WO2020032460A1 - Skin care cosmetic composition comprising onion extract - Google Patents

Skin care cosmetic composition comprising onion extract Download PDF

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Publication number
WO2020032460A1
WO2020032460A1 PCT/KR2019/009472 KR2019009472W WO2020032460A1 WO 2020032460 A1 WO2020032460 A1 WO 2020032460A1 KR 2019009472 W KR2019009472 W KR 2019009472W WO 2020032460 A1 WO2020032460 A1 WO 2020032460A1
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WIPO (PCT)
Prior art keywords
onion
extract
weight
parts
skin
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PCT/KR2019/009472
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French (fr)
Korean (ko)
Inventor
안수연
Original Assignee
안수연
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Publication of WO2020032460A1 publication Critical patent/WO2020032460A1/en

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9794Liliopsida [monocotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/42Amides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60Sugars; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60Sugars; Derivatives thereof
    • A61K8/602Glycosides, e.g. rutin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64Proteins; Peptides; Derivatives or degradation products thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin

Definitions

  • the present invention relates to a skin care cosmetic composition comprising an onion extract, and more particularly, by preparing a cosmetic composition including an onion extract, has a regenerating effect of the skin and has a calming effect of acne, dermatitis, rashes and scalp or It relates to a skin care cosmetic composition comprising an onion extract having a sedative effect on skin itching and redness.
  • skin plays a primary role in preventing metabolism from various external factors that impair homeostasis through basic metabolic processes.
  • the skin is located at the outermost part of the body, and plays various roles such as protection through physical, chemical and biological barrier functions, thermoregulation, sensation, secretion and excretion, absorption, storage and regeneration.
  • they are most susceptible to damage when constant external stress is applied.
  • the main causes of such external stress are ultraviolet exposure, exhaust gas, yellow dust, environmental pollutants, heavy metals, temperature changes, and microorganisms, and these are mainly reactive oxygen species through oxidative stress. And ROS), which disrupts the antioxidant defenses, causing cell damage and death.
  • the natural substances have a low effect, or even if effective, may cause redness and inflammation, which may cause side effects on the skin, and problems of color and smell of cosmetic formulations.
  • the present inventors have studied to search for substances that have a soothing effect on the scalp or skin by improving the elasticity of the skin, and by preparing a cosmetic composition including onion extract, etc., to enhance the elasticity of the skin and to the scalp or skin It was confirmed that there is a soothing effect on the present invention was completed.
  • the present invention by producing a cosmetic composition comprising an onion extract, the skin containing the onion extract that has a regenerating effect of the skin and has a soothing effect on acne, dermatitis prevention, rash and sedation and redness of the scalp or skin It is to provide a care cosmetic composition.
  • the present invention can prevent hair loss due to the soothing effect on the scalp, and removes the dead skin and pores on the skin as well as make-up, minimizes skin troubles and irritation and can moisturize and smooth dry and dry skin
  • a skin care cosmetic composition comprising an onion extract.
  • the present invention provides a skin care cosmetic composition comprising an onion extract that can soothe irritation from the external environment to have healthy and beautiful skin and hair due to the natural regeneration, protection, immunity, and purification functions of the skin. have.
  • Skin care cosmetic composition comprising an onion extract according to the present invention includes an onion extract, copper tripeptide-1, centella extract, black soybean extract, panthenol and rutin.
  • the composition is 50 to 100 parts by weight of onion extract, copper tripeptide-1 (copper tripeptide-1) 5 to 15 parts by weight, centella extract 10 to 20 parts by weight, black soybean extract 10 to 20 parts by weight, panthenol 5 to 15 parts by weight And it may be included in the weight ratio of 3 to 8 parts by weight of the routine.
  • the composition further comprises a fermented black ginseng extract
  • the fermented black ginseng extract may be included in a weight ratio of 10 to 20 parts by weight based on 100 parts by weight of the onion extract.
  • the onion extract the onion was collected and washed for 1 to 5 minutes with purified water in which sodium hydrogen carbonate (NaHCO 3 ) having a concentration range of 1 to 3 (w / w)% and a temperature of 33 to 37 °C dissolved in onions Remove the foreign matter adhered to, the onion peel is separated into onion flesh and onion peel, and the onion flesh is dried in a dryer, the drying of the onion flesh is 20 to 25 °C temperature and 33 to 40% humidity Drying for 3 to 7 hours in a drier maintained with, the dried onion flesh mixed with purified water and heated to produce the onion flesh extract, the onion flesh extract is purified water with respect to 100 parts by weight of the dried onion flesh After mixing 500 to 1000 parts by weight to prepare the onion flesh extract by heating for 5 to 15 hours at a temperature of 95 to 105 °C, and dried the onion peel, Drying of the onion peel is dried for 3 to 7 hours in a dryer maintained at 30 to 35 °C and humidity 35 to 45%, the dried onion skin is mixed with purified water and heated
  • the amino acid sequence of copper tripeptide-1 may be coupled to copper (Cu) with an amino acid sequence of Gly-His-Lys (G-H-K).
  • composition further comprises a pineapple extract
  • the pineapple extract based on 100 parts by weight of the onion extract may be included in a weight ratio of 5 to 15 parts by weight.
  • the present invention by producing a cosmetic composition, including the onion extract, has a regenerating effect of the skin and has a soothing effect of acne, dermatitis prevention, rash and sedation effect on the itching and redness of the scalp or skin.
  • the present invention can prevent hair loss due to the soothing effect on the scalp, and removes the dead skin and pores on the skin as well as make-up, minimizes skin troubles and irritation and can moisturize and smooth dry and dry skin have.
  • the present invention soothes the irritation received from the external environment and can have healthy and beautiful skin and hair due to the natural regeneration, protection, immunity, and purification functions of the skin.
  • Skin care cosmetic composition comprising an onion extract according to the present invention includes onion extract, copper tripeptide-1 (Copper tripeptide-1), centella extract, black soybean extract, panthenol and rutin, the composition is 50 to 100 onion extract Parts by weight, 5 to 15 parts by weight of copper tripeptide-1, 10 to 20 parts by weight of Centella extract, 10 to 20 parts by weight of black bean extract, 5 to 15 parts by weight of panthenol and 3 to 8 parts by weight of rutin It can be included as a ratio.
  • onion extract copper tripeptide-1 (Copper tripeptide-1), centella extract, black soybean extract, panthenol and rutin
  • the composition is 50 to 100 onion extract Parts by weight, 5 to 15 parts by weight of copper tripeptide-1, 10 to 20 parts by weight of Centella extract, 10 to 20 parts by weight of black bean extract, 5 to 15 parts by weight of panthenol and 3 to 8 parts by weight of rutin It can be included as a ratio.
  • the skin care cosmetic composition comprising an onion extract according to the present invention may further comprise a fermented black ginseng extract or pineapple extract in addition to the composition, the fermented black ginseng extract is 10 to 20 parts by weight based on 100 parts by weight of the onion extract It is included in the weight ratio, pineapple extract may be included in the weight ratio of 5 to 15 parts by weight.
  • the onion extract is prepared by extracting the useful components of the onion, the onion (Allium cepa) is a perennial plant belonging to the family Liliaceae, it is used as food, spices, and medicinal herbs with a unique taste and aroma with a long history of cultivation have.
  • 100g of onion contains 90g of water, about 72g of carbohydrate, 11g of protein, 10 ⁇ 20mg of vitamin C, calcium, phosphorus, iron, etc.
  • Onion skin contains 504% of sugar, 2924% of fiber, 148% of fat, 499% of ash. It is contained.
  • onions are known for their antioxidant, hypolipidemic, antihypertensive, anti-inflammatory, antibacterial, anti-tumor and hypoglycemic effects.
  • the main biologically active substances contained in onions include organic sulfur compounds and flavonoid compounds.
  • onions contain quercetin, which exhibits antioxidant activity, much higher than other vegetables and fruits.
  • Quercetin is a plant-derived flavonoid-based phenolic compound that is not only a powerful antioxidant but also has anti-arteriosclerosis, antimicrobial activity, cholesterol lowering, anticancer, antiviral and anti-allergic activity, with little toxicity. It is known. Therefore, ingesting foods high in quercetin is effective in improving blood circulation, lowering blood pressure and diabetes, weight loss, diet, immune function, inhibiting DNA damage, and inhibiting lipid peroxidation of red blood cell membranes.
  • the onion extract may be prepared by the following method.
  • the onion was collected by 1 to 5 minutes with purified water in which sodium hydrogen carbonate (NaHCO 3 ) having a concentration range of 1 to 3 (w / w)% and a temperature of 33 to 37 ° C was dissolved. While washing to remove foreign substances attached to the onion, the onion peel can be separated into onion flesh and onion peel.
  • NaHCO 3 sodium hydrogen carbonate
  • the onion pulp is dried in a dryer, and the drying of the onion pulp is performed in a dryer in which a constant temperature and humidity are maintained to prevent chlorophyll of the onion pulp and the inherent aroma of onion pulp when the sunlight is dried.
  • the onion flesh may be dried for 3 to 7 hours in a dryer maintained at a temperature of 20 to 25 °C and humidity 33 to 40%.
  • the dried onion pulp may be mixed with purified water and then heated to prepare the onion pulp extract.
  • the onion flesh extract may be prepared by mixing 500 to 1000 parts by weight of purified water with respect to 100 parts by weight of the dried onion flesh and then heated for 5 to 15 hours at a temperature of 95 to 105 °C.
  • the onion skin may be dried to remove moisture contained in the onion skin, and the onion skin may be dried for 3 to 7 hours in a dryer maintained at 30 to 35 ° C. and a humidity of 35 to 45%.
  • the present invention by drying the onion peel under the above conditions, by gradually evaporating the moisture contained in the onion peel, it is possible to more easily extract the inherent flavor and useful components of the onion peel, The destruction of the cell structure of the onion peel facilitates the penetration of air and promotes fermentation, so that the useful components of the onion peel can be thickened.
  • the dried onion peel may be mixed with purified water and then heated to prepare the onion peel extract.
  • the onion peel extract may be mixed with 200 to 400 parts by weight of purified water based on 100 parts by weight of the dried onion peel. After immersing for 1 to 3 hours at a temperature of 60 to 70 °C, the purified water immersed in the onion peel is put into a heater, the purified water immersed in onion peel immersed in the heater inside the temperature and pressure vessel of 110 to 120 °C
  • the onion peel extract may be prepared by heating for 3 to 5 hours in a pressure range of 2.5 to 3.5 kgf / cm 2 .
  • the present invention can be extracted by immersing the onion peel in purified water as described above, thereby weakening the plant wall of the onion peel to increase the extraction efficiency.
  • an onion extract may be prepared by mixing the onion flesh extract and the onion peel extract, wherein the onion extract may be prepared by mixing the onion flesh extract and the onion peel extract in a weight ratio of 7: 3 to 6: 4. Can be.
  • the onion extract may be aged by storing for 1 to 5 hours at a temperature of 3 to 7 ° C., and the onion extract may be uniformly mixed and the flavor may be enhanced by aging the onion extract under the above conditions.
  • the copper tripeptide-1 (copper tripeptide-1) is a copper (copper) complex of tripeptide-1, and may be used for the purpose of wrinkle improvement, skin conditioning agent, anti-inflammatory, and the like.
  • the copper tripeptide-1 improves wound healing ability, enhances immune cell function, and has antioxidant and anti-inflammatory effects. It also promotes collagen synthesis and strengthens blood vessels in skin tissue. As a synthesized peptide, it is used for damage repair and anti-aging components. Aging prevention and firming and anti-wrinkle effect of the copper tripeptide-1 has been confirmed through research through scientific experiments.
  • the amino acid sequence of the copper tripeptide-1 is a form in which a glycopetide-based peptide is coordinated with a copper ion, starting with glycine as an amino terminal group, and amino acids to copper (Cu).
  • the sequence can be linked to Gly-His-Lys (GHK).
  • the copper tripeptide-1 may be prepared using a solid phase peptide synthesis method synthesized using a solid polymer retarder, and the copper tripeptide-1 is prepared using an automatic peptide synthesizer known in the art. Or it can be prepared directly, the synthesis method of the copper tripeptide-1 is a technique known in the art, so a detailed description thereof will be omitted.
  • centella extract increases blood circulation and promotes skin elasticity by promoting collagen synthesis.
  • centella extract soothing red skin and anti-inflammatory, soothing excellent acne skin.
  • the black soybean extract contains a polyphenol component to protect the skin and scalp from harmful oxygen, and the panthenol promotes cell division and helps the formation of epithelial cells, thereby helping to regenerate the skin, and the routine strengthens capillaries It is effective.
  • the fermented black ginseng extract may be prepared using fermented black ginseng prepared by the following method.
