JP5795146B2 - Moisturizer and external preparation for skin - Google Patents

Description

  The present invention relates to a moisturizing agent and a skin external preparation containing an Alaceaceae Chrysalidocarpus plant or an extract thereof.

  Conventionally, in order to provide a moisturizing ingredient that prevents the skin from drying and moisturizes the skin, various active ingredients have been studied. In particular, naturally-derived components are known to have various pharmacological and cosmetic effects, and so far, applications of extracts such as plants and fungi to skin external preparations have been studied.

  For example, as a moisturizing effect excellent in skin moisturizing effect and safety, cell water (see Patent Document 1), which is a distilled fraction obtained by distilling citrus husks under reduced pressure, and a saltbush extract of red crustaceae (patent document 1) Document 2) has been known so far.

JP 2009-196898 A JP 2006-248932 A

  Thus, various naturally derived components have been applied so far for the purpose of moisturizing the skin. However, there are many naturally-derived components whose effects are not yet known, and the development of an effective component having an excellent moisturizing action has been expected.

  As a result of studying various components derived from nature, the present inventors have found that there is an excellent moisturizing action in a plant belonging to the genus Chrysaliscarpus sp. The present invention was completed through repeated headings and further studies.

  That is, the present invention relates to a moisturizing agent and a skin external preparation containing at least one plant selected from a plant belonging to the genus Chrysalis chrysalis carpus or an extract thereof.

  According to the present invention, it is possible to provide a moisturizing agent and a skin external preparation having an excellent effect by blending one or more plants selected from plants belonging to the genus Chrysaliscarpus genus or an extract thereof. it can.

It is a figure showing the change of the stratum corneum moisture content by time passage after extract application.

  The Chrysalidocarpus genus plant used in the present invention is a woody monocotyledonous plant belonging to the palm family. About 20 species grow naturally in tropical rainforest climate areas such as Madagascar and Africa. In particular, Areca palm (Chrysalidocarpus lutescens) is well known for ornamental use.

  The present invention is not particularly limited as long as it is a Chrysalis carpus genus plant, but from the viewpoint of the effect of the present invention, areca palm is suitable.

  When using these Chrysalis carpus genus plants, there are no particular restrictions on the use site, and any site such as leaves, roots, stems, stems, flowers, etc. can be used, and multiple sites are used in combination However, it is preferable to use fruit.

  In the extraction, the plant may be used as it is, but considering the extraction efficiency, it is preferable to perform the extraction after performing processing such as shredding, drying, and pulverization.

  The extraction can be performed by immersing in an arbitrary extraction solvent for a predetermined time. The extraction solvent may be heated as necessary. Alternatively, extraction can be performed using a supercritical fluid or a subcritical fluid. In order to increase the extraction efficiency, the mixture may be stirred or homogenized in an extraction solvent. The extraction temperature is suitably about 5 ° C. to the boiling point of the extraction solvent. The extraction time varies depending on the type of extraction solvent and the extraction temperature, but is suitably about 1 hour to 14 days.

  As an extraction solvent, in addition to water, lower alcohols such as methanol, ethanol, propanol and isopropanol; polyhydric alcohols such as 1,3-butylene glycol, propylene glycol, dipropylene glycol and glycerin; ethers such as ethyl ether and propyl ether Solvents such as esters; esters such as butyl acetate and ethyl acetate; ketones such as acetone and ethyl methyl ketone can be used. These may be used alone or in combination of any two or more. Saline, phosphate buffer, phosphate buffered saline, and the like may be used. Furthermore, you may use 1 type, or 2 or more types of supercritical liquids and subcritical liquids, such as water, a carbon dioxide, ethylene, propylene, ethanol, methanol, ammonia.

