CN107875079A - One kind goes fat granule elite and preparation method thereof - Google Patents

One kind goes fat granule elite and preparation method thereof Download PDF

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Publication number
CN107875079A
CN107875079A CN201711454008.5A CN201711454008A CN107875079A CN 107875079 A CN107875079 A CN 107875079A CN 201711454008 A CN201711454008 A CN 201711454008A CN 107875079 A CN107875079 A CN 107875079A
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CN
China
Prior art keywords
elite
fat granule
mixture
fat
granule
Prior art date
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Granted
Application number
CN201711454008.5A
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Chinese (zh)
Other versions
CN107875079B (en
Inventor
陈平
周丽
鲁青
陈雅芬
张衡
孙金龙
周道年
范彦博
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Wuhan Ma Yinglong Da Health Co., Ltd.
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Mayinglong Pharmaceutical Group Co Ltd
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Publication of CN107875079A publication Critical patent/CN107875079A/en
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Publication of CN107875079B publication Critical patent/CN107875079B/en
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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4946Imidazoles or their condensed derivatives, e.g. benzimidazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60Sugars; Derivatives thereof
    • A61K8/602Glycosides, e.g. rutin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67Vitamins
    • A61K8/678Tocopherol, i.e. vitamin E
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/735Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/008Preparations for oily skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/06Preparations for care of the skin for countering cellulitis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/08Anti-ageing preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/70Biological properties of the composition as a whole
    • A61K2800/72Hypo-allergenic

Abstract

The invention discloses one kind to go fat granule elite, and in parts by weight, the effect of going fat granule elite material composition includes:Allantoin, asiaticosid, wolfberry fruit extract, angelica extract, VE, hyaluronic acid, witch hazel, elder, Matrixyl3000 and thickener, NMF, stabilizer, skin conditioning agent and preservative;Scientific formula of the present invention is rigorous, effective component analysis is reasonable;Formula safety is gentle non-stimulated;Secondly, product workability of the present invention is strong, can prevent grease grain from growing, and can reach certain therapeutic action simultaneously, grease grain is reduced or is disappeared;Furthermore of the invention goes fat granule elite while fat granule effect is gone, using be above also equipped with moistening, moisturizing, outward appearance are salubrious, non-greasy the characteristics of.

