CN112870102A - Cosmetic composition containing glycerol glucoside and preparation method and application thereof - Google Patents
Cosmetic composition containing glycerol glucoside and preparation method and application thereof Download PDFInfo
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- CN112870102A CN112870102A CN202110373502.9A CN202110373502A CN112870102A CN 112870102 A CN112870102 A CN 112870102A CN 202110373502 A CN202110373502 A CN 202110373502A CN 112870102 A CN112870102 A CN 112870102A
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- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerol Natural products OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 title claims abstract description 162
- 229930182478 glucoside Natural products 0.000 title claims abstract description 60
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- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims abstract description 26
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Images
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4913—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
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- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Gerontology & Geriatric Medicine (AREA)
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- Cosmetics (AREA)
Abstract
The invention discloses a cosmetic composition containing glycerol glucoside and a preparation method and application thereof, wherein the cosmetic composition comprises the following components: 1 to 5 percent of glycerin, 0.05 to 2 percent of sodium pyrrolidone carboxylate, 0.05 to 0.5 percent of hyaluronic acid, 0.02 to 0.05 percent of EDTA-2Na, 0.02 to 5 percent of glycerol glucoside, 0.02 to 1 percent of D-panthenol, 0.001 to 0.25 percent of 1, 2-pentanediol, 0.02 to 2 percent of essence and the balance of water; wherein, water, glycerin, sodium pyrrolidone carboxylate, hyaluronic acid and EDTA-2Na form phase A, glyceryl glucoside, D-panthenol and 1,2 pentanediol form phase B, and essence is phase C. The cosmetic composition can not only moisturize and protect the stratum corneum from ultraviolet loss, but also provide a secondary skin effect to the skin; it also has effects in improving skin cell activity and metabolism.
Description
Technical Field
The invention belongs to the field of cosmetics, and particularly relates to a cosmetic composition containing glycerol glucoside, and a preparation method and application thereof.
Background
The information in this background section is only for enhancement of understanding of the general background of the invention and is not necessarily to be construed as an admission or any form of suggestion that this information forms the prior art that is already known to a person of ordinary skill in the art.
The dermis layer 75% of the skin is composed of collagen, and the fibrous collagen forms a net structure to provide tension and elasticity to the skin; at the same time, collagen in the dermis is also the nutrient supply site for the epidermis layer and epidermal appendages (hair), and delivers moisture to the epidermis. The important role of collagen on skin is therefore apparent, and skin growth, repair and nutrition are not well separated from collagen. The collagen can make the cells plump, so as to make the skin plump, keep the skin elastic and moist, and maintain the skin fine and smooth. Anti-wrinkle and moisturizing of skin are both associated with collagen.
The spirulina has wide application value in cosmetics. Because the spirulina contains vitamin mineral group, the spirulina can repair the skin, supplement the skin nutrition and make the skin glowing. Such as algal polysaccharides, glycerol glucosides, gamma-linolenic acid, and the like. Glycerol Glucoside (glycocide) is a glycoside compound formed by glycerol and a glucose molecule through a glycosidic bond. The glycerol glucoside can promote the synthesis of aquaporins, maintain osmotic balance, bring required moisture to skin cells, prevent inflammation, and also has obvious effects on improving skin elasticity, reducing skin redness, repairing barriers and reducing crow's feet. Glycerol glucosides have been used as cosmetic raw materials for health and beauty purposes.
The current glycerol glucoside is applied to moisturizing, anti-aging and anti-inflammatory cosmetic products, but only can achieve single effect. Therefore, the glycerol glucoside cosmetic composition can simultaneously play the roles of promoting collagen synthesis, delaying senility, reducing skin inflammation, moisturizing and the like in a short time.
Disclosure of Invention
In view of the above technical problems in the prior art, the present invention aims to provide a cosmetic composition containing glycerol glucoside, and a preparation method and applications thereof.
