One kind goes fat granule elite and preparation method thereof
Technical field
The present invention relates to field of pharmaceutical preparations, specifically, is related to a kind of prevention fat granule and reduces or eliminates fat granule
Go fat granule elite and preparation method thereof.
Background technology
Fat granule is as produced by endopathic cause and external factor.Endopathic cause is due to body endocrinopathy, causes oil
Fat secretion is superfluous;External factor is excessive use frosted, exfoliating product etc. because skin cleaning does not thoroughly cause pore to block
Cause eye circumference skin atomic small wound occur, the small tumour of white is produced during skin self-regeneration.
The formation of milium has relation with genetic constitution, and it is stayed originating from epidermis or the benign goitre of appendicle epithelium or storage
Property tumour, its profile is similar to calculus, and in yellow-white, about needle point or small rice grain size, the small lump of white can be seen by being needled with pin.When
Skin not enough cleans, and such as uses dense eye shadow color make-up product, or excessive use scrub cream, exfoliating product etc. for a long time, all
Eye circumference skin can be made atomic wound that is small, can not visually discovering occur, and then white is produced during skin self-regeneration
Small tumour --- milium.Dry skin, and the product higher using degree is moistened can be felt by generally occurring within the people of this problem, because
It is misfortune that fat granule elite is invited that this, which can typically take for this,.In fact, the male and children that rare skin care is realized are clinically
And " victim " of common milium.Summing up the reason for forming fat granule mainly includes the following aspects:
1. bad cosmetic custom causes wound:Scrub cream or exfoliating product excessively are used, is easily produced on skin
Small wound, skin is caused to generate the small tumour of white during self-regeneration.
2. fat metabolic disturbance:Skin oil and fat can not be evenly distributed, and cause part to cross Sheng phenomenon, so as to cause eye circumference small
The generation of particle.
3. inappropriate skin care:To avoid wrinkle from occurring too early, many women blindly think quality it is partially oily remove fat granule
Elite can allow skin to become soft, and the fat granule elite of going for hardly realizing oil is difficult to be absorbed by the skin, and unnecessary grease is all accumulated
Pore is blocked in eye circumference, so as to cause short grained appearance.
4. makeup removing is not thorough:Some women are delithted with the dense eye make-up of picture, be often made again during makeup removing not enough carefully, week
Arrive, thus easily cause clogging of pores, so as to induce the short grained generation of eye circumference.
Fat granule (milium) is always the skin disease for perplexing the Ms that likes to be beautiful, and is apt to occur in eyelid and cheek, forehead, because of its generation
There is certain relation using skin care item with inappropriate so that the intelligent that likes to be beautiful is weighed down with anxieties when selecting beauty skin care product, it may be said that
Fat granule (milium) is U.S. eye skin makeup " complication ", " sequelae ".
Fat granule (milium) is the benign goitre or the storage property stayed tumour of epidermis or appendicle epithelium, and some may be with heredity
Constitution is relevant, unsatisfactory using medicine or cosmetic effect merely, even if there is certain effect, will also tend to stimulate instead
Should, but this special onset position of eyelid constrains its use, so clinic is chosen mostly using pin or laser therapy, it is easy
It is easy, get instant result, be still the first choice for solving the problems, such as this skin at present.The product orientation should prevented as can be seen here
Aspect, rather than treatment aspect.It is a to take good care of skin, anti-aging, and without blocking pore, and fat granule can be prevented
Eye gel one solve consumer's trouble and worry, popular favor will necessarily be obtained, market prospects are had an optimistic view of.
The content of the invention
The present invention is directed to the deficiencies in the prior art, it is therefore an objective to and one kind is provided and goes fat granule elite, fat granule essence
Huaan is complete gentle non-stimulated;It and usability is strong, can prevent grease grain from growing, and certain therapeutic action can be reached simultaneously, make oil
Fat granule reduces or disappeared;Furthermore of the invention goes fat granule elite while fat granule effect is gone, using being above also equipped with growing
The characteristics of profit, moisturizing, outward appearance are salubrious, non-greasy.
Another object of the present invention is to be the provision of a kind of preparation method for going fat granule elite, preparation method letter
Single feasible, cost is cheap, is adapted to large-scale production, has broad application prospects.
To achieve these goals, this invention takes following technical measures:
One kind goes fat granule elite, and in parts by weight, the effect of going fat granule elite material composition includes:
Preferably, the effect of going fat granule elite material composition includes:
In addition, the material composition for going fat granule elite also includes thickener, NMF, stabilizer, skin conditioning agent
With the one or more in preservative.
