CN111012682A - Slimming nano liposome and preparation method and application thereof - Google Patents
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Abstract
The invention discloses a slimming nano liposome and a preparation method thereof, belonging to the technical field of special cosmetics. The slimming nano liposome comprises the following components in parts by weight: 0.10-30.00 parts of slimming functional components, 1.00-10.00 parts of phospholipid, 0.10-5.00 parts of sterol, 1.00-10.00 parts of emulsifier, 2.00-30.00 parts of polyalcohol and the balance of water to 100 parts. The invention loads the slimming functional components which can directly or indirectly promote lipolysis, inhibit adipocyte differentiation, inhibit the uptake of free fatty acid in the adipocyte and the synthesis of triglyceride and promote skin microcirculation, thereby reducing the number and the volume of the adipocyte and inhibiting and eliminating fat accumulation into the nanoliposome with the grain diameter of 10-500nm, and has the characteristics of good stability, high safety (no hormone), targeted slow release, synergistic effect, good transdermal absorption, long retention time, high bioavailability and the like, thereby having ideal slimming effect.
Description
Technical Field
The invention belongs to the field of efficacy cosmetics, and particularly relates to a slimming nano liposome and a preparation method thereof.
Background
With the continuous improvement of the living standard of people, the obese people are more and more. The fundamental reason for obesity is that the intake of energy exceeds the consumption of energy, and when a person eats more calories than consumed, the excess calories are stored in the body in the form of fat, and when a certain amount is reached, the person becomes obese. Obesity not only affects the beauty and mental health of obese people, but also can cause various diseases, such as hypertension, hyperlipidemia, arteriosclerosis, fatty liver, diabetes, myocardial infarction, and the like.
Aiming at obese people, slimming products with different concepts appear on the market, such as medicine weight reduction (appetite suppression, energy consumption increase, intestinal digestion and absorption inhibition and the like), exercise weight reduction, tea drinking weight reduction, external application of a traditional Chinese medicine bag for weight reduction, acupoint pressing weight reduction, diet weight reduction and the like. The above weight-reducing methods have different effects, some of them will rebound or have certain side effects, so it is worried that long-term use can cause endocrine dysfunction and damage the functions of heart, liver, kidney and other organs. Therefore, the research and development of products with good slimming effect, safety and health are great tendency, and the product has good market prospect.
With the continuous development of the cosmetic market in China, some slimming cosmetics gradually appear on the market. Because the weight-reducing cosmetics are convenient to use, the weight-reducing cosmetics are very popular with some consumers. However, consumers are confused about the mixing of the weight-reducing cosmetics, namely the fish dragon, and some merchants have been reluctant to add medicines, hormones and the like to the weight-reducing products. Although some effect may be obtained when consumers use the slimming cosmetics, endocrine disturbance may be caused and the risk of disease may be increased after long-term use.
Theoretically, through transdermal absorption, some pharmaceutical or cosmetic raw materials can directly or indirectly promote lipolysis, inhibit differentiation of fat cells, inhibit the uptake of free fatty acids and synthesis of triglyceride in the fat cells, and promote skin microcirculation, thereby reducing the number and volume of the fat cells, inhibiting and eliminating fat accumulation and achieving the purpose of slimming. However, it is difficult for these drugs or cosmetic materials to actually pass through the thick epidermis or dermis due to the barrier action of the skin, and act on the underlying adipose tissue.
The traditional slimming cosmetics are prepared by adding some functional plant extracts into a micron emulsification system or water, so that the extracts are easy to lose activity due to the change of external environment (illumination, oxygen, temperature, pH value and the like), and even if the stable functional plant extracts are difficult to penetrate through thick epidermis and dermis to act on the fat tissue below the thick epidermis and the dermis, the due slimming effect is difficult to achieve.
Therefore, the improvement of the safety, stability and permeability of the slimming functional components is a difficult problem to be solved urgently for realizing the efficacy of the slimming functional cosmetics.
Disclosure of Invention
The purpose of the invention is as follows: the invention aims to make up the defects of the existing slimming cosmetic research technology, and provides a slimming nano liposome which can simultaneously encapsulate water-soluble and oil-soluble functional components which can directly or indirectly promote lipolysis, inhibit adipocyte differentiation, inhibit the uptake of free fatty acid in adipocyte and the synthesis of triglyceride and promote skin microcirculation, thereby reducing the number and volume of adipocyte and inhibiting and eliminating fat accumulation in an interlayer of hydrophilic or hydrophobic groups of the nano liposome, and has the characteristics of good stability, high safety (no hormone), targeting slow release, synergy, good transdermal absorption, long retention time, high bioavailability and the like, thereby having ideal slimming effect.
