CN1895211A - Composite whitening spot-dispelling liquid and its production - Google Patents
Composite whitening spot-dispelling liquid and its production Download PDFInfo
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- CN1895211A CN1895211A CN 200610035831 CN200610035831A CN1895211A CN 1895211 A CN1895211 A CN 1895211A CN 200610035831 CN200610035831 CN 200610035831 CN 200610035831 A CN200610035831 A CN 200610035831A CN 1895211 A CN1895211 A CN 1895211A
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Abstract
A composite spot-removing liquid for removing senile plaque, chloasma, ephelides, etc and beautifying and whitening skin is prepared from 24 Chinese-medicinal materials including liquorice root, ginseng, mulberry bark, aloe, etc and 9 other raw materials including konjic acid, VA, caffeic acid, VB3, etc. Its preparing process is also disclosed.
Description
Technical field:
The invention belongs to a kind of whitening anti-freckle agent, relate in particular to a kind of FUHE MEIBAI QUBAN YE.
Technical background:
Freckle, chloasma, butterfly spot, cyasma, comedo speckle, senile plaque etc. are that a large amount of melanin are in the uneven a kind of common skin phenomenon of human body deposition distribution, studies show that the woman will produce after 20 years old in a large number, this has brought great social mentality pressure to people.The formation mechanism of skin splash is intricate, and main inducing is divided into health extrinsic factor and health intrinsic factor.The health extrinsic factor mainly contains: ultraviolet shines excessively, uses that maintenance such as cosmetics inferior is improper, chemical drugs corrosion etc.; The health intrinsic factor mainly contain: diseases such as chronic liver sausage stomach cause endocrine regulation, heredity, metabolism of pigment is not normal, the age increases etc.The method that solves the problem of above-mentioned mottle mainly is: remove free oxygen free radical in cortex and the body, the activity of restraint of tyrosinase is regulated human endocrine and substance metabolism.The product of whitening and speckle dispelling is extremely many on the market at present, and its contained main whitening and speckle dispelling active component is mostly: hydroquinone and derivant thereof (arbutin), mercury compound (hydroquinone), vitamin C, vitamin A and derivant thereof, kojic acid etc.There is following problem in these products: (1) can only be effective to some mottle, and speckle dispelling can not be comprehensive, and it is slow to take effect.(2) speckle dispelling can not be thorough, easily recurrence.(3) skin is existed stimulation and infringement, the cosmetics of mercurous class more can cause intoxicating phenomenon.
Summary of the invention:
The objective of the invention is to solve the problem that existing whitening and speckle dispelling product exists, provide a kind of curative effect comprehensively, thoroughly, the FUHE MEIBAI QUBAN YE that has no side effect of instant effect.
FUHE MEIBAI QUBAN YE of the present invention is achieved in that a kind of FUHE MEIBAI QUBAN YE, and its raw material weight umber is: plant water-soluble extract 10-25, kojic acid 1-5, vitamin A 1-5, caffeic acid 1-5, L-vitamin C 0.5-5, ferulic acid 0.5-5, vitamin B3 0.5-5, propylene glycol 1-10, hyaluronic acid 0.05-0.5, trimethyl glycine 1-10, water solublity ceramide 0.5-5, Methyl p-hydroxybenzoate 0.2-0.6, Tween-40 0.2-0.8, deionized water 40-60; Wherein, described plant water-soluble extract raw material weight umber is: the Radix Angelicae Dahuricae 5～15, Radix Glycyrrhizae 5-25, Radix Ginseng 5-15, Cortex Mori 5-20, Folium Vaccinii vitis-idaeae 10-35, Rhizoma Chuanxiong 10-25, Radix Saposhnikoviae 5-30, flower of mustard 5-35, Aloe 10-30, Radix Salviae Miltiorrhizae 5-25, Radix Scutellariae 10-40, Cortex Pini 8-25, Radix Angelicae Sinensis 5-25, Ganoderma 5-20, Semen Ginkgo 10-30, Semen Ginkgo 5-20, Fructus Gardeniae 5-25, Radix Polygoni Multiflori 5-15, Radix Puerariae 5-15, Fructus Schisandrae Chinensis 5-20, Rhizoma Gastrodiae 5-15, Olibanum 5-18, Rhizoma Coptidis 5-15, Radix Codonopsis 8-20.
