CN114983887A - Beautiful and light herbal liquid - Google Patents
Beautiful and light herbal liquid Download PDFInfo
- Publication number
- CN114983887A CN114983887A CN202210601371.XA CN202210601371A CN114983887A CN 114983887 A CN114983887 A CN 114983887A CN 202210601371 A CN202210601371 A CN 202210601371A CN 114983887 A CN114983887 A CN 114983887A
- Authority
- CN
- China
- Prior art keywords
- composition
- extract
- skin
- maltodextrin
- citric acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000007788 liquid Substances 0.000 title claims abstract description 32
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 105
- 239000000284 extract Substances 0.000 claims abstract description 43
- 239000005913 Maltodextrin Substances 0.000 claims abstract description 36
- 229920002774 Maltodextrin Polymers 0.000 claims abstract description 36
- 229940035034 maltodextrin Drugs 0.000 claims abstract description 36
- 229940119217 chamomile extract Drugs 0.000 claims abstract description 33
- 235000020221 chamomile extract Nutrition 0.000 claims abstract description 33
- 230000000694 effects Effects 0.000 claims abstract description 21
- 240000008632 Cota tinctoria Species 0.000 claims abstract description 19
- 230000004060 metabolic process Effects 0.000 claims abstract description 12
- 230000001737 promoting effect Effects 0.000 claims abstract description 11
- FFRBMBIXVSCUFS-UHFFFAOYSA-N 2,4-dinitro-1-naphthol Chemical compound C1=CC=C2C(O)=C([N+]([O-])=O)C=C([N+]([O-])=O)C2=C1 FFRBMBIXVSCUFS-UHFFFAOYSA-N 0.000 claims abstract description 6
- 239000000203 mixture Substances 0.000 claims description 81
- 241000555712 Forsythia Species 0.000 claims description 24
- 238000000034 method Methods 0.000 claims description 17
- 239000002537 cosmetic Substances 0.000 claims description 12
- 238000002360 preparation method Methods 0.000 claims description 7
- 241000576429 Forsythia suspensa Species 0.000 claims description 6
- 230000003796 beauty Effects 0.000 claims description 6
- 239000008194 pharmaceutical composition Substances 0.000 claims description 6
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract description 8
- 238000002485 combustion reaction Methods 0.000 abstract description 6
- 239000002699 waste material Substances 0.000 abstract description 6
- 210000002249 digestive system Anatomy 0.000 abstract description 5
- 230000002708 enhancing effect Effects 0.000 abstract description 5
- 230000009286 beneficial effect Effects 0.000 abstract description 4
- 230000008030 elimination Effects 0.000 abstract description 4
- 238000003379 elimination reaction Methods 0.000 abstract description 4
- 239000003925 fat Substances 0.000 description 19
- 235000019197 fats Nutrition 0.000 description 19
- -1 lauryl methyl Chemical group 0.000 description 14
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 13
- 239000004615 ingredient Substances 0.000 description 11
- 239000003921 oil Substances 0.000 description 11
- 235000019198 oils Nutrition 0.000 description 11
- 238000012360 testing method Methods 0.000 description 10
- KIUVQMGRTDPAFR-UHFFFAOYSA-N benzoic acid 2-hydroxy-2-phenylpropanamide Chemical compound C(C1=CC=CC=C1)(=O)O.OC(C(=O)N)(C)C1=CC=CC=C1 KIUVQMGRTDPAFR-UHFFFAOYSA-N 0.000 description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
- 230000002195 synergetic effect Effects 0.000 description 7
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 6
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 description 6
- 230000008859 change Effects 0.000 description 6
- 235000014113 dietary fatty acids Nutrition 0.000 description 6
- 239000003814 drug Substances 0.000 description 6
- 239000000194 fatty acid Substances 0.000 description 6
- 229930195729 fatty acid Natural products 0.000 description 6
- 238000003756 stirring Methods 0.000 description 6
- 239000004094 surface-active agent Substances 0.000 description 6
- 229920002125 Sokalan® Polymers 0.000 description 5
- 229960001631 carbomer Drugs 0.000 description 5
- 230000001276 controlling effect Effects 0.000 description 5
- 235000011187 glycerol Nutrition 0.000 description 5
- 230000009467 reduction Effects 0.000 description 5
- 210000004003 subcutaneous fat Anatomy 0.000 description 5