In order to solve the technical problems, the technical scheme of the invention is as follows:
in a first aspect, the present invention provides a cosmetic composition comprising a glycerol glucoside, consisting of:
1 to 5 percent of glycerin, 0.05 to 2 percent of sodium pyrrolidone carboxylate, 0.05 to 0.5 percent of hyaluronic acid, 0.02 to 0.05 percent of EDTA-2Na, 0.02 to 5 percent of glycerol glucoside, 0.02 to 1 percent of D-panthenol, 0.001 to 0.25 percent of 1, 2-pentanediol, 0.02 to 2 percent of essence and the balance of water;
wherein, water, glycerin, sodium pyrrolidone carboxylate, hyaluronic acid and EDTA-2Na form phase A, glyceryl glucoside, D-panthenol and 1,2 pentanediol form phase B, and essence is phase C.
In a second aspect, the present invention provides a method for preparing the glycerol glucoside-containing cosmetic composition, comprising the steps of:
mixing the components of the phase A, heating to dissolve, keeping the temperature for a set time, and cooling;
cooling the phase A solution to 20-45 ℃, adding each component of the phase B, and stirring until the mixture is uniform and free of insoluble substances;
and adding the component of the phase C into the mixed solution of the phase A and the phase B, uniformly mixing, and filtering to obtain the product.
In a third aspect, the present invention provides the use of the cosmetic composition comprising glycerol glucoside for the preparation of moisturizing water.
Compared with the prior art, the beneficial technical effects of one or more of the embodiments of the invention are as follows:
the cosmetic composition can not only preserve moisture and protect the stratum corneum from ultraviolet loss, but also help cell regeneration after exposure to the sun, prevent collagen crosslinking caused by ultraviolet, promote collagen regeneration in the skin, and provide the second skin effect for the skin; but also can reduce the production of proinflammatory cytokines and accelerate wound healing and tissue repair; improving skin cell activity and metabolism.
The composition can make skin plump, reduce wrinkle amount of skin, improve skin smoothness, and keep skin elasticity and luster; but also can improve the content of collagen in the skin, improve the effects of the loose and edema state of the skin after lipid reduction and achieve the effects of tightening and resisting wrinkles.
Drawings
The accompanying drawings, which are incorporated in and constitute a part of this application, illustrate embodiments of the application and, together with the description, serve to explain the application and are not intended to limit the application.
FIG. 1 is a graph comparing the collagen type I content of the negative control, the positive control and the formula 1 in example 1 of the present invention;
FIG. 2 is a graph comparing the improvement of fine lines on the forehead skin surface according to example 1 of the present invention;
FIG. 3 is a comparison graph of the skin moisture increase after the application of the formula 1 lotion of example 1 and the 0.5% hyaluronic acid control group is completed;
fig. 4 is a comparison graph of the loss of skin moisture after the formula 1 lotion of example 1 of the present invention and a control group of 0.5% hyaluronic acid were applied for a certain period of time.
Detailed Description
It should be noted that the following detailed description is exemplary and is intended to provide further explanation of the disclosure. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs.
It is noted that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of example embodiments according to the present application. As used herein, the singular forms "a", "an" and "the" are intended to include the plural forms as well, and it should be understood that when the terms "comprises" and/or "comprising" are used in this specification, they specify the presence of stated features, steps, operations, devices, components, and/or combinations thereof, unless the context clearly indicates otherwise.
The glycerol glucoside of the present invention is obtained by the method described in CN201811096218.6, which is a natural source and has a 2 α configuration unless otherwise specified.
In a first aspect, the present invention provides a cosmetic composition comprising a glycerol glucoside, consisting of:
1 to 5 percent of glycerin, 0.05 to 2 percent of sodium pyrrolidone carboxylate, 0.05 to 0.5 percent of hyaluronic acid, 0.02 to 0.05 percent of EDTA-2Na, 0.02 to 5 percent of glycerol glucoside, 0.02 to 1 percent of D-panthenol, 0.001 to 0.25 percent of 1, 2-pentanediol, 0.02 to 2 percent of essence and the balance of water;
wherein, water, glycerin, sodium pyrrolidone carboxylate, hyaluronic acid and EDTA-2Na form phase A, glyceryl glucoside, D-panthenol and 1,2 pentanediol form phase B, and essence is phase C.