  • the fresh ginseng can be classified and selected according to the size, it is possible to use a variety of excellent ginseng, for example, it is preferable to use a ginseng 6 years old ginseng and a regular ginseng.
  • the washed ginseng may be immersed in the juice and browning inhibitor, the juice and browning inhibitor may be mixed in a weight ratio of 1: 1, the browning inhibitor is a vitamin C and salt solution of 1: 1 It can be mixed in weight ratio.
  • the grape juice is good for preventing blood clots and preventing adult diseases such as hypertension, arteriosclerosis and heart disease, and may help improve memory.
  • the salt solution used as the browning inhibitor may be a salt solution having a concentration of 0.6 to 0.6% by weight. After immersing in a weight ratio of 80 to 120 parts by weight of the grape juice and browning inhibitor with respect to 100 parts by weight of the washed ginseng may be carried out by maintaining for 30 to 60 minutes.
  • the ginseng can be steamed by taking out the ginseng immersed in the grape juice and browning inhibitor.
  • Steaming of the ginseng may be carried out by steaming the ginseng penetrated the components of the grape juice and browning inhibitor for 30 minutes to 100 minutes with steam at a temperature of 100 to 110 °C, steaming of the ginseng is carried out below the lower limit If there is a problem that the sufficient steaming is not made, if it is performed beyond the above upper limit range, the difference in the effect of the increase in the steaming time may be insignificant.
  • the dried ginseng may be washed with one or more acids of acetic acid or citric acid.
  • Drying of the steamed ginseng may be performed for 3 to 5 days at a temperature of 30 to 35 °C, to achieve a constant temperature, the dried steamed ginseng may be used for mechanical drying using a dryer.
  • the dried ginseng is washed with any one or more acids of acetic acid or citric acid, thereby improving the flavor, color, cracking and whitening incidence of black ginseng prepared through a later fermentation process.
  • the washed ginseng may be prepared rice straw absorbed moisture.
  • the straw is absorbed moisture can be prepared by fermenting ginseng by heating the black ginseng, the straw can be used straw prepared by the following method.
  • rice straw grown in an organic manner may be washed in purified water to remove foreign matters of the rice straw and cut into a predetermined length (eg, length of 5 to 10 cm).
  • the cut rice straw may be wet sterilized, and the germinated rice straw may be wet sterilized to kill various germs such as bacteria or mold remaining in the rice straw, and later fermented ginseng using the rice straw. It can prevent the growth of various bacteria such as bacteria and fungi that can be produced when the process.
  • Wet sterilization treatment of the rice straw in the present invention is carried out by using an autoclave, it can be carried out by supplying steam of 130 to 135 °C temperature to the rice straw for 30 to 60 minutes.
  • the wet sterilized rice straw may be sprayed with fermentation bacteria and culture medium which may promote fermentation or ripening of rice straw. That is, in general, when the rice straw is sufficiently immersed in water, fermentation of the straw containing water proceeds, and during the fermentation of the rice straw, Bacillus bacteria and the like may be multiplied, and the straw may be fermented. And by spraying the culture solution, it is possible to promote the fermentation of the rice straw, the fermentation of black ginseng by the heat of fermentation of the rice straw.
  • the culture medium is peptone, malt extract (Malt extract), sodium citrate (Sodium citrate), Potassium phosphate dibasic (Potassium phosphate dibasic), glucose (Glucose) and distilled water
  • the culture medium is 15 to 25 parts by weight of peptone, 5 to 15 parts by weight of malt extract, 0.5 to 1.5 parts by weight of sodium citrate, potassium diphosphate 0.1 to 0.3 parts by weight, 1 to 3 parts by weight of glucose and 100 to 200 parts by weight of distilled water
  • the Bacillus leachate and the culture medium are 20 to 40 parts by weight of Bacillus leachate and 500 to 1000 parts by weight of the culture solution, respectively. It can be mixed in proportions and sprayed on rice straw.
  • the peptone is a nitrogen source for supplying protein, and supplies the protein necessary for the growth of microorganisms
  • the malt extract contains various minerals, vitamin B groups, and amino acids, which may help the growth of microorganisms
  • the sodium citrate Silver is a mineral that maintains the optimized state for the growth of microorganisms by adjusting the pH of the culture medium, it can provide nutrition, and the glucose can function as an important component that fermentation bacteria metabolize sugar to produce organic acids.
  • Bacillus subtilis used as fermentation bacteria in the present invention can be obtained by the following method.
  • cleansed rice straw is placed in a container containing water, and boiled and sterilized for 30 to 60 minutes at a temperature of 110 to 115 ° C. to remove germs remaining in the rice straw.
  • the present invention can sterilize mold or other various bacteria by boiling for 30 to 60 minutes at a temperature of 110 to 115 °C as described above, because the subtilis bacterium is sterilized only after a long time at a temperature of 120 °C or more so as not to die Rice straw can be boiled and sterilized for 30 to 60 minutes at a temperature of 115 ° C.
  • Bacillus subtilis in which the rice straw is immersed at a temperature of 60 to 70 °C for 5 to 10 hours it is possible to propagate Bacillus subtilis contained in the Bacillus subtilis.
  • the present invention maintains the Bacillus subtilis leachate at a temperature of 60 to 70 °C so that Bacillus subtilis is suitable for propagation as described above, and the nutrients required when the Bacillus microbial growth is to be supplied from rice straw immersed in Bacillus subtilis leachate Can multiply.
  • Bacillus subtilis can contain the Bacillus subtilis can be prepared.
  • the rice straw sprayed with the Bacillus subtilis and the culture solution and the fresh ginseng may be mixed and then maintained at a constant temperature and humidity to ferment into black ginseng.
  • the fermentation is mixed with rice straw sprayed with the Bacillus subtilis and culture medium, ginseng 200 to 400 parts by weight and 10 to 30 parts by weight of fresh ginseng, respectively, the temperature of 65 to 70 °C and humidity of 60 to 65%
  • ginseng 200 to 400 parts by weight and 10 to 30 parts by weight of fresh ginseng, respectively, the temperature of 65 to 70 °C and humidity of 60 to 65%
  • the fermented black ginseng may be dried to prepare fermented black ginseng.
  • the fermented black ginseng is isolated from the fermented black ginseng and cold-dried for 20 to 40 hours at a temperature of 4 to 6 °C, and is contained in the black ginseng by maintaining for 5 to 10 days at a temperature of 60 to 65 °C Drying may be such that the water content is 15 to 20% by weight.
  • the fermented black ginseng extract by mixing at a weight ratio of 1500 to 200 parts by weight of water with respect to 100 parts by weight of fermented black ginseng for 1 to 3 hours at a temperature of 115 to 120 °C and a pressure of 3 to 4 kgf / cm 2 , Can be prepared.
  • the pineapple extract may be used pineapple extract prepared by the following manufacturing method.
  • the pineapple may be prepared and washed to remove foreign substances.
  • the pineapple may be washed by using purified water in which sodium hydrogen carbonate (NaHCO 3 ) is dissolved, and the pineapple remains on the surface of the pineapple by washing the surface of the pineapple using purified water in which sodium hydrogen carbonate is dissolved. It can improve the cleaning efficiency of pesticides, heavy metals and mold removal.
  • NaHCO 3 sodium hydrogen carbonate
  • the sodium hydrogen carbonate (NaHCO 3 ) is also used as a food additive, there is no toxicity and has a function of penetration, diffusion, expansion, etc., to clean the surface of the pineapple, the sodium hydrogen carbonate is 2 to 4 (w / w)% concentration range, it is preferred to wash for 1 to 5 minutes at a temperature of 20 to 30 °C.
  • the washed pineapple can be ground.
  • Grinding of the pineapple may be used by grinding the pineapple to a diameter of 0.5 to 2cm using a grinder or a blender in order to extract the active ingredient from the pineapple within a short time.
  • the pineapple can be steamed.
  • the steaming of the pineapple is to steam the crushed pineapple to steam with steam.
  • a first steaming step and a second steaming step that is, two steps of steaming, may be performed.
  • the first steaming step is heating the ground pineapple with steam at a temperature of 60 to 70 ° C. for 10 to 30 minutes
  • the second steaming step is heating the pineapple. Heating for 1 to 3 hours with steam at a temperature of 80 to 90 ° C.
  • the surface and the outside of the pineapple may be difficult to uniformly steam by water vapor, a temperature of more than 70 °C or If it is performed for more than 30 minutes, the temperature of the surface and the inside of the pineapple may be uniformly preheated so that no further increase in effect may appear.
  • the pineapple when the second steaming step is performed at a temperature of less than 80 ° C or less than 1 hour, the pineapple is not sufficiently steamed, and thus it is difficult to prepare the extract in a short time in a subsequent process, and the temperature of more than 90 ° C or 3 hours. If it is performed in excess, the active ingredient of the pineapple may be volatilized or the physical properties of the pineapple may be weakened.
  • the pineapple may be dried.
  • the drying of the pineapple may be performed for 50 to 200 minutes at the steamed pineapple at a temperature of 65 to 75 °C, if the drying of the pineapple is performed at a temperature below 65 °C or less than 50 minutes the steamed pineapple Problems may be difficult to sufficiently remove the residual water in the case, when the temperature is more than 75 °C or more than 200 minutes may not be removed any further residual moisture or the physical properties of the pineapple may occur.
  • the pineapple extract may be prepared by extracting the dried pineapple.
  • Extraction of the dried pineapple may use a known extraction method such as solvent extraction, hot water extraction or supercritical extraction, for example, the preparation of the pineapple extract (a) 70% (v) in 1000 ⁇ 1200g dried pineapple / v) First extraction with ethanol aqueous solution 10-12L for 3-4 hours at 85 to 90 °C, then 70% (v / v) secondary extraction for 2 to 3 hours at 85-90 °C with 4-6L of ethanol aqueous solution To complete the step, preparing an extract until the 1000 to 1200ml in a vacuum rotary evaporator; (b) adding water to the extract 2 to 3 times, centrifuging at 14,000 to 15,000 rpm for 20 to 30 minutes to completely remove polymer fibers and solids, and then collecting the collected supernatant twice with 1.2 to 1.5 times chloroform. Extracting; And (c) removing the chloroform layer and extracting the aqueous layer three times with 1.2 to 1.5 times ethyl acetate to prepare a pineapple extract.
  • Skin care cosmetics by mixing 80 parts by weight of onion extract, 10 parts by weight of copper tripeptide-1, 15 parts by weight of centella extract, 15 parts by weight of black bean extract, 10 parts by weight of panthenol and 5 parts by weight of rutin The composition was prepared.
  • Example 2 Using the same composition as in Example 1 to prepare a skin care cosmetic composition, in Example 2 to prepare a cosmetic composition by including 15 parts by weight of fermented black ginseng extract with respect to 100 parts by weight of the onion extract.
  • a skin care cosmetic composition was prepared using the same composition as in Example 1, but in Example 3, 10 parts by weight of pineapple extract was further included with respect to 100 parts by weight of the onion extract to prepare a cosmetic composition.
  • a skin care cosmetic composition was prepared using the same composition as in Example 1, but the onion extract was not included in the comparative example.
  • the degree of absorption was applied to the hair and hands 20 subjects of cosmetics 3g, the sensory evaluation was performed for the degree of absorption, the results are shown in Table 4 below.
  • the score and evaluation criteria for the sensory evaluation was used a five-point scoring method, the score and evaluation criteria are as shown in Table 3 below.
  • Example 2 Example 3 Comparative example Skin absorption 4.3 4.6 4.4 3.1 Hair absorption 4.5 4.5 4.3 3.3
  • Skin care cosmetic composition comprising an onion extract according to the present invention can be used as a therapeutic agent for preventing acne, dermatitis and cosmetics to relieve itching and redness of the scalp or skin.

Abstract

The present invention relates to a skin care cosmetic composition comprising an onion extract. A skin care cosmetic composition comprising an onion extract, according to the present invention, comprises an onion extract, copper tripeptide-1, a centella asiatica extract, a black bean extract, panthenol and rutin. Therefore, the present invention allows a cosmetic composition including an onion extract to be prepared so as to have a skin regeneration effect, an acne and dermatitis prevention effect and a pimple calming effect, and an effect of calming itching and redness of the scalp or the skin.

Description

양파 추출물을 포함하는 피부관리 화장료 조성물Skin care cosmetic composition comprising onion extract
본 발명은 양파 추출물을 포함하는 피부관리 화장료 조성물에 관한 것으로서, 더욱 상세하게는 양파 추출물을 포함하여 화장료 조성물을 제조함으로써, 피부의 재생 효과가 있고 여드름, 피부염 예방, 뾰루지의 진정효과가 있으며 두피 또는 피부의 가려움 및 붉어짐에 대한 진정효과가 있는 양파 추출물을 포함하는 피부관리 화장료 조성물에 관한 것이다.The present invention relates to a skin care cosmetic composition comprising an onion extract, and more particularly, by preparing a cosmetic composition including an onion extract, has a regenerating effect of the skin and has a calming effect of acne, dermatitis, rashes and scalp or It relates to a skin care cosmetic composition comprising an onion extract having a sedative effect on skin itching and redness.
