JP2006176414A - External preparation for skin - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To obtain an external preparation for skin which has high moisture retaining effect on the skin, beautiful skin effect, ameliorating effect on chapped skin and excellent compatibility with the skin. <P>SOLUTION: The external preparation for skin comprises a combination of an extract of Prunus cerasus and an extract of a plant having a convergent effect, exhibits moisture retaining effect on the skin, beautiful skin effect and ameliorating effect on chapped skin and excellent compatibility with the skin. Preferably one or more kinds selected from an extract of Betula platyphylla, an extract of green tea are used as the extract of a plant having convergent effect. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

  The present invention uses a combination of a cherry cherry extract and a plant extract having an astringent effect, and thus can exhibit a high skin moisturizing effect, skin beautifying effect and skin roughening effect, and skin external use that is familiar with the skin. It relates to the agent.

  Conventionally, extracts of many kinds of plants including medicinal plants have been used for external preparations for skin (for example, Non-Patent Document 1, Non-Patent Document 2, etc.). In recent years, with the increase in plant orientation due to nature and animal welfare, there is an increasing tendency to seek active ingredients in plant and fungal extracts.

  However, although plant and fungal extracts each have a variety of actions, the action is generally not so strong, and the external preparation for skin contains an amount of plant or fungal extract that produces the expected action and effect. In some cases, unfavorable coloring and odor were observed, and the stability of the preparation was decreased. Although attempts have been made to enhance the action and effect by using multiple plant and fungal extracts in combination, various factors are involved in the physiological functions of the skin, so the skin condition must be sufficiently improved. It is difficult.

Fragrance Journal, FJ, 1979, first special issue Fragrance Journal, FJ, 1986, Special Issue 6

  An object of the present invention is to obtain a skin external preparation that can exhibit a high skin moisturizing effect, a beautiful skin effect, and a rough skin improvement effect, and that is well-familiar with the skin.

  As a result of various studies to solve the above-mentioned problems, it has been found that a good skin moisturizing effect, skin beautifying effect, and rough skin improving effect can be obtained by combining a cherry tree extract and a plant extract having an astringent effect. The present invention has been completed.

  That is, in the present invention, the cherry cherry extract and the plant extract having an astringent effect are combined and blended into the external preparation for skin.

  As the plant extract having an astringent effect, it is particularly preferable to use one or two kinds of plant extracts selected from birch extract and green tea extract.

  According to the present invention, a skin external preparation that can exhibit a high skin moisturizing effect, a beautiful skin effect, and a rough skin improving effect and that is well-familiar with the skin can be obtained.

  The cherry cherry extract used in the present invention and the plant extract having an astringent effect will be described.

In the present invention, an extract of the cherry cherry ( Cerasus vilgaris ; Prunus cerasus ) is an essential component. From the viewpoint of the moisturizing effect, it is preferable to use a fruit as the site of use when obtaining the cherry cherry extract. The sumi cherry extract can be blended in an amount of 0.001 to 7.0% by weight based on the total amount of the external preparation for skin.

  Examples of the plant extract having an astringent effect used in the present invention include bilberry extract, Dutch pepper extract, green tea extract, horsetail extract, clematis extract, buckwheat extract, malonie extract, cinnamon extract, aloe extract , Hamamelis extract, rosemary extract, citrus extract, lavender extract, eucalyptus extract, hop extract, birch extract, chamomile extract, tormentilla extract, sage extract, salvia extract, melissa extract, Altea extract, Hypericum extract, Acacia extract, Gentian extract, Pine bark extract, Plum extract, Peppermint extract, Horseshoe extract, Ibukitorano extract, Butcher bloom extract, Arnica extract, Hypericum extract , Achillea millefolium extract One or more selected from the toe calendula extract, especially white birch extract, it is preferable to use one or two kinds selected from green tea extract.

  The blending amount of the plant extract having an astringent effect in the present invention with respect to the external preparation for skin is preferably 0.001 to 5% by weight, particularly 0.01 to 1% by weight. If it is this range, it will not affect the temporal stability of a formulation and the plant extract in a formulation, and a higher effect can be exhibited.

  Next, a method for extracting a plant extract used in the present invention will be described.