The A-phase glycerol, the sodium pyrrolidone carboxylate, the hyaluronic acid and the EDTA-2Na have the effects:
has unique skin protecting effect, can keep skin moist and smooth, and has effects of preventing wrinkle, removing wrinkle, caring skin, promoting health and recovering skin physiological function. (skin layer)
Glycerol glucoside: has the characteristics of pure nature, high purity, high physiological activity and the like. Directly reaches the dermis layer, only has unique moisturizing performance, and also has the effects of tightening, resisting wrinkles, delaying aging, resisting inflammation, relieving allergy, growing hair, nourishing hair and the like.
D-panthenol: promoting metabolism of protein, fat and saccharide, and protecting mucosa and luster of skin surface.
1, 2-pentanediol: the antiseptic properties also enhance skin feel.
The composition can protect epidermal layer and dermal layer from steric structure. The skin can be full, and the number of skin wrinkles can be reduced, so that the smoothness of the skin is improved, and the elasticity and the smoothness of the skin are kept; but also can improve the content of collagen in the skin, improve the effects of the loose and edema state of the skin after lipid reduction and achieve the effects of tightening and resisting wrinkles.
In some embodiments, the cosmetic composition comprising glycerol glucoside consists of: 1 to 4 percent of glycerin, 0.05 to 1.5 percent of sodium pyrrolidone carboxylate, 0.05 to 0.5 percent of hyaluronic acid, 0.02 to 0.05 percent of EDTA-2Na, 0.02 to 5 percent of glycerol glucoside, 0.02 to 1 percent of D-panthenol, 0.001 to 0.25 percent of 1, 2-pentanediol, 0.02 to 2 percent of essence and the balance of water.
In some embodiments, the cosmetic composition comprising glycerol glucoside consists of: 1 to 5 percent of glycerin, 0.05 to 1.5 percent of sodium pyrrolidone carboxylate, 0.05 to 0.5 percent of hyaluronic acid, 0.02 to 0.05 percent of EDTA-2Na, 0.02 to 3 percent of glycerol glucoside, 0.02 to 1 percent of D-panthenol, 0.001 to 0.25 percent of 1, 2-pentanediol, 0.02 to 2 percent of essence and the balance of water.
In some embodiments, the cosmetic composition comprising glycerol glucoside consists of: 1 to 5 percent of glycerin, 0.05 to 1.5 percent of sodium pyrrolidone carboxylate, 0.05 to 0.5 percent of hyaluronic acid, 0.02 to 0.05 percent of EDTA-2Na, 0.02 to 1 percent of glycerol glucoside, 0.02 to 1 percent of D-panthenol, 0.001 to 0.25 percent of 1, 2-pentanediol, 0.02 to 2 percent of essence and the balance of water.
In some embodiments, the cosmetic composition comprising glycerol glucoside consists of: 5% of glycerin, 0.1% of sodium pyrrolidone carboxylate, 0.1% of hyaluronic acid, 0.02% of EDTA-2Na, 2% of glycerol glucoside, 1% of D-panthenol, 0.25% of 1, 2-pentanediol, 0.02% of essence and the balance of water.
In some embodiments, the cosmetic composition comprising glycerol glucoside consists of: 3% of glycerin, 0.2% of sodium pyrrolidone carboxylate, 0.5% of hyaluronic acid, 0.05% of EDTA-2Na, 1% of glycerol glucoside, 0.05% of D-panthenol, 0.2% of 1, 2-pentanediol, 0.05% of essence and the balance of water.
In some embodiments, the cosmetic composition comprising glycerol glucoside consists of:
5% of glycerin, 0.1% of sodium pyrrolidone carboxylate, 0.1% of hyaluronic acid, 0.02% of EDTA-2Na, 2% of glycerol glucoside, 1% of D-panthenol, 0.25% of 1, 2-pentanediol, 0.02% of essence and the balance of water.
Further, the cosmetic composition containing the glycerol glucoside consists of the following components:
3% of glycerin, 0.2% of sodium pyrrolidone carboxylate, 0.5% of hyaluronic acid, 0.05% of EDTA-2Na, 1% of glycerol glucoside, 0.05% of D-panthenol, 0.2% of 1, 2-pentanediol, 0.05% of essence and the balance of water.
