CN106726917A - A kind of eyeware products and solution for lenses and contact lenses - Google Patents
A kind of eyeware products and solution for lenses and contact lenses Download PDFInfo
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- CN106726917A CN106726917A CN201611162852.6A CN201611162852A CN106726917A CN 106726917 A CN106726917 A CN 106726917A CN 201611162852 A CN201611162852 A CN 201611162852A CN 106726917 A CN106726917 A CN 106726917A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
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Abstract
The invention provides a kind of eyeware products and solution for lenses and contact lenses, including Gotu Kola P.E, purple ball algae extract, corn poppy's extract, NMF, oily matter, surfactant, alcohols material, gel-type vehicle, pH adjusting agent, wetting agent and water.Compared with prior art, functional component in the eyeware products and solution for lenses and contact lenses that the present invention is provided is Gotu Kola P.E, purple ball algae extract and corn poppy's extract, under Gotu Kola P.E, three kinds of synergies of composition of purple ball algae extract and corn poppy's extract, the eyeware products and solution for lenses and contact lenses for providing the present invention can dramatically increase the elasticity of skin, effectively solve the problems, such as the eye skins such as livid ring around eye, pouch, wrinkle, and also the effect with improvement fat granule and edema；Coordinate the other compositions in eyeware products and solution for lenses and contact lenses simultaneously, making the eyeware products and solution for lenses and contact lenses of present invention offer has preferable moistening effect, it is possible to increase eye part skin moisture.
Description
Technical field
The present invention relates to cosmetic technical field, more particularly to a kind of eyeware products and solution for lenses and contact lenses.
Background technology
Eye part skin is the most tender and lovely part of human body skin, is also the position of most fragile, or even smile, these faces of frowning
Expression can all cause eye pouch, crow's feet occur.And, it is the appearance of increasing electronic product, abundant in the modern life
The colorful network life, late into the night overtime work, operating pressure are increased, use the factors such as cosmetics, cosmetics quality problem, aging too early
The eye skin problems such as caused livid ring around eye, canthus line, pouch, edema are further serious.Eye part skin is aging to make a people
Makings is had a greatly reduced quality, and allows people to seem aged wan and sallow, lassitude.Eye skin care with effects such as anti-oxidant, nti-freckle, anti-wrinkle
Product or these symptoms can be mitigated using massage, the injection means such as cosmetics to eye skin.
At present, all kinds of eyeware products and solution for lenses and contact lenses are essentially all the various reasons that basis causes eye skin problem on the market,
Solution is targetedly taken, for example, eye part skin nutrition is supplemented using various nutritive additives, tighten up eye flesh
Skin, makes the temporary elasticity of recovering of eye skin with reduction wrinkle, delay skin aging.Though common eye skin care item add many battalion
Active component is supported, but effect is very undesirable, and nutritional ingredient is deposited on eye part skin, is born to skin tape, causes allergy
Or unnecessary fat granule is produced, and fat granule is eliminated once to produce be difficult in the short time.
The eye skin care item that prior art is provided are difficult to solve the eyes such as livid ring around eye, crow's feet, pouch, microgroove, fat granule
Problem, therefore in order to meet consumer demand, it is badly in need of a kind of safely and effectively eye skin care item of exploitation.
The content of the invention
In view of this, it is an object of the invention to provide a kind of eyeware products and solution for lenses and contact lenses, the eye-care that the present invention is provided is produced
Product can effectively solve the problem that eye part skin problem.
The invention provides a kind of eyeware products and solution for lenses and contact lenses, including Gotu Kola P.E, purple ball algae extract, corn poppy's extraction
Thing, NMF, oil, surfactant, cosurfactant, gel-type vehicle, pH adjusting agent, wetting agent and water.
Preferably, mass content of the Gotu Kola P.E in eyeware products and solution for lenses and contact lenses is 1~6%.
Preferably, mass content of the purple ball algae extract in eyeware products and solution for lenses and contact lenses is 1~5%.
Preferably, mass content of the corn poppy's extract in eyeware products and solution for lenses and contact lenses is 0.5~1.5%.
Preferably, the NMF is selected from acetyl group tetrapeptide -5, ethoxy urea, ceramide, Sodium Hyaluronate, fruit and gathers
One or more in sugar, allantoin, reed fragrant plant oil, D-sorbite and glycine betaine.
Preferably, the grease separation is from olive oil, ethyl oleate, caprylic/capric triglyceride, isopropyl myristate, suddenly
Suddenly bar oil and vitamin E in one or more.
Preferably, the surfactant is selected from Tween-80, Tween-40, Emulsifier EL-60 and soybean lecithin
One or more.
Preferably, the cosurfactant is selected from polyethylene glycol or propane diols.
Preferably, the gel-type vehicle is selected from Carbomer, xanthans, algin, shitosan, Arabic gum or Caesalpinia spinosaKuntze
Glue.
Preferably, the pH adjusting agent is selected from triethanolamine and/or citric acid.
