JP2005089427A - Skin care preparation for external use - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a skin care preparation for external use stably blended with a component originated from a natural material, excellent in skin-beutifying effect and humectant effect. <P>SOLUTION: This preparation contains a water layer part obtained by filtering compressed juice of Momordica grosvenorii with a nano-filter. Also, the preparation for skin beautifying contains the water layer part obtained by filtering the compressed juice of the Momordica grosvenorii with the nano-filter as a skin-beutifying ingredient. Further, the preparation for aging prevention contains the water layer part obtained by filtering the compressed juice of the Momordica grosvenorii with the nano-filter as a skin-humectant. <P>COPYRIGHT: (C)2005,JPO&NCIPI

Description

  The present invention relates to a novel highly safe skin external preparation characterized by containing an aqueous layer part obtained by filtering pressed fruit juice of (Momordica grosvenorii) with a nanofilter, and its application field For example, it can be used for skin external preparations such as cosmetics, quasi-drugs, external medicines, etc. In more detail, the aqueous layer obtained by filtering the squeezed fruit juice of Rakan fruit with a nano filter is used as a skin beautifying ingredient. It contains a skin external preparation for beautifying skin that is excellent in the effect of improving skin dullness and transparency, and furthermore, an aqueous layer part obtained by filtering the pressed juice of Rakan fruit with a nano filter as a moisturizing ingredient It contains and relates to a skin external preparation for preventing aging such as preventing rough skin and wrinkles.

  Conventionally, skin external preparations such as emulsions, creams, skin lotions, cosmetic liquids, packs, cleaning agents, dispersions, ointments, aerosols, poultices, liniments, etc. have the purpose of imparting a prescribed medicinal effect to them. Various medicinal agents have been added. For example, alpha-hydroxy acids (AHA) such as lactic acid and citric acid, and beta-hydroxy acids such as salicylic acid are added as a beautifying skin component for the purpose of removing dull skin thickened by aging and improving dullness and transparency. (See Non-Patent Document 1). Glycerin, propylene glycol, saccharides, amino acids and the like are added as moisturizing ingredients for improving skin texture, rough skin, wrinkles and the like (see Non-Patent Documents 2 to 4).

  On the other hand, as the formulation of Luo Han Gong to the external preparation for skin, Luo Gan Gum and its extract are blended to prevent skin diseases such as dermatitis (see Patent Document 1), La Kanka extract, anti-allergic agent, Examples include antihistamines, anti-complement activators, and external preparations for skin containing hyaluronidase inhibitors (see Patent Document 2).

Fragrance Journal Vol.22, No. 12, pp. 38-42 Fragrance Journal Vol. 4, no. 1, page 81 Fragrance Sijourna Vol. 4, no. 1, page 86 Fragrance Journal Vol. 23, no. 1, pages 71-79 JP-A-10-130137 (Claims) JP 10-053532 A (claim)

  However, with the skin beautifying ingredients and moisturizing ingredients described above, the irritation to the skin is strong, or the desired medicinal effects may not be obtained due to deterioration in the preparation, etc. There was also a problem of poor usability. In addition, as a recent additive for external preparations for skin, there is a tendency that components derived from natural substances are preferred over chemical substances in terms of safety and the like. Therefore, development of the component derived from the natural substance which can solve said subject was desired.

  In view of the above circumstances, the present inventors have conducted extensive studies on components that can be used as a medicinal component of an external preparation for skin. As a result, water obtained by filtering compressed fruit juice of Modagrosvenorii with a nanofilter is obtained. The layer part (hereinafter simply referred to as “Rakan fruit water”) has a skin beautifying effect and a moisturizing effect, and a skin external preparation containing these is highly safe, stable, skin beautifying effect and moisturizing effect. The present invention was completed.

  That is, this invention relates to the skin external preparation containing the fruit water of Rakan fruit. In addition, the present invention relates to a skin external preparation containing the fruit water of Rahan fruit as a beautifying skin component or a skin external preparation containing a moisturizing component. Furthermore, the present invention relates to a skin external preparation for beautifying skin containing the fruit water of Rakan fruit or a skin external preparation for preventing aging.

  The skin external preparation containing the fruit water of Rahan fruit of the present invention is highly safe without irritation to the skin, and the skin external preparation containing the fruit water of Rakan fruit improves dullness, transparency, etc. Skin external preparations that have excellent effects on skin or that contain the fruit water of Rahan fruit as a moisturizing ingredient, have excellent skin beautifying effects such as improving skin texture, rough skin, skin folds, wrinkles, etc. It was an agent.

Hereinafter, the present invention will be described in detail.
The “Longan fruit” used in the present invention is a plant belonging to the cucurbitaceae family and originating in China and the like.

  The fruit water of Rahan fruit used in the present invention is obtained by pressing the fruit of Rahan fruit and filtering it using a nano filter in order to remove impurities. If the squeezed fruit juice is not filtered through a nanofilter and is used as it is for a topical skin preparation, it may cause turbidity, precipitation, or the like, and the uniformity of products such as bumps and foreign matters may be impaired. The nanofilter (NF membrane) used in the present invention can filter a filter having a size of approximately 0.001 μm or more, and a filter having a molecular weight of approximately 500 or more. Fruit water can be obtained. Examples of components contained in the fruit water of Rahan fruit of the present invention include sugars, minerals (calcium, sodium, potassium, magnesium, etc.), trace amounts of vitamin E, and the like. The obtained fruit water of Rakan fruit may be further subjected to a purification treatment such as deodorization and decoloration as long as it does not affect the effects of the present invention. Furthermore, an antifungal agent (phenoxyethanol, paraoxybenzoic acid esters), ethanol, 1,3-butylene glycol, and the like may be added in an appropriate amount for antiseptic purposes as necessary.

  Since the fruit water of Rakan fruit of the present invention has a skin beautifying effect and a moisturizing effect, the skin external preparation for beautifying skin that promotes metabolism of the stratum corneum thickened due to, for example, aging, etc., and improves skin dullness and transparency, Alternatively, it can be used for an anti-aging skin external preparation for preventing and improving rough skin and pruritus caused by dry skin, and preparing skin texture.

