CN109288770A - A kind of anti-apolexis composition and its application - Google Patents
A kind of anti-apolexis composition and its application Download PDFInfo
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- CN109288770A CN109288770A CN201811274804.5A CN201811274804A CN109288770A CN 109288770 A CN109288770 A CN 109288770A CN 201811274804 A CN201811274804 A CN 201811274804A CN 109288770 A CN109288770 A CN 109288770A
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- sodium hyaluronate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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Abstract
The invention discloses a kind of anti-apolexis compositions, it is characterized by: containing in the anti-apolexis composition: ascorbyl polypeptide, glycosylglycerol, Sodium Hyaluronate, Fructus Hordei Vulgaris extract, contain ascorbyl polypeptide in anti-apolexis composition of the invention, have the advantages that non-discolouring, it is that product can keep in a long time stable, there is the anti-oxidant of Victoria C simultaneously, the effect of increasing collagen synthesis, it has been also equipped with the function of micromolecule polypeptide simultaneously, micromolecule polypeptide can directly be swallowed by Skin Cell, to regenerate epidermis and dermal cell, accelerate metabolism, to effectively reduce microgroove, wrinkle and skin roughness.Contain glycosylglycerol, Sodium Hyaluronate, Fructus Hordei Vulgaris extract in anti-apolexis composition of the invention simultaneously, four kinds of ingredient compoundings can more fully resist aging, allow product to have and preferably support anti-aging function.
Description
Technical field
The present invention relates to a kind of anti-apolexis composition and its applications.
Background technique
Skin aging refers to that skin function Aging damages, and makes skin to the protective capacities of body, and regulating power etc. declines,
Thus skin does not adapt to the variation of internal and external environment, the change of the appearances integral status such as color, color, form, texture occurs.Skin
The aging of skin is divided into intrinsic aging and extrinsic aging.Intrinsic aging refers to the natural aging that skin increases with the age.Table
It is now whiteness of skin, fine wrinkles, flexibility decrease, cutis laxa etc. occurs.Extrinsic aging is main the reason is that solarization institute
The light aging of cause.Show as wrinkle, cutis laxa, coarse, Beige color dermatodyschroia, telangiectasis, pigment
Spot is formed.
Currently, thering is the ingredient of many anti-agings to be applied in cosmetics, such as vitamins, polypeptide, coenzyme, collagen egg
White, plant extracts etc..Single aging ingredient effect is limited, therefore Multiple components is mostly used to be used in compounding.Such as
CN102462640A discloses a kind of ocean fish skin collagen hydrating and anti-aging cosmetic and preparation method thereof, the marine fish
Collagen moisturizing anti-aging cosmetics mainly include the ocean collagen of 1%-6%, and 0.1%-0.5%'s is transparent
The trehalose of matter acid and 3%-5%.The cosmetics can help the reconstruction of internal collagen and the regeneration of elastic collagen and
It updates, and ultraviolet light can be stopped to the direct irradiation of skin, thus delay skin aging.Also have the advantage that (1) in skin
Upper formation moisture barrier is not easy to evaporate the moisture of skin lost.(2) enhance skin elasticity.(3) ocean collagen with
The compound use of hyaluronic acid can enhance the moisturizing anti-senescence function of cosmetics of the present invention.It is disclosed in CN105708751A
A kind of anti-aging skin care product contains hexapeptide -1, hydrolytic collagen, hexapeptide -5, ginseng root extract, mulberry root extract, glycyrrhiza glabra
One or more of root extract, magnesium ascorbyl phosphate, ginkgo biloba p.e, jujube berry extract, which has
Increase quantity of leucocyte, improve the immunity of the human body, boost metabolism, anti-aging, potent antibacterial sterilization, adjust skin ph value,
The function of preventing melanin from being formed promotes skin corium collagen, elastic fibers regeneration, repairs impaired skin cell, effect
There is decomposition toxin, effectively solve cutis laxa aging, quick thin face draws skin, goes to wrinkle, and can eliminate lead mercury heavy-metal residual, decompose
Skin limb is metabolized rubbish, effectively solves cutis laxa aging, and quick thin face draws skin, goes to wrinkle, and whitening, oil-control tighten pore, reduce
Eye pouch increases elasticity, anti-inflammatory, sterilization, the reparation and healing for accelerating dark sore and whelk, the anti-aging skin care product and the prior art
Compared to cost it is lower, cheaper, in addition this method prepare anti-aging skin care product with production cost it is low, efficient, environmentally friendly
The advantages of.