Description

One kind goes fat granule elite and preparation method thereof
Technical field
The present invention relates to field of pharmaceutical preparations, specifically, is related to a kind of prevention fat granule and reduces or eliminates fat granule Go fat granule elite and preparation method thereof.
Background technology
Fat granule is as produced by endopathic cause and external factor.Endopathic cause is due to body endocrinopathy, causes oil Fat secretion is superfluous;External factor is excessive use frosted, exfoliating product etc. because skin cleaning does not thoroughly cause pore to block Cause eye circumference skin atomic small wound occur, the small tumour of white is produced during skin self-regeneration.
The formation of milium has relation with genetic constitution, and it is stayed originating from epidermis or the benign goitre of appendicle epithelium or storage Property tumour, its profile is similar to calculus, and in yellow-white, about needle point or small rice grain size, the small lump of white can be seen by being needled with pin.When Skin not enough cleans, and such as uses dense eye shadow color make-up product, or excessive use scrub cream, exfoliating product etc. for a long time, all Eye circumference skin can be made atomic wound that is small, can not visually discovering occur, and then white is produced during skin self-regeneration Small tumour --- milium.Dry skin, and the product higher using degree is moistened can be felt by generally occurring within the people of this problem, because It is misfortune that fat granule elite is invited that this, which can typically take for this,.In fact, the male and children that rare skin care is realized are clinically And " victim " of common milium.Summing up the reason for forming fat granule mainly includes the following aspects:
1. bad cosmetic custom causes wound:Scrub cream or exfoliating product excessively are used, is easily produced on skin Small wound, skin is caused to generate the small tumour of white during self-regeneration.
2. fat metabolic disturbance:Skin oil and fat can not be evenly distributed, and cause part to cross Sheng phenomenon, so as to cause eye circumference small The generation of particle.
3. inappropriate skin care:To avoid wrinkle from occurring too early, many women blindly think quality it is partially oily remove fat granule Elite can allow skin to become soft, and the fat granule elite of going for hardly realizing oil is difficult to be absorbed by the skin, and unnecessary grease is all accumulated Pore is blocked in eye circumference, so as to cause short grained appearance.
4. makeup removing is not thorough:Some women are delithted with the dense eye make-up of picture, be often made again during makeup removing not enough carefully, week Arrive, thus easily cause clogging of pores, so as to induce the short grained generation of eye circumference.
Fat granule (milium) is always the skin disease for perplexing the Ms that likes to be beautiful, and is apt to occur in eyelid and cheek, forehead, because of its generation There is certain relation using skin care item with inappropriate so that the intelligent that likes to be beautiful is weighed down with anxieties when selecting beauty skin care product, it may be said that Fat granule (milium) is U.S. eye skin makeup " complication ", " sequelae ".
Fat granule (milium) is the benign goitre or the storage property stayed tumour of epidermis or appendicle epithelium, and some may be with heredity Constitution is relevant, unsatisfactory using medicine or cosmetic effect merely, even if there is certain effect, will also tend to stimulate instead Should, but this special onset position of eyelid constrains its use, so clinic is chosen mostly using pin or laser therapy, it is easy It is easy, get instant result, be still the first choice for solving the problems, such as this skin at present.The product orientation should prevented as can be seen here Aspect, rather than treatment aspect.It is a to take good care of skin, anti-aging, and without blocking pore, and fat granule can be prevented Eye gel one solve consumer's trouble and worry, popular favor will necessarily be obtained, market prospects are had an optimistic view of.
The content of the invention
The present invention is directed to the deficiencies in the prior art, it is therefore an objective to and one kind is provided and goes fat granule elite, fat granule essence Huaan is complete gentle non-stimulated;It and usability is strong, can prevent grease grain from growing, and certain therapeutic action can be reached simultaneously, make oil Fat granule reduces or disappeared;Furthermore of the invention goes fat granule elite while fat granule effect is gone, using being above also equipped with growing The characteristics of profit, moisturizing, outward appearance are salubrious, non-greasy.
Another object of the present invention is to be the provision of a kind of preparation method for going fat granule elite, preparation method letter Single feasible, cost is cheap, is adapted to large-scale production, has broad application prospects.
To achieve these goals, this invention takes following technical measures:
One kind goes fat granule elite, and in parts by weight, the effect of going fat granule elite material composition includes:
Preferably, the effect of going fat granule elite material composition includes:
In addition, the material composition for going fat granule elite also includes thickener, NMF, stabilizer, skin conditioning agent With the one or more in preservative.