Compared with prior art, the functional component in the eyeware products and solution for lenses and contact lenses that the present invention is provided is Gotu Kola P.E, purple
Ball algae extract and corn poppy's extract, in Gotu Kola P.E, purple three kinds of compositions of ball algae extract and corn poppy's extract
Under synergy, the eyeware products and solution for lenses and contact lenses for providing the present invention can dramatically increase the elasticity of skin, effectively solve livid ring around eye, eye
The eye skin problem such as bag, wrinkle, and also the effect with improvement fat granule and edema；Simultaneously in cooperation eyeware products and solution for lenses and contact lenses
Other compositions, make the present invention offer eyeware products and solution for lenses and contact lenses there is preferable moistening effect, it is possible to increase eye part skin moisture.
Mentioned component is preferably prepared into nano-emulsion gel products by the present invention, compared with Common hydrogels, nano-emulsion gel
Have with skin and preferably couple and hydration effect, good biocompatibility, can long period and site of action tight adhesion, dispersion is equal
It is even, be conducive to fully absorbing for active component, so as to improve its bioavilability.
Specific embodiment
The technical scheme in the embodiment of the present invention will be clearly and completely described below, it is clear that described implementation
Example is only a part of embodiment of the invention, rather than whole embodiments.Based on the embodiment in the present invention, this area is common
The every other embodiment that technical staff is obtained under the premise of creative work is not made, belongs to the model of present invention protection
Enclose.
The invention provides a kind of eyeware products and solution for lenses and contact lenses, including Gotu Kola P.E, purple ball algae extract, corn poppy's extraction
Thing, NMF, oil, surfactant, cosurfactant, gel-type vehicle, pH adjusting agent, wetting agent and water.
In the present invention, there is the Gotu Kola P.E clearing heat and detoxicating, inducing diuresis and reducing edema, nourishing, anti-inflammatory, quelling to make
With, can stimulate deep skin cell substitute；Gotu Kola P.E contains various triterpene compounds, comprising α-amyrin knot
Structure, main component be Asiaticoside, asiatic acid and brahmic acid, additionally containing ursolic acid, cupreol, palmitic acid,
Butanedioic acid, caffeic acid, forulic acid, choline, vitamin C and stachyose, can compact epidermis and corium coupling part, can make skin
Limber up, help to solve cutis laxa phenomenon, make the formation of collagen in the flexible promotion skin corium of skin smooth, make fibre
Fibrillarin regenerates, and skin is reached smooth effect of compacting, and also assists in impaired organization healing and consolidation skin.Centella carries
The close connection that thing can promote between epidermis and corium is taken, the increase of fat cell can be suppressed again, prevented hydroderma, occur
It is fat.The present invention, without special limitation, can be bought by market and obtained to the source of the Gotu Kola P.E.
In the present invention, mass content of the Gotu Kola P.E in eyeware products and solution for lenses and contact lenses is preferably 1~6%, more
Preferably 2~5%, most preferably 3~4%.
In the present invention, the purple ball algae extract contains low oligosaccharide and necessary trace element, can help shrink quiet
Arteries and veins and Dermal microvessel, improve the symptoms such as red blood silk, inflammation, livid ring around eye, oedema, leg be heavy, while promoting Skin Cell again
It is raw, improve skin appearance.The present invention, without special limitation, can be obtained to the source of the purple ball algae extract by market purchase
.
In the present invention, mass content of the purple ball algae extract in eyeware products and solution for lenses and contact lenses is preferably 1~5%, more
Preferably 2~4%, most preferably 3%.
In the present invention, corn poppy's extract spends seed from corn poppy, can be taken off by suppressing glycerol-3-phosphate
The activity of hydrogen enzyme prevents the generation of fat, promotes the release of free fatty, reduces the size of fat cell, decomposes subcutaneous fat
Fat, improves the form and texture of skin surface, reduces " orange peel " phenomenon, prevents pathologic cellulite to be formed.The present invention is to institute
The source of corn poppy's extract is stated without special limitation, can be bought by market and obtained.
In the present invention, mass content of the corn poppy's extract in eyeware products and solution for lenses and contact lenses be preferably 0.5~
1.5%, more preferably 0.8~1.2%, most preferably 1%.
The present invention uses cooperatively Gotu Kola P.E, purple ball algae extract and corn poppy's extract, plays Synergistic
Effect, there is eye haustra -dsipelling, wrinkle, black-eyed good result to eye skin, and edema, fat granule can be effectively improved
Etc. symptom.
In the present invention, the NMF has preferable moisture-keeping function, plays raising eye part skin moisture and lasting lock
The effect of water.In the present invention, the NMF is preferably selected from acetyl group tetrapeptide -5, ethoxy urea, ceramide, hyaluronic acid
One or more in sodium, levulan, allantoin, reed fragrant plant oil, D-sorbite and glycine betaine.The present invention comes to the NMF
Source does not have special limitation, can be bought by market and obtained.In the present invention, quality of the NMF in eyeware products and solution for lenses and contact lenses
Content is preferably 2~7%, more preferably 3~6%, most preferably 4~5%.