The technical scheme is as follows: a slimming nanoliposome comprises the following components by weight percent: 0.10-30.00 parts of slimming functional components, 1.00-10.00 parts of phospholipid, 0.10-5.00 parts of sterol, 1.00-10.00 parts of emulsifier, 2.00-30.00 parts of polyalcohol and the balance of water to 100 parts.
Preferably, the slimming functional ingredient includes an effective ingredient for directly or indirectly promoting lipolysis, inhibiting differentiation of adipocytes, inhibiting uptake of free fatty acids and synthesis of triglycerides in adipocytes, promoting skin microcirculation, thereby reducing the number and volume of adipocytes, and inhibiting and eliminating fat accumulation, which may be encapsulated in the interlayer of hydrophilic or hydrophobic groups of nanoliposomes, and is at least one selected from caffeine, TEA hydriodate, carnitine, saccharide isomerate, lauroyl proline, quinoa seed extract, Bacillus/soybean fermentation product extract, Cynara scolymus leaf extract, xanthine, Papaver rhoeas extract, Silybum marianum extract, Nelumbo nucifera leaf extract, Citrus amara extract, and Chrysanthemum morifolium extract.
Preferably, the complex phospholipid comprises synthetic and natural sources, and is selected from at least one of lecithin, dipalmitoylphosphatidylcholine, soybean lecithin, distearoylphosphatidylcholine, hydroxylated lecithin, glycerophosphorylcholine, and dipalmitoylphosphatidylethanolamine.
Preferably, the sterol comprises animal and plant origin and is selected from at least one of cholesterol, dihydrocholesterol.
Preferably, the emulsifier is a nonionic surfactant selected from at least one of polysorbate-80, caprylic/capric glyceride polyglyceryl-10 esters, polysorbate-60, PEG-40 hydrogenated castor oil, polyglyceryl-2 diisostearate, PEG-20 glyceryl triisostearate, sorbitan polyether-30 tetraoleate, arachidol glucoside, cetyl PEG/PPG-10/1 dimethicone, polyglyceryl-4 isostearate, polyglyceryl-10 laurate, steareth-2, glyceryl stearate citrate, cetearyl glucoside, and PEG-60 hydrogenated castor oil.
Preferably, the polyhydric alcohol is at least one selected from the group consisting of ethanol, butylene glycol, propylene glycol, decanediol, octaethylene glycol, 1, 2-pentanediol, and 1, 2-hexanediol.
The invention also discloses a preparation method of the slimming nano liposome, which comprises the following steps:
1) mixing polyalcohol and water, heating and stirring uniformly to obtain a water phase mixture;
2) mixing phospholipid, sterol and emulsifier, stirring and heating until solid materials are completely melted to obtain an oil phase mixture;
3) adding the oil phase mixture obtained in the step 2) into the water phase mixture obtained in the step 1), adding a slimming functional component, and homogenizing at a high speed to obtain a micron emulsified body;
4) and (3) carrying out multiple high-pressure (300-1200bar) homogenization or high-speed microjet treatment on the micron emulsified body obtained in the step 3) to obtain a nanometer emulsified body with the particle size of 10-500nm, thus obtaining the nanometer emulsified body.
The third purpose of the invention is to disclose the application of the slimming nano liposome in cosmetics.
The invention has the beneficial effects that:
the slimming nano liposome can simultaneously encapsulate functional components which can directly or indirectly promote lipolysis, inhibit adipocyte differentiation, inhibit free fatty acid intake and triglyceride synthesis in adipocyte and promote skin microcirculation, thereby reducing the number and volume of adipocyte and inhibiting and eliminating fat accumulation in an interlayer of hydrophilic or hydrophobic groups of the nano liposome, and has the characteristics of good stability, high safety (no hormone), targeted slow release, synergistic effect, good transdermal absorption, long residence time, high bioavailability and the like, thereby having ideal slimming effect.
Drawings
FIG. 1 is a schematic view showing changes in the average circumference of the upper thigh.
Detailed Description
The present invention will be described below with reference to specific examples, but the present invention is not limited thereto. The materials described in the following examples are commercially available without specific reference, and the following examples are not intended to limit the scope of the present invention, and all equivalent implementations or modifications without departing from the scope of the present invention are intended to be encompassed by the present claims.
