CN106963674A - A kind of Whitening, spot composition and its application - Google Patents
A kind of Whitening, spot composition and its application Download PDFInfo
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- CN106963674A CN106963674A CN201710148746.0A CN201710148746A CN106963674A CN 106963674 A CN106963674 A CN 106963674A CN 201710148746 A CN201710148746 A CN 201710148746A CN 106963674 A CN106963674 A CN 106963674A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
Abstract
The invention discloses a kind of Whitening, spot plant composition and its application, composition is made up of 0.5 2.8 parts of strand Ka Kele leaf extracts, 0.2 1.4 parts of kudzu root extract, 0.1 1.8 parts of walnut peel extract, several composition compoundings, by removing free radical, suppressing the approach such as tyrosinase, reduction pigmentation, efficient whitening spot-removing effect is reached.Composition is added in face cream, safe, stability is good, effect significantly, is used for a long time, and skin can be made to moisten pale, high resilience.
Description
Technical field
The present invention relates to cosmetic field, and in particular to a kind of Whitening, spot composition and its application.
Background technology
With the improvement of living standards, people are increasingly strong to whitening skin, glossy pursuit.Using skin-lightening cosmetic with
Realize skin Lightening, the fair and clear common aspiration as many women.Free radical attack cells destroying cells film, causes cell death
Changed with cell membrane, so that cell can not absorb nutrition from outside, also can not drain the product of endocellular metabolism, it is long
Phase accumulates to form melanin, causes the formation of the various spots such as skin splash, butterfly macules.Whitening, nti-freckle class skin care item are always
The emphasis of research, product is also constantly weeded out the old and bring forth the new.The whitening and skin-protecting of a new generation focuses on full effect whitening, the skin care reason of natural safety
Thought is also rooted in the hearts of the people.Compounding, which is carried out, by a variety of whitening active materials produces synergy, multi-angle, Mutiple Targets and regulation black
Element generation, payes attention to carrying out full protection and nutrition reparation to ultraviolet, on the basis of whitening, addition NMF, antioxidant
The effects such as composition, prepare with whitening, moisturizing, light spot, it is anti-ageing wait for a long time multiple-effect unification skin care item, the need of a variety of skin can be met
Ask.
Chinese patent application CN104116688A discloses kojic acid freckle removing and whitening frost, including kojic acid, fibroin, ethanol, poly- third
Olefin(e) acid, to hydroxyl Lay tetracarboxylic acid formicester, propolis, spiny dogfish shallow lake, kaolin etc..Kojic acid in the composition of the invention can be black by blocking
Pigment generates intermediate to reach whitening effect, but is used for a long time, and can produce CDCC, increase gonad cell chromosome
The probability of distortion.
The various heavy compound such as mercury compound added in skin-lightening cosmetic of the prior art, due to forming complexing
Thing is very competent, and the formation of epidermis enzyme can be destroyed from mechanism, so as to suppress the formation of melanin, plays skin whitening effect,
Such product, is used for a long time easily carcinogenic；Part lead-containing compounds, vision whitening function is played by covering；Portioned product is also
Skin surface is bleached using strong oxidizer, the mode such as excessive exfoliating carries out whitening, is chronic to skin if things go on like this
Disfeature！So a safely and effectively Whitening, spot product of research and development, is one of emphasis of cosmetics research and development.
The content of the invention
In view of the shortcomings of the prior art, it is an object of the invention to provide a kind of safely and effectively Whitening, spot plant society
Thing, and added in face cream, impart the significant Whitening, spot effect of face cream.
To achieve the above object, the present invention provides following technical scheme：
A kind of Whitening, spot plant composition is consisted of the following composition：Strand Ka Kele leaf extracts, kudzu root extract, core
Peach peel extract.Wherein, the parts by weight of each composition are in the composition：0.5-2.8 parts of strand Ka Kele leaf extracts, Pueraria lobota
0.2-1.4 parts of root extract, 0.1-1.8 parts of walnut peel extract.
The preparation method of the strand Ka Kele leaf extracts is：Strand Ka Keleye is taken, thick end, plus 4-6 times is ground into
Measure deionized water and decoct 30-900min, repeat 2-4 times, collecting decoction, filtering, normal pressure is concentrated into pasty state；Above-mentioned pastel is taken,
Plus 4 times of amount 75-90% ethanol stir, sodium hydroxide solution is added dropwise and adjusts pH to 8, it is closed to stand overnight；Feed liquid is depressurized
Suction filtration, filtrate recycling ethanol is to without alcohol taste, and 0-4 DEG C refrigerates filtrate normal pressure after 24h and concentrate, and obtains strand Ka Kele leaf extracts.
