CN108451889A - A kind of probiotics antiallergy repair cream - Google Patents
A kind of probiotics antiallergy repair cream Download PDFInfo
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- CN108451889A CN108451889A CN201810647930.4A CN201810647930A CN108451889A CN 108451889 A CN108451889 A CN 108451889A CN 201810647930 A CN201810647930 A CN 201810647930A CN 108451889 A CN108451889 A CN 108451889A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/925—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of animal origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9771—Ginkgophyta, e.g. Ginkgoaceae [Ginkgo family]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
Abstract
The invention belongs to skin care fields, disclose a kind of probiotics antiallergy repair cream, which is composed of the following raw materials by weight：45 parts of stearic acid, 35 parts of octadecyl alcolol, 58 parts of isopropyl palmitate, 23 parts of lanolin, 24 parts of saualane, 0.1 0.15 parts of methyl hydroxybenzoate, 0.03 0.05 parts of propylben, 35 parts of white oil, 0.5 1 parts of olive oil, 5 10 parts of glycerine, 0.3 0.5 parts of triethanolamine, 12 parts of Chinese medicine fermented liquid, 0.3 0.5 parts of essence, distilled water to 100.The present invention is by will have the Chinese medicine of antibacterial anti-inflammatory and other effects to extract, and probiotics is added in extracting solution and is fermented, obtain the Chinese medicine fermented liquid rich in probiotics, it is applied in the preparation of repair cream, the effect of repair cream can be enhanced, acts on, improve skin water holding capacity, enhancing resisting skin allergy, anti-infectious ability and skin itself immunocompetence.
Description
Technical field
The present invention relates to technical field of skin care, and in particular to a kind of probiotics antiallergy repair cream.
Background technology
Sensitive skin is a kind of problem skin, susceptible by extraneous contact and to generate scratchy, red and swollen, twitch, blanching
Etc. symptoms, or even it is in static reaction that the symptom that has, which is, makes one not discovering.The self-protection defence technical ability of sensitive skin is weaker,
It is easy stimulated and causes skin sensitivity reaction, needed on selection cosmetics with caution, the production of the irritations such as essential oil, salicylic acid, tartaric acid
Product are intended to avoid, Chinese patent《A kind of black fruit fructus lycii whitening and moisturizing smoothing toner and preparation method of smoothing toner and preparation method thereof》(patent publication No.：
CN103565728A a kind of skin softening that the seaweed extracted liquor extracting seaweed using probiotics fermention is prepared as primary raw material) is disclosed
Water has the function of replenishing water and preserving moisture, skin care, patent《A kind of anti-anaphylaxis reason skin frost and preparation method thereof》(patent publication No.：
CN105902446A it) discloses a kind of with moisturizing, anti-anaphylaxis, repair and safe mild anti-anaphylaxis reason skin frost, above-mentioned patent
It is not to fight allergic skin diseases using probiotics, application of the probiotics on cosmetics at present is less, probiotics tool
Unsoundness health care is rented, and the substantially reduced allergic symptom of energy has anti-allergic effects, and there are no application probiotics is anti-on the market at present
The cosmetics of allergy occur, and therefore, research and development are a to utilize probiotics fermention, improves treatment allergic symptom, repairs damaged skin, day
The problem of so safety, the cosmetics having no toxic side effect are current urgent need to resolve.
Invention content
To solve the above-mentioned problems, it the present invention provides a kind of probiotics antiallergy repair cream, is sent out by using probiotics
Ferment has effects that the Chinese medicine of antibacterial anti-inflammatory antiallergy, the effect of can not only improving Chinese medicine, moreover it is possible to provide abundant probiotics and stablize
Skin microbial balances, and enhances cutaneous immunisation ability, to reach antiallergy repair.
The present invention can be achieved through the following technical solutions：
A kind of probiotics antiallergy repair cream, is made of following parts by weight：4-5 parts of stearic acid, 3-5 parts of octadecyl alcolol, palm
5-8 parts of isopropyl propionate, 2-3 parts of lanolin, 2-4 parts of saualane, 0.1-0.15 parts of methyl hydroxybenzoate, propylben 0.03-
0.05 part, 3-5 parts of white oil, 0.5-1 parts of olive oil, 5-10 parts of glycerine, 0.3-0.5 parts of triethanolamine, 1-2 parts of Chinese medicine fermented liquid,
0.3-0.5 parts of essence, distilled water to 100.