Above-mentioned anti-aging cosmetics can obtain certain anti-aging effects, but exist between various aging ingredients and match
The problem of 5 property, it is still that row those skilled in the art exist that how reasonably combined aging ingredient is to obtain better anti-aging effects
The problem of constantly studying.
Summary of the invention
The purpose of the present invention is to provide a kind of anti-apolexis composition and its applications.
The technical solution used in the present invention is:
A kind of anti-apolexis composition contains in anti-apolexis composition: ascorbyl polypeptide, glycosylglycerol, hyaluronic acid
Sodium, Fructus Hordei Vulgaris extract, Sodium Hyaluronate is by macromolecular Sodium Hyaluronate and micromolecule hyaluronic acid sodium with mass ratio (0.1~1):
(0.1~1) mixes, and the weight average molecular weight of macromolecular Sodium Hyaluronate is 1800000~2200000, small molecule hyalomitome
The weight average molecular weight of sour sodium is 10000 or less.
Further, ascorbyl polypeptide, glycosylglycerol, Sodium Hyaluronate, Fructus Hordei Vulgaris extract mass ratio be (1~
10): (1~10): (0.05~0.6): (0.1~1).
A kind of anti-aging cosmetics contain the above-mentioned old composition of anti-evil idea in anti-aging cosmetics.
Further, anti-aging cosmetics be anti-aging toner, wherein containing ascorbyl polypeptide, glycosylglycerol,
Sodium Hyaluronate, Fructus Hordei Vulgaris extract, pentanediol, pungent glycol, pure water, Sodium Hyaluronate is by macromolecular Sodium Hyaluronate and small molecule
Sodium Hyaluronate is mixed with mass ratio 1:1.
Further, contain ascorbyl polypeptide 1~10%, glycosylglycerol 1~10%, transparent by percentage to the quality
Matter acid sodium 0.05~0.6%, Fructus Hordei Vulgaris extract 0.1~1%, pentanediol 3~5%, pungent glycol 0.1~0.2%, surplus pure water,
Preferably, ascorbyl polypeptide 2%, glycosylglycerol 2%, Fructus Hordei Vulgaris extract 0.5%, macromolecular Sodium Hyaluronate 0.05%,
Micromolecule hyaluronic acid sodium 0.05%, pentanediol 3%, pungent glycol 0.2%, surplus pure water.
Further, anti-bad aging cosmetic be anti-aging lotion, wherein containing ascorbyl polypeptide, glycosylglycerol, thoroughly
Bright matter acid sodium, Fructus Hordei Vulgaris extract, pentanediol, pungent glycol, saualane, jojoba oil, GTCC, emulsifier, card wave, glycerol, pure water,
Sodium Hyaluronate is mixed by macromolecular Sodium Hyaluronate with micromolecule hyaluronic acid sodium with mass ratio 1:1.
Further, emulsifier is in -10 phosphate of cetostearyl alcohol, dicetyl phosphate and ceteth
One or more kinds of mixtures.
Further, contain ascorbyl polypeptide 1~10%, glycosylglycerol 1~10%, transparent by percentage to the quality
Matter acid sodium 0.05~0.6%, Fructus Hordei Vulgaris extract 0.1~1%, pentanediol 3~5%, pungent glycol 0.1~0.2%, saualane 3~
5%, jojoba oil 1~5%, GTCC 2~6%, emulsifier 0.5~3%, card wave 0.1~1%, glycerol 1~10%, surplus are pure
Water；Preferably, ascorbyl polypeptide 5%, glycosylglycerol 5%, Fructus Hordei Vulgaris extract 0.5%, macromolecular Sodium Hyaluronate
0.05%, micromolecule hyaluronic acid sodium 0.05%, pentanediol 3%, pungent glycol 0.2%, saualane 3%, jojoba oil 2%,
GTCC 3%, emulsifier 1%, card wave 0.2%, glycerol 3%, surplus pure water.
Further, anti-bad aging cosmetic be anti-aging Essence, wherein containing ascorbyl polypeptide, glycosylglycerol,
Sodium Hyaluronate, Fructus Hordei Vulgaris extract, pentanediol, pungent glycol, glycerol, butanediol, card wave, arginine, allantoin, pure water are transparent
Matter acid sodium is mixed by macromolecular Sodium Hyaluronate with micromolecule hyaluronic acid sodium with mass ratio 1:1.
