JP2009057309A - Skin preparation for external use and humectant - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a humectant exhibiting a high moisturizing effect and a skin preparation for external use. <P>SOLUTION: This skin preparation for external use comprises an extract of Hosta rectifolia nakai as an active ingredient, and the humectant comprises the extract of the H. rectifolia nakai as the active ingredient. <P>COPYRIGHT: (C)2009,JPO&INPIT

Description

  The present invention relates to a skin external preparation and a moisturizing agent that exhibit a high moisturizing effect.

It is known that the amount of moisture in the skin stratum corneum is closely related to the maintenance of skin health and the defense function against various external stimuli, and plays a major role in the feel of skin moisture and smoothness. . Moisture retention of this stratum corneum is usually controlled by natural moisturizing factor (NMF) and sebum membrane, but its function is easily degraded by external stimuli, so a moisturizing agent should be added to the topical skin preparation. Is generally done.
As moisturizers, polyhydric alcohols, natural polymers, NMF components, etc. are generally used, but plant extract components also supplement the stratum corneum's moisturizing function to create moisturized skin, Widely formulated because it is effective in maintaining homeostasis.
As such plant components, the use as a moisturizing agent has been studied for many plants such as Fussa family (Patent Document 1) and Angiosperm genus plant (Patent Document 2).

JP 2007-084443 A JP 2007-106741 A

  Naturally-derived components are known to have various pharmacological and cosmetic effects, and so far many plants and fungi have been widely applied to fields such as external preparations for skin and foods and drinks. However, there are many naturally-derived components whose effects are not yet known, and the development of a moisturizing agent having an excellent moisturizing action has been expected. The present invention has been made to find such an effective moisturizing agent, and an object thereof is to provide a moisturizing agent that can be applied to an external preparation for skin.

  In order to find a moisturizing agent that can be applied to an external preparation for skin, the present inventors have studied various naturally occurring plants. As a result, an excellent moisturizing effect was found in the extract of the prickly cattle, and further studies were made to complete the present invention. That is, the present invention provides an external preparation for skin containing an extract of a spotted bovine as an active ingredient, and a moisturizer containing an extract of a spotted bovine as an active ingredient.

  ADVANTAGE OF THE INVENTION According to this invention, the moisturizing agent and skin external preparation which have the outstanding moisturizing effect can be provided.

Is a plant used as the raw material of the present invention Tachigiboushi (Hosta rectifolia Nakai: Hosta siebordii) is a herbaceous belonging to Liliaceae Hosta genus, Honshu from Hokkaido, distributed widely Kyushu. In the present invention, the active body or the dried product may be used for the prickly cattle, but it is preferable to use extracts extracted using various solvents. Any part of the stem, leaves, flowers, seeds, roots, rhizomes, fruits, buds, and the like may be used for extraction, but whole plants may be used in terms of effectiveness. In the extraction, the raw material may be used as it is. However, in consideration of the extraction efficiency, it is preferable to perform the extraction after performing processing such as shredding, drying, and pulverization. The extraction can be performed by immersing in an extraction solvent or by an extraction method using a supercritical fluid or a subcritical fluid. In order to increase the extraction efficiency, homogenization may be performed in stirring or an extraction solvent. The extraction temperature is suitably about 5 ° C. to the boiling point of the extraction solvent. The extraction time varies depending on the type of extraction solvent and the extraction temperature, but it is appropriate to set it to about 1 hour to 14 days.

  Extraction solvents include water, lower alcohols such as methanol, ethanol, propanol and isopropanol, polyhydric alcohols such as 1,3-butylene glycol, propylene glycol, dipropylene glycol and glycerin, ethers such as ethyl ether and propyl ether. , Solvents such as esters such as butyl acetate and ethyl acetate, and ketones such as acetone and ethyl methyl ketone can be used, and one or more of these can be selected and used. Further, physiological saline, phosphate buffer, phosphate buffered saline, or the like may be used. Furthermore, you may use 1 type, or 2 or more types of supercritical fluids and subcritical fluids, such as water, a carbon dioxide, ethylene, propylene, ethanol, methanol, ammonia.

  The extract of the above-mentioned solvent of the prickly cattle can be used as it is, but the concentrated and dried product can be used again by dissolving it in water or a polar solvent, and it is decolorized as long as these physiological functions are not impaired. Alternatively, it may be used after purification treatment such as deodorization or desalting, or fractionation treatment by column chromatography or the like. The above extract of Tachigiboushi and its processed products and fractions can be freeze-dried after each treatment and fractionation and dissolved in a solvent at the time of use.

