JP2011042613A - Anti-aging skin care preparation and anti-aging cosmetic - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an anti-aging skin care preparation that sufficiently permeates and stores a substance for promoting a collagen production in the skin and fundamentally improves wrinkles and flabbiness, and an anti-aging cosmetic. <P>SOLUTION: The anti-aging skin care preparation and the anti-aging cosmetic each comprise (A) a synthetic peptide constituted of 3-8 amino acids or its derivative and (B) hydrolyzed collagen having a molecular weight of 500-5,000 or its derivative. <P>COPYRIGHT: (C)2011,JPO&INPIT

Description

  The present invention relates to an anti-aging skin external preparation and an anti-aging cosmetic. More specifically, component (A) a synthetic peptide composed of 3 to 8 amino acids as an active ingredient or a derivative thereof, and component (B) hydrolyzed collagen or a derivative thereof having a molecular weight in the range of 500 to 5000 It is related with the anti-aging skin external preparation and anti-aging cosmetics to contain, It is related with the skin external preparation or cosmetics which exhibit anti-aging use by accelerating | stimulating the collagen production in skin.

  Various changes occur in the skin as it ages. Among them, wrinkles and sagging are conspicuous in appearance, and there is a strong demand for prevention and improvement. This is mainly due to a decrease in the extracellular matrix in the dermis, especially collagen. The amount of collagen in the skin tends to decrease with aging, and a decrease of about 65% is recognized between the ages of 20 and 80. This is due to the decrease in the amount of collagen synthesis in fibroblasts with aging and the enhancement of the collagen degradation system (Non-patent Document 1).

  Various studies have been conducted to suppress these changes. Products that apply collagen itself for external or internal use have been widely marketed. Moreover, for example, in Patent Document 1, wrinkles and elasticity are prevented from being suppressed by suppressing collagenase, which is an enzyme involved in collagen degradation. In recent years, a technique for promoting collagen production in the skin itself has been developed as a more active improvement method. For example, Patent Literature 2 discloses that vitamin A and vitamin D are used in combination to promote collagen production. Patent Document 3 discloses that pollen, pollen cargo and extracts thereof have an effect of promoting production of at least one of collagen and hyaluronic acid.

Dermatology MOOK No.20 Aging and skin 1995 80-85

JP 2000-26228 A JP 2004-175731 A JP 2008-133270 A

  However, topical use of collagen, internal use and collagenase suppression are not fundamental solutions for suppressing wrinkles and sagging. Moreover, in the technology for promoting collagen production, for example, vitamin A and vitamin D may cause skin irritation, and because they are unstable substances, special formulation technology is required, and a sufficient amount is required. It was difficult to mix. In addition, the method of administering pollen and its extract does not require special formulation technology, but it is not expected to have a significant effect from the viewpoint of stability on skin, penetration and storage, and it is a fundamental solution. The current situation has not yet been reached. That is, there has been no anti-aging skin external preparation or cosmetic material that sufficiently penetrates and stores a substance that promotes collagen production into the skin and fundamentally improves wrinkles and sagging.

  As a result of searching for effective substances that prevent and improve changes in the skin such as wrinkles and sagging, the present inventor has found that the component (A) is a synthetic peptide composed of 3 to 8 amino acids or a derivative thereof, (B) Focusing on hydrolyzed collagen having a molecular weight in the range of 500 to 5000 or a derivative thereof, combining these, specifically confirming that it has an effect of promoting collagen production, and improving wrinkles and sagging It was successful and the present invention was completed.

  That is, the present invention contains a component (A) a synthetic peptide composed of 3 to 8 amino acids or a derivative thereof, and a component (B) a hydrolyzed collagen having a molecular weight in the range of 500 to 5000 or a derivative thereof. An anti-aging skin external preparation is provided. In addition, for component for anti-aging, comprising component (A) a synthetic peptide composed of 3 to 8 amino acids or a derivative thereof, and component (B) hydrolyzed collagen having a molecular weight in the range of 500 to 5000 or a derivative thereof It provides cosmetics. Furthermore, the present invention provides the anti-aging skin external preparation or the anti-aging cosmetic composition characterized by promoting collagen production.