FUHE MEIBAI QUBAN YE manufacture method of the present invention is achieved in that (1) at first is the extracting method of plant water-soluble extract: with parts by weight be: the Radix Angelicae Dahuricae 5～15, Radix Glycyrrhizae 5-25, Radix Ginseng 5-15, Cortex Mori 5-20, Folium Vaccinii vitis-idaeae 10-35, Rhizoma Chuanxiong 10-25, Radix Saposhnikoviae 5-30, flower of mustard 5-35, Aloe 10-30, Radix Salviae Miltiorrhizae 5-25, Radix Scutellariae 10-40, Cortex Pini 8-25, Radix Angelicae Sinensis 5-25, Ganoderma 5-20, Semen Ginkgo 10-30, Semen Ginkgo 5-20, Fructus Gardeniae 5-25, Radix Polygoni Multiflori 5-15, Radix Puerariae 5-15, Fructus Schisandrae Chinensis 5-20, Rhizoma Gastrodiae 5-15, Olibanum 5-18, Rhizoma Coptidis 5-15, Radix Codonopsis 8-20 is soaked in the ethanol of 55%-65% with 1: 5 to 1: 7 ratio, soak time is 25～35 days, decoct then, change slow fire into after elder generation's intense fire boiling, can hang the palm (solution droplets can be attached to planar object surface and do not drip) time and stop when decocting the solution that is concentrated in the pot, cooled and filtered, the filtrate of collecting gained is the plant water-soluble extract, and its effective ingredient concentration is more than 80%; (2) with parts by weight be: plant water-soluble extract 10-25, kojic acid 1-5, vitamin A 1-5, caffeic acid 1-5, L-vitamin C 0.5-5, ferulic acid 0.5-5, vitamin B3 0.5-5, propylene glycol 1-10, hyaluronic acid 0.05-0.5, amino acid humectant 1-10, water solublity ceramide 0.5-5 add among the deionized water 40-60 successively while stirring, restir 10-20 minute afterwards; (3) adding Methyl p-hydroxybenzoate 0.2-0.6, Tween-40 0.2-0.8 stirs; (4) ultraviolet disinfection 40-60 minute, filter, leave standstill and got product in 20-24 hour.
FUHE MEIBAI QUBAN YE outward appearance of the present invention is the yellow translucent liquid of succinum, and abnormal smells from the patient is slight, and pH value is 4.5～6.0.The product of gained of the present invention answers sealed storage in 15～25 ℃ of exsiccant environment in cool place, avoids being subjected to the direct irradiation of light.FUHE MEIBAI QUBAN YE of the present invention can directly be diluted about 10% and made water preparation and directly be applied in patient part, also can be used to make cream frost, essence, emulsion etc.
FUHE MEIBAI QUBAN YE of the present invention is the combination of plurality of Chinese composition and whitening and speckle dispelling active component.Wherein, Radix Glycyrrhizae, Folium Vaccinii vitis-idaeae, Rhizoma Chuanxiong, Radix Scutellariae, the Radix Angelicae Dahuricae, Radix Saposhnikoviae, flower of mustard extract have the activity of potent reduction and restraint of tyrosinase, effectively prevent melanic generation and over-deposit, simultaneously can also effectively decompose, reduce the melanin that in skin, forms; Radix Ginseng, Radix Salviae Miltiorrhizae extract can effectively hinder melanic biosynthesis, have the very function of strong anti-oxidation simultaneously; Radix Scutellariae, Semen Ginkgo, Semen Ginkgo, Fructus Gardeniae extract are efficiently to impel the reductive material of melanin; Olibanum, Rhizoma Gastrodiae extract are the melanocyte cytotoxic drugs, and the ability of the growth of extremely strong prevention melanocyte is arranged; Aloe, Cortex Pini Massonianae extract have strong antioxidant activity, efficiently remove oxygen-derived free radicals; Radix Angelicae Sinensis, Radix Puerariae, Fructus Schisandrae Chinensis, Radix Codonopsis, Radix Polygoni Multiflori, Ganoderma extract can be regulated substance metabolism and endocrine, increase skin elasticity; The Rhizoma Coptidis extract has the germ-resistant effect of antiinflammatory; Kojic acid, caffeic acid, ferulic acid have the activity of extremely strong restraint of tyrosinase, can effectively suppress melanic generation, the melanin that desalination has formed; Vitamin A, L-vitamin C, vitamin B3 have the active function of extremely strong restraint of tyrosinase, have skin care simultaneously, strengthen the function of skin immunization power; Hyaluronic acid, trimethyl glycine, water solublity ceramide have the effect of potent maintenance moisture of skin and reparation.
