CN108836905A - The moisturizing maintenance composition for stimulating cell aquaporin to generate - Google Patents
The moisturizing maintenance composition for stimulating cell aquaporin to generate Download PDFInfo
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- CN108836905A CN108836905A CN201810763542.2A CN201810763542A CN108836905A CN 108836905 A CN108836905 A CN 108836905A CN 201810763542 A CN201810763542 A CN 201810763542A CN 108836905 A CN108836905 A CN 108836905A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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Abstract
The present invention discloses a kind of moisturizing maintenance composition that stimulation cell aquaporin generates, the active component of the moisturizing maintenance composition is by hydrolyzing heartsease extract, Sodium Hyaluronate, biological carbohydrate gum -1, Cer NP and -1 copper of tripeptides composition, the present invention also provides application of the moisturizing maintenance composition in the cosmetics that preparation has moisturizing maintenance effect and the cosmetics comprising the moisturizing maintenance composition, the synergistic function that the present invention passes through each active component, effective stimulus cell aquaporin generates, reach moisturizing, splendid effect of maintenance skin barrier.
Description
Technical field
The invention belongs to cosmetic product technical fields, and in particular to a kind of moisturizing that stimulation cell aquaporin generates
Maintenance composition.
Background technique
The aging of skin is related with moisture content of skin, the hydratability of cuticula and barrier function.Aquaporin (AQP)
It is the integral membrane protein of a kind of energy rapid transport water of the discovery nineties in last century.Have now been found that AQP has 13 in mammals
A hypotype, the distribution of different AQP hypotypes have tissue, cell, subcellular specificity.The aquaporin being mainly distributed on skin
It is AQP3, it belongs to water-glycerol channel protein subfamily.Have now been found that AQP3 participates in a variety of physiology, pathologic process, it and urine
Concentration, the fluid balance of airway surface, the absorption of enteron aisle water have substantial connection.And in the pathophysiological process of skin,
AQP3 can equally transport water, glycerol reaches epidermis, therefore the barrier action of epidermis, the preservation of water are made great sense.
There is researcher's discovery, the missing of mammal skin AQP3 can lead to dry skin, the decline of cuticula aquation, skin elasticity
Decline, skin barrier reparation delay, biological synthetic functional is impaired and wound healing postpones.Therefore we are it is necessary to go to develop
It is a that aquaporin 3 (AQP3) is stimulated to generate, while the product of moisturizing maintenance skin, it is protected as our most basic skins
Reason.
Summary of the invention
It is an object of the present invention to provide a kind of moisturizing maintenance compositions that stimulation cell aquaporin generates, should
Moisturizing maintenance composition passes through the generation of stimulation cell aquaporin first, increases the moisture circulation of epidermis, while enhancing table
The ability that skin retains moisture keeps skin wet, cuticula angling normal to reduce trans epidermal water loss, then effective by addition
Maintenance ingredient, to reach moisturizing, maintenance, the effect of restoring epidermal barrier.
It is another object of the present invention to provide the moisturizing maintenance compositions to have moisturizing maintenance effect in preparation
Cosmetics in application.
It is yet a further object of the present invention to provide the cosmetics comprising the moisturizing maintenance composition.
Above-mentioned purpose of the invention is achieved through the following technical solutions：
A kind of moisturizing maintenance composition that stimulation cell aquaporin generates, which is characterized in that moisturizing maintenance combination
The active component of object is made of hydrolysis heartsease extract, Sodium Hyaluronate, biological carbohydrate gum -1, Cer NP and -1 copper of tripeptides.
The present invention improves human skin moisturizing maintenance effect by two necessary factors：1, the moisture circulation (benefit of epidermis
With natural botanical extraction liquid hydrolysis heartsease extract stimulation moisture of skin channel synthesis), 2, epidermis retain moisture ability
(passing through interior promotion, outer supplement hyaluronic acid).Pass through moisturizing maintenance ingredients Biogenic carbohydrate gum -1, Cer NP and tripeptides -1 simultaneously
The synergistic effect of copper, to reach safe and effective moisturizing maintenance effect.
The moisturizing maintenance composition, the component containing following mass percentage：
Surplus is one or more of common matrix, deionized water, purified water and the distilled water of cosmetics exterior-applied formulation.