현대사회는 배기가스, 유해 화학물질, 오존층의 파괴 등으로 자외선, 수질오염 등에 의한 활성산소가 대량으로 발생하고 있고, 이러한 활성산소는 인체에 침투하여 여러 가지 부작용을 일으키며, 특히 색소변화, 피부노화, 탈모 등의 주요원인으로 알려지고 있다.In modern society, active oxygen is generated in large quantities by ultraviolet rays, water pollution, etc. due to destruction of exhaust gas, harmful chemicals, ozone layer, etc., and these active oxygen penetrate into human body and cause various side effects, especially pigment change and skin aging. It is known as a major cause of hair loss.
또한, 근래에는 과중한 사회적, 업무적 스트레스를 해소하기 위하여 등산, 캠핑, 골프 등과 같은 야외에서의 레저활동이 증가하고 있는데, 이러한 야회에서의 레저활동 중에는 신체 피부가 상기한 오염원 등에 더욱 쉽게 직접적으로 노출되기 때문에 피부훼손 및 피부노화를 피할 수 없는 실정이어서 야외 레저활동을 보다 적극적이고 쾌적하게 즐기고자 하는 추세에 부정적인 영향을 미치고 있다.In recent years, outdoor leisure activities such as hiking, camping, and golf have been increasing in order to relieve excessive social and work stress. During leisure activities, the skin of the body is more easily directly exposed to the pollutants. Due to the fact that skin damage and skin aging cannot be avoided, it has a negative effect on the trend of more active and pleasant enjoyment of outdoor leisure activities.
일반적으로 피부는 기본적인 신진대사 과정을 통하여 우리 몸의 항상성을 저해하는 다양한 외부 요인으로부터 위해를 막아주는 일차적인 기능을 담당하고 있다. 즉, 피부는 신체 가장 바깥쪽에 위치함으로써 물리적, 화학적, 생물학적 장벽기능을 통한 보호작용, 체온조절작용, 감각작용, 분비 및 배설작용, 흡수작용, 저장작용, 재생작용 등의 다양한 역할을 수행하고 있지만, 지속적인 외부 스트레스가 가해지는 경우 가장 손상을 받기 쉽다.In general, skin plays a primary role in preventing metabolism from various external factors that impair homeostasis through basic metabolic processes. In other words, the skin is located at the outermost part of the body, and plays various roles such as protection through physical, chemical and biological barrier functions, thermoregulation, sensation, secretion and excretion, absorption, storage and regeneration. However, they are most susceptible to damage when constant external stress is applied.
이러한 외부 스트레스의 주요 원인으로는 자외선 노출, 배기가스, 황사, 환경오염물, 중금속, 온도변화, 미생물을 대표적인 예로 들 수 있으며, 이들은 주로 산화적 스트레스(oxidative stress)를 통하여 활성산소종(reactive oxygen species, ROS)을 생성함으로써, 항산화 방어체계를 붕괴시켜 세포 손상 및 사멸을 야기하게 된다.The main causes of such external stress are ultraviolet exposure, exhaust gas, yellow dust, environmental pollutants, heavy metals, temperature changes, and microorganisms, and these are mainly reactive oxygen species through oxidative stress. And ROS), which disrupts the antioxidant defenses, causing cell damage and death.
아울러, 최근에는 천연물 소재의 친환경적 피부진정용 화장료 소재의 개발이 각광을 받고 있다. 예를 들어, 아마인 추출물과 엔트로모르파 컴프레사 추출물(국내등록특허 제10-0253425호), 목련, 산다화, 연꽃, 봉선화 및 진달래 추출물(국내등록특허 제10-0898308호), 석류, 토마토 및 포도발효 추출물(국내공개특허 제2007-0008150호) 등이 알려져 있다.In addition, in recent years, the development of eco-friendly skin soothing cosmetic material of the natural material has been in the spotlight. For example, linseed extract and entromorpha compressor extract (National Patent No. 10-0253425), magnolia, sanda, lotus, balsam and Rhododendron extract (National Patent No. 10-0898308), pomegranate, tomato And grape fermented extract (Korean Patent Publication No. 2007-0008150) and the like are known.
그러나, 상기 천연물질들은 그 효과가 낮거나, 효과가 있더라도 발적, 염증을 유발시켜 피부에 대한 부작용을 일으킬 수 있는 문제와, 화장품 제형의 색상과 냄새의 문제 등을 가지고 있다.However, the natural substances have a low effect, or even if effective, may cause redness and inflammation, which may cause side effects on the skin, and problems of color and smell of cosmetic formulations.
따라서, 피부 깊숙히 유효 성분을 전달할 수 있으면서 피부자극 완화 및 피부진정 효과가 우수한, 바람직한 화장품 제형을 나타내는 기술이 필요하다.Therefore, there is a need for a technology that represents a desirable cosmetic formulation that can deliver the active ingredient deep into the skin and which is superior in skin irritation and skin soothing effects.
이에, 본 발명자는 피부의 탄력을 증진시키고 두피 또는 피부에 대한 진정 효과가 있는 물질을 탐색하고자 연구한 결과, 양파 추출물 등을 포함하여 화장료 조성물을 제조함으로써, 피부의 탄력을 증진시키고 두피 또는 피부에 대한 진정 효과가 있음을 확인하고 본 발명을 완성하였다.Accordingly, the present inventors have studied to search for substances that have a soothing effect on the scalp or skin by improving the elasticity of the skin, and by preparing a cosmetic composition including onion extract, etc., to enhance the elasticity of the skin and to the scalp or skin It was confirmed that there is a soothing effect on the present invention was completed.
본 발명은 양파 추출물을 포함하여 화장료 조성물을 제조함으로써, 피부의 재생 효과가 있고 여드름, 피부염 예방, 뾰루지의 진정효과가 있으며 두피 또는 피부의 가려움 및 붉어짐에 대한 진정효과가 있는 양파 추출물을 포함하는 피부관리 화장료 조성물을 제공하는데 있다.The present invention by producing a cosmetic composition comprising an onion extract, the skin containing the onion extract that has a regenerating effect of the skin and has a soothing effect on acne, dermatitis prevention, rash and sedation and redness of the scalp or skin It is to provide a care cosmetic composition.
또한, 본 발명은 두피에 대한 진정 효과로 인해 탈모도 방지할 수 있고 메이크업은 물론 피부 상의 각질과 모공 속의 노폐물을 깨끗하게 제거해주고 피부트러블과 피부자극을 최소화하며 메마르고 건조한 피부를 촉촉하고 매끄럽게 가꾸어줄 수 있는 양파 추출물을 포함하는 피부관리 화장료 조성물을 제공하는데 있다.In addition, the present invention can prevent hair loss due to the soothing effect on the scalp, and removes the dead skin and pores on the skin as well as make-up, minimizes skin troubles and irritation and can moisturize and smooth dry and dry skin To provide a skin care cosmetic composition comprising an onion extract.
또한, 본 발명은 외부 환경으로부터 받은 자극을 진정시켜 주어 피부 본연의 재생, 보호, 면역, 정화 기능으로 인해 건강하고 아름다운 피부와 모발을 가지게 할 수 있는 양파 추출물을 포함하는 피부관리 화장료 조성물을 제공하는데 있다.In addition, the present invention provides a skin care cosmetic composition comprising an onion extract that can soothe irritation from the external environment to have healthy and beautiful skin and hair due to the natural regeneration, protection, immunity, and purification functions of the skin. have.
본 발명이 해결하고자 하는 다양한 과제들은 이상에서 언급한 과제들에 제한되지 않으며, 언급되지 않은 또 다른 과제들은 아래의 기재로부터 당업자에게 명확하게 이해될 수 있을 것이다.The various problems to be solved by the present invention are not limited to the above-mentioned problems, and other problems not mentioned will be clearly understood by those skilled in the art from the following description.
본 발명에 따른 양파 추출물을 포함하는 피부관리 화장료 조성물은 양파 추출물, 카퍼 트리펩타이드-1(copper tripeptide-1), 병풀 추출물, 검정콩 추출물, 판테놀 및 루틴을 포함한다.Skin care cosmetic composition comprising an onion extract according to the present invention includes an onion extract, copper tripeptide-1, centella extract, black soybean extract, panthenol and rutin.
상기 조성물은 양파 추출물 50 내지 100 중량부, 카퍼 트리펩타이드-1(copper tripeptide-1) 5 내지 15 중량부, 병풀 추출물 10 내지 20 중량부, 검정콩 추출물 10 내지 20 중량부, 판테놀 5 내지 15 중량부 및 루틴 3 내지 8 중량부의 중량 비율로 포함될 수 있다.The composition is 50 to 100 parts by weight of onion extract, copper tripeptide-1 (copper tripeptide-1) 5 to 15 parts by weight, centella extract 10 to 20 parts by weight, black soybean extract 10 to 20 parts by weight, panthenol 5 to 15 parts by weight And it may be included in the weight ratio of 3 to 8 parts by weight of the routine.
상기 조성물 이외에 발효흑삼 추출물을 더 포함하되, 상기 양파 추출물 100 중량부에 대해 상기 발효흑삼 추출물이 10 내지 20 중량부의 중량 비율로 포함될 수 있다.In addition to the composition further comprises a fermented black ginseng extract, the fermented black ginseng extract may be included in a weight ratio of 10 to 20 parts by weight based on 100 parts by weight of the onion extract.
상기 양파 추출물은, 양파를 채취하여 1 내지 3(w/w)% 농도 범위 및 33 내지 37℃의 온도를 가지는 탄산수소나트륨(NaHCO 3)이 용해된 정제수로 1 내지 5분 동안 세척하여 양파에 부착되어 있는 이물질을 제거하고, 상기 양파의 껍질을 분리하여 양파 과육 및 양파 껍질로 분리하고, 상기 양파 과육을 건조기에서 건조하되, 상기 양파 과육의 건조는 온도 20 내지 25℃ 및 습도 33 내지 40%로 유지되는 건조기에서 3 내지 7시간 동안 건조하며, 상기 건조된 양파 과육을 정제수와 혼합한 후 가열하여 상기 양파 과육 추출물을 제조하되, 상기 양파 과육 추출물은 상기 건조된 양파 과육 100 중량부에 대하여 정제수 500 내지 1000 중량부를 혼합한 후 95 내지 105℃의 온도에서 5 내지 15시간 동안 가열함으로써 상기 양파 과육 추출물을 제조하고, 상기 양파 껍질을 건조하되, 상기 양파 껍질의 건조는 30 내지 35℃ 및 습도 35 내지 45%로 유지되는 건조기에서 3 내지 7시간 동안 건조하며, 상기 건조된 양파 껍질을 정제수와 혼합한 후 가열하여 상기 양파 껍질 추출물을 제조하되, 상기 양파 껍질 추출물은 상기 건조된 양파 껍질 100 중량부에 대하여 정제수 200 내지 400 중량부를 혼합한 후 60 내지 70℃의 온도에서 1 내지 3시간 동안 침지시킨 후, 상기 양파 껍질이 침지된 정제수를 가열기에 투입하고, 상기 가열기에 투입된 양파 껍질이 침지된 정제수를 110 내지 120℃의 온도 및 압력용기 내부 압력 2.5 내지 3.5kgf/cm 2의 범위에서 3 내지 5시간 동안 가열함으로써 상기 양파 껍질 추출물을 제조하고, 상기 양파 과육 추출물 및 양파 껍질 추출물을 혼합함으로써 양파 추출물을 제조하되, 상기 양파 추출물은 양파 과육 추출물 및 양파 껍질 추출물을 7:3 내지 6:4의 중량 비율로 혼합하며, 상기 양파 추출물을 3 내지 7℃의 온도에서 1 내지 5시간 보관함으로써 숙성시켜 제조될 수 있다.The onion extract, the onion was collected and washed for 1 to 5 minutes with purified water in which sodium hydrogen carbonate (NaHCO 3 ) having a concentration range of 1 to 3 (w / w)% and a temperature of 33 to 37 ℃ dissolved in onions Remove the foreign matter adhered to, the onion peel is separated into onion flesh and onion peel, and the onion flesh is dried in a dryer, the drying of the onion flesh is 20 to 25 ℃ temperature and 33 to 40% humidity Drying for 3 to 7 hours in a drier maintained with, the dried onion flesh mixed with purified water and heated to produce the onion flesh extract, the onion flesh extract is purified water with respect to 100 parts by weight of the dried onion flesh After mixing 500 to 1000 parts by weight to prepare the onion flesh extract by heating for 5 to 15 hours at a temperature of 95 to 105 ℃, and dried the onion peel, Drying of the onion peel is dried for 3 to 7 hours in a dryer maintained at 30 to 35 ℃ and humidity 35 to 45%, the dried onion skin is mixed with purified water and heated to prepare the onion peel extract, The onion peel extract is mixed with 200 to 400 parts by weight of purified water with respect to 100 parts by weight of the dried onion peel and then immersed for 1 to 3 hours at a temperature of 60 to 70 ℃, the onion skin is immersed purified water in a heater To prepare the onion peel extract by heating for 3 to 5 hours at a temperature of 110 to 120 ℃ and the inside of the pressure of the vessel is immersed in the onion skin immersed in a temperature of 110 to 120 ℃ and 2.5 to 3.5kgf / cm 2 , Onion extract is prepared by mixing the onion flesh extract and onion peel extract, the onion extract is onion flesh extract and onion peel Extract 7: 3 to 6: mixed in a weight ratio of 4, and may be prepared by aging by storage 1 to 5 hours at a temperature of the onion extract 3 to 7 ℃.
