CN108653693A

CN108653693A - A kind of slim fat rush digestion micro emulsion and preparation method thereof that disappears

Info

Publication number: CN108653693A
Application number: CN201810621217.2A
Authority: CN
Inventors: 魏坤; 万淑倩
Original assignee: South China University of Technology SCUT
Current assignee: South China University of Technology SCUT
Priority date: 2018-06-15
Filing date: 2018-06-15
Publication date: 2018-10-16

Abstract

The invention discloses a kind of slim fat that disappears to promote digestion micro emulsion and preparation method thereof.The micro emulsion includes following components：The slim fat that disappears promotees digestion activated complex, grease, emollient, moisturizer, surfactant, cosurfactant, conditioning agent, deionized water.This method is：The blended emulsifier of oil phase and surfactant, cosurfactant formation that the aid digestion activated complex of the slim fat that disappears, grease are formed is stirred together, then deionized water is added dropwise, formation type colostrum, deionized water formation type lotion is added, it is eventually adding the pH value that conditioning agent adjusts lotion, continue to stir a few hours, being made, there is the slim fat that disappears to promote digestion micro emulsion.The present invention has significant fat reducing effect, the triglycerides in adipocyte can be quickly set to reduce, the transdermal characteristic of critical active drug is fine, it can be efficiently absorbed and utilize, and find that it has the function of centainly promoting white fat milkproduct, this can accelerate human body self-energy to be metabolized, and play the function of self fat reducing.

Description

A kind of slim fat rush digestion micro emulsion and preparation method thereof that disappears

Technical field

The invention belongs to technical field of traditional Chinese medicines, more particularly to a kind of slim fat that disappears to promote digestion micro emulsion and preparation method thereof.

Background technology

Common belief is that：Obesity is because Energy intaking is more than energy expenditure and causes fat in human body Accumulation, i.e., so-called overnutrition are fat the reason of occurring.Medically, the acute fat different mechanisms formed of root and reason, it is main It is classified as simple obesity and Secondary Obesity.Simple obesity can be divided into constitutional obesity and alimentary obesity：Constitution Property obesity mainly caused by lipocyte proliferation, have heredity：And alimentary obesity is referred to alternatively as acquired obesity (exogenous) fat, its formation mainly crosses Retained due to body nutrition, takes in excessive power, promotes adipocyte hypertrophy and increasing Caused by life.Secondary Obesity is that a kind of dysendocrinism is fat, is typically that morbidity is former with certain disease, by influencing body Internal system, central nervous system is led and the obesity that is formed, including nanosom obesity.And in obese people, it is most of Belong to simple obesity.

Bariatric method include mainly change lifestyles, drug therapy and operative treatment.Change lifestyles use Dietetic treatment and aerobic exercise can not only maintain the long-term efficacy of loss of weight, but also can improve patient's cardio-pulmonary function, reduce fertilizer It is fat caused by various complication but this be a long-term process, need to adhere to.The drug therapy cardinal principle of doctor trained in Western medicine is to use It is several below：Appetite inhibitor digests and assimilates retarding agent, metabolic improver.U.S. FDA is allowed for the medicine of weight-reducing purposes at present Object has sibutramine and orlistat.Weight reduction with drugs has certain effect, can reach without a kind of drug and lose weight rapidly And weight loss effect is maintained for a long time, and prolonged administration of drugs will produce some side effects such as metabolic disorder.Operative treatment includes Water polo therapy in Bariatric operations, degreasing orthopedic and stomach.Operative treatment can reach fat-reducing effect and dimension in a short time It holds that the time is longer, but performs the operation and implement have certain fitness and age requirement to patient, and with certain operation risk And postoperative complications.With the getting worse of problem of obesity, a kind of markedly fast of an urgent demand, curative effect are apparent, are able to maintain that loss of weight, The weight-reducing mode of few side effects.

Traditional Chinese medicine has long history and good exact effect for prevention obesity and its caused illness.In Think in medicine fat reason mainly with zang-fu disharmony, situations such as vim and vigour are unsmooth, speen-kidney dificiency, stomach fire cross Sheng it is related, therefore its Principle of reatment predominantly and stomach invigorating the spleen, dispelling dampness and promoting diuresis, the promoting flow of qi and blood circulation, soothing liver-gallbladder, temperature male wind-supplying kidney etc., with reach conditioning viscera with Endocrine promotes the purpose of body metabolism and toxin expelling.Chinese medicine is had no toxic side effect with a kind of mild, integrally-regulated mode, allows body Body is in the balance stable state of a self-control.