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 4
- 239000004698 Polyethylene Substances 0.000 description 4
- 239000004480 active ingredient Substances 0.000 description 4
- 230000000875 corresponding effect Effects 0.000 description 4
- 230000006378 damage Effects 0.000 description 4
- 235000005911 diet Nutrition 0.000 description 4
- 230000037213 diet Effects 0.000 description 4
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 4
- 229920000573 polyethylene Polymers 0.000 description 4
- 239000003755 preservative agent Substances 0.000 description 4
- 229910052708 sodium Inorganic materials 0.000 description 4
- 239000011734 sodium Substances 0.000 description 4
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 208000008589 Obesity Diseases 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 210000001015 abdomen Anatomy 0.000 description 3
- 229960000458 allantoin Drugs 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 230000037396 body weight Effects 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 239000003974 emollient agent Substances 0.000 description 3
- 230000001804 emulsifying effect Effects 0.000 description 3
- 150000004665 fatty acids Chemical class 0.000 description 3
- 229930182478 glucoside Natural products 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 230000002757 inflammatory effect Effects 0.000 description 3
- 235000020824 obesity Nutrition 0.000 description 3
- 230000002335 preservative effect Effects 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 239000000523 sample Substances 0.000 description 3
- 230000028327 secretion Effects 0.000 description 3
- 210000000689 upper leg Anatomy 0.000 description 3
- 239000003981 vehicle Substances 0.000 description 3
- BANXPJUEBPWEOT-UHFFFAOYSA-N 2-methyl-Pentadecane Chemical compound CCCCCCCCCCCCCC(C)C BANXPJUEBPWEOT-UHFFFAOYSA-N 0.000 description 2
- WRMNZCZEMHIOCP-UHFFFAOYSA-N 2-phenylethanol Chemical compound OCCC1=CC=CC=C1 WRMNZCZEMHIOCP-UHFFFAOYSA-N 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 206010012735 Diarrhoea Diseases 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 206010015150 Erythema Diseases 0.000 description 2
- 241000628997 Flos Species 0.000 description 2
- 208000002720 Malnutrition Diseases 0.000 description 2
- 239000004909 Moisturizer Substances 0.000 description 2
- 108010020346 Polyglutamic Acid Proteins 0.000 description 2
- 208000003251 Pruritus Diseases 0.000 description 2
- VYGQUTWHTHXGQB-FFHKNEKCSA-N Retinol Palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C VYGQUTWHTHXGQB-FFHKNEKCSA-N 0.000 description 2
- 206010058679 Skin oedema Diseases 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 230000001387 anti-histamine Effects 0.000 description 2
- 230000001139 anti-pruritic effect Effects 0.000 description 2
- 239000000739 antihistaminic agent Substances 0.000 description 2
- 230000036528 appetite Effects 0.000 description 2
- 235000019789 appetite Nutrition 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 229960004106 citric acid Drugs 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 239000003995 emulsifying agent Substances 0.000 description 2
- SHZIWNPUGXLXDT-UHFFFAOYSA-N ethyl hexanoate Chemical compound CCCCCC(=O)OCC SHZIWNPUGXLXDT-UHFFFAOYSA-N 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 229920000370 gamma-poly(glutamate) polymer Polymers 0.000 description 2
- 150000008131 glucosides Chemical class 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 2
- 229960001340 histamine Drugs 0.000 description 2
- BJRNKVDFDLYUGJ-RMPHRYRLSA-N hydroquinone O-beta-D-glucopyranoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-RMPHRYRLSA-N 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 230000001965 increasing effect Effects 0.000 description 2
- 239000002085 irritant Substances 0.000 description 2
- 230000000622 irritating effect Effects 0.000 description 2
- 230000001071 malnutrition Effects 0.000 description 2
- 235000000824 malnutrition Nutrition 0.000 description 2
- 230000001333 moisturizer Effects 0.000 description 2
- SZUJJDLBXJCDNT-ZCNNSNEGSA-N n-[(2s,3s,4r)-1,3,4-trihydroxyoctadecan-2-yl]acetamide Chemical compound CCCCCCCCCCCCCC[C@@H](O)[C@@H](O)[C@H](CO)NC(C)=O SZUJJDLBXJCDNT-ZCNNSNEGSA-N 0.000 description 2