The preparation method comprises the following steps:
1) mixing polyalcohol and water, heating and stirring uniformly to obtain a water phase mixture;
2) mixing phospholipid, sterol and emulsifier, stirring and heating until solid materials are completely melted to obtain an oil phase mixture;
3) adding the oil phase mixture obtained in the step 2) into the water phase mixture obtained in the step 1), adding a slimming functional component, and homogenizing at a high speed to obtain a micron emulsified body;
4) and (3) carrying out multiple high-pressure (300-1200bar) homogenization or high-speed microjet treatment on the micron emulsified body obtained in the step 3) to obtain a nanometer emulsified body with the particle size of 10-500 nm.
Example 1
The slimming nanoliposome of the embodiment comprises the following components in parts by weight:
slimming functional components: 0.50 part of hydroiodic acid TEA salt, 1.00 part of corn poppy flower extract, 1.00 part of xanthine, 2.00 parts of carbohydrate isomer and 4.00 parts of artichoke leaf extract; phospholipid: 2.00 parts of glycerophosphorylcholine and 3.00 parts of dipalmitoyl phosphatidylcholine; sterol: 2.00 parts of cholesterol and 2.00 parts of dihydrocholesterol; emulsifier: 2.00 parts of PEG-20 methyl glucose sesquistearate and 3.00 parts of PEG-40 hydrogenated castor oil; polyol: 10.00 parts of butanediol and 3.00 parts of decanediol; 64.50 parts of water.
Example 2
The slimming nanoliposome of the embodiment comprises the following components in parts by weight:
slimming functional components: 5.00 parts of bitter orange flower extract, 20.00 parts of bacillus/soybean fermentation product extract and 5.00 parts of lotus leaf extract; phospholipid: 6.00 parts of distearoyl phosphatidylcholine and 4.00 parts of soybean lecithin; sterol: 0.10 part of dihydrocholesterol; emulsifier: 1.00 part of polyglycerol-10 laurate; polyol: 2.00 parts of 1, 2-pentanediol; 66.90 parts of water.
Example 3
The slimming nanoliposome of the embodiment comprises the following components in parts by weight:
slimming functional components: 0.05 part of caffeine and 0.05 part of carnitine; phospholipid: 1.00 part of dipalmitoyl phosphatidyl ethanolamine; sterol: 5.00 parts of cholesterol; emulsifier: 7.00 parts of caprylic/capric glyceride polyglycerol-10 esters and 3.00 parts of glycerol stearate citrate; polyol: 25.00 parts of propylene glycol and 5.00 parts of 1, 2-hexanediol; 53.90 parts of water.
Comparative example 1
The nano-liposome of the comparative example consists of the following components in parts by weight:
phospholipid: 2.00 parts of glycerophosphorylcholine and 3.00 parts of dipalmitoyl phosphatidylcholine; sterol: 2.00 parts of cholesterol and 2.00 parts of dihydrocholesterol; emulsifier: 2.00 parts of PEG-20 methyl glucose sesquistearate and 3.00 parts of PEG-40 hydrogenated castor oil; polyol: 10.00 parts of butanediol and 3.00 parts of decanediol; 73.00 parts of water.
In contrast to example 1, comparative example 1 does not contain any slimming effect ingredient.
Comparative example 2
The fiber micron emulsion of the comparative example consists of the following components in parts by weight:
slimming functional components: 0.50 part of hydroiodic acid TEA salt, 1.00 part of corn poppy flower extract, 1.00 part of xanthine, 2.00 parts of carbohydrate isomer and 4.00 parts of artichoke leaf extract; phospholipid: 2.00 parts of glycerophosphorylcholine and 3.00 parts of dipalmitoyl phosphatidylcholine; sterol: 2.00 parts of cholesterol and 2.00 parts of dihydrocholesterol; emulsifier: 2.00 parts of PEG-20 methyl glucose sesquistearate and 3.00 parts of PEG-40 hydrogenated castor oil; polyol: 10.00 parts of butanediol and 3.00 parts of decanediol; 64.50 portions of water
Compared with the example 1, the micron emulsified body obtained by the comparative example 2 after high-speed homogenization is not subjected to multiple times of high-pressure homogenization or high-speed microjet treatment.