Preferably, the moisturizing maintenance composition, the component containing following mass percentage：
Surplus is one or more of common matrix, deionized water, purified water and the distilled water of cosmetics exterior-applied formulation.
In the present invention, the hydrolysis heartsease extract, Sodium Hyaluronate, biological carbohydrate gum -1, Cer NP and tripeptides -1
Copper can be commercial product, can also voluntarily prepare according to the record of the prior art, each extract should meet related quality criterion requirement.
What the common matrix of the cosmetics exterior-applied formulation was known to the skilled person can be applied to the normal of cosmetics
It is cosmetically acceptable, it is preferable that the common matrix of cosmetics exterior-applied formulation includes emulsifier, grease, moisturizing with matrix
One of agent, moisturizer, thickener, polyalcohol, preservative, chelating agent, essence are a variety of.
As a preferred embodiment of the present invention, the hydrolysis heartsease extract is that commercially available hydrolysis heartsease mentions
Object is taken, it is furthermore preferred that its solid content is preferably 28~42g/L；
Hydrolysis heartsease extract in the present invention is a kind of active constituent that oligosaccharides is rich in from wild heartsease, Latin
Name is VIOLA TRICOLOR, it plays regulatory function stable in Stratum Corneum moisture by two kinds of adjustment mechanisms：1, it flows
It is logical：By stimulating the moisture being embedded in cell membrane lipids circulation --- the synthesis of aquaporin -3 is arrived to improve corium
The water of epidermis recycles.2, it is resident：By promoting supplementary table skin hyaluronic acid and receptor protein CD44 (to be present in keratinocyte
A kind of transmembrane glycoprotein on surface is important receptor of the hyaluronic acid on keratinocyte surface, can be fixed in thin
In extracellular matrix, play biological effect) synthesis, to improve the binding ability of transepidermal water.Therefore hydrolysis heartsease is extracted
Object can play the potent moisturizing to epidermis.
As a preferred embodiment of the present invention, the Sodium Hyaluronate is the pure powder of commercial clear matter acid sodium
End, is a kind of Sodium Hyaluronate of wide range, and molecular weight is 50~3000KDa, content >=93%.
Sodium Hyaluronate is the sodium salt of hyaluronic acid, is the Sodium Hyaluronate of an intact molecular weight width, therefore it is not
Be the effect of focusing on a certain specified molecular weight but pay close attention to intact molecular weight width mutual synergistic effect, such as our human bodies
Natural hyaluronic acid is the same, more efficient, safer, and having specific cytology process when acting on skin, (stable state stress
State).Because hyaluronic acid with the Specific Interactions of their cell receptor CD44 shows a kind of rule, this rule makes skin
Obtaining cell has the ability of " perception " microenvironment and responds environmental stimuli by signal transduction or cytoskeleton dynamic regulation.
Carboxyl, the hydroxyl contained in hyaluronan molecule, makes that it forms intramolecular in aqueous solution and intermolecular hydrogen bonding is same
When also there is spiral shape space conformation, this chemical structure makes it have very strong water imbibition, hyaluronic acid can retain than from
Body weighs 500~1 000 times of moisture.Hyaluronic acid (HA) is a kind of mucopolysaccharide, can find in dermal cell interstitial, play and tie up
Determine the effect of moisture and electrolysis regulation.Also it is metabolic to promote keratinocyte (KC), and in cell exocrine, can promote
Spread water and nutrient.Hyaluronic acid (HA) does not fill merely space, while also anchored receptor PROTEIN C D44 (cell adherence point
Son).Hyaluronic acid (HA) participates in keratinocyte (KC) proliferation and differentiation, and in basal layer, hyaluronic acid activation cutin is formed
The formation of cell (KC) and laminated body.The reciprocation of HA-CD44 promotes the lifelong constant regeneration of keratinocyte, from column
When shape basal cell division, and terminate in horn cell flattening.Hyaluronic acid (HA) is a crucial water relevant molecule, with
The waterproof barrier of skin is related.
