CN113244142A - Water-oil superconducting osmotic compound and preparation method and application thereof - Google Patents
Water-oil superconducting osmotic compound and preparation method and application thereof Download PDFInfo
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- CN113244142A CN113244142A CN202110556056.5A CN202110556056A CN113244142A CN 113244142 A CN113244142 A CN 113244142A CN 202110556056 A CN202110556056 A CN 202110556056A CN 113244142 A CN113244142 A CN 113244142A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/31—Hydrocarbons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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Abstract
The invention discloses a water-oil superconducting osmotic compound, and a preparation method and application thereof, wherein the compound comprises 45-50% of an efficacy component A and 50-55% of an efficacy component B in percentage by mass; the functional component A is a mixture of hydrolyzed pansy extract, water, 1, 2-ethylene glycol and caprylyl glycol, wherein the water, the 1, 2-ethylene glycol and the caprylyl glycol are all used as solvents, and the adding amount of the hydrolyzed pansy extract in the functional component A is 0.01-10% by mass percent; the functional component B is a mixture of fullerene and squalane, and the addition amount of the fullerene in the functional component B is recorded as 0.01-5% by mass percent. The invention utilizes the powerful fat-soluble antioxidant active substance to stimulate the expression of aquaporins by using the hydrolyzed pansy extract on the premise of keeping the oil activity and high permeability, thereby realizing the high-efficiency permeation of water.
Description
Technical Field
The invention relates to a compound and a corresponding preparation method and application thereof, in particular to a water-oil superconducting osmotic compound and a preparation method and application thereof in cosmetics, belonging to the field of cosmetic application.
Background
The skin is the largest organ of human organs, covers the surface layer of the human body, directly contacts with the external environment, and undertakes the tasks of protection, excretion, body temperature regulation, external stimulation feeling and the like, so that the skin care and protection are the key points of attention of many people, particularly women. Therefore, various skin care products and cosmetics with different types and functions are in the market at present, so as to meet the purchase demands of the majority of female consumers.
On the premise of not considering microorganisms, the outermost layer of the skin is a sebum membrane and a cuticle, and when the cosmetics are used, the cosmetics can effectively play the skin care function with the highest efficiency only after penetrating through the sebum membrane and the cuticle. The sebaceous membrane is mainly composed of lipids; the stratum corneum is mainly composed of keratinocytes and intercellular lipids, and has a structure similar to a brick wall, wherein the brick is the keratinocytes, and the wall is the intercellular lipids. Oil components in cosmetics are absorbed by the skin mainly through intercellular lipids, water in cosmetics is absorbed by the skin through keratinocytes, and water is absorbed at a relatively low efficiency through the keratinocytes.
At present, the market share of water-containing cosmetics (pure water type, O/W, W/O) in the cosmetic market is about 98% or more, and due to the aforementioned barrier effect of keratinocytes on moisture, the moisture in such cosmetics is likely not to be able to penetrate into the skin, and the effective components thereof cannot really and efficiently exert their intended effects.
In summary, how to provide a brand-new superconducting penetrant compound based on the prior art, and achieve high-efficiency penetration of moisture and synergistically improve the permeability of cosmetics on the premise of optimizing oil penetration, is a problem to be solved by those skilled in the art.
Disclosure of Invention
In view of the above-mentioned drawbacks of the prior art, the present invention provides a water-oil superconductive permeable compound, a method for preparing the same, and a cosmetic application thereof, specifically as follows.
The water-oil superconducting penetrating compound comprises the following components in percentage by mass: 45% -50% of an efficacy component A and 50% -55% of an efficacy component B;
the functional component A is a mixture of hydrolyzed pansy extract, water, 1, 2-ethylene glycol and caprylyl glycol, wherein the water, the 1, 2-ethylene glycol and the caprylyl glycol are all used as solvents, and the adding amount of the hydrolyzed pansy extract in the functional component A is 0.01-10% by mass percent;
the functional component B is a mixture of fullerene and squalane, and the addition amount of the fullerene in the functional component B is recorded as 0.01-5% by mass percent.
Preferably, the hydrolyzed pansy extract contains an efficacy active factor, and the efficacy active factor is pansy oligosaccharide.