  In the present invention, each of the above plants may be subjected to an extraction operation in a raw state. However, in consideration of extraction efficiency, it is preferable to perform extraction after processing such as shredding, drying, and pulverization. Extraction is performed by immersing in an extraction solvent. In order to increase extraction efficiency, stirring may be performed or homogenization may be performed in an extraction solvent. The extraction temperature is suitably about 5 ° C. to the boiling point of the extraction solvent. The extraction time varies depending on the type of extraction solvent and the extraction temperature, but is suitably about 4 hours to 14 days. Moreover, the extraction method using a supercritical fluid and a subcritical fluid can also be taken.

  As an extraction solvent, water, lower alcohols such as methanol, ethanol, propanol, and isopropanol, polyhydric alcohols such as 1,3-butylene glycol, propylene glycol, dipropylene glycol, and glycerin, diethyl ether, dipropyl ether, and the like Polar organic solvents such as ethers, esters such as ethyl acetate and butyl acetate, ketones such as acetone and ethyl methyl ketone, physiological saline, phosphate buffer, phosphate buffered saline, or petroleum ether , N-hexane, n-pentane, n-butane, n-octane, cyclohexane and other hydrocarbons, carbon tetrachloride, chloroform, dichloromethane, trichloroethylene, benzene, toluene and other nonpolar or low polarity solvents 1 Prefers seeds or two or more solvents It can be used for. In addition, a supercritical fluid such as water, carbon dioxide, ethylene, propylene, ethanol, methanol, ammonia, or a subcritical fluid may be used for extraction. In this case, the above-mentioned solvent may be used as an entrainer. Among these extraction solvents, it is particularly preferable to use water or an aqueous ethanol solution.

  In addition, the extract can be added to the topical skin preparation as it is, but the concentrated and dried solids are dissolved again in water and a polar solvent, or purification treatment such as decolorization, deodorization and desalting, and fractionation treatment are performed. It may be used later. For storage, it is preferable to freeze-dry after the purification treatment and dissolve in a solvent before use. Alternatively, they can be encapsulated in vesicles such as liposomes, microcapsules and the like.

  The external preparation for skin according to the present invention can be provided in various dosage forms such as lotions, emulsions, gels, creams, ointments, powders, granules and the like. In addition, skin cosmetics such as lotion, milky lotion, cream, beauty essence, packs, foundation cosmetics such as makeup base lotion and makeup base cream, foundations for each dosage form such as emulsion, oily, solid, etc. Makeup cosmetics such as color and teak color, cleansing cream, cleansing lotion, cleansing foam, facial cleanser, body shampoo and other skin cleansers, hair lotion, hair nick, hair cream, hair shampoo, hair rinse, hair treatment, etc. It can also be provided as a cosmetic for hair.

  The external preparation for skin according to the present invention includes general components such as oil components, surfactants, moisturizers, pigments, ultraviolet absorbers, antioxidants, fragrances, antibacterial and antifungal agents in addition to the above essential components. Bioactive ingredients such as pharmaceutical and cosmetic raw materials, skin cell activators, and whitening agents can also be included.

  Further, the features of the present invention will be described in detail by way of examples. Unless otherwise specified, the amounts in the examples are given in weight%.

[Example 1] Skin cream
(1) Beeswaw 6.0 (wt%)
(2) Cetanol 5.0
(3) Reduced lanolin 8.0
(4) Squalane 37.5
(5) Fatty acid glycerin 4.0
(6) Lipophilic glyceryl monostearate 2.0
(7) Polyoxyethylene (20EO)
Sorbitan monolaurate 2.0
(8) Propylene glycol 5.0
(9) Methyl parahydroxybenzoate 0.1
(10) Purified water 29.2
(11) Sumio cherry extract 0.5
(12) Dutch pepper extract 0.5
(13) Fragrance 0.2
Production method: The oil phase components (1) to (7) are mixed, dissolved and made uniform, and heated to 75 ° C. On the other hand, the water phase components (8) to (10) are mixed and dissolved and heated to 75 ° C. Subsequently, after adding an oil phase component to the said water phase component and pre-emulsifying, it emulsifies uniformly with a homomixer. Then, it is cooled, and (11) to (13) are added and mixed at 50 ° C.