In a second aspect, the present invention provides a method for preparing the glycerol glucoside-containing cosmetic composition, comprising the steps of:
mixing the components of the phase A, heating to dissolve, keeping the temperature for a set time, and cooling;
cooling the phase A solution to 20-45 ℃, adding each component of the phase B, and stirring until the mixture is uniform and free of insoluble substances;
and adding the component of the phase C into the mixed solution of the phase A and the phase B, uniformly mixing, and filtering to obtain the product.
The phase A contains water, when the phase A is directly mixed with the phase B, the water in the phase A can bring microorganisms into a system, the phase A is heated and then is subjected to heat preservation to achieve the effect of high-temperature sterilization, and A, B, C is added step by step to accelerate the dispersion and dissolution of the high-molecular humectant rheology regulator. The 1, 2-pentanediol is added to improve the antibacterial, antiseptic and mildew-proof effects of the cosmetics. The essence is added to improve the smell of the cosmetic aquatic product.
In some embodiments, the temperature at which phase A components dissolve upon heating is 80-85 ℃.
Further, the heat preservation time is 10-30 min. In order to ensure that all the components of the phase A are fully dissolved.
In some embodiments, the filter cloth has a pore size of 100-1000 mesh.
In a third aspect, the present invention provides the use of the cosmetic composition comprising glycerol glucoside for the preparation of moisturizing water.
The present invention is further illustrated by the following specific examples.
Example 1
Table 1 formulation 1 composition
A toning lotion was prepared according to the formulation in table 1, and the preparation method of the toning lotion comprises the steps of:
1) sequentially adding the phase A raw materials into a main container, and heating to 80 ℃;
2) stirring until no insoluble substance is present, keeping the temperature for 10min, and cooling;
3) cooling to 20 deg.C, adding phase B, stirring until there is no insoluble matter
4) Mixing with the phase C raw material, stirring to be uniform and transparent, slowly adding into the main container, and stirring to be uniform;
5) cooling to room temperature, filtering with 400 mesh filter cloth.
Testing of the properties of the lotions:
1. type I collagen content detection test
Cells in logarithmic growth phase were collected at a cell density of 1.0X 105One/well was inoculated into 12-well plates. In an incubator (37 ℃, 5% CO)2) After 24h of medium incubation, the drug to be tested (formula 1 lotion) was added to it, with 30 μmol/L ascorbic acid (VC) as a positive control, untreated cells as a Negative Control (NC), and reaction system reagents and solvents as solvent controls, with 4 replicate wells per set.
Adding the drug into an incubator (37 ℃, 5% CO)2) Culturing for 72h, and collecting the culture solution. And detecting the content of the type I collagen in the culture solution by adopting a Col IELISA kit.
TABLE 2
The negative control is the type I collagen content in the cells themselves without any component. The positive control is a control which can increase the collagen type I content in the cells after adding a component, which means an effective control. Formula 1 is the formula in table 1, and the content of type I collagen in cells can be much higher than that of a positive control, which indicates that the effect is better.
As can be seen from Table 2, the lotion of formula 1 in Table 1 was effective in achieving anti-aging benefits.
2. Test for quick repair and wrinkle reduction of fine lines in dermis
Human body test conditions:
after cleaning forehead skin of 15 people and 30-50 years old women, applying the toning lotion with the formula in the table 1 on the surface of the forehead skin, and carrying out wrinkle detection by using a skin diagnosis instrument SPIMI (SpIMI), wherein the analysis principle is as follows: light wave parameter images of different levels of the skin are obtained through light wave parameter microscopic imaging, and the deep skin images are subjected to super-resolution imaging analysis through advanced software algorithm processing.
And (3) testing results:
1. directly detecting after smearing, wherein fine lines of the dermis layer are unchanged;
2. after 5 hours of application, the effect reached the dermis and fine lines 1 mm from the skin surface (dermis) disappeared, as shown in fig. 2.
