CN108703941A - A kind of lotion, preparation method and application with the very thin effect of four limbs - Google Patents
A kind of lotion, preparation method and application with the very thin effect of four limbs Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
- A61K8/068—Microemulsions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9706—Algae
- A61K8/9717—Rhodophycota or Rhodophyta [red algae], e.g. Porphyra
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- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/06—Preparations for care of the skin for countering cellulitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
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Abstract
The invention discloses a kind of lotion, preparation method and applications with the very thin effect of four limbs, are related to cosmetic technical field.The lotion with the very thin effect of four limbs, raw material include active component, water, oil, emulsifier, organic solvent and function additive；Wherein, active component includes caffeine, hazelnut oil, sunflower seed oil, butcher's broom root extract, hydroiodic acid TEA salt, carnitine, Ba 2672, foreign hederae folium/stem extraction, tripeptides 1, bacillus or fermented soybean product extract, Chondrus crispus extract and carbohydrate isomer.The preparation method of the lotion, method is simple, and obtained lotion can be used widely in reducing fat, and has good fat-reducing effect to four limbs and abdomen.
Description
Technical field
The present invention relates to cosmetic technical fields, and more particularly to a kind of lotion with the very thin effect of four limbs, its preparation
Method and application.
Background technology
Type of latex type cosmetics, the mainly emulsification system of oil-in-water type can supplement moisture of skin, moisturize the skin, are one
The common cosmetics type of kind.Produce lotion in the prior art, controlling of production process point is more, especially be added various active at
Point, there is prodigious test to entire emulsion system.The temperature of emulsification, mechanical force, time, the addition of interior foreign minister and emulsifier are suitable
Sequence etc. can all influence emulsion intercalation method, can not achieve the desired results so as to cause product.
The problems of the prior art are mainly manifested in following：(1) selection of emulsifier is unreasonable, causes lotion to stick greasy, thick
It is rough, Submicron Emulsion cannot be formed；(2) lotion can not carry a variety of active ingredients, lead to the generation of demulsifying phenomenon；(3) work can not be made
Property ingredient plays expected effect.
Invention content
The purpose of the present invention is to provide a kind of lotions with the very thin effect of four limbs, it is intended to decompose limb fat.
Another object of the present invention is to provide a kind of preparation methods of lotion, and method is simple, are suitable for industrialization
Using.
The third object of the present invention is to provide application of the above-mentioned emulsion in reducing fat.
The present invention solves its technical problem using following technical scheme to realize.
The present invention proposes a kind of lotion with the very thin effect of four limbs, and raw material includes active component, water, oil, breast
Agent, organic solvent and function additive；
Wherein, active component include caffeine, hazelnut oil, sunflower seed oil, butcher's broom root extract, hydroiodic acid TEA salt,
Carnitine, Ba 2672, foreign hederae folium/stem extraction, tripeptides 1, bacillus or fermented soybean product extract, ripple angle
Pitch dish extract and carbohydrate isomer.
The present invention also proposes the preparation method of lotion, includes the following steps：
The first mixture is obtained after water, moisturizer, thickener and organic solvent are mixed；
First mixture and oil, emulsifier and assistant for emulsifying agent are mixed to get the second mixture；
Second mixture and active component, preservative, freshener and essence are mixed to get third mixture；
Preferably, the mixing temperature in the preparation process of the first mixture is 80-85 DEG C.
Application of the lotion that the preparation method of above-mentioned emulsion is prepared in reducing fat.
The embodiment of the present invention provides a kind of advantageous effect of the lotion with the very thin effect of four limbs：It passes through in formula
The selection of active component specifically includes caffeine, hazelnut oil, sunflower seed oil, butcher's broom root extract, hydroiodic acid TEA salt, meat
Alkali, Ba 2672, foreign hederae folium/stem extraction, tripeptides 1, bacillus or fermented soybean product extract, ripple angle fork
Dish extract and carbohydrate isomer.The active matter added in lotion is a kind of proliposome, is made using the collaboration of each component
Obtained compound is squeezed out by multiple with three peptide materials for making to be formed, once it is added in lotion, this proliposome ingredient
Ensure the formation of liposome.The formula provided in the embodiment of the present invention can play the role of significantly decomposing limb fat,
It is suitable for promoting and applying.
The present invention also provides a kind of preparation methods of lotion, and method is simple, and obtained lotion can divide
It is used widely in solution fat.
