CN111658557A - Nano-structure liposome capable of eliminating eye bags immediately and preparation method and application thereof - Google Patents
Nano-structure liposome capable of eliminating eye bags immediately and preparation method and application thereof Download PDFInfo
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- CN111658557A CN111658557A CN202010575515.XA CN202010575515A CN111658557A CN 111658557 A CN111658557 A CN 111658557A CN 202010575515 A CN202010575515 A CN 202010575515A CN 111658557 A CN111658557 A CN 111658557A
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- 239000002502 liposome Substances 0.000 title claims abstract description 45
- 239000002086 nanomaterial Substances 0.000 title claims abstract description 29
- 238000002360 preparation method Methods 0.000 title description 17
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 43
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims abstract description 42
- 230000001153 anti-wrinkle effect Effects 0.000 claims abstract description 32
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 29
- SEBFKMXJBCUCAI-UHFFFAOYSA-N NSC 227190 Natural products C1=C(O)C(OC)=CC(C2C(OC3=CC=C(C=C3O2)C2C(C(=O)C3=C(O)C=C(O)C=C3O2)O)CO)=C1 SEBFKMXJBCUCAI-UHFFFAOYSA-N 0.000 claims abstract description 24
- SEBFKMXJBCUCAI-HKTJVKLFSA-N silibinin Chemical compound C1=C(O)C(OC)=CC([C@@H]2[C@H](OC3=CC=C(C=C3O2)[C@@H]2[C@H](C(=O)C3=C(O)C=C(O)C=C3O2)O)CO)=C1 SEBFKMXJBCUCAI-HKTJVKLFSA-N 0.000 claims abstract description 24
- 229960004245 silymarin Drugs 0.000 claims abstract description 24
- 235000017700 silymarin Nutrition 0.000 claims abstract description 24
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 claims abstract description 23
- 229940042585 tocopherol acetate Drugs 0.000 claims abstract description 23
- QZLXCFQVOCEKSX-NOCHOARKSA-N (2s,4r)-1-hexadecanoyl-4-hexadecanoyloxypyrrolidine-2-carboxylic acid Chemical compound CCCCCCCCCCCCCCCC(=O)O[C@@H]1C[C@@H](C(O)=O)N(C(=O)CCCCCCCCCCCCCCC)C1 QZLXCFQVOCEKSX-NOCHOARKSA-N 0.000 claims abstract description 22
- SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 claims abstract description 22
- 239000007957 coemulsifier Substances 0.000 claims abstract description 22
- 229930002330 retinoic acid Natural products 0.000 claims abstract description 22
- 229960001727 tretinoin Drugs 0.000 claims abstract description 22
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims abstract description 21
- 235000012000 cholesterol Nutrition 0.000 claims abstract description 21
- 239000008367 deionised water Substances 0.000 claims abstract description 21
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 21
- 239000000787 lecithin Substances 0.000 claims abstract description 21
- 229940067606 lecithin Drugs 0.000 claims abstract description 21
- 235000010445 lecithin Nutrition 0.000 claims abstract description 21
- 239000004480 active ingredient Substances 0.000 claims abstract description 17
- 241000628997 Flos Species 0.000 claims abstract description 10
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 69
- YPFDHNVEDLHUCE-UHFFFAOYSA-N propane-1,3-diol Chemical compound OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 claims description 46
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 25
- SNAAJJQQZSMGQD-UHFFFAOYSA-N aluminum magnesium Chemical compound [Mg].[Al] SNAAJJQQZSMGQD-UHFFFAOYSA-N 0.000 claims description 22
- 229940107161 cholesterol Drugs 0.000 claims description 18
- 238000010438 heat treatment Methods 0.000 claims description 18
- 239000003921 oil Substances 0.000 claims description 15
- 235000019198 oils Nutrition 0.000 claims description 15
- 238000002156 mixing Methods 0.000 claims description 14
- 240000004674 Papaver rhoeas Species 0.000 claims description 12
- 235000007846 Papaver rhoeas Nutrition 0.000 claims description 12
- 238000004945 emulsification Methods 0.000 claims description 9
- 239000000839 emulsion Substances 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 9
- 229940049964 oleate Drugs 0.000 claims description 8
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims description 8
- FFNOWYSCJOKVCL-UHFFFAOYSA-N 1-hydroxy-3,3-dimethylbutan-2-one Chemical compound CC(C)(C)C(=O)CO FFNOWYSCJOKVCL-UHFFFAOYSA-N 0.000 claims description 7
- 240000003549 Brabejum stellatifolium Species 0.000 claims description 7
- 235000013698 Brabejum stellatifolium Nutrition 0.000 claims description 7
- 239000005909 Kieselgur Substances 0.000 claims description 7
- IYFATESGLOUGBX-YVNJGZBMSA-N Sorbitan monopalmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O IYFATESGLOUGBX-YVNJGZBMSA-N 0.000 claims description 7
- 239000008168 almond oil Substances 0.000 claims description 7
- 150000002148 esters Chemical class 0.000 claims description 7
- ZUVCYFMOHFTGDM-UHFFFAOYSA-N hexadecyl dihydrogen phosphate Chemical compound CCCCCCCCCCCCCCCCOP(O)(O)=O ZUVCYFMOHFTGDM-UHFFFAOYSA-N 0.000 claims description 7
- 150000002632 lipids Chemical class 0.000 claims description 7
- 239000000203 mixture Substances 0.000 claims description 7
- 229950003429 sorbitan palmitate Drugs 0.000 claims description 7
- 239000002537 cosmetic Substances 0.000 claims description 3