상기 카퍼 트리펩타이드-1(copper tripeptide-1)의 아미노산 서열은 구리(Cu)에 아미노산 서열이 Gly-His-Lys(G-H-K)로 결합될 수 있다.The amino acid sequence of copper tripeptide-1 may be coupled to copper (Cu) with an amino acid sequence of Gly-His-Lys (G-H-K).
상기 조성물 이외에 파인애플 추출물을 더 포함하되, 상기 양파 추출물 100 중량부에 대해 상기 파인애플 추출물은 5 내지 15 중량부의 중량 비율로 포함될 수 있다.In addition to the composition further comprises a pineapple extract, the pineapple extract based on 100 parts by weight of the onion extract may be included in a weight ratio of 5 to 15 parts by weight.
기타 실시 예들의 구체적인 사항들은 상세한 설명에 포함되어 있다.Specific details of other embodiments are included in the detailed description.
본 발명은 양파 추출물을 포함하여 화장료 조성물을 제조함으로써, 피부의 재생 효과가 있고 여드름, 피부염 예방, 뾰루지의 진정효과가 있으며 두피 또는 피부의 가려움 및 붉어짐에 대한 진정효과가 있다.The present invention by producing a cosmetic composition, including the onion extract, has a regenerating effect of the skin and has a soothing effect of acne, dermatitis prevention, rash and sedation effect on the itching and redness of the scalp or skin.
또한, 본 발명은 두피에 대한 진정 효과로 인해 탈모도 방지할 수 있고 메이크업은 물론 피부 상의 각질과 모공 속의 노폐물을 깨끗하게 제거해주고 피부트러블과 피부자극을 최소화하며 메마르고 건조한 피부를 촉촉하고 매끄럽게 가꾸어줄 수 있다.In addition, the present invention can prevent hair loss due to the soothing effect on the scalp, and removes the dead skin and pores on the skin as well as make-up, minimizes skin troubles and irritation and can moisturize and smooth dry and dry skin have.
또한, 본 발명은 외부 환경으로부터 받은 자극을 진정시켜 주어 피부 본연의 재생, 보호, 면역, 정화 기능으로 인해 건강하고 아름다운 피부와 모발을 가지게 할 수 있다.In addition, the present invention soothes the irritation received from the external environment and can have healthy and beautiful skin and hair due to the natural regeneration, protection, immunity, and purification functions of the skin.
본 발명의 기술적 사상의 실시예는, 구체적으로 언급되지 않은 다양한 효과를 제공할 수 있다는 것이 충분히 이해될 수 있을 것이다.It will be fully understood that embodiments of the inventive concept may provide various effects not specifically mentioned.
본 발명의 이점 및 특징, 그리고 그것들을 달성하는 방법은 상세하게 후술되어 있는 실시예를 참조하면 명확해질 것이다. 그러나 본 발명은 여기서 설명되는 실시예들에 한정되지 않고 다른 형태로 구체화될 수도 있다. 오히려, 여기서 소개되는 실시예들은 개시된 내용이 철저하고 완전해질 수 있도록 그리고 당업자에게 본 발명의 사상이 충분히 전달될 수 있도록 하기 위해 제공되는 것이다.Advantages and features of the present invention and methods for achieving them will be apparent with reference to the embodiments described below in detail. However, the present invention is not limited to the embodiments described herein and may be embodied in other forms. Rather, the embodiments introduced herein are provided so that the disclosure may be made thorough and complete, and to fully convey the spirit of the invention to those skilled in the art.
본 출원에서 사용한 용어는 단지 특정한 실시예를 설명하기 위해 사용된 것으로, 본 발명을 한정하려는 의도가 아니다. 단수의 표현은 문맥상 명백하게 다르게 뜻하지 않는 한, 복수의 표현을 포함한다.The terminology used herein is for the purpose of describing particular example embodiments only and is not intended to be limiting of the present invention. Singular expressions include plural expressions unless the context clearly indicates otherwise.
다르게 정의되지 않는 한, 기술적이거나 과학적인 용어를 포함해서 여기서 사용되는 모든 용어들은 본 발명이 속하는 기술 분야에서 통상의 지식을 가진 자에 의해 일반적으로 이해되는 것과 동일한 의미가 있다. 일반적으로 사용되는 사전에 정의되어 있는 것과 같은 용어들은 관련 기술의 문맥상 가지는 의미와 일치하는 의미가 있는 것으로 해석되어야 하며, 본 출원에서 명백하게 정의하지 않는 한, 이상적이거나 과도하게 형식적인 의미로 해석되지 않는다.Unless defined otherwise, all terms used herein, including technical or scientific terms, have the same meaning as commonly understood by one of ordinary skill in the art. Terms such as those defined in the commonly used dictionaries should be construed as having meanings consistent with the meanings in the context of the related art and shall not be construed in ideal or excessively formal meanings unless expressly defined in this application. Do not.
이하, 본 발명에 따른 양파 추출물을 포함하는 피부관리 화장료 조성물에 대하여 더욱 상세하게 설명하기로 한다.Hereinafter, the skin care cosmetic composition comprising the onion extract according to the present invention will be described in more detail.
본 발명에 따른 양파 추출물을 포함하는 피부관리 화장료 조성물은 양파 추출물, 카퍼 트리펩타이드-1(copper tripeptide-1), 병풀 추출물, 검정콩 추출물, 판테놀 및 루틴을 포함하고, 상기 조성물은 양파 추출물 50 내지 100 중량부, 카퍼 트리펩타이드-1(copper tripeptide-1) 5 내지 15 중량부, 병풀 추출물 10 내지 20 중량부, 검정콩 추출물 10 내지 20 중량부, 판테놀 5 내지 15 중량부 및 루틴 3 내지 8 중량부의 중량 비율로 포함될 수 있다.Skin care cosmetic composition comprising an onion extract according to the present invention includes onion extract, copper tripeptide-1 (Copper tripeptide-1), centella extract, black soybean extract, panthenol and rutin, the composition is 50 to 100 onion extract Parts by weight, 5 to 15 parts by weight of copper tripeptide-1, 10 to 20 parts by weight of Centella extract, 10 to 20 parts by weight of black bean extract, 5 to 15 parts by weight of panthenol and 3 to 8 parts by weight of rutin It can be included as a ratio.
또한, 본 발명에 따른 양파 추출물을 포함하는 피부관리 화장료 조성물은 상기 조성물 이외에 발효흑삼 추출물 또는 파인애플 추출물을 더 포함할 수 있는데, 상기 양파 추출물 100 중량부에 대해 상기 발효흑삼 추출물은 10 내지 20 중량부의 중량 비율로 포함되고, 파인애플 추출물은 5 내지 15 중량부의 중량 비율로 포함될 수 있다.In addition, the skin care cosmetic composition comprising an onion extract according to the present invention may further comprise a fermented black ginseng extract or pineapple extract in addition to the composition, the fermented black ginseng extract is 10 to 20 parts by weight based on 100 parts by weight of the onion extract It is included in the weight ratio, pineapple extract may be included in the weight ratio of 5 to 15 parts by weight.
상기 양파 추출물은 양파의 유용성분을 추출하여 제조되는데, 상기 양파(Allium cepa)는 백합과에 속하는 다년생 식물로, 오랜 재배역사와 더불어 특유의 맛과 향을 적용한 식품, 향신료 및 약재 등으로 이용되고 있다. 양파 100g에는 수분 90g, 탄수화물 약 72g, 단백질 11g, 비타민 C 10 내지 20mg, 칼슘, 인, 철 등이 함유되어 있으며, 양파껍질에는 당질 504%, 섬유질 2924%, 지방 148%, 회분 499% 등이 함유되어 있다.The onion extract is prepared by extracting the useful components of the onion, the onion (Allium cepa) is a perennial plant belonging to the family Liliaceae, it is used as food, spices, and medicinal herbs with a unique taste and aroma with a long history of cultivation have. 100g of onion contains 90g of water, about 72g of carbohydrate, 11g of protein, 10 ~ 20mg of vitamin C, calcium, phosphorus, iron, etc. Onion skin contains 504% of sugar, 2924% of fiber, 148% of fat, 499% of ash. It is contained.
양파의 효능으로는 항산화, 혈액 지질 저하, 항고혈압, 항염증, 항균, 항종양, 혈당 저하 등이 알려져 있다. 양파 내에 함유된 주요 생리활성물질로는 유기 황화합물과 플라보노이드 화합물을 들 수 있으며, 특히 양파에는 항산화 작용을 나타내는 케르세틴(quercetin)이 다른 야채나 과일에 비해 매우 높게 함유되어 있다. 케르세틴은 식물유래 플라보노이드계(flavonoid)계의 페놀화합물로서, 강력한 항산화제(antioxidant)일 뿐만 아니라 항동맥 경화, 항균작용, 콜레스테롤 저하, 항암, 항바이러스 및 항알러지 활성을 지니고 있으면서 독성은 거의 나타나지 않는 것으로 알려져 있다. 따라서 케르세틴이 많이 함유되어 있는 식품을 섭취하면 혈액순환 개선, 혈압 강하와 당뇨, 체중감소 등의 다이어트, 면역기능 강화, DNA 손상억제효과 및 적혈구 막의 지질과산화 저해효과 등에 효과가 있다.Onions are known for their antioxidant, hypolipidemic, antihypertensive, anti-inflammatory, antibacterial, anti-tumor and hypoglycemic effects. The main biologically active substances contained in onions include organic sulfur compounds and flavonoid compounds. Especially, onions contain quercetin, which exhibits antioxidant activity, much higher than other vegetables and fruits. Quercetin is a plant-derived flavonoid-based phenolic compound that is not only a powerful antioxidant but also has anti-arteriosclerosis, antimicrobial activity, cholesterol lowering, anticancer, antiviral and anti-allergic activity, with little toxicity. It is known. Therefore, ingesting foods high in quercetin is effective in improving blood circulation, lowering blood pressure and diabetes, weight loss, diet, immune function, inhibiting DNA damage, and inhibiting lipid peroxidation of red blood cell membranes.
본 발명에서 상기 양파 추출물은 하기의 제조방법으로 제조될 수 있다.In the present invention, the onion extract may be prepared by the following method.
상기 양파 추출물을 제조하기 위하여, 먼저, 양파를 채취하여 1 내지 3(w/w)% 농도 범위 및 33 내지 37℃의 온도를 가지는 탄산수소나트륨(NaHCO 3)이 용해된 정제수로 1 내지 5분 동안 세척하여 양파에 부착되어 있는 이물질을 제거하고, 상기 양파의 껍질을 분리하여 양파 과육 및 양파 껍질로 분리할 수 있다.In order to prepare the onion extract, first, the onion was collected by 1 to 5 minutes with purified water in which sodium hydrogen carbonate (NaHCO 3 ) having a concentration range of 1 to 3 (w / w)% and a temperature of 33 to 37 ° C was dissolved. While washing to remove foreign substances attached to the onion, the onion peel can be separated into onion flesh and onion peel.
다음으로, 상기 양파 과육을 건조기에서 건조하되, 상기 양파 과육의 건조는 햇빛 건조시 상기 양파 과육의 엽록소가 파괴되고 양파 과육 고유의 향이 사라지는 것을 방지하기 위하여 일정한 온도 및 습도가 유지되는 건조기에서 수행될 수 있는데, 예를 들어, 상기 양파 과육의 건조는 온도 20 내지 25℃ 및 습도 33 내지 40%로 유지되는 건조기에서 3 내지 7시간 동안 건조할 수 있다.Next, the onion pulp is dried in a dryer, and the drying of the onion pulp is performed in a dryer in which a constant temperature and humidity are maintained to prevent chlorophyll of the onion pulp and the inherent aroma of onion pulp when the sunlight is dried. For example, the onion flesh may be dried for 3 to 7 hours in a dryer maintained at a temperature of 20 to 25 ℃ and humidity 33 to 40%.