Description of the drawings
In order to illustrate the technical solution of the embodiments of the present invention more clearly, below will be to needed in the embodiment attached
Figure is briefly described, it should be understood that the following drawings illustrates only certain embodiments of the present invention, therefore is not construed as pair
The restriction of range for those of ordinary skill in the art without creative efforts, can also be according to this
A little attached drawings obtain other relevant attached drawings.
Fig. 1 is that macroscopic fold of subject's arm reflects picture；
Fig. 2 is subject's digital pictures.
Specific implementation mode
It in order to make the object, technical scheme and advantages of the embodiment of the invention clearer, below will be in the embodiment of the present invention
Technical solution be clearly and completely described.The person that is not specified actual conditions in embodiment, builds according to normal condition or manufacturer
The condition of view carries out.Reagents or instruments used without specified manufacturer is the conventional production that can be obtained by commercially available purchase
Product.
The lotion to provided in an embodiment of the present invention with the very thin effect of four limbs, preparation method and application have below
Body explanation.
A kind of lotion with the very thin effect of four limbs provided in an embodiment of the present invention, raw material includes active component, water, oil
Point, emulsifier, organic solvent and function additive.
Wherein, active component include caffeine, hazelnut oil, sunflower seed oil, butcher's broom root extract, hydroiodic acid TEA salt,
Carnitine, Ba 2672, foreign hederae folium/stem extraction, tripeptides 1, bacillus or fermented soybean product extract, ripple angle
Pitch dish extract and carbohydrate isomer.
Specific introduction is done to main active constituent below.
Bacillus/fermented soybean product extract is obtained from most low multicellular animals sponge.Positioned at north
The subtropical island in the Atlantic Ocean possesses the grand coastlines nearly 120km, sandy beach and mirable limpid seawater, also abundant
Coral reef, sea grass bed, mangrove swamp, underwater cave and various multicellular animals.Sponge (Sponge) be exactly wherein it
One.Sponge (Sponge) structure is simpler, but contains profuse bioactive substance as a special biocenose.We
Bacillus micro-organism has been isolated from sponge.Bacillus micro-organism can generate a large amount of metabolin to adjust difference
Various metabolic pathways in the ecosystem.
Caffeine decomposes triglyceride by the effect stimulation solution fat on AMPc (cyclic annular adenylic acid) level；Together
When it also have angiectatic characteristic, accelerate blood flow.Therefore, it works in terms of solution fat and vascular stimulation two.
Butcher's broom root extract mainly works in microcirculation, capillary percolation is reduced, because in this extract
Flavonoid substances containing referred to as rutin sophorin.The effect of hydroiodic acid TEA salt is by stimulating lipase to play solution fat.Ivy is extracted
Object contains hederin, is to play a part of to protect blood vessel and reduce a kind of active saponin of infiltration, ivy extract helps
Reabsorb the edema that initial period appearance is formed in cellulite.
In addition, carnitine can promote the movement of triglyceride and accelerate its decomposition；Horse chestnut in Ba 2672
Escin is a kind of vascular stimulation and the swollen ingredient of anti-floating.Hazelnut oil is wood-nut (CORYLUS AVELLANA) seed oil, can
To be suitable for various skin quality, based on oil use, cytothesis, stimulation cycle can be stimulated.1 English name of tripeptides is
TRIPEPTIDE-1 is a kind of corium growth-promoting factors.
Chondrus crispus extract is the moisturizing ingredient extracted from natural seaweed, can help skin improve water content and
Moisturizing degree.Carbohydrate isomer common are D-Glucose, L- glucose, D-Fructose, D-MANNOSE, D- idoses, D- half
Lactose etc. is a kind of good moisturizer and emollients, has and repair epidermal layer cells, promotes skin moisturizing ability.
It should be noted that the active matter added in lotion is a kind of proliposome, made using the synergistic effect of each component
Three peptide materials formed squeeze out obtained compound by multiple, once being added in lotion, this proliposome ingredient ensures
The formation of liposome.The formula provided in the embodiment of the present invention can play the role of significantly decomposing limb fat, this master
If due to the synergistic effect of its active constituent.