  The fruit water of Rahan fruit of the present invention can be used, for example, as a skin lotion as it is, or it can be diluted and applied directly to the skin or hair, but in general, as a component that replaces the water in the skin external preparation component. , All or part of them. Therefore, the blending amount is not particularly limited, but is 0.1 to 99% by mass (hereinafter simply referred to as “%”), preferably 1 to 90%, more preferably 5 to 87%.

  Further, the fruit water of Rahan fruit of the present invention contains various medicinal agents usually used for external preparations for skin, such as whitening agents, antioxidants, anti-inflammatory agents, cell activators, UV inhibitors, humectants, blood circulation promoters. The effect of the present invention can be further enhanced by incorporating it into a skin external preparation in combination with one or more medicinal agents selected from antibacterial / bactericidal agents and sebum secretion inhibitors.

  For example, when the fruit water of Rahan fruit in the present invention and a whitening agent are used in combination, the skin whitening effect inherent in the whitening agent is synergistically added in addition to the effect of improving the dullness of the fruit water of Rakan fruit in the present invention, and the skin for skin with higher effectiveness. An external preparation can be provided. In addition, in combination with other medicinal agents, in addition to the effects of the fruit water of Rahan fruit in the present invention, the original effects of other medicinal agents are added, and a skin external preparation having an improved effect synergistically can be provided.

  Specific examples of these medicinal agents are shown below. Here, “derivatives” include esters and salts that can be formed. Moreover, since one thing may have a some medicinal effect, there exist some which described the same name to the some medicinal agent. (In the case of plants, the names of other crude drugs are listed in parentheses.)

(Whitening agent)
Examples of whitening agents include vitamin C and its derivatives (dipalmitic acid-L-ascorbyl, tetraisopalmitic acid-L-ascorbyl and other L-ascorbic acid alkyl esters, L-ascorbic acid phosphates, L-ascorbic acid sulfates). Etc.), placenta extract, glabrizine, glabrene, liquiritin, isoliquiritin and licorice extract, yokoinin extract, oganone extract, seaweed extract (comb, macombu, wakame, hijiki, hibamata) , Sugime, Trollocombu, Kajime, Tsuruarame, Chigaiso, Honda Walla, Giant Kelp, etc .; Brown algae; Proboscis, Greater Rhinoceros, Giraffe Red algae such as Mentau, Igis, Egonori; Chlorella, Aonori, Donariella, Chlorococcus, Anaaaosa, Kawanoori, Marimo, Shiogusa, Casanori, Futojuzumo, Tamajusmo, Aeguro, Aomydra, etc .; Cyanobacteria such as Spirulina , Grape extract, wheat extract, tomato extract, carotenoids (carotene, lycopene, astaxanthin, etc.), agarose, oligosaccharide, hydroquinone and its derivatives, cysteine and its derivatives, asparagus extract, Ibukitorano extract, Neubara (AGES) extract, Ezokogi extract, pea extract, chamomile extract, keiket extract, orange extract, raspberry extract, kiwi extract, Clara extract, coffee extract, sesame oil, Sesame oil, Sesame extract, Rice extract, Rice extract, Saishin extract, Hawthorn extract, Sunpens extract, Peonies extract, Shirayuri extract, Mulberry extract, Beech extract, Beech Bud extract, black currant extract, hop extract, micaika (maikai, hamanasu) extract, mokka (bokeh) extract, yukinoshita extract, tea extract (Oolong tea, black tea, green tea, etc.), ganoderma extract, Examples include microbial fermentation metabolites, soybean extract, and molasses extract.

(Antioxidant)
Antioxidants include vitamin E and its derivatives (dl-α (β, γ) -tocopherol, dl-α-tocopherol acetate, dl-α-tocopherol nicotinate, dl-α-tocopherol linoleate, dl-succinate Tocopherols such as α-tocopherol and derivatives thereof, ubiquinones and the like, vitamin A and derivatives thereof (retinol palmitate, retinol acetate such as retinol and derivatives thereof such as dehydroretinal), carotenoids (carotene, lycopene, Astaxanthin), quercetin, dibutylhydroxytoluene, butylhydroxyanisole, vitamin B and its derivatives (thiamine hydrochloride, thiamine sulfate, riboflavin, riboflavin acetate, pyridoxine hydrochloride, pyridoxine dioctanoate) , Flavin adenine dinucleotide, cyanocobalamin, folic acid, nicotinic acid amide, nicotinic acid such as benzyl nicotinate, choline, etc.), vitamin C and its derivatives (dipalmitate-L-ascorbyl and tetraisopalmitate-L-ascorbyl) L-ascorbic acid alkyl esters, L-ascorbic acid phosphates, L-ascorbic acid sulfates, etc.), vitamin D and its derivatives (ergocalciferol, cholecalciferol, dihydroxystannal etc.), rutin, thiotaurine, Taurine, hydroquinone and its derivatives, histidine, catechin and its derivatives, grabrizine, glabrene, liquiritin, isoliquiritin and licorice extract containing these, glutathione and its derivatives, gallic acid and Derivatives thereof, cucumber extract, caquette extract, gentian (gentian) extract, gentian extract, cholesterol and derivatives thereof, hawthorn extract, peonies extract, superoxide dismutase, ginkgo biloba extract, sorghum (ogon) extract, Carrot extract, Maikai (Maikai, Hermanus) extract, Sunpens (Kawara ketsume) extract, Tormentilla extract, Parsley extract, Grape extract, Button (Poppi) extract, Mannitol, Mokka (Bokeh) extract, Melissa extract , Yashajitsu (Yasha) extract, Yukinoshita extract, Rosemary (mannenrou) extract, lettuce extract, tea extract (Oolong tea, black tea, green tea, etc.), microbial fermentation metabolites, seaweed extract, ganoderma extract Eggshell membrane extract, placenta extract, etc. It is below.

