CN110101636A - A kind of kojic acid freckle removing and whitening frost and preparation method thereof - Google Patents

A kind of kojic acid freckle removing and whitening frost and preparation method thereof Download PDF

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Publication number
CN110101636A
CN110101636A CN201910472577.5A CN201910472577A CN110101636A CN 110101636 A CN110101636 A CN 110101636A CN 201910472577 A CN201910472577 A CN 201910472577A CN 110101636 A CN110101636 A CN 110101636A
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parts
kojic acid
weight
freckle removing
ginger
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李镇江
杨志刚
唐晓芳
杨晓琴
黄伟
饶航
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CHENGDU JINKAI BIOLOGICAL ENGINEERING Co Ltd
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CHENGDU JINKAI BIOLOGICAL ENGINEERING Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • A61K8/345Alcohols containing more than one hydroxy group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4946Imidazoles or their condensed derivatives, e.g. benzimidazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A61K8/498Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60Sugars; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/735Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9794Liliopsida [monocotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005Antimicrobial preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/02Preparations for care of the skin for chemically bleaching or whitening the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/82Preparation or application process involves sonication or ultrasonication
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/84Products or compounds obtained by lyophilisation, freeze-drying

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Abstract

The invention discloses a kind of kojic acid freckle removing and whitening frost, the raw materials including following composition by weight ratio: 1-5 parts of sesame, 2-5 parts of Jojoba, 4-8 parts of aloe, 1-3 parts of ginger, 4-8 parts of trehalose, 1-5 parts of kojic acid, 2-4 parts of Radix Angelicae Sinensis seed, 3-6 parts of cinnamomum japonicum, 10-15 parts of sodium hyaluronate, 1-5 parts of glycerol;3-8 parts of methyl hydroxybenzoate, 4-8 parts of cetyl-PG hydroxyethyl palmitamide, 1-4 parts of rhizome of chuanxiong, 1-3 parts of allantoin, 10-15 parts of calendula extract and 25-35 parts of deionized water.The advantages of with being added into skin whitener, whitening, despeckle, restraining and sterilizing bacteria can be reached in daily skin care using advanced fruit of bio-technology kojic acid as raw material.The invention also discloses a kind of preparation methods of kojic acid freckle removing and whitening frost.

Description

A kind of kojic acid freckle removing and whitening frost and preparation method thereof
Technical field
The present invention relates to technical field of skin care, it particularly relates to a kind of kojic acid freckle removing and whitening frost and preparation method thereof.
Background technique
Kojic acid is a kind of colourless, tasteless, safe and non-toxic tyrosinase inhibitor that microorganism generates, black to human skin The generation of pigment has very strong inhibiting effect, is a kind of melanin specificity inhibitor, it enters energy and cell after Skin Cell In copper ion complexing, change the stereochemical structure of tyrosinase, prevent the activity of tyrosinase, to inhibit the shape of melanin At.The more other whitening active agent of kojic acid class whitening active agent have better tyrosinase inhibitory effect.It does not act on cell In other biological enzyme, there is no toxic action to cell, while it also can enter in cytoplasm, form intercellular colloid, play Water conservation and the effect for increasing skin elasticity, and it is safe and nontoxic, hickie sequelae will not be generated, it is each by extensive supplying at present In kind cosmetics, such as toner, facial mask, lotion, cream, freckle, senile plaque, pigmentation and acne can be effectively treated, and It is deep especially to be had liking for color spot young women by consumer as the advanced cosmetics of international fashion, in Japan, have compared with More skin care item containing kojic acid.
But kojic acid is oxidized easily in air, makes its color by leucismus Huang in white skin care item, until deep orange Color seriously affects consumer to the worry of product quality.Because kojic acid changes colour, kojic acid class skin care item sales volume, Yi Xiechang are influenced Family replaces in order to which other chemical classes whitening agents are added in interests, but there are security risks.Other producers are added in kojic acid product Dark pigment makes product change colour in use and feels unobvious, but pigment is also harmful to human body.
Summary of the invention
To solve problems of the prior art, the present invention provides a kind of kojic acid freckle removing and whitening frost and preparation method thereof, With using advanced fruit of bio-technology kojic acid as raw material, be added into skin whitener, can reach in daily skin care whitening, The advantages of despeckle, restraining and sterilizing bacteria.