As a preferred embodiment of the present invention, the biological carbohydrate gum -1 is commercially available biological carbohydrate gum -1
1.1% linear poly- polysaccharide solution, is macromolecule (106Dalton) polysaccharide viscosity solution.
Biological carbohydrate gum -1, a kind of natural polymer are obtained by bacterial fermentation with soybean by corn, are possessed solely
Special structure, the monosaccharide structure rich in L-fucose, D- galactolipin and galacturonic acid.With moisturizing film forming, moistening effect
It is slowly increased, reaches its maximum value after 3 hours, formed with the hyaluronic acid for reaching moisturizing maximum value after 1 hour complementary, prolong
The time of long moisturizing.It can promote the differentiation of horn cell, promote the expression of loricrin, involurin, therefore have recombination skin
The function of barrier.There are fucose receptors on horn cell surface, and the fucose of -1 richness 33% of biological carbohydrate gum, containing therefore biology
Carbohydrate gum can be effectively fixed on cell receptor, therefore it can participate in intercellular communication and synergistic effect, it is possible to be risen
To the effect of inflammation courier's remover, reaches and alleviate inflammation, anaphylactoid effect.
As a preferred embodiment of the present invention, the Cer NP is commercially available ceramide content
47% powder is a kind of water dispersible ceramide powder based on brand-new solid lipid separation decomposition technique.
The ingredient is the natural ceramide generated by yeast fermentation, safe and efficient, is the ingredient of skin lipid, with
Skin has high-affinity.Ceramide is necessary constituent in healthy skin cuticula, high in the content of intercellular lipid
It up to 40-50%, is filled between cell in gap, plays adhesive effect, prevent in skin moisture content from appearing, and it is superfluous different
Object, which can not penetrate into, to be come, and has barrier protection function.Leading role is played in skin barrier function regulation, is a kind of and holding
Skin is delicate, soft has significant relationship substance.Skin barrier function is maintained, the adhesion strength between keratinocyte can be remarkably reinforced,
The degree of drying for improving skin, reduces the furfur phenomenon of skin.
Ceramide has hydrone ability of associating by force very much, it passes through forms reticular structure maintenance skin water in cuticula
Point.Therefore, ceramide, which has, prevents moisture of skin loss effect.Contain a large amount of hydrophilic radicals in ceramide structure, it is right
Water has preferable affinity interaction.Ceramide can promote epidermis aquation, promote epidermal cell cohesiveness, prevent dry skin de-
Bits, keep skin smooth flexible；Bed board double-layer structure can be formed in horn cell, and transepidermal water is effectively prevent to distribute；It can seep
Thoroughly to epidermis depths, dry skin is promoted to regain to water holding capacity, there is prominent moistening effect.
As a preferred embodiment of the present invention, -1 copper of tripeptides is peptide purity>98% blue is to purple
Color powder.
- 1 copper of tripeptides is commercial product, is by linking copper ion and GHK (tripeptides Gly-L-His-L-Lys).
The activity of a variety of enzymes is all closely bound up with copper ion during skin wound healing, matrix update reparation, radicals scavenging etc..Copper
Ion can not individually penetrate skin barrier, by copper peptide made of linking with GHK, copper can be imported to skin, perfection plays base
Skin-active effect.For GHK in addition to having effects that deliver copper ion, itself or a kind of signal peptide can stimulate fibroblast raw
At collagen and mucopolysaccharide.Mucopolysaccharide is one of main matrix ingredient of application on human skin corium, and the hydrophily of mucopolysaccharide is extremely strong, right
Keep skin in moisture be of great significance, so its physiological function first is that moisture is made to enter space between cells, and and protein
In conjunction with and form protein gel, cell is sticked together, the effect of the cell metabolism brought into normal play plays keeping cell moisture, protects
Protect the effects of cell is not by the infringement of pathogen.Therefore -1 copper of tripeptides, which has, inhibits inflammation, reduces extracellular matrix (ECM) damage
The effect of mistake promotes ECM to generate, anti-oxidant, and skin self-regeneration is promoted to update.
On the other hand, the present invention also provides the moisturizing maintenance compositions has the makeup of moisturizing maintenance effect in preparation
Application in product.
The present invention also provides a kind of cosmetics, include the moisturizing maintenance composition.