The theory that FUHE MEIBAI QUBAN YE application Chinese and western medicine of the present invention combines has been added multiple pure Chinese medicine ingredients in the whitening and speckle dispelling active matter, by active ingredient of Chinese herbs and the collaborative mutually effect of other whitening and speckle dispelling active matters, it is the activity of restraint of tyrosinase effectively, the efficient oxygen-derived free radicals of removing, prevent melanic generation, decompose the melanin that desalination has formed, can regulate simultaneously the hormonal system of human body, repair because the damage that the Western medicine chemical constituent causes skin in speckle dispelling.Thereby reach comprehensively fast, the effect for the treatment of both the principal and secondary aspects of a disease is avoided the outbreak repeatedly of mottle.FUHE MEIBAI QUBAN YE of the present invention does not contain the human body noxious substance simultaneously, is a kind of safe natural green product.
The specific embodiment:
Following component unit all is parts by weight.
Embodiment 1:
Plant water-soluble extract 10, kojic acid 5, retinol1, caffeic acid 5, L-vitamin C5, ferulic acid 0.5, vitamin B3 0.5, propylene glycol 10, hyaluronic acid 0.05, trimethyl glycine 1, water solublity ceramide 0.5, Methyl p-hydroxybenzoate 0.2, Tween-40 0.2, deionized water 40; Wherein, described plant water-soluble extract raw material weight mark: the Radix Angelicae Dahuricae 5, Radix Glycyrrhizae 5, Radix Ginseng 15, Cortex Mori 20, Folium Vaccinii vitis-idaeae 35, Rhizoma Chuanxiong 10, Radix Saposhnikoviae 30, flower of mustard 5, Aloe 10, Radix Salviae Miltiorrhizae 25, Radix Scutellariae 40, Cortex Pini 8, Radix Angelicae Sinensis 5, Ganoderma 20, Semen Ginkgo 10, Semen Ginkgo 5, Fructus Gardeniae 25, Radix Polygoni Multiflori 15, Radix Puerariae 5, Fructus Schisandrae Chinensis 20, Rhizoma Gastrodiae 5, Olibanum 18, Rhizoma Coptidis 5, Radix Codonopsis 8.
The FUHE MEIBAI QUBAN YE manufacture method of present embodiment is achieved in that (1) at first is the extracting method of plant water-soluble extract: with parts by weight be: the Radix Angelicae Dahuricae 5, Radix Glycyrrhizae 5, Radix Ginseng 15, Cortex Mori 20, Folium Vaccinii vitis-idaeae 35, Rhizoma Chuanxiong 10, Radix Saposhnikoviae 30, flower of mustard 5, Aloe 10, Radix Salviae Miltiorrhizae 25, Radix Scutellariae 40, Cortex Pini 8, Radix Angelicae Sinensis 5, Ganoderma 20, Semen Ginkgo 10, Semen Ginkgo 5, Fructus Gardeniae 25, Radix Polygoni Multiflori 15, Radix Puerariae 5, Fructus Schisandrae Chinensis 20, Rhizoma Gastrodiae 5, Olibanum 18, Rhizoma Coptidis 5, Radix Codonopsis 8 is soaked in 1: 7 ratio in 65% the ethanol, soak time is 25 to decoct after natural, change slow fire into after elder generation's intense fire boiling, stop when the solution that is concentrated in the pot can be hung the palm when decocting, cooled and filtered, the filtrate of collecting gained is the plant water-soluble extract; (2) with parts by weight be: plant water-soluble extract 10, kojic acid 5, retinol1, caffeic acid 5, L-vitamin C5, ferulic acid 0.5, vitamin B3 0.5, propylene glycol 10, hyaluronic acid 0.05, trimethyl glycine 1, water solublity ceramide 0.5 add in the deionized water 40 successively while stirring, and restir is 10 minutes afterwards; (3) adding Methyl p-hydroxybenzoate 0.2, Tween-40 0.2 stir; (4) ultraviolet disinfection is 40 minutes, filters, and leaves standstill to get product in 20 hours.