3. In vitro anti-inflammatory and allergy-relieving efficacy assessment (IL-1. beta.)
The test method comprises the following steps: the experiment is divided into 4 groups in total,
1. negative control group (NC);
2. LPS (lipopolysaccharide stimulated cells to produce inflammatory factors) model group: only LPS is added for stimulation without sample pretreatment;
3. sample set (formulation 1): LPS stimulation is carried out after sample pretreatment;
4. positive control group (PC): LPS stimulation was performed after 0.1mg/mL dexamethasone pretreatment.
Collection logarithmCells in the growth phase at a cell density of 4X 105One/well was inoculated into 12-well plates. In an incubator (37 ℃, 5% CO)2) After 24h of medium culture, the drug to be tested (formula 1 lotion and positive control) was added and the mixture was incubated in an incubator (37 ℃ C., 5% CO)2) After the culture is continued for 2h, 1 mu g/mL LPS is added into the model group, the sample group and the positive control group, and the model group, the sample group and the positive control group are put into a cell incubator to be continued for 24 h. And (3) detecting the content of IL-1 beta in the culture solution by adopting a mouse IL-1 beta ELISA kit and taking the supernatant according to the instruction.
TABLE 2
Compared with a control group, the release amount of 1L-1 beta secreted by cells induced by LPS is respectively reduced by 72% and 23%, and the effect is obvious. The cosmetic water of the formula 1 is shown to be capable of effectively reducing the release amount of inflammatory cytokines and has the effects of improving skin inflammation, removing acne, relieving skin redness and allergy and the like.
4. Guaranteed skin elasticity test
Subject: qualified test subject by screening (0-50 years old 15 persons)
Experiment time: 2 hours
The experimental group was formula 1 lotion, and the control group contained 0.5% Hyaluronic Acid (HA). And (3) coating in different areas, measuring the water content value and the water loss value after coating until no visible water exists on the surface, cleaning the arms, and measuring the water content and the water loss value again after 20 minutes in a constant temperature and humidity environment. The results of the experiment are shown in fig. 3 and 4.
Example 2
TABLE 3 formulation composition
A toning lotion was prepared according to the formulation in table 1, and the preparation method of the toning lotion comprises the steps of:
1) sequentially adding the phase A raw materials into a main container, and heating to 80 ℃;
2) stirring until no insoluble substance is present, keeping the temperature for 20min, and cooling;
3) cooling to 25 deg.C, adding phase B, stirring until no insoluble substance is present
4) Mixing with the phase C raw material, stirring to be uniform and transparent, slowly adding into the main container, and stirring to be uniform;
5) cooling to room temperature, filtering with 400 mesh filter cloth.
The toning lotion is subjected to a performance test, and the content of the type I collagen is 68.97 ng/mL.
Example 3
TABLE 4 formulation composition
The preparation method is the same as that of example 1.
The toning lotion is subjected to a performance test, and the content of the type I collagen is 69.53 ng/mL.
Example 4
The difference from example 1 is that: the mass fraction of spirulina extract-glycerol glucoside was 2%, and the rest was the same as in example 1.
The toning lotion is subjected to a performance test, and the content of the type I collagen is 72.17 ng/mL.
Comparative example 1
The difference from example 1 is that: EDTA-2Na was omitted, and the procedure was otherwise the same as in example 1.
The toning lotion is subjected to a performance test, and the content of the type I collagen is 57.23 ng/mL.
Comparative example 2
The difference from example 1 is that: glycerol glucoside is a commercially available glycerol glucoside (obtained by an enzymatic method), and the rest is the same as in example 1.
The toning lotion is subjected to a performance test, and the content of the type I collagen is 45.31 ng/mL.
The above description is only a preferred embodiment of the present application and is not intended to limit the present application, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, improvement and the like made within the spirit and principle of the present application shall be included in the protection scope of the present application.
Claims (10)
1. A cosmetic composition comprising a glycerol glucoside, characterized in that: the composition consists of the following components:
1 to 5 percent of glycerin, 0.05 to 2 percent of sodium pyrrolidone carboxylate, 0.05 to 0.5 percent of hyaluronic acid, 0.02 to 0.05 percent of EDTA-2Na, 0.02 to 5 percent of glycerol glucoside, 0.02 to 1 percent of D-panthenol, 0.001 to 0.25 percent of 1, 2-pentanediol, 0.02 to 2 percent of essence and the balance of water.