- 230000000694 effects Effects 0.000 abstract description 17
- 206010030113 Oedema Diseases 0.000 abstract description 7
- 230000007774 longterm Effects 0.000 abstract description 5
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 abstract description 4
- 230000037303 wrinkles Effects 0.000 abstract description 4
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 abstract description 2
- 229960003471 retinol Drugs 0.000 abstract description 2
- 235000020944 retinol Nutrition 0.000 abstract description 2
- 239000011607 retinol Substances 0.000 abstract description 2
- 235000008753 Papaver somniferum Nutrition 0.000 abstract 1
- 240000001090 Papaver somniferum Species 0.000 abstract 1
- 230000000052 comparative effect Effects 0.000 description 20
- 238000000265 homogenisation Methods 0.000 description 19
- 210000003022 colostrum Anatomy 0.000 description 6
- 235000021277 colostrum Nutrition 0.000 description 6
- 210000000744 eyelid Anatomy 0.000 description 4
- 229910052919 magnesium silicate Inorganic materials 0.000 description 4
- 235000019792 magnesium silicate Nutrition 0.000 description 4
- 239000000391 magnesium silicate Substances 0.000 description 4
- 230000003796 beauty Effects 0.000 description 3
- NEMFQSKAPLGFIP-UHFFFAOYSA-N magnesiosodium Chemical compound [Na].[Mg] NEMFQSKAPLGFIP-UHFFFAOYSA-N 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- CPLXHLVBOLITMK-UHFFFAOYSA-N Magnesium oxide Chemical compound [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 230000001804 emulsifying effect Effects 0.000 description 2
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 2
- 230000003340 mental effect Effects 0.000 description 2
- 229910001415 sodium ion Inorganic materials 0.000 description 2
- 230000035882 stress Effects 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- JLVVSXFLKOJNIY-UHFFFAOYSA-N Magnesium ion Chemical compound [Mg+2] JLVVSXFLKOJNIY-UHFFFAOYSA-N 0.000 description 1
- NWGKJDSIEKMTRX-AAZCQSIUSA-N Sorbitan monooleate Chemical group CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O NWGKJDSIEKMTRX-AAZCQSIUSA-N 0.000 description 1
- OBNDGIHQAIXEAO-UHFFFAOYSA-N [O].[Si] Chemical compound [O].[Si] OBNDGIHQAIXEAO-UHFFFAOYSA-N 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- DNEHKUCSURWDGO-UHFFFAOYSA-N aluminum sodium Chemical compound [Na].[Al] DNEHKUCSURWDGO-UHFFFAOYSA-N 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 201000010251 cutis laxa Diseases 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- POULHZVOKOAJMA-UHFFFAOYSA-M dodecanoate Chemical compound CCCCCCCCCCCC([O-])=O POULHZVOKOAJMA-UHFFFAOYSA-M 0.000 description 1
- 210000004709 eyebrow Anatomy 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229960000890 hydrocortisone Drugs 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 229940070765 laurate Drugs 0.000 description 1
- 229910001425 magnesium ion Inorganic materials 0.000 description 1
- HCWCAKKEBCNQJP-UHFFFAOYSA-N magnesium orthosilicate Chemical compound [Mg+2].[Mg+2].[O-][Si]([O-])([O-])[O-] HCWCAKKEBCNQJP-UHFFFAOYSA-N 0.000 description 1
- 230000004089 microcirculation Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 230000000474 nursing effect Effects 0.000 description 1
- 210000004279 orbit Anatomy 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- PJGSXYOJTGTZAV-UHFFFAOYSA-N pinacolone Chemical compound CC(=O)C(C)(C)C PJGSXYOJTGTZAV-UHFFFAOYSA-N 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 229910052604 silicate mineral Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 229950004959 sorbitan oleate Drugs 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000037072 sun protection Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 230000037331 wrinkle reduction Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/14—Liposomes; Vesicles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/56—Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Emergency Medicine (AREA)
- Biotechnology (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
Abstract
The invention relates to a nano-structure liposome for instantly eliminating pouches, which comprises the following components in parts by weight: 5-25 parts of a firming anti-wrinkle active ingredient, 10.4-74.5 parts of nano vesicles and 5-78 parts of deionized water, wherein the firming anti-wrinkle active ingredient comprises the following components in parts by weight: 0.1-8 parts of hydroxyppinacolone retinoic acid, 3-70 parts of flos poppy extract, 2-33 parts of dipalmitoyl hydroxyproline and 5-35 parts of silymarin, wherein the nano vesicle comprises the following components in parts by weight: 3-30 parts of emulsifier, 1-40 parts of co-emulsifier, 2-50 parts of tocopherol acetate, 0.1-6 parts of cholesterol and 0.1-7 parts of lecithin. The invention utilizes the nano-structure liposome technology to physically cover various true and edema type bags under the eyes so as to achieve the effect of removing false impression of the bags under the eyes in time; the nano-structure liposome of the invention wraps retinol, tocopherol acetate and the like with very good anti-wrinkle activity, and can achieve good effects of resisting wrinkles and compacting eye skin after long-term use.