In the present invention, to be preferably selected from olive oil, caprylic/capric triglyceride, ethyl oleate, myristic acid different for the oil
One or more in propyl ester, jojoba oil and vitamin E.The present invention to the source of the oil without special limitation, can be by
Market purchase is obtained.In the present invention, mass content of the oil in eyeware products and solution for lenses and contact lenses is preferably 1~4.5%, more preferably
It is 2~4%, most preferably 3%.
In the present invention, the surfactant is preferably selected from Tween-80, Tween-40, Emulsifier EL-60 and soybean
One or more in phosphatide.The present invention, without special limitation, can be obtained to the source of the surfactant by market purchase
.In the present invention, mass content of the surfactant in eyeware products and solution for lenses and contact lenses is preferably 10~25%, more preferably
15~20%, most preferably 18%.
In the present invention, the cosurfactant is preferably selected from polyethylene glycol or propane diols, more preferably polyethylene glycol
400.The present invention, without special limitation, can be bought by market and obtained to the source of the cosurfactant.In the present invention,
Mass content of the cosurfactant in eyeware products and solution for lenses and contact lenses is preferably 5~10%, more preferably 6~9%, most preferably
It is 7~8%.
In the present invention, the gel-type vehicle be preferably selected from Carbomer, xanthans, algin, shitosan, Arabic gum or
Tara gum.The present invention, without special limitation, can be bought by market and obtained to the source of the gel-type vehicle.In the present invention
In, mass content of the gel-type vehicle in eyeware products and solution for lenses and contact lenses is preferably 0.1~0.6%, more preferably 0.2~0.5%,
Most preferably 0.3~0.4%.
In the present invention, the pH adjusting agent is preferably selected from triethanolamine and/or citric acid.The present invention is adjusted to the pH
The source of agent can be bought by market and obtained without special limitation.The present invention does not have special to the consumption of the pH adjusting agent
Limitation, the scope of the pH value of the eyeware products and solution for lenses and contact lenses that the consumption of pH adjusting agent is enabled to 5~7.
In the present invention, the wetting agent is used to soak gel-type vehicle, preferably glycerine.In the present invention, the wetting
Mass content of the agent in eyeware products and solution for lenses and contact lenses is preferably 3~9%, more preferably 4~8%, most preferably 5~7%.
The present invention does not have special limitation, preferably deionized water, people in the art to the species and consumption of the water
Member can be according to the water of actual conditions selection addition Optimum Contents.
Active component in the eyeware products and solution for lenses and contact lenses that the present invention is provided is naturally safe, gentle non-stimulated.
The eyeware products and solution for lenses and contact lenses of mentioned component is preferably prepared into nano-emulsion gel by the present invention using nano-emulsion technology.Nanometer
Breast be spontaneously formed by water, oil, surfactant and cosurfactant etc., it is the Thermodynamically stable that particle diameter is 10~100nm, each
To the same sex, transparent or semitransparent homogeneous dispersion system., easily by biomembrane, percutaneous abilities are good, can be in skin for nano-emulsion
The reservoir of active ingredient is formed, targeting, the effect of sustained release is realized.Nano-emulsion system has advantages below：1) activity can be increased
The solubility of composition；2) bank of active ingredient is quickly formed on skin, and is allowed to, according to gradient penetration rule, be formed by height
To low, passive target effect from outside to inside and sustained-release and controlled release effect reach efficiently release and remarkable result；3) nano-emulsion can be
Prepared under 25 DEG C or so of temperature conditionss, heat labile active component can be protected；4) nano-emulsion also has certain antibacterial action in itself,
Chemical preservative need not be added can just prevent product to go bad；5) nano-emulsion system has relatively low surface tension, it is easy to soak
Skin, makes the structure of cuticula change, thus can promote active component percutaneous absorbtion；6) with traditional emulsion, cream phase
There is comfortableness preferably aesthetic and when using than, nano-emulsion.
Nano-emulsion gel is that the water soluble polymer materials such as gelatin, cellulose, Carbomer, poloxamer are added in nano-emulsion
Material, forms the network structure colloid of transparent stabilization.Nano-emulsion gel can improve the viscosity of nano-emulsion, improve nano-emulsion and skin
The adhesiveness and stretchability of skin.Compared with Common hydrogels, nano-emulsion gel has with skin and preferably couples and hydration effect, raw
Thing compatibility is good, can long period and site of action tight adhesion, be uniformly dispersed, be conducive to fully absorbing for active component, from
And improve its bioavilability.
The eyeware products and solution for lenses and contact lenses of nano-emulsion gel form can solve the problem that common stability, ductility, absorption in cosmetics
Property it is bad the problems such as, and can protection activity composition well activity, be conducive to its rapid osmotic to be absorbed into skin, hair
Wave bioactivity, long-term use.The present invention utilizes nano-emulsion technology in gel, promotes active ingredient to enter skin, from basic
It is upper to solve the problems, such as eye skin.