A method for preparing an oil-in-water superconducting osmotic compound, for preparing an oil-in-water superconducting osmotic compound as described above, comprising the steps of:
s1, taking a certain amount of raw materials, stirring and mixing to obtain an effect component A and an effect component B respectively;
s2, starting a material mixing reaction kettle, adding the effect component A and the effect component B into the material mixing reaction kettle, heating to 35-55 ℃, stirring at a speed of 15-30 r/min, and mixing for 5-15 min;
s3, closing the mixing reaction kettle, and after the temperature in the mixing reaction kettle is reduced to 30-40 ℃, carrying out blanking operation on the compound in the mixing reaction kettle to obtain the water-oil superconducting permeable compound.
Preferably, in the step S2, the heating temperature is 40 ℃, the stirring speed is 20r/min, and the mixing and stirring time is 10 min.
Preferably, in the step S3, after the temperature in the mixing reaction kettle is reduced to 35 ℃, the compound in the mixing reaction kettle is subjected to a blanking operation.
The application of the water-oil superconducting osmotic compound is to add the water-oil superconducting osmotic compound into an O/W type cosmetic, wherein the O/W type cosmetic comprises 0.1-20% of an effect component A and 0.01-10% of an effect component B in percentage by mass.
Preferably, the O/W type cosmetic comprises 4% of the efficacy component A and 1% of the efficacy component B in percentage by mass.
Compared with the prior art, the invention has the advantages that:
the superconducting osmotic compound provided by the invention utilizes a powerful fat-soluble antioxidant active substance, and stimulates the expression of aquaporins by using a hydrolyzed pansy extract on the premise of keeping oil activity and high permeability, so that the high-efficiency permeation of water is realized. The compound of the invention is applied to various cosmetics, can obviously improve the integral permeability of the cosmetics and improve the efficacy of the cosmetics.
In addition, the preparation method disclosed by the invention is clear in flow and simple in steps, provides convenience conditions for preparation and production of various cosmetic enterprises, and is suitable for large-scale popularization and application of the enterprises.
The following detailed description of the embodiments of the present invention is provided to facilitate understanding and understanding of the technical solutions of the present invention.
Detailed Description
The invention discloses a water-oil superconducting osmotic compound, a preparation method thereof and application thereof in cosmetics.
Aquaporins (AQPs) are a family of membrane proteins that reside primarily in the cell membrane and selectively transport water or glycerol-like water, thereby allowing increased water permeability. Numerous studies have demonstrated that aquaporins are an important part of skin hydration, directly related to the state of skin hydration. The water-oil superconducting penetrant compound of the invention can simultaneously and effectively improve the permeability of cosmetics from two dimensions of water and oil by cooperating two functional components, and the specific scheme is as follows.
The water-oil superconducting osmotic compound comprises 45-50% of an efficacy component A and 50-55% of an efficacy component B in percentage by mass.
The functional component A is a mixture of hydrolyzed pansy extract, water, 1, 2-ethylene glycol and caprylyl glycol, wherein the water, the 1, 2-ethylene glycol and the caprylyl glycol are used as solvents, and the adding amount of the hydrolyzed pansy extract in the functional component A is 10-30% by mass percent.
The hydrolyzed pansy extract contains an efficacy active factor, and the efficacy active factor is pansy oligosaccharide. The pansy oligosaccharide used as an effective active factor can greatly improve the water permeability and promote the water circulation in the skin, ensures that the water flows fully from the dermis to the horny layer, and comprehensively improves the water permeability.
The functional component B is a mixture of fullerene and squalane, and the addition amount of the fullerene in the functional component B is 20-40% by mass percent.
The two substances selected here, squalane and skin surface lipid, are similar in structure, and due to the principle of similarity and compatibility, they are more skin-friendly and more easily absorbed by the skin. Meanwhile, the added fat-soluble strong antioxidant active substance fullerene has a molecular structure of football-shaped molecules consisting of 60 carbon atoms, and the fullerene can effectively protect skin surface lipid and lipid in cosmetics from decay caused by the attack of oxidation free radicals, so that the oil permeability is comprehensively improved.
A method for preparing an oil-in-water superconducting osmotic compound, for preparing an oil-in-water superconducting osmotic compound as described above, comprising the steps of:
s1, taking a certain amount of raw materials, stirring and mixing to respectively obtain an efficacy component A and an efficacy component B.
S2, starting a material mixing reaction kettle, adding the effect component A and the effect component B into the material mixing reaction kettle, heating to 35-55 ℃, stirring at a speed of 15-30 r/min, and mixing for 5-15 min; the preferable scheme here is that the heating temperature is 40 ℃, the stirring speed is 20r/min, and the mixing and stirring time is 10 min.