Description
Technical Field
The invention relates to a nano-structure liposome for instantly eliminating pouches and a preparation method and application thereof, belonging to the technical field of cosmetics.
Background
10000 parts of 'consumer eye nursing habit questionnaire' result shows that 63% of consumers indicate that eye bags can cause canthus drooping, eyes become small and the color value is influenced. And compared with the high cost of micro-plastic and relieving means such as object beauty, eye exercises and the like, people with more than 8 layers prefer to use eye cream or eye essence to solve the problem of eye skin. Therefore, the development of an eye care product for removing the eye bags in time has wide requirements and application prospects.
The bags are generally divided into two types, true bags and edema bags. Among them, the true pouch is also called eyelid skin laxity, which generally refers to the laxity of skin occurring in the lower eyelid (or in the upper eyelid). In the lower eyelid, due to the progressive increase in age, collagen decreases and fat relaxes, resulting in a decrease in tension between the skin and the ocular septum, so that the intraorbital fat, tissue, pushes the ocular septum out through the orbital septal weak link, which over time becomes what we generally refer to as an eye pouch. This pouch is often caused by ultraviolet rays and aging, and it is intended to be prevented reasonably, but only by the sun protection and the use of antioxidant and anti-aging products for early prevention. This "real pouch" is common in the elderly, aged forty and older, and is essentially inherited if it is a young girl. For the 'true eye bags', the common skin care products do not provide much help, and if the beauty is really influenced, only the medical beauty is helped.
The edema type eye bags are most commonly encountered by many people, for example, yesterday does not sleep well in the evening, gets up in the morning to find that eyes of people are swollen, and meanwhile, deep eye bags exist. Although this condition is only temporary and will slowly disappear after a few hours, the formation of "pockets" does affect the aesthetic appearance of the face because some body fluids remain in the tissues surrounding the eye sockets when lying down for sleep, and excessive mental stress causes our body to secrete additional hormones (such as cortisol). The factors which can cause edema type eye bags are not only staying up all night but also mental stress and the like.
At present, the instant pouch-removing products all use some raw materials for promoting microcirculation to solve the edema type pouch. Therefore, there is a need to develop a pouch removing product, which can be used for various true and edema type pouches and can achieve good effects of resisting wrinkles and tightening eye skin after long-term use.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provide the nano-structure liposome for eliminating the pouch in real time and the preparation method and application thereof.
In order to achieve the purpose, the invention adopts the technical scheme that: a nano-structure liposome for instantly eliminating pouches comprises the following components in parts by weight: 5-25 parts of tightening anti-wrinkle active component, 10.4-74.5 parts of nano vesicle and 5-78 parts of deionized water,
the firming and anti-wrinkle active ingredient comprises the following components in parts by weight: 0.1-8 parts of hydroxyppinacolone retinoic acid, 3-70 parts of flos Papaveris extract, 2-33 parts of dipalmitoyl hydroxyproline, 5-35 parts of silymarin,
the nano vesicle comprises the following components in parts by weight: 3-30 parts of emulsifier, 1-40 parts of co-emulsifier, 2-50 parts of tocopherol acetate, 0.1-6 parts of cholesterol and 0.1-7 parts of lecithin.
Sodium magnesium silicate is a layered silicate mineral formed by the periodic arrangement of silicon-oxygen tetrahedra and magnesium-oxygen octahedra in the Z-axis direction in a ratio of 2: 1. In the magnesium silicate sodium trioctahedral structure, a part of magnesium ions in magnesium-oxygen octahedrons are replaced by sodium ions, so that crystal layers are negatively charged, and exchangeable sodium ions exist between adjacent platelets to balance the negative charges, so that the whole crystal is neutral. When the nano-structure liposome is added into the nano-structure liposome, the emulsifying capacity and stability of an emulsifier can be improved, and the adhesion of diatomite can be improved.
As a preferred embodiment of the nanostructured liposome of the present invention, the nanostructured liposome comprises the following components in parts by weight: 18 parts of tightening anti-wrinkle active component, 45 parts of nano vesicle and 37 parts of deionized water,
the firming and anti-wrinkle active ingredient comprises the following components in parts by weight: 3 parts of hydroxyppinacolone retinoic acid, 55 parts of corn poppy extract, 18 parts of dipalmitoyl hydroxyproline and 24 parts of silymarin,
the nano vesicle comprises the following components in parts by weight: 18 parts of emulsifier, 30 parts of co-emulsifier, 45 parts of tocopherol acetate, 4 parts of cholesterol and 3 parts of lecithin.
As a preferred embodiment of the nanostructured liposome of the present invention, the emulsifier comprises the following components in parts by weight: 5 parts of polyglycerol-10 oleate, 10 parts of sorbitan palmitate, 7 parts of cetyl phosphate and 10 parts of wild almond oil polyglycerol-6 ester.
