1, which is characterized in that by following component and its mass parts array
At: 6 parts of pot marigold, 2 parts of sanchi flower, 4 parts of Chinese trumpet creeper, 4 parts of lotus seeds pollen, 0.5 part of rosewood essential oil, 2 parts of clove oil, lemon
0.8 part, 4 parts of moisturizer, 6 parts of emulsifier, 4 parts of thickener, 50 parts of water of acid.
3. the acne eliminating cream of inhibiting bacteria and diminishing inflammation as claimed in claim 1 or 2, which is characterized in that the moisturizer is by trehalose and cream
Wooden fruit oil 1~3:5 in mass ratio~7 composition.
4. the acne eliminating cream of inhibiting bacteria and diminishing inflammation as claimed in claim 3, which is characterized in that the moisturizer is by trehalose and the wooden fruit of cream
Oil 2:5 in mass ratio composition.
5. the acne eliminating cream of inhibiting bacteria and diminishing inflammation as claimed in claim 1 or 2, which is characterized in that the emulsifier is by beeswax and palm
Isopropyl propionate 5~10:18 in mass ratio~24 composition.
6. the acne eliminating cream of inhibiting bacteria and diminishing inflammation as claimed in claim 5, which is characterized in that the emulsifier is different by beeswax and palmitinic acid
Propyl ester 7:20 in mass ratio composition.
7. the acne eliminating cream of inhibiting bacteria and diminishing inflammation as claimed in claim 1 or 2, which is characterized in that the thickener by aluminum magnesium silicate and
Xanthan gum 3~5:7 in mass ratio~10 composition.
8. the acne eliminating cream of inhibiting bacteria and diminishing inflammation as claimed in claim 7, which is characterized in that the thickener is by aluminum magnesium silicate and Han Sheng
Glue 4:9 in mass ratio composition.
9. a kind of preparation method of such as acne eliminating cream of the described in any item inhibiting bacteria and diminishing inflammations of claim 1-8, which is characterized in that operation
Steps are as follows:
S1, by pot marigold, sanchi flower, Chinese trumpet creeper sunning after drying, is crushed, crosses 500 meshes, is then added to volume point
Number is in 75% ethanol solution, refluxing extraction is concentrated under reduced pressure, obtains concentrate；
S2, concentrate obtained by step S1 crossed to D101 macroporous resin column, and with ethanol elution to colourless, collects eluent, decompression,
It is concentrated to give mixture I；
S3,60-80 DEG C is heated water to, mixture I obtained by step S2, lotus seeds pollen and moisturizer is added, stirs at low speed 10-
20min obtains mixtures II until being uniformly mixed；
S4, emulsifier is added into mixtures II obtained by step S3, keeps 60-80 DEG C of temperature, stirs at low speed 10-15min extremely
It is uniformly mixed, obtains mixtures III；
S5, temperature is reduced to 45-55 DEG C, thickener, rosewood essential oil, fourth is added into the resulting mixtures III of step S4
Sesame oil stirs at low speed 15-25min, until being uniformly mixed, with the pH value of citric acid adjusting mixed liquor to 6.8-7.2, then by temperature
Be reduced to 30-40 DEG C, vacuumize, continue stir 10-20min, filtering and discharging to get.
10. the preparation method of the acne eliminating cream of inhibiting bacteria and diminishing inflammation as claimed in claim 9, which is characterized in that the step S3, S4,
Mixing speed when stirring at low speed in S5 is 150-300r/min.
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| CN201811469850.0A CN109620769A (en) | 2018-12-04 | 2018-12-04 | A kind of acne eliminating cream of inhibiting bacteria and diminishing inflammation and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110192993A (en) * | 2019-05-12 | 2019-09-03 | 广州芊舟生物科技有限公司 | A kind of plant source skin repair frost and preparation method thereof |
| CN112587449A (en) * | 2020-11-24 | 2021-04-02 | 张益丽 | Natural plant aromatic coating balm and preparation method and application thereof |
-
2018
- 2018-12-04 CN CN201811469850.0A patent/CN109620769A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110192993A (en) * | 2019-05-12 | 2019-09-03 | 广州芊舟生物科技有限公司 | A kind of plant source skin repair frost and preparation method thereof |
| CN112587449A (en) * | 2020-11-24 | 2021-04-02 | 张益丽 | Natural plant aromatic coating balm and preparation method and application thereof |
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Application publication date: 20190416 |