The dosage form of the cosmetics is cream shape, emulsion form, gel or aqua shape.
Moisturizing maintenance composition of the invention can be directly applied to skin surface, can also be further used for producing cosmetics
It is applied to skin surface again.
In the cosmetics of the dosage forms such as production preparation cream shape, emulsion form, gel or aqua shape, other in cosmetics
Component can be carried out according to the routine operation of this field, and moisturizing remediation composition of the invention is added to cosmetics in production
In.
The present invention has the following advantages that：The present invention, which contains, can stimulate the synthesis of aquaporin -3, promote epidermis hyaluronic acid
The hydrolysis heartsease extract of synthesis, Sodium Hyaluronate related with the waterproof barrier of skin have releiving for recombination skin barrier
The biological carbohydrate gum -1 of function, maintenance skin barrier function, the Cer NP for improving dry skin inhibit inflammation, promote skin certainly
- 1 copper of tripeptides of my restoration updating reaches the generation of stimulation cell aquaporin, moisturizing by five kinds of active constituent synergistic effects
The effect of maintenance skin barrier.
Detailed description of the invention
Fig. 1 is microgroove caused by 7 pairs of dryings of embodiment and that plays bits smooth action diagram.
Specific embodiment
Below in conjunction with specific embodiment, present invention is further described in detail, but embodiments of the present invention are not limited to
This.
A kind of moisturizing maintenance composition that stimulation cell aquaporin generates disclosed by the invention, moisturizing maintenance combination
The active component of object is made of hydrolysis heartsease extract, Sodium Hyaluronate, biological carbohydrate gum -1, Cer NP and -1 copper of tripeptides.
By the synergistic function of each active component, effective stimulus cell aquaporin is generated, and reaches high moisturizing, maintenance skin screen
Splendid effect of barrier.
In the present invention, hydrolysis heartsease extract, Sodium Hyaluronate, biological carbohydrate gum -1, Cer NP and -1 copper of tripeptides can
For commercial product, can also voluntarily be prepared according to the record of the prior art, each extract should meet related quality criterion requirement.
A kind of moisturizing maintenance composition, component and its mass percentage are：
A kind of moisturizing maintenance composition, component and its mass percentage are：
Moisturizing maintenance composition of the invention can be directly applied to skin surface, can also be further used for producing cosmetics
It is applied to skin surface again.
Embodiment 1
Moisturizing maintenance frost：
The component and its mass percentage for forming above-mentioned moisturizing maintenance frost be：
Oily phase：
Water phase：
Low temperature addition (45 DEG C) after emulsification：
After oily phase, water phase are heated separately to 78 DEG C, two-phase mixtures homogeneous 10 minutes, stirring cooling cooled to 45 DEG C and adds
Enter to hydrolyze heartsease extract, biological carbohydrate gum -1, -1 copper of 10% Cer NP aqueous solution and tripeptides, preservative (this field routine
Use preservative), essence (essence commonly used in the art), stir evenly, 35 DEG C place after at white fine and smooth uniform lotion.
Hydrolyzing heartsease extract is commercially available France Qian Laibo (SILAB) companyHydrolysis
The solid content of heartsease extract is 28~42g/L, is herein only to enumerate, and is not restriction.
Sodium Hyaluronate is commercially available Italy ROELMI HCP S.r.l'sA kind of Sodium Hyaluronate of wide range
Powder, molecular weight are 50~3000KDa, and content >=93% is only to enumerate herein, are not restriction.Biological carbohydrate gum -1 is commercially available
French element Lai Biya (SOLABIA) companyFor the linear poly- polysaccharide of biological carbohydrate gum -1 1.1%
Aqueous solution is only to enumerate herein, is not restriction.
Cer NP is the DS-HydroCeramide 50 of commercially available South Korea Dou Shan (DOOSAN) company, is contained for ceramide
The powder of amount 47% is only to enumerate herein, is not restriction.
- 1 copper of tripeptides is that fine jade (WINKEY) company is tieed up in commercially available ShenzhenCopper peptide is peptide
Purity>98% blue is soluble easily in water to purple powder, is herein only to enumerate, and is not to limit.
