KR20060129890A - Cosmetic compositions for sliming - Google Patents

Abstract

A cosmetic composition for sliming the body is provided to decompose fat in the body stably by using stabilized caffeine with nanoliposome, so that cellulite is removed and skin elasticity is enhanced. The hydrosome type of cosmetic composition for sliming the body comprises nanoliposome including caffeine, wherein the amount of nanoliposome is 0.1-20.0 wt.% based on the total weight of the composition; the amount of caffeine is 1.0-30.0 wt.% based on the total weight of nanoliposome; the hydrosome is formed by using an emulsifier including sorbitan stearate and sorbityl laurate; the amount of emulsifier is 0.01-10.0 wt.% based on the total weight of the composition; and the composition is formulated as solution, suspension, emulsion, paste, gel, cream, lotion, powder, soap, surfactant-containing cleansing, oil, powder foundation, emulsion foundation, wax foundation or spray.

Description

Slimming cosmetic composition {Cosmetic Compositions for Sliming}

The present invention relates to a slimming cosmetic composition of a hydrosome formulation comprising nanoliposomes stabilized by inclusion of caffeine.

Obesity is usually an abnormal enlargement of subcutaneous fat tissue under the skin layer. This phenomenon is usually caused by excess calories consumed by the foods consumed, whereas energy consumption is low when the calories consumed are accumulated in the form of fat in the body. The obesity phenomenon is considered as an enemy of health in modern society because the fat accumulated under the skin layer not only makes the body fat and loses its physical beauty but also causes various adult diseases such as high blood pressure and diabetes.

Obesity can be categorized into physiological, psychological, and life factors. Physiological factors include decreased metabolic activity of somatic cells, low calorie consumption, and decreased blood circulation. And psychological tensions such as nervousness, and life factors include overeating, lack of exercise, excessive intake of carbohydrates and sugars, drinking and smoking.

Skin, the largest organ of the human body, is about 1.8 m ² , about 2-4 mm thick, and about 3 kg thick. It consists of the epidermis, dermis and subcutaneous fat layer. In particular, the subcutaneous fat layer under the dermis is composed of the lobules of adipocytes, which act as a cushion to absorb and protect the organs inside the skin against external heat, and nutrients form triacylglycerol. It is also stored as an energy source if needed.

However, in terms of skin cosmetics, the subcutaneous fat layer causes obesity. In particular, due to excessive accumulation of fat components in a specific area called cellulite, a phenomenon such as sagging, loss of elasticity, and obesity may be caused in a specific area such as the face, waist, thigh, and chest.

In the human body, fat accumulates in the adipocytes, adipocyete, in the form of triacylglycerol, so it is necessary to remove triacylglycerol to break down fat. Triacylglycerol is decomposed into triglycerides and fatty acids by the action of a lipolytic enzyme called triacylgycerol lipase, which is used to generate energy sources necessary for the metabolic process of the human body. At this time, triacyl glycerol lipase, an enzyme involved in lipolysis, is activated by cAMP (cyclic adenosine monophosphate), which is a cell activity modulator that regulates the activity of various enzymes present in human skin.

Recently, various ingredients for decomposing fat components accumulated in the skin and body have been developed. One of them is caffeine (caffeine) contained in the coffee or green tea component is known to have the effect of promoting the activity of triacylglycerollipase, an enzyme that breaks down fat in the human body to promote lipolysis and metabolism. In particular, caffeine is known as a substance that promotes lipolysis in the body by increasing the amount of cAMP, which aids in lipolytic activity, and cAMP by inhibiting nucleotide phosphodistease, an enzyme that degrades cAMP. It is also known to increase the amount of. Recently, various studies related to the lipolysis process have been conducted, including a mechanism to promote the lipolysis by activating triacylglycerol lipase, which is a cAMP increased by caffeine.

In addition, in view of the physiological function of the skin, it is very difficult to believe that the active ingredients of cosmetics applied to the skin surface are easily absorbed into the skin. Obstacles to preventing transdermal absorption of active ingredients include:

Sebum: The sebum secreted by the sebaceous glands flows out of the surface of the skin to form a sebaceous membrane, which builds up a strong barrier against foreign matter penetration. The presence of such sebum is not only a barrier to external foreign matter penetration but also plays a very important function of suppressing evaporation of moisture from inside the skin. Due to this thorough waterproof function, even moisture from the outside becomes difficult to be absorbed into the skin. This disordered function of sebum is the same in the hair follicles as well as in the general skin area. The follicle entrance appears to be a fragile area where foreign matter can easily enter, and the follicles descend from the entrance of the skin surface along the follicular canal to the subcutaneous tissue, making it look like an infiltration path that can easily contact the epidermis and the dermis. Sebum, however, also forms a thorough shield in the hair follicles. Of course, the hair follicles and the wall of the follicles form a stratum corneum, but is not usually covered with a hard stratum corneum like the epidermis may be relatively easy to absorb the skin, but also in that it forms a barrier to skin absorption.