To achieve the above object, the technical solution adopted by the present invention is that: a kind of kojic acid freckle removing and whitening frost, including following weight The raw material of component ratio: 1-5 parts of sesame, 2-5 parts of Jojoba, 4-8 parts of aloe, 1-3 parts of ginger, 4-8 parts of trehalose, 1-5 parts of kojic acid, 2-4 parts of Radix Angelicae Sinensis seed, 3-6 parts of cinnamomum japonicum, 10-15 parts of sodium hyaluronate, 1-5 parts of glycerol;3-8 parts of methyl hydroxybenzoate, cetyl-PG hydroxyl second 4-8 parts of base palmitamide, 1-4 parts of rhizome of chuanxiong, 1-3 parts of allantoin, 10-15 parts of calendula extract and 25-35 parts of deionized water.
Preferably, which includes the raw material of following composition by weight ratio: 1 part of sesame, 2 parts of Jojoba, reed 4 parts of luxuriant growth, 1 part of ginger, 4 parts of trehalose, 1 part of kojic acid, 2 parts of Radix Angelicae Sinensis seed, 3 parts of cinnamomum japonicum, 10 parts of sodium hyaluronate, 1 part of glycerol;Oxybenzene 3 parts of methyl esters, 4 parts of cetyl-PG hydroxyethyl palmitamide, 1 part of rhizome of chuanxiong, 1 part of allantoin, 10 parts of calendula extract and deionization 25 parts of water.
Preferably, which includes the raw material of following composition by weight ratio: 3 parts of sesame, 3.5 parts of Jojoba, 6 parts of aloe, 2 parts of ginger, 6 parts of trehalose, 3 parts of kojic acid, 3 parts of Radix Angelicae Sinensis seed, 4.5 parts of cinnamomum japonicum, 12.5 parts of sodium hyaluronate, glycerol 3 Part;5.5 parts of methyl hydroxybenzoate, 6 parts of cetyl-PG hydroxyethyl palmitamide, 2.5 parts of rhizome of chuanxiong, 2 parts of allantoin, calendula extract 12.5 parts and 30 parts of deionized water.
Preferably, 5 parts of the kojic acid freckle removing and whitening frost sesame, 5 parts of Jojoba, 8 parts of aloe, 3 parts of ginger, 8 parts of trehalose, song Sour 5 parts, 4 parts of Radix Angelicae Sinensis seed, 6 parts of cinnamomum japonicum, 15 parts of sodium hyaluronate, 5 parts of glycerol;8 parts of methyl hydroxybenzoate, cetyl-PG ethoxy palm fibre 8 parts of palmitic acid amide, 4 parts of rhizome of chuanxiong, 3 parts of allantoin, 15 parts of calendula extract and 35 parts of deionized water.
A kind of preparation method of kojic acid freckle removing and whitening frost, the kojic acid freckle removing and whitening frost include the original of following composition by weight ratio Material: 1-5 parts of sesame, 2-5 parts of Jojoba, 4-8 parts of aloe, 1-3 parts of ginger, 4-8 parts of trehalose, 1-5 parts of kojic acid, Radix Angelicae Sinensis seed 2-4 Part, 3-6 parts of cinnamomum japonicum, 10-15 parts of sodium hyaluronate, 1-5 parts of glycerol;3-8 parts of methyl hydroxybenzoate, cetyl-PG ethoxy palmityl 4-8 parts of amine, 1-4 parts of rhizome of chuanxiong, 1-3 parts of allantoin, 10-15 parts of calendula extract and 25-35 parts of deionized water;Including walking as follows It is rapid:
S10, the sesame for taking 1-5 parts by weight, the Radix Angelicae Sinensis seed of 2-4 parts by weight, the cinnamomum japonicum of 3-6 parts by weight and 2-5 parts by weight Jojoba, carry out oil expression processing, obtain sesame oil, angelica seed oil, India oil of bay and SIMMONDSIA CHINENSIS SEED OIL;
S20, the rhizome of chuanxiong of the aloe of 4-8 parts by weight, the ginger of 1-3 parts by weight and 1-4 parts by weight is separately added into deionization Water impregnates 45-60 minutes under 65-80 degrees Celsius of water temperature, merges boil liquid after decocting 2h and filters, oxybenzene first is added in filtrate It is impregnated in ester solution, then carries out ultrasound-microwave auxiliary extraction, be freeze-dried extraction filter vacuum to obtain extract;