  The anti-aging skin external preparation and anti-aging cosmetic composition of the present invention have a low molecular weight and combine directly with active ingredients having excellent skin permeability and storage properties, thereby acting directly on in vivo fibroblasts. It is intended to prevent and improve fundamental wrinkles and sagging to promote collagen production.

  Hereinafter, preferred embodiments for carrying out the present invention will be described. In addition, embodiment described below shows an example of typical embodiment of this invention, and, thereby, the range of this invention is not interpreted narrowly.

  The synthetic peptide of component (A) or a derivative thereof used in the present invention is an oligopeptide in which 3 to 8 amino acids are bound by a peptide bond. The type of the constituent amino acid is not particularly limited, but is preferably selected from continuous amino acid sequences of telopeptides contained in the structure of procollagen. In addition, the synthetic peptide of component (A) may be derivatized by alkylation, acylation, formylation, etc. in order to improve the permeation retention property, safety and stability to the skin. . Among them, it is preferable to use a branched or straight chain acyl group having 5 to 20 carbon atoms.

  In the anti-aging skin external preparation and anti-aging cosmetic according to the present invention, the blending amount of the synthetic peptide of component (A) and its derivative is not particularly limited, and can be freely set according to the purpose. The solid content is preferably 0.0001% by mass (hereinafter simply referred to as “%”) or more and 5% or less, more preferably 0.001% or more and 3% or less. When the component (A) is contained within this range, the active ingredient can be stably blended and a high collagen production promoting effect can be exhibited.

  The hydrolyzed collagen of component (B) or a derivative thereof used in the present invention is obtained by degrading collagen with a protease enzyme or the like and fractionating the molecular weight from 500 to 5000. The type of collagen is not particularly limited, and any of type I to XIII or a mixed type can be used. Choose the origin of collagen from animals (eg, cows, pigs, chickens, etc.) and fish (eg, flounder, salmon, sardines, tuna, etc.) and extraction sites from bones, skins, tendons, duckweeds (fishes), etc. Is possible. Furthermore, as the component (B) hydrolyzed collagen, derivatized products such as acylation and succinylation can be used in order to improve the osmotic retention property, safety and stability to the skin.

The molecular weight in the present invention is measured by a gel filtration method using high performance liquid chromatography, and more specifically indicates an average molecular weight when Peptide Column is used as a column.

  In the anti-aging skin external preparation and anti-aging cosmetic according to the present invention, the amount of the hydrolyzed collagen of component (B) or a derivative thereof is not particularly limited and can be freely set according to the purpose. However, it is preferable to contain 0.0001% or more and 5% or less as solid content, respectively, and it is more preferable to contain 0.001% or more and 3% or less. When the component (B) is contained within this range, the active ingredient can be blended stably and a high collagen production promoting effect can be exhibited.

  The anti-aging skin external preparation according to the present invention can be applied to external preparations of any dosage form. For example, it can be applied to external preparations such as external preparations, external preparations, creams, ointments, sprays, nasal drops, liniments, lotions, haps, plasters, sprays, aerosols, etc. .

  One or more pharmacologically acceptable additives can be freely selected and contained in the anti-aging skin external preparation according to the present invention. For example, bases, surfactants, preservatives, emulsifiers, colorants, flavoring agents, fragrances, stabilizers, preservatives, antioxidants, lubricants, solubilizers, suspending agents, oils, thickeners All additives that can be usually used in the field of pharmaceutical preparations, such as chelating agents, enzymes, and pH adjusting agents can be contained.

  Moreover, the anti-aging skin external preparation which concerns on this invention can also select all the existing chemical | medical agents and medicinal components freely, or can also be used as a mixture. For example, antioxidants, anti-inflammatory agents, cell activators, UV inhibitors, moisturizers, blood circulation promoters, antibacterial agents, analgesics, steroids, antifungal agents, antitussives, antihistamines, vitamins, antitumor agents, etc. Any drug can be formulated.