(Anti-inflammatory agent)
Anti-inflammatory agents include glycyrrhizic acid and its derivatives, glycyrrhetinic acid and its derivatives, vitamin B and its derivatives (thiamine hydrochloride, thiamine sulfate, riboflavin, riboflavin acetate, pyridoxine hydrochloride, pyridoxine dioctanoate, flavin adenine dinucleotide , Cyanocobalamin, folic acid, nicotinic acid amide, nicotinic acid such as benzyl nicotinate, choline, etc.), sulfur and its derivatives, aloe extract, ashitaba extract, artea extract, arnica extract, nettle extract, incovy ( Kawamomogi) extract, Turmeric extract, Yellowfin extract, Hypericum extract, Chamomile extract, Comfrey extract, Honeysuckle extract, Watercress extract, Salvia (sage) extract, Lemoko extract, perilla extract, birch extract, elder extract, larva extract, mugwort extract, eucalyptus extract, mugwort extract, forsythia extract, chondroitin sulfate and its derivatives, zinc oxide Etc.

(Cell activator)
Examples of cell activators include vitamin A and derivatives thereof (retinol palmitate, retinol acetate and the like, retinals such as dehydroretinal and derivatives thereof), carotenoids (carotene, lycopene, astaxanthin, etc.), vitamin B and the like Derivatives (thiamine hydrochloride, thiamine sulfate, riboflavin, riboflavin acetate, pyridoxine hydrochloride, pyridoxine dioctanoate, flavin adenine dinucleotide, cyanocobalamin, folic acid, nicotinic acid amide, nicotinic acid benzyl, nicotinic acid, choline, etc.) Vitamin C and its derivatives (dipalmitic acid-L-ascorbyl and tetraisopalmitic acid-L-ascorbyl, etc. L-ascorbic acid alkyl esters, L-ascorbic acid phosphates, L-a Corvate sulfate, etc.), ribonucleic acid and salts thereof, deoxyribonucleic acid and salts thereof, α- and γ-linolenic acid, xanthine and derivatives thereof (caffeine etc.), almond extract, asparagus extract, amino acids and derivatives thereof (Serine, glutamic acid, theanine, hydroxyproline, pyrrolidone carboxylic acid, etc.), apricot extract, ginkgo biloba extract, docosahexaenoic acid and its derivatives, eicosapentaenoic acid and its derivatives, yellow leaf extract, barley (bakuga) ) Extract, malt root extract, kiwi extract, cucumber extract, citric acid, lactic acid, malic acid, succinic acid, shiitake extract, horsetail extract, assembly extract, soybean extract, jujube extract , Communis extract, red pepper extract, red pepper extract , Tomato extract, garlic extract, carrot extract, hinoki thiol, beech extract, grape seed oil, beech extract, beech bud extract, peach extract, eucalyptus extract, lily extract, lettuce extract, lemon Extract, rosemary (mannenrou) extract, animal-derived extract (mollusk and other mollusc extracts, seashell extract, shellfish extract, fish meat extract, chicken crown extract, silk protein and its degradation product, placenta extract Serum deproteinized extract, royal jelly, lactoferrin or a degradation product thereof), yeast extract, microbial fermentation metabolite (derived from lactic acid bacteria, bifidobacteria, etc.), ganoderma extract and the like.

(UV protection agent)
Examples of UV inhibitors include paramethoxycinnamate-2-ethylhexyl, 4-tert-butyl-4'-methoxydibenzoylmethane, oxybenzone and derivatives thereof (2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4- Methoxybenzophenone-5-sulfonic acid, sodium 2-hydroxy-4-methoxybenzophenone-5-sulfonate, etc.), titanium oxide, fine particle titanium oxide, zinc oxide, fine particle zinc oxide and the like. When inorganic powders such as titanium oxide and zinc oxide are fine particles, higher effects are exhibited.

(Humectant)
As humectants, glycerin, 1,3-butylene glycol, proteins or derivatives or hydrolysates thereof and salts thereof (collagen, elastin, keratin, etc.), mucopolysaccharides and derivatives thereof (hyaluronic acid, chondroitin sulfate, etc.), Amino acids and derivatives thereof (histidine, serine, glycine, theanine, aspartic acid, arginine, pyrrolidone carboxylic acid, etc.), saccharides (sorbitol, erythritol, trehalose, inositol, glucose, xylitol, sucrose and derivatives thereof, dextrin and derivatives thereof, honey Etc.), D-panthenol and derivatives thereof, glycolipid, ceramide, achacha extract, almond extract, ashitaba extract, avocado extract, altea extract, arnica extract, hot spring water, aloe extract, cormorant Venetian extract, Scutellaria (Ogon) extract, Auren extract, Hypericum extract, Adrianthus extract, Onis extract, Chamomile extract, Oat extract, Gravulidine, Gravuren, Liquiritin, Isoliquiritin and licorice extract containing these , Raspberry extract, honeysuckle (Kinginka) extract, quince seed extract, Clara (Kujin) extract, gardenia extract, Kumazasa extract, grapefruit extract, watercress extract, gentian extract, Gennoshoco extract, burdock extract , Wheat extract, Comfrey extract, Saishin extract, Cactus extract, Savon extract, Salvia (sage) extract, Hawthorn extract, Giant extract, Perilla extract, Citrus extract, Peonies Extract Ginger extract, ginger extract, white birch extract, mallow extract, mulberry extract, thyme extract, camellia extract, cordyceps extract, dokudami extract, tormentilla extract , Parsley extract, peppermint extract, pearl extract, sunflower extract, rose extract, cypress extract, sunflower extract, dandelion extract, butcher's bloom extract, grape extract, prune extract, loofah extract , Bodaij extract, button extract, hop extract, pine extract, quince extract, marronnier extract, mukuroji extract, mucin, melissa extract, cornflower extract, saxifrage extract, lily extract, Lime extract, lavender extract, apple extract, gentian (ryuta N) extracts, phospholipids derived from soybeans and eggs, forsythia extract, bitumen extract, tea extracts (Oolong tea, green tea, black tea, etc.), urea, seaweed extract and the like.
Furthermore, as moisturizing (emollient) agents by sealing the skin surface, jojoba oil, macadamia nut oil, olive oil, apricot oil, persic oil, safflower oil, sunflower oil, avocado oil, medhome oil, camellia oil, almond oil, egoma oil , Sesame oil, borage (borage) oil, cacao butter, shea butter and the like.