S30, by the trehalose of 4-8 parts by weight, the kojic acid of 1-5 parts by weight, the sodium hyaluronate of 10-15 parts by weight, 1-5 weight Part glycerol, the cetyl-PG hydroxyethyl palmitamide of 4-8 parts by weight, the allantoin of 1-3 parts by weight and 10-15 parts by weight Calendula extract carries out being mixed to get the first mixed liquor;
S40, sesame oil made from step S10, angelica seed oil, India oil of bay and He He are sequentially added in the first mixed liquor Bar oil, after being mixed, obtains the second mixed liquor;
S50, extract obtained in the trehalose and step S20 of 4-8 parts by weight is sequentially added in the second mixed liquor, into After row mixing, third mixed liquor is obtained;
S60, the allantoin that 1-3 parts by weight are sequentially added in third mixed liquor and 10-15 calendula extract, mixing are stirred After mixing 45-60 minutes, 24-48 hours are stood to get finished product is arrived.
Preferably, further comprising the steps of before step S20:
S201, aloe, ginger and rhizome of chuanxiong are cleaned;
S202, the epidermis for removing aloe and ginger.
Preferably, incorporation time when step S30 is mixed is 30-45 minutes, mixing velocity 30-75r/min.
Preferably, the incorporation time in step S40 and step S50 is 20-35 minutes, mixing velocity 100-150r/ min。
Preferably, further comprising the steps of in step S60:
After being mixed 45-60 minutes, mixed solution is filtered, and sterilization processing is carried out to mixed solution, then stand 24-48 hours.
Preferably, the sterilization processing is ultraviolet sterilization or ultrasonic sterilization.
The beneficial effects of the present invention are:
(1) it using advanced fruit of bio-technology kojic acid as raw material, is added into skin whitener, can be reached in daily skin care To whitening, despeckle, the effect of restraining and sterilizing bacteria.
(2) a variety of Chinese herbal medicine extracts of compatibility reduce the use of the fungicide and preservative of chemical industry synthesis class.
Specific embodiment
The embodiment of the present invention is described in detail below.
Embodiment 1:
A kind of kojic acid freckle removing and whitening frost, the raw material including following composition by weight ratio: 1-5 parts of sesame, 2-5 parts of Jojoba, reed 4-8 parts of luxuriant growth, 1-3 parts of ginger, 4-8 parts of trehalose, 1-5 parts of kojic acid, 2-4 parts of Radix Angelicae Sinensis seed, 3-6 parts of cinnamomum japonicum, sodium hyaluronate 10-15 Part, 1-5 parts of glycerol;3-8 parts of methyl hydroxybenzoate, 4-8 parts of cetyl-PG hydroxyethyl palmitamide, 1-4 parts of rhizome of chuanxiong, allantoin 1-3 Part, 10-15 parts of calendula extract and 25-35 parts of deionized water.
Embodiment 2:
On the basis of embodiment 1, which includes the raw material of following composition by weight ratio: sesame to the present embodiment Numb 1 part, 2 parts of Jojoba, 4 parts of aloe, 1 part of ginger, 4 parts of trehalose, 1 part of kojic acid, 2 parts of Radix Angelicae Sinensis seed, 3 parts of cinnamomum japonicum, Hyaluronic Acid 10 parts of sodium, 1 part of glycerol;3 parts of methyl hydroxybenzoate, 4 parts of cetyl-PG hydroxyethyl palmitamide, 1 part of rhizome of chuanxiong, 1 part of allantoin, golden small cup 10 parts and 25 parts of deionized water of flower extract.