  The anti-aging cosmetic according to the present invention can be applied to cosmetics of all forms. For example, skin care cosmetics such as facial cleansers, lotions, milky lotions, creams, beauty liquids, foundations, concealers, makeup bases, makeup cosmetics such as lipsticks, blushers, eye shadows, eyeliners, sunscreen cosmetics, body makeup It can be applied to fees.

  In the anti-aging cosmetic according to the present invention, it is possible to freely select one or two or more components that can be usually used in cosmetics and mix them. For example, bases, preservatives, emulsifiers, colorants, preservatives, surfactants, UV absorbers, antioxidants, moisturizers, UV absorbers, fragrances, antiseptic / antifungal agents, extender pigments, colored pigments, alcohol, All additives that can be usually used in the cosmetic field, such as polyhydric alcohol, water, oil agent, thickener, powder, chelating agent, enzyme, pH adjuster, and the like can be contained.

  Among these drugs and medicinal components, typical ones are specifically exemplified below. Here, the “derivative” is a concept including a formable ester or salt. Moreover, since the same component may have a some medicinal effect, in that case, the same name is described to a some medicine and medicinal component. In the case of plants, the names of other herbal medicines are also listed in parentheses.

  Examples of antioxidants include vitamin E and its derivatives, vitamin C and its derivatives, carotenoids, dibutylhydroxytoluene, butylhydroxyanisole, rutin and its derivatives, glutathione and its derivatives, superoxide dismutase, mannitol, caquette extract, Genokosho extract, Hawthorn extract, Peonies extract, Ginkgo biloba extract, Koganebana (Ougon) extract, Maikaika (Maikai, Hermanus) extract, Tormentilla extract, grape extract, Yashajitsu (Yasha) extract, Yukinoshita extract , Rosemary (mannenrou) extract, tea extract (Oolong tea, black tea, green tea, etc.).

  Examples of anti-inflammatory agents include steroids and derivatives thereof, indomethacin, azulene and derivatives thereof, glycyrrhizic acid and derivatives thereof, glycyrrhetinic acid and derivatives thereof, sulfur and derivatives thereof, aloe extract, extract of Ashitaba, nettle extract, inchinkou (Coleoptera) extract, Turmeric extract, Yellowfin extract, Hypericum extract, Chamomile extract, Comfrey extract, Honeysuckle extract, Watercress extract, Salvia (Sage) extract , Walnut extract, perilla extract, white birch extract, elder extract, larva extract, mugwort extract, eucalyptus extract, mugwort extract, forsythia extract, Kumazasa extract, zinc oxide, etc. Is mentioned.

  Examples of cell activators include vitamin A and its derivatives, asparagus extract, soybean extract, jujube extract, garlic extract, carrot extract, beech extract, royal jelly, yeast extract, microbial fermentation Examples include metabolites and ganoderma extract.

  Examples of UV inhibitors include paramethoxycinnamate-2-ethylhexyl, 4-tert-butyl-4′-methoxydibenzoylmethane, oxybenzone and derivatives thereof, titanium oxide, fine particle titanium oxide, zinc oxide and fine particle zinc oxide. Etc. When inorganic powders such as titanium oxide and zinc oxide are fine particles, higher effects are exhibited.