(Blood circulation promoter)
As a blood circulation promoter, Arnica extract, chili pepper tincture, ginkgo biloba extract, tocopherol acetate, γ-oryzanol, etc. are used for the purpose of promoting melanin excretion by promoting blood flow in the skin, and lipase, Papain etc. are mentioned.

(Antimicrobial / bactericidal agent)
Examples of the antibacterial / bactericidal agent include salicylic acid, sulfur, benzoic acid, sodium benzoate, parachlorometacresol, benzalkonium chloride, isopropylmethylphenol, and the like.

(Sebum secretion inhibitor)
As sebum secretion inhibitors, pyridoxine and its derivatives and their salts, biotin, zinc oxide, aluminum chloride, aluminum hydroxychloride, citric acid and its salts, seawater dried product, aloe extract, Ibukitora noo extract, abalone extract Watercress extract, Melissa extract, Hamamelis extract, black tea extract, green tea extract, oolong tea extract, horsetail extract, hop extract, rosemary extract, lauren extract and the like.

  These whitening agents, antioxidants, anti-inflammatory agents, cell activators, UV inhibitors, moisturizers, blood circulation promoters, antibacterial / bactericidal agents, and sebum secretion inhibitors may be used alone or in combination of two or more. it can.

  In addition, the skin external preparation of the present invention is other than the above-mentioned components, and various components usually used in cosmetics, quasi-drugs, external medicines, etc., that is, water, alcohol, oil agent, surfactant, Thickeners, powders, chelating agents, pH adjusters, extracts derived from animals and plants / microorganisms, fragrances, and the like can be appropriately added as long as the effects of the present invention are not impaired.

  For example, as alcohols, monohydric alcohols such as ethyl alcohol and polyhydric alcohols such as propylene glycol and dipropylene glycol can be used for the purpose of dissolution, refreshing feeling, preserving, etc., as long as they do not overlap with the above components. .

  The oil agent can be used regardless of its origin and properties as those that improve usability and usability within a range that does not overlap with the above components. For example, liquid paraffin, squalane, triglyceride oils other than the above moisturizing (emollient) agents, ester oils other than the above moisturizing (emollient) agents, waxes, fatty acids, higher alcohols, silicone oils, fluorine oils, various waxes, etc. It is.

  Surfactants are used for emulsification, solubilization, dispersion, etc. of oils, fragrances, powders, and the like, and anionic, cationic, nonionic and amphoteric active agents can be used.

  As a thickener, it can be used regardless of the origin of chemical synthesis products or natural products such as carboxyvinyl polymer, carrageenan, agar, xanthan gum, dextrin fatty acid ester, organically modified clay mineral, etc. . These components can be used not only for adjusting the viscosity of the system but also for gelation, moisture retention, film formation and the like.

  The powder may be composite or surface-treated to improve usability and usability, regardless of shape, particle size, porosity, crystal structure, and the like. In the range not overlapping with the above ingredients, inorganic powders such as talc, mica, sericite and silicic acid, organic powders such as nylon powder, pearl pigments such as fish scale foil and bismuth oxychloride, iron oxide, carbon black, ultramarine And other inorganic pigments, tar dyes and lakes thereof, natural dyes and the like are used depending on the intended use.

  In order to prevent deterioration of the quality of the components in the system, a pH adjuster using a chelating agent such as EDTA or a buffer such as an acid-its salt can be used as long as it does not overlap with the above components.

  The extracts derived from animals, plants and microorganisms can be used without overlapping with the above components.

  The topical skin preparation of the present invention includes emulsions, creams, lotions, cosmetics, packs, hair tonics, cleansing agents (face wash, shampoo, rinse, etc.), foundations, dispersions, ointments, aerosols, poultices, liniments It can be used in various forms such as an agent.

  Next, the present invention will be described more specifically with reference to production examples, test examples, and examples, but the present invention is not limited thereto.

(Production Example 1) Production of fruit water of Rahan fruit:
About 3.0 kg of pressed fruit juice was obtained from dried Rakan fruit (3.2 kg). About 2.8 kg of distillate was obtained by leaving a part of the pressed fruit juice and filtering the remaining part with a nanofilter. The fruit water of Rakan fruit thus obtained was almost colorless and transparent. Further, the remaining part is the fruit juice (Rakan fruit juice) and the filter paper (No5C) filtered without filtration (Rakan fruit filter paper juice), and the examples shown in Table 1 and the samples of the comparative examples To do.

(Test example)
The lotions shown in Table 1 were prepared and subjected to the following tests.

(Manufacturing method)
Components (1) to (7) were mixed and dissolved, added to components (8) to (11), and mixed uniformly to obtain a lotion.

  Since the lotion of Comparative Example 2 was unsuitable as a lotion immediately after production and the lotion of Comparative Example 3 was unsuitable as a lotion on the next day of production, the following test was omitted.

(Test Example 1) Evaluation of skin-beautifying effect Using 10 panelists aged 27 to 52 years old and using the face of the face lotion of Example 1 shown in Table 1, using test (dullness, transparency, beam) , Evaluated flexibility and moist feeling) for one month. To the remaining half of the face of each panel, the skin lotion of Comparative Example 1 was used and evaluated by comparison with the skin lotion of Comparative Example 1. Specific evaluation is represented by the average score of the evaluation scores based on the evaluation criteria shown below, and the evaluation results are shown in Table 2.