Embodiment 3:
On the basis of embodiment 1, which includes the raw material of following composition by weight ratio: sesame to the present embodiment Numb 3 parts, 3.5 parts of Jojoba, 6 parts of aloe, 2 parts of ginger, 6 parts of trehalose, 3 parts of kojic acid, 3 parts of Radix Angelicae Sinensis seed, 4.5 parts of cinnamomum japonicum, glass 12.5 parts of glass acid sodium, 3 parts of glycerol;5.5 parts of methyl hydroxybenzoate, 6 parts of cetyl-PG hydroxyethyl palmitamide, 2.5 parts of rhizome of chuanxiong, allantois 2 parts of element, 12.5 parts of calendula extract and 30 parts of deionized water.
Embodiment 4:
On the basis of embodiment 1, which includes the raw material of following composition by weight ratio: sesame to the present embodiment Numb 5 parts, 5 parts of Jojoba, 8 parts of aloe, 3 parts of ginger, 8 parts of trehalose, 5 parts of kojic acid, 4 parts of Radix Angelicae Sinensis seed, 6 parts of cinnamomum japonicum, Hyaluronic Acid 15 parts of sodium, 5 parts of glycerol;8 parts of methyl hydroxybenzoate, 8 parts of cetyl-PG hydroxyethyl palmitamide, 4 parts of rhizome of chuanxiong, 3 parts of allantoin, golden small cup 15 parts and 35 parts of deionized water of flower extract.
Sesame: vitamin E rich in sesame can prevent the harm of lipid peroxidation confrontation skin, offset or neutralize The accumulation of intracellular harmful substance free radical, it is moist can to make whitening skin, and can prevent various scytitis;
Jojoba: He Heba contains abundant vitamin D and protein, is good moist and moisturizing oil, can safeguard skin Moisture, pre- anti-wrinkle and softening skin are suitble to mature and aging skin, are usually used in the maintenance of face, body massage and hair;
Aloe: the cross that the polysaccharide and multivitamin contained in aloe has good nutrition to human skin, grows aloe leaf The cross section profit of section aloe leaf, whitening effect.Aloe barbadensis Miller is the Fresh leaf of aloe of the direct beauty of optimum, i.e. Curacao reed Luxuriant growth, it have make skin contraction, softness, the performance of moisturizing, anti-inflammatory, bleaching.There are also release hardening, angling, improve scar Effect, can not only prevent small wrinkle, eye pouch, cutis laxa, moreover it is possible to skin wet, delicate be kept, at the same time it can also treat skin Inflammation also has good curative effect to acne, freckle, acne and scald, knife wound, insect bite etc.;
Ginger: the structure of gingerol and diarylheptanoids contained in ginger all have it is very strong it is anti-oxidant and Effect of scavenging radical;
Trehalose: algae sugar has excellent holding cell viability and the active characteristic of large biological molecule, can be in cell table Layer forms one layer of special protective film, and the mucus being precipitated from film not only moistens Skin Cell, also has external heat The function radiateing;
Kojic acid: kojic acid can inhibit the synthesis of tyrosinase, thus can be with the formation of strong inhibition dermal melanin, Er Qiean Atoxic will not generate hickie sequelae;
Radix Angelicae Sinensis seed: although Chinese medicine thinks pernio disease on the skin, mostly ferritic YANG QI deficiency, exogeneous cold are invaded in fact, yang-energy Do not stretch, blood stasis due to accumulation of cold and cause.Therefore treatment on frequently with it is warming channel and expelling cold, activate blood circulation and disperse blood clots, swelling and pain relieving.Chinese angelica, ginger mutton soup goes out From " Treatise on Febrile and Miscellaneous Disease ".Chinese Angelica blood replonishing is invigorated blood circulation in side, ginger warming yang for dispelling cold, mutton qi-restoratives green blood, full side's mutual aid nourshing blood and promoting blood circulation, temperature The benefits of positive cold dispelling;
Cinnamomum japonicum: the branches and leaves and bark of cinnamomum japonicum can extract aromatic oil, for making the raw material of various essence and fragrance;
Sodium hyaluronate: hyaluronidase be it is a kind of can glass hydrolytic acid enzyme (in periplast have limit moisture and its The ingredient of the effect of his extracellular substances diffusion), the diffusate of hypodermoclysis or local repertory or blood can be promoted to accelerate diffusion And it is conducive to absorb;
Glycerol: colourless, transparent, odorless, thick liquid, it is sweet, there is hygroscopicity;
Methyl hydroxybenzoate is sterilization antiseptic;
Cetyl-PG hydroxyethyl palmitamide: have the function of skin condition, whitening spot-removing;
Rhizome of chuanxiong: have the function of antibacterial;
Allantoin and pot marigold: has the function of antiallergic of releiving.