The content that inventor provides each component in formula for the embodiment of the present invention is defined, in parts by weight
Meter, the raw material of lotion includes 0.8-1.3 parts of caffeine, 0.3-0.8 parts of hazelnut oil, 0.6-1.0 parts of sunflower seed oil, phyllodium tree root
1.5-2.5 parts of extract, 0.3-0.8 parts of hydroiodic acid TEA salt, 0.8-1.3 parts of carnitine, 0.8-1.3 parts of Ba 2672, ocean Chang Chun
Cane leaves/1.5-2.5 parts of stem extraction, -1 0.3-0.8 parts of tripeptides, bacillus or fermented soybean product extract 0.5-1.5
Part, 0.5-1.5 parts of Chondrus crispus extract, 0.1-0.3 parts of carbohydrate isomer, 45-55 parts of water, 8-15 parts of oil, breast
14-25 parts of 2-4 parts of agent, 3-5 parts of organic solvent and function additive.
Preferably, the raw material of lotion includes 0.9-1.2 parts of caffeine, 0.4-0.7 parts of hazelnut oil, sunflower seed oil 0.7-
0.9 part, 1.8-2.2 parts of butcher's broom root extract, 0.4-0.6 parts of hydroiodic acid TEA salt, 0.9-1.2 parts of carnitine, Ba 2672
0.9-1.2 parts, foreign hederae folium/1.8-2.2 parts of stem extraction, -1 0.4-0.6 parts of tripeptides, bacillus or fermented soybean production
0.8-1.2 parts of object extract, 0.8-1.2 parts of Chondrus crispus extract, 0.1-0.3 parts of carbohydrate isomer, water 48-52
Part, 9-13 parts of oil, 2-3 parts of emulsifier, 3.5-4.5 parts of organic solvent and 17-22 parts of function additive.
Inventor has found that the proportioning of active component plays an important roll lipolytic effect promoting in formula,
Dosage can lead to the decline of lipolysis effect beyond above range, or side effect is caused to dramatically increase.
Further, function additive include 14-20 parts of moisturizer, it is 0.3-0.8 parts of thickener, 0.3-0.6 parts of preservative, clear
Cool dose 0.03-0.06 parts, 0.1-0.2 parts of essence, 1.5-2.5 parts of assistant for emulsifying agent.On the one hand the selection of function additive is to ensure breast
Change effect, so that active constituent is more stablized in system, while skin sense is clearly smooth.
Specifically, any one of moisturizer in butanediol, methyl gluceth 20, glycerine and 1,3-PD
Or it is several.Thickener is selected from xanthans, acrylic acid (ester) analog copolymer sodium, acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters
Any one or a few in cross-linked polymer.Assistant for emulsifying agent is Natrulon H-10 stearate.It is above several in other embodiments
Kind auxiliary agent is not limited to the component enumerated, but auxiliary agent can make the stability of whole system stronger using above several components.
Specifically, emulsifier is cetostearyl alcohol ethylhexoate and/or polyglycereol-3-methyl distearate.Hair
A person of good sense has found that emulsifier uses any one or two kinds of combinations in both the above component, can play good emulsification
Effect is to ensure active material in system an important factor for stability.
Specifically, organic solvent is selected from alcohols, esters or ethers, preferably alcohols, more preferably ethyl alcohol.Organic solvent is adopted
Common solvents in being prepared with general lotion, wherein being advisable using ethyl alcohol.
Specifically, oil is selected from neopentyl glycol two (thylhexoic acid) ester, Nexbase 2004 and one kind or more in lecithin
Kind；Preferably, oil includes 4-6 parts of (thylhexoic acid) ester of neopentyl glycol two, 4-6 parts of Nexbase 2004 and lecithin 0.8-1.2
Part.The selection of oil there is great influence, inventor to find oil using above several components the stability of whole system
Coordinate with active component, makes the stability higher of whole system, be conducive to persistently efficiently use active matter.
The embodiment of the present invention additionally provides a kind of preparation method of lotion, includes the following steps：
S1, water phase mixing
The first mixture is obtained after water, moisturizer, thickener and organic solvent are mixed；Preferably, in the first mixture
Preparation process in mixing temperature be 80-85 DEG C.
Specifically, the deionized water that blending water is formed from reverse osmosis unit, water phase are blended in water phase pot and carry out,
80-85 DEG C of stirring is to being completely dissolved.
