JP2020015665A - External preparation for skin - Google Patents

Abstract

To provide an external preparation for skin which is synergistically improved in moisturizing effect by using glyceryl glucoside and a specific plant in combination.SOLUTION: There is provided an external preparation for skin which comprises the following (A) and (B): (A) glyceryl glucoside and (B) one or two or more kinds selected from a Sasa albo-marginata extract, a Murraya koenigii extract, and a cordyceps extract.SELECTED DRAWING: Figure 1

Description

  The present invention relates to an external preparation for skin comprising a combination of glyceryl glucoside and a specific plant extract.

Glyceryl glucoside is known to have a high moisturizing effect. (Patent Document 1)
It is known that an external preparation for skin containing Kumazasa extract has a moisturizing effect and is excellent in promoting the synthesis of ceramide which is an intercellular lipid. (Patent Document 2)
It is known that an external preparation for skin containing an extract obtained by extracting Cordyceps with a supercritical fluid or a subcritical fluid has an excellent moisturizing effect. (Patent Document 3)
It is known that skin cosmetics containing Murayakoenji extract have excellent ultraviolet absorbing effect and moisture retention. (Patent Document 4)

JP-A-11-222496 JP-A-11-199467 JP-A-2003-292430 JP-A-7-118132

  An object of the present invention is to provide an external preparation for skin that has a synergistic moisturizing effect by using glyceryl glucoside in combination with a specific plant.

The present invention
Provided is one or more selected from the group consisting of (A) glyceryl glucoside (B) Kumazasa extract, Murayakoenji extract, and Cordyceps sinensis extract containing the following (A) and (B).

  The skin external preparation of the present invention synergistically improves the moisturizing effect by using glyceryl glucoside in combination with a specific plant.

FIG. 1 is a diagram showing that the combined use of glyceryl glucoside and Kumazasa extract synergistically improves the water content of the stratum corneum. FIG. 2 is a diagram showing that the water content of the stratum corneum is synergistically improved by the combined use of glyceryl glucoside and Murayakoenji extract. FIG. 3 is a diagram showing that the combined use of glyceryl glucoside and a cordyceps extract enhances the water content of the stratum corneum synergistically.

  Hereinafter, embodiments for carrying out the present invention will be described.

  The external preparation for skin of the present invention can be used for any of cosmetics, quasi-drugs, pharmaceuticals and the like.

  As long as glyceryl glucoside can be blended into cosmetics, the production method is not limited to synthesis, fermentation method, etc. depending on the microorganism. Specifically, any of α-form, β-form and a mixture thereof can be used.

  The Kumazasa extract used in the present invention is an extract of Sasa veitchii belonging to the genus Sasa of the Poaceae family. As the extraction site, one or more selected from leaves, stems, whole plants, and above-ground sites are used. It is preferred to use leaves. As the Kumazasa extract, commercially available Falco Rex Kumazasa E (manufacturer: Ichimaru Falcos), Kumazasa extract (manufacturer: Maruzen Pharmaceutical), Kumazasa extract (manufacturer: Koei Kogyo Co., Ltd.) and the like can also be used.

  The extract of Murayakoenji used in the present invention is an extract of Murakaya koenigii (Chalcas koenigii) belonging to the genus Rutaceae. A leaf and a branch tip or a leaf is used as an extraction site. It is preferred to use leaves. A commercially available Murayaco Enzyme extract (manufacturer: Mikimoto Pharmaceutical Co., Ltd.) can also be used as the Murayaco Enzyme extract.

  There are no particular restrictions on the cordyceps used in the present invention, and the parasites of commonly known butterfly moths, Lepidoptera and Coleoptera, or parasites of the larvae of the insects or larvae, form sclerotium inside the body, and the host insects or their insects in summer. Any fruiting body formed on the body surface of the larva may be used. Cordyceps which can be particularly preferably used in the present invention include parasites of bat moths (Hepialus armoricanus Ober), which form sclerotium in their bodies and form root-rod-like fruiting bodies from their heads in summer. Cordyceps sinensis. Also, as cordyceps sinensis other than Cordycepsinensis and having a medicinal effect as a crude drug, there are known semi-bamboo (Cordyceps sobolifera B), pupa (Cordyceps militaris Link), mimikitake mushroom (Cordyceps nutans Pat) and the like, and these are also used in the present invention. It can be preferably used. By the method according to the present invention, any of these cordyceps can be extracted as long as they produce an active ingredient. Further, by using the method according to the present invention, extraction can be performed without distinction between fruiting bodies and angiosperms. However, in order to obtain particularly high yield, extraction from the fruiting bodies of Cordycepsinensis is preferred.

