CN102319197A - Wrinkle-removal eye paste and preparation method thereof - Google Patents
Wrinkle-removal eye paste and preparation method thereof Download PDFInfo
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- CN102319197A CN102319197A CN 201110231554 CN201110231554A CN102319197A CN 102319197 A CN102319197 A CN 102319197A CN 201110231554 CN201110231554 CN 201110231554 CN 201110231554 A CN201110231554 A CN 201110231554A CN 102319197 A CN102319197 A CN 102319197A
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Abstract
The invention discloses a wrinkle-removal eye paste and a preparation method. The eye paste comprises a film carrier with liquid medicine, wherein the liquid medicine comprises the components in part by weight: pearl, amber, astragalus membranacus root extraction (polysaccharide), astragalus membranacus root extraction (sponin), poria cocos sclerotium extraction, Chinese matrimony-vine fruit extraction, angelica root extraction (polysaccharide), angelica root extraction (organic acid), VE (Vitamin E), borneol, eye periphery pre-synergist 338Y324, zinc carbonate hydroxide and water/hydrolisis avenin. The eye paste disclosed by the invention has exact effects, no toxic or side effect, obvious wrinkle-removal effects after being used, and good functions of improving the dermatoglyph at eye periphery, and simultaneously, has better moisturizing effects, stronger moisturizing capability and continuous water-locking effects.
Description
Technical field
The present invention relates to a kind of Wrinkle-removing eye paster and preparation method thereof.
Background technology
Eyelid skin is the thinnest skin of human body whole body, along with the growth of physiological age, and the puzzlement of some external factor such as UV light stimulation and disease factor, the linked groups at eyes position and top layer skin, catabiosis such as the easiest generation black eye, eye pouch and wrinkle.
Along with living condition's the improvement and the needs of social communication, people strengthen attention degree healthy, beauty treatment day by day, and various thus cosmetology eyes subsides and eye-care method are just operated and given birth to.The eye that also has some to have crease-resistant effect in the market pastes; " method of Wrinkle-removing eye paster and preparing product " application for a patent for invention like Chinese invention patent prospectus public reported; Number of patent application 200510096492.X, the applying date: 2005.12.07, open day: 2006.08.09.The pharmaceutical composition of its subsides is made up of Aloe, Flos Rosae Rugosae, Rhizoma Polygonati Odorati, Semen Armeniacae Amarum, collagen protein lyophilized powder basically, produces the 10000ml water preparation altogether.Chinese invention patent " anti-falte elastic eye pad " and for example, number of patent application 200910039541.4, the applying date: 2009.5.18, open day: 2009.10.21.These subsides are made up of 24K nanometer gold platinized platinum and the cosmetic material that is coated on the nanometer gold platinized platinum, and its cosmetic material mainly comprises hyaluronate sodium, allantoin, Radix Hamamelidis Mollis distillate, Vb3, plant extraction liquid (comprising EYELISS polypeptide composition, PHYTOLIGHT compound extracting thing and GULCKLIFT xanthan polymer).
Summary of the invention
The invention provides a kind of Wrinkle-removing eye paster and preparation method thereof; This pastes exact efficacy and has no side effect, uses back wrinkle removal effect remarkable; Have and improve the effect of skin texture near the eyes preferably, have moistening effect preferably simultaneously, the stronger ability that moisturizes is arranged and continue lock water effect.
Eye provided by the invention pastes, and comprises the pad pasting carrier that adds medicinal liquid, and said medicinal liquid comprises by containing following compositions in portion by weight to be processed:
The medicinal liquid of above-mentioned composition can add in the pad pasting carrier of existing various forms of using always or material, processes non-woven fabrics type, gel formula or directly becomes the eye of membrane type to paste.