S2, oil mixing with water
First mixture and oil, emulsifier and assistant for emulsifying agent are mixed to get the second mixture.Specifically, the second mixing
The preparation process of object includes：After oil, emulsifier and assistant for emulsifying agent are mixed under 80-85 DEG C of temperature condition, then with
One mixture mixing 5-10min.By the way of being mixed again with the first mixture after first mixing oil and emulsifier, it can make
Emulsifying effectiveness is more preferable, the emulsion intercalation method higher of formation.
In addition, this step mixed process carries out in emulsifying pot, stirring is needed to keep the temperature in mixed process.
S3, active material mixing
Second mixture and active component, preservative, freshener and essence are mixed to get third mixture.Preferably,
Include in the preparation process of third mixture：After second mixture is cooled to 45-50 DEG C, then with active component, preservative,
Freshener and essence mix, and 10-14h is stood after filtering and discharging.
Preferably, active material, which ultimately joins, can coordinate Submicron Emulsion technology, make each component grain size smaller, improve active matter
The rate of dissolution and solubility of matter are conducive to the bioavilability for improving slightly solubility active constituent；Improve in use and lives
The stability of property ingredient in vivo and in vitro, is conducive to persistently effectively utilize active matter.Specifically, promoted by sub-micro dispersion technology
The homogenizing of active constituent in mixed system, obtains the particle of grain size very little, to be conducive to the formation of special liposome.These are special
Different liposome ensures effective infiltration of active constituent so that active matter can reach the bottom of epidermis.
In some embodiments the colors auxiliary agent such as CI 17200 can be added when third is walked and mixed, so as to get product
Color is more preferable.
The lotion that the embodiment of the present invention is prepared can be applied to the lipolysis of four limbs, reach the very thin effect of four limbs
Fruit can coordinate liposome conduction technique and high pressure microfluidic technology in application process.As the compounding of above-mentioned active constituent is tied again
Close special liposome conduction technique so that these activating agents can penetrate into the basal layer of human epidermal, more effectively to anti-grease
Fat group.
The feature and performance of the present invention are described in further detail with reference to embodiments.
Embodiment 1
The present embodiment provides a kind of lotion with the very thin effect of four limbs, raw material includes 0.8 part of caffeine, hazelnut oil
0.3 part, 0.6 part of sunflower seed oil, 1.5 parts of butcher's broom root extract, 0.3 part of hydroiodic acid TEA salt, 0.8 part of carnitine, horse chestnut soap
0.8 part of glycosides, foreign 1.5 parts of ivy extract, 0.3 part of tripeptides -1,0.5 part of fermentation of bacillus extract, Chondrus crispus carry
Take 0.5 part of object, 0.1 part of carbohydrate isomer, 45 parts of water, 8 parts of oil, 2 parts of emulsifier, 3 parts of organic solvent, moisturizer 14
Part, 0.3 part of thickener, 1.5 parts of assistant for emulsifying agent.Wherein, oil includes 4 parts of neopentyl glycol two (thylhexoic acid) ester, the hydrogenation poly- last of the ten Heavenly stems
0.8 part of 3.2 parts of alkene and lecithin；Emulsifier is cetostearyl alcohol ethylhexoate；Organic solvent is ethyl alcohol；Moisturizer includes fourth
5 parts of 2 parts of glycol, 20 2 parts of methyl gluceth, 5 parts of glycerine and 1,3- propylene glycol；Thickener includes 0.05 part of xanthans, third
0.03 part of olefin(e) acid (ester) analog copolymer sodium, acrylic acid (ester) class/0.22 part of C10-30 alkylol acrylamide acid esters cross-linked polymer；Anti-corrosion
Agent is Phenoxyethanol；Freshener is menthol；It is Natrulon H-10 stearate to help emulsion.
The present embodiment provides a kind of preparation methods of lotion, and using the ingredient in above-mentioned formula as raw material, dosage is also abided by
Follow above-mentioned formula.Specifically include following steps：
Water, moisturizer, thickener and organic solvent are mixed to get the first mixture under 80 DEG C of temperature condition；It will be oily
Point, after emulsifier and assistant for emulsifying agent mix under 80 DEG C of temperature condition, then with the first mixture mixing 5min obtain the
Two mixtures；After second mixture is cooled to 45 DEG C, then with remaining ingredient it is mixed to get third mixture, it is quiet after filtering and discharging
Set 14h.