Embodiment 2:
Plant water-soluble extract 25, kojic acid 1, vitamin A 5, caffeic acid 1, L-vitamin C 0.5, ferulic acid 5, vitamin B3 5, propylene glycol 1, hyaluronic acid 0.5, trimethyl glycine 10, water solublity ceramide 5, Methyl p-hydroxybenzoate 0.6, Tween-40 0.8, deionized water 60; Wherein, the raw material weight mark of described plant water-soluble extract: the Radix Angelicae Dahuricae 15, Radix Glycyrrhizae 25, Radix Ginseng 5, Cortex Mori 5, Folium Vaccinii vitis-idaeae 10, Rhizoma Chuanxiong 25, Radix Saposhnikoviae 5, flower of mustard 35, Aloe 30, Radix Salviae Miltiorrhizae 5, Radix Scutellariae 10, Cortex Pini 25, Radix Angelicae Sinensis 25, Ganoderma 5, Semen Ginkgo 30, Semen Ginkgo 18, Fructus Gardeniae 10, Radix Polygoni Multiflori 5, Radix Puerariae 15, Fructus Schisandrae Chinensis 5, Rhizoma Gastrodiae 15, Olibanum 5, Rhizoma Coptidis 15, Radix Codonopsis 20.
The manufacture method of the described invention of present embodiment is substantially the same manner as Example 1, different except raw materials in part by weight, only be that concentration of ethanol is 55%, plant water-soluble extract raw material and alcoholic acid immersion ratio are 1: 5, soak time is 35 days, mixing time is 20 minutes, and ultraviolet disinfection 60 minutes left standstill 24 hours.
Embodiment 3:
Plant water-soluble extract 20, kojic acid 2,3-Hydroxyretinol, caffeic acid 2, L-vitamin C3, ferulic acid 3, vitamin B3 2, propylene glycol 6, hyaluronic acid 0.2, trimethyl glycine 5, water solublity ceramide 2, Methyl p-hydroxybenzoate 0.4, Tween-40 0.6, deionized water 50; Wherein, described plant water-soluble extract parts by weight of raw materials is: the Radix Angelicae Dahuricae 10, Radix Glycyrrhizae 20, Radix Ginseng 10, Cortex Mori 15, Folium Vaccinii vitis-idaeae 22, Rhizoma Chuanxiong 18, Radix Saposhnikoviae 24, flower of mustard 20, Aloe 23, Radix Salviae Miltiorrhizae 18, Radix Scutellariae 25, Cortex Pini 15, Radix Angelicae Sinensis 16, Ganoderma 15, Semen Ginkgo 20, Semen Ginkgo 16, Fructus Gardeniae 20, Radix Polygoni Multiflori 10, Radix Puerariae 11, Fructus Schisandrae Chinensis 15, Rhizoma Gastrodiae 8, Olibanum 14, Rhizoma Coptidis 10, Radix Codonopsis 15.
The manufacture method of the described invention of present embodiment is substantially the same manner as Example 1, different except raw materials in part by weight, only be that concentration of ethanol is 60%, the immersion ratio is that plant water-soluble extract raw material and alcoholic acid immersion ratio are 1: 6, soak time is 30 days, mixing time is 15 minutes, and ultraviolet disinfection is 50 minutes, and leaving standstill is 24 hours.
Methyl p-hydroxybenzoate is an antiseptic among the present invention, and Tween-40 is solubilizing agent.Wherein, concentration of ethanol the best is 60%, because if ethanol content is too low, extraction efficiency is just very low; Ethanol content is too high, and some active component is lost activity, and influences the effect of product.Grope to prove that through a large amount of experiments plant water-soluble extract raw material and alcoholic acid immersion ratio are 1: 6, the time is that 30 days effects are best.