Embodiment 2
Moisturizing maintenance cream：
The component and its mass percentage for forming above-mentioned moisturizing maintenance cream be：
Oily phase：
Water phase：
Low temperature addition (45 DEG C) after emulsification：
After oily phase, water phase are heated separately to 78 DEG C, several minutes of two-phase mixtures homogeneous, stirring cooling cools to 45 DEG C and adds
Enter to hydrolyze heartsease extract, biological carbohydrate gum -1, -1 copper of 10% Cer NP aqueous solution and tripeptides, preservative, essence, stirring
Uniformly, at white fine and smooth uniform lotion after 35 DEG C of placements.
Embodiment 3
Moisturizing maintenance gel
The component and its mass percentage for forming above-mentioned moisturizing maintenance gel be：
The preparation method of above-mentioned moisturizing maintenance gel, includes the following steps：
(1) after Stabylen 30 and PNC400, deionized water being mixed and heated to 75 DEG C, homogeneous is made it dissolve, and obtains uniformly
Gel-type vehicle；
(2) butanediol and Sodium Hyaluronate dispersion is equal, it is added in gel-type vehicle, is dispersed with stirring uniformly while stirring；
(3) stirring cooling, cool to 45 DEG C will hydrolysis heartsease extract, biological carbohydrate gum -1,1% Cer NP it is water-soluble
- 1 copper of liquid and tripeptides, preservative and gel-type vehicle are mixed evenly, and deionized water adds to full dose；
(5) above-mentioned gel is tested, after qualified, then is carried out filling up to moisturizing maintenance gel.
Embodiment 4
Moisturizing maintenance water
The component and its relative content for forming above-mentioned moisturizing maintenance water be：
The preparation method of above-mentioned moisturizing maintenance aquatic products, includes the following steps：
(1) butanediol and Sodium Hyaluronate dispersion is equal, it is added in 75 DEG C of water, is dispersed with stirring uniformly while stirring.
(2) stirring cooling, cool to 45 DEG C will hydrolysis heartsease extract, biological carbohydrate gum -1,1% Cer NP it is water-soluble
- 1 copper of liquid and tripeptides, preservative addition stir evenly, and deionized water adds to full dose；
(3) above-mentioned toner is tested, after qualified, then is carried out filling up to moisturizing maintenance water.
Embodiment 5
Moisturizing maintenance essence
The component and its relative content for forming above-mentioned moisturizing maintenance be：
The preparation method of above-mentioned moisturizing maintenance essence product, includes the following steps：
(1) butanediol and xanthan gum, Sodium Hyaluronate dispersion is equal, it is added in 75 DEG C of water, is dispersed with stirring while stirring
Uniformly.
(2) stirring cooling, cool to 45 DEG C will hydrolysis heartsease extract, biological carbohydrate gum -1,1% Cer NP it is water-soluble
- 1 copper of liquid and tripeptides, preservative addition stir evenly, and deionized water adds to full dose；
(3) above-mentioned essence is tested, after qualified, then is carried out filling up to moisturizing maintenance essence skincare product.
Embodiment 6
Moisturizing maintenance essence
The component and its relative content for forming above-mentioned moisturizing maintenance essence be：
The preparation method of above-mentioned moisturizing maintenance essence product, includes the following steps：
(1) butanediol and xanthan gum, Sodium Hyaluronate dispersion is equal, it is added in 75 DEG C of water, is dispersed with stirring while stirring
Uniformly.
(2) stirring cooling, cool to 45 DEG C will hydrolysis heartsease extract, biological carbohydrate gum -1,1% Cer NP it is water-soluble
- 1 copper of liquid and tripeptides, preservative addition stir evenly, and deionized water adds to full dose；
(3) above-mentioned essence is tested, after qualified, then is carried out filling up to moisturizing maintenance essence skincare product.
Embodiment 7
Observation on probation
Observation of curative effect is carried out using moisturizing maintenance cosmetics prepared by the present invention and control sample
Sample：Embodiment 5
Control sample：By heartsease extract, Sodium Hyaluronate, the biological carbohydrate gum -1, Cer NP and three in embodiment 5
- 1 copper of peptide removes.