The preparation method of the kudzu root extract is：The fresh root of kudzu vine is taken, clean dry is ground into coarse grain, coarse grain decocting
Extraction 2-3 times is boiled, each 2-3h of decocting time merges filtrate twice, stands 2-4h, and filtering, filtrate is standby；Filtrate decompression is dense
Contracted to obtain thick medicinal extract, and the fine powder of 65-80 mesh sizes is ground into after thick medicinal extract is spray-dried, and produces the kudzu root extract.
The preparation method of the walnut peel extract is：Take green peel of walnut to clean, be put into juice extractor and squeeze broken；It will squeeze
Rascal juice pour into container, add concentration 75-85% ethanol solution, stir；15-24h is extracted, residue is filtered off, will
Filtrate is concentrated into solid with Rotary Evaporators pressurization；Gained solid is ground into 60-80 mesh fine powders, the green peel of walnut is produced and carries
Take thing.
The present invention also provides application of the Whitening, spot plant composition in cosmetics are prepared, and the cosmetics are face cream.
The face cream is consisted of the following composition：1-6 parts of Whitening, spot plant composition, 2-12 parts of NMF, emulsifying agent
1.2-5 parts, 0.1-0.3 parts of thickener, 0.2-1 parts of preservative, 5-9 parts of emollient, 0.02-0.3 parts of potassium hydroxide, deionized water
Add to 100 parts.
The NMF is at least one of Sodium Hyaluronate, glycerine and sorbierite；The emulsifying agent is glyceryl stearate
Acid esters/PEG-100 stearates, the smooth olive oleate of the smooth palmitate/sorb of cetanol palmitate/sorb, C14-22 alcohol/
At least one of C12-20 alkyl glucosides and olive oil PEG-7；The thickener is xanthans, hydroxyethyl cellulose, carboxylic
At least one of sodium carboxymethylcellulose pyce；The preservative is at least one of Phenoxyethanol, methyl hydroxybenzoate, Nipasol；
The emollient is saualane, cetostearyl alcohol, dimethyl silicone polymer, Butyrospermum parkii fruit fat, hydrogenated jojoba oil, poly- diformazan
At least one of radical siloxane/dimethiconol.
The present invention also provides the preparation method of Whitening, spot face cream, comprises the following steps：By emulsifying agent, emollient input oil
In phase pot, 70-85 DEG C is heated to, waits all components to be incubated after dissolving, A phases is made；By NMF, thickener and deionized water according to
In secondary input emulsification pot, 70-85 DEG C is heated to, insulation 15-30min makes it fully dissolve, and B phases are made；A phase B phases are taken out successively
Enter into homogenizer, homogeneous 5-15min, stir speed (S.S.) is 2000-4000r/min, then insulated and stirred 15-45min, stirring speed
Rate is 30-50r/min；40-45 DEG C is cooled to, potassium hydroxide is added, stirs；Whitening, spot of the present invention is added to plant
Compositions, preservative, stir, and obtain whitening cream.
Following introduction is done to the fractions of the present invention：
Strand Ka Kele is one of common halophytes of seashore, is generally grown in Sha Shanshang, oneself is wide in ethnic drug
It is general to use.Strand Ka Kele has diuresis, and Vitamin C disease promotees digestion, defaecation, eliminating jaundice edema, regulation scrofula and pouring
The multiple efficacies such as bar disorder.Strand Ka Kele grows by the sea, has substantial amounts of aldehydes matter to accumulate in its blade under high salinity stress
It is tired, such as flavonoids, sinapic acid.These aldehydes matters generally have antioxidation activity, can effectively remove DPPH free radicals, super oxygen
Radical anion, hydroxy radical, and its Scavenging ability is better than vitamin C.
The root of kudzu vine is one of Chinese medicine of China's medicine-food two-purpose, and main component is Puerarin, daizeol and isoflavones etc.
Flavone compound.Flavone compound scavenging activated oxygen can not only nourish skin in time, also can further suppress tyrosine
The catalytic activity of enzyme, reduces pigment in skin and generates, prevent pigmentation, reach the purpose of skin whitening.