Embodiment 2
The present embodiment provides a kind of lotion with the very thin effect of four limbs, raw material includes 1.3 parts of caffeine, hazelnut oil
0.8 part, 1.0 parts of sunflower seed oil, 2.5 parts of butcher's broom root extract, 0.8 part of hydroiodic acid TEA salt, 1.3 parts of carnitine, horse chestnut soap
1.3 parts of glycosides, foreign 2.5 parts of ivy extract, 0.8 part of tripeptides -1,1.5 parts of fermentation of bacillus extract, Chondrus crispus carry
Take 1.5 parts of object, 0.3 part of carbohydrate isomer, 55 parts of water, 15 parts of oil, 4 parts of emulsifier, 5 parts of organic solvent, moisturizer 20
Part, 0.8 part of thickener, 0.6 part of preservative, 0.06 part of freshener, 0.2 part of essence, 2.5 parts of assistant for emulsifying agent.Wherein, oil includes
1 part of 7 parts of neopentyl glycol two (thylhexoic acid) ester, 7 parts of Nexbase 2004 and lecithin；Emulsifier is cetostearyl alcohol thylhexoic acid
Ester；Organic solvent is ethyl alcohol；Moisturizer includes 3 parts of butanediol, 20 3 parts of methyl gluceth, 7 parts of glycerine and 1,3- the third two
7 parts of alcohol；Thickener includes 0.1 part of xanthans, 0.1 part of acrylic acid (ester) analog copolymer sodium, acrylic acid (ester) class/C10-30 alkanols
0.6 part of acrylate crosspolymers；Preservative is Phenoxyethanol；Freshener is menthol；It is that Natrulon H-10 is stearic to help emulsion
Acid esters.
The present embodiment provides a kind of preparation methods of lotion, and using the ingredient in above-mentioned formula as raw material, dosage is also abided by
Follow above-mentioned formula.Specifically include following steps：
Water, moisturizer, thickener and organic solvent are mixed to get the first mixture under 85 DEG C of temperature condition；It will be oily
Point, after emulsifier and assistant for emulsifying agent mix under 85 DEG C of temperature condition, then with the first mixture mixing 10min obtain the
Two mixtures；After second mixture is cooled to 50 DEG C, then with remaining ingredient it is mixed to get third mixture, it is quiet after filtering and discharging
Set 14h.
Embodiment 3
The present embodiment provides a kind of lotion with the very thin effect of four limbs, raw material includes 0.9 part of caffeine, hazelnut oil
0.4 part, 0.7 part of sunflower seed oil, 1.8 parts of butcher's broom root extract, 0.4 part of hydroiodic acid TEA salt, 0.9 part of carnitine, horse chestnut soap
0.9 part of glycosides, foreign 1.8 parts of hederae folium/stem extraction, 0.4 part of tripeptides -1,0.8 part of fermentation of bacillus product extract, wrinkle
0.8 part of wave chondrus extract, 0.1 part of carbohydrate isomer, 48 parts of water, 9 parts of oil, 2 parts of emulsifier, organic solvent 3.5
Part, 16 parts of moisturizer, 0.47 part of thickener, 0.4 part of preservative, 0.05 part of freshener, 0.15 part of essence, 2 parts of assistant for emulsifying agent.Its
In, oil includes 1 part of 4 parts of neopentyl glycol two (thylhexoic acid) ester, 4 parts of Nexbase 2004 and lecithin；Emulsifier is that spermaceti is hard
Lipidol ethylhexoate；Organic solvent is ethyl alcohol；Moisturizer includes 2 parts of butanediol, 20 4 parts of methyl gluceth, glycerine 5
5 parts of part and 1,3- propylene glycol；Thickener includes 0.05 part of xanthans, 0.2 part of acrylic acid (ester) analog copolymer sodium, acrylic acid (ester)
Class/0.22 part of C10-30 alkylol acrylamide acid esters cross-linked polymer；Preservative is Phenoxyethanol；Freshener is menthol；Help emulsion
For Natrulon H-10 stearate.
The present embodiment provides a kind of preparation methods of lotion, and using the ingredient in above-mentioned formula as raw material, dosage is also abided by
Follow above-mentioned formula.Specific steps please refer to embodiment 3.