  Examples of humectants include glycerin, 1,3-butylene glycol, proteins or derivatives or hydrolysates thereof, and salts thereof (collagen other than components (A) and (B) of the present invention, elastin, etc.), hyaluron Acids and salts thereof, amino acids and derivatives thereof, saccharides, D-panthenol and derivatives thereof, glycolipids, phospholipids, ceramides, urea, mucins, almond extracts, avocado extracts, altea extracts, hot spring water, aloe extracts , Usvenia oyster extract, Ononis extract, oat extract, glabrizine, glabrene, liquiritin, isoliquiritin and licorice extract containing these, quince seed extract, clara extract, gardenia extract, grapefruit extract, Watercress extract, gentian extract, Genno Yoko extract, Burdock extract, Wheat extract, Saisin extract, Cactus extract, Savonso extract, Hawthorn extract, Giant extract, Shimotake extract, Ginger extract, Mallow (Mushroom) extract, Mulberry (Sowahakuhi) extract, Tachikaku Sou (time) extract, Cordyceps extract, Dokudami extract, mint extract, pearl barley extract, Hamelis extract, rose extract, cypress extract, dandelion extract, grape extract, Prune extract, Loofah extract, Bodaige extract, Hop extract, Pine extract, Quince extract, Maroni extract, Melissa extract, Cornflower extract, Lily extract, Lime extract, Lavender extract, Apple extract Products, rice and rice bran extract, black currant extract, ibukitorano extract, Ibarra (rose fruit) extract, Siberian ginseng extract, and the like seaweed extract. Examples of moisturizing (emollient) agents by sealing the skin surface include jojoba oil, macadamia nut oil, olive oil, apricot oil, peach seed oil, safflower oil, sunflower oil, avocado oil, medhome oil, camellia oil, almond oil , Sesame oil, sesame oil, borage (borage) oil, cacao butter, shea butter and the like.

  Examples of the blood circulation promoter include vitamin E and its derivatives, yuzu extract, arnica extract, chili tincture, ginger tincture, ginger extract, γ-oryzanol and the like.

  Hereinafter, the present invention will be described in more detail based on examples. In addition, the Example demonstrated below shows an example of the typical Example of this invention, and, thereby, the range of this invention is not interpreted narrowly.

<Experiment 1: Collagen production promoting effect>
In Experiment 1, a synthetic peptide having a specific molecular weight and derivatives thereof, and a collagen production promoting effect of hydrolyzed collagen having a specific molecular weight and derivatives thereof were examined.

(1) Synthetic peptide of component (A) Five consecutive amino acid sequences selected from telopeptides at the C-terminal of collagen were synthesized, and a solid material having a palmitoyl group introduced into this pentapeptide was used.

(2) Hydrolyzed collagen of component (B) Fish-derived collagen was decomposed with protease, the decomposed product was subjected to column purification, and a freeze-dried product having a molecular weight of about 700 was used.

(3) Cell culture conditions After normal human neonatal fibroblasts were precultured, 0.01 w / v% of the synthetic peptide and 0.05 w / v% of the hydrolyzed collagen were added to the medium. Cells seeded in the same number in a petri dish under medium conditions were aseptically cultured for one week under conditions of high humidity, 5% CO ₂ and 37 ° C. As a positive control, 0.1% w / v of magnesium ascorbate phosphate, a vitamin C derivative known to promote collagen production, and 0.01% w / v synthetic peptide as a comparative control of synergistic effect. Used only, 0.05 w / v% of the hydrolyzed collagen alone was added, and a negative control was grown only on the medium.

(4) Measurement of collagen production After culture, the medium in the petri dish was removed, washed once with PBS (−), and then fixed with 4% paraformaldehyde at room temperature for 1 hour. The fixed cells were washed thoroughly with PBS (−), blocked with PBS (−) containing 1% skin milk for 1 hour at room temperature, washed once with PBS (−), and then washed with procollagen. The primary antibody (manufactured by CHEMICON) was diluted to 1/200 with PBS (−) and added. The antibody reaction was carried out at room temperature for 1 hour, and after washing thoroughly with PBS (−), a secondary antibody (manufactured by Invitrogen) labeled with a fluorescent substance was diluted 1/1000 with PBS (−) and added. The antibody reaction is performed at room temperature for 1 hour, washed once with PBS (−), then observed with a fluorescence microscope, the obtained fluorescence image is captured, and the fluorescence intensity of the captured image is measured using image analysis software. The amount of collagen was calculated.

(5) Results Table 1 shows collagen production amounts calculated from collagen fluorescence images in fibroblasts grown under each culture condition. The synthetic peptide alone has almost no collagen production promoting effect, and the hydrolyzed collagen alone was almost the same as the positive control magnesium ascorbate phosphate, whereas the synthetic peptide and the hydrolyzed collagen were combined. Were found to promote collagen production far exceeding the production of collagen alone.