One, in vitro test
1, to the influence of synthesis aquaporin -3 (AQP3)
Human keratinous cell culture medium is carried out immunoblotting (basic principle be cell after being separated by electrophoresis or
Histone is transferred on solid support from gel, is then coloured with specific antibody to corresponding antigens, is then passed through
Protein expression situation is reflected with color depth in the position for analyzing coloring) research, cosmetics of the present invention and control sample are compared,
The synthesis of stimulation aquaporin -3 reaches 45%, so as to improve the water circulation from corium to cuticula.
2, to the influence of synthesis hyaluronic acid
The analysis of hyaluronic acid synthesis：It is good for the specific of hop protein with HA according to HA to be bonded, with improved ELISA method, (enzyme is marked
Immmunosorbent assay) it conducts a research to human keratinous cell.Cosmetics of the present invention and control sample are compared, upper layer is significantly improved
The content of hyaluronic acid is up to 23% in culture.
Two, human trial
1, moisture retention is tested：
1. skin moisture content value (MMV)
30 people of volunteer, respectively in right-hand man's inner forearm label 4 × 4cm2 test area, same arm while label 2
A region, it is interregional every 2cm.The measurement of tested region and control zone, Mei Gequ are carried out using skin moisture content tester
Domain is measured in parallel 3 times.The blank value of each test zone is first measured, 2.0 ± 0.1mg sample/cm2 dosage is then pressed, uses cream
Sample is spread evenly across in trial zone by rubber finger cot.It smears 24 hours, 28 days and measures tested region and blank control region respectively
Moisture content value.
Human detection result shows：
After cosmetics of the present invention and control sample 24 hours, keratoderma moisture content test result shows this hair
Bright cosmetics and control sample comparison skin moisture basis content improve 9%, and 88% volunteer observed this effect.Make
With cosmetics of the present invention with control sample 4 weeks after, keratoderma moisture content test result show cosmetics of the present invention with compare
Sample compares skin moisture basis content and improves 13%, and 60% volunteer observed this effect.
2. scattering and disappearing through transepidermal water is worth (TEWL)
TEWL value is an important symbol of skin barrier quality, and the TEWL value of skin is lower, illustrates the barrier function of skin
Can be better, conversely, then poorer.
30 people of volunteer, respectively in right-hand man's inner forearm label 4 × 4cm2 test area, same arm while label 2
A region, it is interregional every 2cm.The measurement of tested region and control zone, Mei Gequ are carried out using the moisture of skin analyzer that scatters and disappears
Domain is measured in parallel 3 times.The blank value of each test zone is first measured, 2.0 ± 0.1mg sample/cm2 dosage is then pressed, uses cream
Sample is spread evenly across in trial zone by rubber finger cot.It smears 24 hours, 28 days and measures tested region and blank control region respectively
TEWL value.
Human detection result shows：
Using cosmetics of the present invention with control sample 24 hours after, TEWL value test result show cosmetics of the present invention with it is right
Comparison TEWL value reduces 8.4% in the same old way.After cosmetics of the present invention and control sample 4 weeks, TEWL value test result shows this
Invention cosmetics and control sample comparison TEWL value reduce 13.4%, and 60% volunteer observed this effect.
2, it is disturbed and is itched due to caused by dry skin
30 people of volunteer uses cosmetics of the present invention and control sample respectively, and after continuous use 28 days, 65% volunteer is bright
It is aobvious to feel skin moisture-keeping, it itches and demonstrate,proves shape and considerably reduce.
3, it is smoothed to what microgroove caused by dry and serving was considered to be worth doing
The volunteer for choosing 30 self-report dry skin uses cosmetics of the present invention in inner forearm, passes through 50 times
Imaging system is respectively before use, using skin image data is acquired after 28 days, and visual evaluation cosmetics of the present invention are to dry flesh
Skin long-time service can effectively smooth microgroove and play bits, persistently support profit, full effect.
It is any ripe although the present invention is disclosed as above with embodiment, its protection scope being not intended to limit the invention
Those skilled in the art are known, in made change and retouching without departing from the spirit and scope of the invention, should belong to this hair
Bright protection scope.