Embodiment 4
The present embodiment provides a kind of lotion with the very thin effect of four limbs, raw material includes 1.2 parts of caffeine, hazelnut oil
0.7 part, 0.9 part of sunflower seed oil, 2.2 parts of butcher's broom root extract, 0.6 part of hydroiodic acid TEA salt, 1.2 parts of carnitine, horse chestnut soap
1.2 parts of glycosides, foreign 2.2 parts of hederae folium/stem extraction, 0.6 part of tripeptides -1,1.2 parts of fermented soybean product extract, ripple angle
Pitch 1.2 parts of dish extract, 0.3 part of carbohydrate isomer, 52 parts of water, 13 parts of oil, 3 parts of emulsifier, 4.5 parts of organic solvent,
16 parts of moisturizer, 0.47 part of thickener, 0.4 part of preservative, 0.05 part of freshener, 0.15 part of essence, 2 parts of assistant for emulsifying agent.Wherein,
Oil includes 1 part of 6 parts of neopentyl glycol two (thylhexoic acid) ester, 6 parts of Nexbase 2004 and lecithin；Emulsifier is cetostearyl alcohol
Ethylhexoate；Organic solvent is ethyl alcohol；Moisturizer include 2 parts of butanediol, 20 4 parts of methyl gluceth, 5 parts of glycerine and
5 parts of 1,3- propylene glycol；Thickener include 0.05 part of xanthans, 0.2 part of acrylic acid (ester) analog copolymer sodium, acrylic acid (ester) class/
0.22 part of C10-30 alkylol acrylamide acid esters cross-linked polymer；Preservative is Phenoxyethanol；Freshener is menthol；It is poly- to help emulsion
- 10 stearate of glycerine.
The present embodiment provides a kind of preparation methods of lotion, and using the ingredient in above-mentioned formula as raw material, dosage is also abided by
Follow above-mentioned formula.Specific steps please refer to embodiment 3.
Embodiment 5
The present embodiment provides a kind of lotion with the very thin effect of four limbs, raw material includes 1 part of caffeine, hazelnut oil 0.5
Part, 0.8 part of sunflower seed oil, 2 parts of butcher's broom root extract, 0.5 part of hydroiodic acid TEA salt, 1 part of carnitine, 1 part of Ba 2672,
2 parts of foreign hederae folium/stem extraction, 0.5 part of tripeptides -1,1 part of fermented soybean product extract, Chondrus crispus extract 1
Part, increases 0.2 part of carbohydrate isomer, 52 parts of water, 11 parts of oil, 2.5 parts of emulsifier, 4 parts of organic solvent, 16 parts of moisturizer
Thick dose 0.47 part, 0.4 part of preservative, 0.05 part of freshener, 0.15 part of essence, 2 parts of assistant for emulsifying agent.Wherein, oil includes new penta
1 part of 5 parts of glycol two (thylhexoic acid) ester, 5 parts of Nexbase 2004 and lecithin；Emulsifier is cetostearyl alcohol ethylhexoate；
Organic solvent is ethyl alcohol；Moisturizer includes 2 parts of butanediol, 20 4 parts of methyl gluceth, 5 parts of glycerine and 1,3- propylene glycol 5
Part；Thickener includes 0.05 part of xanthans, 0.2 part of acrylic acid (ester) analog copolymer sodium, acrylic acid (ester) class/C10-30 alkanols third
0.22 part of olefin(e) acid ester cross-linked polymer；Preservative is Phenoxyethanol；Freshener is menthol；It is that Natrulon H-10 is stearic to help emulsion
Acid esters.
The present embodiment provides a kind of preparation methods of lotion, and using the ingredient in above-mentioned formula as raw material, dosage is also abided by
Follow above-mentioned formula.Specific steps please refer to embodiment 3.
Test example 1
The lotion being prepared in embodiment 5 is subjected to performance detection, the effect (present invention that record lotion loses weight to four limbs
Effect in other embodiment is similar, herein the explanation without specific data).
Detection method：The female volunteers (35-50 Sui) of 60 frequent sittings are divided into 3 groups:(1) in the finger of personal coach
Lower carry out Standard exercise is led, biweekly, while smearing comfort agent emulsion twice daily.(2) every at abdomen, arm and thigh
It smears lotion twice, without movement.(3) exercise identical with first group of carry out, while lotion twice is smeared daily.