The bodies prepared in examples 1 to 3 and comparative examples 1 to 2 were subjected to performance evaluations, which included: 1. stability test
The samples prepared in examples 1 to 3 and comparative examples 1 to 2 were centrifuged at 3000RPM/30min and placed in a 45 ℃ incubator for 3 months, and the properties, particle size and PDI (polydispersity index) of the samples were examined at 0 day, 30 days, 60 days and 90 days, respectively, and the results of the measurements are shown in Table 1.
As can be seen from Table 1, the nanoliposome (examples 1-3, comparative example 1) prepared according to the present invention can pass the centrifugal test, has no obvious change, has good stability, has particle size distribution between 10-100nm even after standing for 90 days, has PDI less than 0.4, has no agglomeration, delamination and other abnormal phenomena, and meets the actual use requirements.
2. Safety test
The liposome preparations of examples 1 to 3 were subjected to a human skin occlusion test for 48 hours, respectively. 22 healthy volunteers aged 24-36 years are selected, the equal weight (0.05g) of the nano-liposome prepared in the examples 1-3 is respectively smeared on a patch device, the patch device is taken down after being pasted on the same position on the back of the volunteer for 24 hours, whether the skin has the phenomena of redness or red spots and the like is checked, the skin is scored according to the scoring standard, the result is checked once after 48 hours, and the specific result is shown in table 2.
As can be seen from Table 2, the liposome prepared according to the present invention can pass the 48-hour human skin occlusion test, which shows that the liposome prepared according to the present invention does not cause skin irritation.
3. Inhibition of adipocyte differentiation assay
The effect of inhibiting adipocyte differentiation was tested by quantifying the inhibition of the differentiation of 3T3-L1 preadipocytes into adipocytes with PERILIPIN fluorescence. Preadipocytes were cultured at 37 ℃ for 4 hours using the liposomes of the fibrillar nanoliposomes prepared in examples 1-2 and comparative example 1, respectively, after 20-fold dilution, and their metabolic activity was evaluated by assaying the activity of G6PDH (adipocyte metabolite, enzyme essential for differentiation), and the specific results are shown in Table 3.
As can be seen from Table 3, the fibrillar nanoliposome prepared according to the present invention can effectively inhibit the differentiation of adipocytes after being diluted 10 times.
4. Test for slimming efficacy
The samples prepared in example 1 and comparative examples 1-2 were added to the same cream base at a ratio of 20.00% and then distributed to 20 healthy women aged 23-48 for double-blind testing, requiring 2.00mg/cm twice a day in the morning and evening2The amount of the composition is applied to the upper thigh, the continuous application is carried out for 8 weeks, the change of the thigh circumference of the same part is tested at 0 day, 28 days and 56 days of application respectively, and the average change value is counted, and the specific result is shown in figure 1.
As can be seen from FIG. 1, the decrease in the average circumference of the upper thigh of a female using the cream containing the slimming nanoliposomes prepared in example 1 is more significant than the decrease in the circumference of the thigh of a female using comparative example 1 without any slimming functional ingredients and comparative example 2 without nano-treatment, which indicates that the slimming nanoliposomes prepared by the present invention can effectively decrease the circumference of the thigh with long-term use and have a better slimming effect.
It is to be understood that the above-described embodiments of the present invention are merely illustrative of or explaining the principles of the invention and are not to be construed as limiting the invention. Therefore, any modification, equivalent replacement, improvement and the like made without departing from the spirit and scope of the present invention should be included in the protection scope of the present invention. Further, it is intended that the appended claims cover all such variations and modifications as fall within the scope and boundaries of the appended claims or the equivalents of such scope and boundaries.
Claims (8)
1. A slimming nanoliposome is characterized by comprising the following components in parts by weight: 0.10-30.00 parts of slimming functional components, 1.00-10.00 parts of phospholipid, 0.10-5.00 parts of sterol, 1.00-10.00 parts of emulsifier, 2.00-30.00 parts of polyalcohol and the balance of water to 100 parts.
2. The fibrillar nanoliposome of claim 1, wherein the fibrillar functional ingredient is selected from at least one of caffeine, TEA salt of hydriodic acid, carnitine, saccharide isomerate, lauroyl proline, quinoa seed extract, Bacillus/soybean fermentation product extract, Cynara scolymus leaf extract, xanthine, corn poppy flower extract, Silybum marianum extract, lotus extract, coffee seed extract, lotus leaf extract, bitter orange flower extract, and Chrysanthemum morifolium extract.