  A method for extracting a plant extract used in the present invention will be described.

  In the present invention, each of the above plants may be subjected to extraction as it is, but in consideration of extraction efficiency, it is preferable to perform extraction after performing processing such as shredding, drying, and pulverization. The extraction is performed by immersion in an extraction solvent. Stirring may be performed to increase the extraction efficiency, or homogenization may be performed in an extraction solvent. It is appropriate to set the extraction temperature to a temperature of about 5 ° C. to a temperature not higher than the boiling point of the extraction solvent. The extraction time varies depending on the type of the extraction solvent and the extraction temperature, but is suitably about 4 hours to 14 days.

  Examples of the extraction solvent include water, lower alcohols such as methanol, ethanol, propanol, and isopropanol; polyhydric alcohols such as 1,3-butylene glycol, propylene glycol, dipropylene glycol, and glycerin; and ethers such as ethyl ether and propyl ether. And polar organic solvents such as esters such as ethyl acetate and butyl acetate, and ketones such as acetone and ethyl methyl ketone. One or more of these can be selected and used. Further, physiological saline, phosphate buffer, phosphate buffered saline, and the like may be used.

  The extract of the above-mentioned plant with the above-mentioned solvent can be contained in the composition according to the present invention as it is, but the concentrated and dried one is redissolved in water or a polar solvent, or their skin physiological function is improved. It may be used after performing purification treatment such as decolorization, deodorization, and desalting within a range that does not impair the action, or performing fractionation treatment by column chromatography. For preservation, it can be freeze-dried after the purification treatment and dissolved in a solvent before use. It can also be used by being encapsulated in vesicles such as liposomes or microcapsules.

  In particular, when used as an external preparation for skin, the extract is contained in vesicles such as liposomes, microcapsules, or the like, whereby percutaneous absorption is enhanced and a higher anti-aging effect is exhibited.

  As a method for extracting cordyceps, it is preferable to use a hot water extract from the viewpoint of the effect of the present invention.

  The compounding amount of the above-mentioned plant in the present invention in the composition is preferably 0.00001 to 5% by weight, particularly 0.0001 to 1% by weight. Within this range, when a specific plant is combined and blended, a higher effect can be exhibited without affecting the temporal stability of the preparation and the plants in the preparation.

  In addition to the above-mentioned essential components, the skin external preparation of the present invention usually contains an aqueous component, an oily component, a humectant, a pigment, a surfactant, an ultraviolet absorber, and a thickener, which are usually added to the skin external preparation as needed. Agents, beauty ingredients, fragrances, high molecular substances, antibacterial and antimicrobial agents, alcohols, powders, scrubbing agents, biological components and the like can be appropriately compounded.

  The external preparation for skin of the present invention can be used, for example, in the form of lotions, emulsions, and ointments. Further, the method for producing the external preparation for skin of the present invention does not matter.

  Hereinafter, the present invention will be described specifically with reference to Examples, but the scope of the present invention is not limited thereto. In addition, the compounding quantity is a mass% unless there is particular notice.

  First, preparation examples of extracts of each plant used will be described.

[Kumazasa extract]
Kumazasa extract manufactured by Koei Kogyo Co., Ltd. was used as Kumazasa extract.

[Murayakoenji extract]
Murayakoenji extract was used as the Murayakoenji extract.

[Cordyceps extract]
The fruit body of Cordyceps sinensis, a Tibetan cordyceps, is dried, pulverized, and extracted with 10 times by mass of hot water for 2 hours. The liquid after filtration was dried under reduced pressure, dissolved in purified water so that the extract content became 1% by mass, aged for 48 hours, and filtered again to obtain a cordyceps extract.

[Glyceryl glucoside]
As glyceryl glucoside, α-GG manufactured by Tatsuma Honke Shuzo was used.