The convenient administration approach of Chinese medicine is absorbed after drug oral through gastrointestinal tract, based on oral through stomach and intestine after drug oral Tract epithelial cell is distributed to each histoorgan into the laggard human body of blood circulation system transhipment and plays a role, but extract oral is given What medicine generally required month or more takes the period, and dose is big, takes orally after a series of processes such as gastric digestion, active ingredient It is high to reach small intestine difficulty, causes absorptivity low, it is difficult to see that apparent weight loss effect, long-term use are also easy to kidney, liver Larger load is caused, or even causes to damage.

Determining dosage form is made in compounding after traditional Chinese medicine extyaction by the present invention, using transdermal drag delivery, by oozing The bleeding agent of the composites such as saturating agent improves osmosis, and moisturizer improves skin hydration degree, to promote Chinese medicine effective Ingredient rapidly and efficiently penetrates epidermis, while ancient Chinese medical classics cave is theoretical in application, and product is applied on the point of acupuncture point, makes active ingredient can With the position that goes directly, the absorptivity of Chinese medicine is substantially increased, and dosage is low more than oral medication amount, white fat can be effectively facilitated Fat cell advantageously reduces fat to cream-coloured adipocyte transforming, changes Chinese medicine tradition and needs the oral feelings that can just tell on Condition realizes external application Chinese medicine and reaches excellent lowering blood-fat and reducing weight slimming effect.

Invention content

Insufficient according to prior art, an object of the present invention is to provide a kind of slim fat rush digestion micro emulsion that disappears.Purpose Two be to provide it is this it is slim disappear fat promote digestion micro emulsion preparation method.It is micro- that the third purpose is to provide this slim fat rush digestion that disappears Application of the breast in the slim fat that disappears promotees digestion.

Used technical solution is as follows in order to achieve the above objectives by the present invention：

A kind of slim fat rush digestion micro emulsion that disappears, micro- composition of milk are divided by its composition：

The slim fat that disappears of described one kind promoting digestion micro emulsion and belongs to w/o/w structures.

Further, Altai Bupleurum Root (BUPLEURUM FALCATUM) root extract, asafoetide (FERULA ASSA FOETIDA) root extract, Egyptian Nymphaea caerulea (NYMPHAEA COERULEA) flower extract pacify eastern aloe (ALOE ANDONGENSIS) leaf extract, Queensland nut (MACADAMIA TERNIFOLIA) extract, Chinese anise (ILLICIUM VERUM) berry extract, Brazil nut (BERTHOLLETIA EXCELSA) pericarp extract, Brazil perfume cocoa (PAULLINIA CUPANA) berry extract, white clover (TRIFOLIUM REPENS) extract, white lilac (SYRINGAOBLATA AFFINIS) extract, Amomum cardamomum (AMOMUM KRAVANH) extract, oldenlandia diffusa (OLDENLANDIA DIFFUSA) root Extract, white birch (BETULA ALBA) leaf extract, goldenseal (HYDRASTIS CANADENSIS) extract, wedge base kelp (LAMINARIA OCHROLEUCA) extract, snowdrop (GALANTHUS NIVALIS) seed extract, bacillus/soybean Tunning extract, ginger (ZINGIBER OFFICINALE) root extract, tragacanth (ASTRAGALUS GUMMIFER) root More than one in extract.

Further, it is by following composition of proportions that the slim fat that disappears, which promotees digestion activated complex, they are all by one The processes such as series of wash, immersion, grinding, supercritical extract, rotary evaporation, freeze-drying obtain.

Component	Proportion
		Altai Bupleurum Root root extract	1~2.5%
Asafoetide root extract	0.01~0.05%
		Egyptian blue water lily flower extract	0.1~0.2%
The eastern Folium Aloe extract of peace	1~15%
		Queensland nut extract	1.5~2.8%
Chinese anise berry extract	0.3~1%
		Brazil nut pericarp extract	2~6%
Brazilian perfume cocoa berry extract	10~28%
		White clover extract	0.5~1%
Faeces Passeris extract	1.2~7%
		Amomum cardamomum extract	0.2~1.5%
Oldenlandia diffusa root extract	0.02~0.1%
		White birch leaf extract	0.005~0.7%
Goldenseal extract	1.6~8.5%
		Wedge base Thallus Laminariae (Thallus Eckloniae) extract	2.1~10%
Snowdrop seed extract,	3~9%
		Bacillus/fermented soybean product extract	0.6~3%
Ginger-root extract	1~8%
		Tragacanth root extract	0.5~10%