Further, said pad pasting carrier is a non-woven fabrics, also contains following compositions in portion by weight in the said medicinal liquid:
As preferably, also contain following compositions in portion by weight in the above-mentioned medicinal liquid:
BioAegis (commercially available) 20-40
BioCalm (commercially available) 15-32
Neolone Mxp (commercially available) 1-10
The method for preparing that the present invention provides above-mentioned eye to paste, step comprises:
(1) respectively with succinum, crushing pearl, behind 100 mesh sieves, mix excessively with zinc carbonate hydroxide, grind, cross 160 mesh sieves, mixed powder comminution by gas stream to 200 order is subsequent use;
(2) mixed powder that step (1) is obtained mixes the back and adds glycerol with Magnesiumaluminumsilicate, Radix Astragali root extract (polysaccharide), Radix Astragali root extract (saponin), poria cocos sclerotium extract, FRUCTUS LYCII extract, angelica root extract (polysaccharide); Moistening evenly back adds in 410-590 part deionized water; Homogenizing 3min; Agitating heating 80-85 ℃, homogenizing 10min; Being incubated 80-85 ℃ stirred 10-60 minute fast;
(3), stir and add 90-110 part deionized water, water/hydrolysis avenin, angelica root extract (organic acid) down, join in step (2) the gained mixture 80-85 ℃ of insulated and stirred 20min after stirring with butanediol disperse yellow virgin rubber in advance;
(4) the olive oil PEG-7 esters and the VE that get said amount are in 80 ℃ of heating, and mixing under homogenizing (the preferred rotating speed 1200rpm-1600rpm) condition, filters and joins in step (3) the gained mixture homogenizing 3min, insulated and stirred (500-600rpm) 30min;
(5) step (4) gained mixture is cooled to 50 ℃, the butanediol solution and the eye that add propylene glycol, the Borneolum Syntheticum of said amount enclose prewired mixture 338Y324, stir (preferred 500-600rpm) evenly.Wherein, the butanediol solution of said Borneolum Syntheticum is for to be dissolved in the solution in 0.95-9.5 part butanediol with said amount Borneolum Syntheticum, and the surplus butanediol is used for the disperse yellow virgin rubber in step (3).
(6) step (5) gained mixture is cooled to 35 ℃, processes eye in the packing adding pad pasting behind the ageing 24h and paste.
Said method further is preferably:
Also added in the said step (3) and joined in step (2) the gained mixture 80-85 ℃ of insulated and stirred 20min after BioAegis and BioCalm stir; After said step (5) obtains mixture and is cooled to 40 ℃, add the Neolone Mxp of said amount again, stir (preferred rotating speed 500-600rpm) mix homogeneously.
The traditional Chinese medical science thinks that wrinkle is Time fleets past, and essence and blood secretly consumes, due to the hematogenous blockage, failure of skin and muscle to be nourished.The spleen and stomach provide the material basis of the acquired, and source of generating QI and blood is so get the Radix Astragali, Poria invigorating the spleen and benefiting QI hemopoietic; Blood stored in the liver, kidney storing essence is so with the essence and blood of Fructus Lycii nourishing the liver and kidney, the Radix Angelicae Sinensis blood circulation promoting and enriching moistens foster skin; Be equipped with the succinum promoting blood circulation to remove blood stasis; The pearl whitening granulation promoting; Zinc carbonate hydroxide convergence granulation promoting; The Borneolum Syntheticum clearing heat for detumescence; Play the skin moistening that nourishes blood altogether, the crease-resistant merit of removing stricture of vagina.Modern pharmacology research shows that our effective ingredient can reduce the aging of collagen fiber in the dermal tissue, elastic fiber, improves circulation near the eyes, the skin that effectively compacts, opposing wrinkle.Eye of the present invention pastes and just is being based on that above-mentioned research obtains, and through being affixed on portion near the eyes outward, its curative effect can access maximum performance, has following effect:
1, rigorous, the exact efficacy of scientific formulation has no side effect.
2, adopt the broken technology of Chinese medicine ultra-fine powder that the key component in the prescription is prepared, make drug micronization, be easy to through mucocutaneous, the action effect of main effective ingredient is remarkable.
3, the efficacy study test result shows: the present invention uses back wrinkle removal effect remarkable, has and improves the effect of skin texture near the eyes preferably, has moistening effect preferably simultaneously, the stronger ability that moisturizes is arranged and continue lock water effect.
4. human body zest and patch experimental studies results show, the present invention is safe and non-stimulating, and human body is had no adverse reaction.Irritation test shows, the present invention's (interpolation concentration of mole percent 800ppm and 6400ppm) equal nonirritant under RBC Test System test system.The experiment of human body patch all experimenters all have no adverse reaction, and explains that the present invention has no adverse reaction to human body.