Keratinous tissue and waste products: The keratin of the epidermis is broken down into scales at the very end of the keratinization process. If these pieces of scale are still attached to the skin while being adhered by sebum on the surface of the skin, this may also be a physical obstacle to skin absorption. In addition, various organic and inorganic waste products secreted from the skin cover the skin, which is also an obstacle.

The stratum corneum: The stratum corneum layer of about 20 layers of dead cell membranes not only acts as a kind of cellophane, but also binds with sebum to form a thick sheet of cardboard. And when the thickness of the stratum corneum is thicker than normal, skin absorption barriers are further strengthened.

Cell membranes: Cell membranes are composed mainly of phospholipids, which are complex fat components. Phospholipids themselves have the property of retaining moisture. Cell membranes based on these phospholipids are fats and do not open easily unless they are lipophilic or fat-soluble.

Therefore, the most important factor in developing transdermal absorption of caffeine having excellent lipolytic effect and applying cosmetic composition is to develop and formulate a method for promoting percutaneous absorption to express desired effect expected from caffeine. Technical development is needed.

However, this technique has a fundamental methodological difference from the application of caffeine proposed as a cosmetic or food beverage. In addition, when applied as a cosmetic in a state that does not properly promote subcutaneous fat delivery of caffeine, the amount delivered to the subcutaneous fat is very small, and as a result, the lipolytic effect of caffeine can not be expected. That is, in order to effectively and substantially tolerate the lipolysis effect of caffeine reported to date, it can be said that there is a need for a method of improving bioavailability by increasing or promoting the percutaneous absorption rate of caffeine.

Thus, the present inventors have studied a method that can promote the percutaneous absorption of caffeine in order to solve the above problems, the caffeine is included in the nanoliposomes stabilized, and the nanoliposomes having a structure similar to the lamellar structure of the stratum corneum layer It has been found that application to lamellar gel network liquid crystals (hydrosomes) can dramatically improve subcutaneous fat delivery of caffeine. In addition, the present inventors found that when the caffeine having improved transdermal absorption in the above-described method is applied to the slimming cosmetic composition, the present invention shows excellent subcutaneous fat decomposition effect, cellulite removal effect and elasticity enhancing effect of fat cells. Completed.

Accordingly, it is an object of the present invention to provide a slimming cosmetic that promotes percutaneous absorption of caffeine.

Other objects and advantages of the present invention will become apparent from the following detailed description and claims.

According to an aspect of the present invention, the present invention provides a lamellar gel network liquid crystal slimming cosmetic composition comprising nanoliposomes stabilized by inclusion of caffeine.

Hereinafter, the present invention will be described in more detail.

Caffeine (caffeine) included in the slimming cosmetic composition of the present invention is one of the drugs widely used around the world, the chemical formula is C ₈ H ₁₀ O ₂ N _{4 It} is a xanthine structure having three methyl groups. Caffeine is present in Brazilian coffee beans at 1.0-1.5% and oriental rooibos leaves at 1.0-5.0%. It is a white, light crystal that is difficult to dissolve in cold water, melts well in hot water, and has a bitter taste. Caffeine has pharmacological effects such as central nervous system stimulant, cardiovascular agent, and diuretic. Especially, it is widely used in slimming cosmetics to improve body lines due to its good decomposition effect of fat (cellulite).

Cellulite refers to the prominence of fat, especially in the thighs and buttocks. Cellulite is a strand of skin fibrous tissue that connects the skin and deep tissue layers to form compartments containing fat cells. As the cells containing fat grow in size, the compartments become larger as a result. Is formed.

Caffeine (caffeine) is known to increase the amount of cAMP (cyclic adenosine monophophate) that promotes lipolysis activity to promote the lipolytic activity in the body.

Caffeine increases the amount of cAMP by inhibiting Nucleotide phophodistease, an enzyme that breaks down cAMP, and cAMP increased by caffeine activates triglycerol lipase, a lipolytic enzyme. It will promote decomposition.

Another feature of the present invention is that caffeine is used to stabilize the inclusion in nanoliposomes.