그 다음으로, 상기 건조된 양파 과육을 정제수와 혼합한 후 가열하여 상기 양파 과육 추출물을 제조할 수 있다.Next, the dried onion pulp may be mixed with purified water and then heated to prepare the onion pulp extract.
상기 양파 과육 추출물은 상기 건조된 양파 과육 100 중량부에 대하여 정제수 500 내지 1000 중량부를 혼합한 후 95 내지 105℃의 온도에서 5 내지 15시간 동안 가열함으로써 상기 양파 과육 추출물을 제조할 수 있다.The onion flesh extract may be prepared by mixing 500 to 1000 parts by weight of purified water with respect to 100 parts by weight of the dried onion flesh and then heated for 5 to 15 hours at a temperature of 95 to 105 ℃.
이어서, 양파 껍질을 건조하여 상기 양파 껍질에 함유되어 있는 수분을 제거할 수 있고, 상기 양파 껍질의 건조는 30 내지 35℃ 및 습도 35 내지 45%로 유지되는 건조기에서 3 내지 7시간 동안 건조할 수 있는데, 본 발명은 상기와 같은 조건으로 양파 껍질을 건조함으로써, 상기 양파 껍질에 포함되어 있는 수분이 점진적으로 고르게 증발되도록 함으로써, 양파 껍질의 고유의 향과 유용성분을 보다 용이하게 추출시킬 수 있고, 양파 껍질의 세포조직의 파괴로 공기의 침투를 용이하게 하여 발효작용을 촉진함으로써 양파 껍질의 유용성분이 진하게 우러나도록 할 수 있다.Subsequently, the onion skin may be dried to remove moisture contained in the onion skin, and the onion skin may be dried for 3 to 7 hours in a dryer maintained at 30 to 35 ° C. and a humidity of 35 to 45%. There is, the present invention by drying the onion peel under the above conditions, by gradually evaporating the moisture contained in the onion peel, it is possible to more easily extract the inherent flavor and useful components of the onion peel, The destruction of the cell structure of the onion peel facilitates the penetration of air and promotes fermentation, so that the useful components of the onion peel can be thickened.
다음으로, 상기 건조된 양파 껍질을 정제수와 혼합한 후 가열하여 상기 양파 껍질 추출물을 제조할 수 있는데, 상기 양파 껍질 추출물은 상기 건조된 양파 껍질 100 중량부에 대하여 정제수 200 내지 400 중량부를 혼합한 후 60 내지 70℃의 온도에서 1 내지 3시간 동안 침지시킨 후, 상기 양파 껍질이 침지된 정제수를 가열기에 투입하고, 상기 가열기에 투입된 양파 껍질이 침지된 정제수를 110 내지 120℃의 온도 및 압력용기 내부 압력 2.5 내지 3.5kgf/cm 2의 범위에서 3 내지 5시간 동안 가열함으로써 상기 양파 껍질 추출물을 제조할 수 있다.Next, the dried onion peel may be mixed with purified water and then heated to prepare the onion peel extract. The onion peel extract may be mixed with 200 to 400 parts by weight of purified water based on 100 parts by weight of the dried onion peel. After immersing for 1 to 3 hours at a temperature of 60 to 70 ℃, the purified water immersed in the onion peel is put into a heater, the purified water immersed in onion peel immersed in the heater inside the temperature and pressure vessel of 110 to 120 ℃ The onion peel extract may be prepared by heating for 3 to 5 hours in a pressure range of 2.5 to 3.5 kgf / cm 2 .
본 발명은 상기와 같이 양파 껍질을 정제수에 침지시킨 후 추출함으로써, 양파 껍질의 식물벽을 약화시켜 추출 효율을 증대시킬 수 있다.The present invention can be extracted by immersing the onion peel in purified water as described above, thereby weakening the plant wall of the onion peel to increase the extraction efficiency.
그 다음으로, 상기 양파 과육 추출물 및 양파 껍질 추출물을 혼합함으로써 양파 추출물을 제조할 수 있는데, 상기 양파 추출물은 양파 과육 추출물 및 양파 껍질 추출물을 7:3 내지 6:4의 중량 비율로 혼합하여 제조될 수 있다.Next, an onion extract may be prepared by mixing the onion flesh extract and the onion peel extract, wherein the onion extract may be prepared by mixing the onion flesh extract and the onion peel extract in a weight ratio of 7: 3 to 6: 4. Can be.
이어서, 상기 양파 추출물을 3 내지 7℃의 온도에서 1 내지 5시간 보관함으로써 숙성시킬 수 있는데, 상기 양파 추출물을 상기와 같은 조건에서 숙성시킴으로써 상기 양파 추출물이 균일하게 혼합되고 향이 증진되게 할 수 있다.Subsequently, the onion extract may be aged by storing for 1 to 5 hours at a temperature of 3 to 7 ° C., and the onion extract may be uniformly mixed and the flavor may be enhanced by aging the onion extract under the above conditions.
상기 카퍼 트리펩타이드-1(copper tripeptide-1)는 트리펩타이드-1의 카퍼(Copper) 복합체로, 주름개선, 피부컨디셔닝제, 항염 등의 목적으로 사용될 수 있다.The copper tripeptide-1 (copper tripeptide-1) is a copper (copper) complex of tripeptide-1, and may be used for the purpose of wrinkle improvement, skin conditioning agent, anti-inflammatory, and the like.
즉, 상기 카퍼 트리펩타이드-1(copper tripeptide-1)는 상처 치유 능력을 향상시키고 면역세포기능을 높이며 항산화와 항염증효과 있다. 또한, 피부 조직 내에서 콜라겐 합성을 촉진하고 혈관을 강화한다. 합성된 펩타이드로서 손상회복과 안티에이징성분으로 활용된다. 상기 카퍼 트리펩타이드-1의 노화예방과 퍼밍 및 주름예방 효과는 과학적 실험을 통한 연구를 통해 확인된 사항이다.In other words, the copper tripeptide-1 (copper tripeptide-1) improves wound healing ability, enhances immune cell function, and has antioxidant and anti-inflammatory effects. It also promotes collagen synthesis and strengthens blood vessels in skin tissue. As a synthesized peptide, it is used for damage repair and anti-aging components. Aging prevention and firming and anti-wrinkle effect of the copper tripeptide-1 has been confirmed through research through scientific experiments.
본 발명에서 상기 카퍼 트리펩타이드-1(copper tripeptide-1)의 아미노산 서열은 글라이신을 아미노 말단기로 시작하여 히스티딘, 라이신 순서의 트리펩타이드가 카퍼 이온과 배위결합된 형태로, 구리(Cu)에 아미노산 서열이 Gly-His-Lys(G-H-K)로 결합될 수 있다. In the present invention, the amino acid sequence of the copper tripeptide-1 is a form in which a glycopetide-based peptide is coordinated with a copper ion, starting with glycine as an amino terminal group, and amino acids to copper (Cu). The sequence can be linked to Gly-His-Lys (GHK).
본 발명에서 상기 카퍼 트리펩타이드-1은 고체상 폴리머 지체를 이용하여 합성하는 고체상 펩타이드 합성 방법을 이용하여 제조될 수 있는데, 상기 카퍼 트리펩타이드-1은 당해 기술분야에서 공지된 자동 펩타이드 합성기를 이용하여 제조되거나 수동으로 직접 제조될 수 있고, 상기 카퍼 트리펩타이드-1의 합성방법은 당해 기술분야에서는 공지된 기술인 바 이에 대한 구체적인 설명은 생략하기로 한다.In the present invention, the copper tripeptide-1 may be prepared using a solid phase peptide synthesis method synthesized using a solid polymer retarder, and the copper tripeptide-1 is prepared using an automatic peptide synthesizer known in the art. Or it can be prepared directly, the synthesis method of the copper tripeptide-1 is a technique known in the art, so a detailed description thereof will be omitted.
상기 병풀 추출물은 혈액 순환을 촉진시키고 콜라겐 합성 촉진으로 피부 탄력을 증가시킨다. 또한, 상기 병풀 추출물은 붉어진 피부를 진정시켜 주고 소염, 진정작용이 뛰어나 여드름 피부에도 좋다.The centella extract increases blood circulation and promotes skin elasticity by promoting collagen synthesis. In addition, the centella extract soothing red skin and anti-inflammatory, soothing excellent acne skin.
상기 검정콩 추출물은 폴리페놀 성분을 함유하여 유해 산소로부터 피부 및 두피를 보호하고, 상기 판테놀은 세포분열을 촉진시키고 상피세포의 형성을 돕기 때문에 피부 재생을 돕는 효과가 있으며, 상기 루틴은 모세혈관을 강화하는 효과가 있다.The black soybean extract contains a polyphenol component to protect the skin and scalp from harmful oxygen, and the panthenol promotes cell division and helps the formation of epithelial cells, thereby helping to regenerate the skin, and the routine strengthens capillaries It is effective.
상기 발효흑삼 추출물은 하기의 제조방법으로 제조된 발효흑삼을 이용하여 제조될 수 있다.The fermented black ginseng extract may be prepared using fermented black ginseng prepared by the following method.
먼저, 품질이 우수한 수삼을 수확한 후 물에서 깨끗하게 세척하여 선별할 수 있다.First, after harvesting the excellent quality ginseng can be selected by washing clean in water.
상기 수삼은 크기에 따라서 구분하여 선별할 수 있고, 품종이 우수한 수삼을 이용할 수 있는데, 예를 들어, 상기 수삼은 6년근 수삼을 사용하고 굵기가 일정한 수삼을 사용하는 것이 바람직하다.The fresh ginseng can be classified and selected according to the size, it is possible to use a variety of excellent ginseng, for example, it is preferable to use a ginseng 6 years old ginseng and a regular ginseng.
다음으로, 상기 세척된 수삼을 포도즙 및 갈변 억제제에 침지시킬 수 있는데, 상기 포도즙 및 갈변 억제제는 1:1의 중량 비율로 혼합될 수 있고, 상기 갈변 억제제는 비타민 C 및 소금용액이 1:1의 중량 비율로 혼합될 수 있다.Next, the washed ginseng may be immersed in the juice and browning inhibitor, the juice and browning inhibitor may be mixed in a weight ratio of 1: 1, the browning inhibitor is a vitamin C and salt solution of 1: 1 It can be mixed in weight ratio.
상기 포도즙은 혈전 방지 및 고혈압, 동맥경화 및 심장질환 등 성인병 예방에 좋고 기억력 향상에 도움을 줄 수 있고, 상기 갈변 억제제로 사용되는 소금용액은 농도가 0.6 내지 0.6 중량%인 소금용액일 수 있으며, 상기 세척된 수삼 100 중량부에 대해 포도즙 및 갈변 억제제 80 내지 120 중량부의 중량 비율로 침지시킨 후 30 내지 60분 동안 유지시켜 진행될 수 있다.The grape juice is good for preventing blood clots and preventing adult diseases such as hypertension, arteriosclerosis and heart disease, and may help improve memory. The salt solution used as the browning inhibitor may be a salt solution having a concentration of 0.6 to 0.6% by weight. After immersing in a weight ratio of 80 to 120 parts by weight of the grape juice and browning inhibitor with respect to 100 parts by weight of the washed ginseng may be carried out by maintaining for 30 to 60 minutes.
그 다음으로, 상기 포도즙 및 갈변 억제제에 침지된 수삼을 꺼내서 상기 수삼을 증숙할 수 있다.Next, the ginseng can be steamed by taking out the ginseng immersed in the grape juice and browning inhibitor.
상기 수삼의 증숙은 상기 포도즙 및 갈변 억제제의 성분이 침투된 수삼을 100 내지 110℃ 온도의 수증기로 30분 내지 100분 동안 찜으로써 수행될 수 있는데, 상기 수삼의 증숙이 상기한 하한 범위 미만으로 수행되는 경우에는 충분한 증숙이 이루어지지 않는 문제점이 있고, 상기한 상한 범위를 초과하여 수행되는 경우에는 증숙 시간의 증가에 따른 효과의 차이가 미미할 수 있다.Steaming of the ginseng may be carried out by steaming the ginseng penetrated the components of the grape juice and browning inhibitor for 30 minutes to 100 minutes with steam at a temperature of 100 to 110 ℃, steaming of the ginseng is carried out below the lower limit If there is a problem that the sufficient steaming is not made, if it is performed beyond the above upper limit range, the difference in the effect of the increase in the steaming time may be insignificant.