Description of drawings
Fig. 1 is two and pastes use back skin coarseness situation of change;
Fig. 2 is two and pastes use back skin coarseness reduction rate situation of change;
Fig. 3 is two and pastes the relative reduction rate situation of change of use back skin coarseness;
Fig. 4 is two and pastes use back skin mean roughness situation of change;
Fig. 5 is two and pastes use back skin mean roughness reduction rate situation of change;
Fig. 6 is two and pastes the relative reduction rate situation of change of use back skin mean roughness;
Fig. 7 is two and pastes use back skin maximal roughness situation of change;
Fig. 8 is two and pastes use back skin maximal roughness reduction rate situation of change;
Fig. 9 is two and pastes the relative reduction rate situation of change of use back skin maximal roughness;
Figure 10 is two and pastes use back skin mean depth situation of change;
Figure 11 is two and pastes use back skin mean depth reduction rate situation of change;
Figure 12 is two and pastes the relative reduction rate situation of change of use back skin mean depth;
Figure 13 is two and pastes use back skin arithmetic average roughness situation of change;
Figure 14 is two and pastes use back skin arithmetic average roughness reduction rate situation of change;
Figure 15 is two and pastes the relative reduction rate situation of change of use back skin arithmetic average roughness;
Figure 16 is that SDS detects the erythrocyte integrity;
Figure 17 is the microphotograph of erythrocyte.
" crease-resistant eye pastes " is eye subsides of the present invention among the above-mentioned figure.
The specific embodiment
Below in conjunction with accompanying drawing and specific embodiment the present invention is described further so that those skilled in the art can better understand the present invention and implementing, but the embodiment that lifts not conduct to qualification of the present invention.
Medicine embodiment consumption of the present invention is (weight portion) as follows:
The preparation process that above-mentioned eye pastes is:
(1) respectively with succinum, crushing pearl, behind 100 mesh sieves, mix excessively with zinc carbonate hydroxide, grind, cross 160 mesh sieves, mixed powder comminution by gas stream to 200 order is subsequent use;
(2) mixed powder that step (1) is obtained mixes the back and adds glycerol with Magnesiumaluminumsilicate, Radix Astragali root extract (polysaccharide), Radix Astragali root extract (saponin), poria cocos sclerotium extract, FRUCTUS LYCII extract, angelica root extract (polysaccharide); Moistening evenly back adds in the deionized water; Homogenizing 3min; Agitating heating 80-85 ℃, homogenizing (rotating speed 1200rpm-1600rpm) 10min; Be incubated 80-85 ℃ and stirred (700-800rpm) 10-60 minute fast;
(3) with butanediol disperse yellow virgin rubber in advance; Stir and add deionized water, water/hydrolysis avenin, angelica root extract (organic acid), BioAegis (or not adding) and BioCalm (or not adding) down; Join in step (2) the gained mixture 80-85 ℃ of insulated and stirred 20min after stirring;
(4) the olive oil PEG-7 esters and the VE that get said amount are in 80 ℃ of heating, and mixing under homogenizing (rotating speed 1200rpm-1600rpm) condition, joins in step (3) the gained mixture homogenizing 3min, insulated and stirred (500-600rpm) 30min after the filtration;
(5) step (4) gained mixture is cooled to 50 ℃, adds the propylene glycol of said amount, the butanediol solution of Borneolum Syntheticum (Borneolum Syntheticum is dissolved in 0.95-9.5 part butanediol solution in advance) and eye and enclose prewired mixture 338Y324, it is even to stir (500-600rpm).
(6) step (5) gained mixture is cooled to 40 ℃, adds the Neolone Mxp of said amount, stir (500-600rpm) mix homogeneously;
(7) step (6) or (5) gained mixture are cooled to 35 ℃, packing behind the ageing 24h, every couple of pad pasting adding 4.8g processes eye patch of the present invention in the present embodiment.
Deionized water of the present invention is 500～700 parts, and deionized water adds the people at twice, in step 2, adds deionized water 410-590 part, in step 3, adds deionized water 90-110 part; Butanediol is 70～95 parts, in step 3, adds 69.05-85.5 part, in step 5, adds 0.95-9.5 part.
The method for distilling of said Radix Astragali root extract (polysaccharide), Radix Astragali root extract (saponin), poria cocos sclerotium extract, FRUCTUS LYCII extract, angelica root extract (polysaccharide), angelica root extract various extracts such as (organic acid) is a prior art, and the present invention is not described further.Said pad pasting for example can use non-woven fabrics or the acceptable material of other human body to process.