Liposomes are defined as spherical phospholipid vesicles of colloidal particles that associate themselves. Liposomes composed of amphiphilic molecules with water-soluble heads (hydrophilic groups) and insoluble tails (hydrophobic groups) spontaneously interact with them. Combined and ordered structure. Liposomes are classified into Small Unilamellar Vesicle (SUV), Large Unilamellar Vesicle (LUV), Multi Lamellar Vesicle (MLV), and the like according to their size and lamellarity. Such liposomes exhibiting various laminations are about 20 nm-hundreds of nm in size, have a double membrane structure similar to a cell membrane, and have a thickness of about 4 nm. Liposomes made from natural lipids such as lecithin are more biodegradable and biocompatible than liposomes made from synthetic lipids, so that water-soluble components are present in the aqueous core, and oil-soluble components are present in the phospholipid membrane. It is solubilized to encapsulate both hydrophilic and lipophilic materials. Liposomes can contain many active substances, such as active ingredients, fragrances, drugs, and vaccines, and the substances entrapped in liposomes are released slowly over time, which enhances the rigidity of the double membrane to release the inclusion substances. I can regulate it.

Until now, researches using liposomes have been actively conducted by various researchers, and most of them are used to promote transdermal absorption of active ingredients (Korean Patent Application Nos. 2000-0008212 and 2000-0042399) and “Skin Moisturizing Power”. Reinforcement "(Korean Patent Application No. 1948-7004646)," Improvement of atopic dermatitis and dry skin "(Korean Patent Application No. 2000-0027165). In addition, in the study of the conventional cosmetic composition using liposomes, the liposomes were destroyed before the active ingredient was absorbed into the skin, and thus the desired effects could not be achieved.

However, the composition of the present invention includes a nanoliposome significantly smaller particles than the liposomes described above as an active ingredient, and includes caffeine having excellent lipolysis effect on the nanoliposome as an active ingredient.

As used herein, the term "nanoliposomes" refers to liposomes having an average particle diameter of 1-100 nm as having the form of conventional liposomes. According to a preferred embodiment of the invention, the average particle diameter of the nanoliposomes is 30-70 nm. When the average particle diameter of the nanoliposomes exceeds 70 nm, the promotion of transdermal absorption is very weak among the technical effects to be achieved in the present invention.

According to a preferred embodiment of the present invention, the content of the nanoliposomes is 0.1-20.0% by weight, preferably 1.0-10.0% by weight relative to the total weight of the composition. In addition, the content of caffeine is 1.0-30.0% by weight, preferably 3.0-20.0% by weight relative to the total weight of the nanoliposomes.

According to a preferred embodiment of the present invention, the nanoliposomes of the present invention comprise (i) an oily component comprising polyol, (ii) ceramide and cholesterol, (iii) surfactant, (iii) phospholipid, (iii) fatty acid and (iii) It is prepared by a mixture containing water, characterized in that the mixture does not contain a monohydric alcohol.

The polyol used in the nanoliposome of the present invention is not particularly limited, and preferably, propylene glycol, dipropylene glycol, 1,3-butylene glycol, glycerin, methyl propanediol, isoprene glycol, pentylene glycol, erythritol, xyitol, Sorbitol and mixtures thereof. It is preferably selected from the group consisting of propylene glycol, 1,3-butylene glycol, glycerin and mixtures thereof, most preferably glycerin. The amount used is 10-80% by weight, preferably 30-70% by weight based on the total weight of the nanoliposomes.

The oil component used in the preparation of the nanoliposomes of the present invention may be various oils known in the art, preferably hydrocarbon-based oils such as hexadecane and paraffin oil in addition to ceramide and cholesterol; Synthetic synthetic oils; Silicone oils such as dimethicone and cyclomethicone series; Animal and vegetable oils such as sunflower oil, corn oil, soybean oil, avocado oil, sesame oil, jojoba oil, squalane and fish oil; Ethoxylated alkyl ether oils; Propoxylated alkyl ether oils; Sphingoidoid lipids such as phytosphingosine, sphingosine and sphinginine; Cerebroside; Cytosterol; Cholesteryl sulfate; One selected from the group consisting of _cytosteryl sulfate and C _10-40 fatty alcohol. More preferably the oily component is a mixture of ceramide, cholesterol and animal and vegetable oils (jojoba oil, squalane and the like). The amount used is 1.0-30.0% by weight, preferably 3.0-20.0% by weight based on the total weight of nanoliposomes. On the other hand, the ceramides used in the present invention preferably include all kinds of ceramides of type 1-6, more preferably ceramide type 3.