The clinical trial example
Experimental subject: the age is 80 of the volunteers of 25-50, and wherein the male is 30.Their feature is a chloasma, senile plaque, butterfly spot, cyasma, freckle etc.
Method: the volunteer uses the cream frost that contains 15% FUHE MEIBAI QUBAN YE to smear the affected part every morning, and smear affected part with the essence that contains 15% composite whitening spot-dispelling evening; 28 days time.
Experimental result:
| Mottle disappears | Mottle is obviously desalinated | Mottle slightly improves | To no effect | Severity of symptoms | |
| Number | 76 | 2 | 1 | 1 | 0 |
Experimental result shows that 28 days total effective rates are 98.75%, cure rate 95%.The mottle rebound phenomena is not being taken place with the back in the trimestral observation in the volunteer.FUHE MEIBAI QUBAN YE of the present invention is at additional moisture of skin simultaneously, and delicate skin increases the skin elasticity aspect and also plays good result.
Claims (7)
1, a kind of FUHE MEIBAI QUBAN YE is characterized in that: its raw material weight umber is: plant water-soluble extract 10-25, kojic acid 1-5, vitamin A 1-5, caffeic acid 1-5, L-vitamin C 0.5-5, ferulic acid 0.5-5, vitamin B3 0.5-5, propylene glycol 1-10, hyaluronic acid 0.05-0.5, trimethyl glycine 1-10, water solublity ceramide 0.5-5, Methyl p-hydroxybenzoate 0.2-0.6, Tween-40 0.2-0.8, deionized water 40-60; Wherein, described plant water-soluble extract raw material weight umber is: the Radix Angelicae Dahuricae 5～15, Radix Glycyrrhizae 5-25, Radix Ginseng 5-15, Cortex Mori 5-20, Folium Vaccinii vitis-idaeae 10-35, Rhizoma Chuanxiong 10-25, Radix Saposhnikoviae 5-30, flower of mustard 5-35, Aloe 10-30, Radix Salviae Miltiorrhizae 5-25, Radix Scutellariae 10-40, Cortex Pini 8-25, Radix Angelicae Sinensis 5-25, Ganoderma 5-20, Semen Ginkgo 10-30, Semen Ginkgo 5-20, Fructus Gardeniae 5-25, Radix Polygoni Multiflori 5-15, Radix Puerariae 5-15, Fructus Schisandrae Chinensis 5-20, Rhizoma Gastrodiae 5-15, Olibanum 5-18, Rhizoma Coptidis 5-15, Radix Codonopsis 8-20.
2, the described FUHE MEIBAI QUBAN YE of claim 1, it is characterized in that: its raw materials in part by weight is: plant water-soluble extract 20, kojic acid 2, vitamin A 3, caffeic acid 2, L-vitamin C 3, ferulic acid 3, vitamin B3 2, propylene glycol 6, hyaluronic acid 0.2, trimethyl glycine 5, water solublity ceramide 2, Methyl p-hydroxybenzoate 0.4, Tween-40 0.6, deionized water 50; Wherein, described plant water-soluble extract raw material weight umber is: the Radix Angelicae Dahuricae 10, Radix Glycyrrhizae 20, Radix Ginseng 8, Cortex Mori 15, Folium Vaccinii vitis-idaeae 22, Rhizoma Chuanxiong 18, Radix Saposhnikoviae 24, flower of mustard 20, Aloe 23, Radix Salviae Miltiorrhizae 18, Radix Scutellariae 25, Cortex Pini 15, Radix Angelicae Sinensis 16, Ganoderma 15, Semen Ginkgo 20, Semen Ginkgo 16, Fructus Gardeniae 20, Radix Polygoni Multiflori 10, Radix Puerariae 11, Fructus Schisandrae Chinensis 15, Rhizoma Gastrodiae 8, Olibanum 14, Rhizoma Coptidis 10, Radix Codonopsis 15.