(Evaluation criteria)
The degree of improvement in dullness, transparency, elasticity, flexibility and moistness was evaluated by the following points.
Evaluation score (comparison with Comparative Example 1);
3 (very good)
2 (Excellent)
1 (Slightly better)
0 (Do not change)
-1 (slightly inferior)
-2 (Inferior)
-3 (very inferior)

  As is apparent from Table 2, it was confirmed that the lotion of Example 1 containing the fruit water of Rakan fruit of the present invention has an excellent skin beautifying effect as compared with the lotion of Comparative Example 1 using purified water. It was.

(Test Example 2) Evaluation of moisturizing effect After applying the lotion of Example 1 shown in Table 1 on the inner side of the upper arm for 10 panels of Test Example 1, the change in electrical conductivity over time was measured. (A skin surface horn layer moisture content measuring apparatus manufactured by IBS Co., Ltd .: MODEL SKICON-200 was used) to determine the change in moisture content over time, and the moisturizing effect was evaluated. For the lotion of Comparative Example 1, the same measurement was performed by applying the lotion to the inside of the other upper arm of each panel. The results of plotting the average of these measured values against the measurement time are shown in FIG.

  As is clear from FIG. 1, each lotion of Example 1 of the present invention showed a good moisturizing effect as compared with the lotion of the comparative example.

The skin external preparation of various dosage forms containing the steam distilled water of this invention is illustrated below.
(Example 2) Shampoo (Ingredient) (%)
(1) Lauryl sulfate triethanolamine 5.0
(2) Polyoxyethylene (3) Lauryl ether Sodium sulfate 12.0
(3) 1,3-butylene glycol 4.0
(4) Lauric acid diethanolamide 2.0
(5) Edetate disodium 0.1
(6) Isopropylmethylphenol 0.5
(7) Methyl paraoxybenzoate 0.1
(8) Rakan fruit water * 1 Remaining amount * 1 Produced in Production Example 1

(Manufacturing method)
A. Ingredients (1) and (2) are heated and mixed and maintained at 70 ° C.
B. Ingredients (3) to (8) are heated and mixed and maintained at 70 ° C.
C. B was added to A and mixed, and then cooled to obtain a shampoo.

(Example 3) Rinse (Ingredient) (%)
(1) Cetyltrimethylammonium chloride 1.5
(2) Cetanol 2.5
(3) Squalane 2.0
(4) Polyoxyethylene (10) stearyl ether 1.0
(5) 1,3-butylene glycol 5.0
(6) Seaweed extract * 1 1.0
(7) Methyl paraoxybenzoate 0.1
(8) Fruit water of Rakan fruit * 2 Remaining amount * 1 Made by Maruzen Pharmaceutical * 2 Made in Production Example 1

(Manufacturing method)
A. Ingredients (1) to (4) are heated and mixed and maintained at 70 ° C.
B. Ingredients (5) to (8) are heated and mixed and maintained at 70 ° C.
C. B was added to A and mixed. After uniformly emulsifying, the mixture was cooled to obtain a rinse.

  Example 2 and Example 3 were shampoos and rinses that were excellent in stability over time and, as a result of being applied to the scalp and hair, can keep the scalp healthy and make the hair smooth and smooth.

(Example 4) Lotion (Ingredient) (%)
(1) Glycerol 3.0
(2) 1,3-butylene glycol 2.0
(3) Propylene glycol 4.0
(4) Oleyl alcohol 0.1
(5) Polyoxyethylene monolaurate (20)
Sorbitan 1.5
(6) Polyoxyethylene (20) lauryl ether 0.5
(7) Plant squalane * 1 0.2
(8) Ethyl alcohol 20.0
(9) Methyl paraoxybenzoate 0.1
(10) dl-α-tocopherol acetate * 2 0.2
(11) Paramethoxycinnamic acid-2-ethylhexyl 0.5
(12) Dipotassium glycyrrhizinate * 3 0.5
(13) Thyme extract * 4 1.0
(14) Sodium dl-pyrrolidonecarboxylate * 5 0.2
(15) Locust bean gum 1.0
(16) Phosphate-L-ascorbyl magnesium * 6 3.0
(17) Yokuinin extract * 7 1.0
(18) Rakan fruit water * 8 Remaining * 1 Nikko Chemicals * 2 Eisai * 3 Maruzen Pharmaceutical * 4 Maruzen Pharmaceutical * 5 Ajinomoto * 6 Nikko Chemicals * 7 Maruzen * 8 Manufactured in Production Example 1

(Manufacturing method)
A. Components (1) to (11) are mixed and dissolved.
B. Components (12) to (18) are mixed and dissolved.
C. B was added to A and mixed uniformly to obtain a skin lotion.

(Example 5) Cream (Ingredient) (%)
(1) Squalane 20.0
(2) Beeswax 5.0
(3) Jojoba oil 5.0
(4) Glyceryl monostearate 2.0
(5) Polyoxyethylene monostearate (20)
Sorbitan 2.0
(6) Sorbitan monostearate 2.0
(7) Phytosterol * 1 0.5
(8) Candelilla wax * 2 1.0
(9) Glycerin 5.0
(10) Methyl paraoxybenzoate 0.1
(11) Orchid extract * 3 1.0
(12) Mokutsu extract * 4 1.0
(13) Lily extract * 5 1.0
(14) Carrot extract * 6 1.0
(15) Ginkgo biloba extract * 7 1.0
(16) Gennoshoco extract * 8 1.0
(17) Isolate extract * 9 1.0
(18) Clara extract * 10 1.0
(19) Hydrolyzed rice extract * 11 1.0
(20) Licorice flavonoid * 12 1.0
(21) Toki extract * 13 1.0
(22) Rahan fruit water * 14 20.0
(23) Purified water Remaining amount (24) Fragrance Appropriate amount * 1 Made by Eisai * 2 Made by Noda Wax Co., Ltd. * 3 Made by Nagayodo Co., Ltd. * 4 Made by Nippon Oil & Fats Co., Ltd. * 5 Made by Maruzen Pharmaceutical Co., Ltd. * 6 Made by Maruzen Pharmaceutical Co., Ltd. * 7 Joban * 8 Maruzen Pharmaceutical * 10 Maruzen * 11 Technol * 12 Maruzen * 13 Nippon Powder Pharmaceutical * 14 Manufactured in Production Example 1 What

(Manufacturing method)
A. Ingredients (1) to (10) are heated and mixed and maintained at 70 ° C.
B. Ingredients (11) to (23) are heated and mixed and maintained at 70 ° C.
C. B is added to A and emulsified.
D. After cooling, component (24) was added to C to obtain a cream.