Preferably, a kind of probiotics antiallergy repair cream is made of following parts by weight：4.2-4.8 parts of stearic acid, ten
Eight 3.5-4.5 parts of alcohol, 6-7 parts of isopropyl palmitate, 2.2-2.8 parts of lanolin, 2.5-3.5 parts of saualane, methyl hydroxybenzoate
0.11-0.14 parts, 0.035-0.045 parts of propylben, 3.5-4.5 parts of white oil, 0.6-0.9 parts of olive oil, 6-9 parts of glycerine,
0.35-0.45 parts of triethanolamine, 1.2-1.8 parts of Chinese medicine fermented liquid, 0.35-0.45 parts of essence, distilled water to 100.
Preferably, a kind of probiotics antiallergy repair cream is made of following parts by weight：4.5 parts of stearic acid, octadecyl alcolol 4
Part, 6.5 parts of isopropyl palmitate, 2.5 parts of lanolin, 3 parts of saualane, 0.12 part of methyl hydroxybenzoate, 0.04 part of propylben,
4 parts of white oil, 0.8 part of olive oil, 7 parts of glycerine, 0.4 part of triethanolamine, 1.5 parts of Chinese medicine fermented liquid, 0.4 part of essence, distilled water are extremely
100。
Preferably, the preparation method of the Chinese medicine fermented liquid is：
(1) preparation of seed liquor：Bacillus acidi lactici is subjected to inclined-plane culture for 24 hours, then picking lactic acid bacillus mycopremna is inoculated in
In aseptic seed culture medium, at 37 DEG C shaken cultivation for 24 hours, rotating speed 120r/min；
(2) herb fermenting culture medium：Take glucose 15g, ammonium sulfate 6g, potassium dihydrogen phosphate 0.5g, peptone 0.5g, Chinese medicine
Extracting solution 1L adjusts medium pH to 6, is placed in high pressure sterilization 20min at 121 DEG C；
(3) fermented and cultured：When Chinese-medicinal culture medium is cooled to 43 DEG C, during Bacillus acidi lactici is inoculated in by 10% inoculum concentration
In medicine fermentation medium, at 37 DEG C, rotating speed is shaken cultivation 12h under conditions of 120r/min, is then centrifuged through 3000r/min
15min, it is Chinese medicine fermented liquid to take supernatant.
Preferably, the Chinese medicine extract of the step (2) consists of the following compositions：The sophora bud, the fruit of summer cypress, honeysuckle, dent
The preparation method of amaranth, wild chrysanthemum, Radix Astragali, Radix Glycyrrhizae, Radix Angelicae Sinensis, ginkgo, the flower bud of lily magnolia, folium artemisiae argyi, kuh-seng, the Chinese medicine extract is：It will be each
Chinese medicine mixing is added 8 times of amount distilled water and decocts 1h, with 6 layers of filtered through gauze, the dregs of a decoction is taken to decoct repeatedly 2 times, 5 times of amounts of the 2nd addition
Distilled water decocts 50min, and 5 times of amount distilled water of the 3rd addition decoct 50min, and filtering merges 2 filtrates, after rotary evaporation concentrates
It mixes with the 1st filtrate and concentrates again, until a concentration of 1g/ml of Chinese medicine extract.
Preferably, the Bacillus acidi lactici is in lactobacillus acidophilus, lactobacillus plantarum, Lactobacillus rhamnosus and Lactobacillus casei
One or more.
Preferably, the content of active probiotic is 1 × 10 in Chinese medicine fermented liquid made from the step (3)7~1 ×
108CFU/g。
A kind of preparation method of probiotics antiallergy repair cream, includes the following steps：
(1) stearic acid, octadecyl alcolol, isopropyl palmitate, lanolin, saualane, white oil, olive oil, methyl hydroxybenzoate are taken
It is mixed with propylben, is heated to 90 DEG C, stirring and dissolving；
(2) glycerine, triethanolamine and distilled water is taken to be heated to 90 DEG C, stirring and dissolving, heat preservation 20min sterilizes；
(3) oil phase is poured into water phase while stirring, is 0.08-0.1MPa in vacuum degree, rotating speed is 10000r/min's
The emulsified 15-20min of condition；
(4) Chinese medicine fermented liquid is added when system to be emulsified is cooled to 50 DEG C, stirs evenly, when being cooled to 45 DEG C, is added fragrant
Essence stirs evenly to get the probiotics antiallergy repair cream of the present invention.