이어서, 상기 증숙된 수삼을 건조한 후, 상기 건조된 수삼을 초산 또는 구연산 중 어느 하나 이상의 산으로 세척할 수 있다.Subsequently, after drying the steamed ginseng, the dried ginseng may be washed with one or more acids of acetic acid or citric acid.
상기 증숙된 수삼의 건조는 30 내지 35℃의 온도에서 3 내지 5일 동안 수행될 수 있는데, 일정한 온도를 맞추기 위하여 상기 증숙된 수삼의 건조는 건조기를 이용한 기계식 건조가 이용될 수 있다.Drying of the steamed ginseng may be performed for 3 to 5 days at a temperature of 30 to 35 ℃, to achieve a constant temperature, the dried steamed ginseng may be used for mechanical drying using a dryer.
또한, 상기 건조된 수삼은 초산 또는 구연산 중 어느 하나 이상의 산으로 세척함으로써, 추후 발효 공정을 거쳐 제조된 흑삼의 향미, 색택, 균열 및 내백 발생률의 개선효과가 있다.In addition, the dried ginseng is washed with any one or more acids of acetic acid or citric acid, thereby improving the flavor, color, cracking and whitening incidence of black ginseng prepared through a later fermentation process.
다음으로, 상기 세척된 수삼을 발효시키기 위해 수분이 흡수된 볏짚을 준비할 수 있다.Next, in order to ferment the washed ginseng may be prepared rice straw absorbed moisture.
상기 수분이 흡수된 볏짚은 발열에 의해 수삼을 발효시켜 흑삼으로 제조할 수 있는데, 상기 볏짚은 하기의 방법으로 준비된 볏짚이 사용될 수 있다.The straw is absorbed moisture can be prepared by fermenting ginseng by heating the black ginseng, the straw can be used straw prepared by the following method.
먼저, 수삼을 발효시키기 위하여 유기농 방식으로 재배된 볏짚을 정제수에서 세척하여 상기 볏짚의 이물질의 제거하고 일정한 길이(예를 들어, 5 내지 10cm의 길이)로 절단할 수 있다.First, in order to ferment ginseng, rice straw grown in an organic manner may be washed in purified water to remove foreign matters of the rice straw and cut into a predetermined length (eg, length of 5 to 10 cm).
다음으로, 상기 절단된 볏짚을 습윤 살균 처리할 수 있는데, 상기 절단된 볏짚을 습윤 살균 처리함으로써 상기 볏짚에 잔류할 수 있는 세균이나 곰팡이 등의 잡균을 사멸시키고, 추후 상기 볏짚을 이용하여 수삼을 발효시킬 때 생성될 수 있는 세균이나 곰팡이 등의 잡균 증식을 막을 수 있다.Next, the cut rice straw may be wet sterilized, and the germinated rice straw may be wet sterilized to kill various germs such as bacteria or mold remaining in the rice straw, and later fermented ginseng using the rice straw. It can prevent the growth of various bacteria such as bacteria and fungi that can be produced when the process.
본 발명에서 상기 볏짚의 습윤 살균 처리는 가압멸균기를 이용하여 수행되고, 130 내지 135℃ 온도의 증기를 30 내지 60분 동안 상기 볏짚에 공급함으로써 수행될 수 있다.Wet sterilization treatment of the rice straw in the present invention is carried out by using an autoclave, it can be carried out by supplying steam of 130 to 135 ℃ temperature to the rice straw for 30 to 60 minutes.
그 다음으로, 상기 습윤 살균 처리된 볏짚에 볏짚의 발효 또는 숙성을 촉진할 수 있는 발효균 및 배양액을 분무할 수 있다. 즉, 일반적으로 볏짚을 물에 충분히 침지하여 두면 수분을 함유하고 있는 볏짚의 발효가 진행되고, 상기 볏짚의 발효 중에 바실러스균 등이 증식하게 되어 볏짚이 발효될 수 있는데, 본 발명에서는 상기 볏짚에 발효균 및 배양액을 분무함으로써, 상기 볏짚의 발효를 촉진하고, 상기 볏짚의 발효열에 의해 흑삼의 발효를 촉진시킬 수 있다.Next, the wet sterilized rice straw may be sprayed with fermentation bacteria and culture medium which may promote fermentation or ripening of rice straw. That is, in general, when the rice straw is sufficiently immersed in water, fermentation of the straw containing water proceeds, and during the fermentation of the rice straw, Bacillus bacteria and the like may be multiplied, and the straw may be fermented. And by spraying the culture solution, it is possible to promote the fermentation of the rice straw, the fermentation of black ginseng by the heat of fermentation of the rice straw.
본 발명에서 상기 발효균으로는 공지의 고초균(바실러스 서브틸러스( Bacillus subtilis))이 포함되어 있는 고초균 침출수가 이용될 수 있고, 배양액은 펩톤, 맥아추출물(Malt extract), 시트르산나트륨(Sodium citrate), 제2인산칼륨(Potassium phosphate dibasic), 글루코스(Glucose) 및 증류수로 이루어지고, 상기 배양액은 펩톤 15 내지 25 중량부, 맥아추출물 5 내지 15 중량부, 시트르산나트륨 0.5 내지 1.5 중량부, 제2인산칼륨 0.1 내지 0.3 중량부, 글루코스 1 내지 3 중량부 및 증류수 100 내지 200 중량부의 중량 비율로 혼합되어 이루어질 수 있는데, 상기 고초균 침출수 및 배양액은 각각 고초균 침출수 20 내지 40 중량부 및 배양액 500 내지 1000 중량부의 중량 비율로 혼합되어 볏짚에 분무될 수 있다.In the present invention, as the fermentation bacteria known Bacillus subtilis Bacillus subtilis ( Bacillus subtilis ) can be used to leach water, the culture medium is peptone, malt extract (Malt extract), sodium citrate (Sodium citrate), Potassium phosphate dibasic (Potassium phosphate dibasic), glucose (Glucose) and distilled water, the culture medium is 15 to 25 parts by weight of peptone, 5 to 15 parts by weight of malt extract, 0.5 to 1.5 parts by weight of sodium citrate, potassium diphosphate 0.1 to 0.3 parts by weight, 1 to 3 parts by weight of glucose and 100 to 200 parts by weight of distilled water may be mixed, wherein the Bacillus leachate and the culture medium are 20 to 40 parts by weight of Bacillus leachate and 500 to 1000 parts by weight of the culture solution, respectively. It can be mixed in proportions and sprayed on rice straw.
상기 배양액에서 상기 펩톤은 단백질을 공급해주는 질소원으로서 미생물의 성장에 필요한 단백질을 공급해 주며, 상기 맥아추출물은 각종 미네랄, 비타민 B군, 아미노산이 포함되어 있어 미생물 성장에 도움을 줄 수 있으며, 상기 시트르산나트륨은 배양액의 pH를 조절하여 미생물의 성장에 최적화된 상태를 유지해 주는 무기질로, 영양을 공급해 줄 수 있고, 상기 글루코스는 발효균이 당을 대사하여 유기산을 만들어내는 중요한 성분으로 기능할 수 있다.In the culture medium, the peptone is a nitrogen source for supplying protein, and supplies the protein necessary for the growth of microorganisms, and the malt extract contains various minerals, vitamin B groups, and amino acids, which may help the growth of microorganisms, and the sodium citrate Silver is a mineral that maintains the optimized state for the growth of microorganisms by adjusting the pH of the culture medium, it can provide nutrition, and the glucose can function as an important component that fermentation bacteria metabolize sugar to produce organic acids.
본 발명에서 발효균으로 사용되는 고초균 침출수는 하기의 방법으로 얻을 수 있다.Bacillus subtilis used as fermentation bacteria in the present invention can be obtained by the following method.
먼저, 깨끗이 세척된 볏짚을 물이 담긴 용기에 넣고 110 내지 115℃의 온도에서 30 내지 60분 동안 삶아 살균함으로써 볏짚에 잔류하는 잡균을 제거할 수 있다. 본 발명은 상기와 같이 110 내지 115℃의 온도에서 30 내지 60분 동안 삶아 살균함으로써 곰팡이나 기타 잡균을 살균할 수 있는데, 고초균은 120℃ 이상의 온도에서 장시간 지나야 살균되기 때문에 고초균이 사멸되지 않도록 110 내지 115℃의 온도에서 30 내지 60분 동안 볏짚을 삶아 살균할 수 있다. First, cleansed rice straw is placed in a container containing water, and boiled and sterilized for 30 to 60 minutes at a temperature of 110 to 115 ° C. to remove germs remaining in the rice straw. The present invention can sterilize mold or other various bacteria by boiling for 30 to 60 minutes at a temperature of 110 to 115 ℃ as described above, because the subtilis bacterium is sterilized only after a long time at a temperature of 120 ℃ or more so as not to die Rice straw can be boiled and sterilized for 30 to 60 minutes at a temperature of 115 ° C.
다음으로, 상기와 같이 삶아 살균한 후 용기에 남긴 물을 자연 냉각함으로써 상기 용기에 남아 있는 물에 고초균이 함유된 고초균 침출수를 얻을 수 있다. Next, by boiling and sterilizing as described above, by cooling the water left in the container naturally, it is possible to obtain Bacillus subtilis leachate containing Bacillus subtilis in the water remaining in the container.
그 다음으로, 상기 볏짚이 침지되어 있는 고초균 침출수를 60 내지 70℃의 온도로 5 내지 10시간 동안 유지함으로써 상기 고초균 침출수에 포함되어 있는 고초균을 증식시킬 수 있다. 본 발명은 상기와 같이 고초균이 증식하기에 적합하도록 고초균 침출수를 60 내지 70℃의 온도로 유지하고, 상기 고초균이 증식될 때 필요한 영양분은 고초균 침출수에 침지되어 있는 볏짚으로부터 공급받을 수 있도록 함으로써 상기 고초균을 증식시킬 수 있다.Subsequently, by maintaining the Bacillus subtilis in which the rice straw is immersed at a temperature of 60 to 70 ℃ for 5 to 10 hours it is possible to propagate Bacillus subtilis contained in the Bacillus subtilis. The present invention maintains the Bacillus subtilis leachate at a temperature of 60 to 70 ℃ so that Bacillus subtilis is suitable for propagation as described above, and the nutrients required when the Bacillus microbial growth is to be supplied from rice straw immersed in Bacillus subtilis leachate Can multiply.
이어서, 상기와 같이 고초균이 증식된 고초균 침출수로부터 볏짚을 분리하여 제거하고, 상기 고초균 침출수만을 110 내지 115℃의 온도에서 25 내지 35분 동안 삶아 살균함으로써 고초균 증식과정에서 생성될 수 있는 잡균을 살균하여 제거하고, 상기 고초균 침출수를 자연 냉각함으로써 고초균이 포함되어 있는 고초균 침출수를 제조할 수 있다.Subsequently, by removing the rice straw from the subtilis of the Bacillus subtilis, which Bacillus subtilis was propagated as described above, and sterilizing only the Bacillus subtilis water at a temperature of 110 to 115 ° C. for 25 to 35 minutes to sterilize various germs that may be produced in Bacillus subtilis growth. By removing and naturally cooling the Bacillus subtilis, Bacillus subtilis can contain the Bacillus subtilis can be prepared.
그 다음으로, 상기 고초균 침출수 및 배양액이 분무된 볏짚과, 수삼을 혼합한 후 일정한 온도 및 습도로 유지하여 흑삼으로 발효시킬 수 있다.Subsequently, the rice straw sprayed with the Bacillus subtilis and the culture solution and the fresh ginseng may be mixed and then maintained at a constant temperature and humidity to ferment into black ginseng.
상기 발효는 상기 고초균 침출수 및 배양액이 분무된 볏짚과, 수삼을 각각 볏짚 200 내지 400 중량부 및 수삼 10 내지 30 중량부의 중량 비율로 혼합한 후, 65 내지 70℃의 온도 및 60 내지 65%의 습도를 유지하는 보관용기에서 5 내지 10일 동안 보관하여 발효함으로써 수삼을 발효시켜 흑삼을 얻을 수 있다.The fermentation is mixed with rice straw sprayed with the Bacillus subtilis and culture medium, ginseng 200 to 400 parts by weight and 10 to 30 parts by weight of fresh ginseng, respectively, the temperature of 65 to 70 ℃ and humidity of 60 to 65% By storing fermentation for 5 to 10 days in a storage container to maintain the fermented ginseng can be obtained black ginseng.
이어서, 상기 발효되어 제조된 흑삼을 건조하여 발효흑삼을 제조할 수 있다.Subsequently, the fermented black ginseng may be dried to prepare fermented black ginseng.