  The above-mentioned extract of Chrysaliscarpus genus plant using the above solvent can be used as it is, but it may be left to stand for a certain period of time and matured, or the concentrated and dried product may be used as water or a polar solvent. It can be dissolved again and used. Alternatively, it may be used after performing purification treatment such as decolorization, deodorization, and desalting, and fractionation treatment by column chromatography or the like within a range not impairing these physiological functions. The said extract of Chrysalidocarpus genus plant, its processed material, and a fraction can also be used after freeze-drying after each process and fractionation, and melt | dissolving in a solvent at the time of use. It can also be used by encapsulating in vesicles such as liposomes or microcapsules.

  The Chrysalis carpus genus plant or its extract has an excellent moisturizing action and can be used as a moisturizing agent and a skin external preparation.

  A moisturizing agent containing a chrysalidocarpus genus plant or an extract thereof as an active ingredient has an excellent effect of increasing the amount of water in the stratum corneum and exhibits an excellent moisturizing effect.

  A skin external preparation containing a Chrysalidocarpus genus plant or an extract thereof exhibits an excellent moisturizing action.

  Each of these agents is not limited at all in terms of its form and the presence or absence of blending of other components, etc., as long as it contains a chrysaliscarpus genus plant or an extract thereof as an active ingredient. As for the form, any form such as liquid, paste, gel, solid, powder, etc. can be selected according to its use and the like, vehicle (excipient), solvent, Other general additives (antioxidants, colorants, dispersants, etc.) can optionally be included.

  Here, the external preparation for skin means all external compositions for external use on the skin or hair, such as cosmetics, quasi-drugs, and external medicines.

  The dosage form of the external preparation for skin is arbitrary, and can be provided, for example, as a solubilizing system such as lotion, a dispersion system such as calamine lotion, or an emulsifying system such as cream or emulsion. Further, it can be provided in various dosage forms such as an aerosol form, an ointment, and a poultice filled with a propellant.

  Specifically, various cosmetics such as emulsions, creams, lotions, lotions, packs, cosmetic liquids, cleaning agents, makeup cosmetics, etc .; liquids, ointments, powders, granules, aerosols, patches, poultices, etc. Various forms of cosmetics, quasi drugs, topical medicines, and the like can be exemplified.

  In addition to Chrysalidocarpus genus plants or extracts thereof, external preparations for skin are usually blended in pharmaceuticals, quasi drugs, skin cosmetics, hair cosmetics and cleansing agents, etc., as needed and necessary. Optional ingredients such as water, oily ingredients, moisturizers, powders, pigments, emulsifiers, solubilizers, gelling agents, detergents, UV absorbers, anti-inflammatory agents, thickeners, pH adjusters, chelating agents Drugs (medicinal ingredients), fragrances, resins, fungicides, fungicides, antioxidants, alcohols, and the like can be appropriately blended. Furthermore, within the range not impairing the effects of the present invention, other moisturizers, anti-aging agents, whitening agents, antioxidants and slimming agents, plants other than Chrysalis carpus genus plants or extracts thereof are also possible. .

  The amount of the external preparation for skin of the Chrysalis carpus genus plant or its extract can be adjusted depending on the type, purpose, etc. From the viewpoint of effect and stability, the total amount is 0 in terms of solid content. 0.0001 to 10.0% by mass is preferable, 0.001 to 5.0% by mass is more preferable, 0.01 to 5% by mass is further preferable, and 0.1 to 5% by mass is more preferable. It is.

  In the following, preparation examples of Chrysalistocarpus genus plant extracts, test methods for evaluating the moisturizing effect, and formulation examples as external preparations for skin will be described in more detail, but the technical scope of the present invention is not limited thereby. It is not something.

[Extract 1: Ethanol extract]
Areca palm (fruit) was dried and pulverized, 50 vol% ethanol of 20 times the sample mass was added and extracted at room temperature with stirring for 3 hours, and then insolubles were removed by filtration. After concentration under reduced pressure, freeze-drying was performed to obtain an extract.

[Extract 2: Hot water extract]
Areca palm (fruit) was dried and pulverized, purified water of 20 times the mass of the sample was added, and the mixture was extracted by heating at 120 ° C. for 20 minutes in an autoclave. An insoluble material was removed by suction filtration while maintaining a high temperature, and then lyophilized to obtain an extract.