Each main composition mechanism of action of the present invention is as follows：
Flavone compound rutin in the sophora bud has antibacterial and anti-inflammation functions, moreover it is possible to prevent angiorrhoxis, have to ultraviolet light
Stronger absorption and good antioxidation, have the function of skin care jade-like stone face；The fruit of summer cypress being capable of anti-dermatophyte, moreover it is possible to because quick
Skin itching symptom caused by sense；Honeysuckle also known as honeysuckle flowers with resisting pathogenic microbes, enhance the immune function of skin
Effect can inhibit growth, the breeding of Propionibacterium, improve the skin diseases such as acne, small pox, acne；Purslane is cold in nature, sour,
In addition to significant antibiosis and antiviral functions, having to abnormal dermatoses, contact dermatitis etc. improves therapeutic effect；Mother chrysanthemum
Flower can eliminate scytitis, have improvement and therapeutic effect to allergic skin；Contained polysaccharide isoreactivity ingredient can in Radix Astragali
Increase skin collagen content, improve allergic skin skinfold because of caused by water shortage, skin is made to restore skin elasticity；
Glycyrrhizin in Radix Glycyrrhizae can eliminate scytitis, enhance skin anti-virus ability and immunity, while filling for skin
The moisture of foot；Radix Angelicae Sinensis blood circulation promoting and enriching makes blood vessel restore through-flow without hindrance, to nourishes rough skin；Ginkgo can with Radix Glycyrrhizae use in conjunction
Alleviate skin itching symptom, there are anti-allergic effects；Volatile oil in the flower bud of lily magnolia can fight cutaneous anaphylaxis；Folium Artemisiae Argyi extract
There is significant inhibiting effect to bacterial cutaneous pathogenic bacteria, and the pruritis of allergic skin can be improved；Hardship in kuh-seng
Joining alkali not only has anti-allergic effects, moreover it is possible to repair skin, promote skin epithelial cell growth, restore skin elasticity.
The present invention has following advantageous effect：
(1) present invention prepares medicine adornment repair cream using various Chinese medicines as active ingredient, is added to antibacterial anti-inflammatory, anti-mistake
The effects that quick it is important, and by the various active ingredient complementation mutual assistances in Chinese medicine, enhance cutaneous immunisation power, prevent pathogenic bacteria from existing
It is colonized, grows and breeds on skin, and the symptoms such as the general red, itch of allergic skin, shouting pain can be effectively relieved；
(2) Chinese medicine extract is prepared by the Chinese medicine fermented liquid that the present invention adds by lactobacillus fermentation, profit
With lactobacillus fermentation Chinese medicine extract, the effect of enhancing Chinese medicine, acts on, and reduces side effect, and by the active ingredient in Chinese medicine point
Solution becomes small molecule so that active ingredient is easy to skin absorption, can play its drug effect rapidly；
(3) Bacillus acidi lactici is rich in probiotics antiallergy repair cream prepared by the present invention, and there is Bacillus acidi lactici health to promote
Into effect, after skin absorbs, cell balance can be restored by immunoregulation effect, solve sensitive reason from the root cause, to
Realize the preventive and therapeutic effect of anaphylactia；
(4) condition susceptible that the present invention occurs for responsive type skin, the anti-mistake of probiotics prepared using Chinese medicine fermented liquid
Quick repair cream, moreover it is possible to increase skin collagen content, promote the growth of Skin Cell, improve skin moisturizing ability, improve quick
Feel the problem of the tight drying of skin, restore elasticity of skin, to help to repair sensitive skin, improves resisting skin allergy, anti-infective
Ability and skin itself immunocompetence.
Specific implementation mode
In order to make the technical means, the creative features, the aims and the efficiencies achieved by the present invention be easy to understand, tie below
Specific embodiment is closed, the present invention is further explained.
A kind of probiotics antiallergy repair cream embodiment 1-5 formulas of the present invention are as shown in table 1：
Table 1
The preparation method of above-mentioned Chinese medicine fermented liquid is：
(1) preparation of seed liquor：Bacillus acidi lactici is subjected to inclined-plane culture for 24 hours, then picking lactic acid bacillus mycopremna is inoculated in
In aseptic seed culture medium, at 37 DEG C shaken cultivation for 24 hours, rotating speed 120r/min；
(2) herb fermenting culture medium：Take glucose 15g, ammonium sulfate 6g, potassium dihydrogen phosphate 0.5g, peptone 0.5g, Chinese medicine
Extracting solution 1L adjusts medium pH to 6, is placed in high pressure sterilization 20min at 121 DEG C；
(3) fermented and cultured：When Chinese-medicinal culture medium is cooled to 43 DEG C, during Bacillus acidi lactici is inoculated in by 10% inoculum concentration
In medicine fermentation medium, at 37 DEG C, rotating speed is shaken cultivation 12h under conditions of 120r/min, is then centrifuged through 3000r/min
15min, it is Chinese medicine fermented liquid to take supernatant.