Embodiment 5:
A kind of preparation method of kojic acid freckle removing and whitening frost, the kojic acid freckle removing and whitening frost include the original of following composition by weight ratio Material: 1-5 parts of sesame, 2-5 parts of Jojoba, 4-8 parts of aloe, 1-3 parts of ginger, 4-8 parts of trehalose, 1-5 parts of kojic acid, Radix Angelicae Sinensis seed 2-4 Part, 3-6 parts of cinnamomum japonicum, 10-15 parts of sodium hyaluronate, 1-5 parts of glycerol;3-8 parts of methyl hydroxybenzoate, cetyl-PG ethoxy palmityl 4-8 parts of amine, 1-4 parts of rhizome of chuanxiong, 1-3 parts of allantoin, 10-15 parts of calendula extract and 25-35 parts of deionized water;Including walking as follows It is rapid:
S10, the sesame for taking 1-5 parts by weight, the Radix Angelicae Sinensis seed of 2-4 parts by weight, the cinnamomum japonicum of 3-6 parts by weight and 2-5 parts by weight Jojoba, carry out oil expression processing, obtain sesame oil, angelica seed oil, India oil of bay and SIMMONDSIA CHINENSIS SEED OIL;
S20, the rhizome of chuanxiong of the aloe of 4-8 parts by weight, the ginger of 1-3 parts by weight and 1-4 parts by weight is separately added into deionization Water impregnates 45-60 minutes under 65-80 degrees Celsius of water temperature, merges boil liquid after decocting 2h and filters, oxybenzene first is added in filtrate It is impregnated in ester solution, then carries out ultrasound-microwave auxiliary extraction, be freeze-dried extraction filter vacuum to obtain extract;
S30, by the trehalose of 4-8 parts by weight, the kojic acid of 1-5 parts by weight, the sodium hyaluronate of 10-15 parts by weight, 1-5 weight Part glycerol, the cetyl-PG hydroxyethyl palmitamide of 4-8 parts by weight, the allantoin of 1-3 parts by weight and 10-15 parts by weight Calendula extract carries out being mixed to get the first mixed liquor;
S40, sesame oil made from step S10, angelica seed oil, India oil of bay and He He are sequentially added in the first mixed liquor Bar oil, after being mixed, obtains the second mixed liquor;
S50, extract obtained in the trehalose and step S20 of 4-8 parts by weight is sequentially added in the second mixed liquor, into After row mixing, third mixed liquor is obtained;
S60, the allantoin that 1-3 parts by weight are sequentially added in third mixed liquor and 10-15 calendula extract, mixing are stirred After mixing 45-60 minutes, 24-48 hours are stood to get finished product is arrived.
Embodiment 6:
The present embodiment is on the basis of embodiment 1, further comprising the steps of before step S20:
S201, aloe, ginger and rhizome of chuanxiong are cleaned;
S202, the epidermis for removing aloe and ginger.
Embodiment 7:
On the basis of embodiment 1, incorporation time when step S30 is mixed is 30-45 minutes to the present embodiment, mixing velocity For 30-75r/min.
Embodiment 8:
On the basis of embodiment 1, the incorporation time in step S40 and step S50 is 20-35 minutes to the present embodiment, is mixed Conjunction speed is 100-150r/min.
Embodiment 9:
The present embodiment is on the basis of embodiment 1, further comprising the steps of in step S60:
After being mixed 45-60 minutes, mixed solution is filtered, and sterilization processing is carried out to mixed solution, then stand 24-48 hours.
Embodiment 10:
On the basis of embodiment 1, the sterilization processing is ultraviolet sterilization or ultrasonic sterilization to the present embodiment.
A specific embodiment of the invention above described embodiment only expresses, the description thereof is more specific and detailed, but simultaneously Limitations on the scope of the patent of the present invention therefore cannot be interpreted as.It should be pointed out that for those of ordinary skill in the art For, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to guarantor of the invention Protect range.