  The moisturizing effect of Areca palm (fruit) was evaluated using the above extract.

<Moisturizing effect (horn layer moisture content increasing action)>
Evaluation of the stratum corneum water content increasing action of Areca palm (fruit) extract was performed by the following method.

Prepare 1% by weight aqueous solution of Areca palm (fruit) extract 1 in distilled water, apply 2 μL in the range of forearm 3 × 4 cm ² , stratum corneum before application, 15, 30, 60, 90, 120 minutes before application The amount of water was measured. The keratin water content was measured at 5 points from each application site using SKICON-200 (manufactured by IBI S Co., Ltd.). Table 1 shows the relative values with the average value of the five-point measurement values as the keratin water content and the keratin water content before application as 1. As a control, the same amount of distilled water was applied, and the amount of stratum corneum was measured in the same manner.

  As is clear from Table 1 and FIG. 1, the aqueous solution to which Areca palm (fruit) extract is added exhibits an excellent moisturizing effect because a high stratum corneum moisture content increasing action is observed.

  Then, the prescription example of the skin external preparation which mix | blended the areca palm (fruit) extract obtained by said each preparation method is shown.

[Example 1] Emulsion (1) Squalane 10.0 (mass%)
(2) Methylphenylpolysiloxane 4.0
(3) Hydrogenated palm kernel oil 0.5
(4) Hydrogenated soybean phospholipid 0.1
(5) Polyoxyethylene monostearate
Sorbitan (20E.O.) 1.3
(6) Sorbitan monostearate 1.0
(7) Glycerin 4.0
(8) Methyl paraoxybenzoate 0.1
(9) Carboxyvinyl polymer 0.15
(10) Purified water 100 (11) Arginine (1% by weight aqueous solution) 20.0
(12) Extract 1 5.0
Production method: The oil phase components (1) to (6) are heated and dissolved at 80 ° C. On the other hand, the aqueous phase components (7) to (10) are dissolved by heating at 80 ° C. The oil phase component is added to this while stirring and uniformly emulsified with a homogenizer. After cooling, (11) and (12) are sequentially added at 40 ° C. and mixed uniformly.

[Example 2] Lotion (1) Ethanol 15.0 (mass%)
(2) Polyoxyethylene (40E.O.) hydrogenated castor oil 0.3
(3) Fragrance 0.1
(4) Purified water 100 (5) Citric acid 0.02
(6) Sodium citrate 0.1
(7) Glycerin 1.0
(8) Hydroxyethyl cellulose 0.1
(9) Extract 2 1.0
Production method: (2) and (3) are dissolved in (1). Further, after sequentially adding (4) to (8), the mixture is sufficiently stirred, and (9) is added and mixed uniformly.

[Example 3] Cream (1) Squalane 10.0 (mass%)
(2) Stearic acid 2.0
(3) Hydrogenated palm kernel oil 0.5
(4) Hydrogenated soybean phospholipid 0.1
(5) Cetanol 3.6
(6) Lipophilic glyceryl monostearate 2.0
(7) Glycerin 10.0
(8) Methyl paraoxybenzoate 0.1
(9) Arginine (20 mass% aqueous solution) 15.0
(10) Remainder 100 (11) Carboxyvinyl polymer (1% by weight aqueous solution) 15.0
(12) Extract 1 5.0
Production method: The oil phase components (1) to (6) are heated and dissolved at 80 ° C. On the other hand, the aqueous phase components (7) to (10) are dissolved by heating at 80 ° C. The oil phase component is added to this while stirring and uniformly emulsified with a homogenizer. (11) is added and stirred, then cooled and (12) is added at 40 ° C. and mixed uniformly.