[Moisture retention test method]
-The subject performed the test under the guidance of not using cosmetics on the forearm for one week before the test.
・ First, the forearm was washed with a lathering agent.
-The forearm was wiped off and kept at rest for 15 minutes in an environment of 21 ± 0.5 ° C. and 50 ± 5% relative humidity.
-An area of 3 cm x 3 cm was recorded on each of the left and right forearms at three locations, and the water content of the stratum corneum before application was measured. -The samples described in Table 1 or Table 2 were applied, and the water content of the stratum corneum 60 minutes after application was measured.
9 μL of the sample was dropped on a 3 cm × 3 cm area using a pipette, and the sample was uniformly applied with a finger in a finger-sack.
-SKICON-200EX was used for the measurement of the water content of the stratum corneum.
・ The water content of the stratum corneum is easily affected by temperature, humidity, etc. on the day of measurement. did.

  As shown in Table 1, the effect of increasing the water content of the stratum corneum by applying Sample 3 was smaller than that of applying Sample 1 and Sample 2 alone (the amount of each active ingredient was doubled). It was improving synergistically.

  As shown in Table 2, the effect of increasing the water content of the stratum corneum was obtained by applying Sample 5 as compared with the case where Samples 1 and 3 were applied alone (the amount of each active ingredient was doubled). It was improving synergistically.

  As shown in Table 3, the effect of increasing the water content of the stratum corneum was improved by applying Sample 7 as compared with the case where Samples 1 and 4 were applied alone (the amount of each active ingredient was doubled). It was improving synergistically.

Example 1 Cream (1) Squalane 10.0 (% by mass)
(2) Stearic acid 2.0
(3) Hydrogenated palm kernel oil 0.5
(4) Hydrogenated soybean phospholipid 0.1
(5) Cetanol 3.6
(6) Lipophilic glyceryl monostearate 2.0
(7) Glycerin 10.0
(8) Methyl paraoxybenzoate 0.1
(9) Arginine (20% by mass aqueous solution) 15.0
(10) Purified water Amount based on the total amount as 100 (11) Carboxyvinyl polymer (1% by mass aqueous solution) 15.0
(12) Glyceryl glucoside (manufactured by Toyo Seika) 0.5
(13) Kumazasa extract 0.5
Production method: The oil phase components (1) to (6) are dissolved by heating at 80 ° C. On the other hand, the aqueous phase components (7) to (10) are heated and dissolved at 80 ° C. The oil phase component is added thereto with stirring, and the mixture is uniformly emulsified by a homogenizer. After the emulsification is completed, (11) is added, cooling is started, and (12) and (13) are added at 40 ° C. and mixed uniformly.

Example 2 Emulsion (1) Squalane 10.0 (% by mass)
(2) Methylphenyl polysiloxane 4.0
(3) Hydrogenated palm kernel oil 0.5
(4) Hydrogenated soybean phospholipid 0.1
(5) Polyoxyethylene monostearate
Sorbitan (20EO) 1.3
(6) Sorbitan monostearate 1.0
(7) Glycerin 4.0
(8) Methyl paraoxybenzoate 0.1
(9) Carboxyvinyl polymer 0.15
(10) Purified water Amount with the total amount being 100 (11) Arginine (1% by mass aqueous solution) 20.0
(12) Glyceryl glucoside (manufactured by Toyo Seika) 0.5
(13) Kumazasa extract 0.3
Production method: The oil phase components (1) to (6) are dissolved by heating at 80 ° C. On the other hand, the aqueous phase components (7) to (10) are heated and dissolved at 80 ° C. The oil phase component is added thereto with stirring, and the mixture is uniformly emulsified by a homogenizer. After completion of the emulsification, cooling is started, and (11) to (13) are sequentially added and uniformly mixed.

[Example 3] Lotion (1) Ethanol 15.0 (% by mass)
(2) Polyoxyethylene (40EO) hydrogenated castor oil 0.3
(3) Fragrance 0.1
(4) Purified water Amount based on the total amount as 100 (5) Citric acid 0.02
(6) Sodium citrate 0.1
(7) Glycerin 1.0
(8) Hydroxyethyl cellulose 0.1
(9) Glyceryl glucoside (manufactured by Toyo Seika) 0.3
(10) Murayakoenji extract 0.3
Production method: (2) and (3) are dissolved in (1). After dissolution, (4) to (8) are sequentially added, and then the mixture is sufficiently stirred, and (9) and (10) are added and mixed uniformly.