As a preferred embodiment of the nanostructured liposome of the present invention, the coemulsifier comprises the following components in parts by weight: 2-15 parts of magnesium aluminum silicate, 3-16 parts of diatomite, 5-50 parts of glycerol and 5-50 parts of 1, 3-propylene glycol.
As a preferred embodiment of the nanostructured liposome of the present invention, the coemulsifier comprises the following components in parts by weight: 12 parts of magnesium aluminum silicate, 14 parts of diatomite, 35 parts of glycerol and 37 parts of 1, 3-propylene glycol.
In a second aspect, the present invention provides a method for preparing the above nanostructured liposome, comprising the following steps:
(1) mixing emulsifier, magnesium aluminum silicate, diatomaceous earth, tocopherol acetate, cholesterol, lecithin, hydroxy pinacolone retinoic acid and silymarin uniformly, and heating until the mixture is completely dissolved and dispersed to obtain an oil phase;
(2) mixing glycerol, 1, 3-propylene glycol, flos Papaveris Rhoeadis extract, dipalmitoyl hydroxyproline and deionized water, and heating to dissolve and disperse uniformly to obtain water soluble component;
(3) slowly adding the water-soluble component obtained in the step (2) into the oil phase obtained in the step (1) for primary emulsification to obtain primary emulsion;
(4) and (4) homogenizing the primary emulsion obtained in the step (3) under high pressure to obtain the nanostructured lipid carrier.
As a preferable embodiment of the preparation method of the present invention, in the step (1), the heating temperature is 55 to 75 ℃; in the step (2), the heating temperature is 45-55 ℃.
As a preferred embodiment of the preparation method of the present invention, in the step (3), the rotation speed of the initial emulsification is 5000-10000 r/min.
As a preferred embodiment of the preparation method of the present invention, in the step (4), the homogenization pressure is 800-1200bar, the homogenization time is 5-9 times, and the homogenization time is 1-6 min.
In a third aspect, the invention provides the application of the nanostructure liposome in cosmetics.
Compared with the prior art, the invention has the beneficial effects that:
(1) according to the invention, sodium magnesium silicate is selected as an auxiliary emulsifier, and the emulsifying capacity of the emulsifier and the adhesive capacity of diatomite are enhanced by utilizing the trioctahedral structure of the sodium magnesium silicate, so that the nano-structure liposome can be immediately filmed and stable after being coated, and is not easy to immediately whiten and rub mud; the invention utilizes the adsorption and adhesion capacities of sodium aluminum silicate and diatomite to wrap active substances in the structure of the silymarin, thereby slowing down the irritation of the hydroxy pinacoline retinoic acid and simultaneously solving the problems of insolubility of silymarin in water and oil and difficult application.
(2) The invention utilizes the nano-structure liposome technology to physically cover various true and edema type bags under the eyes so as to achieve the effect of removing false impression of the bags under the eyes in time; the nano-structure liposome of the invention wraps retinol, tocopherol acetate and the like with very good anti-wrinkle activity, and can achieve good effects of resisting wrinkles and compacting eye skin after long-term use.
Detailed Description
To better illustrate the objects, aspects and advantages of the present invention, the present invention will be further described with reference to specific examples.
Example 1
A nano-structure liposome comprises the following components in parts by weight: 18 parts of tightening anti-wrinkle active component, 45 parts of nano vesicle and 37 parts of deionized water,
the firming and anti-wrinkle active ingredient comprises the following components in parts by weight: 3 parts of hydroxyppinacolone retinoic acid, 55 parts of corn poppy extract, 18 parts of dipalmitoyl hydroxyproline and 24 parts of silymarin,
the nano vesicle comprises the following components in parts by weight: 18 parts of emulsifier, 30 parts of co-emulsifier, 45 parts of tocopherol acetate, 4 parts of cholesterol and 3 parts of lecithin.
The emulsifier comprises the following components in parts by weight: 5 parts of polyglycerol-10 oleate, 10 parts of sorbitan palmitate, 7 parts of cetyl phosphate and 10 parts of polyglycerol-6 ester of wild almond oil;
the auxiliary emulsifier comprises the following components in parts by weight: 12 parts of magnesium aluminum silicate, 14 parts of diatomite, 35 parts of glycerol and 37 parts of 1, 3-propylene glycol.
The preparation method of the nanostructure liposome comprises the following steps:
(1) mixing emulsifier, magnesium aluminum silicate, diatomaceous earth, tocopherol acetate, cholesterol, lecithin, hydroxy pinacolone retinoic acid and silymarin uniformly, heating to 65 ℃, and dissolving and dispersing the mixture completely to obtain an oil phase;
(2) mixing glycerol, 1, 3-propylene glycol, flos Papaveris Rhoeadis extract, dipalmitoyl hydroxyproline and deionized water, heating to 50 deg.C, dissolving and dispersing uniformly to obtain water soluble component;
(3) slowly adding the water-soluble component obtained in the step (2) into the oil phase obtained in the step (1) for primary emulsification for 2min under the condition of 8000r/min to obtain primary emulsion;
(4) and (4) carrying out high-pressure homogenization on the colostrum obtained in the step (3) under the conditions of pressure of 950bar, homogenization times of 7 times and homogenization time of 4min to obtain the nanostructured lipid carrier.