Claims (7)
1. a kind of moisturizing maintenance composition that stimulation cell aquaporin generates, which is characterized in that the moisturizing maintenance composition
Active component be made of hydrolysis heartsease extract, Sodium Hyaluronate, biological carbohydrate gum -1, Cer NP and -1 copper of tripeptides.
2. the moisturizing maintenance composition that stimulation cell aquaporin according to claim 1 generates, which is characterized in that contain
There is the component of following mass percentage：
Surplus is one or more of common matrix, deionized water, purified water and the distilled water of cosmetics exterior-applied formulation.
3. the moisturizing maintenance composition that stimulation cell aquaporin according to claim 1 generates, which is characterized in that contain
There is the component of following mass percentage：
Surplus is one or more of common matrix, deionized water, purified water and the distilled water of cosmetics exterior-applied formulation.
4. according to claim 1 to described in 3 any one stimulation cell aquaporin generate moisturizing maintenance composition,
It is characterized in that,
The solid content of the hydrolysis heartsease extract is 28~42g/L；
The Sodium Hyaluronate molecular weight is 50~3000KDa；
The linear poly- polysaccharide solution that the biological carbohydrate gum -1 is 1.1%, average molecular weight 106Dalton；
The peptide purity of -1 copper of tripeptides>98%.
5. the cosmetics that moisturizing maintenance composition described in claims 1 to 3 any one has moisturizing maintenance effect in preparation
In application.
6. a kind of cosmetics include moisturizing maintenance composition described in claims 1 to 3 any one.
7. cosmetics according to claim 6, which is characterized in that the dosage form of the cosmetics is cream shape, emulsion form, coagulates
Gluey or aqua shape.
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| CN201810763542.2A CN108836905A (en) | 2018-07-11 | 2018-07-11 | The moisturizing maintenance composition for stimulating cell aquaporin to generate |
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Cited By (8)
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| CN111214418A (en) * | 2020-03-13 | 2020-06-02 | 佛山市奥姿美生物科技有限公司 | Efficient barrier repair composition and application thereof |
| CN111358748A (en) * | 2020-05-18 | 2020-07-03 | 邓光浩 | Mask essence containing date palm seed extract and preparation method thereof |
| CN111514085A (en) * | 2020-05-18 | 2020-08-11 | 邓光浩 | Moisturizing composition containing date seed extract and mask |
| CN113244142A (en) * | 2021-05-21 | 2021-08-13 | 二元(苏州)工业科技有限公司 | Water-oil superconducting osmotic compound and preparation method and application thereof |
| CN114366708A (en) * | 2021-12-21 | 2022-04-19 | 深圳市美瑞健康科技有限公司 | Mask for repairing barrier after photoelectric operation and preparation method thereof |
| CN115501134A (en) * | 2022-09-27 | 2022-12-23 | 华熙生物科技股份有限公司 | Cosmetic composition containing copper-blue peptide |
| CN115517997A (en) * | 2022-09-27 | 2022-12-27 | 浙江湃肽生物股份有限公司 | Cosmetic composition and preparation method and application thereof |
| CN115947666A (en) * | 2023-02-02 | 2023-04-11 | 深圳市迪克曼生物科技有限公司 | Rice bran oil ceramide and synthesis method and application thereof |
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| CN111514085A (en) * | 2020-05-18 | 2020-08-11 | 邓光浩 | Moisturizing composition containing date seed extract and mask |
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| CN111514085B (en) * | 2020-05-18 | 2021-05-11 | 高宝化妆品（中国）有限公司 | Moisturizing composition containing date seed extract and mask |
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| CN115501134A (en) * | 2022-09-27 | 2022-12-23 | 华熙生物科技股份有限公司 | Cosmetic composition containing copper-blue peptide |
| CN115517997A (en) * | 2022-09-27 | 2022-12-27 | 浙江湃肽生物股份有限公司 | Cosmetic composition and preparation method and application thereof |
| CN115517997B (en) * | 2022-09-27 | 2024-01-23 | 浙江湃肽生物股份有限公司 | Cosmetic composition, and preparation method and application thereof |
| CN115947666A (en) * | 2023-02-02 | 2023-04-11 | 深圳市迪克曼生物科技有限公司 | Rice bran oil ceramide and synthesis method and application thereof |
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