[Example 4] Cosmetic liquid (1) The balance (mass%) of purified water 100
(2) Glycerin 10.0
(3) Sucrose fatty acid ester 1.3
(4) Carboxyvinyl polymer (1% by weight aqueous solution) 17.5
(5) Sodium alginate (1% by weight aqueous solution) 15.0
(6) Polyglyceryl monolaurate 1.0
(7) Macadamia nut oil fatty acid phytosteryl 3.0
(8) N-lauroyl-L-glutamic acid di (phytosteryl-2-octyldodecyl) 2.0
(9) Hardened palm oil 2.0
(10) Squalane (derived from olive) 1.0
(11) Behenyl alcohol 0.75
(12) Beeswax 1.0
(13) Jojoba oil 1.0
(14) 1,3-butylene glycol 10.0
(15) L-arginine (10% by mass aqueous solution) 2.0
(16) Extract 2 3.0
Production method: The aqueous phase components (1) to (6) are mixed and dissolved by heating at 75 ° C. On the other hand, the oil phase components (7) to (14) are mixed and dissolved by heating at 75 ° C. Next, the oil phase component is added to the aqueous phase component and preliminary emulsification is performed, followed by uniform emulsification with a homomixer. After cooling, add (15) at 50 ° C. and (16) at 40 ° C. and mix uniformly.

[Example 5] Aqueous gel (1) Carboxyvinyl polymer 0.5 (mass%)
(2) The balance made into purified water 100 (3) Sodium hydroxide (10 mass% aqueous solution) 0.5
(4) Ethanol 10.0
(5) Methyl paraoxybenzoate 0.1
(6) Fragrance 0.1
(7) Extract 2 0.5
(8) Polyoxyethylene (60E.O.) hydrogenated castor oil 1.0
Manufacturing method: (1) is added to (2), and after stirring uniformly, (3) is added. After stirring uniformly, (5) previously dissolved in (4) is added. After stirring uniformly, the previously mixed (6) to (8) are added and stirred and mixed uniformly.

[Example 6] Cleansing fee (1) Squalane 81.0 (mass%)
(2) Polyoxyethylene glyceryl isostearate 15.0
(3) Extract 1 4.0
Manufacturing method: (1) and (2) are uniformly dissolved. (3) is added to this, and it mixes uniformly.

[Example 7] Face-wash foam (1) Stearic acid 16.0 (mass%)
(2) Myristic acid 16.0
(3) Lipophilic glyceryl monostearate 2.0
(4) Glycerin 25.0
(5) Sodium hydroxide 7.5
(6) Palm oil fatty acid amidopropyl betaine 1.0
(7) The balance which is made into purified water 100 (8) Extract 2 0.1
Production method: The oil phase components (1) to (4) are heated and dissolved at 80 ° C. On the other hand, the water phase components (5) to (7) are heated and dissolved at 80 ° C., and the oil phase components are uniformly mixed and stirred. After cooling, add (8) at 40 ° C. and mix uniformly.

[Example 8] Make-up base cream (1) Squalane 10.2 (% by mass)
(2) Cetanol 2.0
(3) Glycerin tri-2-ethylhexanoate 2.5
(4) Lipophilic glyceryl monostearate 1.0
(5) Propylene glycol 11.0
(6) Sucrose fatty acid ester 1.3
(7) The balance which makes 100 purified water (8) Titanium oxide 1.0
(9) Bengala 0.1
(10) Yellow iron oxide 0.4
(11) Fragrance 0.1
(12) Extract 1 3.0
Production method: The oil phase components (1) to (4) are mixed and dissolved by heating at 75 ° C. On the other hand, the aqueous phase components (5) to (7) are mixed and dissolved by heating at 75 ° C., and the pigments (8) to (10) are added thereto and dispersed uniformly with a homomixer. The oil phase component is added to the water phase component and emulsified with a homomixer. After cooling, the components (11) and (12) are added at 40 ° C. and mixed uniformly.