Example 2
A nano-structure liposome for instantly eliminating pouches comprises the following components in parts by weight: 18 parts of tightening anti-wrinkle active component, 45 parts of nano vesicle and 37 parts of deionized water,
the firming and anti-wrinkle active ingredient comprises the following components in parts by weight: 5 parts of hydroxyppinacolone retinoic acid, 55 parts of corn poppy extract, 20 parts of dipalmitoyl hydroxyproline and 20 parts of silymarin,
the nano vesicle comprises the following components in parts by weight: 18 parts of emulsifier, 30 parts of co-emulsifier, 45 parts of tocopherol acetate, 4 parts of cholesterol and 3 parts of lecithin.
The emulsifier comprises the following components in parts by weight: 5 parts of polyglycerol-10 oleate, 10 parts of sorbitan palmitate, 7 parts of cetyl phosphate and 10 parts of polyglycerol-6 ester of wild almond oil;
the auxiliary emulsifier comprises the following components in parts by weight: 12 parts of magnesium aluminum silicate, 14 parts of diatomite, 35 parts of glycerol and 37 parts of 1, 3-propylene glycol.
The preparation method of the nanostructure liposome comprises the following steps:
(1) mixing emulsifier, magnesium aluminum silicate, diatomaceous earth, tocopherol acetate, cholesterol, lecithin, hydroxy pinacolone retinoic acid and silymarin uniformly, heating to 65 ℃, and dissolving and dispersing the mixture completely to obtain an oil phase;
(2) mixing glycerol, 1, 3-propylene glycol, flos Papaveris Rhoeadis extract, dipalmitoyl hydroxyproline and deionized water, heating to 50 deg.C, dissolving and dispersing uniformly to obtain water soluble component;
(3) slowly adding the water-soluble component obtained in the step (2) into the oil phase obtained in the step (1) for primary emulsification for 3min under the condition of 10000r/min to obtain primary emulsion;
(4) and (4) carrying out high-pressure homogenization on the colostrum obtained in the step (3) under the conditions of 1200bar of pressure, 8 times of homogenization and 4min of homogenization time to obtain the nanostructured lipid carrier.
Example 3
A nano-structure liposome for instantly eliminating pouches comprises the following components in parts by weight: 5 parts of tightening anti-wrinkle active component, 25 parts of nano vesicle and 70 parts of deionized water,
the firming and anti-wrinkle active ingredient comprises the following components in parts by weight: 3 parts of hydroxyppinacolone retinoic acid, 55 parts of corn poppy extract, 18 parts of dipalmitoyl hydroxyproline and 24 parts of silymarin,
the nano vesicle comprises the following components in parts by weight: 18 parts of emulsifier, 30 parts of co-emulsifier, 45 parts of tocopherol acetate, 4 parts of cholesterol and 3 parts of lecithin.
The emulsifier comprises the following components in parts by weight: 5 parts of polyglycerol-10 oleate, 10 parts of sorbitan palmitate, 7 parts of cetyl phosphate and 10 parts of polyglycerol-6 ester of wild almond oil;
the auxiliary emulsifier comprises the following components in parts by weight: 12 parts of magnesium aluminum silicate, 14 parts of diatomite, 35 parts of glycerol and 37 parts of 1, 3-propylene glycol.
The preparation method of the nanostructure liposome comprises the following steps:
(1) mixing emulsifier, magnesium aluminum silicate, diatomaceous earth, tocopherol acetate, cholesterol, lecithin, hydroxy pinacolone retinoic acid and silymarin uniformly, heating to 65 ℃, and dissolving and dispersing the mixture completely to obtain an oil phase;
(2) mixing glycerol, 1, 3-propylene glycol, flos Papaveris Rhoeadis extract, dipalmitoyl hydroxyproline and deionized water, heating to 50 deg.C, dissolving and dispersing uniformly to obtain water soluble component;
(3) slowly adding the water-soluble component obtained in the step (2) into the oil phase obtained in the step (1) for primary emulsification for 2min under the condition of 8000r/min to obtain primary emulsion;
(4) and (4) carrying out high-pressure homogenization on the colostrum obtained in the step (3) under the conditions of 1200bar of pressure, 5 times of homogenization and 3min of homogenization time to obtain the nanostructured lipid carrier.
Example 4
A nano-structure liposome for instantly eliminating pouches comprises the following components in parts by weight: 25 parts of tightening anti-wrinkle active component, 70 parts of nano vesicle and 5 parts of deionized water,
the firming and anti-wrinkle active ingredient comprises the following components in parts by weight: 3 parts of hydroxyppinacolone retinoic acid, 55 parts of corn poppy extract, 18 parts of dipalmitoyl hydroxyproline and 24 parts of silymarin;
the nano vesicle comprises the following components in parts by weight: 18 parts of emulsifier, 30 parts of co-emulsifier, 45 parts of tocopherol acetate, 4 parts of cholesterol and 3 parts of lecithin;
the emulsifier comprises the following components in parts by weight: 5 parts of polyglycerol-10 oleate, 10 parts of sorbitan palmitate, 7 parts of cetyl phosphate and 10 parts of polyglycerol-6 ester of wild almond oil;
the auxiliary emulsifier comprises the following components in parts by weight: 12 parts of magnesium aluminum silicate, 14 parts of diatomite, 35 parts of glycerol and 37 parts of 1, 3-propylene glycol.