[Example 2] Emulsion
(1) Squalane 5.0 (% by weight)
(2) White petrolatum 2.0
(3) Beeswax 0.5
(4) Sorbitan sesquioleate 0.8
(5) Polyoxyethylene oleyl ether (20EO) 1.2
(6) Phytosteryl isostearate 3.0
(7) Methyl paraoxybenzoate 0.1
(8) Propylene glycol 5.0
(9) Purified water 54.7
(10) Carboxyvinyl polymer (1 wt% aqueous solution) 20.0
(11) Potassium hydroxide (10% by weight aqueous solution) 1.0
(12) Sumio cherry extract 0.5
(13) Horsetail extract 1.0
(14) Ethanol 5.0
(15) Fragrance 0.2
Production method: The oil phase components (1) to (6) are mixed and heated to 75 ° C. to dissolve and homogenize. On the other hand, the water phase components (7) to (9) are mixed and dissolved, heated to 75 ° C., and the oil phase component is added and pre-emulsified. After (10) is added, the mixture is uniformly emulsified with a homomixer, and (11) is added to adjust the pH. After cooling, add and mix (12)-(15) at 40 ° C.

[Example 3] Lotion
(1) Ethanol 10.0 (wt%)
(2) 1,3-butylene glycol 20.0
(3) Sumino cherry extract 0.5
(4) Rosemary extract 0.5
(5) Fragrance 0.1
(6) Purified water 68.9
Production method: (1) to (5) are sequentially added to (6) and uniformly mixed and dissolved.

[Example 4] Water-in-oil emulsified emollient cream
(1) Liquid paraffin 30.0 (wt%)
(2) Microcrystalline wax 2.0
(3) Vaseline 5.0
(4) Diglycerin oleate 5.0
(5) Sodium L-glutamate 1.6
(6) L-serine 0.4
(7) Propylene glycol 3.0
(8) 1,3-butylene glycol 5.0
(9) Methyl paraoxybenzoate 0.1
(10) Sumino cherry extract 0.5
(11) Purified water 47.3
(12) Lavender oil 0.1
Production method: (5) and (6) are dissolved in a part of (11) to 50 ° C, and gradually added to (4) heated to 50 ° C with stirring. This was mixed in advance, and uniformly dispersed in (1) to (3) heated and dissolved at 70 ° C, and (7) to (10) were dissolved in the remainder of (11) and heated to 70 ° C. Is added with stirring and emulsified with a homomixer. After cooling, add and mix component (12) at 40 ° C.

[Example 5] Makeup base cream
(1) Purified water 44.95 (wt%)
(2) Squalane 25.0
(3) Polyoxyethylene (20EO) stearic acid
Monoglyceryl 1.0
(4) Ethanol 6.0
(5) Hydrophobized talc 3.0
(6) Hydrophobized titanium oxide 4.0
(7) Cetyl 2-ethylhexanoate 3.3
(8) 2-Ethylhexyl paramethoxycinnamate 2.0
(9) Glycerin 2.0
(10) Titanium mica 5.0
(11) Polyoxyethylene (3EO) alkyl ether 1.2
(12) Oxybenzone 0.5
(13) Magnesium sulfate 0.5
(14) Methyl paraoxybenzoate 0.2
(15) Phenoxyethanol 0.2
(16) Bengala 0.17
(17) Yellow iron oxide 0.16
(18) Silk powder 0.5
(19) Sumio cherry extract 0.1
(20) Birch extract 0.1
(21) Green tea extract 0.1
(22) Perfume 0.02
Production method: The oil phase components (1) to (4) are mixed and heated to 75 ° C. to be uniform. On the other hand, the aqueous phase components (5) to (7) are mixed, heated and dissolved at 75 ° C. to make it uniform, and the pigments (8) to (10) are added to this and dispersed uniformly with a homomixer. Let The oil phase component is added to the water phase component, emulsified with a homomixer, cooled, and the components (11) and (12) are added and mixed at 40 ° C.

[Example 6] Emulsion foundation
(1) Stearic acid 2.0 (wt%)
(2) Squalane 5.0
(3) Octyldodecyl myristate 5.0
(4) Cetanol 1.0
(5) Decaglycerin monoisopalmitate 9.0
(6) Macadamia nut fatty acid phytosteryl 0.5
(7) 1,3-butylene glycol 8.0
(8) Potassium hydroxide 0.1
(9) Methyl paraoxybenzoate 0.1
(10) Purified water 50.5
(11) Titanium oxide 9.0
(12) Talc 7.4
(13) Bengala 0.5
(14) Yellow iron oxide 1.1
(15) Black iron oxide 0.1
(16) Fragrance 0.1
(17) Sumio cherry extract 0.5
(18) Eucalyptus extract 0.1
Production method: The oil phase components (1) to (6) are mixed and heated to 75 ° C. to be uniform. On the other hand, the water phase components (7) to (10) are mixed, heated and dissolved at 75 ° C. to make it uniform, and the pigments (11) to (15) are added thereto and uniformly emulsified with a homomixer. After cooling, the components (16) to (18) are added and mixed at 40 ° C.