In order to assess the improvement (i.e. front and back size reduction value) of the bodily form, to before using, 28 days and 56 after using after using
It is tested respectively, is analyzed the data of abdomen, thigh and arm, be the results are shown in Table 1-3.Arm geometry and thigh profile in table
Refer to common Zhou Jing, is detected using slide calliper rule.
You need to add is that above-mentioned comfort liquid is general lotion purchased in market, without containing the work provided in the embodiment of the present invention
Property ingredient.
The influence of lotion prepared by 1 embodiment of the present invention of table to abdomen
The influence of lotion prepared by 2 embodiment of the present invention of table to thigh
| Group | 28 days, thigh profile | 56 days, thigh profile |
| First group | 0 | -1.0cm |
| Second group | -0.4cm | -0.9cm |
| Third group | -0.5cm | -1.2cm |
The influence of lotion prepared by 3 embodiment of the present invention of table to arm
| Group | 28 days, arm geometry | 56 days, arm geometry |
| First group | -0.7cm | -0.9cm |
| Second group | -0.4cm | -0.6cm |
| Third group | -0.7cm | -1.0cm |
By table 1-3 it is found that using formula provided in an embodiment of the present invention and the obtained lotion of preparation method for four limbs and
The lipolysis of abdomen plays an important roll, and the lotion being prepared using the embodiment of the present invention is more compared to lotion effect purchased in market
It is good.
Test example 2
Fig. 1 is that macroscopic fold of arm reflects picture in test example 1, as can be known from Fig. 1, can be significantly reduced using lotion
The rugosity of arm.
Test example 3
Respectively test using before lotion, using lotion 15 days and using the smooth degree of 30 days skin of lotion, as a result see figure
2.Test method is：The digital pictures at lotion position are used using subject, then use skin surface pattern and depth analysis figure
The percentage of smoothness is obtained after spectrum software analysis.
As shown in Figure 2, the lotion prepared using the formula of the embodiment of the present invention and method is for improving skin smoothness tool
There is remarkable effect.2 lotions are used daily, after 30 days, skin smooth 6.8%；4 lotions are used daily, use 30
After it, skin smooth 11.1%.
In conclusion a kind of lotion with the very thin effect of four limbs provided by the invention, passes through the activearm in formula
The selection divided, specifically includes caffeine, hazelnut oil, sunflower seed oil, butcher's broom root extract, hydroiodic acid TEA salt, carnitine, seven
Leaf tree saponin(e, foreign hederae folium/stem extraction, tripeptides 1, bacillus or fermented soybean product extract, Chondrus crispus carry
Take object and carbohydrate isomer.The active matter added in lotion is a kind of proliposome, is made using the synergistic effect of each component
Three peptide materials formed squeeze out obtained compound by multiple, once being added in lotion, this proliposome ingredient ensures
The formation of liposome.The formula provided in the embodiment of the present invention can play the role of significantly decomposing limb fat, be suitble to
In popularization and application.
A kind of preparation method of lotion provided by the invention, method is simple, and obtained lotion can decompose
It is used widely in fat.
Embodiments described above is a part of the embodiment of the present invention, instead of all the embodiments.The reality of the present invention
The detailed description for applying example is not intended to limit the range of claimed invention, but is merely representative of the selected implementation of the present invention
Example.Based on the embodiments of the present invention, those of ordinary skill in the art are obtained without creative efforts
Every other embodiment, shall fall within the protection scope of the present invention.
Claims (10)
1. a kind of lotion with the very thin effect of four limbs, which is characterized in that its raw material includes active component, water, oil, emulsification
Agent, organic solvent and function additive；
Wherein, the active component include caffeine, hazelnut oil, sunflower seed oil, butcher's broom root extract, hydroiodic acid TEA salt,
Carnitine, Ba 2672, foreign hederae folium/stem extraction, tripeptides 1, bacillus or fermented soybean product extract, ripple angle
Pitch dish extract and carbohydrate isomer.