The preparation method of the nanostructure liposome comprises the following steps:
(1) mixing emulsifier, magnesium aluminum silicate, diatomaceous earth, tocopherol acetate, cholesterol, lecithin, hydroxy pinacolone retinoic acid and silymarin uniformly, heating to 65 ℃, and dissolving and dispersing the mixture completely to obtain an oil phase;
(2) mixing glycerol, 1, 3-propylene glycol, flos Papaveris Rhoeadis extract, dipalmitoyl hydroxyproline and deionized water, heating to 50 deg.C, dissolving and dispersing uniformly to obtain water soluble component;
(3) slowly adding the water-soluble component obtained in the step (2) into the oil phase obtained in the step (1) for primary emulsification for 2min under the condition of 8000r/min to obtain primary emulsion;
(4) and (4) carrying out high-pressure homogenization on the colostrum obtained in the step (3) under the conditions of pressure of 950bar, homogenization times of 7 times and homogenization time of 4min to obtain the nanostructured lipid carrier.
Example 5
A nano-structure liposome for instantly eliminating pouches comprises the following components in parts by weight: 18 parts of tightening anti-wrinkle active component, 45 parts of nano vesicle and 37 parts of deionized water,
the firming and anti-wrinkle active ingredient comprises the following components in parts by weight: 3 parts of hydroxyppinacolone retinoic acid, 55 parts of corn poppy extract, 18 parts of dipalmitoyl hydroxyproline and 24 parts of silymarin,
the nano vesicle comprises the following components in parts by weight: 18 parts of emulsifier, 30 parts of co-emulsifier, 45 parts of tocopherol acetate, 4 parts of cholesterol and 3 parts of lecithin.
The emulsifier comprises the following components in parts by weight: 5 parts of polyglycerol-10 oleate, 10 parts of sorbitan palmitate, 7 parts of cetyl phosphate and 10 parts of polyglycerol-6 ester of wild almond oil;
the auxiliary emulsifier comprises the following components in parts by weight: 2 parts of magnesium aluminum silicate, 16 parts of diatomite, 32 parts of glycerol and 50 parts of 1, 3-propylene glycol.
The preparation method of the nanostructure liposome comprises the following steps:
(1) mixing emulsifier, magnesium aluminum silicate, diatomaceous earth, tocopherol acetate, cholesterol, lecithin, hydroxy pinacolone retinoic acid and silymarin uniformly, heating to 65 ℃, and dissolving and dispersing the mixture completely to obtain an oil phase;
(2) mixing glycerol, 1, 3-propylene glycol, flos Papaveris Rhoeadis extract, dipalmitoyl hydroxyproline and deionized water, heating to 50 deg.C, dissolving and dispersing uniformly to obtain water soluble component;
(3) slowly adding the water-soluble component obtained in the step (2) into the oil phase obtained in the step (1) for primary emulsification for 2min under the condition of 8000r/min to obtain primary emulsion;
(4) and (4) carrying out high-pressure homogenization on the colostrum obtained in the step (3) under the conditions of pressure of 950bar, homogenization times of 7 times and homogenization time of 4min to obtain the nanostructured lipid carrier.
Example 6
A nano-structure liposome for instantly eliminating pouches comprises the following components in parts by weight: 11.6 parts of tightening anti-wrinkle active component, 10.4 parts of nano vesicle and 78 parts of deionized water,
the firming and anti-wrinkle active ingredient comprises the following components in parts by weight: 0.1 part of hydroxyppinacolone retinoic acid, 70 parts of corn poppy flower extract, 2 parts of dipalmitoyl hydroxyproline and 27.9 parts of silymarin,
the nano vesicle comprises the following components in parts by weight: 3 parts of emulsifier, 40 parts of co-emulsifier, 44 parts of tocopherol acetate, 6 parts of cholesterol and 7 parts of lecithin.
The emulsifier is polyglycerol-10 oleate; the auxiliary emulsifier comprises the following components in parts by weight: 15 parts of magnesium aluminum silicate, 3 parts of diatomite, 50 parts of glycerol and 32 parts of 1,3 propylene glycol.
The preparation method of this example is the same as example 1.
Example 7
A nano-structure liposome for instantly eliminating pouches comprises the following components in parts by weight: 15 parts of tightening anti-wrinkle active component, 74.5 parts of nano vesicle, 10.5 parts of deionized water,
the firming and anti-wrinkle active ingredient comprises the following components in parts by weight: 8 parts of hydroxyppinacolone retinoic acid, 24 parts of corn poppy extract, 33 parts of dipalmitoyl hydroxyproline and 35 parts of silymarin,
the nano vesicle comprises the following components in parts by weight: 30 parts of emulsifier, 19.8 parts of co-emulsifier, 50 parts of tocopherol acetate, 0.1 part of cholesterol and 0.1 part of lecithin.
The emulsifier is polyglycerol-10 laurate; the auxiliary emulsifier comprises the following components in parts by weight: 15 parts of magnesium aluminum silicate, 16 parts of diatomite, 5 parts of glycerol and 50 parts of 1, 3-propylene glycol.