In the present invention, the preparation method of the eyeware products and solution for lenses and contact lenses is preferably：
Gotu Kola P.E, corn poppy's extract, oil, surfactant and cosurfactant are mixed, is obtained
Oil phase；
Purple ball algae extract, NMF and water are mixed, water phase is obtained；
Water is mutually slowly added into oil phase, mixed liquor is obtained；
Gel-type vehicle and wetting agent are mixed into dispersion, dispersion liquid is obtained；
Mixed liquor is added in dispersion liquid and is stood, it is 5~7 to use pH adjusting agent to adjust pH, obtains final product nano-emulsion gel eye
Portion's care product.
In the present invention, the time of the standing be preferably 10~15 hours, more preferably 12~13 hours.In the present invention
In, the Gotu Kola P.E, purple ball algae extract, corn poppy's extract, NMF, oil, surfactant, help surface-active
The species of agent, gel-type vehicle, pH adjusting agent, wetting agent and water, source and centella extraction described in consumption and above-mentioned technical proposal
Thing, purple ball algae extract, corn poppy's extract, NMF, oil, surfactant, cosurfactant, gel-type vehicle, pH are adjusted
Section agent, wetting agent and the species of water, source are consistent with consumption, will not be repeated here.
Nano-emulsion technology and gel are combined and prepare eyeware products and solution for lenses and contact lenses by the present invention, promote each oil-soluble ingredients and water
Soluble components are solubilized into system well, the state for making the outward appearance of product still transparent, and functional component can quickly by skin
Absorb, the effect with targeting, sustained release.Eyeware products and solution for lenses and contact lenses is prepared into nano-emulsion gel by the present invention can be easy to active ingredient
It is absorbed by the skin, the effect with targeting, sustained release increases skin elasticity, effectively solution with the product for further making present invention offer
The certainly eye skin problem of aging such as livid ring around eye, pouch, wrinkle, and improve fat granule and edema, while having preferable moisturizing to imitate
Really, eye part skin moisture is improved.
The present invention preferably prepares the eyeware products and solution for lenses and contact lenses of nano-emulsion gel state, this eye shield according to the method described above
Reason product has good adhesiveness and stretchability, can for a long time adhere to site of action, is uniformly dispersed, fast beneficial to functional component
Speed is absorbed by eye part skin, and bioavilability is improved, and the effect of functional component is played to greatest extent；Nano-emulsion is in itself
With certain anti-microbial property, make the product of present invention offer without additionally adding chemical preservative, reduce the stimulation to skin；
Nano-emulsion gel products have good solubilising, and oil-soluble and water-soluble active ingredient can be made to be well dissolved in system
In, make product appearance that pellucidity is presented, outward appearance is beautiful；Compared with emulsion of the prior art, cream, nano-emulsion gel quality
Finer and smoother, skin sense is good, thermodynamics, dynamic stabilization, preserve for a long time it is not stratified, without precipitation；And present invention offer
The preparation method of above-mentioned nano-emulsion gel is simple, and energy consumption is low, can complete at room temperature, therefore will not destroy activity in process
The activity of composition.
Raw material used in following examples of the present invention is commercial goods, and Gotu Kola P.E is bought in Guangzhou rising sun sail trade
Easy Co., Ltd；Purple ball algae extract, corn poppy's extract are bought in the Hao Bo Co., Ltds of Guangzhou hundred.
Embodiment 1
The composition of eyeware products and solution for lenses and contact lenses is：
Gotu Kola P.E 1wt%, purple ball algae extract 3wt%, corn poppy's extract 1.5wt%, acetyl group tetrapeptide -5
2wt%, isopropyl myristate 1wt%, Emulsifier EL-60 10wt%, PEG400 5wt%, algin
0.6wt%, glycerine 9wt%, triethanolamine 0.8wt%, balance of water.
The preparation method of eyeware products and solution for lenses and contact lenses is：
By Gotu Kola P.E, corn poppy's extract, isopropyl myristate, Emulsifier EL-60 and polyethylene glycol
400 be stirred at room temperature it is well mixed as oil phase；Purple ball algae extract, acetyl group tetrapeptide -5 and water are stirred at room temperature mixed
Close uniform, as water phase；Then water is mutually added slowly in oil phase while stirring, is stirred to clarify transparent；Algin is added
In glycerine soak, be uniformly dispersed, be subsequently adding above-mentioned clear transparent solutions, place 12h after stirring, fully it is swelling after, plus
Enter triethanolamine, obtain final product nano-emulsion gel products.
Embodiment 2
The composition of eyeware products and solution for lenses and contact lenses is：
Gotu Kola P.E 3.5wt%, purple ball algae extract 1wt%, corn poppy's extract 0.5wt%, ethoxy urea
1wt%, Cer EOS .5wt%, Sodium Hyaluronate 3wt%, olive oil 2wt%, ethyl oleate 0.5wt%, Tween-80
5wt%, soybean lecithin 10wt%, PEG400 7wt%, tara gum 0.2wt%, glycerine 6wt%, citric acid
0.3wt%, balance of water.