The Chinese medicine extract of above-mentioned steps (2) consists of the following compositions：The sophora bud, the fruit of summer cypress, honeysuckle, purslane, mother chrysanthemum
The preparation method of flower, Radix Astragali, Radix Glycyrrhizae, Radix Angelicae Sinensis, ginkgo, the flower bud of lily magnolia, folium artemisiae argyi, kuh-seng, the Chinese medicine extract is：Each Chinese medicine is mixed
8 times of amount distilled water are added and decoct 1h, with 6 layers of filtered through gauze, the dregs of a decoction are taken to decoct repeatedly 2 times, 5 times of amount distillation decoctings of the 2nd addition
Boil 50min, 5 times of amount distilled water be added and decoct 50min for the 3rd time, filtering merges 2 filtrates, after rotary evaporation concentration with the 1st time
Filtrate mixing concentrates again, until a concentration of 1g/ml of Chinese medicine extract.
Above-mentioned Bacillus acidi lactici is one kind in lactobacillus acidophilus, lactobacillus plantarum, Lactobacillus rhamnosus and Lactobacillus casei
Or it is several.
The content of active probiotic is 1 × 10 in Chinese medicine fermented liquid made from above-mentioned steps (3)7~1 × 108CFU/g。
A kind of preparation method of above-mentioned probiotics antiallergy repair cream, includes the following steps：
(1) stearic acid, octadecyl alcolol, isopropyl palmitate, lanolin, saualane, white oil, olive oil, methyl hydroxybenzoate are taken
It is mixed with propylben, is heated to 90 DEG C, stirring and dissolving；
(2) glycerine, triethanolamine and distilled water is taken to be heated to 90 DEG C, stirring and dissolving, heat preservation 20min sterilizes；
(3) oil phase is poured into water phase while stirring, is 0.08-0.1MPa in vacuum degree, rotating speed is 10000r/min's
The emulsified 15-20min of condition；
(4) Chinese medicine fermented liquid is added when system to be emulsified is cooled to 50 DEG C, stirs evenly, when being cooled to 45 DEG C, is added fragrant
Essence stirs evenly to get the probiotics antiallergy repair cream of the present invention.
Comparative example 1
Difference lies in without addition Chinese medicine fermented liquid in composition of raw materials with embodiment 1.
Comparative example 2
Difference lies in add the Chinese medicine extract without probiotics fermention with embodiment 1 in composition of raw materials.
Comparative example 3
Difference lies in as a control group using basic repair cream with embodiment 1.
Efficacy validation
Test example 1
Probiotics antiallergy repair cream prepared by the present invention is taken to carry out the related experiment of skin barrier function maintenance and reparation,
Respectively hyaluronidase Inhibition test and erythrocyte hemolysis experiment, the results are shown in Table 2：
2 each group hyaluronic acid enzyme inhibition rate of table and irritation measurement result
| Group | Hyaluronic acid enzyme inhibition rate (%) | Hemolysis rate (%) |
| Embodiment 1 | 88 | 2.8 |
| Embodiment 2 | 90 | 3.0 |
| Embodiment 3 | 92 | 3.2 |
| Embodiment 4 | 91 | 3.1 |
| Embodiment 5 | 89 | 2.9 |
| Comparative example 1 | 48 | 5.5 |
| Comparative example 2 | 66 | 5.2 |
| Comparative example 3 | 24 | 5.8 |
As shown in Table 2, the hyaluronic acid enzyme inhibition rate of embodiment 1-5 is higher, and up to 92%, with comparative example 1, comparison
Example 2 is compared with comparative example 3, all has larger difference, illustrates that probiotics antiallergy repair cream prepared by the present invention has relatively by force
Antiallergic activity；From the point of view of hemolysis rate, the hemolysis rate of embodiment 1-5 and comparative example 1-3 is below 10%, and hemolysis rate is lower,
Irritation is lower, and safety is higher, and embodiment 1-5, compared with comparative example 1-3, hemolysis rate is substantially reduced, and illustrates system of the present invention
Standby probiotics antiallergy repair cream irritation is relatively low, safe without toxic side effect.