상기 발효흑삼은 상기 발효되어 제조된 흑삼을 분리한 후 4 내지 6℃의 온도에서 20 내지 40시간 동안 냉풍 건조하고, 60 내지 65℃의 온도로 5 내지 10일 동안 유지함으로써 상기 흑삼에 포함되어 있는 수분의 함량이 15 내지 20중량%가 되도록 건조할 수 있다.The fermented black ginseng is isolated from the fermented black ginseng and cold-dried for 20 to 40 hours at a temperature of 4 to 6 ℃, and is contained in the black ginseng by maintaining for 5 to 10 days at a temperature of 60 to 65 ℃ Drying may be such that the water content is 15 to 20% by weight.
다음으로, 상기 발효흑삼 100 중량부에 대해 물 1500 내지 200 중량부의 중량비율로 혼합한 후 115 내지 120℃의 온도 및 3 내지 4kgf/cm 2의 압력에서 1 내지 3시간 동안 가열함으로써, 발효흑삼 추출물을 제조할 수 있다.Next, the fermented black ginseng extract by mixing at a weight ratio of 1500 to 200 parts by weight of water with respect to 100 parts by weight of fermented black ginseng for 1 to 3 hours at a temperature of 115 to 120 ℃ and a pressure of 3 to 4 kgf / cm 2 , Can be prepared.
상기 파인애플 추출물은 하기의 제조방법으로 제조된 파인애플 추출물이 사용될 수 있다.The pineapple extract may be used pineapple extract prepared by the following manufacturing method.
먼저, 파인애플을 준비한 후 세척하여 이물질을 제거할 수 있다.First, the pineapple may be prepared and washed to remove foreign substances.
상기 파인애플의 세척은 탄산수소나트륨(NaHCO 3)이 용해된 정제수를 이용하여 세척할 수 있는데, 상기 탄산수소나트륨이 용해된 정제수를 이용하여 상기 파인애플의 표면을 세척함으로써, 상기 파인애플의 표면에 잔류되어 있는 농약 성분이나 중금속, 곰팡이 제거의 세척 효율을 향상시킬 수 있다.The pineapple may be washed by using purified water in which sodium hydrogen carbonate (NaHCO 3 ) is dissolved, and the pineapple remains on the surface of the pineapple by washing the surface of the pineapple using purified water in which sodium hydrogen carbonate is dissolved. It can improve the cleaning efficiency of pesticides, heavy metals and mold removal.
상기 탄산수소나트륨(NaHCO 3)은 식품첨가물로도 이용되는 것으로, 독성이 없으며 침투, 확산, 팽창 등의 기능을 가져 파인애플의 표면을 깨끗하게 세척할 수 있는데, 상기 탄산수소나트륨은 2 내지 4(w/w)% 농도 범위를 가지고, 20 내지 30℃의 온도에서 1 내지 5분 동안 세척하는 것이 바람직하다.The sodium hydrogen carbonate (NaHCO 3 ) is also used as a food additive, there is no toxicity and has a function of penetration, diffusion, expansion, etc., to clean the surface of the pineapple, the sodium hydrogen carbonate is 2 to 4 (w / w)% concentration range, it is preferred to wash for 1 to 5 minutes at a temperature of 20 to 30 ℃.
다음으로, 상기 세척된 파인애플을 분쇄할 수 있다.Next, the washed pineapple can be ground.
상기 파인애플의 분쇄는 짧은 시간 내에 파인애플으로부터 유효 성분이 추출될 수 있도록 하기 위하여 분쇄기 또는 믹서기 등을 이용하여 상기 파인애플을 0.5 내지 2cm의 직경으로 분쇄하여 사용할 수 있다.Grinding of the pineapple may be used by grinding the pineapple to a diameter of 0.5 to 2cm using a grinder or a blender in order to extract the active ingredient from the pineapple within a short time.
그 다음으로, 상기 파인애플을 증숙할 수 있다.Next, the pineapple can be steamed.
상기 파인애플의 증숙은 상기 분쇄된 파인애플을 가열하여 수증기로 찌는 것인데, 본 발명에서는 상기 파인애플을 효과적으로 증숙하기 위하여 제1 증숙 단계 및 제2 증숙 단계, 즉 두 단계의 증숙으로 수행될 수도 있다.The steaming of the pineapple is to steam the crushed pineapple to steam with steam. In the present invention, in order to effectively steam the pineapple, a first steaming step and a second steaming step, that is, two steps of steaming, may be performed.
예를 들어, 상기 파인애플의 증숙 과정에서 상기 제1 증숙 단계는 상기 분쇄된 파인애플을 60 내지 70℃ 온도의 수증기로 10 내지 30분 동안 가열하는 단계이고, 상기 제2 증숙 단계는 상기 가열된 파인애플을 80 내지 90℃ 온도의 수증기로 1 내지 3시간 동안 가열하는 단계이다.For example, in the steaming process of the pineapple, the first steaming step is heating the ground pineapple with steam at a temperature of 60 to 70 ° C. for 10 to 30 minutes, and the second steaming step is heating the pineapple. Heating for 1 to 3 hours with steam at a temperature of 80 to 90 ° C.
본 발명에서 상기 제1 증숙 단계가 60℃ 미만의 온도 또는 10분 미만으로 수행되는 경우에는 상기 파인애플의 표면과 외부가 수증기에 의해 균일하게 증숙되기 어려운 문제가 발생할 수 있고, 70℃ 초과의 온도 또는 30분을 초과하여 수행되는 경우에는 파인애플의 표면 및 내부의 온도가 균일하게 예열되어 더 이상의 효과 증가가 나타나지 않을 수 있다.In the present invention, when the first steaming step is performed at a temperature of less than 60 ℃ or less than 10 minutes, the surface and the outside of the pineapple may be difficult to uniformly steam by water vapor, a temperature of more than 70 ℃ or If it is performed for more than 30 minutes, the temperature of the surface and the inside of the pineapple may be uniformly preheated so that no further increase in effect may appear.
또한, 상기 제2 증숙 단계가 80℃ 미만의 온도 또는 1 시간 미만으로 수행되는 경우에는 상기 파인애플이 충분히 증숙되지 못하여 추후 공정에서 짧은 시간 내에 추출액을 제조하기 어렵고, 90℃ 초과의 온도 또는 3시간을 초과하여 수행되는 경우에는 상기 파인애플의 유효성분이 휘발되거나 파인애플의 물성이 약해지는 문제가 발생할 수 있다.In addition, when the second steaming step is performed at a temperature of less than 80 ° C or less than 1 hour, the pineapple is not sufficiently steamed, and thus it is difficult to prepare the extract in a short time in a subsequent process, and the temperature of more than 90 ° C or 3 hours. If it is performed in excess, the active ingredient of the pineapple may be volatilized or the physical properties of the pineapple may be weakened.
이어서, 상기 파인애플을 건조할 수 있다.Subsequently, the pineapple may be dried.
상기 파인애플의 건조는 상기 증숙된 파인애플을 65 내지 75℃의 온도에서 50 내지 200분 동안 수행될 수 있는데, 상기 파인애플의 건조가 65℃ 미만의 온도 또는 50분 미만으로 수행되는 경우에는 상기 증숙된 파인애플에 잔류하는 수분이 충분히 제거되기 어려운 문제가 발생할 수 있고, 75℃ 초과의 온도 또는 200분을 초과하여 수행되는 경우에는 더 이상의 잔류 수분이 제거되지 않거나 파인애플의 물성이 변하는 문제가 발생할 수 있다.The drying of the pineapple may be performed for 50 to 200 minutes at the steamed pineapple at a temperature of 65 to 75 ℃, if the drying of the pineapple is performed at a temperature below 65 ℃ or less than 50 minutes the steamed pineapple Problems may be difficult to sufficiently remove the residual water in the case, when the temperature is more than 75 ℃ or more than 200 minutes may not be removed any further residual moisture or the physical properties of the pineapple may occur.
다음으로, 상기 건조된 파인애플을 추출하여 파인애플 추출물을 제조할 수 있다.Next, the pineapple extract may be prepared by extracting the dried pineapple.
상기 건조된 파인애플의 추출은 용매 추출법, 열수 추출법 또는 초임계 추출법과 같은 공지된 추출법을 이용할 수 있는데, 예를 들어, 상기 파인애플 추출물의 제조는 (a) 건조된 파인애플 1000~1200g에 70%(v/v) 에탄올수용액 10~12ℓ로 85 내지 90℃에서 3~4시간 동안 1차 추출한 다음, 70%(v/v) 에탄올수용액 4~6ℓ로 85 내지 90℃에서 2~3시간 동안 2차 추출을 완료하고, 진공회전증발기에서 1000 내지 1200㎖이 될 때까지 추출액을 제조하는 단계; (b) 상기 추출액에 물을 가하여 2 내지 3배로 희석하고, 14,000~15,000rpm에서 20 내지 30분 동안 원심분리하여 고분자 섬유소 및 고형분을 완전히 제거한 다음, 모아진 상등액을 1.2~1.5배의 클로로포름으로 2회 추출하는 단계; 및 (c) 상기 클로로포름층을 제거하고, 수층을 1.2~1.5배의 에틸아세테이트로 3회 추출하여 파인애플 추출액을 제조하는 단계에 의해 파인애플 추출물을 제조할 수 있다.Extraction of the dried pineapple may use a known extraction method such as solvent extraction, hot water extraction or supercritical extraction, for example, the preparation of the pineapple extract (a) 70% (v) in 1000 ~ 1200g dried pineapple / v) First extraction with ethanol aqueous solution 10-12L for 3-4 hours at 85 to 90 ℃, then 70% (v / v) secondary extraction for 2 to 3 hours at 85-90 ℃ with 4-6L of ethanol aqueous solution To complete the step, preparing an extract until the 1000 to 1200ml in a vacuum rotary evaporator; (b) adding water to the extract 2 to 3 times, centrifuging at 14,000 to 15,000 rpm for 20 to 30 minutes to completely remove polymer fibers and solids, and then collecting the collected supernatant twice with 1.2 to 1.5 times chloroform. Extracting; And (c) removing the chloroform layer and extracting the aqueous layer three times with 1.2 to 1.5 times ethyl acetate to prepare a pineapple extract.
이하, 본 발명에 따른 양파 추출물을 포함하는 피부관리 화장료 조성물에 대한 실시예를 들어 더욱 구체적으로 설명하기로 한다.Hereinafter, an embodiment of the skin care cosmetic composition comprising an onion extract according to the present invention will be described in more detail.
< 실시예 1 ><Example 1>
양파 추출물 80 중량부, 카퍼 트리펩타이드-1(copper tripeptide-1) 10 중량부, 병풀 추출물 15 중량부, 검정콩 추출물 15 중량부, 판테놀 10 중량부 및 루틴 5 중량부의 중량 비율로 혼합하여 피부관리 화장료 조성물을 제조하였다.Skin care cosmetics by mixing 80 parts by weight of onion extract, 10 parts by weight of copper tripeptide-1, 15 parts by weight of centella extract, 15 parts by weight of black bean extract, 10 parts by weight of panthenol and 5 parts by weight of rutin The composition was prepared.
< 실시예 2 ><Example 2>
실시예 1과 동일한 조성물을 이용하여 피부관리 화장료 조성물을 제조하였는데, 실시예 2에서는 상기 양파 추출물 100 중량부에 대해 발효흑삼 추출물 15 중량부가 더 포함되도록 하여 화장료 조성물을 제조하였다.Using the same composition as in Example 1 to prepare a skin care cosmetic composition, in Example 2 to prepare a cosmetic composition by including 15 parts by weight of fermented black ginseng extract with respect to 100 parts by weight of the onion extract.
< 실시예 3 ><Example 3>
실시예 1과 동일한 조성물을 이용하여 피부관리 화장료 조성물을 제조하였는데, 실시예 3에서는 상기 양파 추출물 100 중량부에 대해 파인애플 추출물 10 중량부가 더 포함되도록 하여 화장료 조성물을 제조하였다.A skin care cosmetic composition was prepared using the same composition as in Example 1, but in Example 3, 10 parts by weight of pineapple extract was further included with respect to 100 parts by weight of the onion extract to prepare a cosmetic composition.
< 비교예 ><Comparative Example>
실시예 1과 동일한 조성물을 이용하여 피부관리 화장료 조성물을 제조하였는데, 비교예에서는 양파 추출물이 포함되지 않도록 하였다.A skin care cosmetic composition was prepared using the same composition as in Example 1, but the onion extract was not included in the comparative example.
1. 피부관리 화장료 조성물의 자극 실험1. Stimulation test of skin care cosmetic composition
상기와 같이 제조된 실시예 1의 피부관리 화장료 조성물에 대한 자극 임상실험을 다음과 같이 실시하였다.Stimulation clinical trials for the skin care cosmetic composition of Example 1 prepared as described above was carried out as follows.