Preferably, the thickener is EMT-10 (hydroxy-ethyl acrylate/sodium acryloyldimethyl taurate copolymers), institute
One or more of the NMF in glycerine, butanediol are stated, the stabilizer is EDETATE SODIUM, and the skin conditioning agent is selected from
One or more, described preservative in glycine betaine, olive oil PEG-7 fat isMTI。
Preferably, in parts by weight, the dosage of each composition is as follows:
And present invention also offers the preparation method that this goes fat granule elite, specifically comprise the following steps:
(1) first, form by weight and EMT-10 is scattered in glycerine, butanediol, then add corresponding parts by weight
Water, allantoin, asiaticosid, wolfberry fruit extract, angelica extract, EDETATE SODIUM and glycine betaine, heating stirring is uniform, must mix
Thing a;
(2) the mixture a of step (1) is mixed with olive oil PEG-7 fat, VE, stirred, homogeneous 3-5min must be mixed
Thing b;
(3) the mixture b that rapid (2) obtain is cooled to 60-65 DEG C, sequentially add hyaluronic acid, witch hazel, elder,
Matrixyl3000, stirring, is uniformly dissolved to obtain mixture c;
(4) the mixture c that step (3) obtains is cooled to 35-38 DEG C, and stopping, which is stirred, must remove fat granule elite product.
Preferably, described preparation method, specific steps include:
(1) first, form by weight and EMT-10 is scattered in glycerine, butanediol, then add corresponding parts by weight
Water, allantoin, asiaticosid, wolfberry fruit extract, angelica extract, EDETATE SODIUM and glycine betaine, heating stirring is uniform, must mix
Thing a;
(2) the mixture a of step (1) is mixed with olive oil PEG-7 fat, VE, stirred, homogeneous 3-5min must be mixed
Thing b;
(3) the mixture b that rapid (2) obtain is cooled to 60-65 DEG C, sequentially add hyaluronic acid, witch hazel, elder,
Matrixyl3000, stirring, is uniformly dissolved to obtain mixture c;
(4) when mixture c temperature is down to below 45 DEG C, addMTI, stir to obtain mixture d;
(5) the mixture d that step (4) obtains is cooled to 35-38 DEG C, and stopping, which is stirred, must remove fat granule elite product.
The present invention compared with prior art, has following following advantage and effect:
(1) present invention for fat granule Producing reason and pathogenesis and creativeness develops rational formula, wherein,
Allantoin promotion organization grows, cell metabolism, cutin-softening layer albumen;Asiaticosid has promotion Wound Healing;Thoroughly
Bright matter acid has good moisture-keeping function;Witch hazel is releived, convergence, the effect of oil-control;REDULITE (elder) is a kind of
Fat-reducing, Firm and traditional fat-splitting agent are to treat the essential new tool of cellulitis;In addition, in basic components
On the basis of, also appropriate increase, which is supported, holds aging ingredient, such as Matrixyl3000 (crease-resistant, anti-aging), vitamin e;The present invention matches somebody with somebody
Side mutually cooperates with, worked in coordination, and causes that the present invention goes fat granule elite to possess excellent to go fat granule effect on the whole;
(2) scientific formula of the present invention is rigorous, effective component analysis is reasonable;Formula safety is gentle non-stimulated;Secondly, the present invention
Product workability is strong, can prevent grease grain from growing, and can reach certain therapeutic action simultaneously, grease grain is reduced or is disappeared;
Furthermore of the invention goes fat granule elite while fat granule effect is gone, using be above also equipped with moistening, moisturizing, outward appearance are salubrious,
The characteristics of non-greasy.
Embodiment:
Technical scheme is described in further detail below in conjunction with specific embodiments.It should be understood that institute
Purpose for embodiment is present disclosure is expanded on further, and can not be construed to protect the present invention in any sense
The limitation of scope.
Embodiment 1:
One kind goes fat granule elite, and in terms of parts by weight, the effect of going fat granule elite material composition includes:
In the present embodiment, EMT-10 matches the product (name of product of BIC Corp (SEPPIC) purchased from France:
SepinovEMT10, product composition:Hydroxy-ethyl acrylate/sodium acryloyldimethyl taurate copolymers).
MTI refers to the iodo- 2-propynyl butyl carbamates of MIT/3-.
The present embodiment goes the preparation method of fat granule elite, comprises the following steps:
(1) first, form by weight and EMT-10 is scattered in glycerine, butanediol, then add corresponding parts by weight
Water, allantoin, asiaticosid, wolfberry fruit extract, angelica extract, EDETATE SODIUM and glycine betaine, heating stirring is uniform, must mix
Thing a;
(2) the mixture a of step (1) is mixed with olive oil PEG-7 fat, VE, stirred, homogeneous 3-5min must be mixed
Thing b;
(3) the mixture b that rapid (2) obtain is cooled to 60-65 DEG C, sequentially add hyaluronic acid, witch hazel, elder,
Matrixyl3000, stirring, is uniformly dissolved to obtain mixture c;
(4) when mixture c temperature is down to below 45 DEG C, addMTI, stir to obtain mixture d;
(5) the mixture d that step (4) obtains is cooled to 36 DEG C, and stopping, which is stirred, must remove fat granule elite product.
The embodiment 2-10 constituent and dosage such as following table of going fat granule elite:
The preparation method of fat granule elite is gone described in embodiment 2-10 with embodiment 1.