- 208000015380 nutritional deficiency disease Diseases 0.000 description 2
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 2
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 2
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000005720 sucrose Substances 0.000 description 2
- 230000001502 supplementing effect Effects 0.000 description 2
- HLZKNKRTKFSKGZ-UHFFFAOYSA-N tetradecan-1-ol Chemical compound CCCCCCCCCCCCCCO HLZKNKRTKFSKGZ-UHFFFAOYSA-N 0.000 description 2
- 239000002562 thickening agent Substances 0.000 description 2
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 2
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical group OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 2
- 229960000281 trometamol Drugs 0.000 description 2
- 238000012795 verification Methods 0.000 description 2
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 1
- WTVHAMTYZJGJLJ-UHFFFAOYSA-N (+)-(4S,8R)-8-epi-beta-bisabolol Natural products CC(C)=CCCC(C)C1(O)CCC(C)=CC1 WTVHAMTYZJGJLJ-UHFFFAOYSA-N 0.000 description 1
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 1
- RGZSQWQPBWRIAQ-CABCVRRESA-N (-)-alpha-Bisabolol Chemical compound CC(C)=CCC[C@](C)(O)[C@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-CABCVRRESA-N 0.000 description 1
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 1
- WQKLGQXWHKQTPO-UXRZSMILSA-N (2r,3s,4s,5r,6r)-2-(hydroxymethyl)-6-methoxyoxane-3,4,5-triol;2-(2-hydroxypropoxy)propan-1-ol Chemical compound CC(O)COC(C)CO.CC(O)COC(C)CO.CC(O)COC(C)CO.CC(O)COC(C)CO.CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O WQKLGQXWHKQTPO-UXRZSMILSA-N 0.000 description 1
- KZRXPHCVIMWWDS-AWEZNQCLSA-N (4S)-4-amino-5-dodecanoyloxy-5-oxopentanoic acid Chemical compound CCCCCCCCCCCC(=O)OC(=O)[C@@H](N)CCC(O)=O KZRXPHCVIMWWDS-AWEZNQCLSA-N 0.000 description 1
- MXOAEAUPQDYUQM-QMMMGPOBSA-N (S)-chlorphenesin Chemical compound OC[C@H](O)COC1=CC=C(Cl)C=C1 MXOAEAUPQDYUQM-QMMMGPOBSA-N 0.000 description 1
- ZORQXIQZAOLNGE-UHFFFAOYSA-N 1,1-difluorocyclohexane Chemical compound FC1(F)CCCCC1 ZORQXIQZAOLNGE-UHFFFAOYSA-N 0.000 description 1
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 1
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical class CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
- 229940043268 2,2,4,4,6,8,8-heptamethylnonane Drugs 0.000 description 1
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 description 1
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 1
- XPALGXXLALUMLE-UHFFFAOYSA-N 2-(dimethylamino)tetradecanoic acid Chemical compound CCCCCCCCCCCCC(N(C)C)C(O)=O XPALGXXLALUMLE-UHFFFAOYSA-N 0.000 description 1
- UITSPQLTFPTHJZ-UHFFFAOYSA-N 2-[[3,4,5-tris(2-hydroxyethoxy)-6-methoxyoxan-2-yl]methoxy]ethanol Chemical compound COC1OC(COCCO)C(OCCO)C(OCCO)C1OCCO UITSPQLTFPTHJZ-UHFFFAOYSA-N 0.000 description 1
- WSSJONWNBBTCMG-UHFFFAOYSA-N 2-hydroxybenzoic acid (3,3,5-trimethylcyclohexyl) ester Chemical compound C1C(C)(C)CC(C)CC1OC(=O)C1=CC=CC=C1O WSSJONWNBBTCMG-UHFFFAOYSA-N 0.000 description 1
- ICIDSZQHPUZUHC-UHFFFAOYSA-N 2-octadecoxyethanol Chemical compound CCCCCCCCCCCCCCCCCCOCCO ICIDSZQHPUZUHC-UHFFFAOYSA-N 0.000 description 1
- LEACJMVNYZDSKR-UHFFFAOYSA-N 2-octyldodecan-1-ol Chemical compound CCCCCCCCCCC(CO)CCCCCCCC LEACJMVNYZDSKR-UHFFFAOYSA-N 0.000 description 1
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 description 1
- RMTFNDVZYPHUEF-XZBKPIIZSA-N 3-O-methyl-D-glucose Chemical compound O=C[C@H](O)[C@@H](OC)[C@H](O)[C@H](O)CO RMTFNDVZYPHUEF-XZBKPIIZSA-N 0.000 description 1
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 description 1
- XZIIFPSPUDAGJM-UHFFFAOYSA-N 6-chloro-2-n,2-n-diethylpyrimidine-2,4-diamine Chemical compound CCN(CC)C1=NC(N)=CC(Cl)=N1 XZIIFPSPUDAGJM-UHFFFAOYSA-N 0.000 description 1
- 208000002874 Acne Vulgaris Diseases 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 1
- 241000454552 Astrocaryum murumuru Species 0.000 description 1
- 241001530056 Athelia rolfsii Species 0.000 description 1
- 208000008035 Back Pain Diseases 0.000 description 1
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 1
- 235000018185 Betula X alpestris Nutrition 0.000 description 1
- 235000018212 Betula X uliginosa Nutrition 0.000 description 1
- 235000002566 Capsicum Nutrition 0.000 description 1