Claims (10)

1. a kind of kojic acid freckle removing and whitening frost, which is characterized in that the raw material including following composition by weight ratio: 1-5 parts of sesame, Jojoba 2-5 parts, 4-8 parts of aloe, 1-3 parts of ginger, 4-8 parts of trehalose, 1-5 parts of kojic acid, 2-4 parts of Radix Angelicae Sinensis seed, 3-6 parts of cinnamomum japonicum, glass Sour sodium 10-15 parts, 1-5 parts of glycerol;3-8 parts of methyl hydroxybenzoate, 4-8 parts of cetyl-PG hydroxyethyl palmitamide, 1-4 parts of rhizome of chuanxiong, urine 1-3 parts of Bursin, 10-15 parts of calendula extract and 25-35 parts of deionized water.
2. kojic acid freckle removing and whitening frost according to claim 1, which is characterized in that the kojic acid freckle removing and whitening frost includes following weight Measure component ratio raw material: 1 part of sesame, 2 parts of Jojoba, 4 parts of aloe, 1 part of ginger, 4 parts of trehalose, 1 part of kojic acid, 2 parts of Radix Angelicae Sinensis seed, 3 parts of cinnamomum japonicum, 10 parts of sodium hyaluronate, 1 part of glycerol;3 parts of methyl hydroxybenzoate, 4 parts of cetyl-PG hydroxyethyl palmitamide, rhizome of chuanxiong 1 Part, 1 part of allantoin, 10 parts of calendula extract and 25 parts of deionized water.
3. kojic acid freckle removing and whitening frost according to claim 1, which is characterized in that the kojic acid freckle removing and whitening frost includes following weight Measure the raw material of component ratio: 3 parts of sesame, 3.5 parts of Jojoba, 6 parts of aloe, 2 parts of ginger, 6 parts of trehalose, 3 parts of kojic acid, Radix Angelicae Sinensis seed 3 Part, 4.5 parts of cinnamomum japonicum, 12.5 parts of sodium hyaluronate, 3 parts of glycerol;5.5 parts of methyl hydroxybenzoate, cetyl-PG hydroxyethyl palmitamide 6 Part, 2.5 parts of rhizome of chuanxiong, 2 parts of allantoin, 12.5 parts of calendula extract and 30 parts of deionized water.
4. kojic acid freckle removing and whitening frost according to claim 1, which is characterized in that 5 parts of the kojic acid freckle removing and whitening frost sesame, lotus It is 5 parts of lotus bar, 8 parts of aloe, 3 parts of ginger, 8 parts of trehalose, 5 parts of kojic acid, 4 parts of Radix Angelicae Sinensis seed, 6 parts of cinnamomum japonicum, 15 parts of sodium hyaluronate, sweet 5 parts of oil;8 parts of methyl hydroxybenzoate, 8 parts of cetyl-PG hydroxyethyl palmitamide, 4 parts of rhizome of chuanxiong, 3 parts of allantoin, calendula extract 15 Part and 35 parts of deionized water.