[Example 1: Hydrophilic ointment for anti-aging]
A hydrophilic ointment for anti-aging was prepared by the following method.
(Manufacturing method)
A. A part of the following components (3), (4) and (10) were mixed by heating and kept at 75 ° C.
B. The following components (1), (2) and (8) were heated and mixed and kept at 75 ° C.
C. B is gradually added to A, and components (5), (6) and (7) dissolved in the remainder of component (9) are added while cooling this to obtain a hydrophilic ointment for anti-aging according to Example 1 It was.

Ingredient%
(1) Stearic acid 18.0
(2) Cetanol 4.0
(3) Triethanolamine 2.0
(4) Glycerin 5.0
(5) Synthetic peptide 1.0
(6) Hydrolyzed collagen 1.0
(7) Dipotassium glycyrrhizinate (Nippon Roche Co., Ltd.) 0.5
(8) Acetic acid dl-α-tocopherol (manufactured by Eisai Co., Ltd.) 0.2
(9) Methyl paraoxybenzoate 0.1
(10) Purified water remaining

(effect)
The ointment according to Example 1 was excellent in stability over time and applied to the skin to promote collagen production in the skin, thereby improving wrinkles and sagging.

[Example 2: Happ agent]
An anti-aging haptic agent was prepared by the following method.
(Manufacturing method)
A. The following components (1), (3), (4), (7) to (9) and (11) were mixed and stirred while maintaining at 70 ° C.
B. The following components (2) and (10) were mixed.
C. The above B was added to the previous A, mixed, and then cooled to uniformly disperse the components (5) and (6) to obtain a haptic agent according to Example 2.

Ingredient%
(1) Polyvinyl alcohol 20.0
(2) Ethanol 20.0
(3) Glycerin 5.0
(4) Kaolin 6.0
(5) Synthetic peptide 0.05
(6) Hydrolyzed collagen 0.05
(7) Resorcin * Note 1 0.02
(8) Riboflavin * Note 0.1
(9) Tranexamic acid * Note 1 0.5
(10) Preservative 0.2
(11) Remaining amount of purified water * Note 1: Sigma Aldrich Japan Co., Ltd.

(effect)
The haptic agent according to Example 2 was a haptic agent that was excellent in stability over time and applied to the skin to promote collagen production in the skin, thereby improving wrinkles and sagging.

[Example 3: Cream for anti-aging]

(Manufacturing method)
A. Components (1) to (8) were dissolved by heating and kept at 70 ° C.
B. Components (9) to (13) were dissolved by heating and maintained at 70 ° C.
C. B was added to A, mixed and uniformly emulsified.
D. C was cooled, component (14) was added and mixed, and anti-aging creams of Example 3 and Comparative Examples 1 and 2 were obtained.

Evaluation method (wrinkle improvement, sagging improvement)
Using the above-mentioned anti-aging cream, an actual use test for 2 months was conducted. Thirty women in their 40s to 50s were used as panels, and 10 examples each were used blindly in Examples and Comparative Examples. Observe skin condition before start of use test and after end of use test, markedly improved for each item of wrinkles and sagging: 3 points Improved: 2 points Somewhat improved: 1 point No change: 0 points Deteriorated: -1 point The average value was calculated and the results are shown together in Table 2.

  As shown in Table 2, the examples of the present invention showed much better wrinkle and sagging improvement effects than the comparative examples in which the active ingredients were added alone.

[Example 4: lotion]
A lotion was prepared by the following production method.
(Manufacturing method)
A. The following components (1) to (9) were mixed and dissolved.
B. The following components (10) to (18) were mixed and dissolved.
C. A lotion according to Example 3 was obtained by adding B to A and mixing uniformly.