Surfactants used in the preparation of the nanoliposomes of the present invention can be used in the art known in the art, for example, from the group consisting of alkylacylglutamate, alkyl phosphate, alkyl lactylate, dialkyl phosphate and trialkyl phosphate Selected anionic surfactants or nonionic surfactants selected from the group consisting of alkoxylatedalkylethers, alkoxylatedalkylesters, alkylpolyglycosides, polyglyceryl esters and sugar esters, most preferably nonionic Polysorbates belonging to the surfactant are used. The amount of the surfactant to be used is generally 0.1-10% by weight, preferably 0.2-3.0% by weight based on the total weight of the nanoliposomes.

Phospholipids, another component used in the preparation of the nanoliposomes of the present invention, are used as amphoteric lipids, including natural phospholipids (eg, egg yolk lecithin or soy lecithin, sphingomyelin) and synthetic phospholipids (eg dipalmitoyl). Phosphatidylcholine or hydrogenated lecithin), preferably lecithin. More preferably, the lecithin is naturally occurring unsaturated lecithin or saturated lecithin extracted from soybean or egg yolk. Typically, lecithin derived from nature has 23-95% phosphatidyl choline and 20% or less phosphadidylethanolamine. In the preparation of the nanoliposomes of the present invention, the amount of lecithin used is 0.5-20.0% by weight, preferably 2.0-10.0% by weight, based on the total weight of the nanoliposomes.

The fatty acids used in the preparation of the nanoliposomes of the present invention are higher fatty acids, preferably saturated or unsaturated fatty acids of a C _12-22 alkyl chain, such as lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid, linoleic acid. And palmilean acid, more preferably is selected from the group consisting of stearic acid, palyoleic acid and mixtures thereof. In the preparation of the nanoliposomes of the present invention, the amount of fatty acids used is 0.05-5.0% by weight, preferably 0.1-4.0% by weight relative to the total weight of nanoliposomes.

Water used for the preparation of the nanoliposomes of the present invention is generally deionized distilled water, the amount of which is used is 5.0-40% by weight relative to the total weight of nanoliposomes.

Nanoliposomes of the present invention may further comprise emollients and most preferably include caprylic / capric triglycerides. The content is 1.0-15.0 wt%, preferably 3.0-7.0 wt%. In addition, the nanoliposomes of the present invention may optionally comprise small amounts (about 0.5-1.0% by weight) of emulsions (eg, sodium stearoyl lactate).

The preparation of nanoliposomes can be accomplished through various methods known in the art, but most preferably, a mixture comprising the above components is applied to a high pressure homogenizer. The preparation of nanoliposomes by high pressure homogenizer can be carried out under various conditions (eg pressure, frequency, etc.) depending on the desired particle size, preferably 1-5 times high pressure homogenizer under 600-1200 bar pressure. Nanoliposomes are prepared by passing through.

The nanoliposome thus prepared has the advantage of maximizing the skin penetration effect of the active ingredient by stabilizing unstable substances while simultaneously dissolving various types of poorly soluble substances.

Another feature of the present invention is to promote the subcutaneous fat delivery of caffeine by applying the nano-liposomes, the microemulsified particles to the lamellar gel network liquid crystal (hydrosome) having a structure similar to the lamellar structure of the stratum corneum.

Hydrosomes generally refer to formulation systems in which a Lamellar gel network liquid crystal is formed in a continuous phase in an oil-in-water emulsion.

Liquid crystal is an intermediate state between a liquid and a solid or crystal. The liquid crystal is liquid, but has birefringence and anisotropy, which are properties of crystals.

There are two types of liquid crystals: thermotropic type and lyotropic type. The former is controlled by the temperature in the solvent and the latter is controlled by the concentration of the emulsifier in the solvent.

In particular, the plastic-induced liquid crystal can be classified into a cubic phase, a lamellar phase, a hexagonal phase, and the like according to the type and concentration of the emulsifier used. Similar to the double membrane structure, it is known to assist in the transport and sustained release of the active substance.

The present inventors found that when the nanoliposome encapsulated in caffeine is used in cosmetics, it is significantly promoted percutaneous absorption of caffeine when used as a lamellar gel network liquid crystal formulation formed using emulsifiers sorbitan stearate and sorbitol laurate. Found.

According to a preferred embodiment of the present invention, the emulsifiers used to form the hydrosomes are sorbitan stearate and sorbitan laurate.

According to a preferred embodiment of the present invention, the ratio of sorbitan stearate and sorbital laurate is 0.1: 1 to 1: 0.1, most preferably 1: 1.

According to a preferred embodiment of the present invention, the amount of sorbitan stearate and sorbitan laurate used is 0.01-10.0% by weight, more preferably 0.1-4.0% by weight, based on the total weight of the composition.

The term "hydrosome" in the present invention means that the lamellae form a network in the form of a gel on the water phase in the continuous phase.