- ACTIUHUUMQJHFO-UHFFFAOYSA-N Coenzym Q10 Natural products COC1=C(OC)C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UHFFFAOYSA-N 0.000 description 1
- 235000005320 Coleus barbatus Nutrition 0.000 description 1
- 206010010774 Constipation Diseases 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 1
- SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 description 1
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 description 1
- 239000004386 Erythritol Substances 0.000 description 1
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- SHZGCJCMOBCMKK-JFNONXLTSA-N L-rhamnopyranose Chemical compound C[C@@H]1OC(O)[C@H](O)[C@H](O)[C@H]1O SHZGCJCMOBCMKK-JFNONXLTSA-N 0.000 description 1
- PNNNRSAQSRJVSB-UHFFFAOYSA-N L-rhamnose Natural products CC(O)C(O)C(O)C(O)C=O PNNNRSAQSRJVSB-UHFFFAOYSA-N 0.000 description 1
- 239000004166 Lanolin Substances 0.000 description 1
- 240000007472 Leucaena leucocephala Species 0.000 description 1
- 235000010643 Leucaena leucocephala Nutrition 0.000 description 1
- 239000004367 Lipase Substances 0.000 description 1
- 102000004882 Lipase Human genes 0.000 description 1
- 108090001060 Lipase Proteins 0.000 description 1
- 206010049287 Lipodystrophy acquired Diseases 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 description 1
- ATGQXSBKTQANOH-UWVGARPKSA-N N-oleoylphytosphingosine Chemical compound CCCCCCCCCCCCCC[C@@H](O)[C@@H](O)[C@H](CO)NC(=O)CCCCCCC\C=C/CCCCCCCC ATGQXSBKTQANOH-UWVGARPKSA-N 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 239000006002 Pepper Substances 0.000 description 1
- 235000016761 Piper aduncum Nutrition 0.000 description 1
- 240000003889 Piper guineense Species 0.000 description 1
- 235000017804 Piper guineense Nutrition 0.000 description 1
- 235000008184 Piper nigrum Nutrition 0.000 description 1
- 241000131459 Plectranthus barbatus Species 0.000 description 1
- 239000004373 Pullulan Substances 0.000 description 1
- 229920001218 Pullulan Polymers 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- MUPFEKGTMRGPLJ-RMMQSMQOSA-N Raffinose Natural products O(C[C@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](O[C@@]2(CO)[C@H](O)[C@@H](O)[C@@H](CO)O2)O1)[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 MUPFEKGTMRGPLJ-RMMQSMQOSA-N 0.000 description 1
- QNVSXXGDAPORNA-UHFFFAOYSA-N Resveratrol Natural products OC1=CC=CC(C=CC=2C=C(O)C(O)=CC=2)=C1 QNVSXXGDAPORNA-UHFFFAOYSA-N 0.000 description 1
- 240000006661 Serenoa repens Species 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- 229920002385 Sodium hyaluronate Polymers 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
- NWGKJDSIEKMTRX-AAZCQSIUSA-N Sorbitan monooleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O NWGKJDSIEKMTRX-AAZCQSIUSA-N 0.000 description 1
- IYFATESGLOUGBX-YVNJGZBMSA-N Sorbitan monopalmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O IYFATESGLOUGBX-YVNJGZBMSA-N 0.000 description 1
- HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- LUKBXSAWLPMMSZ-OWOJBTEDSA-N Trans-resveratrol Chemical compound C1=CC(O)=CC=C1\C=C\C1=CC(O)=CC(O)=C1 LUKBXSAWLPMMSZ-OWOJBTEDSA-N 0.000 description 1
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 description 1
- 241001506047 Tremella Species 0.000 description 1
- MUPFEKGTMRGPLJ-UHFFFAOYSA-N UNPD196149 Natural products OC1C(O)C(CO)OC1(CO)OC1C(O)C(O)C(O)C(COC2C(C(O)C(O)C(CO)O2)O)O1 MUPFEKGTMRGPLJ-UHFFFAOYSA-N 0.000 description 1
- 235000018936 Vitellaria paradoxa Nutrition 0.000 description 1
- 241001135917 Vitellaria paradoxa Species 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
- NCHJGQKLPRTMAO-XWVZOOPGSA-N [(2R)-2-[(2R,3R,4S)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl] 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O NCHJGQKLPRTMAO-XWVZOOPGSA-N 0.000 description 1
- DRRMRHKHTQRWMB-UHFFFAOYSA-N [3-(2-ethylhexanoyloxy)-2,2-bis(2-ethylhexanoyloxymethyl)propyl] 2-ethylhexanoate Chemical compound CCCCC(CC)C(=O)OCC(COC(=O)C(CC)CCCC)(COC(=O)C(CC)CCCC)COC(=O)C(CC)CCCC DRRMRHKHTQRWMB-UHFFFAOYSA-N 0.000 description 1
- RCYWWJBNPIWJMJ-UHFFFAOYSA-N [4-(hexadecanoyloxymethyl)-5-hydroxy-6-methylpyridin-3-yl]methyl hexadecanoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC1=CN=C(C)C(O)=C1COC(=O)CCCCCCCCCCCCCCC RCYWWJBNPIWJMJ-UHFFFAOYSA-N 0.000 description 1