Preferably, the thickener is EMT-10 (hydroxy-ethyl acrylate/sodium acryloyldimethyl taurate copolymers), institute One or more of the NMF in glycerine, butanediol are stated, the stabilizer is EDETATE SODIUM, and the skin conditioning agent is selected from One or more, described preservative in glycine betaine, olive oil PEG-7 fat isMTI。
Preferably, in parts by weight, the dosage of each composition is as follows:
And present invention also offers the preparation method that this goes fat granule elite, specifically comprise the following steps:
(1) first, form by weight and EMT-10 is scattered in glycerine, butanediol, then add corresponding parts by weight Water, allantoin, asiaticosid, wolfberry fruit extract, angelica extract, EDETATE SODIUM and glycine betaine, heating stirring is uniform, must mix Thing a;
(2) the mixture a of step (1) is mixed with olive oil PEG-7 fat, VE, stirred, homogeneous 3-5min must be mixed Thing b;
(3) the mixture b that rapid (2) obtain is cooled to 60-65 DEG C, sequentially add hyaluronic acid, witch hazel, elder, Matrixyl3000, stirring, is uniformly dissolved to obtain mixture c;
(4) the mixture c that step (3) obtains is cooled to 35-38 DEG C, and stopping, which is stirred, must remove fat granule elite product.
Preferably, described preparation method, specific steps include:
(1) first, form by weight and EMT-10 is scattered in glycerine, butanediol, then add corresponding parts by weight Water, allantoin, asiaticosid, wolfberry fruit extract, angelica extract, EDETATE SODIUM and glycine betaine, heating stirring is uniform, must mix Thing a;
(2) the mixture a of step (1) is mixed with olive oil PEG-7 fat, VE, stirred, homogeneous 3-5min must be mixed Thing b;
(3) the mixture b that rapid (2) obtain is cooled to 60-65 DEG C, sequentially add hyaluronic acid, witch hazel, elder, Matrixyl3000, stirring, is uniformly dissolved to obtain mixture c;
(4) when mixture c temperature is down to below 45 DEG C, addMTI, stir to obtain mixture d;
(5) the mixture d that step (4) obtains is cooled to 35-38 DEG C, and stopping, which is stirred, must remove fat granule elite product.
The present invention compared with prior art, has following following advantage and effect:
(1) present invention for fat granule Producing reason and pathogenesis and creativeness develops rational formula, wherein, Allantoin promotion organization grows, cell metabolism, cutin-softening layer albumen;Asiaticosid has promotion Wound Healing;Thoroughly Bright matter acid has good moisture-keeping function;Witch hazel is releived, convergence, the effect of oil-control;REDULITE (elder) is a kind of Fat-reducing, Firm and traditional fat-splitting agent are to treat the essential new tool of cellulitis;In addition, in basic components On the basis of, also appropriate increase, which is supported, holds aging ingredient, such as Matrixyl3000 (crease-resistant, anti-aging), vitamin e;The present invention matches somebody with somebody Side mutually cooperates with, worked in coordination, and causes that the present invention goes fat granule elite to possess excellent to go fat granule effect on the whole;
(2) scientific formula of the present invention is rigorous, effective component analysis is reasonable;Formula safety is gentle non-stimulated;Secondly, the present invention Product workability is strong, can prevent grease grain from growing, and can reach certain therapeutic action simultaneously, grease grain is reduced or is disappeared; Furthermore of the invention goes fat granule elite while fat granule effect is gone, using be above also equipped with moistening, moisturizing, outward appearance are salubrious, The characteristics of non-greasy.
Embodiment:
Technical scheme is described in further detail below in conjunction with specific embodiments.It should be understood that institute Purpose for embodiment is present disclosure is expanded on further, and can not be construed to protect the present invention in any sense The limitation of scope.
Embodiment 1:
One kind goes fat granule elite, and in terms of parts by weight, the effect of going fat granule elite material composition includes:
In the present embodiment, EMT-10 matches the product (name of product of BIC Corp (SEPPIC) purchased from France: SepinovEMT10, product composition:Hydroxy-ethyl acrylate/sodium acryloyldimethyl taurate copolymers).
MTI refers to the iodo- 2-propynyl butyl carbamates of MIT/3-.
The present embodiment goes the preparation method of fat granule elite, comprises the following steps:
(1) first, form by weight and EMT-10 is scattered in glycerine, butanediol, then add corresponding parts by weight Water, allantoin, asiaticosid, wolfberry fruit extract, angelica extract, EDETATE SODIUM and glycine betaine, heating stirring is uniform, must mix Thing a;
(2) the mixture a of step (1) is mixed with olive oil PEG-7 fat, VE, stirred, homogeneous 3-5min must be mixed Thing b;
(3) the mixture b that rapid (2) obtain is cooled to 60-65 DEG C, sequentially add hyaluronic acid, witch hazel, elder, Matrixyl3000, stirring, is uniformly dissolved to obtain mixture c;
(4) when mixture c temperature is down to below 45 DEG C, addMTI, stir to obtain mixture d;
(5) the mixture d that step (4) obtains is cooled to 36 DEG C, and stopping, which is stirred, must remove fat granule elite product.
The embodiment 2-10 constituent and dosage such as following table of going fat granule elite:
The preparation method of fat granule elite is gone described in embodiment 2-10 with embodiment 1.
The performance for going fat granule elite obtained by embodiment 1 is measured:
First, both effectiveness and security
1st, method:Designed using itself cross-reference.
Used after being early later than face cleaning and skin toner daily, take appropriate this product, be applied to eye circumference, with the lifting side that looped above and below the third finger Formula homogeneously kneaded, it is repeated several times to absorption.
2nd, number of cases and the range of age
That includes statistics amounts to 14, and all women, age group is into see the table below.
The range of age Number of cases (people) Ratio (%)
<25 years old 1 7.14
26~35 years old 7 50
36~40 years old 1 7.14
> 41 years old 5 35.72
It is total 14 100
3rd, result of study
(1) adverse events (n=14)
This product has 1 trier slight burning heat sensation occur during testing, can endure.Do not occur other excitants and mistake (being shown in Table 1) occurs for quick situation.
The grease grain eye gel of dispelling of table 1 tries out excitant allergy implementations
This product excitant allergy implementations Number Ratio (%)
Excitant (n=14) 0 0
Anaphylaxis (n=14) 0 0
(2) summary of effects
According to above result on trial, the effective percentage for going fat granule elite to improve fat granules around eyes of the invention is 35.71%, The effective percentage for improving eye circumference wrinkle/microgroove is 78.57%, and the effective percentage for improving pouch is 76.92%.Illustrate that this product fat granule has Certain effect, while have certain crease-resistant and pouch effect of dispelling.The present invention's goes the total effective of fat granule elite moistening effect Rate is 100%, and obvious effective rate 42.86%, moistening effect is relatively good.Viscosity, extensibility, salubrious degree, sticky sense and absorbability etc. Index is also ideal.
The present invention's goes fat granule elite is nonirritant during trying out to occur with anaphylactoid phenomenon, illustrates this product property temperature And have preferable security.
2nd, acute ocular irritation test
Material and method:
1st, tested material:Fat granule elite is gone described in the embodiment of the present invention 1.
2nd, animal:Regular grade rabbit 3, female 1, hero 2.Prosperous experimental animal cultivation Co., Ltd is given birth to by Shanghai to provide, Quality certification number:2007000703283.
3rd, test method
Foundation《Cosmetics safety technical specification》(version in 2015) carries out acute ocular irritation test.
Two eyes of experiment are checked (including fluorescein sodium inspection) in 24h before experiment.
The 0.1ml present invention is taken to go in the conjunctival sac of left eye that fat granule elite is painted into animal, with the opposite side not dealt with Eyes are as own control.According to specification 1 after being painted into the present invention and going fat granule elite, 24,48,72h use handheld slit lamp Scored, and checked in 24h using fluorescein sodium.Stimulate the reaction is not found in 72h, and is terminated on probation.
Scored by table in specification 1, check plot and trial zone are equally handled.And calculating average integral is carried out according to formula, press Table 3 carries out stimulus intensity classification in specification.
Experimental result
Table 2 goes fat granule elite to Rabbits with Acute eye irritation result
Result of the test shows:It is provided by the invention to go fat granule elite to test to be non-stimulated Rabbits with Acute eye irritation Property.
3rd, multiple skin irritation test
Material and method:
1st, tested material:Fat granule elite is gone described in the embodiment of the present invention 1.
2nd, animal:Regular grade rabbit 4, male and female half and half, prosperous experimental animal cultivation Co., Ltd is given birth to by Shanghai and provided, it is qualified Card number:2007000703283.
3rd, test method
Foundation《Cosmetics safety technical specification》(version in 2015) carries out multiple skin irritation test.
Experimental animal back backbone both sides hair is cut before experiment, unhairing scope is respectively 3cm × 3cm, and surface covered is 2.5×2.5cm2
The present invention is taken to go fat granule elite 0.5g to be coated in side on plucked skin, opposite side applies physiological saline conduct Control, smear once daily, it is continuous to smear 14 days.Since second day, cropping before smearing every time, removed and remained with physiological saline Given the test agent.Result is observed after 1 hour, is scored by table in specification 1, check plot and trial zone are equally handled.And entered according to formula Row calculates average integral, and stimulus intensity classification is carried out by table in specification 2.
Result of the test
The present invention of table 3 goes fat granule elite to the multiple skin irritation test result of rabbit
Conclusion (of pressure testing):Other toxicity are had no, it is provided by the invention to go fat granule elite to try the multiple skin irritation of rabbit It is nonirritant to test result.
It should be pointed out that embodiment described above can make those skilled in the art that this hair be more fully understood It is bright, but do not limit the invention in any way.Therefore, it will be appreciated by those skilled in the art that still can be carried out to the present invention Modification or equivalent substitution;And technical scheme and its improvement of all spirit and technical spirit that do not depart from the present invention, it all should Cover among the protection domain of patent of the present invention.