Further, contain ascorbyl polypeptide 1~10%, glycosylglycerol 1~10%, transparent by percentage to the quality
Matter acid sodium 0.05~0.6%, Fructus Hordei Vulgaris extract 0.1~1%, pentanediol 3~5%, pungent glycol 0.1~0.2%, glycerol: 1~
10%, butanediol 2~8%, card wave: 0.1~1%, arginine 0.1~1%, allantoin 0.05~0.2%, surplus pure water；It is excellent
Selection of land, ascorbyl polypeptide 10%, glycosylglycerol 10%, Fructus Hordei Vulgaris extract 1%, macromolecular Sodium Hyaluronate 0.3%, small point
Sub- Sodium Hyaluronate 0.3%, pentanediol 3%, pungent glycol 0.2%, glycerol 4%, butanediol 3%, card wave 0.4%, arginine
0.4%, allantoin 0.2%, surplus pure water.
The beneficial effects of the present invention are:
1, contain ascorbyl polypeptide in anti-apolexis composition of the invention, have the advantages that non-discolouring, be that product can be
It keeps stablizing in long period, while having effects that anti-oxidant, the increase collagen synthesis of Victoria C, while being also equipped with small
The function of molecular polypeptide, micromolecule polypeptide can directly be swallowed by Skin Cell, to regenerate epidermis and dermal cell, be accelerated new
Old metabolism, to effectively reduce microgroove, wrinkle and skin roughness.
2, in anti-apolexis composition of the invention simultaneously contain glycosylglycerol, Sodium Hyaluronate, Fructus Hordei Vulgaris extract, four kinds
Ingredient compounding, can more fully resist aging, allow product to have and preferably support anti-aging function.
Specific embodiment
Below in conjunction with embodiment, the present invention is further explained, it should be appreciated that following embodiment be merely to illustrate the present invention and
It is not used in and limits the scope of the invention.
The weight average molecular weight of macromolecular Sodium Hyaluronate in the present invention is 1800000~2200000, small molecule hyalomitome
The weight average molecular weight of sour sodium is 10000 or less.
Embodiment 1
A kind of anti-aging toner, by percentage to the quality containing ascorbyl polypeptide account for composition 2%, glycerol glucose
Glycosides accounts for the 2% of composition, Fructus Hordei Vulgaris extract and accounts for the 0.5% of composition, macromolecular Sodium Hyaluronate 0.05%, small molecule hyalomitome
Sour sodium 0.05%, pentanediol 3%, pungent glycol 0.2%, remaining be pure water.
Preparation method are as follows: be weighed into pentanediol and pungent glycol, macromolecular Sodium Hyaluronate and micromolecule hyaluronic acid sodium
It is stirred evenly in container, pure water is added, remaining ingredient is added after being completely dissolved to solid in stirring, stirs evenly after dissolving to obtain the final product.
Embodiment 2
A kind of anti-aging lotion, by percentage to the quality containing ascorbyl polypeptide account for composition 5%, glycosylglycerol
It accounts for the 5% of composition, Fructus Hordei Vulgaris extract and accounts for the 0.5% of composition, macromolecular Sodium Hyaluronate 0.05%, micromolecule hyaluronic acid
Sodium 0.05%, pentanediol 3%, pungent glycol 0.2%, saualane 3%, jojoba oil 2%, GTCC 3%, emulsifier 1%, card wave
0.2%, glycerol 3%, remaining be pure water.
Preparation method are as follows:
1, a part of pure water is added after stirring evenly large and small numerator sodium hyaluronate and pentanediol, stirring keeps solid completely molten
Solution.
2, saualane, jojoba oil, GTCC, emulsifier are put into container and are heated with stirring to 85 DEG C.
3, card wave, glycerol, pungent glycol, pure water are added to the container, are heated with stirring to 85 DEG C, homogeneous 5~10 minutes, confirm
Solid cools down after being completely dissolved；Temperature is down to 45 DEG C hereinafter, addition step 1 ingredient and glycosylglycerol and Fructus Hordei Vulgaris extract, are stirred
Up to lotion described in embodiment 2 after even.
Embodiment 3
A kind of anti-aging Essence, by percentage to the quality containing ascorbyl polypeptide account for composition 10%, glycerol Portugal
Glucosides accounts for the 10% of composition, Fructus Hordei Vulgaris extract and accounts for the 1% of composition, macromolecular Sodium Hyaluronate 0.3%, small molecule hyalomitome
Sour sodium 0.3%, pentanediol 3%, pungent glycol 0.2%, glycerol 4%, butanediol 3%, card wave 0.4%, arginine 0.4%, allantois
Plain 0.2%, remaining is pure water.