먼저, 임상실험은 10세에서 50세 사이의 건강한 20명(남자 7명, 여자 13명)을 대상으로 하였는데, 실험시작 2주 전부터 종료시까지 스테로이드나 항생제 등 다른 제품은 사용하지 않았음을 확인하였다.First of all, clinical trials were conducted on 20 healthy men (7 males, 13 females) between 10 and 50 years old, and no steroids or antibiotics were used from 2 weeks before the end of the experiment. .
그리고 모든 실험 대상자에게는 문제가 없는 피부 부위에 피부관리 화장료 조성물을 비누 세안 후 일정량(3㎎/cm 2)씩 도포하고 24시간 후에 피부 상태(홍반, 부종, 구진 등)를 관찰하여 하기 [표 1]과 같은 평가표를 통한 정성적 평가를 수행하였다And all the subjects were applied to a certain amount (3 mg / cm 2 ) after washing the skin care composition with soap on the skin area without problems and observed the skin condition (erythema, edema, papules, etc.) after 24 hours [Table 1 Qualitative evaluation was carried out through the following evaluation table.
실험 항목Experiment item 주관적 점수Subjective score
자극 정도Stimulation degree a: 피부가 많이 붉게 되고 가려움도 강하다a: The skin is very red and itchy
b: 피부가 약간 붉게 되고 가려움이 있다b: skin becomes slightly red and itchy
c: 피부가 약간 붉게 되고 자극도 있다c: skin slightly reddened and irritated
d: 피부 상태는 변화 없으나 약간 자극이 있다d: skin condition remains unchanged but slightly irritating
e: 자극이나 피부상태 변화 없다e: No irritation or skin condition change
상기 [표 1]의 자극 정도에 대한 실험 대상자의 평가 결과는 하기의 [표 2]와 같다.Evaluation results of the test subjects on the degree of stimulation of the above [Table 1] are as shown in the following [Table 2].
실험 항목Experiment item 주관적 점수Subjective score 평가 결과Evaluation results
자극 정도Stimulation degree a: 피부가 많이 붉게 되고 가려움도 강하다a: The skin is very red and itchy --
b: 피부가 약간 붉게 되고 가려움이 있다b: skin becomes slightly red and itchy --
c: 피부가 약간 붉게 되고 자극도 있다c: skin slightly reddened and irritated --
d: 피부 상태는 변화 없으나 약간 자극이 있다d: skin condition remains unchanged but slightly irritating 1 명1 person
e: 자극이나 피부상태 변화 없다e: No irritation or skin condition change 19 명19 people
2. 흡수 정도 실험2. Absorption degree experiment
상기 실시예 1, 2 및 3과 비교예에 따라 제조된 피부관리 화장료 조성물을 이용하여 피부 및 모발에 도포한 후 흡수 정도를 평가하였다.After applying to the skin and hair using the skin care cosmetic composition prepared according to Examples 1, 2 and 3 and Comparative Examples to evaluate the degree of absorption.
상기 흡수 정도는 화장료 3g을 20명의 피험자 모발과 손에 도포한 후 흡수되는 정도에 대하여 관능 평가를 실시하였으며, 그 결과를 하기의 [표 4]에 나타내었다. 또한, 상기 관능 평가에 대한 점수 및 평가 기준은 5점 채점법을 이용하였으며, 점수 및 평가 기준은 하기의 [표 3]에 나타낸 바와 같다.The degree of absorption was applied to the hair and hands 20 subjects of cosmetics 3g, the sensory evaluation was performed for the degree of absorption, the results are shown in Table 4 below. In addition, the score and evaluation criteria for the sensory evaluation was used a five-point scoring method, the score and evaluation criteria are as shown in Table 3 below.
점수score 평가 기준(흡수 속도)Evaluation standard (absorption rate)
55 매우 빠름Very fast
44 빠름speed
33 보통usually
22 다소 느림Somewhat slow
1One 매우 느림Very slow
구분division 실시예 1Example 1 실시예 2Example 2 실시예 3Example 3 비교예Comparative example
피부흡수도Skin absorption 4.34.3 4.64.6 4.44.4 3.13.1
모발흡수도Hair absorption 4.54.5 4.54.5 4.34.3 3.33.3
상기 [표 4]를 참조하면, 실시예 1 내지 3의 경우 전반적으로 흡수도가 양호 내지 우수한 것을 확인할 수 있었다.Referring to [Table 4], in the case of Examples 1 to 3 it was confirmed that the overall good absorbency.
반면, 비교예의 경우 흡수 속도가 낮아 사용감이 좋지 않음을 확인할 수 있었다.On the other hand, in the case of the comparative example it was confirmed that the use rate is not good because the absorption rate is low.
이상, 본 발명의 바람직한 일 실시예를 설명하였지만, 본 발명이 속하는 기술분야에서 통상의 지식을 가진 자라면 본 발명이 그 기술적 사상이나 필수적인 특징을 변경하지 않고서 다른 구체적인 형태로 실시될 수 있다는 것을 이해할 수 있을 것이다. 그러므로 이상에서 기술한 일 실시예는 모든 면에서 예시적인 것이며 한정적이 아닌 것으로 이해해야만 한다.As mentioned above, although one preferred embodiment of the present invention has been described, those skilled in the art will understand that the present invention can be implemented in other specific forms without changing the technical spirit or essential features. Could be. Therefore, it should be understood that one embodiment described above is illustrative in all respects and not restrictive.
본 발명에 따른 양파 추출물을 포함하는 피부관리 화장료 조성물은 여드름, 피부염 예방을 위한 치료제 및 두피 또는 피부의 가려움 및 붉어짐을 완화하기 위한 화장품으로 사용될 수 있다.Skin care cosmetic composition comprising an onion extract according to the present invention can be used as a therapeutic agent for preventing acne, dermatitis and cosmetics to relieve itching and redness of the scalp or skin.

Claims (3)

  1. 양파 추출물, 카퍼 트리펩타이드-1(copper tripeptide-1), 병풀 추출물, 검정콩 추출물, 판테놀 및 루틴을 포함하는 조성물로서,A composition comprising onion extract, copper tripeptide-1, centella extract, black bean extract, panthenol and rutin,
    상기 조성물은 양파 추출물 50 내지 100 중량부, 카퍼 트리펩타이드-1(copper tripeptide-1) 5 내지 15 중량부, 병풀 추출물 10 내지 20 중량부, 검정콩 추출물 10 내지 20 중량부, 판테놀 5 내지 15 중량부 및 루틴 3 내지 8 중량부의 중량 비율로 포함하고,The composition is 50 to 100 parts by weight of onion extract, copper tripeptide-1 (copper tripeptide-1) 5 to 15 parts by weight, centella extract 10 to 20 parts by weight, black soybean extract 10 to 20 parts by weight, panthenol 5 to 15 parts by weight And in a weight ratio of 3 to 8 parts by weight of the routine,
    상기 조성물 이외에 발효흑삼 추출물을 더 포함하되,In addition to the composition further comprises fermented black ginseng extract,
    상기 양파 추출물 100 중량부에 대해 상기 발효흑삼 추출물이 10 내지 20 중량부의 중량 비율로 포함하고,The fermented black ginseng extract is contained in a weight ratio of 10 to 20 parts by weight based on 100 parts by weight of the onion extract,
    상기 양파 추출물은,The onion extract is,
    양파를 채취하여 1 내지 3(w/w)% 농도 범위 및 33 내지 37℃의 온도를 가지는 탄산수소나트륨(NaHCO 3)이 용해된 정제수로 1 내지 5분 동안 세척하여 양파에 부착되어 있는 이물질을 제거하고, 상기 양파의 껍질을 분리하여 양파 과육 및 양파 껍질로 분리하고, 상기 양파 과육을 건조기에서 건조하되, 상기 양파 과육의 건조는 온도 20 내지 25℃ 및 습도 33 내지 40%로 유지되는 건조기에서 3 내지 7시간 동안 건조하며, 상기 건조된 양파 과육을 정제수와 혼합한 후 가열하여 상기 양파 과육 추출물을 제조하되, 상기 양파 과육 추출물은 상기 건조된 양파 과육 100 중량부에 대하여 정제수 500 내지 1000 중량부를 혼합한 후 95 내지 105℃의 온도에서 5 내지 15시간 동안 가열함으로써 상기 양파 과육 추출물을 제조하고, 상기 양파 껍질을 건조하되, 상기 양파 껍질의 건조는 30 내지 35℃ 및 습도 35 내지 45%로 유지되는 건조기에서 3 내지 7시간 동안 건조하며, 상기 건조된 양파 껍질을 정제수와 혼합한 후 가열하여 상기 양파 껍질 추출물을 제조하되, 상기 양파 껍질 추출물은 상기 건조된 양파 껍질 100 중량부에 대하여 정제수 200 내지 400 중량부를 혼합한 후 60 내지 70℃의 온도에서 1 내지 3시간 동안 침지시킨 후, 상기 양파 껍질이 침지된 정제수를 가열기에 투입하고, 상기 가열기에 투입된 양파 껍질이 침지된 정제수를 110 내지 120℃의 온도 및 압력용기 내부 압력 2.5 내지 3.5kgf/cm 2의 범위에서 3 내지 5시간 동안 가열함으로써 상기 양파 껍질 추출물을 제조하고, 상기 양파 과육 추출물 및 양파 껍질 추출물을 혼합함으로써 양파 추출물을 제조하되, 상기 양파 추출물은 양파 과육 추출물 및 양파 껍질 추출물을 7:3 내지 6:4의 중량 비율로 혼합하며, 상기 양파 추출물을 3 내지 7℃의 온도에서 1 내지 5시간 보관함으로써 숙성시켜 제조되는 것을 특징으로 하는 양파 추출물을 포함하는 피부관리 화장료 조성물.Onions were collected and washed for 1 to 5 minutes with purified water dissolved in sodium bicarbonate (NaHCO 3 ) having a concentration range of 1 to 3 (w / w)% and a temperature of 33 to 37 ° C. to remove foreign substances adhering to the onion. Remove the onion skin, separate the onion skin and onion peel, and dry the onion flesh in a dryer, the drying of the onion flesh in a dryer maintained at a temperature of 20 to 25 ℃ and humidity 33 to 40% Drying for 3 to 7 hours, and mixed with the dried onion flesh and purified water to produce the onion flesh extract, the onion flesh extract is 500 to 1000 parts by weight of purified water with respect to 100 parts by weight of the dried onion flesh After mixing, the onion pulp extract was prepared by heating at a temperature of 95 to 105 ° C. for 5 to 15 hours, and drying the onion peel, while drying the onion peel. Is dried for 3 to 7 hours in a dryer maintained at 30 to 35 ℃ and humidity 35 to 45%, and mixed with the dried onion skin and purified water to produce the onion peel extract, the onion peel extract is After mixing 200 to 400 parts by weight of purified water with respect to 100 parts by weight of the dried onion skin, immersed for 1 to 3 hours at a temperature of 60 to 70 ℃, the onion skin is immersed in purified water, the heater The onion peel extract is prepared by heating purified onion in which the onion skin is immersed in a temperature of 110 to 120 ° C. and a pressure vessel in the range of 2.5 to 3.5 kgf / cm 2 for 3 to 5 hours, and the onion flesh extract and To prepare an onion extract by mixing the onion peel extract, the onion extract is the onion flesh extract and onion peel extract 7: 3 to 6: Mixing in a weight ratio of 4, skin care cosmetic composition comprising an onion extract characterized in that the onion extract is prepared by aging by storing for 1 to 5 hours at a temperature of 3 to 7 ℃.
  2. 제 1항에 있어서,The method of claim 1,
    상기 카퍼 트리펩타이드-1(copper tripeptide-1)의 아미노산 서열은 구리(Cu)에 아미노산 서열이 Gly-His-Lys(G-H-K)로 결합되는 것을 특징으로 하는 양파 추출물을 포함하는 피부관리 화장료 조성물.The amino acid sequence of the copper tripeptide-1 (copper tripeptide-1) is a skin care cosmetic composition comprising an onion extract, characterized in that the amino acid sequence is bonded to copper (Cu) Gly-His-Lys (G-H-K).
  3. 제 2항에 있어서,The method of claim 2,
    상기 조성물 이외에 파인애플 추출물을 더 포함하되,In addition to the pineapple extract in addition to the composition,
    상기 양파 추출물 100 중량부에 대해 상기 파인애플 추출물은 5 내지 15 중량부의 중량 비율로 포함되는 것을 특징으로 하는 양파 추출물을 포함하는 피부관리 화장료 조성물.Skin care cosmetic composition comprising an onion extract, characterized in that the pineapple extract is contained in a weight ratio of 5 to 15 parts by weight based on 100 parts by weight of the onion extract.
PCT/KR2019/009472 2018-08-10 2019-07-30 Skin care cosmetic composition comprising onion extract WO2020032460A1 (en)

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