2 human body patch of test example is tested
Filter paper is placed in spot examination device, the SDS of appropriate 10% concentration is added dropwise, stick with subject's inner forearm, it is tested
5h removes patch, change of skin is observed after half an hour, removes patch, repair cream prepared by Example 1-5 and comparative example 1-5
It is added dropwise in the filter paper in spot examination device, control wells are blank control group, and light pressure is allowed to equably be pasted in subject's forearm
Side removes patch, change of skin is observed after half an hour after continuing 15h, then, the variation of recipient site, knot is observed after 27h
Fruit is as shown in table 3：
3 each group subjects skin's reaction result of table
As can be seen from Table 3, when tested skin is by same allergic lesions, the repair cream that is prepared using embodiment 1-5
Afterwards, damaged skin cell membrane can be obviously repaired, skin elasticity is restored, and the repair ability of comparative example 1-3 groups is not so good as embodiment 1-5
Group illustrates that repair cream prepared by the present invention has good reparation skin injury ability, and has significant antiphlogistic effects.
In conclusion not only irritation is low for the probiotics antiallergy repair cream for preparing of the present invention, it is safe, moreover it is possible to slow down
Stimulus repairs damaged cell film, help restores skin elasticity, rich in gloss to the damage caused by skin.
Several embodiments of the invention above described embodiment only expresses, the description thereof is more specific and detailed, but simultaneously
Cannot the limitation to the scope of the claims of the present invention therefore be interpreted as.It should be pointed out that for those of ordinary skill in the art
For, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to the guarantor of the present invention
Protect range.
Claims (8)
1. a kind of probiotics antiallergy repair cream, which is characterized in that be composed of the following raw materials by weight：4-5 parts of stearic acid, 18
3-5 parts of alcohol, 5-8 parts of isopropyl palmitate, 2-3 parts of lanolin, 2-4 parts of saualane, 0.1-0.15 parts of methyl hydroxybenzoate, nipalgin
0.03-0.05 parts of propyl ester, 3-5 parts of white oil, 0.5-1 parts of olive oil, 5-10 parts of glycerine, 0.3-0.5 parts of triethanolamine, herb fermenting
1-2 parts of liquid, 0.3-0.5 parts of essence, distilled water to 100.
2. a kind of probiotics antiallergy repair cream according to claim 1, which is characterized in that by following raw material group
At：4.2-4.8 parts of stearic acid, 3.5-4.5 parts of octadecyl alcolol, 6-7 parts of isopropyl palmitate, 2.2-2.8 parts of lanolin, saualane
2.5-3.5 parts, 0.11-0.14 parts of methyl hydroxybenzoate, 0.035-0.045 parts of propylben, 3.5-4.5 parts of white oil, olive oil
0.6-0.9 parts, 6-9 parts of glycerine, 0.35-0.45 parts of triethanolamine, 1.2-1.8 parts of Chinese medicine fermented liquid, 0.35-0.45 parts of essence,
Distilled water is to 100.
3. a kind of probiotics antiallergy repair cream according to claim 1 or 2, which is characterized in that by following parts by weight original
Material composition：4.5 parts of stearic acid, 4 parts of octadecyl alcolol, 6.5 parts of isopropyl palmitate, 2.5 parts of lanolin, 3 parts of saualane, Metagin
0.12 part of ester, 0.04 part of propylben, 4 parts of white oil, 0.8 part of olive oil, 7 parts of glycerine, 0.4 part of triethanolamine, herb fermenting
1.5 parts of liquid, 0.4 part of essence, distilled water to 100.
4. according to a kind of probiotics antiallergy repair cream of claim 1-3 any one of them, which is characterized in that the Chinese medicine hair
The preparation method of zymotic fluid is：
(1) preparation of seed liquor：Bacillus acidi lactici is subjected to inclined-plane culture for 24 hours, then picking lactic acid bacillus mycopremna is inoculated in sterile
In seed culture medium, at 37 DEG C shaken cultivation for 24 hours, rotating speed 120r/min；
(2) herb fermenting culture medium：Take glucose 15g, ammonium sulfate 6g, potassium dihydrogen phosphate 0.5g, peptone 0.5g, traditional Chinese medicine extraction
Liquid 1L adjusts medium pH to 6, is placed in high pressure sterilization 20min at 121 DEG C；
(3) fermented and cultured：When Chinese-medicinal culture medium is cooled to 43 DEG C, Bacillus acidi lactici is inoculated in Chinese medicine hair by 10% inoculum concentration
In ferment culture medium, at 37 DEG C, rotating speed is shaken cultivation 12h under conditions of 120r/min, then centrifuges 15min through 3000r/min,
It is Chinese medicine fermented liquid to take supernatant.