Green peel of walnut is immature green pericarp outside walnut, rich in various active material, with significant anti-oxidant
Effect.7 kinds of main components with strong anti-oxidative activity are chlorogenic acid, brevifolin carboxylic acid, flower indigo-grape in green peel of walnut
Sugar/galactolipin, tan flower, Quercetin-arabinose, epicatechin or catechin, Quercitrin-3-O-glucoside.
Compared with prior art, the device have the advantages that as follows：(1) the strand Ka Keleye in the present invention is extracted
The excellent effect of scavenging radical of thing；Kudzu root extract further suppresses tyrosinase activity, reduces pigmentation；Green peel of walnut
Extract strengthens the antioxidation of composition, and several component compoundings can reach efficient whitening spot-removing effect；(2) strand is used
Ka Kele blade extracts as active component so that the recovery rate of active component is higher；Green peel of walnut is more in walnut production
Thrown away as discarded object, cause the significant wastage of environmental pollution and resource, but make full use of in the present invention in green peel of walnut
Active ingredient so that the present invention defers to theories such as " environmental protection economize on resources, rationally utilizes resource "；(3) present invention is provided
NMF and emollient have excellent skin-moisturizing, skin effect, and the vigor of skin collagen layer is added while moisturizing water lock,
So that skin is more flexible；(4) face cream of the invention is not stimulated gently, and safe, stability is good；Its simple production process,
Marketing can be carried out.
Brief description of the drawings
Fig. 1：Scavenging activity of the face cream of Whitening, spot plant composition to DPPH.
Fig. 2：Inhibitory action of the face cream of Whitening, spot plant composition to TYR enzyme activity.
Embodiment
The present invention is further elaborated by the following specific embodiment
The following component title occurred in text is INCI (Internation Nomenclaure Cosmetic
Ingredent, i.e. international cosmetic raw material name) institute to defined title：Stearine/PEG-100 stearates, whale
The smooth olive oleate of the smooth palmitate/sorb of ceryl alcohol palmitate/sorb, C14-22 alcohol/C12-20 alkyl glucosides, poly- two
Methylsiloxane/dimethiconol.
The whitening emollient cream formula of the present invention of the embodiment of the present invention 1~5 is shown in Table one
The preparation method of above-described embodiment strand Ka Kele leaf extracts is：Strand Ka Keleye is taken, thick end is ground into, plus
5 times of amount deionized waters decoct 500min, are repeated 3 times, collecting decoction, filter, normal pressure is concentrated into pasty state；Above-mentioned pastel is taken, plus 4
80% ethanol of amount stirs again, and sodium hydroxide solution is added dropwise and adjusts pH to 8, closed to stand overnight；Feed liquid is depressurized into suction filtration, filtered
Liquid reclaims ethanol to without alcohol taste, and 4 DEG C refrigerate filtrate normal pressure after 24h and concentrate, and obtain strand Ka Kele leaf extracts.
The preparation method of kudzu root extract is：The fresh root of kudzu vine is taken, clean dry is ground into coarse grain, and coarse grain is boiled with decocting and carried
Take 2 times, each 3h of decocting time, merge filtrate twice, stand 4h, filtering, filtrate is standby；Filtrate decompression is concentrated to give thick leaching
Cream, is ground into the fine powder of 65 mesh sizes, produces the kudzu root extract after thick medicinal extract is spray-dried.
The preparation method of walnut peel extract is：Take green peel of walnut to clean, be put into juice extractor and squeeze broken；By the green grass or young crops squeezed
Skin juice is poured into container, is added the ethanol solution of concentration 85%, is stirred；20h is extracted, residue is filtered off, filtrate is rotated
Evaporimeter pressurization is concentrated into solid；Gained solid is ground into 60 mesh fine powders, the walnut peel extract is produced.
The method for preparing the Whitening, spot face cream of embodiment 1~5, comprises the following steps：By stearine/PEG-100
Stearate, the smooth olive oleate of the smooth palmitate/sorb of cetanol palmitate/sorb, C14-22 alcohol/C12-20 alkyl Portugal
Glucosides and olive oil PEG-7, saualane, cetostearyl alcohol, dimethyl silicone polymer, Butyrospermum parkii fruit fat, hydrogenated jojoba oil,
In polydimethyl siloxanes/polydimethy siloxanes alcohol input oil phase pots, 80 DEG C are heated to, waits all components to be incubated after dissolving,
A phases are made；By in Sodium Hyaluronate, glycerine and sorbierite, xanthans, hydroxyethyl cellulose, sodium carboxymethylcellulose and go from
Sub- water is put into emulsification pot successively, is heated to 70 DEG C, insulation 30min makes it fully dissolve, and B phases are made；A phase B phases are taken out successively
Enter into homogenizer, homogeneous 10min, stir speed (S.S.) is 3000r/min, then insulated and stirred 30min, stir speed (S.S.) is 40r/
min；45 DEG C are cooled to, potassium hydroxide is added, stirs；Add Whitening, spot plant composition, Phenoxyethanol, oxybenzene first
Ester, Nipasol, stir, and obtain Whitening, spot face cream.