  The extract of Tachigiboushi has an excellent moisturizing action and can be used as a moisturizer containing the extract of Tachigiboushi as an active ingredient.

  The blending amount of the extract of the prickly bovine into the skin external preparation can be adjusted depending on the type of skin external preparation, the purpose of use, etc., but it is 0.0001 based on the total amount from the viewpoint of the effect and stability. -50.0 mass% is preferable, More preferably, it is 0.001-25.0 mass%.

  The dosage form of the external preparation for skin to which the extract of the guinea pig is blended is arbitrary, and can be provided as, for example, a solubilizing system such as lotion, an emulsifying system such as cream or emulsion, and a dispersing system such as calamine lotion. Furthermore, it can also be provided in various dosage forms such as aerosols, ointments, powders and granules filled with a propellant.

  It should be noted that the topical skin preparation containing the Tachigiboushi extract is usually blended with pharmaceuticals, quasi-drugs, skin cosmetics, hair cosmetics, and cleansing agents as needed in addition to the Tachigibo extract. Oily ingredients, moisturizers, powders, pigments, emulsifiers, solubilizers, detergents, UV absorbers, thickeners, drugs, fragrances, resins, antibacterial and antifungal agents, alcohols, etc. Can do. Moreover, in the range which does not impair the effect of this invention, combined use with another moisturizer, a cell activator, or an antioxidant is also possible.

  In the following, the production example of the Tachigiboushi extract, the test for evaluating each action, the formulation example of the external preparation for skin, and the use test will be described in more detail, but the technical scope of the present invention is not limited thereby. Absent.

[Extract 1]
100 g of the dry ground pulverized material of the ground plant including stems, buds, flowers, and sprouts of the prickly cattle was heat extracted with 2.0 kg of hot water for 20 minutes. The extract supernatant was filtered and lyophilized to obtain extract 1.

[Extract 2]
100 g of a dry pulverized product of whole ground plant including stems, buds, flowers, and sprouts of the prickly cattle was dispersed in 2.0 kg of 50 vol% ethanol aqueous solution and extracted at room temperature for 2 hours with stirring. The extract supernatant was filtered off, concentrated under reduced pressure, and lyophilized to obtain extract 2.

[Extract 3]
A dry pulverized product of whole ground plant including stems, buds, flowers, and shoots of prickly cattle is put into a pressure cell, and liquefied carbon dioxide is continuously poured in by a pump, and it is left as it is under conditions of 25 MPa, 5 mL / min, and 40 ° C. Carbon dioxide was allowed to flow, and the extract components were collected in a gas-liquid separator to obtain an extract.

[Measurement of moisturizing effect]
Moisturizing effect was measured using 1% by weight aqueous solution of Extract 1 or Extract 2 as Example 1 or Example 2, and purified water as a comparative example. For the moisturizing effect, 24 μL of each of Examples 1 and 2 or Comparative Example was applied to the forearm portion and 3 × 4 cm ^{2 in} a range of 30 μm, and the keratin moisture content was measured before, 30 and 60 minutes after application. The horny water content was measured by using SKICON-200 (manufactured by IBI S Co., Ltd.), and the horny water content at 5 points from each application site was measured. Table 1 shows the relative values with the average value of the five-point measurement values as the keratin water content and the keratin water content before application as 1. After 15 minutes, 30 minutes, 60 minutes, and 120 minutes, the stratum corneum water content was tested for a significant difference between Comparative Example and Example 1, and Comparative Example and Example 2, with a significant difference of 5%. The results are shown in Table 1 as “*” for those with a significant difference and “**” for those with a significant difference with a probability of 1%.

  As shown in Table 1, the examples of the present invention all show a high moisturizing effect from 15 minutes to 120 minutes after application, and it is clear that the Tachigiboushi extract exhibits a high moisturizing effect.

  The formulation example of the skin external preparation which mix | blended the guinea pig extract is shown.

[Formulation Example 1] Emulsion (1) Squalane 10.0 (mass%)
(2) Methylphenylpolysiloxane 4.0
(3) Hydrogenated palm kernel oil 0.5
(4) Hydrogenated soybean phospholipid 0.1
(5) Polyoxyethylene monostearate
Sorbitan (20E.O.) 1.3
(6) Sorbitan monostearate 1.0
(7) Glycerin 4.0
(8) Methyl paraoxybenzoate 0.1
(9) Carboxyvinyl polymer 0.15
(10) Purified water 53.85
(11) Arginine (1% by weight aqueous solution) 20.0
(12) Extract 2 5.0
Production method: The oil phase components (1) to (6) are heated and dissolved at 80 ° C. On the other hand, the aqueous phase components (7) to (10) are dissolved by heating at 80 ° C. The oil phase component is added to this while stirring and uniformly emulsified with a homogenizer. After emulsification, start cooling and add (11) and (12) sequentially and mix uniformly.