  Examples 4 and 5 have excellent stability over time, good spread, excellent moisturizing effect, improved skin dullness due to sunburn, improved rough skin and wrinkles due to drying, transparency It was a lotion and cream that could make beautiful skin.

(Example 6) Cleansing cream (ingredient) (%)
(1) Paraffin wax 10.0
(2) Beeswax 3.0
(3) Vaseline 15.0
(4) Liquid paraffin 41.0
(5) Sorbitan sesquioleate 4.2
(6) Polyoxyethylene monooleate (20)
Sorbitan 0.8
(7) Hydrogenated soybean phospholipid 0.5
(8) Medu home oil * 1 1.0
(9) Methyl paraoxybenzoate 0.1
(10) Quince seed extract * 2 1.0
(11) Ouren extract * 3 1.0
(12) Lily extract * 4 1.0
(13) Brown sugar extract * 5 1.0
(14) Hydrolyzed rice bran extract * 6 1.0
(15) Rakan fruit water * 7 10.0
(16) Purified water remaining amount (17) Perfume appropriate amount * 1 Made by Nippon Surfactant * 2 Made by Koei Kogyo * 3 Made by Maruzen Pharmaceutical * 4 Made by Maruzen Pharmaceutical * 5 Made by Taiyo Chemical * 6 Made by Technoble * 7 Produced in Production Example 1

(Manufacturing method)
A. Ingredients (1) to (9) are heated and mixed and maintained at 70 ° C.
B. Ingredients (10) to (16) are heated and mixed and maintained at 70 ° C.
C. Add B to A, mix and uniformly emulsify.
D. After cooling, component (17) was added to C to obtain a cleansing cream.

  Example 6 was a cleansing cream that was excellent in stability over time, was familiar with skin stains and makeup stains, had good stain removal, and could be used to make beautiful skin with transparency when used continuously.

(Example 7) Emulsion (Ingredient) (%)
(1) Sorbitan monostearate 0.3
(2) Polyoxyethylene monooleate (20)
Sorbitan 0.1
(3) Lipophilic glyceryl monostearate 0.2
(4) Stearic acid 0.5
(5) Cetanol 0.5
(6) Squalane 3.0
(7) Liquid paraffin 4.0
(8) Plant squalane * 1 0.2
(9) Glyceryl tri-2-ethylhexanoate 2.0
(10) Dimethylpolysiloxane 1.0
(11) Hydrogenated soybean phospholipid 0.1
(12) dl-α-tocopherol acetate * 2 0.05
(13) Ethyl paraoxybenzoate 0.1
(14) Carboxyvinyl polymer 0.1
(15) Sodium hydroxide 0.05
(16) Glycerin 5.0
(17) 1,3-butylene glycol 7.0
(18) Ethyl alcohol 5.0
(19) Fruit water of Rahan fruit * 3 Residual amount (20) Peonies extract * 4 3.0
(21) Orchid extract * 5 1.0
(22) Edelweiss extract * 6 1.0
(23) Mokutsu extract * 7 1.0
(24) Sodium dl-pyrrolidonecarboxylate * 8 0.2
(25) Porous silica 3.0
(26) Fragrance Appropriate amount * 1 Nikko Chemicals * 2 Eisai * 3 Manufactured in Production Example 1 * 4 Maruzen Pharmaceutical * 5 Nagasendo * 6 Pentafarm * 7 Nippon Oil & Fats * 8 Made by Ajinomoto Co.

(Manufacturing method)
A. Ingredients (1) to (13) are heated and mixed and maintained at 70 ° C.
B. Ingredients (14)-(24) are heated and mixed and maintained at 70 ° C.
C. Add B to A, mix and uniformly emulsify.
D. After cooling, components (25) and (26) were added to C to obtain an emulsion.

(Example 8) Emulsion (Ingredient) (%)
(1) Sorbitan monostearate 0.3
(2) Polyoxyethylene monooleate (20)
Sorbitan 0.1
(3) Lipophilic glyceryl monostearate 0.2
(4) Stearic acid 0.5
(5) Cetanol 0.5
(6) Squalane 3.0
(7) Liquid paraffin 4.0
(8) Glyceryl tri-2-ethylhexanoate 2.0
(9) Dimethylpolysiloxane 1.0
(10) Hydrogenated soybean phospholipid 0.1
(11) Rutin * 1 0.2
(12) Methyl paraoxybenzoate 0.1
(13) Carboxyvinyl polymer 0.1
(14) Sodium hydroxide 0.05
(15) Glycerin 5.0
(16) 1,3-butylene glycol 7.0
(17) Rakan fruit water * 2 50.0
(18) Purified water remaining amount (19) ethyl alcohol 5.0
(20) Yeast extract * 3 0.5
(21) Ganoderma extract * 4 0.5
(22) Hop extract * 5 0.5
(23) Peach extract * 6 0.5
(24) Porous silica 3.0
(25) Fragrance Appropriate amount * 1 Made by Sigma * 2 Made in Production Example 1 * 3 Made by BIO-DELL * 4 Made by Maruzen Pharmaceutical * 5 Made by Maruzen Pharmaceutical * 6 Made by Maruzen Pharmaceutical

(Manufacturing method)
A. Ingredients (1) to (12) are heated and mixed and maintained at 70 ° C.
B. Ingredients (13)-(23) are heated and mixed and maintained at 70 ° C.
C. Add B to A, mix and uniformly emulsify.
D. After cooling, components (24) and (25) were added to C to obtain an emulsion.