Preparation method are as follows:
1. a part of pure water is added after pentanediol and large and small numerator sodium hyaluronate are stirred evenly, stirring keeps solid completely molten
Solution.
2. arginine and a part of pure water are weighed into container, stirring is made it completely dissolved.
3. Ka Bo and glycerol, butanediol to be weighed into container and stir evenly, allantoin, pure water is added, stirring is warming up to 85 DEG C,
Matter cools down after being completely dispersed solid, and near 45 DEG C of temperature is hereinafter, be added steps 1 and 2 ingredient and residual components, after stirring evenly to obtain the final product.
Comparative example 1
A kind of toner, containing ascorbic acid glucoside account for the 2% of composition, glycosylglycerol account for composition 2%, it is big
Wheat extract accounts for the 0.5% of composition, macromolecular Sodium Hyaluronate 0.05%, micromolecule hyaluronic acid sodium 0.05%, pentanediol
3%, pungent glycol 0.2%, remaining be pure water.
Preparation method during the preparation method is the same as that of Example 1.
Comparative example 2
A kind of anti-aging lotion, contains by percentage to the quality: Matrixyl 3%, palmitic acid acyl hexapeptide -12 3%, barley
Extract accounts for the 0.5% of composition, macromolecular Sodium Hyaluronate 0.05%, micromolecule hyaluronic acid sodium 0.05%, pentanediol
3%, pungent glycol 0.2%, saualane 3%, jojoba oil 2%, GTCC 3%, emulsifier 1%, card wave 0.2%, glycerol 3%, its
Remaining is pure water.
The preparation method is as follows:
1, a part of pure water is added after stirring evenly large and small numerator sodium hyaluronate and pentanediol, stirring keeps solid completely molten
Solution.
2, saualane, jojoba oil, GTCC, emulsifier are put into container and are heated with stirring to 85 DEG C.
3, card wave, glycerol, pungent glycol, pure water are added to the container, are heated with stirring to 85 DEG C, homogeneous 5~10 minutes, confirm
Solid cools down after being completely dissolved；Temperature is down to 45 DEG C hereinafter, addition step 1 ingredient and Matrixyl, palmitic acid acyl hexapeptide -12, are stirred
After even to obtain the final product.
Comparative example 3
Commercially available certain money publicity has the Essence of fine senile-resistant efficacy.
Comparative example 4
A kind of anti-aging Essence accounts for the 20% of composition, barley containing glycosylglycerol by percentage to the quality and extracts
Object accounts for the 1% of composition, macromolecular Sodium Hyaluronate 0.3%, micromolecule hyaluronic acid sodium 0.3%, pentanediol 3%, pungent glycol
0.2%, glycerol 4%, butanediol 3%, card wave 0.4%, arginine 0.4%, allantoin 0.2%, remaining be pure water.
Preparation method is the same as embodiment 3.
Comparative example 5
A kind of anti-aging Essence accounts for the 20% of composition, barley containing ascorbyl polypeptide by percentage to the quality and mentions
Object is taken to account for the 1% of composition, macromolecular Sodium Hyaluronate 0.3%, micromolecule hyaluronic acid sodium 0.3%, pentanediol 3%, Xin Gan
Alcohol 0.2%, glycerol 4%, butanediol 3%, card wave 0.4%, arginine 0.4%, allantoin 0.2%, remaining be pure water.
Preparation method is the same as embodiment 3.
Comparative example 6
A kind of anti-aging Essence, by percentage to the quality containing ascorbyl polypeptide account for composition 11%, glycerol Portugal
Glucosides accounts for the 10% of composition, macromolecular Sodium Hyaluronate 0.3%, micromolecule hyaluronic acid sodium 0.3%, pentanediol 3%, Xin Gan
Alcohol 0.2%, glycerol 4%, butanediol 3%, card wave 0.4%, arginine 0.4%, allantoin 0.2%, remaining be pure water.
Preparation method is the same as embodiment 3.
Comparative example 7
A kind of anti-aging Essence, by percentage to the quality containing ascorbyl polypeptide account for composition 10%, glycerol Portugal
Glucosides accounts for the 10% of composition, Fructus Hordei Vulgaris extract and accounts for the 1.6% of composition, pentanediol 3%, pungent glycol 0.2%, glycerol 4%, fourth
Glycol 3%, card wave 0.4%, arginine 0.4%, allantoin 0.2%, remaining be pure water.
Preparation method is the same as embodiment 3.