The performance for going fat granule elite obtained by embodiment 1 is measured:
First, both effectiveness and security
1st, method:Designed using itself cross-reference.
Used after being early later than face cleaning and skin toner daily, take appropriate this product, be applied to eye circumference, with the lifting side that looped above and below the third finger
Formula homogeneously kneaded, it is repeated several times to absorption.
2nd, number of cases and the range of age
That includes statistics amounts to 14, and all women, age group is into see the table below.
The range of age |
Number of cases (people) |
Ratio (%) |
<25 years old |
1 |
7.14 |
26~35 years old |
7 |
50 |
36~40 years old |
1 |
7.14 |
> 41 years old |
5 |
35.72 |
It is total |
14 |
100 |
3rd, result of study
(1) adverse events (n=14)
This product has 1 trier slight burning heat sensation occur during testing, can endure.Do not occur other excitants and mistake
(being shown in Table 1) occurs for quick situation.
The grease grain eye gel of dispelling of table 1 tries out excitant allergy implementations
This product excitant allergy implementations |
Number |
Ratio (%) |
Excitant (n=14) |
0 |
0 |
Anaphylaxis (n=14) |
0 |
0 |
(2) summary of effects
According to above result on trial, the effective percentage for going fat granule elite to improve fat granules around eyes of the invention is 35.71%,
The effective percentage for improving eye circumference wrinkle/microgroove is 78.57%, and the effective percentage for improving pouch is 76.92%.Illustrate that this product fat granule has
Certain effect, while have certain crease-resistant and pouch effect of dispelling.The present invention's goes the total effective of fat granule elite moistening effect
Rate is 100%, and obvious effective rate 42.86%, moistening effect is relatively good.Viscosity, extensibility, salubrious degree, sticky sense and absorbability etc.
Index is also ideal.
The present invention's goes fat granule elite is nonirritant during trying out to occur with anaphylactoid phenomenon, illustrates this product property temperature
And have preferable security.
2nd, acute ocular irritation test
Material and method:
1st, tested material:Fat granule elite is gone described in the embodiment of the present invention 1.
2nd, animal:Regular grade rabbit 3, female 1, hero 2.Prosperous experimental animal cultivation Co., Ltd is given birth to by Shanghai to provide,
Quality certification number:2007000703283.
3rd, test method
Foundation《Cosmetics safety technical specification》(version in 2015) carries out acute ocular irritation test.
Two eyes of experiment are checked (including fluorescein sodium inspection) in 24h before experiment.
The 0.1ml present invention is taken to go in the conjunctival sac of left eye that fat granule elite is painted into animal, with the opposite side not dealt with
Eyes are as own control.According to specification 1 after being painted into the present invention and going fat granule elite, 24,48,72h use handheld slit lamp
Scored, and checked in 24h using fluorescein sodium.Stimulate the reaction is not found in 72h, and is terminated on probation.
Scored by table in specification 1, check plot and trial zone are equally handled.And calculating average integral is carried out according to formula, press
Table 3 carries out stimulus intensity classification in specification.
Experimental result
Table 2 goes fat granule elite to Rabbits with Acute eye irritation result
Result of the test shows:It is provided by the invention to go fat granule elite to test to be non-stimulated Rabbits with Acute eye irritation
Property.
3rd, multiple skin irritation test
Material and method:
1st, tested material:Fat granule elite is gone described in the embodiment of the present invention 1.
2nd, animal:Regular grade rabbit 4, male and female half and half, prosperous experimental animal cultivation Co., Ltd is given birth to by Shanghai and provided, it is qualified
Card number:2007000703283.
3rd, test method
Foundation《Cosmetics safety technical specification》(version in 2015) carries out multiple skin irritation test.
Experimental animal back backbone both sides hair is cut before experiment, unhairing scope is respectively 3cm × 3cm, and surface covered is
2.5×2.5cm2。
The present invention is taken to go fat granule elite 0.5g to be coated in side on plucked skin, opposite side applies physiological saline conduct
Control, smear once daily, it is continuous to smear 14 days.Since second day, cropping before smearing every time, removed and remained with physiological saline
Given the test agent.Result is observed after 1 hour, is scored by table in specification 1, check plot and trial zone are equally handled.And entered according to formula
Row calculates average integral, and stimulus intensity classification is carried out by table in specification 2.
Result of the test
The present invention of table 3 goes fat granule elite to the multiple skin irritation test result of rabbit
Conclusion (of pressure testing):Other toxicity are had no, it is provided by the invention to go fat granule elite to try the multiple skin irritation of rabbit
It is nonirritant to test result.
It should be pointed out that embodiment described above can make those skilled in the art that this hair be more fully understood
It is bright, but do not limit the invention in any way.Therefore, it will be appreciated by those skilled in the art that still can be carried out to the present invention
Modification or equivalent substitution;And technical scheme and its improvement of all spirit and technical spirit that do not depart from the present invention, it all should
Cover among the protection domain of patent of the present invention.