  Both Example 7 and Example 8 are excellent in stability over time, spread well and are not sticky, have an excellent moisturizing effect, improve skin dullness due to sunburn, and improve rough skin and fine lines due to drying. It was an emulsion that could make the skin beautiful and transparent.

(Example 9) Pack (Ingredient) (%)
(1) Polyvinyl alcohol 15.0
(2) Silicic anhydride 0.5
(3) Polyethylene glycol 0.5
(4) Medu home oil * 1 0.2
(5) Polyoxypropylene (10) methyl glucoside 5.0
(6) Glycerin 5.0
(7) Tea extract * 2 1.0
(8) Hermanus extract * 3 1.0
(9) Anhydrous caffeine * 4 1.0
(10) Rahan fruit water * 5 Residual amount (11) Ethyl alcohol 20.0
(12) Ethyl paraoxybenzoate 0.1
(13) Phosphate-L-ascorbyl magnesium * 6 3.0
* 1 Made by Nippon Surfactant * 2 Made by Maruzen Pharmaceutical * 3 Made by Maruzen Pharmaceutical * 4 Made by Pure Chemical Industries * 5 Made in Production Example 1 * 6 Made by Nikko Chemicals

(Manufacturing method)
A. Components (1) to (6) are mixed and heated to 70 ° C.
B. Components (7) to (13) are mixed and dissolved.
C. B was added to A, dissolved by heating, and cooled to obtain a pack.

(Example 10) Pack (Ingredient) (%)
(1) Polyvinyl alcohol 15.0
(2) Silicic anhydride 0.5
(3) Polyethylene glycol 0.5
(4) Polyoxypropylene (10) methyl glucoside 5.0
(5) Glycerin 5.0
(6) Fruit water of Rahan fruit * 1 Remaining amount (7) Rosemary water * 2 10.0
(8) Ethyl alcohol 20.0
(9) Ethyl paraoxybenzoate 0.1
(10) Yokuinin extract * 3 0.5
(11) Wheat extract * 4 0.5
(12) Sohakuhi extract * 5 0.5
(13) Crape myrtle extract * 6 0.5
(14) Fragrance Appropriate amount * 1 Produced in Production Example 1 * 2 Koei Kogyo Co., Ltd. * 3 Maruzen Pharmaceutical Co., Ltd. * 4 Seiwa Kasei Co., Ltd. * 5 Maruzen Pharmaceutical Co., Ltd. * 6 Maruzen Pharmaceutical Co., Ltd.

(Manufacturing method)
A. Components (1) to (5) are mixed and heated to 70 ° C.
B. Components (6) to (13) are mixed and dissolved.
C. B was added to A, dissolved by heating, cooled, and component (14) was added to obtain a pack.

  Example 9 and Example 10 were packs that were excellent in stability over time and, as a result of application to the skin, made the skin fresh, improved dullness of the skin, and made the skin beautiful and transparent.

(Example 11) Liquid foundation (ingredient) (%)
(1) Liquid lanolin 2.0
(2) Liquid paraffin 5.0
(3) Stearic acid 2.0
(4) Cetanol 1.0
(5) Self-emulsifying glyceryl monostearate 1.0
(6) Paramethoxycinnamic acid-2-ethylhexyl 8.0
(7) Methyl paraoxybenzoate 0.1
(8) Glycerin 5.0
(9) Triethanolamine 1.0
(10) Carboxymethylcellulose 0.2
(11) Bentonite 0.5
(12) Rakan fruit water * 1 10.0
(13) Purified water remaining amount (14) Titanium oxide 6.0
(15) Fine particle titanium oxide 2.0
(16) Fine zinc oxide 5.0
(17) Mica 2.0
(18) Talc 4.0
(19) Color pigment 4.0
(20) Licorice extract * 2 0.1
(21) Nicotinamide * 3 0.5
(22) Mannitol * 4 0.1
(23) Perfume Appropriate amount * 1 Made in Production Example 1 * 2 Made by Maruzen Pharmaceutical Co., Ltd. * 3 Made by Organic Synthetic Chemicals Co., Ltd. * 3 Made by Sigma

(Manufacturing method)
A. Components (1) to (7) are mixed and dissolved.
B. Ingredients (14) to (19) are added to A, mixed uniformly, and kept at 70 ° C.
C. Ingredients (8) to (13), (21), (22) are uniformly dissolved and maintained at 70 ° C.
D. B is added to C and emulsified uniformly.
E. After cooling D, components (20) and (23) were added to obtain a liquid foundation.

(Example 12) Liquid foundation (ingredient) (%)
(1) Liquid lanolin 2.0
(2) Liquid paraffin 5.0
(3) Stearic acid 2.0
(4) Cetanol 1.0
(5) Self-emulsifying glyceryl monostearate 1.0
(6) Paramethoxycinnamic acid-2-ethylhexyl 8.0
(7) 4-tert-butyl-4′-methoxy dibenzoylmethane 2.0
(8) Retinol palmitate * 1 0.2
(9) Methyl paraoxybenzoate 0.1
(10) Glycerin 5.0
(11) Triethanolamine 1.0
(12) Carboxymethylcellulose 0.2
(13) Bentonite 0.5
(14) Rahan fruit water * 2 Remaining amount (15) Titanium oxide 6.0
(16) Fine particle titanium oxide 2.0
(17) Fine zinc oxide 5.0
(18) Mica 2.0
(19) Talc 4.0
(20) Color pigment 4.0
(21) Phosphoric acid-L-ascorbyl magnesium * 3 0.3
(22) Asparagus extract * 4 0.5
(23) Yuzu extract * 5 0.5
(24) Fragrance appropriate amount * 1 Made by Nippon Roche * 2 Made in Production Example 1 * 3 Made by Nikko Chemicals * 4 Made by Maruzen Pharmaceutical * 5 Made by Maruzen Pharmaceutical

(Manufacturing method)
A. Components (1) to (9) are mixed and dissolved.
B. Ingredients (15) to (20) are added to A, mixed uniformly, and kept at 70 ° C.
C. Ingredients (10) to (14) and (21) are uniformly dissolved and maintained at 70 ° C.
D. B is added to C and emulsified uniformly.
E. After cooling D, components (22) to (24) were added to obtain a liquid foundation.