BioAegis (stimulation inhibitory factor), BioCalm (antipruritic and antipruritic agent) can obviously improve eye and paste the zest to skin; Reduce irritated; Neolone Mxp (phenoxyethanol/methyl hydroxybenzoate/propyl hydroxybenzoate/Methylisothiazolinone/water) makes eye paste more stable quality, and above-mentioned composition is available from the many fragrant bio tech ltds of Beijing China.
The wrinkle of skin effect is remarkable near the eyes to improving in the present invention, and is safe and non-stimulating, as follows with relevant result of study report at present:
One, function of delaying senility evaluation
Method: the experimenter amounts to 32 people.Concrete sex composition and age structure are confirmed at random.Volunteer's age is all between 30～55 years old.Wherein: 6 of male, 26 of women.
1. select the left and right arm of experimenter cycle labeling successively: tried zone and white space;
2. the skin texture degree before using the multi-functional skin mirror of MicroSkin II image analysis system determination experiment position to make to apply some make up by the technical staff.
3. sooner or later receiving examination zone and contrast to be tried the zone at sample every day uses a few money eyes to paste that (sample receives the examination district to use eye of the present invention to paste (embodiment 1 crease-resistant eye subsides); Contrast is tried to distinguish uses the contrast eye of outsourcing to paste; Contrast eye adhesion product company is a Shanghai herborist cosmetics company limited; Name of product is: the herborist eye mask), white space does not use any sample; Experimental session, the experimenter can not smear any cosmetics at the experiment position.
The experimenter make continuously the week that applies some make up, two weeks, three weeks and all around after, same weekly time experimenter will smear the position and clean, and use the multi-functional skin mirror of MicroSkin II image analysis system to measure the spreader portion bit value by the tester.
5. the statistics experimenter tests the numerical value that the position records at every turn, carries out t check, analyzing skin change color rule with the SPSS system.
The result:
The skin texture situation of change:
Reduction rate=(number of sets of sample is according to Tn-initial value T0)/initial value T0*100%
Suitable reduction rate=(number of sets of sample is according to Tn-matched group data Tn)/matched group data Tn*100%
1, skin coarseness (Skin Roughness SR)
Be in all sections of skin, with the difference between maximum gray scale peak value and the minimal gray peak value on the straight line.This parameter is the maximum height of skin surface unevenness.
The result: analysis result sees Fig. 1-Fig. 3 for details.
(1) two subsides uses back skin coarseness after use to reduce always, and promptly skin coarseness obviously descends.
(2) relative initial value, two is pasted and uses the back from second significant difference (p＜0.05) that comes into existence.
2, skin mean roughness (Skin Average Roughness SAR)
The arithmetic equal value of FANGPI mound profile about the baseline of target skin; Promptly in limit section; Be divided into 5 five equilibriums by the limitation of length; Obtain every section earlier with the difference between baseline epithelium mound profile (maximum gradation value) and the baseline hypodermis mound profile (minimum gradation value), promptly skin coarseness asks the roughness average (arithmetic mean of instantaneous value) in this length baseline to be the skin mean roughness afterwards again.The number of this parameter and wrinkle of skin what, thickness, the depth have confidential relation.
The result: analysis result sees Fig. 4-Fig. 6 for details.
(1) two subsides uses back skin mean roughness to reduce always, and promptly the skin mean roughness obviously descends.
(2) relative initial value, two is pasted use back mean roughness reduction rate, in the significant difference (p＜0.05) that came into existence in second week.
Skin mean roughness effect all has clear improvement after (3) two subsides are used.
3, maximal roughness (Maximum Roughness MR)
Finger in the skin section face that is cut, the maximum between the peak valley of maximum gray scale peak value adjacent on the straight line and minimal gray peak value.Promptly be equivalent to the central wrinkle of maximum of skin texture.
The result: analysis result sees Fig. 7-Fig. 9 for details.
(1) two subsides uses back skin maximal roughness to reduce always, and promptly the skin maximal roughness obviously descends.
(2) two are pasted use back skin maximal roughness reduction rate since second week all having significant difference (p＜0.05).
4, mean depth (Skin Smoothness Depth SSD)
Two peak values of feeling the pulse with the finger-tip mark skin mound peak (maximum gradation value curve) and sulci of skin minimum point (minimal gray curve) are seen average distance.It is the average distance between skin surface contour line peak and the wrinkle of skin bottom line minimum point.