[Example 4] Essence (1) Purified water Amount based on the total amount of 100 (2) Glycerin 10.0 (% by mass)
(3) Sucrose fatty acid ester 1.3
(4) Carboxyvinyl polymer (1% by mass aqueous solution) 17.5
(5) Sodium alginate (1% by mass aqueous solution) 15.0
(6) Polyglyceryl monolaurate 1.0
(7) Macadamia nut oil fatty acid phytosteryl 3.0
(8) N-lauroyl-L-glutamic acid di (phytosteryl-2-octyldodecyl) 2.0
(9) Hardened palm oil 2.0
(10) Squalane (derived from olives) 1.0
(11) Behenyl alcohol 0.75
(12) Beeswax 1.0
(13) Jojoba oil 1.0
(14) 1,3-butylene glycol 10.0
(15) L-arginine (10% by mass aqueous solution) 2.0
(16) Edelweiss extract 0.2
(17) Glyceryl glucoside (manufactured by Toyo Seika Co., Ltd.) 0.2
(18) Kumazasa extract 0.15
(19) Murayakoenji extract 0.15
(20) Cordyceps extract 0.15
Production method: The aqueous phase components (1) to (6) are mixed and heated and dissolved at 75 ° C. On the other hand, the oil phase components (7) to (14) are mixed and heated and dissolved at 75 ° C. Next, after the oil phase component is added to the water phase component to perform preliminary emulsification, the mixture is uniformly emulsified by a homomixer. After completion of the emulsification, cooling is started, and (15) is added at 50 ° C. Further cool to 40 ° C., add (16) to (20), and mix uniformly.

Example 5 Aqueous Gel (1) Carboxyvinyl Polymer 0.5 (% by mass)
(2) Purified water Amount with the total amount being 100 (3) Sodium hydroxide (10% by mass aqueous solution) 0.5
(4) Methyl paraoxybenzoate 0.1
(5) Glyceryl glucoside (manufactured by Toyo Seika) 0.3
(6) Murayakoenji extract 0.2
(7) Fragrance 0.1
(8) Polyoxyethylene (60EO) hydrogenated castor oil 0.1
Production method: (1) is added to (2), and after stirring uniformly, (3) is added. After uniformly stirring, (4) to (8) are added and uniformly stirred and mixed.

Example 6 Cleansing Charge (1) Squalane 81.0 (% by mass)
(2) Polyoxyethylene glyceryl isostearate 15.0
(3) Purified water Amount with the total amount being 100 (4) Glyceryl glucoside (manufactured by Toyo Seika) 0.2
(5) Cordyceps extract 0.5
Production method: (1) and (2) are uniformly dissolved. To this, (3) to (5) are sequentially added and mixed uniformly.

[Example 7] Facial cleansing foam (1) Stearic acid 16.0 (% by mass)
(2) myristic acid 16.0
(3) Lipophilic glyceryl monostearate 2.0
(4) Glycerin 20.0
(5) Sodium hydroxide 7.5
(6) Coconut oil fatty acid amidopropyl betaine 1.0
(7) Purified water Amount with the total amount being 100 (8) Glyceryl glucoside (manufactured by Toyo Seika Co., Ltd.) 0.4
(9) Kumazasa extract 0.4
Production method: The oil phase components (1) to (4) are heated and dissolved at 80 ° C. On the other hand, the aqueous phase components (5) to (7) are heated and dissolved at 80 ° C., and uniformly mixed and stirred with the oil phase components. Start cooling, add (8) and (9) at 40 ° C and mix uniformly.

Example 8 Makeup Base Cream (1) Squalane 10.0 (% by mass)
(2) Cetanol 2.0
(3) Glycerin tri-2-ethylhexanoate 2.5
(4) Lipophilic glyceryl monostearate 1.0
(5) Propylene glycol 11.0
(6) Sucrose fatty acid ester 1.3
(7) Purified water Amount with the total amount being 100 (8) Titanium oxide 1.0
(9) Bengala 0.1
(10) Yellow iron oxide 0.4
(11) Fragrance 0.1
(12) Glyceryl glucoside (manufactured by Toyo Seika) 0.2
(13) Murayakoenji extract 0.1
Production method: The oil phase components (1) to (4) are mixed and dissolved by heating at 75 ° C. On the other hand, the aqueous phase components (5) to (7) are mixed and dissolved by heating at 75 ° C., and the pigments (8) to (10) are added thereto and uniformly dispersed by a homomixer. The oil phase component is added to the water phase component and emulsified by a homomixer. After completion of the emulsification, cooling is started, and the components (11) to (13) are added at 40 ° C. and uniformly mixed.