- PAUSGZCRNOTKPK-UHFFFAOYSA-N [5-hydroxy-6-methyl-4-(octanoyloxymethyl)pyridin-3-yl]methyl octanoate Chemical compound CCCCCCCC(=O)OCC1=CN=C(C)C(O)=C1COC(=O)CCCCCCC PAUSGZCRNOTKPK-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 206010000496 acne Diseases 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 150000008051 alkyl sulfates Chemical class 0.000 description 1
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 1
- RGZSQWQPBWRIAQ-LSDHHAIUSA-N alpha-Bisabolol Natural products CC(C)=CCC[C@@](C)(O)[C@@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-LSDHHAIUSA-N 0.000 description 1
- 125000003368 amide group Chemical group 0.000 description 1
- 208000022531 anorexia Diseases 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 239000002830 appetite depressant Substances 0.000 description 1
- BTFJIXJJCSYFAL-UHFFFAOYSA-N arachidyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCO BTFJIXJJCSYFAL-UHFFFAOYSA-N 0.000 description 1
- 229960000271 arbutin Drugs 0.000 description 1
- 206010003246 arthritis Diseases 0.000 description 1
- 229940072107 ascorbate Drugs 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- 235000021302 avocado oil Nutrition 0.000 description 1
- 239000008163 avocado oil Substances 0.000 description 1
- 208000019804 backache Diseases 0.000 description 1
- 235000013871 bee wax Nutrition 0.000 description 1
- 239000012166 beeswax Substances 0.000 description 1
- 229940092738 beeswax Drugs 0.000 description 1
- VKIJBOMCWLTQBD-UHFFFAOYSA-N benzoic acid N-(2-hydroxyphenyl)propanamide Chemical compound C(C1=CC=CC=C1)(=O)O.C(CC)(=O)NC1=C(C=CC=C1)O VKIJBOMCWLTQBD-UHFFFAOYSA-N 0.000 description 1
- 229960003237 betaine Drugs 0.000 description 1
- 229940036350 bisabolol Drugs 0.000 description 1
- HHGZABIIYIWLGA-UHFFFAOYSA-N bisabolol Natural products CC1CCC(C(C)(O)CCC=C(C)C)CC1 HHGZABIIYIWLGA-UHFFFAOYSA-N 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 230000037237 body shape Effects 0.000 description 1
- 230000001914 calming effect Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 239000004359 castor oil Substances 0.000 description 1
- 235000019438 castor oil Nutrition 0.000 description 1
- 229940099417 ceramide 2 Drugs 0.000 description 1
- 229940044176 ceramide 3 Drugs 0.000 description 1
- 229960000541 cetyl alcohol Drugs 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229960003993 chlorphenesin Drugs 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 229940107161 cholesterol Drugs 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000003240 coconut oil Substances 0.000 description 1
- 235000019864 coconut oil Nutrition 0.000 description 1
- ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 description 1
- 235000017471 coenzyme Q10 Nutrition 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 235000005687 corn oil Nutrition 0.000 description 1
- 239000002285 corn oil Substances 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 229920006037 cross link polymer Polymers 0.000 description 1
- 239000002454 curcuma longa l. root extract Substances 0.000 description 1
- 206010061428 decreased appetite Diseases 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 229940008099 dimethicone Drugs 0.000 description 1
- 239000004205 dimethyl polysiloxane Substances 0.000 description 1
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 1
- PKPOVTYZGGYDIJ-UHFFFAOYSA-N dioctyl carbonate Chemical compound CCCCCCCCOC(=O)OCCCCCCCC PKPOVTYZGGYDIJ-UHFFFAOYSA-N 0.000 description 1
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 description 1
- IYGFDEZBVCNBRU-UHFFFAOYSA-L disodium sulfuric acid sulfate Chemical class [H+].[H+].[H+].[H+].[Na+].[Na+].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O IYGFDEZBVCNBRU-UHFFFAOYSA-L 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 229940009714 erythritol Drugs 0.000 description 1
- 235000019414 erythritol Nutrition 0.000 description 1
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 125000005456 glyceride group Chemical group 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 229940075529 glyceryl stearate Drugs 0.000 description 1
- 239000008169 grapeseed oil Substances 0.000 description 1