The preparation method of eyeware products and solution for lenses and contact lenses is：
By Gotu Kola P.E, corn poppy's extract, olive oil, ethyl oleate, Tween-80, soybean lecithin and poly- second two
Alcohol 400 is stirred at room temperature well mixed as oil phase；By purple ball algae extract, ethoxy urea, ceramide, Sodium Hyaluronate
Be stirred at room temperature with water it is well mixed, as water phase；Then water is mutually added slowly in oil phase while stirring, is stirred to clarify
It is transparent；Soaked during tara gum is added into glycerine, be uniformly dispersed, be subsequently adding above-mentioned clear transparent solutions, put after stirring
Put 12h, fully it is swelling after, add citric acid, obtain final product nano-emulsion gel products.
Embodiment 3
The composition of eyeware products and solution for lenses and contact lenses is：
Gotu Kola P.E 6wt%, purple ball algae extract 2wt%, corn poppy's extract 1wt%, reed fragrant plant oil 5wt%, fruit
Glycan 2wt%, jojoba oil 2wt%, vitamin E 1.5wt%, caprylic/capric triglyceride 1wt%, Tween-40
10wt%, Emulsifier EL-60 15wt%, propane diols 10wt%, Carbomer 0.1wt%, glycerine 3wt%, triethanolamine
0.2wt%, balance of water.
The preparation method of eyeware products and solution for lenses and contact lenses is：
By Gotu Kola P.E, corn poppy's extract, jojoba oil, vitamin E, caprylic/capric triglyceride, tween-
40th, Emulsifier EL-60 and propane diols are stirred at room temperature well mixed as oil phase；By purple ball algae extract, reed fragrant plant oil,
Levulan and water be stirred at room temperature it is well mixed, as water phase；Then water is mutually added slowly in oil phase while stirring, is stirred
To clear；Soaked during Carbomer is added into glycerine, be uniformly dispersed, be subsequently adding above-mentioned clear transparent solutions, stirred
After place 12h, fully it is swelling after, add triethanolamine, obtain final product nano-emulsion gel products.
Embodiment 4
The composition of eyeware products and solution for lenses and contact lenses is：
Gotu Kola P.E 4wt%, purple ball algae extract 5wt%, corn poppy's extract 0.5wt%, D-sorbite
2wt%, glycine betaine 4wt%, olive oil 1.5wt%, vitamin E 2wt%, Emulsifier EL-60 8wt%, soybean lecithin
12wt%, propane diols 8wt%, xanthans 0.3wt%, glycerine 6wt%, triethanolamine 0.4wt%, citric acid 0.2wt%, surplus
It is water.
The preparation method of eyeware products and solution for lenses and contact lenses is：
By Gotu Kola P.E, corn poppy's extract, olive oil, vitamin E, soybean lecithin, Emulsifier EL-60 and
Propane diols is stirred at room temperature well mixed as oil phase；By purple ball algae extract, D-sorbite, glycine betaine and water at room temperature
It is uniformly mixed, as water phase；Then water is mutually added slowly in oil phase while stirring, is stirred to clarify transparent；By xanthan
Glue is soaked in adding glycerine, is uniformly dispersed, and is subsequently adding above-mentioned clear transparent solutions, and 12h is placed after stirring, fully swelling
Afterwards, citric acid is added, nano-emulsion gel products are obtained final product.
Embodiment 5
The composition of eyeware products and solution for lenses and contact lenses is：
Gotu Kola P.E 3wt%, purple ball algae extract 4wt%, corn poppy's extract 0.8wt%, acetyl group tetrapeptide -5
2wt%, Cer NP wt%, IPM 2wt%, jojoba oil 2wt%, Tween-80 7wt%, soybean lecithin
10wt%, propane diols 6wt%, tara gum 0.4wt%, glycerine 7wt%, citric acid 0.3wt%, balance of water.
The preparation method of eyeware products and solution for lenses and contact lenses is：
By Gotu Kola P.E, corn poppy's extract, IPM, jojoba oil, soybean lecithin, Tween-80 and
Propane diols is stirred at room temperature well mixed as oil phase；Purple ball algae extract, acetyl group tetrapeptide -5, ceramide and water are existed
It is uniformly mixed at room temperature, as water phase；Then water is mutually added slowly in oil phase while stirring, is stirred to clarify transparent；
Soaked during tara gum is added into glycerine, be uniformly dispersed, be subsequently adding above-mentioned clear transparent solutions, 12h is placed after stirring,
Fully it is swelling after, add citric acid, obtain final product nano-emulsion gel products.
Embodiment 6
The composition of eyeware products and solution for lenses and contact lenses is：
Gotu Kola P.E 6wt%, purple ball algae extract 2wt%, corn poppy's extract 1wt%, reed fragrant plant oil 5wt%, fruit
Glycan 2wt%, Carbomer 0.1wt%, glycerine 3wt%, triethanolamine 0.2wt%, balance of water.