5. a kind of probiotics antiallergy repair cream according to claim 4, which is characterized in that the Chinese medicine of the step (2)
Extracting solution consists of the following compositions：It is the sophora bud, the fruit of summer cypress, honeysuckle, purslane, wild chrysanthemum, Radix Astragali, Radix Glycyrrhizae, Radix Angelicae Sinensis, ginkgo, pungent
The preparation method of the name for ancient tribes in the east, folium artemisiae argyi, kuh-seng, the Chinese medicine extract is：Each Chinese medicine is mixed, 8 times of amount distilled water decoction 1h are added, with 6
Layer filtered through gauze takes the dregs of a decoction to decoct repeatedly 2 times, and 5 times of amount distilled water of the 2nd addition decoct 50min, and 5 times of amounts of the 3rd addition are distilled
Water decocts 50min, and filtering merges 2 filtrates, mixes with the 1st filtrate after rotary evaporation concentration and concentrate again, until Chinese medicine extract
A concentration of 1g/ml.
6. a kind of probiotics antiallergy repair cream according to claim 4, which is characterized in that the Bacillus acidi lactici is acidophilus
One or more of lactobacillus, lactobacillus plantarum, Lactobacillus rhamnosus and Lactobacillus casei.
7. a kind of probiotics antiallergy repair cream according to claim 4, which is characterized in that the step (3) is obtained
The content of active probiotic is 1 × 10 in Chinese medicine fermented liquid7~1 × 108CFU/g。
8. a kind of preparation method of probiotics antiallergy repair cream, which is characterized in that include the following steps：
(1) stearic acid, octadecyl alcolol, isopropyl palmitate, lanolin, saualane, white oil, olive oil, methyl hydroxybenzoate and Buddhist nun are taken
The golden propyl ester mixing of pool, is heated to 90 DEG C, stirring and dissolving；
(2) glycerine, triethanolamine and distilled water is taken to be heated to 90 DEG C, stirring and dissolving, heat preservation 20min sterilizes；
(3) oil phase is poured into water phase while stirring, is 0.08-0.1MPa in vacuum degree, rotating speed is the condition of 10000r/min
Emulsified 15-20min；
(4) Chinese medicine fermented liquid is added when system to be emulsified is cooled to 50 DEG C, stirs evenly, when being cooled to 45 DEG C, essence is added, stirs
It mixes uniformly to get the probiotics antiallergy repair cream of the present invention.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810647930.4A CN108451889A (en) | 2018-06-21 | 2018-06-21 | A kind of probiotics antiallergy repair cream |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810647930.4A CN108451889A (en) | 2018-06-21 | 2018-06-21 | A kind of probiotics antiallergy repair cream |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108451889A true CN108451889A (en) | 2018-08-28 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201810647930.4A Withdrawn CN108451889A (en) | 2018-06-21 | 2018-06-21 | A kind of probiotics antiallergy repair cream |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111358847A (en) * | 2020-03-12 | 2020-07-03 | 北京安洁优科技有限公司 | Antibacterial and antiallergic micron traditional Chinese medicine lactein (AABNDL) and preparation method and application thereof |
| CN111904923A (en) * | 2020-08-11 | 2020-11-10 | 江苏华能药业有限公司 | Probiotic and metazoan composition set |
| CN113057933A (en) * | 2021-04-04 | 2021-07-02 | 山西医科大学 | Emollient for maintaining and remodeling skin micro-ecology and preparation method thereof |
| CN115054550A (en) * | 2022-07-05 | 2022-09-16 | 中南大学 | Composite face cream, preparation method thereof and application thereof in skin care |
-
2018
- 2018-06-21 CN CN201810647930.4A patent/CN108451889A/en not_active Withdrawn
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111358847A (en) * | 2020-03-12 | 2020-07-03 | 北京安洁优科技有限公司 | Antibacterial and antiallergic micron traditional Chinese medicine lactein (AABNDL) and preparation method and application thereof |
| CN111904923A (en) * | 2020-08-11 | 2020-11-10 | 江苏华能药业有限公司 | Probiotic and metazoan composition set |
| CN113057933A (en) * | 2021-04-04 | 2021-07-02 | 山西医科大学 | Emollient for maintaining and remodeling skin micro-ecology and preparation method thereof |
| CN115054550A (en) * | 2022-07-05 | 2022-09-16 | 中南大学 | Composite face cream, preparation method thereof and application thereof in skin care |
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Application publication date: 20180828 |