The result: analysis result sees accompanying drawing 10-12 for details.
(1) two subsides uses back skin mean depth to reduce always, and promptly the skin mean depth obviously reduces.
(2) two are pasted the skin mean depth improvement of use back obviously, from the significant difference (p＜0.05) that came into existence in second week.
5, arithmetic average roughness (Arithmetic Average Roughness AAR)
Grey scale curve is to the range averaging value of average gray value on the feeling the pulse with the finger-tip mark skin straight line.Promptly in the straight length scope, the arithmetic mean of instantaneous value of the absolute value that each point to profile center line distance leaves on the tested skin surface contour line.
The result: analysis result sees Figure 13-Figure 15 for details.
(1) two subsides uses back skin arithmetic average roughness to reduce always, and promptly the skin arithmetic average roughness obviously reduces.
(2) two are pasted the skin arithmetic average roughness improvement of use back obviously, from the significant difference (p＜0.05) that came into existence in second week.
Two, zest test result
Experimental technique:
With reference to ECVAM DB-ALM:INVITTOX protocol; Red Blood Cell Test System INVITTOX n ° 37, hereinafter to be referred as RBC Test System.
The ultimate principle of RBC Test System is to measure the damage of chemicals cell membrane and the change of the cell membrane permeability that therefore causes; Estimate the degree of injury of cell membrane through the amount of measuring the hemoglobin from erythrocyte, spill, this degree of injury has directly related property with the zest of product.
The absorbance of the erythrocyte suspension after the effect of use spectrophotometry chemicals can calculate hemolysis rate and H50 value (even hemolytic concentration value that is tried thing takes place 50% erythrocyte).Correlation analysis showed concordance is preferably carried out in the result that this H50 value and two kinds of standards of grading of Draize test are maximum average value (MAS) and 24h threshold and the scoring of composition parameter (cornea, conjunctiva, iris) thereof.Under same concentrations, the high more zest stronger (using embodiment 11 said eyes to paste in this test) that shows sample of the hemolysis rate of sample.
The result:
1, the assessment of RBC integrity
According to stipulating in the RBC Test System method, use mass ratio by 0.10% sodium lauryl sulphate (SDS) detect the integrity of collection erythrocyte, examine under a microscope the form of erythrocyte and the integrity of cell membrane simultaneously.
The result sees Figure 16 and Figure 17, adds SDS among Figure 16 to be: SDS content is 0.10% PBS diluent.
The H50 that can be got this erythrocyte by Figure 16 is about 30.6 * 10-6 (ppm), meets the setting in the Test System standard: (29.4 ± 3.7) * 10-6 (ppm).
Figure 17 is presented at microscopically, and erythrocyte form and cell membrane are all complete, meet requirement of experiment.
2, sample stimulus property testing
1. (the interpolation concentration of 80 * 10-5) under the low concentration, hemolysis rate of the present invention is about 7.23%, and it is less that eye of the present invention pastes the damage of (embodiment 3) cell membrane, proves that eye of the present invention is attached to no intense stimulus property under the RBC Test System test system.
2. under the high concentration, under the full test concentration of this test system (the interpolation concentration of 640 * 10-5), the hemolysis rate that eye of the present invention pastes (embodiment 3) is about 7.23%.Prove that eye of the present invention is attached to nonirritant under the RBC Test System test system.
Three, human body patch experimental result
Experimentation: the experimenter amounts to 30 people, concrete sex composition and age structure definite at random (meet " diagnostic criteria of cosmetics contact dermatitis and treatment principle " included in, exclusion standard).Select qualified patch material for use, put into speckle examination device after sample is soaked into filter paper, control wells is blank (declining any material).Eye of the present invention is pasted the bent side of forearm that sample (embodiment 3) and blank all are affixed on the experimenter, make it to stick equably on skin lasting 24h with light pressure of palm.Interval 30min behind the removal patch device treats to observe dermoreaction after impression disappears.24h and 48h observe once respectively again behind the patch test, observe dermoreaction.
Criterion:
Judge according to " diagnostic criteria of cosmetics contact dermatitis and treatment principle " classification: being tried the position reactionless is (0); Skin light red speckle occurs and is (1); Skin erythema, infiltration or pimple occur and is (2); Edematous erythema appears in skin, pimple is (3), and it is (4) that remarkable redness, companion's pimple or bulla appear in skin.