The preparation method of eyeware products and solution for lenses and contact lenses is：
Carbomer is added to the water, 85 DEG C are heated to, clear is evenly stirred until；Then lower the temperature, treat that temperature is down to 45
DEG C when, addition the reed fragrant plant oil, levulan, the glycerine that are pre-mixed stir；Triethanolamine is slowly dropped into, pH to 6 is adjusted；
Gotu Kola P.E, purple ball algae extract and corn poppy's extract are finally sequentially added, stirring is completely dissolved it, obtains eye
Care product.
Comparative example 1
The composition and preparation method of eyeware products and solution for lenses and contact lenses are same as Example 6, and difference is to be added without purple ball algae to extract
Thing and corn poppy's extract, and the addition of Gotu Kola P.E is 9wt%.
Comparative example 2
The composition and preparation method of eyeware products and solution for lenses and contact lenses are same as Example 6, and difference is to be added without centella extraction
Thing and corn poppy's extract, and the addition of purple ball algae extract is 9wt%.
Comparative example 3
The composition and preparation method of eyeware products and solution for lenses and contact lenses are same as Example 6, and difference is to be added without centella extraction
Thing and purple ball algae extract, and the addition of corn poppy's extract is 9wt%.
Embodiment 7
Steady testing is carried out to the eyeware products and solution for lenses and contact lenses that the embodiment of the present invention 1~6 and comparative example 1~3 are prepared
1) centrifugal test：Appropriate product is weighed in centrifuge tube, 4000rpm centrifugation 30min observe cosmetic variation.
2) low temperature resistant test：Appropriate product is taken, is placed in measuring cup and is sealed, be put into -20 DEG C of refrigerators, sampled within every 7 days, continuously
Investigate 3 months, observe cosmetic variation.
3) heat resistant test：Appropriate product is taken, is placed in measuring cup and is sealed, be put into 60 DEG C of baking ovens, sampling observation in every 7 days,
It is continuous to investigate 3 months, observe cosmetic variation.
Testing result is that nano-emulsion gel prepared by embodiment 1~5 is not stratified through centrifugation, high temperature, low-temperature test, outward
Sight does not all change.There is precipitation after centrifugation in product prepared by embodiment 6 and comparative example 1~3, in -20 DEG C of environment
After placing 1 month, there is floccule, the clarification that outward appearance is not started to yet is bright, after being placed 1 month in 60 DEG C of environment, outward appearance
It is thick white shape colloid.
Embodiment 8
Product Safety is evaluated：Human skin patch
30 ages of selection are the subject without skin disease allergies between 25-50 Sui.Patch method：From qualified
Spot tries device, and with closed patch experiment method, the embodiment of the present invention 1~6 and comparative example 1~3 for taking about 0.020~0.025g are made
Standby product is dripped in spot examination device, and external application special adhesive tape is covered on subject back, and each subject pastes 9 spot examination devices, respectively
Product prepared by patch examination embodiment 1~6 and comparative example 1~3, removes product after 24 hours, after removal respectively at 0.5,6,12,
24th, observation dermoreaction in 48 hours, according to《Cosmetics health specification》Middle dermoreaction grade scale records its result.
Result of the test is：The patch test that human skin patch result display each group subject passes through each set product,
Dermoreaction was observed at 0.5,6,12,24,48 hours, wherein 0 skin adverse reaction occurs, the product of present invention offer is illustrated
It is non-stimulated using safety.
Embodiment 9
Livid ring around eye and fat granule improvement are tested：
The fat granule of selection 180 25-50 Sui and the serious experimenter of livid ring around eye, are randomly divided into 9 groups, and implementation is used respectively
Eyeware products and solution for lenses and contact lenses prepared by example 1~6 and comparative example 1~3, application method is：After cleaning face, the product for taking grain of rice size is applied
Smear to eye surrounding, flicking absorbs, it is daily respectively to use once sooner or later, adhere to using 1 month.Specific effect is as shown in table 1,
Table 1 is eyeware products and solution for lenses and contact lenses provided in an embodiment of the present invention to livid ring around eye and the improvement of fat granule.
The eyeware products and solution for lenses and contact lenses provided in an embodiment of the present invention of table 1 is to livid ring around eye and the improvement of fat granule
As shown in Table 1, compared to embodiment 6, the eyeware products and solution for lenses and contact lenses that embodiment 1~5 is provided has to livid ring around eye and fat granule
There is the improvement for becoming apparent, this explanation is better than mill run using the improvement of nanogel product.Embodiment 6
Effect is better than comparative example 1~3, and the content of the active component in comparative example 1~3 is identical with the content of active component in embodiment 6,
But its effect is poor, illustrate that Gotu Kola P.E, purple ball algae extract, corn poppy's extract have synergy.