In preparing a composition having a hydrosome formulation system of the present invention, it is characterized by using sorbitan stearate & sorbital laurate as the emulsifier, but not necessarily limited to the emulsifier, various of similar functions known in the art Emulsifiers may be used.

According to a preferred embodiment of the present invention, the amount of emulsifier used is 0.01-10.0% by weight, more preferably 0.1-4.0% by weight, based on the total weight of the composition.

The components included in the slimming cosmetic composition of the present invention include components conventionally used in cosmetic compositions, in addition to nanoliposomes stabilized by inclusion of caffeine as an active ingredient, and include, for example, conventional agents such as stabilizers, solubilizers, vitamins, pigments and perfumes. Phosphorus aids, and carriers.

The slimming cosmetic composition of the present invention may be prepared in any formulation commonly prepared in the art, for example, solutions, suspensions, emulsions, pastes, gels, creams, lotions, powders, soaps, surfactant-containing It may be formulated as cleansing, oil, powder foundation, emulsion foundation, wax foundation, spray, and the like, but is not limited thereto. More specifically, it may be prepared in the form of a flexible lotion, nutrition lotion, nutrition cream, massage cream, essence, eye cream, cleansing cream, cleansing foam, cleansing water, pack, spray or powder.

When the formulation of the present invention is a paste, cream or gel, animal oils, vegetable oils, waxes, paraffins, starches, trachants, cellulose derivatives, polyethylene glycols, silicones, bentonites, silicas, talc or zinc oxide may be used as carrier components. Can be.

When the formulation of the present invention is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used, in particular in the case of a spray, additionally chlorofluorohydrocarbon, propane Propellant such as butane or dimethyl ether.

When the formulation of the present invention is a solution or emulsion, a solvent, solubilizer or emulsifier is used as the carrier component, such as water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1 Fatty acid esters of, 3-butylglycol oil, glycerol aliphatic ester, polyethylene glycol or sorbitan.

When the formulation of the present invention is a suspension, liquid carrier diluents such as water, ethanol or propylene glycol, suspending agents such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol esters and polyoxyethylene sorbitan esters, Crystalline cellulose, aluminum metahydroxy, bentonite, agar or tracant and the like can be used.

When the formulation of the present invention is a surfactant-containing cleansing, the carrier component is an aliphatic alcohol sulfate, an aliphatic alcohol ether sulfate, a sulfosuccinic acid monoester, isethionate, an imidazolinium derivative, a methyltaurate, a sarcosinate, a fatty acid amide. Ether sulfates, alkylamidobetaines, aliphatic alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, lanolin derivatives or ethoxylated glycerol fatty acid esters and the like can be used.

According to the present invention, caffeine having excellent lipolysis effect is included in a nanoliposomal and stabilized, and subcutaneous fat delivery of caffeine is promoted by applying the fine emulsified particles to a hydrosome having a structure similar to the lamellar structure of the stratum corneum. In addition, the slimming cosmetic composition of the present invention by promoting the percutaneous absorption of caffeine is excellent in subcutaneous fat decomposition effect, cellulite removal effect and elasticity promoting effect of fat cells.

Hereinafter, the present invention will be described in more detail with reference to Examples. These examples are only for explaining the present invention in more detail, and the scope of the present invention is not limited by these examples in accordance with the gist of the present invention belonging to the present invention. It will be obvious to him.

Preparation Example: Preparation of Stabilized Nanoliposomes by Inclusion of Caffeine

Nanoliposomes encapsulated with caffeine were prepared with the composition shown in Table 1 below, and the preparation method was as follows: First, phase B was added to phase A, uniformly wetted, phase C was added to phase AB, and then 70- The mixture was heated to 77 ° C. and stirred uniformly. Subsequently, the mixture was passed through a high pressure homogenizer (Microfluidizer M-110F, Microfluidics International Corporation) 1-5 times under conditions of 600-1,200 bar and cooled to obtain nanoliposomes having a particle size of 30-70 nm in diameter (Preparation Example 1 -5) was prepared.