Further, the grease is jojoba oil, caryophyllus oil, apricot kernel oil, coconut oil, the cruel amine salt of laruyl alcohol phosphoric acid, tea Seed oil, avocado oil, angle soft-shelled turtle alkane, cetostearyl alcohol, cetearyl glucoside, oleic acid, ginger (ZINGIBER OFFICINALE) root One in oil, cupressus sempervirens (CUPRESSUS SEMPERVIRENS) oil, Juniperus communis (JUNIPERUS COMMUNIS) fruit oil Kind or more.

Further, the emollient be nutmeg acid isopropyl ester, olive oil, diethylhexyl hexamethylene, sher butter, Palm fibre puts sour ethylhexyl, palm fibre puts isopropyl propionate, ermine oil, wheat-germ oil, sunflower seeds oleic acid, isononyl isononanoate, silicone oil, tristearin Sour cetyl, cetanol isononoate, carbonic acid dibutyl ester, cetanol palm fibre put acid esters, Permethyl 99A, isohexadecane, poly- methyl-prop Olefin(e) acid glyceride, poly- light base stearate, pentaerythritol tetraoctyl stearate, nutmeg acid tetradecane ester or palm fibre are put in misery ester More than one.

Further, the moisturizer be Sodium Hyaluronate, neural phthalein amine more than one；The surfactant is sweet Oleostearin acid esters, PEG-100 stearates, polyoxyethylene (40) rilanit special, lecithin, alkyl glucosides sugared former times, Tween-80 Or one or more of Arlacel-80.

Further, the cosurfactant is glycerine, glycerin polyether -26, butanediol, propylene glycol, ethyl alcohol, ethylene glycol One or more of single ethylether or polyglycerol fatty acid are cruel.

Further, the conditioning agent is in citric acid, tartaric acid, phosphoric acid, salicylic acid, sodium hydroxide or triethanolamine More than one.

A kind of slim fat that disappears promotees the preparation method of digestion micro emulsion, includes the following steps：

(1) surfactant is weighed by formula rate, cosurfactant is stirred, forms mixing and emulsifying after ultrasound Agent；

(2) it weighs the slim fat that disappears by recipe ratio and promotees digestion activated complex, grease and emollient, heat shape after mixing At oil phase；

(3) moisturizing active constituent and deionized water are weighed by recipe ratio, is uniformly mixed and forms inner aqueous phase；(4) by step (2) In oil phase and step (1) in blended emulsifier be stirred, inner aqueous phase is then added dropwise, formation type colostrum is stirring Continue that deionized water formation type lotion is added dropwise under state, it is 6~7 to be eventually adding conditioning agent and adjust the pH value of lotion, is continued Stirring 6~for 24 hours, being made, there is the slim fat that disappears to promote digestion micro emulsion.

10, the preparation method according to right 9, which is characterized in that the mixing speed is 500~1200rpm, institute The heating temperature stated is 30~80 DEG C.

Compared with prior art, advantage of the invention is that：

1. the slim fat that disappears used in promotees the extract that digestion activated complex is natural plants, not will produce not to human body Good side effect.

2. the present invention uses the principle of Chinese medicine, with a kind of mild, have no toxic side effect, integrally-regulated mode allows at body In the balance stable state of a self-control, without causing body founction metabolism disorderly.

3. take that the period is long, and dose is big the present invention overcomes conventional oral administration, the problems such as stomach and intestine portion first pass effect, Ancient Chinese medical classics cave is theoretical in, and product is applied on the point of acupuncture point, so that active ingredient is gone directly position, substantially increases Chinese medicine Absorptivity, and dosage is low more than oral medication amount.

4. the present invention studies after tested, there is significant fat reducing effect, can quickly make the glycerine three in adipocyte Ester is reduced, and transdermal the study found that the transdermal characteristic of critical active drug is fine, can be efficiently absorbed and be utilized, Er Qiefa Now it has the function of centainly promoting white fat milkproduct, this can accelerate human body self-energy to be metabolized, and play the function of self fat reducing.

Description of the drawings

Fig. 1 is to pacify the fragrant cocoa berry extract of eastern Folium Aloe extract and Brazil transdermal cumulative release curve interior for 24 hours.