- 229960004881 homosalate Drugs 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 229940071826 hydroxyethyl cellulose Drugs 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 229940071676 hydroxypropylcellulose Drugs 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 210000001596 intra-abdominal fat Anatomy 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- KUVMKLCGXIYSNH-UHFFFAOYSA-N isopentadecane Natural products CCCCCCCCCCCCC(C)C KUVMKLCGXIYSNH-UHFFFAOYSA-N 0.000 description 1
- 229940115478 isopropyl lauroyl sarcosinate Drugs 0.000 description 1
- 229940074928 isopropyl myristate Drugs 0.000 description 1
- 229940119170 jojoba wax Drugs 0.000 description 1
- 235000019388 lanolin Nutrition 0.000 description 1
- 229940039717 lanolin Drugs 0.000 description 1
- 229940071085 lauroyl glutamate Drugs 0.000 description 1
- 235000019421 lipase Nutrition 0.000 description 1
- 208000006132 lipodystrophy Diseases 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000010487 meadowfoam seed oil Substances 0.000 description 1
- 238000000691 measurement method Methods 0.000 description 1
- 230000004630 mental health Effects 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 229940100485 methyl gluceth-10 Drugs 0.000 description 1
- 229940031722 methyl gluceth-20 Drugs 0.000 description 1
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
- 229960002216 methylparaben Drugs 0.000 description 1
- 239000004200 microcrystalline wax Substances 0.000 description 1
- 235000019808 microcrystalline wax Nutrition 0.000 description 1
- 229940114937 microcrystalline wax Drugs 0.000 description 1
- 229940105132 myristate Drugs 0.000 description 1
- 229940043348 myristyl alcohol Drugs 0.000 description 1
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 1
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 1
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 1
- 229940060184 oil ingredients Drugs 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- BJRNKVDFDLYUGJ-UHFFFAOYSA-N p-hydroxyphenyl beta-D-alloside Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-UHFFFAOYSA-N 0.000 description 1
- 230000036407 pain Effects 0.000 description 1
- 229940101267 panthenol Drugs 0.000 description 1
- 239000011619 pantothenol Substances 0.000 description 1
- 235000020957 pantothenol Nutrition 0.000 description 1
- 229940056211 paraffin Drugs 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 229940100460 peg-100 stearate Drugs 0.000 description 1
- WCVRQHFDJLLWFE-UHFFFAOYSA-N pentane-1,2-diol Chemical compound CCCC(O)CO WCVRQHFDJLLWFE-UHFFFAOYSA-N 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 229960005323 phenoxyethanol Drugs 0.000 description 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
- 229940067107 phenylethyl alcohol Drugs 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 230000019612 pigmentation Effects 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 1
- 229940061570 polyglyceryl-10 stearate Drugs 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 235000010241 potassium sorbate Nutrition 0.000 description 1
- 239000004302 potassium sorbate Substances 0.000 description 1
- 229940069338 potassium sorbate Drugs 0.000 description 1
- 229940078492 ppg-17 Drugs 0.000 description 1
- 229940116393 ppg-20 methyl glucose ether Drugs 0.000 description 1
- XLCIFRJORZNGEV-UHFFFAOYSA-N propan-2-yl 2-[dodecanoyl(methyl)amino]acetate Chemical compound CCCCCCCCCCCC(=O)N(C)CC(=O)OC(C)C XLCIFRJORZNGEV-UHFFFAOYSA-N 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
- 229960003415 propylparaben Drugs 0.000 description 1
- 235000019423 pullulan Nutrition 0.000 description 1
- 229940095042 pyridoxine dipalmitate Drugs 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- MUPFEKGTMRGPLJ-ZQSKZDJDSA-N raffinose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)O1 MUPFEKGTMRGPLJ-ZQSKZDJDSA-N 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- NPCOQXAVBJJZBQ-UHFFFAOYSA-N reduced coenzyme Q9 Natural products COC1=C(O)C(C)=C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)C(O)=C1OC NPCOQXAVBJJZBQ-UHFFFAOYSA-N 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 229940016667 resveratrol Drugs 0.000 description 1
- 235000021283 resveratrol Nutrition 0.000 description 1
- 229940108325 retinyl palmitate Drugs 0.000 description 1