Prize ingredient Content (% by weight) Preparation Example 1 Preparation Example 2 Preparation Example 3 Preparation Example 4 Preparation Example 5 A Caffeine 10.0 10.0 10.0 10.0 10.0 glycerin 60.0 0.0 0.0 0.0 15.0 1,3-butylene glycol 0.0 60.0 0.0 0.0 15.0 Propylene glycol 0.0 0.0 60.0 0.0 15.0 Dipropylene glycol 0.0 0.0 0.0 60.0 15.0 B lecithin 5.0 5.0 5.0 5.0 5.0 Hydrogenated Lecithin 3.0 3.0 3.0 3.0 3.0 Ceramide 3 4.0 4.0 4.0 4.0 4.0 Palmitic Oleic Acid 1.0 1.0 1.0 1.0 1.0 Caprylic / Capric Triglycerides 5.0 5.0 5.0 5.0 5.0 Jojoba oil 1.0 1.0 1.0 1.0 1.0 Squalane 1.0 1.0 1.0 1.0 1.0 Sodium stearoyl lactate 0.5 0.5 0.5 0.5 0.5 Polysorbate-80 0.5 0.5 0.5 0.5 0.5 C Potassium hydroxide Quantity Quantity Quantity Quantity Quantity Purified water To 100 To 100 To 100 To 100 To 100

Example 1 and Comparative Example 1-5: Preparation of Slimming Cosmetic Composition

In the case of using the liposome stabilized by inclusion of caffeine in the lamella gel network liquid-type hydrosome formulation system, the emulsion was analyzed to examine the effects of caffeine on the fat cell subcutaneous fat breakdown effect, cellulite removal effect and elasticity enhancement effect. The composition of the formulation was prepared as follows.

To the hydrosomal emulsion formulation composition comprising the nanoliposomes stabilized by inclusion of caffeine in the composition of Table 2 (Example 1), general emulsion formulation (Comparative Example 1), hydrosome emulsion formulation (Comparative Example 2), caffeine General emulsion formulation composition comprising (Comparative Example 3), General emulsion formulation composition comprising nanoliposomes stabilized by inclusion of caffeine (Comparative Example 4), hydrosome emulsion formulation composition comprising caffeine (Comparative Example 5 ) Was prepared.

Nanoliposomes stabilized by inclusion of the caffeine of Example 1 and Comparative Example 4 were used nanoliposomes of Preparation Example 1.

ingredient Example 1 Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Comparative Example 5 Content (% by weight) Content (% by weight) Content (% by weight) Content (% by weight) Content (% by weight) Content (% by weight) Nanoliposomes stabilized by inclusion of caffeine 5.0 - - - 5.0 - Caffeine - - - 0.5 - 0.5 Polysorbate-60 - 1.5 - 1.5 1.5 - Sorbitan stearate - 1.0 - 1.0 1.0 - Sorbitan stearate & sorbitan laurate 2.0 - 2.0 - - 2.0 Squalane 3.0 3.0 3.0 3.0 3.0 3.0 Isopropyl myristate 2.0 2.0 2.0 2.0 2.0 2.0 Carbomer 0.2 0.2 0.2 0.2 0.2 0.2 Potassium hydroxide 0.1 0.1 0.1 0.1 0.1 0.1 antiseptic Quantity Quantity Quantity Quantity Quantity Quantity Spices a very small amount a very small amount a very small amount a very small amount a very small amount a very small amount Purified water to 100 to 100 to 100 to 100 to 100 to 100

Experimental Example 1: Measurement of the stability of the formulation

Caffeine was stabilized by inclusion in nanoliposomes, and stability tests were performed on the composition in which the nanoliposomes were applied to a hydrosome formulation system having a structure similar to the lamellar structure of the stratum corneum.

To test the stability of the formulations, the emulsion formulations of Example 1 and Comparative Examples 1-5 prepared above were stored in an opaque vitreous container in a thermostat maintained at room temperature and 45 ° C. for 12 weeks, and further stored at 4 ° C. In a completely shaded refrigerator kept constant as a opaque glass jar was stored for 12 weeks and then measured for the degree of discoloration / deodorization, separation. The results are summarized in Table 3 below. At this time, the degree of product discoloration / odor / separation was evaluated by classifying into the following six grades.

<Production degree of crystallization>

0: no change. 1: very little discoloration / odor / separation.

2: a little discoloration / odor / separation. 3: Slightly discolored / deodorized / separated.

4: Severe discoloration / odor / separation. 5: Extremely severe discoloration / odor / separation.

Temperature Discoloration / deodorization / separation degree Example 1 Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Comparative Example 5 45 ℃ 0 0 0 0 0 0 Room temperature 0 0 0 0 0 0 4 ℃ 0 0 0 0 0 0

As can be seen in Table 3, the compositions of Example 1 and Comparative Examples 1-5 were all stable without discoloration / deodoration / separation under all temperature conditions.