Efficacy test
1, skin elasticity is tested:
1. test equipment:
Elasticity of skin is tested using skin elasticity tester (Cutometer MPA 580), test philosophy is based on suction
With stretching principle, a negative pressure is generated in tested skin surface and specifically tests skin inspiration one in probe, skin quilt
Depth in inspiration test probe is measured by a contactless optic testing system.Including light in test probe
The ratio (emitting the ratio between light and reception light) of transmitter and receiver, light is directly proportional with the depth of skin is inhaled into, thus
Then the relation curve of the length and time that are stretched to a skin confirms the elastic property of skin by MPA software,
Elasticity number is ratio, is up to 1, closer to 1, illustrates that the elasticity of skin is better.
2. test method:
Test is divided into 3 groups, and every group of 20 people of selection (age is between 25~50 years old), each group uses implementation in left face respectively
Example, right face use reference examples, and 2 wipings persistently use 4 weeks, in face with skin elasticity tester (Cutometer sooner or later daily
MPA 580) test the skin elasticity situation of left face and right face.
3. test condition:
Subject before testing after face cleaning at 18~22 DEG C of room temperature, sit quietly in 45~55% environment 30 points by relative humidity
Zhong Hou enjoins it to loosen facial muscles, gently closes eyes, is detected with skin elasticity tester (Cutometer MPA 580)
Its face skin elasticity, probe is averaged in same tested area's duplicate measurements 3 times when measurement.Test is divided into 5 times, is surveyed respectively
Try the elasticity number of the 0th, 1,2,3,4 week skin of subject.
4. test result:
Embodiment 1 and degree 1 test result of ratio
Left face uses the embodiment of the present invention 1, totally 4 weeks, skin elasticity value A is tested, such as table 1；Right face is produced using reference examples 1
Product totally 4 weeks, test skin elasticity value A, such as table 2.Wherein △ A=A (4 weeks)-A (0 week)
Elasticity number A is higher, illustrates that the elasticity of skin is better, and △ A value is the elasticity number and initial flesh using skin after 4 weeks
The difference of skin elasticity number, △ A is bigger, illustrates that the elasticity number of skin is increased more, then the effect of anti-aging is better.
In conjunction with the elastic Value Data and observation subjects skin's state of table 1, it can be seen that use the embodiment of the present invention 1
The skin elasticity of product, subject obviously increases, and the wrinkle of skin is also fewer and fewer, and skin more water profit is full.
From 2 data of table and from subject face it can be concluded that, use the product of reference examples 1, the bullet of subject's skin
Property value also risen, the wrinkle of skin is also thin out, but compares left and right face, can significantly find out that the skin of left face is whole
State is got well than right face, and wrinkle is more shallow.
The △ A value of table 1 is 0.2349, and the △ A value of table 2 is 0.1620, the variation of subject's elasticity of skin, hence it is evident that the present invention
Embodiment 1 is higher than reference examples 1, therefore illustrates, the anti-aging effects for the ascorbyl polypeptide that the present invention uses are better than anti-bad
Hematic acid glucoside.
Embodiment 2 and 2 test result of comparative example
The ascorbyl polypeptide that the embodiment of the present invention 2 uses is substituted on the market relatively broad anti-by reference examples 2
Aging ingredient: Matrixyl and palmityl hexapeptide -12 pass through Experimental Comparison effect.Left face uses the embodiment of the present invention 2, and totally 4
Skin elasticity value A is tested, such as table 3 in week；Right face uses 2 product of reference examples, totally 4 weeks, skin elasticity value A is tested, such as table 4.Its
In, △ A=A (4 weeks)-A (0 week).
Elasticity number A is higher, illustrates that the elasticity of skin is better, and △ A value is the elasticity number and initial flesh using skin after 4 weeks
The difference of skin elasticity number, △ A is bigger, illustrates that the elasticity number of skin is increased more, then the effect of anti-aging is better.
In conjunction with the elastic Value Data and observation subjects skin's state of table 3, it can be seen that use the embodiment of the present invention 2
Product, the skin elasticity of subject, which has, significantly to be increased, and the deep wrinkle of skin is more and more shallow, some dry lines, microgroove disappear,
Skin is also brighter, and overall feeling more healthy water is moistened, full flexible.
From 4 data of table and from subject face it can be concluded that, use the product of reference examples 2, the bullet of subject's skin
Property value also risen, the wrinkle of skin is also thin out, but compares left and right face, can significantly find out that the skin of left face is whole
State is got well than right face, and wrinkle is more shallow.