Fig. 2 is that the oil red O stain figure before micro emulsion is added in external evoked adipocyte；

Fig. 3 is that the oil red O stain figure after micro emulsion is added in external evoked adipocyte.

Specific implementation mode

The present invention will be further specifically described in detail with reference to specific embodiments, but embodiments of the present invention are not It is limited to this, for not specifically specified technological parameter, can refer to routine techniques progress.

Embodiment 1

The present embodiment provides a kind of slim fat that disappears to promote digestion micro emulsion, is made of the component of following parts by weight：

(1) active constituent in each active medicine is extracted：By Altai Bupleurum Root root, asafoetide root, Egyptian blue nymphaea tetragona, An Dong Chinese aloe leaf, Queensland nut, Chinese anise fruit, Brazil nut pericarp, Brazil perfume cocoa, white clover, white lilac, Amomum cardamomum, in vain Flower tang grass roots, white birch leaf, goldenseal, wedge base kelp, snowflake lotus seed, race, tragacanth root is first put into mortar respectively to be smashed to pieces, Then use the extraction of the mixed solution (volume ratio alcohol/water=1~3) of alcohol and water multiple, then with Rotary Evaporators in corresponding temperature Corresponding extract liquor is evaporated to remove the volatile components such as alcohol under degree and rotating speed, is finally freeze-dried extract It stores with spare.Bacillus/fermented soybean product is then directly to be fermented to soybean with bacillus, then takes out Its zymotic fluid is taken, the fermentation broth extract for being centrifuged and being obtained by filtration.

(2) configured each component in proportion, weigh surfactant by formula rate, cosurfactant is stirred, Blended emulsifier is formed after ultrasound.

(3) it weighs the slim fat that disappears by recipe ratio and promotees digestion activated complex, grease and emollient, heat shape after mixing At oil phase, heating temperature is 60 DEG C.

(4) moisturizing active constituent and deionized water are weighed by recipe ratio, is uniformly mixed and forms inner aqueous phase.

(5) blended emulsifier in the oil phase and step 1 in step 2 is stirred, inner aqueous phase, shape is then added dropwise It is molded colostrum, continues to be slowly added to deionized water formation type lotion dropwise under stirring, conditioning agent is eventually adding and adjusts breast The pH value of liquid is 6.5, continues to stir 12h, mixing speed 800rpm, and being made, there is the slim fat that disappears to promote digestion micro emulsion.

Fig. 1 is to pacify the fragrant cocoa berry extract of eastern Folium Aloe extract and Brazil transdermal cumulative release curve interior for 24 hours.Such as Figure, we simulate the skin of people with pigskin, have done percutaneous penetration, have studied the fragrant cocoa of the eastern Folium Aloe extract of peace and Brazil Berry extract is in Transdermal absorption situation interior for 24 hours, and as a result as figure shows, the transdermal preparation for pacifying eastern Folium Aloe extract is 80%, Brazil's perfume cocoa berry extract is 70.5%, and the concentration has reached drug useful effect concentration.

Fig. 2 is that the oil red O stain figure before micro emulsion is added in external evoked adipocyte, and Fig. 3 is that external evoked fat is thin The oil red O stain figure after micro emulsion is added in born of the same parents.Mature fat cell model is established in vitro, and the slim fat that disappears then is added and promotees digestion Micro emulsion acts on for 24 hours, then intracellular fatty situation is characterized with the shade of oil red O stain and the area of dyeing, such as schemes It is found that plus after micro emulsion, the area of dyeing is fewer than control group, and the degree for catching color is also lower than control group, may indicate that thin (triglycerides can dye red by oil red O specificity, catch the deeper face of degree of color for the content of triglyceride significant decrease of intracellular Triglycerides contained by the bigger representative of product is more).

Embodiment 2

Embodiment 3

It should be appreciated that the detailed description carried out above to technical scheme of the present invention by optimal enforcement example is schematical And not restrictive, and it cannot be said that the present invention specific implementation mode be only limitted to this, for the general of the technical field of the invention For logical technical staff, without departing from the inventive concept of the premise, modify to the technical solution recorded in each embodiment, Or equivalent replacement of some of the technical features, it all shall be regarded as belonging to what claims that the present invention submits determined Scope of patent protection.