[Example 7] Hand cream
(1) Cetanol 4.0 (wt%)
(2) Vaseline 2.0
(3) Liquid paraffin 10.0
(4) Glycerin monostearate 1.5
(5) Polyoxyethylene (60EO)
Glycerol isostearate 2.5
(6) Tocopherol acetate 0.5
(7) Soybean phospholipid 0.5
(8) Glycerin 20.0
(9) Methyl paraoxybenzoate 0.1
(10) Purified water 57.9
(11) Sumio cherry extract 0.5
(12) Atlantic Kizuta Extract 0.5
Production method: The oil phase components (1) to (7) are mixed, dissolved, and heated to 75 ° C. On the other hand, the water phase components (8) to (10) are mixed and dissolved and heated to 75 ° C. Next, the oil phase component is added to the water phase component and pre-emulsified, and then uniformly emulsified with a homomixer and cooled, and the components (11) and (12) are added and mixed at 40 ° C.

[Example 8] Cleansing massage cream
(1) Purified water 22.86 (% by weight)
(2) 1,3-butylene glycol 7.00
(3) Sucrose fatty acid ester 3.00
(4) Sodium N-stearoyl-L-glutamate 0.85
(5) Carboxyvinyl polymer (1 wt% aqueous solution) 15.00
(6) p-Hydroxybenzoate 0.05
(7) Polyglyceryl monolaurate 0.20
(8) Squalane 44.00
(9) Behenyl alcohol 1.20
(10) Lipophilic glyceryl monostearate 1.50
(11) Stearic acid 0.80
(12) Glyceryl triisostearate 1.00
(13) Refined jojoba oil 0.10
(14) Hardened oil 0.30
(15) L-arginine (10% by weight aqueous solution) 1.50
(16) Sumio cherry extract 0.30
(17) Aloe extract 0.30
(18) Perfume 0.04
Production method: The oil phase components (8) to (14) are mixed, heated and dissolved to 80 ° C. On the other hand, the aqueous phase components (1) to (7) are mixed and dissolved by heating to 80 ° C. The oil phase component is gradually added to this water phase component and pre-emulsified, and then uniformly emulsified with a homomixer, (15) is added and mixed, and further cooled and cooled to 50 ° C. at (16) to (18 ) And mix.

[Example 9] Facial cleansing foam
(1) Myristic acid 23.86 (% by weight)
(2) Palmitic acid 3.28
(3) Stearic acid 8.33
(4) Concentrated glycerin 16.00
(5) Lipophilic glyceryl monostearate 3.00
(6) Potassium hydroxide 7.59
(7) Purified water 18.00
(8) 1,3-butylene glycol 3.00
(9) Carboxymethylcellulose sodium 0.03
(10) Palm oil fatty acid amidopropyl betaine solution 3.00
(11) Purified water 13.26
(12) Sumino cherry extract 0.30
(13) Hop extract 0.30
(14) Fragrance 0.05
Production method: The oil phase components (1) to (5) are mixed and dissolved by heating to 80 ° C. On the other hand, the aqueous phase components (6) and (7) are mixed and dissolved by heating to 80 ° C. The oil phase component is gradually added to the water phase component to neutralize and then mixed, and (8) to (11) heated to 75 ° C. are added, and cooled to 50 ° C. at (12) to (12) Add 14) and cool further while mixing.

[Example 10] Cleansing Massage Gel
(1) Purified water 11.34 (wt%)
(2) Concentrated glycerin 14.40
(3) Sucrose fatty acid ester 5.00
(4) Polyoxyethylene glyceryl isostearate 2.00
(5) 1,3-butylene glycol 3.00
(6) Methyl paraoxybenzoate 0.50
(7) Squalane 32.05
(8) Glyceryl tri-2-ethylhexanoate 18.55
(9) Neopentyl glycol dicaprate 9.28
(10) Stearic acid 1.00
(11) Refined jojoba oil 1.00
(12) Hydrogenated soybean phospholipid 1.00
(13) Sumino cherry extract 0.40
(14) Pine bark extract 0.40
(15) Perfume 0.08
Production method: The oil phase components (7) to (12) are mixed and dissolved by heating to 70 ° C. On the other hand, the aqueous phase components (1) to (6) are mixed and dissolved by heating to 70 ° C. The oil phase component is gradually added to the aqueous phase component and pre-emulsified, and then uniformly emulsified with a homomixer, cooled and further added with (13) to (15) and mixed at 50 ° C. Cooling.