The △ A value of table 3 is 0.3328, and the △ A value of table 4 is 0.2683, the variation of subject's elasticity of skin, hence it is evident that the present invention
Embodiment 2 is higher than reference examples 2, therefore illustrates, the anti-aging effects for the ascorbyl polypeptide that the present invention uses are better than market
Upper usually used aging ingredient: polypeptide.
Embodiment 3 and 3 test result of comparative example
Left face uses the embodiment of the present invention 3, totally 4 weeks, skin elasticity value A is tested, such as table 5；Right face is produced using reference examples 3
Product totally 4 weeks, test skin elasticity value A, such as table 6.Wherein, △ A=A (4 weeks)-A (0 week).
In conjunction with the elastic Value Data and observation subjects skin's state of table 5, it can be seen that use the embodiment of the present invention 3
Product, the skin elasticity of subject, which has, significantly to be increased, and the wrinkle of skin is also more and more lighter, and skin integrally seems that water profit is full
Full, gloss is fine and smooth.
From 6 data of table and from subject face it can be concluded that, use the product of reference examples 3, the bullet of subject's skin
Property value also risen, the wrinkle of skin is also thin out, but compares left and right face, can significantly find out that the skin of left face is whole
State is got well than right face, and compact, the turgor of left face are better than right face.
The △ A value of table 5 is 0.3934, and the △ A value of table 6 is 0.3489, the variation of subject's elasticity of skin, hence it is evident that the present invention
Embodiment 3 is higher than reference examples 3, therefore illustrates, the commercially available preferable anti-aging product of composition control of the invention is also advantageous,
Effect is more preferable, can achieve better desired effect.
The test result of comparative example 4~7 such as table 7.
From the above results, the △ Aaverage original of comparative example 3 is greater than the △ Aaverage of comparative example 4~7, it is seen that this hair
Four kinds of ingredient compoundings can play better effect in bright composition, lack any of them, the elasticity number variation of skin
It can be substantially reduced, i.e., the effect of anti-aging can weaken significantly.
The test of DPPH free radical scavenging activity
DPPH free radical scavenging activity can characterize the efficiency for removing free radical, so as to judge the anti-aging effect of cosmetics
Fruit, test philosophy are as follows:
1,1- diphenyl -2- trinitrophenyl-hydrazine (DPPH) is a kind of stable nitrogen center organic free radical, DPPH method in
It is suggested within 1958, is widely used in the anti-aging ability of quantitative determination Biosample, phenolic substances and food.This method is basis
DPPH free radical has single electron, there is the last one absorption, alcoholic solution characteristic purple at 517nm.When there is free radical scavenger
In the presence of, so that its absorption is faded away since it is matched with single electron, the electron amount Cheng Ding that fading extent receives with it
Magnitude relation, thus available spectrophotometer carries out quick quantitative analysis, to detect radicals scavenging situation, to evaluate sample
Anti-aging ability, ability indicates that clearance rate is bigger with clearance rate, then shows that the effect of its anti-aging is better.
Reagent: the DPPH- absolute methanol solution of 0.0178mmol/L adds 3ml prepare liquid, after mixing in cuvette
Light absorption value is surveyed at 517nm wavelength immediately, light absorption value is denoted as A1, then surveys light absorption value after 30min is kept in dark place at 37 DEG C, is denoted as
A2, blank control is only plus DPPH- absolute methanol solution, light absorption value are denoted as A0 and calculate DPPH radicals scavenging by following formula
Rate:
DPPH free radical scavenging activity (%)=(1- (A1-A2)/A0) × 100% takes the average value measured three times, detection knot
Fruit is as shown in table 8.
It can be seen that Examples 1 and 2 from the data of table 8 and want excellent using the efficiency of the removing free radical of the present composition
Illustrate the clear of the ascorbyl polypeptide that the present invention uses using ascorbic acid glucoside and peptide composition in reference examples 1,2
Except the ability of free radical is better than some aging ingredients on the market, the removing free radical efficiency of embodiment 3 will also be much higher than
The efficiency of commercial product illustrates that the present composition has excellent antiradical activities, the i.e. anti-aging of the present composition
Effect is very excellent.And the removing free radical efficiency of embodiment 3 is much higher than reference examples 4,5,6,7, no matter illustrates of the present invention group
Any one component for closing object is removed, and the efficiency for removing free radical can be far below the present composition, the i.e. present composition
Composition be the assembled scheme for comparing optimization.