[Prescription Example 2] Lotion (1) Ethanol 15.0 (mass%)
(2) Polyoxyethylene (40E.O.) hydrogenated castor oil 0.3
(3) Fragrance 0.1
(4) Purified water 78.38
(5) Citric acid 0.02
(6) Sodium citrate 0.1
(7) Glycerin 1.0
(8) Hydroxyethyl cellulose 0.1
(9) Extract 1 5.0
Production method: (2) and (3) are dissolved in (1). After dissolution, (4) to (8) are sequentially added, and then sufficiently stirred, (9) is added and mixed uniformly.

[Prescription Example 3] Cream (1) Squalane 10.0 (mass%)
(2) Stearic acid 2.0
(3) Hydrogenated palm kernel oil 0.5
(4) Hydrogenated soybean phospholipid 0.1
(5) Cetanol 3.6
(6) Lipophilic glyceryl monostearate 2.0
(7) Glycerin 10.0
(8) Methyl paraoxybenzoate 0.1
(9) Arginine (20 mass% aqueous solution) 15.0
(10) Purified water 40.7
(11) Carboxyvinyl polymer (1% by weight aqueous solution) 15.0
(12) Extract 2 1.0
Production method: The oil phase components (1) to (6) are heated and dissolved at 80 ° C. On the other hand, the aqueous phase components (7) to (10) are dissolved by heating at 80 ° C. The oil phase component is added to this while stirring and uniformly emulsified with a homogenizer. After the emulsification is completed, add (11), start cooling, add (12) at 40 ° C., and mix uniformly.

[Formulation Example 4] Cosmetic liquid (1) Purified water 27.45 (mass%)
(2) Glycerin 10.0
(3) Sucrose fatty acid ester 1.3
(4) Carboxyvinyl polymer (1% by weight aqueous solution) 17.5
(5) Sodium alginate (1% by weight aqueous solution) 15.0
(6) Polyglyceryl monolaurate 1.0
(7) Macadamia nut oil fatty acid phytosteryl 3.0
(8) N-lauroyl-L-glutamic acid di (phytosteryl-2-octyldodecyl) 2.0
(9) Hardened palm oil 2.0
(10) Squalane (from olive) 1.0
(11) Behenyl alcohol 0.75
(12) Beeswax 1.0
(13) Jojoba oil 1.0
(14) 1,3-butylene glycol 10.0
(15) L-arginine (10% by mass aqueous solution) 2.0
(16) Extract 2 5.0
Production method: The aqueous phase components (1) to (6) are mixed and dissolved by heating at 75 ° C. On the other hand, the oil phase components (7) to (14) are mixed and dissolved by heating at 75 ° C. Next, the oil phase component is added to the aqueous phase component and preliminary emulsification is performed, followed by uniform emulsification with a homomixer. Cooling is started after emulsification, and (15) is added at 50 ° C. Cool further to 40 ° C, add (16) and mix evenly.

[Formulation Example 5] Aqueous gel (1) Carboxyvinyl polymer 0.5 (mass%)
(2) Purified water 86.7
(3) Sodium hydroxide (10% by mass aqueous solution) 0.5
(4) Ethanol 10.0
(5) Methyl paraoxybenzoate 0.1
(6) Fragrance 0.1
(7) Extract 1 2.0
(8) Polyoxyethylene (60E.O.) hydrogenated castor oil 0.1
Manufacturing method: (1) is added to (2), and after stirring uniformly, (3) is added. After stirring uniformly, (5) previously dissolved in (4) is added. After stirring uniformly, the previously mixed (6) to (8) are added and stirred and mixed uniformly.

[Formulation Example 6] Cleansing Fee (1) Squalane 81.0 (mass%)
(2) Polyoxyethylene glyceryl isostearate 15.0
(3) Purified water 3.0
(4) Extract 3 1.0
Manufacturing method: (1) and (2) are uniformly dissolved. (3) and (4) are sequentially added to this and mixed uniformly.