Claims (8)

1. one kind goes fat granule elite, it is characterised in that in parts by weight, the effect of going fat granule elite material composition bag Include:
2. according to claim 1 go fat granule elite, it is characterised in that the effect of going fat granule elite raw material into Dividing includes:
3. according to claim 2 go fat granule elite, it is characterised in that the material composition for going fat granule elite is also Including the one or more in thickener, NMF, stabilizer, skin conditioning agent and preservative.
4. according to claim 3 go fat granule elite, it is characterised in that the thickener is EMT-10, the moisturizing One or more of the agent in glycerine, butanediol, the stabilizer are EDETATE SODIUM, and the skin conditioning agent is selected from beet One or more in alkali, olive oil PEG-7 fat, the preservative areMTI。
5. according to claim 4 go fat granule elite, it is characterised in that in parts by weight, the dosage of each composition is as follows:
6. the preparation method of fat granule elite is gone described in a kind of claim 1-5, it is characterised in that comprise the following steps:
(1) first, form by weight and EMT-10 is scattered in glycerine, butanediol, then add water, the urine of corresponding parts by weight Bursin, asiaticosid, wolfberry fruit extract, angelica extract, EDETATE SODIUM and glycine betaine, heating stirring is uniform, obtains mixture a;
(2) the mixture a of step (1) is mixed with olive oil PEG-7 fat, VE, stirred, homogeneous 3-5min obtains mixture b;
(3) the mixture b that rapid (2) obtain is cooled to 60-65 DEG C, sequentially add hyaluronic acid, witch hazel, elder, Matrixyl 3000, stirring, is uniformly dissolved to obtain mixture c;
(4) the mixture c that step (3) obtains is cooled to 35-38 DEG C, and stopping, which is stirred, must remove fat granule elite product.
7. according to the preparation method described in claim any one of 5-6, it is characterised in that specific steps include:
(1) first, form by weight and EMT-10 is scattered in glycerine, butanediol, then add water, the urine of corresponding parts by weight Bursin, asiaticosid, wolfberry fruit extract, angelica extract, EDETATE SODIUM and glycine betaine, heating stirring is uniform, obtains mixture a;
(2) the mixture a of step (1) is mixed with olive oil PEG-7 fat, VE, stirred, homogeneous 3-5min obtains mixture b;
(3) the mixture b that rapid (2) obtain is cooled to 60-65 DEG C, sequentially add hyaluronic acid, witch hazel, elder, Matrixyl 3000, stirring, is uniformly dissolved to obtain mixture c;
(4) when mixture c temperature is down to below 45 DEG C, addMTI, stir to obtain mixture d;
(5) the mixture d that step (4) obtains is cooled to 35-38 DEG C, and stopping, which is stirred, must remove fat granule elite product.
8. one kind goes fat granule elite by any one of the claim 6-7 preparation methods are preparation-obtained.
CN201711454008.5A 2017-10-18 2017-12-28 Fat-particle-removing essence and preparation method thereof Active CN107875079B (en)

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Application Number Priority Date Filing Date Title
CN201710972756 2017-10-18
CN2017109727566 2017-10-18

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109620777A (en) * 2019-02-13 2019-04-16 樊利平 One kind going fat granule composition and its application

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102319197A (en) * 2011-08-12 2012-01-18 马应龙药业集团股份有限公司 Wrinkle-removal eye paste and preparation method thereof
CN103536489A (en) * 2013-10-18 2014-01-29 桂林雪芙莲日化有限公司 Fat granule-removing eye cream
CN106726917A (en) * 2016-12-15 2017-05-31 广州睿森生物科技有限公司 A kind of eyeware products and solution for lenses and contact lenses

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102319197A (en) * 2011-08-12 2012-01-18 马应龙药业集团股份有限公司 Wrinkle-removal eye paste and preparation method thereof
CN103536489A (en) * 2013-10-18 2014-01-29 桂林雪芙莲日化有限公司 Fat granule-removing eye cream
CN106726917A (en) * 2016-12-15 2017-05-31 广州睿森生物科技有限公司 A kind of eyeware products and solution for lenses and contact lenses

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109620777A (en) * 2019-02-13 2019-04-16 樊利平 One kind going fat granule composition and its application

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