The preparation method of this example is the same as example 1.
Example 8
A nano-structure liposome for instantly eliminating pouches comprises the following components in parts by weight: 18 parts of tightening anti-wrinkle active component, 45 parts of nano vesicle and 37 parts of deionized water,
the firming and anti-wrinkle active ingredient comprises the following components in parts by weight: 8 parts of hydroxyppinacolone retinoic acid, 3 parts of corn poppy extract, 33 parts of dipalmitoyl hydroxyproline and 5 parts of silymarin,
the nano vesicle comprises the following components in parts by weight: 30 parts of emulsifier, 1 part of co-emulsifier, 2 parts of tocopherol acetate, 6 parts of cholesterol and 7 parts of lecithin.
The emulsifier is sorbitan oleate; the auxiliary emulsifier comprises the following components in parts by weight: 15 parts of magnesium aluminum silicate, 16 parts of diatomite, 50 parts of glycerol and 5 parts of 1, 3-propylene glycol.
The preparation method of this example is the same as example 1.
Comparative example 1
Compared with the example 1, the anti-wrinkle active ingredients for removing the firming effect are as follows: 58 parts of corn poppy flower extract, 18 parts of dipalmitoyl hydroxyproline and 24 parts of silymarin; the rest of the process was the same as in example 1.
Comparative example 2
Compared with example 1, the coemulsifiers are: 20 parts of diatomite, 30 parts of glycerol and 50 parts of 1, 3-propylene glycol; the rest of the process was the same as in example 1.
Comparative example 3
Compared with example 1, the coemulsifiers are: 20 parts of magnesium aluminum silicate, 30 parts of glycerol and 50 parts of 1, 3-propylene glycol; the rest of the process was the same as in example 1.
Comparative example 4
Compared with the example 1, the auxiliary emulsifier is as follows: 1 part of magnesium aluminum silicate, 20 parts of diatomite, 39 parts of glycerol and 40 parts of 1, 3-propylene glycol; the others are consistent with the embodiments.
Comparative example 5
Compared with the example 1, the colostrum obtained in the preparation step is the product without high-pressure homogenization.
Examples of effects
Test subjects: 650 patients with different degrees of bags were selected, half of men and women, aged 35-55 years, and randomly divided into 13 groups of 50 patients each.
Test products: examples 1 to 8 and comparative examples 1 to 5 were applied to each group.
The using method comprises the following steps: thoroughly cleaning facial skin, lightly applying the product on eyebrow and under eyes with ring finger, massaging eyes back and forth with index finger, taking pictures before and after use with VISA, and taking pictures before and after the first application; long-term effect: the product is applied 2 times every morning and evening, and the effects are compared after face washing 56 days.
And (3) evaluating the efficacy: remove the eye bag immediately, it is effective: the pouch is immediately hidden and ineffective: the pouch is not pulled and still exists; the pouch is improved for a long time, and the effect is as follows: pouch improvement (not completely eliminated), wrinkle reduction, no effect: the eye bags are unchanged and even more serious, and the wrinkles are not lightened or even deepened.
The results of the test for the immediate pouch removal effect of examples 1 to 8 and comparative examples 1 to 5 are shown in table 1, and the results of the test for the long-acting pouch removal effect are shown in table 2.
TABLE 1
| Serial number | Sample(s) | Effective/example | Invalid/example | Effective rate% |
| Example 1 | 50 | 48 | 2 | 96 |
| Example 2 | 50 | 44 | 6 | 88 |
| Example 3 | 50 | 40 | 10 | 80 |
| Example 4 | 50 | 42 | 8 | 84 |
| Example 5 | 50 | 45 | 5 | 90 |
| Example 6 | 50 | 39 | 7 | 78 |
| Example 7 | 50 | 35 | 6 | 70 |
| Example 8 | 50 | 36 | 10 | 72 |
| Comparative example 1 | 50 | 10 | 40 | 20 |
| Comparative example 2 | 50 | 0 | 50 | 0 |
| Comparative example 3 | 50 | 0 | 50 | 0 |
| Comparative example 4 | 50 | 9 | 41 | 18 |
| Comparative example 5 | 50 | 8 | 42 | 16 |
TABLE 2
| Serial number | Sample(s) | Effective/example | Invalid/example | Effective rate% |
| Example 1 | 50 | 49 | 2 | 98 |
| Example 2 | 50 | 45 | 5 | 90 |
| Example 3 | 50 | 44 | 6 | 92 |
| Example 4 | 50 | 46 | 4 | 92 |
| Example 5 | 50 | 45 | 5 | 90 |
| Example 6 | 50 | 38 | 8 | 76 |
| Example 7 | 50 | 34 | 7 | 38 |
| Example 8 | 50 | 35 | 12 | 70 |
| Comparative example 1 | 50 | 5 | 45 | 20 |
| Comparative example 2 | 50 | 1 | 49 | 2 |
| Comparative example 3 | 50 | 1 | 49 | 2 |
| Comparative example 4 | 50 | 3 | 47 | 6 |
| Comparative example 5 | 50 | 4 | 46 | 8 |
As can be seen from table 1, the nanostructured liposome of the present invention has good immediate and long-term pouch removal effects. Comparative examples 1 to 3 do not completely contain all the components of the present invention, comparative example 4 does not completely contain the co-emulsifier, and comparative example 5 is different from the present invention in the preparation method and does not have the pouch removing effect. And, in the nanostructured liposome of the present invention, the nanostructured liposome comprises the following components in parts by weight: the anti-wrinkle fabric comprises 18 parts of a tightening anti-wrinkle active ingredient, 45 parts of nano vesicles and 37 parts of deionized water, wherein the tightening anti-wrinkle active ingredient comprises the following components in parts by weight: 3 parts of hydroxyppinacolone retinoic acid, 55 parts of corn poppy extract, 18 parts of dipalmitoyl hydroxyproline and 24 parts of silymarin, wherein the nano vesicle comprises the following components in parts by weight: 18 parts of emulsifier, 30 parts of co-emulsifier, 45 parts of tocopherol acetate, 4 parts of cholesterol and 3 parts of lecithin, wherein the co-emulsifier comprises the following components in parts by weight: 12 parts of magnesium aluminum silicate, 14 parts of diatomite, 35 parts of glycerol and 37 parts of 1, 3-propylene glycol, the prepared nano-structure liposome has the best effect of removing eye bags.