[Example 9] Emulsion foundation (1) Methylpolysiloxane 2.0 (mass%)
(2) Squalane 5.0
(3) Octyldodecyl myristate 5.0
(4) Cetanol 1.0
(5) Polyoxyethylene (20E.O.)
Sorbitan monostearate 1.3
(6) Sorbitan monostearate 0.7
(7) 1,3-butylene glycol 8.0
(8) Xanthan gum 0.1
(9) Methyl paraoxybenzoate 0.1
(10) Remainder water 100 (11) Titanium oxide 9.0
(12) Talc 7.4
(13) Bengala 0.5
(14) Yellow iron oxide 1.1
(15) Black iron oxide 0.1
(16) Fragrance 0.1
(17) Extract 2 0.5
Production method: The oil phase components (1) to (6) are mixed and dissolved by heating at 75 ° C. On the other hand, the water phase components (7) to (10) are mixed, dissolved by heating at 75 ° C., the pigments (11) to (15) are added thereto, and the mixture is uniformly dispersed with a homomixer. Add oil phase ingredients and emulsify. After cooling, components (16) and (17) are sequentially added at 40 ° C. and mixed uniformly.

[Example 10] Water-in-oil emollient cream (1) Liquid paraffin 34.0 (mass%)
(2) Microcrystalline wax 2.0
(3) Vaseline 5.0
(4) Diglycerin oleate 5.0
(5) Sodium chloride 1.3
(6) Potassium chloride 0.1
(7) Propylene glycol 3.0
(8) 1,3-butylene glycol 5.0
(9) Methyl paraoxybenzoate 0.1
(10) Extract 1 3.0
(11) The balance of 100 purified water (12) Fragrance 0.1
Production method: Dissolve (5) and (6) in a part of (11) to 50 ° C, and gradually add to (4) heated to 50 ° C with stirring. After mixing this, it disperse | distributes uniformly to (1)-(3) heated and melt | dissolved at 70 degreeC. (7) to (10) are added to the remainder of (11) heated and dissolved at 70 ° C. with stirring, and emulsified with a homomixer. After cooling, add (12) at 40 ° C. and mix uniformly.

[Example 11] The balance (mass%) of pack (1) purified water 100
(2) Polyvinyl alcohol 12.0
(3) Ethanol 17.0
(4) Glycerin 9.0
(5) Polyethylene glycol (average molecular weight 1000) 2.0
(6) Extract 2 1.0
(7) Fragrance 0.1
Production method: (2) and (3) are mixed, heated to 80 ° C, and then dissolved in (1) heated to 80 ° C. After evenly dissolving, add (4) and (5) and cool with stirring. Add (6) and (7) at 40 ° C. and mix uniformly.

[Example 12] Bath agent (1) Fragrance 0.3 (mass%)
(2) Extract 1 3.0
(3) Sodium bicarbonate 50.0
(4) Sodium sulfate 46.7
Production method: (1) to (4) are mixed uniformly.

[Example 13] Hair wax (1) Stearic acid 3.0 (mass%)
(2) Microcrystalline wax 2.0
(3) Cetyl alcohol 3.0
(4) Highly polymerized methylpolysiloxane 2.0
(5) Methylpolysiloxane 5.0
(6) Poly (oxyethylene / oxypropylene)
Methylpolysiloxane copolymer 1.0
(7) Methyl paraoxybenzoate 0.1
(8) 1,3-butylene glycol 7.5
(9) Arginine 0.7
(10) Purified water 100 (11) Extract 2 2.0
(12) Fragrance 0.1
Production method: The oil phase components (1) to (6) are mixed and heated and dissolved at 75 ° C. On the other hand, the aqueous phase components (7) to (10) are dissolved by heating at 75 ° C., the oil phase component is added, and the mixture is emulsified with a homomixer. After cooling, the components (11) and (12) are added at 40 ° C. and mixed uniformly.

Example 14 Hair artic (1) Ethanol 50.0 (mass%)
(2) The balance of purified water 100 (3) Extract 1 3.0
(4) Fragrance 0.1
Production method: Components (1) to (4) are mixed and homogenized.
The remainder manufacturing method which makes it 100 mL: (1)-(9) is added to (10) sequentially, and is made uniform.

  The skin external preparations shown in Examples 1 to 14 were compositions having a moisturizing action.

Claims (1)

A humectant containing, as an active ingredient, an aqueous ethanol extract of a Chrysalidocarpus plant.

Images