Ingredient%
(1) Glycerol 3.0
(2) 1,3-butylene glycol 2.0
(3) Propylene glycol 4.0
(4) Oleyl alcohol 0.5
(5) Polyoxyethylene monolaurate (20)
Sorbitan 1.5
(6) Polyoxyethylene (20)
Lauryl ether 0.5
(7) Squalane 0.5
(8) Ethanol 20.0
(9) Methyl paraoxybenzoate 0.1
(10) Peonies extract (Inabata Fragrance Co., Ltd.) 0.5
(11) Birch bark extract (Ichimaru Falcos Co., Ltd.) 0.5
(12) Rosemary extract (Maruzen Pharmaceutical Co., Ltd.) 0.5
(13) Pine extract (Maruzen Pharmaceutical Co., Ltd.) 0.2
(14) Locust bean gum 1.0
(15) Yokuinin extract (Maruzen Pharmaceutical Co., Ltd.) 0.5
(16) The synthetic peptide 0.1
(17) Hydrolyzed collagen 0.1
(18) Purified water remaining

(effect)
The lotion according to Example 4 was a lotion that was excellent in stability over time and applied to the skin to promote collagen in the skin, thereby improving wrinkles and sagging.

[Example 5: Cleansing cream]
A cleansing cream was prepared by the following method.
(Manufacturing method)
A. The following components (1) to (9) were dissolved by heating and kept at 70 ° C.
B. The following components (10) to (15) were dissolved by heating and kept at 70 ° C.
C. B was added to A, mixed and uniformly emulsified.
D. C was cooled, the following component (16) was added and mixed, and the cleansing cream according to Example 5 was obtained.

Ingredient%
(1) Paraffin wax 10.0
(2) Beeswax 3.0
(3) Vaseline 15.0
(4) Liquid paraffin 41.0
(5) Sorbitan sesquioleate 4.2
(6) Polyoxyethylene monooleate (20)
Sorbitan 0.8
(7) Hydrogenated soybean phospholipid 0.5
(8) Medhoo Home Oil (Nippon Surfactant Kogyo Co., Ltd.) 1.0
(9) Methyl paraoxybenzoate 0.1
(10) Quince seed extract (manufactured by Koei Kogyo Co., Ltd.) 1.0
(11) Savonso extract (manufactured by Maruzen Pharmaceutical Co., Ltd.) 1.0
(12) Maltose 1.0
(13) The synthetic peptide 0.75
(14) Hydrolyzed collagen 0.75
(15) Purified water remaining amount (16) Perfume appropriate amount

(effect)
The cleansing cream according to Example 5 was a cleansing cream that was excellent in aging stability and improved wrinkle and sagging by promoting collagen production in the skin when applied to the skin.

[Example 6: Latex]
An emulsion was prepared by the following production method.
(Manufacturing method)
A. The following components (13) to (24) were dissolved by heating and kept at 70 ° C.
B. The following components (1) to (12) were dissolved by heating and kept at 70 ° C.
C. B was added to A, mixed and uniformly emulsified.
D. C was cooled, the following components (25) and (26) were added and mixed, and an emulsion according to Example 6 was obtained.

Ingredient%
(1) Sorbitan monostearate 0.3
(2) Polyoxyethylene monooleate (20)
Sorbitan 0.1
(3) Lipophilic glyceryl monostearate 0.2
(4) Stearic acid 0.5
(5) Cetanol 0.5
(6) Squalane 3.0
(7) Liquid paraffin 4.0
(8) Glyceryl tri-2-ethylhexanoate 2.0
(9) Dimethylpolysiloxane 1.0
(10) Hydrogenated soybean phospholipid 0.1
(11) Methyl paraoxybenzoate 0.1
(12) Carboxyvinyl polymer 0.1
(13) Sodium hydroxide 0.05
(14) Glycerin 5.0
(15) 1,3-butylene glycol 7.0
(16) The synthetic peptide 0.25
(17) Hydrolyzed collagen 0.25
(18) Purified water remaining amount (19) Ethanol 5.0
(20) Yeast extract (BIO-DELL) 0.5
(21) Hydrolyzed black bean extract (Technoble) 0.5
(23) Hop extract (Maruzen Pharmaceutical Co., Ltd.) 0.5
(24) Ezoukogi extract (Maruzen Pharmaceutical Co., Ltd.) 0.5
(25) Porous silica 3.0
(26) Appropriate amount of perfume

(effect)
The emulsion according to Example 6 was excellent in stability over time, and was an emulsion that improved wrinkle and sagging by promoting collagen production in the skin when applied to the skin.