Finally, it should be noted that the above embodiments are only used for illustrating the technical solutions of the present invention and not for limiting the protection scope of the present invention, and although the present invention is described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions can be made on the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention.
Claims (10)
1. The nano-structure liposome for instantly eliminating the pouch is characterized by comprising the following components in parts by weight: 5-25 parts of tightening anti-wrinkle active component, 10.4-74.5 parts of nano vesicle and 5-78 parts of deionized water,
the firming and anti-wrinkle active ingredient comprises the following components in parts by weight: 0.1-8 parts of hydroxyppinacolone retinoic acid, 3-70 parts of flos Papaveris extract, 2-33 parts of dipalmitoyl hydroxyproline, 5-35 parts of silymarin,
the nano vesicle comprises the following components in parts by weight: 3-30 parts of emulsifier, 1-40 parts of co-emulsifier, 2-50 parts of tocopherol acetate, 0.1-6 parts of cholesterol and 0.1-7 parts of lecithin.
2. The nanostructured liposome of claim 1, wherein the nanostructured liposome comprises the following components in parts by weight: 18 parts of tightening anti-wrinkle active component, 45 parts of nano vesicle and 37 parts of deionized water,
the firming and anti-wrinkle active ingredient comprises the following components in parts by weight: 3 parts of hydroxyppinacolone retinoic acid, 55 parts of corn poppy extract, 18 parts of dipalmitoyl hydroxyproline and 24 parts of silymarin,
the nano vesicle comprises the following components in parts by weight: 18 parts of emulsifier, 30 parts of co-emulsifier, 45 parts of tocopherol acetate, 4 parts of cholesterol and 3 parts of lecithin.
3. The nanostructured liposome according to claim 1 or 2, wherein the emulsifier comprises the following components in parts by weight: 5 parts of polyglycerol-10 oleate, 10 parts of sorbitan palmitate, 7 parts of cetyl phosphate and 10 parts of wild almond oil polyglycerol-6 ester.
4. The nanostructured liposome according to claim 1 or 2, wherein the coemulsifier comprises the following components in parts by weight: 2-15 parts of magnesium aluminum silicate, 3-16 parts of diatomite, 5-50 parts of glycerol and 5-50 parts of 1, 3-propylene glycol.
5. The nanostructured liposome according to claim 4, wherein the coemulsifier comprises the following components in parts by weight: 12 parts of magnesium aluminum silicate, 14 parts of diatomite, 35 parts of glycerol and 37 parts of 1, 3-propylene glycol.
6. The method of preparing a nanostructured liposome according to any one of claims 1 to 5, comprising the steps of:
(1) mixing emulsifier, magnesium aluminum silicate, diatomaceous earth, tocopherol acetate, cholesterol, lecithin, hydroxy pinacolone retinoic acid and silymarin uniformly, and heating until the mixture is completely dissolved and dispersed to obtain an oil phase;
(2) mixing glycerol, 1, 3-propylene glycol, flos Papaveris Rhoeadis extract, dipalmitoyl hydroxyproline and deionized water, and heating to dissolve and disperse uniformly to obtain water soluble component;
(3) slowly adding the water-soluble component obtained in the step (2) into the oil phase obtained in the step (1) for primary emulsification to obtain primary emulsion;
(4) and (4) homogenizing the primary emulsion obtained in the step (3) under high pressure to obtain the nanostructured lipid carrier.
7. The method according to claim 6, wherein in the step (1), the heating temperature is 55 to 75 ℃; in the step (2), the heating temperature is 45-55 ℃.
8. The method as set forth in claim 6, wherein in the step (3), the rotation speed of the initial emulsification is 5000-10000 r/min.
9. The method as set forth in claim 6, wherein in the step (4), the homogenizing pressure is 800-1200bar, the homogenizing time is 5-9 times, and the homogenizing time is 1-6 min.
10. Use of a nanostructured liposome according to any of claims 1 to 5 in cosmetics.
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Application publication date: 20200915 |