- 235000019172 retinyl palmitate Nutrition 0.000 description 1
- 239000011769 retinyl palmitate Substances 0.000 description 1
- 108700004121 sarkosyl Proteins 0.000 description 1
- 229940057910 shea butter Drugs 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 229960003885 sodium benzoate Drugs 0.000 description 1
- BTURAGWYSMTVOW-UHFFFAOYSA-M sodium dodecanoate Chemical compound [Na+].CCCCCCCCCCCC([O-])=O BTURAGWYSMTVOW-UHFFFAOYSA-M 0.000 description 1
- 229940010747 sodium hyaluronate Drugs 0.000 description 1
- 229940082004 sodium laurate Drugs 0.000 description 1
- 229940045885 sodium lauroyl sarcosinate Drugs 0.000 description 1
- KSAVQLQVUXSOCR-UHFFFAOYSA-M sodium lauroyl sarcosinate Chemical compound [Na+].CCCCCCCCCCCC(=O)N(C)CC([O-])=O KSAVQLQVUXSOCR-UHFFFAOYSA-M 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 229940045870 sodium palmitate Drugs 0.000 description 1
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 1
- GGXKEBACDBNFAF-UHFFFAOYSA-M sodium;hexadecanoate Chemical compound [Na+].CCCCCCCCCCCCCCCC([O-])=O GGXKEBACDBNFAF-UHFFFAOYSA-M 0.000 description 1
- 229940035044 sorbitan monolaurate Drugs 0.000 description 1
- 239000001593 sorbitan monooleate Substances 0.000 description 1
- 235000011069 sorbitan monooleate Nutrition 0.000 description 1
- 229940035049 sorbitan monooleate Drugs 0.000 description 1
- 239000001570 sorbitan monopalmitate Substances 0.000 description 1
- 235000011071 sorbitan monopalmitate Nutrition 0.000 description 1
- 229940031953 sorbitan monopalmitate Drugs 0.000 description 1
- 239000001587 sorbitan monostearate Substances 0.000 description 1
- 235000011076 sorbitan monostearate Nutrition 0.000 description 1
- 229940035048 sorbitan monostearate Drugs 0.000 description 1
- 229950004959 sorbitan oleate Drugs 0.000 description 1
- 229940032094 squalane Drugs 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 229940100458 steareth-21 Drugs 0.000 description 1
- 229940012831 stearyl alcohol Drugs 0.000 description 1
- 150000003871 sulfonates Chemical class 0.000 description 1
- 235000020238 sunflower seed Nutrition 0.000 description 1
- 229940104261 taurate Drugs 0.000 description 1
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 1
- TUNFSRHWOTWDNC-UHFFFAOYSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCCC(O)=O TUNFSRHWOTWDNC-UHFFFAOYSA-N 0.000 description 1
- 229940042585 tocopherol acetate Drugs 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 description 1
- 229940035936 ubiquinone Drugs 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/718—Starch or degraded starch, e.g. amylose, amylopectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
- A61K36/634—Forsythia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/732—Starch; Amylose; Amylopectin; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/06—Preparations for care of the skin for countering cellulitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Birds (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Medical Informatics (AREA)
- Dermatology (AREA)
- Alternative & Traditional Medicine (AREA)
- Diabetes (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a beautiful and light herbal liquid, and relates to the technical field of skin external products; the beautifying and slimming herbal liquid comprises a combination of fructus forsythiae extract, maltodextrin, golden yellow chamomile extract and citric acid. The herbal liquid with light beautiful appearance is beneficial to improving the internal environment of the intestinal tract, enhancing the function of the intestinal tract, improving the function of the whole digestive system, promoting the elimination of waste, accelerating the combustion of fat, and fundamentally improving the metabolism in the body, thereby essentially achieving the effects of losing weight and reducing fat.
Description
Technical Field
The invention relates to the technical field of skin external products, in particular to a beautiful and light herbal liquid.
Background
Along with the progress and development of society, the living standard of people is higher and higher, the proportion of the people suffering from the autologous lipodystrophy is increased, and the physiology and the psychology of people are burdened.