2. The glycerol glucoside containing cosmetic composition of claim 1 wherein: water, glycerin, sodium pyrrolidone carboxylate, hyaluronic acid and EDTA-2Na form a phase A, glycerol glucoside, D-panthenol and 1,2 pentanediol form a phase B, and essence is a phase C.
3. Cosmetic composition containing a glycerol glucoside according to claim 1 or 2, characterized in that: the composition consists of the following components: 1 to 4 percent of glycerin, 0.05 to 1.5 percent of sodium pyrrolidone carboxylate, 0.05 to 0.5 percent of hyaluronic acid, 0.02 to 0.05 percent of EDTA-2Na, 0.02 to 5 percent of glycerol glucoside, 0.02 to 1 percent of D-panthenol, 0.001 to 0.25 percent of 1, 2-pentanediol, 0.02 to 2 percent of essence and the balance of water.
4. Cosmetic composition containing a glycerol glucoside according to claim 1 or 2, characterized in that: the composition consists of the following components: 1 to 5 percent of glycerin, 0.05 to 1.5 percent of sodium pyrrolidone carboxylate, 0.05 to 0.5 percent of hyaluronic acid, 0.02 to 0.05 percent of EDTA-2Na, 0.02 to 3 percent of glycerol glucoside, 0.02 to 1 percent of D-panthenol, 0.001 to 0.25 percent of 1, 2-pentanediol, 0.02 to 2 percent of essence and the balance of water.
5. The glycerol glucoside containing cosmetic composition of claim 4 wherein: the composition consists of the following components: 1 to 5 percent of glycerin, 0.05 to 1.5 percent of sodium pyrrolidone carboxylate, 0.05 to 0.5 percent of hyaluronic acid, 0.02 to 0.05 percent of EDTA-2Na, 0.02 to 1 percent of glycerol glucoside, 0.02 to 1 percent of D-panthenol, 0.001 to 0.25 percent of 1, 2-pentanediol, 0.02 to 2 percent of essence and the balance of water.
6. Cosmetic composition containing a glycerol glucoside according to claim 1 or 2, characterized in that: the composition consists of the following components: 5% of glycerin, 0.1% of sodium pyrrolidone carboxylate, 0.1% of hyaluronic acid, 0.02% of EDTA-2Na, 2% of glycerol glucoside, 1% of D-panthenol, 0.25% of 1, 2-pentanediol, 0.02% of essence and the balance of water.
7. Cosmetic composition containing a glycerol glucoside according to claim 1 or 2, characterized in that: the composition consists of the following components:
3% of glycerin, 0.2% of sodium pyrrolidone carboxylate, 0.5% of hyaluronic acid, 0.05% of EDTA-2Na, 1% of glycerol glucoside, 0.05% of D-panthenol, 0.2% of 1, 2-pentanediol, 0.05% of essence and the balance of water.
8. A method for preparing a cosmetic composition containing a glycerol glucoside as claimed in any of claims 1 to 7, characterized in that: the method comprises the following steps:
mixing water, glycerol, sodium pyrrolidone carboxylate, hyaluronic acid and EDTA-2Na, heating for dissolving, keeping the temperature for a set time, and cooling to obtain an A-phase solution;
cooling the phase A solution to 20-45 ℃, adding glycerol glucoside, D-panthenol and 1, 2-pentanediol, and stirring until no insoluble substances exist;
finally, adding essence, mixing uniformly, and filtering to obtain the product.
9. The method for preparing a cosmetic composition containing glycerol glucoside of claim 8, wherein: the temperature for heating and dissolving each component of the A-phase solution is 80-85 ℃;
further, the heat preservation time is 10-30 min;
in some embodiments, the filter cloth has a pore size of 100-1000 mesh.
10. Use of a cosmetic composition containing a glycerol glucoside according to any of claims 1-7 for the preparation of moisturizing waters.
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