Claims

1. a kind of slim fat that disappears promotees digestion micro emulsion, which is characterized in that micro- composition of milk is divided by its composition：

Component Proportion The slim fat that disappears promotees digestion activated complex 10~70% Grease 3~20% Emollient 0.5~5% Moisturizer 1~6% Surfactant 4~30% Cosurfactant 1~4% Conditioning agent 0.01~5% Deionized water 20~80%

2. the slim fat that disappears promotees digestion micro emulsion according to claim 1, which is characterized in that the slim aid digestion activity of the fat that disappears is multiple Conjunction object is Altai Bupleurum Root root extract, asafoetide root extract, Egyptian blue water lily flower extract, the eastern Folium Aloe extract of peace, Australia Continent nut extract, Chinese anise berry extract, Brazil nut pericarp extract, Brazil's perfume cocoa berry extract, white clover carry Take object, Faeces Passeris extract, Amomum cardamomum extract, oldenlandia diffusa root extract, white birch leaf extract, goldenseal extract, Wedge base Thallus Laminariae (Thallus Eckloniae) extract, snowdrop seed extract, bacillus/fermented soybean product extract, ginger-root extract, tragacanth root One or more of combination in extract.

3. the slim fat that disappears promotees digestion micro emulsion according to claim 2, which is characterized in that it is multiple that the slim fat that disappears promotees digestion activity It is by following composition of proportions to close object, they are all by a series of washings, immersion, grinding, supercritical extract, rotary evaporation, cold The processes such as dry are lyophilized to obtain.

4. the slim fat that disappears of one kind according to claim 1 promotees digestion micro emulsion, which is characterized in that the grease is Jojoba Oil, caryophyllus oil, apricot kernel oil, coconut oil, the cruel amine salt of laruyl alcohol phosphoric acid, tea-seed oil, avocado oil, angle soft-shelled turtle alkane, cetostearyl alcohol, spermaceti One or more of stearyl glucoside, oleic acid, ginger oil, Cupressus semperviren wood oil, Juniperus communis fruit oil.

5. the slim fat that disappears of one kind according to claim 1 promotees digestion micro emulsion, which is characterized in that the emollient is nutmeg Isopropyl propionate, olive oil, diethylhexyl hexamethylene, sher butter, palm fibre put sour ethylhexyl, palm fibre puts isopropyl propionate, ermine oil, small Wheat germ oil, sunflower seeds oleic acid, isononyl isononanoate, silicone oil, cetyl stearate, cetanol isononoate, carbonic acid dibutyl ester, Cetanol palm fibre puts acid esters, Permethyl 99A, isohexadecane, polymethyl acid glyceride, gathers light base stearate, pentaerythrite four Isostearate, nutmeg acid tetradecane ester or palm fibre put one or more of misery ester.

6. the slim fat that disappears of one kind according to claim 1 promotees digestion micro emulsion, which is characterized in that the moisturizer is hyalomitome Sour sodium, neural phthalein amine more than one；

The surfactant is stearine, PEG-100 stearates, polyoxyethylene (40) rilanit special, lecithin One or more of fat, alkyl glucosides sugared former times, Tween-80 or Arlacel-80.

7. the slim fat that disappears of one kind according to claim promotees digestion micro emulsion, which is characterized in that the cosurfactant is Glycerine, glycerin polyether -26, butanediol, propylene glycol, ethyl alcohol, ethylene glycol monomethyl ether or polyglycerol fatty acid it is cruel in it is a kind of with On.

8. according to claim one kind it is slim disappear fat promote digestion micro emulsion, which is characterized in that the conditioning agent be citric acid, One or more of tartaric acid, phosphoric acid, salicylic acid, sodium hydroxide or triethanolamine.

9. any one of the claim 1~8 slim fat that disappears promotees the preparation method of digestion micro emulsion, which is characterized in that including following Step：

(1) surfactant is weighed by formula rate, cosurfactant is stirred, forms blended emulsifier after ultrasound；

(2) it weighs the slim fat that disappears by recipe ratio and promotees digestion activated complex, grease and emollient, be thermally formed oil after mixing Phase；

(3) moisturizing active constituent and deionized water are weighed by recipe ratio, is uniformly mixed and forms inner aqueous phase；

(4) blended emulsifier in the oil phase and step (1) in step (2) is stirred, inner aqueous phase, shape is then added dropwise It is molded colostrum, continues that deionized water formation type lotion is added dropwise under stirring, conditioning agent is eventually adding and adjusts lotion PH value is 6~7, continues stirring 6~for 24 hours, and being made, there is the slim fat that disappears to promote digestion micro emulsion.

10. according to the preparation method described in right 9, which is characterized in that the mixing speed is 500~1200rpm, described Heating temperature is 30~80 DEG C.