3. The fibrillar nanoliposome of claim 1, wherein the phospholipids comprise synthetic and natural sources and are selected from at least one of lecithin, dipalmitoylphosphatidylcholine, soy lecithin, distearoylphosphatidylcholine, hydroxylated lecithin, glycerophosphocholine, dipalmitoylphosphatidylethanolamine.
4. The fibrillar nanoliposome of claim 1, wherein the sterol comprises animal and plant origin selected from at least one of cholesterol, dihydrocholesterol.
5. The fibrillar nanoliposome of claim 1, wherein the emulsifier is a non-ionic surfactant selected from at least one of polysorbate-80, caprylic/capric glyceride polyglycerol-10 esters, polysorbate-60, PEG-40 hydrogenated castor oil, polyglycerol-2 diisostearate, PEG-20 triisoglycerol stearate, sorbitan polyether-30 tetraoleate, arachidol glucoside, cetyl PEG/PPG-10/1 polydimethylsiloxane, polyglycerol-4 isostearate, polyglycerol-10 laurate, steareth-2, glyceryl stearate citrate, cetearyl glucoside, PEG-60 hydrogenated castor oil.
6. The fibrillar nanoliposome of claim 1, wherein the polyol is at least one selected from the group consisting of ethanol, butylene glycol, propylene glycol, decanediol, octaethylene glycol, 1, 2-pentanediol, and 1, 2-hexanediol.
7. A method of preparing the fibrillar nanoliposome of claims 1 to 6, comprising the steps of:
1) mixing polyalcohol and water, heating and stirring uniformly to obtain a water phase mixture;
2) mixing phospholipid, sterol and emulsifier, stirring and heating until solid materials are completely melted to obtain an oil phase mixture;
3) adding the oil phase mixture obtained in the step 2) into the water phase mixture obtained in the step 1), adding a slimming functional component, and homogenizing at a high speed to obtain a micron emulsified body;
4) and (3) carrying out multiple high-pressure 300-1200bar homogenization or high-speed microjet treatment on the micron emulsified body obtained in the step 3) to obtain a nanometer emulsified body with the particle size of 10-500nm, thus obtaining the nano emulsified body.
8. Use of the fibrillar nanoliposome according to any one of claims 1 to 6 in cosmetics.
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Cited By (6)
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| CN111658557A (en) * | 2020-06-22 | 2020-09-15 | 泉后(广州)生物科技研究院有限公司 | Nano-structure liposome capable of eliminating eye bags immediately and preparation method and application thereof |
| CN113249964A (en) * | 2021-05-06 | 2021-08-13 | 江苏金太阳纺织科技股份有限公司 | Fat burning and slimming finishing agent for fabric and preparation method thereof |
| CN113476360A (en) * | 2021-06-22 | 2021-10-08 | 宝萃生物科技有限公司 | Composition for improving pouch and preparation method and application thereof |
| CN113599294A (en) * | 2021-07-22 | 2021-11-05 | 广东省科学院化工研究所 | Nano composition and preparation method and application thereof |
| CN114983887A (en) * | 2022-05-30 | 2022-09-02 | 广州麦嘉昕生物科技有限公司 | Beautiful and light herbal liquid |
| CN115006272A (en) * | 2022-06-28 | 2022-09-06 | 广州嘉瑞新材料科技有限公司 | Submicron liposome |
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| CN111658557A (en) * | 2020-06-22 | 2020-09-15 | 泉后(广州)生物科技研究院有限公司 | Nano-structure liposome capable of eliminating eye bags immediately and preparation method and application thereof |
| CN113249964A (en) * | 2021-05-06 | 2021-08-13 | 江苏金太阳纺织科技股份有限公司 | Fat burning and slimming finishing agent for fabric and preparation method thereof |
| CN113476360A (en) * | 2021-06-22 | 2021-10-08 | 宝萃生物科技有限公司 | Composition for improving pouch and preparation method and application thereof |
| CN113599294A (en) * | 2021-07-22 | 2021-11-05 | 广东省科学院化工研究所 | Nano composition and preparation method and application thereof |
| CN114983887A (en) * | 2022-05-30 | 2022-09-02 | 广州麦嘉昕生物科技有限公司 | Beautiful and light herbal liquid |
| CN115006272A (en) * | 2022-06-28 | 2022-09-06 | 广州嘉瑞新材料科技有限公司 | Submicron liposome |
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Application publication date: 20200417 |