Experimental Example 2: Transdermal Absorption Measurement Test

Transdermal absorption of caffeine was measured using Franz permeable cells in hairless mouse skin. Before the test, the abdominal skin of male and female hairless mice of 5 to 8 weeks old was taken and cut into square 1 cm 2 areas, which were placed in a transmission cell having a diameter of 0.64 cm 2 and clamped. One side of the skin (donor container) was added with 0.5 g of Example 1 and Comparative Example 3-5 above. The opposite side (receptor container) was allowed to come in contact with phosphate buffer and the temperature at the test was maintained at 32 ° C., the actual skin temperature. After the start of the test, a portion of the solvent was collected at regular time intervals, and then the amount of caffeine penetrated through the skin was measured using HPLC, and expressed as the skin permeation amount (µg / cm 2 / wt%) per application concentration. It is shown in Table 4 below.

division Elapsed time (hrs) 0 4 8 12 24 Example 1 0 2.41 5.02 7.24 15.92 Comparative Example 3 0 0.89 1.71 2.46 4.99 Comparative Example 4 0 1.32 2.76 4.16 9.03 Comparative Example 5 0 1.25 2.64 4.05 8.87

Through the results of Table 4, in the case of a hydrosome formulation composition (Example 1) comprising nanoliposomes stabilized by inclusion of caffeine, the composition is applied to the general emulsion formulation (Comparative Example 3), caffeine by It was confirmed that the caffeine transdermal absorption was very superior to the composition in which the stabilized nanoliposomes were applied to a general emulsion formulation (Comparative Example 4) and the composition in which caffeine was applied to the hydrosome formulation (Comparative Example 5). These results can be seen to be very high compared to the values shown in Comparative Examples 3-5. The results indicate that when the nanoliposomes stabilized by inclusion of caffeine are prepared in a hydrosome emulsion formulation, transdermal absorption of caffeine can be improved in high yield.

Experimental Example 3: Clinical Effect Test on Anti-Cellulite Effect

The anti-cellulite effect on each composition of Example 1 and Comparative Example 1-5 was measured.

For female subjects over 30 years of age who had obesity symptoms on their thighs, each composition of Example 1 and Comparative Example 1-5 was formulated according to Table 2, and a sufficient amount of thighs twice a day was 12 Weekly application was performed to determine the anti-cellulite effect. However, the subjects who participated in this experiment were managed to maintain a regular life and a regular diet during the test period. As a measuring method, a reduced length (ΔL = L ₀ -L ₁₂ ) was measured using a ruler. The results of this experiment are shown in Table 5 below.

division Thigh circumference change (cm) L ₀ L ₁₂ △ L Example 53.4 50.1 -3.3 Comparative Example 1 53.2 53.0 -0.2 Comparative Example 2 50.5 50.6 +0.1 Comparative Example 3 50.7 49.3 -1.4 Comparative Example 4 55.2 53.0 -2.2 Comparative Example 5 55.6 53.6 -2.0

Looking at the results of Table 5, in the case of the composition containing no caffeine (Comparative Examples 1, 2) little change in thigh circumference was observed, the hydrosome formulation composition comprising a nanoliposome stabilized by inclusion of caffeine ( Example 1) showed the best anti-cellulite effect. At this time, the weight of the subject did not change during the test period.

Experimental Example 4: Survey evaluation on the elasticity promoting effect

All women volunteers who participated in the experiment of Experimental Example 3 was subjected to a questionnaire evaluation on the elasticity enhancing effect during the test period. The results are summarized in Table 6 below. At this time, the degree of elasticity improvement was classified into five grades and evaluated.

<Elasticity level grade>

-2: very resilient.

-1: slightly reduced elasticity.

 0: No change in elasticity.

 1: slightly enhanced elasticity.

 2: very promote elasticity.

division Elasticity improvement degree Example 1 Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Comparative Example 5 Survey Evaluation 1.6 0.2 0.2 0.6 1.1 1.0

In the case of the caffeine-free composition (Comparative Examples 1 and 2) from the results of Table 6, the elasticity-promoting effect was hardly observed, and the hydrosome-type formulation composition comprising the nanoliposomes stabilized by inclusion of caffeine ( Example 1) was confirmed to exhibit the most excellent elasticity promoting effect.

From the above results, in the case of a slimming cosmetic composition in which the nanoliposome stabilized by inclusion of caffeine having excellent lipolysis effect was applied to the hydrosome gelling system, the percutaneous absorption of caffeine was increased, and subcutaneous fat decomposition effect of cell was removed and cellulite removal effect. And it can be seen that the elasticity promoting effect is very excellent.

Based on the results of the experimental example described above, a caffeine having excellent lipolysis effect is included in the nanoliposomes to stabilize and present the slimming cosmetic composition applying the microemulsion particles to a hydrosome system having a structure similar to the lamellar structure of the stratum corneum. do. However, the slimming cosmetic composition of the present invention is not limited to the following formulation examples.