5. a kind of preparation method of kojic acid freckle removing and whitening frost, the kojic acid freckle removing and whitening frost include the raw material of following composition by weight ratio: 1-5 parts of sesame, 2-5 parts of Jojoba, 4-8 parts of aloe, 1-3 parts of ginger, 4-8 parts of trehalose, 1-5 parts of kojic acid, 2-4 parts of Radix Angelicae Sinensis seed, 3-6 parts of cinnamomum japonicum, 10-15 parts of sodium hyaluronate, 1-5 parts of glycerol;3-8 parts of methyl hydroxybenzoate, cetyl-PG hydroxyethyl palmitamide 4- 8 parts, 1-4 parts of rhizome of chuanxiong, 1-3 parts of allantoin, 10-15 parts of calendula extract and 25-35 parts of deionized water;It is characterized in that, packet Include following steps:
The lotus of S10, the sesame for taking 1-5 parts by weight, the Radix Angelicae Sinensis seed of 2-4 parts by weight, the cinnamomum japonicum of 3-6 parts by weight and 2-5 parts by weight Lotus bar carries out oil expression processing, obtains sesame oil, angelica seed oil, India oil of bay and SIMMONDSIA CHINENSIS SEED OIL;
S20, the rhizome of chuanxiong of the aloe of 4-8 parts by weight, the ginger of 1-3 parts by weight and 1-4 parts by weight is separately added into deionized water, It impregnates 45-60 minutes, merge boil liquid after decocting 2h and filters under 65-80 degrees Celsius of water temperature, it is molten that methyl hydroxybenzoate is added in filtrate It is impregnated in liquid, then carries out ultrasound-microwave auxiliary extraction, be freeze-dried extraction filter vacuum to obtain extract;
S30, by the trehalose of 4-8 parts by weight, the kojic acid of 1-5 parts by weight, the sodium hyaluronate of 10-15 parts by weight, 1-5 parts by weight Glycerol, the cetyl-PG hydroxyethyl palmitamide of 4-8 parts by weight, the allantoin of 1-3 parts by weight and the golden small cup of 10-15 parts by weight Flower extract carries out being mixed to get the first mixed liquor;
S40, sesame oil made from step S10, angelica seed oil, India oil of bay and Jojoba are sequentially added in the first mixed liquor Oil after being mixed, obtains the second mixed liquor;
S50, extract obtained in the trehalose and step S20 of 4-8 parts by weight is sequentially added in the second mixed liquor, mixed After conjunction, third mixed liquor is obtained;
S60, the allantoin and 10-15 calendula extract that 1-3 parts by weight are sequentially added in third mixed liquor are mixed After 45-60 minutes, 24-48 hours are stood to get finished product is arrived.
6. the preparation method of kojic acid freckle removing and whitening frost according to claim 5, which is characterized in that before step S20 also The following steps are included:
S201, aloe, ginger and rhizome of chuanxiong are cleaned;
S202, the epidermis for removing aloe and ginger.
7. the preparation method of kojic acid freckle removing and whitening frost according to claim 5, which is characterized in that when step S30 is mixed Incorporation time is 30-45 minutes, mixing velocity 30-75r/min.
8. the preparation method of kojic acid freckle removing and whitening frost according to claim 5, which is characterized in that step S40 and step S50 In incorporation time be 20-35 minutes, mixing velocity 100-150r/min.
9. the preparation method of kojic acid freckle removing and whitening frost according to claim 5, which is characterized in that also wrapped in step S60 Include following steps:
After being mixed 45-60 minutes, mixed solution is filtered, and sterilization processing is carried out to mixed solution, then stand 24-48 Hour.
10. the preparation method of kojic acid freckle removing and whitening frost according to claim 9, which is characterized in that the sterilization processing is Ultraviolet sterilization or ultrasonic sterilization.
CN201910472577.5A 2019-05-31 2019-05-31 A kind of kojic acid freckle removing and whitening frost and preparation method thereof Pending CN110101636A (en)

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1895211A (en) * 2006-06-07 2007-01-17 卢藏田 Composite whitening spot-dispelling liquid and its production
CN103462845A (en) * 2013-09-12 2013-12-25 广东轻工职业技术学院 Composite whitening and banishing essence and preparation method thereof
CN108158931A (en) * 2018-03-26 2018-06-15 广东盛美化妆品有限公司 A kind of moisturizing whitening cream of the extract containing Flos micheliae Albae and preparation method thereof
CN108451874A (en) * 2018-05-14 2018-08-28 成都金开生物工程有限公司 Kojic acid whitening bacterium-suppressing shower lotion and preparation method thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1895211A (en) * 2006-06-07 2007-01-17 卢藏田 Composite whitening spot-dispelling liquid and its production
CN103462845A (en) * 2013-09-12 2013-12-25 广东轻工职业技术学院 Composite whitening and banishing essence and preparation method thereof
CN108158931A (en) * 2018-03-26 2018-06-15 广东盛美化妆品有限公司 A kind of moisturizing whitening cream of the extract containing Flos micheliae Albae and preparation method thereof
CN108451874A (en) * 2018-05-14 2018-08-28 成都金开生物工程有限公司 Kojic acid whitening bacterium-suppressing shower lotion and preparation method thereof

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