3, plant the manufacture method of FUHE MEIBAI QUBAN YE, it is characterized in that: (1) at first is the extracting method of plant water-soluble extract: with parts by weight: the Radix Angelicae Dahuricae 5～15, Radix Glycyrrhizae 5-25, Radix Ginseng 5-15, Cortex Mori 5-20, Folium Vaccinii vitis-idaeae 10-35, Rhizoma Chuanxiong 10-25, Radix Saposhnikoviae 5-30, flower of mustard 5-35, Aloe 10-30, Radix Salviae Miltiorrhizae 5-25, Radix Scutellariae 10-40, Cortex Pini 8-25, Radix Angelicae Sinensis 5-25, Ganoderma 5-20, Semen Ginkgo 10-30, Semen Ginkgo 5-20, Fructus Gardeniae 5-25, Radix Polygoni Multiflori 5-15, Radix Puerariae 5-15, Fructus Schisandrae Chinensis 5-20, Rhizoma Gastrodiae 5-15, Olibanum 5-18, Rhizoma Coptidis 5-15, Radix Codonopsis 8-20 is soaked in the ethanol of 55%-65% with 1: 5 to 1: 7 ratio, soak time is 25～35 days, decoct then, change slow fire into after elder generation's intense fire boiling, can hang that palm ie in solution drop can be attached to a planar object surface and stop when not dripping when decocting the solution that is concentrated in the pot, cooled and filtered, the filtrate of collecting gained is the plant water-soluble extract, and its effective ingredient concentration is more than 80%; (2) with parts by weight be: plant water-soluble extract 10-25, kojic acid 1-5, vitamin A 1-5, caffeic acid 1-5, L-vitamin C 0.5-5, ferulic acid 0.5-5, vitamin B3 0.5-5, propylene glycol 1-10, hyaluronic acid 0.05-0.5, trimethyl glycine 1-10, water solublity ceramide 0.5-5 add among the deionized water 40-60 successively while stirring, restir 10-20 minute afterwards; (3) adding Methyl p-hydroxybenzoate 0.2-0.6, Tween-40 0.2-0.8 stirs; (4) ultraviolet disinfection 40-60 minute, filter, leave standstill and got product in 20-24 hour.
4, the manufacture method of FUHE MEIBAI QUBAN YE as claimed in claim 3 is characterized in that: concentration of ethanol is 60% in the extracting method of the middle plant water-soluble extract of described step (1).
5, profit requires the manufacture method of 3 or 4 described FUHE MEIBAI QUBAN YE, it is characterized in that: plant water-soluble extract raw material and alcoholic acid ratio are 1: 6 in the described step (1).
6, the manufacture method of the described FUHE MEIBAI QUBAN YE of claim 5 is characterized in that: the soak time of plant water-soluble extract raw material is 30 days in the described step (1).
7, the manufacture method of the described FUHE MEIBAI QUBAN YE of claim 5 is characterized in that: its raw materials in part by weight is: plant water-soluble extract 20, kojic acid 2, vitamin A 3, caffeic acid 2, L-vitamin C 3, ferulic acid 3, vitamin B3 2, propylene glycol 6, hyaluronic acid 0.2, trimethyl glycine 5, water solublity ceramide 2, Methyl p-hydroxybenzoate 0.4, Tween-40 0.6, deionized water 50; Wherein, described plant water-soluble extract raw material weight umber is: the Radix Angelicae Dahuricae 10, Radix Glycyrrhizae 20, Radix Ginseng 8, Cortex Mori 15, Folium Vaccinii vitis-idaeae 22, Rhizoma Chuanxiong 18, Radix Saposhnikoviae 24, flower of mustard 20, Aloe 23, Radix Salviae Miltiorrhizae 18, Radix Scutellariae 25, Cortex Pini 15, Radix Angelicae Sinensis 16, Ganoderma 15, Semen Ginkgo 20, Semen Ginkgo 16, Fructus Gardeniae 20, Radix Polygoni Multiflori 10, Radix Puerariae 11, Fructus Schisandrae Chinensis 15, Rhizoma Gastrodiae 8, Olibanum 14, Rhizoma Coptidis 10, Radix Codonopsis 15.
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