Comparative example 1
Difference with embodiment 1 is not add strand Ka Kele leaf extracts, other preparation conditions and method and embodiment 1
It is identical.
Comparative example 2
Difference with embodiment 1 is not add kudzu root extract, and other preparation conditions and method are same as Example 1.
Comparative example 3
Difference with embodiment 1 is not add walnut peel extract, other preparation conditions and method and the phase of embodiment 1
Together.
Comparative example 4
Difference with embodiment 1 is not add Whitening, spot plant composition, other preparation conditions and method and embodiment 1
It is identical.
Comparative example 5
Difference with embodiment 1 is that Whitening, spot plant composition content is 6.1 parts, other preparation conditions and method and reality
Apply example 1 identical.
Comparative example 6
Difference with embodiment 1 is that Whitening, spot plant composition content is 0.9 part, other preparation conditions and method and reality
Apply example 1 identical.
Whitening, spot plant composition of the present invention removes DPPH capacity experimentals
Method and apparatus
The Whitening, spot plant composition (self-control) of embodiment 1；95% ethanol (Chemical Reagent Co., Ltd., Sinopharm Group)；
DPPH (Tokyo is melted into Co., Ltd., analyzes pure)；AB204-E electronic analytical balances (METTLE TOLEDO)；UV-1600
Ultraviolet specrophotometer (METTLE TOLEDO).
Black purple is presented in DPPH in absolute ethyl alcohol and ethanol-water system, there is maximum suction under 517nm and 525nm respectively
Receive.Free radical scavenger can make purple gradually retreat, and determine DPPH content according to the change of absorbance and react freely
Scavenging activity of the base scavenger to DPPH.
Precision weighs DPPH3.00mg, is dissolved with 95% ethanol and is settled to 100ml, and DPPH solubility is 20mg/L, is taken
4mlDPPH standard liquids, are positioned in test tube, add 1ml Whitening, spot plant composition solution, place after 30min,
517nm determines absorbance A.DPPH clearance rates are determined according to following equation；
DPPH clearance rate=[1- (Ai-Aj)/Ac] × 100%
Ai：The absorbance of extract solution+4mlDPPH solution
Aj：The absorbance of extract solution+4ml95% ethanol
Ac：The absorbance of 1ml95% ethanol+4mlDPPH solution
DPPH Scavenging activities are represented with clearance rate, clearance rate is higher to represent that Scavenging activity is stronger, by Whitening, spot plant
Composition is diluted to 5%, 10%, 15%, 20%, 25% respectively with 95% ethanol, detects that each concentration removes DPPH energy
Power.As a result Fig. 1 is seen.
As can be seen from Figure 1 Whitening, spot plant composition has Scavenging activity to DPPH, and as concentration increases clear
Except degree gradually increases, removing degree tends towards stability after concentration reaches 15%, and clearance rate reaches 84%.
Whitening, spot plant composition of the present invention suppresses TYR enzyme experiment
Method and apparatus
The Whitening, spot plant composition of embodiment 1；Ph=6.8 phosphate buffer solutions (PBS solution), sodium hydroxide (traditional Chinese medicines
Chemical reagent Co., Ltd of group)；TYR enzyme, Tyrosinase EC 1.14.18.19 (signa)；L-DOPA
(AcrosOrganics)；AB204-E electronic analytical balances (METTLE TOLEDO)；UV-1600 ultraviolet specrophotometers
(METTLE TOLEDO)。
During TYR changes into melanin, the catalytic action of TYR enzyme occurs mainly in TYR enzyme and is converted into
DOPA and DOPA change into the process of DOPA quinone, and DOPA quinone is a kind of coloring matter, has absorption at 475nm, using light splitting
Photometer measurement content.L-DOPA is substrate, determines the TYR enzyme inhibitory activity of Whitening, spot plant composition of the present invention.
The testing sample composition of table two
Whitening, spot plant composition extract solution of the present invention, 0.15% DOPA solution are drawn according to accurate shown in table two,
The TYR enzyme solution that 300 μ/mL is uniformly added after being incubated 10 minutes in 30 DEG C of water-baths is sufficiently mixed, continues to cultivate very
Clock, determines its light absorption value in 475nm immediately.