Claims (10)
1. a kind of anti-apolexis composition, it is characterised in that: contain in the anti-apolexis composition: ascorbyl polypeptide, glycerol Portugal
Glucosides, Sodium Hyaluronate, Fructus Hordei Vulgaris extract, Sodium Hyaluronate is by macromolecular Sodium Hyaluronate and micromolecule hyaluronic acid sodium with matter
Amount is than (0.1~1): (0.1~1) mixes, and the weight average molecular weight of macromolecular Sodium Hyaluronate is 1800000~2200000,
The weight average molecular weight of micromolecule hyaluronic acid sodium is 10000 or less.
2. anti-apolexis composition according to claim 1, it is characterised in that: ascorbyl polypeptide, glycosylglycerol, transparent
Matter acid sodium, Fructus Hordei Vulgaris extract mass ratio be (1~10): (1~10): (0.05~0.6): (0.1~1).
3. a kind of anti-aging cosmetics, which is characterized in that containing of any of claims 1 or 2 anti-in the anti-aging cosmetics
Bad old composition.
4. anti-aging cosmetics according to claim 3, the anti-aging cosmetics are anti-aging toner, and feature exists
In: it is transparent containing ascorbyl polypeptide, glycosylglycerol, Sodium Hyaluronate, Fructus Hordei Vulgaris extract, pentanediol, pungent glycol, pure water
Matter acid sodium is mixed by macromolecular Sodium Hyaluronate with micromolecule hyaluronic acid sodium with mass ratio 1:1.
5. anti-aging cosmetics according to claim 4, it is characterised in that: more containing ascorbic acid by percentage to the quality
Peptide 1~10%, glycosylglycerol 1~10%, Sodium Hyaluronate 0.05~0.6%, Fructus Hordei Vulgaris extract 0.1~1%, pentanediol 3
~5%, pungent glycol 0.1~0.2%, surplus pure water, it is preferable that ascorbyl polypeptide 2%, glycosylglycerol 2%, barley are extracted
Object 0.5%, macromolecular Sodium Hyaluronate 0.05%, micromolecule hyaluronic acid sodium 0.05%, pentanediol 3%, pungent glycol 0.2%,
Surplus pure water.
6. anti-ageing cosmetics according to claim 3, the anti-aging cosmetics are anti-aging lotion, it is characterised in that:
Contain ascorbyl polypeptide, glycosylglycerol, Sodium Hyaluronate, Fructus Hordei Vulgaris extract, pentanediol, pungent glycol, saualane, Jojoba
Oil, GTCC, emulsifier, card wave, glycerol, pure water, Sodium Hyaluronate is by macromolecular Sodium Hyaluronate and micromolecule hyaluronic acid sodium
It is mixed with mass ratio 1:1.
7. anti-aging cosmetics according to claim 6, it is characterised in that: emulsifier is cetostearyl alcohol, two cetanols
The mixture of one or more of -10 phosphate of phosphate and ceteth.
8. anti-aging cosmetics according to claim 7, it is characterised in that: more containing ascorbic acid by percentage to the quality
Peptide 1~10%, glycosylglycerol 1~10%, Sodium Hyaluronate 0.05~0.6%, Fructus Hordei Vulgaris extract 0.1~1%, pentanediol 3
~5%, pungent glycol 0.1~0.2%, saualane 3~5%, jojoba oil 1~5%, GTCC 2~6%, emulsifier 0.5~
3%, card wave 0.1~1%, glycerol 1~10%, surplus pure water；Preferably, ascorbyl polypeptide 5%, glycosylglycerol 5%, big
Wheat extract 0.5%, macromolecular Sodium Hyaluronate 0.05%, micromolecule hyaluronic acid sodium 0.05%, pentanediol 3%, pungent glycol
0.2%, saualane 3%, jojoba oil 2%, GTCC 3%, emulsifier 1%, card wave 0.2%, glycerol 3%, surplus pure water.
9. anti-ageing cosmetics according to claim 3, the anti-bad aging cosmetic is anti-aging Essence, and feature exists
In: contain ascorbyl polypeptide, glycosylglycerol, Sodium Hyaluronate, Fructus Hordei Vulgaris extract, pentanediol, pungent glycol, glycerol, fourth two
Alcohol, card wave, arginine, allantoin, pure water, Sodium Hyaluronate is by macromolecular Sodium Hyaluronate and micromolecule hyaluronic acid sodium with matter
Amount is mixed than 1:1.