[Example 7: Pack]
A pack was prepared by the following production method.
(Manufacturing method)
A. The following components (1) to (7) were mixed and dissolved by heating at 70 ° C.
B. The following components (8) to (12) were mixed and dissolved.
C. The following components (13) to (18) were mixed and dissolved.
D. B was added to A and mixed and cooled, then C was added and mixed to obtain a pack according to Example 7.

Ingredient%
(1) Polyvinyl alcohol 15.0
(2) Silicic anhydride 0.5
(3) Polyethylene glycol 0.5
(4) Jojoba oil (manufactured by Higher Alcohol Industry Co., Ltd.) 0.2
(5) Polyoxypropylene (10) methyl glucoside 5.0
(6) Glycerin 5.0
(7) Purified water remaining amount (8) Ethanol 15.0
(9) Rice bran extract (manufactured by Koei Kogyo Co., Ltd.) 1.0
(10) Hermanus extract (Maruzen Pharmaceutical Co., Ltd.) 1.0
(11) Anhydrous caffeine (manufactured by Pure Chemical Industries, Ltd.) 1.0
(12) Phosphoric acid-L-ascorbyl magnesium (manufactured by Nikko Chemicals Co., Ltd.) 3.0
(13) Synthetic peptide 0.2
(14) Hydrolyzed collagen 0.2
(15) Purified water 5.0
(16) Ethanol 15.0
(17) Ethyl paraoxybenzoate 0.1
(18) Perfume appropriate amount

(effect)
The pack according to Example 7 was a pack that was excellent in stability over time and improved wrinkle and sagging by promoting collagen production in the skin when applied to the skin.

[Example 8: Cream foundation (O / W type)]
A cream foundation was prepared by the following production method.
(Manufacturing method)
A. The following components (1) to (11) were mixed by heating and maintained at 70 ° C.
B. The following components (12) to (18) were mixed by heating and kept at 70 ° C.
C. B was added to A, mixed and uniformly emulsified.
D. After cooling C, the following component (19) was added and mixed to obtain a cream foundation (O / W type) according to Example 8.

Ingredient%
(1) Sorbitan sesquioleate 3.0
(2) Self-emulsifying glyceryl monostearate 2.0
(3) Aluminum stearate 0.5
(4) Ceresin wax 5.0
(5) Squalane 10.0
(6) Liquid paraffin 15.0
(7) Vaseline 5.0
(8) Titanium oxide 8.0
(9) Talc 4.0
(10) Coloring pigment appropriate amount (11) Methyl paraoxybenzoate 0.1
(12) Propylene glycol 5.0
(13) Primrose extract (Ichimaru Falcos) 1.0
(14) Cocoa extract (Maruzen Pharmaceutical Co., Ltd.) 1.0
(15) Maronnier extract (manufactured by Koei Kogyo Co., Ltd.) 1.0
(16) The synthetic peptide 0.05
(17) Hydrolyzed collagen 0.1
(18) Purified water remaining amount (19) Perfume appropriate amount

(effect)
The cream foundation according to Example 8 was a cream foundation that was excellent in stability over time and applied to the skin to promote collagen production in the skin, thereby improving wrinkles and sagging.

[Example 9: Daytime serum]
A daytime serum was prepared by the following method.
(Manufacturing method)
A. The following components (1) to (9) were mixed and dissolved.
B. The following components (21) to (23) were added to A, mixed uniformly, and kept at 70 ° C.
C. The following components (10) to (20) were uniformly dissolved and kept at 70 ° C.
D. B was added to C and emulsified.
E. After cooling D, the following component (24) was added and mixed to obtain a daytime cosmetic liquid according to Example 9.