Embodiment 10
Moisture-keeping efficacy is tested：
Choose health volunteer, the age at 25-50 Sui, test site room temperature (25 ± 1) DEG C, relative humidity (40 ±
5) %, it is desirable to which tester shifts to an earlier date 30min and enters test environment.Marked on the inside of tester's left and right arm tested person region (3cm ×
3cm), same arm can simultaneously mark multiple regions (interval 1cm), and test sample is randomly dispersed in left and right arm.First survey
The blank value of each test zone is tried, then test specimens press (2.0 ± 0.1) mg/cm2Consumption carry out single smearing, adopted after smearing
With Multi-functional skin moisture tester and moisture of skin scatter and disappear instrument measure 1 respectively, 2, the tested regions of 4h and blank region
Skin moisture content and through transepidermal water windage (TEWL), according to parallel determination 5 times, blank region is in each region
Any sample is not smeared.Eyeware products and solution for lenses and contact lenses prepared by the embodiment of the present invention 1~6 and comparative example 1~3 is entered according to such scheme
Row moisture-keeping efficacy is tested, and as a result as shown in table 2 and table 3, table 2 is the skin moisture content (%) of different time (h), and table 3 is not for
Same time (h) through transepidermal water windage (%).
The skin moisture content (%) of the different time (h) of table 2
The different time (h) of table 3 through transepidermal water windage (%)
| Test specimens | 0 | 1 | 2 | 4 |
| Blank control group | 15.59 | 15.83 | 15.16 | 15.79 |
| Embodiment 1 | 15.70 | 13.16 | 11.95 | 12.18 |
| Embodiment 2 | 15.47 | 12.73 | 11.58 | 11.24 |
| Embodiment 3 | 15.65 | 12.07 | 11.49 | 10.58 |
| Embodiment 4 | 15.50 | 12.34 | 11.62 | 10.91 |
| Embodiment 5 | 15.49 | 12.95 | 11.73 | 11.57 |
| Embodiment 6 | 15.62 | 13.90 | 13.51 | 12.83 |
| Comparative example 1 | 15.41 | 13.64 | 13.07 | 12.59 |
| Comparative example 2 | 15.53 | 13.72 | 13.25 | 12.67 |
| Comparative example 3 | 15.68 | 13.62 | 12.93 | 12.55 |
From table 2 and table 3, compared with embodiment 6 and comparative example 1~3, the guarantor of the eyeware products and solution for lenses and contact lenses of embodiment 1~5
It is wet better, skin water content can be significantly improved, make the lasting water lock of skin, with good moisture-keeping efficacy.
Embodiment 11
Skin elasticity is tested
180 women are chosen, the age between 25-50 Sui, is randomly divided into 9 groups, after cleaning face, takes the sheet of grain of rice size
Eyeware products and solution for lenses and contact lenses prepared by inventive embodiments 1~6 and comparative example 1~3 is applied to eye surrounding, and flicking absorbs, daily
Sooner or later it is each using once, using skin elasticity tester, test respectively the 1st, 2,4 weeks skin elasticity index R2 in tested region,
R5, R7 (it is 450mbar that negative pressure is constant in test process), take user's test result average value.After tested region clean
The skin elasticity index of 30min is initial value.Index explanation：Skin elasticity index R2, R5, R7 illustrates the bullet of skin closer to 1
Property is better.Shown in 4~table of result of the test table 12.
Product skin elasticity index prepared by 4 embodiment of table 1
| Test period | R2 | R5 | R7 |
| 0 | 0.5022 | 0.4713 | 0.4205 |
| 1 | 0.6673 | 0.6381 | 0.5603 |
| 2 | 0.7863 | 0.7605 | 0.6954 |
| 4 | 0.9057 | 0.8830 | 0.8463 |
Product skin elasticity index prepared by 5 embodiment of table 2
| Test period | R2 | R5 | R7 |
| 0 | 0.4822 | 0.4613 | 0.4483 |
| 1 | 0.6242 | 0.6301 | 0.5822 |
| 2 | 0.7654 | 0.7505 | 0.7209 |
| 4 | 0.9114 | 0.8830 | 0.8753 |
Product skin elasticity index prepared by 6 embodiment of table 3
| Test period | R2 | R5 | R7 |
| 0 | 0.4507 | 0.4791 | 0.4172 |
| 1 | 0.6181 | 0.6273 | 0.5607 |
| 2 | 0.7529 | 0.7732 | 0.7047 |
| 4 | 0.9045 | 0.9137 | 0.8507 |
Product skin elasticity index prepared by 7 embodiment of table 4
| Test period | R2 | R5 | R7 |
| 0 | 0.5017 | 0.4802 | 0.4397 |
| 1 | 0.6704 | 0.6410 | 0.6034 |
| 2 | 0.8292 | 0.8024 | 0.7503 |
| 4 | 0.9477 | 0.9236 | 0.8852 |
Product skin elasticity index prepared by 8 embodiment of table 5
| Test period | R2 | R5 | R7 |
| 0 | 0.4792 | 0.4835 | 0.4029 |
| 1 | 0.6307 | 0.6438 | 0.5527 |
| 2 | 0.7731 | 0.7920 | 0.7014 |
| 4 | 0.9053 | 0.9127 | 0.8552 |
Product skin elasticity index prepared by 9 embodiment of table 6
| Test period | R2 | R5 | R7 |
| 0 | 0.4953 | 0.4811 | 0.4027 |
| 1 | 0.6215 | 0.6394 | 0.5315 |
| 2 | 0.7103 | 0.7517 | 0.6339 |
| 4 | 0.8205 | 0.8351 | 0.7535 |
Product skin elasticity index prepared by 10 comparative example of table 1
| Test period | R2 | R5 | R7 |
| 0 | 0.4815 | 0.4796 | 0.4258 |
| 1 | 0.5733 | 0.5804 | 0.5071 |
| 2 | 0.6529 | 0.6925 | 0.5932 |
| 4 | 0.7483 | 0.7741 | 0.7049 |
Product skin elasticity index prepared by 11 comparative example of table 2
| Test period | R2 | R5 | R7 |