[Formulation Example 7] Face-wash foam (1) Stearic acid 16.0 (mass%)
(2) Myristic acid 16.0
(3) Lipophilic glyceryl monostearate 2.0
(4) Glycerin 20.0
(5) Sodium hydroxide 7.5
(6) Palm oil fatty acid amidopropyl betaine 1.0
(7) Purified water 36.5
(8) Extract 1 1.0
Production method: The oil phase components (1) to (4) are heated and dissolved at 80 ° C. On the other hand, the aqueous phase components (5) to (7) are heated and dissolved at 80 ° C., and mixed and stirred uniformly with the oil phase components. Cooling is started, and (8) is added at 40 ° C. and mixed uniformly.

[Prescription Example 8] Make-up base cream (1) Squalane 10.0 (mass%)
(2) Cetanol 2.0
(3) Glycerin tri-2-ethylhexanoate 2.5
(4) Lipophilic glyceryl monostearate 1.0
(5) Propylene glycol 11.0
(6) Sucrose fatty acid ester 1.3
(7) Purified water 69.4
(8) Titanium oxide 1.0
(9) Bengala 0.1
(10) Yellow iron oxide 0.4
(11) Fragrance 0.1
(12) Extract 2 1.2
Production method: The oil phase components (1) to (4) are mixed and dissolved by heating at 75 ° C. On the other hand, the aqueous phase components (5) to (7) are mixed and dissolved by heating at 75 ° C., and the pigments (8) to (10) are added thereto and dispersed uniformly with a homomixer. The oil phase component is added to the water phase component and emulsified with a homomixer. Cooling is started after the emulsification is completed, and the components (11) and (12) are added at 40 ° C. and mixed uniformly.

[Prescription Example 9] Emulsion foundation (1) Methylpolysiloxane 2.0 (mass%)
(2) Squalane 5.0
(3) Octyldodecyl myristate 5.0
(4) Cetanol 1.0
(5) Polyoxyethylene (20E.O.)
Sorbitan monostearate 1.3
(6) Sorbitan monostearate 0.7
(7) 1,3-butylene glycol 8.0
(8) Xanthan gum 0.1
(9) Methyl paraoxybenzoate 0.1
(10) Purified water 57.4
(11) Titanium oxide 9.0
(12) Talc 7.4
(13) Bengala 0.5
(14) Yellow iron oxide 1.1
(15) Black iron oxide 0.1
(16) Fragrance 0.1
(17) Extract 1 1.0
Production method: The oil phase components (1) to (6) are mixed and dissolved by heating at 75 ° C. On the other hand, the aqueous phase components (7) to (10) are mixed and dissolved by heating at 75 ° C., and the pigments (11) to (15) are added thereto and uniformly dispersed with a homomixer. Add oil phase ingredients and emulsify. Cooling is started after the emulsification is completed, and components (16) and (17) are sequentially added at 40 ° C. and mixed uniformly.

[Formulation Example 10] Water-in-oil emollient cream (1) Liquid paraffin 30.0 (% by mass)
(2) Microcrystalline wax 2.0
(3) Vaseline 5.0
(4) Diglycerin oleate 5.0
(5) Sodium chloride 1.3
(6) Potassium chloride 0.1
(7) Propylene glycol 3.0
(8) 1,3-butylene glycol 5.0
(9) Methyl paraoxybenzoate 0.1
(10) Extract 2 1.0
(11) Purified water 47.4
(12) Fragrance 0.1
Production method: Dissolve (5) and (6) in a part of (11) to 50 ° C., and gradually add to (4) heated to 50 ° C. with stirring. After mixing this, it disperse | distributes uniformly to (1)-(3) heated and melt | dissolved at 70 degreeC. (7) to (10) are added to the remainder of (11) heated and dissolved at 70 ° C. while stirring and emulsified with a homomixer. Cooling is started after completion of emulsification, and (12) is added at 40 ° C. and mixed uniformly.

[Prescription Example 11] Pack (1) Purified water 58.9 (mass%)
(2) Polyvinyl alcohol 12.0
(3) Ethanol 17.0
(4) Glycerin 5.0
(5) Polyethylene glycol (average molecular weight 1000) 2.0
(6) Extract 1 5.0
(7) Fragrance 0.1
Production method: (2) and (3) are mixed, heated to 80 ° C, and then dissolved in (1) heated to 80 ° C. After uniformly dissolving, add (4) and (5), and start cooling while stirring. Cool to 40 ° C, add (6) and (7) and mix uniformly.

[Prescription Example 12] Bath agent (1) Fragrance 0.3 (% by mass)
(2) Extract 1 1.0
(3) Sodium bicarbonate 50.0
(4) Sodium sulfate 48.7
Production method: (1) to (4) are mixed uniformly.

Claims (2)

A topical skin preparation containing a Tachigiboushi extract. A moisturizing agent containing a Tachigiboushi extract as an active ingredient.