The number that occurs 2 grades of skin adverse reactions in 30 examples is more than 2 examples, or any 1 example occurs more than 3 grades or 3 grades during skin adverse reaction, judges that being tried thing has untoward reaction to human body.
Concrete outcome is estimated as shown in the table:
Table 4
Experimental result shows: eye provided by the invention pastes human body is had no adverse reaction.
Claims (5)
1. a Wrinkle-removing eye paster comprises the pad pasting carrier that adds medicinal liquid, it is characterized in that, said medicinal liquid is processed by containing following compositions in portion by weight:
2. eye according to claim 1 pastes, and it is characterized in that said pad pasting carrier is a non-woven fabrics, also contains following compositions in portion by weight in the said medicinal liquid:
3. eye according to claim 2 pastes, and it is characterized in that, also contains following compositions in portion by weight in the said medicinal liquid:
4. the method for preparing of the said Wrinkle-removing eye paster of claim 2 is characterized in that, comprises the steps:
(1) respectively with succinum, crushing pearl, behind 100 mesh sieves, mix excessively with zinc carbonate hydroxide, grind, cross 160 mesh sieves, mixed powder comminution by gas stream to 200 order is subsequent use;
(2) mixed powder that step (1) is obtained mixes the back and adds glycerol with Magnesiumaluminumsilicate, Radix Astragali root extract (polysaccharide), Radix Astragali root extract (saponin), poria cocos sclerotium extract, FRUCTUS LYCII extract, angelica root extract (polysaccharide); Moistening evenly back adds in 410-590 part deionized water; Homogenizing 3min; Agitating heating 80-85 ℃, homogenizing 10min; Being incubated 80-85 ℃ stirred 10-60 minute fast;
(3), stir and add 90-110 part deionized water, water/hydrolysis avenin, angelica root extract (organic acid) down, join in step (2) the gained mixture 80-85 ℃ of insulated and stirred 20min after stirring with butanediol disperse yellow virgin rubber in advance;
(4) the olive oil PEG-7 esters and the VE (tocopherol acetas) that get said amount are in 80 ℃ of heating, and mixing under the processing condition, filters and joins in step (3) the gained mixture homogenizing 3min, insulated and stirred 30min;
(5) step (4) gained mixture is cooled to 50 ℃, the butanediol solution and the eye that add propylene glycol, the Borneolum Syntheticum of said amount enclose prewired mixture 338Y324, stir.Wherein, the butanediol solution of said Borneolum Syntheticum is for to be dissolved in the solution in 0.95-9.5 part butanediol with said amount Borneolum Syntheticum, and the surplus butanediol is used for the disperse yellow virgin rubber in step (3).
(6) step (5) gained mixture is cooled to 35 ℃, processes eye in the packing adding pad pasting behind the ageing 24h and paste.
5. the method for preparing of pasting like the said eye of claim 4 is characterized in that, has also added in the said step (3) to join step (2) institute compound after BioAegis and BioCalm stir and get in the mixture 80-85 ℃ of insulated and stirred 20min; After said step (4) obtains mixing and is cooled to 40 ℃, add the Neolone Mxp of said amount again, mix.
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| CN103536520A (en) * | 2013-10-18 | 2014-01-29 | 桂林雪芙莲日化有限公司 | Hydrating eye mask |
| CN104548057A (en) * | 2014-12-23 | 2015-04-29 | 韦冬梅 | Eye mask which is nutritious, anti-wrinkle and anti-radiation and method for preparing eye mask |
| CN107773506A (en) * | 2016-08-24 | 2018-03-09 | 张文闻 | A kind of eye sticker and preparation method thereof |
| CN107875079A (en) * | 2017-10-18 | 2018-04-06 | 马应龙药业集团股份有限公司 | One kind goes fat granule elite and preparation method thereof |
| US10117827B2 (en) * | 2013-12-08 | 2018-11-06 | Y&B Mother's Choice Ltd. | Preparations for suppressing or attenuating ocular irritancy |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US10434058B2 (en) | 2010-12-09 | 2019-10-08 | Y&B Mother's Choice Ltd. | Natural formulations |
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| CN107773506A (en) * | 2016-08-24 | 2018-03-09 | 张文闻 | A kind of eye sticker and preparation method thereof |
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Application publication date: 20120118 |