Formulation Example 1: Softener (Skin Lotion)

To the flexible composition and the content shown in Table 7 was prepared according to a conventional method.

Compounding ingredient Content (% by weight) Caffeine Nanoliposomes (Preparation Example 1) 1.0 1.3-butylene glycol 6.0 glycerin 4.0 Oleyl alcohol 0.1 Sorbitan stearate & sorbitan laurate 0.5 ethanol 15.0 Benzophenone-9 0.05 Incense, preservative a very small amount Purified water to 100

Formulation Example 2: Nutrients (Milk Lotion)

The nutritional longevity was prepared according to a conventional method with the composition and content shown in Table 8.

Compounding ingredient Content (% by weight) Caffeine Nanoliposomes (Preparation Example 1) 3.0 Propylene glycol 6.0 glycerin 4.0 Triethanolamine 1.2 Tocophenyl Acetate 3.0 Liquid paraffin 5.0 Squalane 3.0 Macadamia Nut Oil 2.0 Sorbitan stearate & sorbitan laurate 2.0 Carboxyvinyl Polymer 1.0 BHT 0.01 EDTA-2Na 0.01 Incense, preservative a very small amount Purified water to 100

Formulation Example 3: Nutrition Cream

The nutrition cream was prepared in a conventional manner with the composition and content shown in Table 9.

Compounding ingredient Content (% by weight) Caffeine Nanoliposomes (Preparation Example 1) 10.0 Cetostearyl alcohol 2.0 Glyceryl Stearate 1.5 Trioctanoine 5.0 Sorbitan stearate & sorbitan laurate 2.0 Squalane 5.0 Floating paraffin 3.0 Cyclomethicone 3.0 BHT 0.05 Delta-tocopherol 0.2 Concentrated glycerin 4.0 1,3-butylene glycol 2.0 Santa sword 0.1 EDTA-2Na 0.05 Incense, preservative a very small amount Purified water to 100

Formulation Example 4: Massage Cream

A massage cream was prepared according to a conventional method with the composition and content shown in Table 10 below.

Compounding ingredient Content (% by weight) Caffeine Nanoliposomes (Preparation Example 1) 1.0 Propylene glycol 6.0 glycerin 4.0 Triethanolamine 0.5 Beeswax 2.0 Tocopheryl Acetate 0.1 Sorbitan stearate & sorbitan laurate 4.0 Cetearyl Alcohol 2.0 Liquid paraffin 30.0 Carboxy Vinyl Polymer 0.5 Incense, preservative a very small amount Purified water to 100

As described in detail above, the present invention provides a slimming cosmetic composition of a hydrosome formulation comprising nanoliposomes stabilized by inclusion of caffeine. Slimming cosmetic composition of the present invention is stabilized by inclusion of caffeine excellent in lipolysis effect to the nanoliposomes, hydrophobic having a structure similar to the lamellar structure of the stratum corneum, further promoting subcutaneous fat delivery of caffeine This is very useful for subcutaneous fat breakdown, cellulite removal and elasticity of fat cells.

Having described the specific part of the present invention in detail, it is apparent to those skilled in the art that the specific technology is merely a preferred embodiment, and the scope of the present invention is not limited thereto. Thus, the substantial scope of the present invention will be defined by the appended claims and equivalents thereof.

Claims (8)

Slimming cosmetic composition of a hydrosome formulation comprising a nanoliposome stabilized by inclusion of caffeine. 2. The composition of claim 1, wherein the composition exhibits the action of (i) promoting transdermal absorption of caffeine, (ii) subcutaneous fat degradation of adipocytes, (i) removing cellulite, (i) enhancing elasticity, or (i) a combination thereof. Slimming cosmetic composition, characterized in that. The slimming cosmetic composition according to claim 1, wherein the content of the nanoliposome is 0.1-20.0 wt% based on the total weight of the composition. The slimming cosmetic composition according to claim 1, wherein the content of caffeine is 1.0-30.0 wt% based on the total weight of the nanoliposomes. The slimming cosmetic composition according to claim 1, wherein the hydrosome is formed using an emulsifier. The slimming cosmetic composition according to claim 5, wherein the emulsifier is included in an amount of 0.01-10.0 wt% based on the total weight of the composition. The slimming cosmetic composition according to claim 5 or 6, wherein the emulsifier is sorbitan stearate and sorbital laurate. The composition of claim 1 wherein the cosmetic composition consists of a solution, suspension, emulsion, paste, gel, cream, lotion, powder, soap, surfactant-containing cleansing, oil, powder foundation, emulsion foundation, wax foundation and spray Slimming cosmetic composition, characterized in that it has a formulation selected from the group.