The calculation formula of TYR enzyme inhibiting rate (I) is as follows：
I=[(A-B)-(C-D)]/[A-B] × 100%
A:Not plus the absorbance A (A) surveyed of the enzyme-added mixed liquor of Whitening, spot plant composition；
B:Not plus Whitening, spot plant composition and not plus the absorbance A (B) surveyed of enzyme-added mixed liquor；
C：Plus Whitening, spot plant composition and enzyme-added absorbance A (C) mixed liquor, being surveyed；
D:Plus the absorbance A (D) that the not enzyme-added mixed liquor of Whitening, spot plant composition is surveyed.
Whitening, spot plant composition sample is diluted to 5%, 10%, 15%, 20% with PBS respectively, 25% detection is each
Individual concentration suppresses TYR enzyme activity.As a result Fig. 2 is seen.
Whitening, spot plant composition concentration is when 5% to 25% as seen from Figure 2, the suppression of Whitening, spot plant composition
TYR enzyme activity processed increases with the growth of metering, when suppression TYR enzyme activity solubility reaches 15%, TYR enzyme
Inhibiting rate can reach 83%.
Whitening effect is verified
Detection results on probation are carried out to product prepared by embodiment 1-5 and comparative example 1-7.Test object：Each experimental group is equal
For 20 women (25-50 Sui), comparative example 7 is the commercially available whitening emollient cream of whitening spot-removing excellent；Test zone：Face；
Use：Twice daily, persistently using 4 weeks；Test event：Whitening spot-removing, skin water are tender, skin elasticity.Result on trial see the table below
Three.
By the visible whitening spot-removing of embodiment 1~5 of table three, water is tender and skin elasticity improves obvious number and is significantly more than contrast
Example 1~6 and control group, illustrate that the made whitening emollient cream of Whitening, spot plant composition of the present invention is significantly improved whitening and dispelled
Tender and skin elasticity the effect of spot, skin water；The whitening spot-removing of comparative example 4 is obviously improved 6 people, and skin water is tender to be obviously improved 6 people,
Skin elasticity is obviously improved 5 people, hence it is evident that less than other embodiment and comparative example, illustrates that Whitening, spot plant composition of the present invention is
The principle active component of whitening emollient cream；Comparative example 1 does not add strand Ka Kele leaf extracts, and its whitening spot-removing, water is tender and skin
It is respectively that 10 people, 10 people, 10 people are tender far below the whitening spot-removing of embodiment 1, water and skin elasticity that skin elasticity, which improves obvious number,
Improve obvious number；Comparative example 2 and comparative example 3 are respectively to be not added with kudzu root extract and walnut peel extract, its whitening
Nti-freckle, water are tender and skin elasticity improves obvious number and is significantly lower than embodiment 1, and comparative example 1~3 can with the contrast of embodiment 1
See in the made whitening emollient cream of Whitening, spot composition, strand Ka Kele leaf extracts, kudzu root extract and green peel of walnut
Extract Synergistic.
Above example only illustrates embodiment of the present invention, does not have any formal limitation to the present invention；Appoint
What is engaged in professional and technical personnel, all has the ability to make some changes using the technology contents disclosed or modifies, as equivalent
The equivalent embodiment of change, according to the technology of the present invention essence, simply modification, equivalent variations and modification is carried out to the present invention, is belonged to
In the range of technical solution of the present invention.
Claims (9)
1. a kind of Whitening, spot plant composition, it is characterised in that the composition is consisted of the following composition：Strand Ka Keleye
Extract, kudzu root extract, walnut peel extract, wherein, the parts by weight of each composition are in the composition：
0.5-2.8 parts of strand Ka Kele leaf extracts
0.2-1.4 parts of kudzu root extract
0.3-1.8 parts of walnut peel extract.
2. a kind of Whitening, spot plant composition according to claim 1, it is characterised in that the strand Ka Keleye is carried
The preparation method for taking thing is：Strand Ka Keleye is taken, thick end is ground into, plus 4-6 times is measured deionized water and decocts 30-900min, weight
Multiple 2-4 times, collecting decoction, filtering, normal pressure is concentrated into pasty state；Above-mentioned pastel, plus 4 times of amount 75-90% ethanol is taken to stir,
Sodium hydroxide solution is added dropwise and adjusts pH to 8, it is closed to stand overnight；Feed liquid is depressurized into suction filtration, filtrate recycling ethanol is to without alcohol taste, 0-
Filtrate normal pressure is concentrated after 4 DEG C of refrigeration 24h, obtains strand Ka Kele leaf extracts.