10. anti-ageing cosmetics according to claim 9, it is characterised in that: more containing ascorbic acid by percentage to the quality
Peptide 1~10%, glycosylglycerol 1~10%, Sodium Hyaluronate 0.05~0.6%, Fructus Hordei Vulgaris extract 0.1~1%, pentanediol 3
~5%, pungent glycol 0.1~0.2%, glycerol: 1~10%, butanediol 2~8%, card wave: 0.1~1%, arginine 0.1~
1%, allantoin 0.05~0.2%, surplus pure water；Preferably, ascorbyl polypeptide 10%, glycosylglycerol 10%, barley mention
Take object 1%, macromolecular Sodium Hyaluronate 0.3%, micromolecule hyaluronic acid sodium 0.3%, pentanediol 3%, pungent glycol 0.2%, sweet
Oily 4%, butanediol 3%, card wave 0.4%, arginine 0.4%, allantoin 0.2%, surplus pure water.
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110327245A (en) * | 2019-08-21 | 2019-10-15 | 广东一华科技有限公司 | A kind of polypeptide freeze-dried powder reparation facial mask |
| CN112245323A (en) * | 2020-11-04 | 2021-01-22 | 广州诺彦生物科技有限公司 | A cosmetic containing glucosyl rutin and glycerol glucoside composition |
| CN112870102A (en) * | 2021-04-07 | 2021-06-01 | 青岛中科蓝智生物科技发展有限公司 | Cosmetic composition containing glycerol glucoside and preparation method and application thereof |
| CN114224768A (en) * | 2021-12-13 | 2022-03-25 | 江苏江山聚源生物技术有限公司 | Repairing and anti-aging composition and preparation method thereof |
| CN114259431A (en) * | 2021-12-29 | 2022-04-01 | 宁波御坊堂生物科技有限公司 | Natural edible high-foaming skin-cleaning ointment and preparation method thereof |
| CN114288202A (en) * | 2021-12-06 | 2022-04-08 | 广州沛妍医疗科技有限公司 | A sericin composition with antiaging effect, and its preparation method |
| CN115517999A (en) * | 2022-10-26 | 2022-12-27 | 广州艾卓生物科技股份有限公司 | Anti-aging composition and application thereof in beauty and skin care |
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| CN110327245A (en) * | 2019-08-21 | 2019-10-15 | 广东一华科技有限公司 | A kind of polypeptide freeze-dried powder reparation facial mask |
| CN110327245B (en) * | 2019-08-21 | 2022-02-11 | 蝶泉(广东)生物科技有限公司 | Polypeptide freeze-dried powder repair mask |
| CN112245323A (en) * | 2020-11-04 | 2021-01-22 | 广州诺彦生物科技有限公司 | A cosmetic containing glucosyl rutin and glycerol glucoside composition |
| CN112870102A (en) * | 2021-04-07 | 2021-06-01 | 青岛中科蓝智生物科技发展有限公司 | Cosmetic composition containing glycerol glucoside and preparation method and application thereof |
| CN114288202A (en) * | 2021-12-06 | 2022-04-08 | 广州沛妍医疗科技有限公司 | A sericin composition with antiaging effect, and its preparation method |
| CN114224768A (en) * | 2021-12-13 | 2022-03-25 | 江苏江山聚源生物技术有限公司 | Repairing and anti-aging composition and preparation method thereof |
| CN114224768B (en) * | 2021-12-13 | 2024-03-15 | 江苏江山聚源生物技术有限公司 | Repairing and anti-aging composition and preparation method thereof |
| CN114259431A (en) * | 2021-12-29 | 2022-04-01 | 宁波御坊堂生物科技有限公司 | Natural edible high-foaming skin-cleaning ointment and preparation method thereof |
| CN115517999A (en) * | 2022-10-26 | 2022-12-27 | 广州艾卓生物科技股份有限公司 | Anti-aging composition and application thereof in beauty and skin care |
| CN115517999B (en) * | 2022-10-26 | 2023-09-15 | 广州艾卓生物科技股份有限公司 | Anti-aging composition and application thereof in beauty and skin care |
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Effective date of registration: 20210705 Address after: 510000 89 Hefeng Road, Huangpu District, Guangzhou City, Guangdong Province Patentee after: Guangzhou Yanzhi Cosmetics Co.,Ltd. Address before: 503, No.8, Changshui Industrial Zone, Wanggang village, Jiahe street, Guangzhou, Guangdong 510080 Patentee before: GUANGZHOU SIHUAN KANGYUAN COSMETIC Co.,Ltd. |