(Example 13) Cream foundation (Ingredient) (%)
(1) Sorbitan sesquioleate 3.0
(2) Self-emulsifying glyceryl monostearate 2.0
(3) Aluminum stearate 0.5
(4) Ceresin wax 5.0
(5) Squalane 10.0
(6) Liquid paraffin 15.0
(7) Vaseline 5.0
(8) Titanium oxide 8.0
(9) Talc 4.0
(10) Coloring pigment appropriate amount (11) Methyl paraoxybenzoate 0.05
(12) Propylene glycol 5.0
(13) Kinginga extract * 1 1.0
(14) Birch extract * 2 1.0
(15) Ginkgo biloba extract * 3 1.0
(16) Maronnier extract * 4 1.0
(17) Rahan fruit water * 5 5.0
(18) Purified water Remaining amount (19) Fragrance Appropriate amount * 1 Made by Nagaoka Fragrance Co., Ltd. * 2 Made by Maruzen Pharmaceutical Co., Ltd. * 3 Made by Tokiwa Plant Chemistry Laboratories * 4 Made by Koei Kogyo Co., Ltd.

(Manufacturing method)
A. Ingredients (1) to (11) are heated and mixed and maintained at 70 ° C.
B. Ingredients (12)-(18) are heated and mixed and maintained at 70 ° C.
C. Add B to A, mix and uniformly emulsify.
D. After cooling, component (19) was added to C to obtain a cream foundation.

  Examples 11 to 13 are liquid foundations that are excellent in stability over time, have excellent makeup effects when applied to the skin, prevent skin dullness, spots and freckles due to sunburn, and can make the skin beautiful and transparent. It was a cream foundation.

(Example 14) Sunscreen emulsion (component) (%)
(1) Polyoxyalkylene-modified organopolysiloxane 1.0
(2) Dimethylpolysiloxane 5.0
(3) Octamethylcyclotetrasiloxane 20.0
(4) Isotridecyl isononanoate 5.0
(5) Paramethoxycinnamic acid-2-ethylhexyl 5.0
(6) Methyl paraoxybenzoate 0.1
(7) Silicone-treated fine particle titanium oxide 10.0
(8) Silicone-treated fine particle zinc oxide 10.0
(9) Polystyrene powder 3.0
(10) Trimethylsiloxysilicate 0.5
(11) Dipropylene glycol 3.0
(12) Ethyl alcohol 10.0
(13) Rakan fruit water * 1 Remaining amount (14) Salt 0.2
(15) β-carotene * 2 0.01
(16) Chamomile extract * 3 1.0
(17) Warmoko extract * 4 1.0
(18) Fragrance Appropriate amount * 1 Made in Production Example 1 * 2 Sankyo Pharmaceutical Co., Ltd. * 3 Maruzen Pharmaceutical Co., Ltd. * 4 Maruzen Pharmaceutical Co., Ltd.

(Manufacturing method)
A. Ingredients (1) to (10) are mixed and kept at 70 ° C.
B. Ingredients (11)-(14) are mixed and kept at 70 ° C.
C. Add B to A and emulsify uniformly.
D. After cooling, components (15) to (18) were added to C to obtain a sunscreen emulsion.

(Example 15) Sunscreen emulsion (Ingredient) (%)
(1) Polyoxyalkylene-modified organopolysiloxane 1.0
(2) Dimethylpolysiloxane 5.0
(3) Octamethylcyclotetrasiloxane 20.0
(4) Isotridecyl isononanoate 5.0
(5) Paramethoxycinnamic acid-2-ethylhexyl 10.0
(6) Methyl paraoxybenzoate 0.1
(7) Silicone-treated fine particle titanium oxide 8.0
(8) Silicone-treated fine particle zinc oxide 7.0
(9) Polystyrene powder 3.0
(10) Trimethylsiloxysilicate 0.5
(11) Dipropylene glycol 3.0
(12) Ethyl alcohol 10.0
(13) Rahan fruit water * 1 5.0
(14) Purified water remaining amount (15) Salt 0.2
(16) Daylily extract * 2 1.0
(17) Green tea extract * 3 0.5
(18) Aloe extract * 4 0.5
(19) Fragrance Appropriate amount * 1 Produced in Production Example 1 * 2 Made by Maruzen Pharmaceutical * 3 Made by Maruzen Pharmaceutical * 4 Made by Maruzen Pharmaceutical

(Manufacturing method)
A. Ingredients (1) to (10) are mixed and kept at 70 ° C.
B. Ingredients (11)-(18) are mixed and kept at 70 ° C.
C. Add B to A and emulsify uniformly.
D. After cooling, component (19) was added to C to obtain a sunscreen emulsion.

  Examples 14 and 15 were sunscreen emulsions that were excellent in stability over time, lightly stretched and non-sticky, and excellent in the effects of preventing skin darkening and spots and freckles due to sunburn.

It is a figure which shows the change of the moisture content after a lotion application | coating. (Test Example 2)

Claims (5)

A skin external preparation characterized by containing an aqueous layer part obtained by filtering a pressed fruit juice of Rakan fruit with a nano filter. The skin external preparation according to claim 1, comprising an aqueous layer part obtained by filtering the pressed fruit juice of Rakan fruit with a nano filter as a beautifying skin component. The skin external preparation according to claim 1, comprising a water layer portion obtained by filtering the pressed fruit juice of Rakan fruit with a nano filter as a moisturizing component. The skin external preparation for beautiful skin according to claim 1 or 2, comprising a water layer portion obtained by filtering the pressed fruit juice of Rakan fruit with a nano filter. The skin external preparation for anti-aging according to claim 1 or 3, comprising an aqueous layer part obtained by filtering the pressed fruit juice of Rakan fruit with a nano filter.