| 0 | 0.4619 | 0.4750 | 0.4227 |
| 1 | 0.5481 | 0.5692 | 0.4961 |
| 2 | 0.6167 | 0.6409 | 0.5719 |
| 4 | 0.6835 | 0.7214 | 0.6472 |
Product skin elasticity index prepared by 12 comparative example of table 3
Known by table 4~12, compared with embodiment 6 and comparative example 1~3, the eye-care prepared using embodiment 1~5
After product 4 weeks, the skin elasticity index lifting of recipient site is more notable, closer to 1, the effect that wherein embodiment 6 is presented
It is better than comparative example 1~3 again.This says that the effect of the nanogel eyeware products and solution for lenses and contact lenses of present invention preparation is substantially better than mill run,
And Gotu Kola P.E, purple ball algae extract, 3 kinds of extracts of corn poppy's extract have synergy, product effect is better than single
Solely include a kind of product of extract.Therefore, eyeware products and solution for lenses and contact lenses of the invention can effectively solve the eye skin of wrinkle, pouch
Problem.
As seen from the above embodiment, the invention provides a kind of eyeware products and solution for lenses and contact lenses, including Gotu Kola P.E, purple ball algae
Extract, corn poppy's extract, NMF, oil, surfactant, cosurfactant, gel-type vehicle, pH adjusting agent, wetting
Agent and water.Compared with prior art, the functional component in the eyeware products and solution for lenses and contact lenses that the present invention is provided is Gotu Kola P.E, purple ball
Algae extract and corn poppy's extract, in Gotu Kola P.E, purple three kinds of associations of composition of ball algae extract and corn poppy's extract
Under same-action, making the eyeware products and solution for lenses and contact lenses of present invention offer can dramatically increase the elasticity of skin, effectively solve livid ring around eye, pouch,
The eye skin problem such as wrinkle, and also the effect with improvement fat granule and edema；Simultaneously in cooperation eyeware products and solution for lenses and contact lenses
Other compositions, making the eyeware products and solution for lenses and contact lenses of present invention offer has preferable moistening effect, it is possible to increase eye part skin moisture.
Mentioned component is preferably prepared into nano-emulsion gel products by the present invention, compared with Common hydrogels, nano-emulsion gel
Have with skin and preferably couple and hydration effect, good biocompatibility, can long period and site of action tight adhesion, dispersion is equal
It is even, be conducive to fully absorbing for active component, so as to improve its bioavilability.
Claims (10)
1. a kind of eyeware products and solution for lenses and contact lenses, including Gotu Kola P.E, purple ball algae extract, corn poppy's extract, NMF, oil,
Surfactant, cosurfactant, gel-type vehicle, pH adjusting agent, wetting agent and water.
2. eyeware products and solution for lenses and contact lenses according to claim 1, it is characterised in that the Gotu Kola P.E is produced in eye-care
Mass content in product is 1~6%.
3. eyeware products and solution for lenses and contact lenses according to claim 1, it is characterised in that the purple ball algae extract is produced in eye-care
Mass content in product is 1~5%.
4. eyeware products and solution for lenses and contact lenses according to claim 1, it is characterised in that corn poppy's extract is produced in eye-care
Mass content in product is 0.5~1.5%.
5. eyeware products and solution for lenses and contact lenses according to claim 1, it is characterised in that the NMF be selected from acetyl group tetrapeptide -5,
One kind in ethoxy urea, ceramide, Sodium Hyaluronate, levulan, allantoin, reed fragrant plant oil, D-sorbite and glycine betaine or
It is several.
6. eyeware products and solution for lenses and contact lenses according to claim 1, it is characterised in that the grease separation is from olive oil, ethyl oleate, pungent
One or more in acid/Triglyceride DDD, isopropyl myristate, jojoba oil and vitamin E.
7. eyeware products and solution for lenses and contact lenses according to claim 1, it is characterised in that the surfactant is selected from Tween-80, tells
One or more in temperature -40, Emulsifier EL-60 and soybean lecithin.
8. eyeware products and solution for lenses and contact lenses according to claim 1, it is characterised in that the cosurfactant is selected from polyethylene glycol
Or propane diols.
9. eyeware products and solution for lenses and contact lenses according to claim 1, it is characterised in that the gel-type vehicle is selected from Carbomer, xanthan
Glue, algin, shitosan, Arabic gum or tara gum.
10. eyeware products and solution for lenses and contact lenses according to claim 1, it is characterised in that the pH adjusting agent be selected from triethanolamine and/
Or citric acid.
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