S3, closing the mixing reaction kettle, and after the temperature in the mixing reaction kettle is reduced to 30-40 ℃, performing blanking operation on the compound in the mixing reaction kettle to obtain a water-oil superconducting permeable compound; the preferable scheme here is that after the temperature in the mixing reaction kettle is reduced to 35 ℃, the compound in the mixing reaction kettle is subjected to blanking operation.
The application of the water-oil superconducting osmotic compound is to add the water-oil superconducting osmotic compound into an O/W type cosmetic, wherein the O/W type cosmetic comprises 0.1-20% of an effect component A and 0.01-10% of an effect component B in percentage by mass. In the actual application process, the O/W type cosmetic preferably comprises 4% of efficacy component A and 1% of efficacy component B in percentage by mass.
In order to verify the effectiveness of the present invention, the laboratory conducted the following comparative experiment, in which the laboratory conducted the following 3 groups of control experiments with the blank group, the test personnel were 30 persons, the half face was used with the O/W type cosmetic added with the water-oil superconductive penetrating compound of the present invention and the blank group, respectively, 2 times a day in the morning and at night, and the application was continued for 28 days/half face.
In a first set of comparative experiments, cosmetics added with an effective component A (the addition amount is 0.1-20% by mass percent) are used in an experimental group, and cosmetics not added with the components are used in a blank group. As can be seen from measurement by using a Corneometer instrument, in the aspect of the instant moisturizing effect, the experimental group is averagely improved by 6% after being smeared for 4 hours, the blank group is averagely improved by 3%, and the experimental group is averagely improved by 13% after being smeared for 24 hours, and the blank group is averagely improved by 4%. In the aspect of long-acting (28-day) moisturizing effect, the average increase of the experimental group is 18%, and the average increase of the blank group is 5%. The wrinkle replicates were observed using a video camera equipped with image analysis software to determine total wrinkle length and total wrinkle count, with an average decrease in total wrinkle length test group of 14%, an average decrease in blank group of 1%, an average decrease in total wrinkle count test group of 7%, and an average decrease in blank group of 1%.
In a second set of comparative experiments, the skin care products added with the effective component B (the addition amount is 0.01-10% by mass percent) are used in the experimental group, and the skin care products not added with the components disclosed by the invention are used in the blank group. The reduction in skin moisture loss was determined using a transdermal moisture loss tester, with an average reduction of 20% in the experimental group and 2.8% in the blank group. The skin elasticity tester is used for testing the increase of the skin elasticity, the average increase of an experimental group is 11 percent, and the average increase of a blank group is 1 percent. The oxidation resistance of the skin was tested using copper ion reduction, and the oxidation resistance of the experimental group was on average 250 times higher than VC, a common antioxidant.
In a third group of comparative experiments, the skin care products added with the functional component A and the functional component B (the addition amount is 2-5% by mass percent) are used in the experimental group, and the skin care products not added with the components disclosed by the invention are used in the blank group. As can be seen from measurement by using a Corneometer instrument, in the aspect of the instant moisturizing effect, the experimental group is averagely improved by 15% and the blank group is averagely improved by 3% after being smeared for 4 hours, and the experimental group is averagely improved by 26% and the blank group is averagely improved by 4% after being smeared for 24 hours. In the aspect of long-acting (28-day) moisturizing effect, the average increase of the experimental group is 30%, and the average increase of the blank group is 5%. The wrinkle replicates were observed using a video camera equipped with image analysis software to determine total wrinkle length and total wrinkle count, with an average decrease in total wrinkle length test group of 32%, an average decrease in blank group of 1%, an average decrease in total wrinkle count test group of 25%, and an average decrease in blank group of 1%. The reduction in skin moisture loss was measured using a transdermal moisture loss tester, with an average reduction of 46% in the experimental group and 2.8% in the blank group. The skin elasticity tester is used for testing the increase of the skin elasticity, the average increase of an experimental group is 16.8 percent, and the average increase of a blank group is 1 percent. The oxidation resistance of the skin is tested by using a copper ion reduction method, and the oxidation resistance of an experimental group is averagely more than VC280 times.
In conclusion, the superconducting penetrating compound provided by the invention utilizes the powerful fat-soluble antioxidant active substances (fullerene and squalane) to stimulate the expression of aquaporins by using the hydrolyzed pansy extract on the premise of keeping the oil activity and high permeability, so that the efficient penetration of water is realized.