2. the lotion according to claim 1 with the very thin effect of four limbs, which is characterized in that it counts in parts by weight, it is described
The raw material of lotion includes that 0.8-1.3 parts of caffeine, 0.3-0.8 parts of hazelnut oil, 0.6-1.0 parts of sunflower seed oil, phyllodium tree root carry
Take 1.5-2.5 parts of object, 0.3-0.8 parts of hydroiodic acid TEA salt, 0.8-1.3 parts of carnitine, 0.8-1.3 parts of Ba 2672, foreign ivy
0.5-1.5 parts of leaf/1.5-2.5 parts of stem extraction, -1 0.3-0.8 parts of tripeptides, bacillus or fermented soybean product extract,
0.5-1.5 parts of Chondrus crispus extract, 0.1-0.3 parts of carbohydrate isomer, 45-55 parts of water, 8-15 parts of oil, emulsifier
14-25 parts of 2-4 parts, 3-5 parts of organic solvent and function additive；
Preferably, the raw material of the lotion includes 0.9-1.2 parts of caffeine, 0.4-0.7 parts of hazelnut oil, sunflower seed oil 0.7-
0.9 part, 1.8-2.2 parts of butcher's broom root extract, 0.4-0.6 parts of hydroiodic acid TEA salt, 0.9-1.2 parts of carnitine, Ba 2672
0.9-1.2 parts, foreign hederae folium/1.8-2.2 parts of stem extraction, -1 0.4-0.6 parts of tripeptides, bacillus or fermented soybean production
0.8-1.2 parts of object extract, 0.8-1.2 parts of Chondrus crispus extract, 0.1-0.3 parts of carbohydrate isomer, water 48-52
Part, 9-13 parts of oil, 2-3 parts of emulsifier, 3.5-4.5 parts of organic solvent and 17-22 parts of function additive.
3. the lotion according to claim 1 with the very thin effect of four limbs, which is characterized in that the function additive includes protecting
14-20 parts of humectant, 0.3-0.8 parts of thickener, 0.3-0.6 parts of preservative, 0.03-0.06 parts of freshener, 0.1-0.2 parts of essence,
1.5-2.5 parts of assistant for emulsifying agent；
Any one or a few in butanediol, methyl gluceth 20, glycerine and 1,3- propylene glycol of the moisturizer；
The thickener is selected from xanthans, acrylic acid (ester) analog copolymer sodium and acrylic acid (ester) class/C10-30 alkylol acrylamide acid
Any one or a few in ester cross-linked polymer；
The assistant for emulsifying agent is Natrulon H-10 stearate.
4. the lotion according to claim 3 with the very thin effect of four limbs, which is characterized in that the emulsifier is that spermaceti is hard
Lipidol ethylhexoate and/or polyglycereol-3-methyl distearate.
5. the lotion according to claim 1 with the very thin effect of four limbs, which is characterized in that the organic solvent is selected from alcohol
Class, esters or ethers, preferably alcohols, more preferably ethyl alcohol.
6. the lotion according to claim 1 with the very thin effect of four limbs, which is characterized in that the oil is selected from new penta 2
It is one or more in alcohol two (thylhexoic acid) ester, Nexbase 2004 and lecithin；
Preferably, the oil includes 4-6 parts of (thylhexoic acid) ester of neopentyl glycol two, 4-6 parts of Nexbase 2004 and lecithin
0.8-1.2 parts.
7. according to the preparation method of any one of the claim 3-6 lotions, which is characterized in that include the following steps：
The first mixture is obtained after the water, the moisturizer, the thickener and the organic solvent are mixed；
First mixture and the oil, the emulsifier and the assistant for emulsifying agent are mixed to get the second mixture；
Second mixture and the active component, the preservative, the freshener and the essence are mixed to get the
Three mixtures；
Preferably, the mixing temperature in the preparation process of first mixture is 80-85 DEG C.
8. the preparation method of lotion according to claim 7, which is characterized in that in the preparation process of second mixture
Including：
After the oil, the emulsifier and the assistant for emulsifying agent are mixed under 80-85 DEG C of temperature condition, then with described
One mixture mixing 5-10min.
9. the preparation method of lotion according to claim 7, which is characterized in that in the preparation process of the third mixture
Include：
After second mixture is cooled to 45-50 DEG C, then with the active component, the preservative, the freshener and
The essence mixes, and 10-14h is stood after filtering and discharging.
10. the lotion being prepared according to the preparation method of any one of the claim 7-9 lotions is in reducing fat
Using.
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| CN110251454A (en) * | 2019-07-30 | 2019-09-20 | 广州澳希亚实业有限公司 | It is a kind of improve black-eyed composition, using and a kind of Essence |
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| CN111012682A (en) * | 2019-12-23 | 2020-04-17 | 苏州绿叶日用品有限公司 | Slimming nano liposome and preparation method and application thereof |
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