Ingredient%
(1) Liquid lanolin 2.0
(2) Liquid paraffin 5.0
(3) Stearic acid 2.0
(4) Cetanol 1.0
(5) Self-emulsifying glyceryl monostearate 1.0
(6) Paramethoxycinnamic acid-2-ethylhexyl 8.0
(7) 4-tert-butyl-4′-methoxy dibenzoylmethane 2.0
(8) Retinol palmitate (Nippon Roche Co., Ltd.) 0.2
(9) Methyl paraoxybenzoate 0.1
(10) Glycerin 5.0
(11) Triethanolamine 1.0
(12) Carboxymethylcellulose 0.2
(13) Bentonite 0.5
(14) White birch extract (manufactured by Maruzen Pharmaceutical Co., Ltd.) 5.0
(15) Purified water remaining amount (16) Glycosyl trehalose (Hayashibara Biochemical Laboratories) 5.0
(17) Asparagus extract (Maruzen Pharmaceutical Co., Ltd.) 0.5
(18) Licorice extract (Maruzen Pharmaceutical Co., Ltd.) 0.5
(19) Synthetic peptide 0.2
(20) Hydrolyzed collagen 0.4
(21) Fine particle titanium oxide 2.0
(22) Fine zinc oxide 5.0
(23) Nylon powder 1.0
(24) Perfume appropriate amount

(effect)
The daytime cosmetic liquid according to Example 9 was excellent in stability over time, and applied to the skin to promote collagen production in the skin, thereby improving wrinkles and sagging.

[Example 10: Sunscreen emulsion (W / O type)]
A sunscreen emulsion was prepared by the following method.
(Manufacturing method)
A. The following components (1) to (10) were mixed and kept at 70 ° C.
B. A part of the following components (11) to (13) and (14) was mixed and kept at 70 ° C.
C. B was added to A and emulsified uniformly.
D. After cooling C, the remainder of component (14) and the following components (15) to (20) were added and mixed to obtain a sunscreen emulsion (W / O type) according to Example 10.

Ingredient%
(1) Polyoxyalkylene-modified organopolysiloxane 1.0
(2) Dimethylpolysiloxane 5.0
(3) Octamethylcyclotetrasiloxane 20.0
(4) Isotridecyl isononanoate 5.0
(5) Paramethoxycinnamic acid-2-ethylhexyl 5.0
(6) Methyl paraoxybenzoate 0.1
(7) Silicone-treated fine particle titanium oxide 10.0
(8) Silicone-treated fine particle zinc oxide 10.0
(9) Polystyrene powder 3.0
(10) Trimethylsiloxysilicate 0.5
(11) Dipropylene glycol 3.0
(12) Ethanol 10.0
(13) Sodium chloride 0.2
(14) Purified water remaining amount (15) β-carotene 0.01
(16) Chamomile extract (Maruzen Pharmaceutical Co., Ltd.) 1.0
(17) Warmoko extract (Maruzen Pharmaceutical Co., Ltd.) 1.0
(18) Synthetic peptide 0.5
(19) Hydrolyzed collagen 1.0
(20) Perfume appropriate amount

(effect)
The sunscreen emulsion according to Example 10 is a sunscreen emulsion (W / O type) that is excellent in stability over time and improves wrinkle and sagging by promoting collagen production in the skin when applied to the skin. there were.

Claims (4)

  Component (A) A synthetic peptide composed of 3 to 8 amino acids or a derivative thereof, and component (B) hydrolyzed collagen or a derivative thereof having a molecular weight in the range of 500 to 5000 Anti-aging skin external preparation.   Component (A) A synthetic peptide composed of 3 to 8 amino acids or a derivative thereof, and component (B) hydrolyzed collagen or a derivative thereof having a molecular weight in the range of 500 to 5000 Anti-aging cosmetics.   2. The anti-aging skin external preparation according to claim 1, which promotes collagen production. 3. The anti-aging cosmetic according to claim 2, which promotes collagen production.