[Example 11] Pack
(1) Glyceryl tri-2-ethylhexanoate 3.00 (wt%)
(2) Sorbitan monolaurate 0.30
(3) Sucrose fatty acid ester 0.30
(4) Sorbitan monostearate 0.05
(5) Concentrated glycerin 5.00
(6) Polyethylene glycol (average molecular weight 1540) 3.00
(11) Methyl paraoxybenzoate 0.02
(13) Purified water 7.00
(14) Alkaligenes-producing polysaccharide (0.25 wt% aqueous solution) 1.00
(15) Polyvinyl alcohol 12.90
(16) Silicic anhydride 0.06
(17) Ethanol 10.30
(18) Purified water 56.87
(22) Sumio cherry extract 0.10
(23) Hamelis extract 0.10
Production method: The aqueous phase components (10) to (14) are mixed and dissolved by heating to 80 ° C. On the other hand, the oil phase components (1) to (9) are mixed and dissolved by heating to 80 ° C. The aqueous phase component is gradually added to this oil phase component and pre-emulsified, and then uniformly emulsified with a homomixer. (15) to (18) are mixed, dissolved by heating to 80 ° C. and then cooled, and (19), (20) and the emulsion are added and mixed at 50 ° C. Next, (21) to (29) are added, mixed, and further cooled.

[Examples 12 to 15 and Comparative Examples 1 to 3] Cosmetic liquid (1) Beeswax 6.00 (% by weight)
(2) Cetanol 5.00
(3) Reduced lanolin 8.00
(4) Squalane 27.50
(5) Glyceryl fatty acid ester 4.00
(6) Lipophilic glyceryl monostearate 2.00
(7) Polyoxyethylene (20E.O.)
Sorbitan monolaurate 5.00
(8) Propylene glycol 5.00
(9) Methyl paraoxybenzoate 0.10
(10) Purified water Amount that makes the total amount 100 (11) Components listed in Table 1 Quantity manufacturing methods listed in Table 1: The oil phase components of (1) to (7) are mixed and dissolved by heating to 75 ° C. On the other hand, the water phase components (8) to (10) are mixed, dissolved, and heated to 75 ° C. Next, the oil phase component is added to the aqueous phase component and pre-emulsified, and then uniformly emulsified with a homomixer. After cooling, (11) is added and mixed at 40 ° C.

  About the Example 12-Example 15 and the comparative example 1-comparative example 3 of the said invention, the rough skin improvement effect was examined. A group of 10 healthy persons aged 25 to 50 years old were photographed with a microscope for the skin condition before causing experimental rough skin, and the score was determined according to the criteria shown in Table 2. Experimental rough skin was induced by treating the inner side of the upper arm with a mixture of ether and acetone (1: 1 volume ratio). Thereafter, the test serum was applied twice a day in the morning and at night every day for 7 days, and the skin condition score was determined as described above 1 day and 7 days after the occurrence of rough skin. At the same time, the water content of the stratum corneum applied site was measured 1 day and 7 days after the occurrence of rough skin. The stratum corneum moisture content was shown by the measured value (μS) of skin surface conductance. The results are shown in Table 1.

  As shown in Table 1, by applying the cosmetic liquids of Examples 12 to 15 according to the present invention containing a combination of a cherry tree extract, a birch extract, and a green tea extract to the skin, an effect of improving rough skin can be obtained. It became clear that the amount of keratin moisture increased. On the other hand, in Comparative Examples 1 to 3 in which the cismino cherry extract, birch extract, and green tea extract were blended alone, improvement in rough skin and an increase in the amount of keratin water were observed, but the improvement effect was in the examples. In comparison with the above, the improvement effect of the example was remarkable.

  In addition, for each sample used in this use test, no skin irritation or skin abnormality was observed.

  Moreover, about each sample of an Example, evaluation that the familiarity was good about all was obtained.

  In each example of the present invention, no change in state such as coloring, odor, aggregation, precipitation or deposition of content components, or phase separation was observed when stored at 25 ° C. for 6 months.

Claims (2)

A skin external preparation comprising a combination of a cherry tree extract and a plant extract having an astringent effect. The skin external preparation according to claim 1, wherein the plant extract having an astringent effect is one or two selected from birch extract and green tea extract.