3. a kind of Whitening, spot plant composition according to claim 1, it is characterised in that the system of the kudzu root extract
Preparation Method is：Take the fresh root of kudzu vine, clean dry is ground into coarse grain, coarse grain water boiling and extraction 2-3 times, each 2- of decocting time
3h, merges filtrate twice, stands 2-4h, and filtering, filtrate is standby；Filtrate decompression is concentrated to give thick medicinal extract, thick medicinal extract is sprayed
Mist crushed after being dried produces the kudzu root extract into the fine powder of 65-80 mesh sizes.
4. a kind of Whitening, spot plant composition according to claim 1, it is characterised in that the walnut peel extract
Preparation method be：Take green peel of walnut to clean, be put into juice extractor and squeeze broken；The rascal juice squeezed is poured into container, added dense
75-85% ethanol solution is spent, is stirred；15-24h is extracted, residue is filtered off, filtrate is concentrated into Rotary Evaporators pressurization
Solid；Gained solid is ground into 60-80 mesh fine powders, the walnut peel extract is produced.
5. application of the Whitening, spot plant composition according to claim any one of 1-4 in cosmetics are prepared.
6. application according to claim 5, it is characterised in that the cosmetics are face cream.
7. a kind of Whitening, spot face cream, it is characterised in that the face cream is consisted of the following composition：
1-6 parts of the Whitening, spot plant composition as described in claim any one of 1-4
2-12 parts of NMF
1.2-5 parts of emulsifying agent
0.1-0.3 parts of thickener
0.2-1 parts of preservative
5-9 parts of emollient
0.02-0.3 parts of potassium hydroxide
Deionized water adds to 100 parts.
8. a kind of Whitening, spot face cream according to claim 7, it is characterised in that the NMF be Sodium Hyaluronate,
At least one of glycerine and sorbierite；The emulsifying agent is stearine/PEG-100 stearates, cetanol palm
In the smooth olive oleate of the smooth palmitate/sorb of acid esters/sorb, C14-22 alcohol/C12-20 alkyl glucosides and olive oil PEG-7
At least one；The thickener is at least one of xanthans, hydroxyethyl cellulose, sodium carboxymethylcellulose；It is described anti-
Rotten agent is at least one of Phenoxyethanol, methyl hydroxybenzoate, Nipasol；The emollient is saualane, cetostearyl alcohol, gathered
In dimethyl siloxane, Butyrospermum parkii fruit fat, hydrogenated jojoba oil, polydimethyl siloxanes/polydimethy siloxanes alcohol extremely
Few one kind.
9. a kind of method for preparing Whitening, spot face cream as claimed in claim 7, preparation method described in its feature includes following
Step：By in emulsifying agent, emollient input oil phase pot, 70-85 DEG C is heated to, waits all components to be incubated after dissolving, A phases is made；
NMF, thickener and deionized water are put into emulsification pot successively, 70-85 DEG C is heated to, insulation 15-30min makes its abundant
Dissolving, is made B phases；A phase B phases are pumped into homogenizer successively, homogeneous 5-15min, stir speed (S.S.) is 2000-4000r/min,
Then insulated and stirred 15-45min, stir speed (S.S.) is 30-50r/min；40-45 DEG C is cooled to, potassium hydroxide is added, stirring is equal
It is even；Whitening, spot plant composition, preservative described in adding claim 1, stir, obtain whitening cream.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108066189A (en) * | 2017-12-19 | 2018-05-25 | 北京明弘科贸有限责任公司 | There is the anti-ageing ganoderma lucidum skin care compositions for dispelling yellow and its application |
| CN108210433A (en) * | 2018-01-17 | 2018-06-29 | 北京明弘科贸有限责任公司 | Cardamom skin care compositions and its application with oil-control and/or acne-removing |
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| CN109820774A (en) * | 2018-12-10 | 2019-05-31 | 横琴智库转化医学有限公司 | A kind of whitening spot-removing moisturiser and preparation method thereof containing Chinese medicine |
| CN115364027A (en) * | 2022-09-05 | 2022-11-22 | 宁波鄞州梵韵医疗美容诊所有限公司 | Plant endogenous combined speckle-lightening composite preparation, preparation method and application thereof |
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