Example 9 Emulsion Foundation (1) Methylpolysiloxane 2.0 (% by mass)
(2) Squalane 5.0
(3) Octyldodecyl myristate 5.0
(4) Cetanol 1.0
(5) Polyoxyethylene (20EO)
Sorbitan monostearate 1.3
(6) Sorbitan monostearate 0.7
(7) 1,3-butylene glycol 8.0
(8) Xanthan gum 0.1
(9) Methyl paraoxybenzoate 0.1
(10) Purified water Amount with the total amount being 100 (11) Titanium oxide 9.0
(12) Talc 7.4
(13) Bengala 0.5
(14) Yellow iron oxide 1.1
(15) Black iron oxide 0.1
(16) Fragrance 0.1
(17) Glyceryl glucoside (manufactured by Toyo Seika Co., Ltd.) 0.2
(18) Cordyceps extract 0.1
Production method: The oil phase components (1) to (6) are mixed and dissolved by heating at 75 ° C. On the other hand, the aqueous phase components (7) to (10) are mixed and dissolved by heating at 75 ° C., and the pigments (11) to (15) are added thereto and uniformly dispersed by a homomixer. Add oil phase components and emulsify. After the completion of the emulsification, cooling is started, and the components (16) to (18) are sequentially added at 40 ° C. and uniformly mixed.

[Example 10] Water-in-oil emollient cream (1) Liquid paraffin 30.0 (% by mass)
(2) Microcrystalline wax 2.0
(3) Vaseline 5.0
(4) Diglycerin oleate 5.0
(5) Sodium chloride 1.3
(6) Potassium chloride 0.1
(7) Propylene glycol 3.0
(8) 1,3-butylene glycol 5.0
(9) Methyl paraoxybenzoate 0.1
(10) Glyceryl glucoside (manufactured by Toyo Seika Co., Ltd.) 0.2
(11) Cordyceps extract 0.1
(12) Purified water Total amount to 100 (13) Fragrance 0.1
Production method: (5) and (6) are dissolved in a part of (12) to 50 ° C., and gradually added to (4) heated to 50 ° C. with stirring. After mixing, the mixture is heated and dissolved at 70 ° C. and uniformly dispersed in (1) to (3). A mixture obtained by heating and dissolving (7) to (11) in the remainder of (12) at 70 ° C. is added thereto with stirring, and emulsified by a homomixer. After emulsification is completed, cooling is started, (13) is added at 40 ° C., and the mixture is uniformly mixed.

[Example 11] Pack (1) Purified water Amount based on the total amount of 100 (2) Polyvinyl alcohol 12.0 (% by mass)
(3) Ethanol 17.0
(4) Glycerin 5.0
(5) polyethylene glycol (average molecular weight 1000) 2.0
(6) Glyceryl glucoside (manufactured by Toyo Seika) 0.2
(7) Kumazasa extract 0.2
(8) Fragrance 0.1
Production method: (2) and (3) are mixed, heated to 80 ° C, and dissolved in (1) heated to 80 ° C. After uniform dissolution, (4) and (5) are added, and cooling is started with stirring. Cool to 40 ° C., add (6) to (8), and mix uniformly.

Example 12 Bath agent (1) Fragrance 0.3 (% by mass)
(2) Glyceryl glucoside (manufactured by Toyo Seika Co., Ltd.) 0.2
(3) Murayakoenji extract 0.2
(4) Sodium bicarbonate 50.0
(5) Sodium sulfate 49.3
Production method: (1) to (5) are mixed uniformly.

Example 13 Sheet Pack (1) Fragrance 0.1 (% by mass)
(2) 1,3-butylene glycol 5.0
(3) Glycerin 5.0
(4) Ethanol 3.0
(5) Glyceryl glucoside (manufactured by Toyo Seika) 0.2
(6) Cordyceps extract 0.2
(7) Purified water A quantity production method in which the total amount is 100: After uniformly mixing (1) to (7), a nonwoven sheet is impregnated.

Claims (1)

An external preparation for skin containing the following (A) and (B).
(A) glyceryl glucoside (B) one or more selected from Kumazasa extract, Murayakoenji extract, Cordyceps sinensis extract

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