The compound of the invention is applied to various cosmetics, can obviously improve the integral permeability of the cosmetics and improve the efficacy of the cosmetics.
In addition, the preparation method disclosed by the invention is clear in flow and simple in steps, provides convenience conditions for preparation and production of various cosmetic enterprises, and is suitable for large-scale popularization and application of the enterprises.
It will be evident to those skilled in the art that the invention is not limited to the details of the foregoing illustrative embodiments, and that the present invention may be embodied in other specific forms without departing from the spirit or essential attributes thereof. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein.
Finally, it should be understood that although the present description refers to embodiments, not every embodiment contains only a single technical solution, and such description is for clarity only, and those skilled in the art should integrate the description, and the technical solutions in the embodiments can be appropriately combined to form other embodiments understood by those skilled in the art.
Claims (7)
1. The water-oil superconducting osmotic compound is characterized by comprising the following components in percentage by mass: 45% -50% of an efficacy component A and 50% -55% of an efficacy component B;
the functional component A is a mixture of hydrolyzed pansy extract, water, 1, 2-ethylene glycol and caprylyl glycol, wherein the water, the 1, 2-ethylene glycol and the caprylyl glycol are all used as solvents, and the adding amount of the hydrolyzed pansy extract in the functional component A is 0.01-10% by mass percent;
the functional component B is a mixture of fullerene and squalane, and the addition amount of the fullerene in the functional component B is recorded as 0.01-5% by mass percent.
2. The aqueous-oil superconducting osmotic compound of claim 1, wherein the hydrolyzed pansy extract comprises an efficacy active factor, and the efficacy active factor is pansy oligosaccharide.
3. A method for preparing a water-oil superconducting osmotic compound according to any one of claims 1 to 2, comprising the steps of:
s1, taking a certain amount of raw materials, stirring and mixing to obtain an effect component A and an effect component B respectively;
s2, starting a material mixing reaction kettle, adding the effect component A and the effect component B into the material mixing reaction kettle, heating to 35-55 ℃, stirring at a speed of 15-30 r/min, and mixing for 5-15 min;
s3, closing the mixing reaction kettle, and after the temperature in the mixing reaction kettle is reduced to 30-40 ℃, carrying out blanking operation on the compound in the mixing reaction kettle to obtain the water-oil superconducting permeable compound.
4. A method of preparing an oil-in-water superconducting osmotic compound according to claim 3, wherein: in the step S2, the heating temperature is 40 ℃, the stirring speed is 20r/min, and the mixing and stirring time is 10 min.
5. A method of preparing an oil-in-water superconducting osmotic compound according to claim 3, wherein: in the step S3, after the temperature in the mixing reaction kettle is reduced to 35 ℃, the compound in the mixing reaction kettle is subjected to a blanking operation.
6. Use of a water-oil superconducting penetrant compound according to any of claims 1-2 in an O/W cosmetic, wherein: the O/W type cosmetic comprises 0.1-20% of an efficacy component A and 0.01-10% of an efficacy component B in percentage by mass.
7. Use of an aqueous-oil superconducting penetrating compound according to claim 6, wherein: the O/W type cosmetic comprises 4% of efficacy component A and 1% of efficacy component B in percentage by mass.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202110556056.5A CN113244142A (en) | 2021-05-21 | 2021-05-21 | Water-oil superconducting osmotic compound and preparation method and application thereof |
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| CN202110556056.5A CN113244142A (en) | 2021-05-21 | 2021-05-21 | Water-oil superconducting osmotic compound and preparation method and application thereof |
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| CN113244142A true CN113244142A (en) | 2021-08-13 |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108836905A (en) * | 2018-07-11 | 2018-11-20 | 佛山市奥姿美生物科技有限公司 | The moisturizing maintenance composition for stimulating cell aquaporin to generate |
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- 2021-05-21 CN CN202110556056.5A patent/CN113244142A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108836905A (en) * | 2018-07-11 | 2018-11-20 | 佛山市奥姿美生物科技有限公司 | The moisturizing maintenance composition for stimulating cell aquaporin to generate |
Non-Patent Citations (1)
| Title |
|---|
| 广州市邦豪网络科技有限公司: ""禾真胎盘素莹润精华液"", 《国产非特殊用途化妆品备案信息服务平台》 * |
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Application publication date: 20210813 |