The obesity not only affects the body beauty, but also reduces the personal charm due to the body shape deformation caused by the obesity, and causes much inconvenience in personal life; meanwhile, obesity brings psychological damage to people, obese people are easy to reject and jeer, obese people rarely participate in social activities for self-respect protection, and are isolated and distant from other people in schools and societies, which can cause bad influence on career and love over time, so people pay more attention to body beauty and physical and mental health.
At present, main measures for losing weight are as follows: 1. changing lifestyle, controlling diet, reducing fat intake, balancing diet, and burning fat with exercise; 2. the drug therapy is an appetite inhibitor which can act on the center, generally an anorexia drug, and acts on peripheral lipase inhibition, and the aim of losing weight is achieved by blocking fat absorption in diet.
Most of various weight-reducing products in the market, such as variegated foods, medicines, health-care products and the like, adopt methods of controlling appetite or diarrhea and the like to achieve the purpose of reducing weight, are easy to cause malnutrition and are harmful to body health.
Disclosure of Invention
In order to overcome the defects of the prior art, the invention provides a herbal liquid for beautifying and lightening. The herbal liquid with light beautiful appearance is beneficial to improving the internal environment of the intestinal tract, enhancing the function of the intestinal tract, improving the function of the whole digestive system, promoting the elimination of waste, accelerating the combustion of fat, and fundamentally improving the metabolism in the body, thereby essentially achieving the effects of losing weight and reducing fat.
In order to solve the above problems, the present invention proposes the following technical solutions:
in a first aspect, the present invention provides the use of a combination of forsythia suspense extract, maltodextrin, chamomile extract and citric acid for the preparation of a composition for external application to the skin having a metabolism-promoting effect.
Preferably, in the skin external composition, the forsythia suspense extract is contained in an amount of 1 to 5%, the maltodextrin is contained in an amount of 2 to 6%, the chamomile extract is contained in an amount of 3 to 6%, and the citric acid is contained in an amount of 0.1 to 1%, based on the total weight of the skin external composition.
More preferably, in the skin external composition, the forsythia suspense extract is contained in an amount of 2 to 4%, the maltodextrin is contained in an amount of 3 to 6%, the chamomile extract is contained in an amount of 4 to 5.5%, and the citric acid is contained in an amount of 0.6 to 1%, based on the total weight of the skin external composition.
The composition for external application to the skin described in the present invention includes, but is not limited to, pharmaceutical compositions and cosmetic compositions, preferably cosmetic compositions, more preferably skin care cosmetic compositions.
In a second aspect, the present invention provides a beautiful and light herbal liquid comprising a combination of forsythia suspensa extract, maltodextrin, chamomile extract and citric acid.
Specifically, in the beautiful light herbal liquid of the invention, forsythia suspense extract, maltodextrin, golden chamomile extract and citric acid are used as a composition with the effect of promoting metabolism, wherein the forsythia suspense extract has a remarkable anti-inflammatory effect, can remarkably inhibit inflammatory exudation and edema, can remarkably inhibit the formation of inflammatory barriers but enhance the formation of the inflammatory barriers, and can remarkably reduce the exudation of 3P marked erythrocytes from capsules; the maltodextrin has the effects of promoting metabolism, whitening skin, removing facial pigmentation, promoting discharge of body waste, loosening bowel to relieve constipation, and reducing weight and fat; maltodextrin can also increase the anti-aging property of weak acid, and reduce skin irritation caused by other acidity, thereby achieving skin tightening. The golden chamomile extract has the functions of resisting inflammation, calming, naturally reducing pains related to arthritis, injuries, backache and fever and enhancing capillary resistance; the citric acid has the effects of resisting oxidation, resisting aging, keeping moisture, supplementing water, regulating pH value of skin, effectively controlling secretion of skin oil, resisting damage of free radicals to skin, and making skin smooth, white, tender and fine. In the invention, the addition of citric acid can also promote the skin to absorb the forsythia suspense extract, maltodextrin and golden chamomile extract.
The applicant finds that the above four components act synergistically to have significant effects in improving the function of the digestive system, promoting the removal of waste products, and accelerating the combustion of fats.
In the invention, the applicant finds out through experiments that the corresponding effect cannot be achieved by using other similar regulators to replace citric acid to be matched with the components.
Compared with any three or any two or any one of forsythia suspense extract, maltodextrin, golden chamomile extract and citric acid, the beautifying light herbal liquid can remarkably promote metabolism, which shows that the combination of the forsythia suspense extract, the maltodextrin, the golden chamomile extract and the citric acid has a synergistic effect, and also shows that the combination is not simple replacement or superposition among the existing components.
Meanwhile, the herbal liquid for beautifying and lightening the skin is further added with hydroxyphenylpropionamide benzoic acid; the content of the hydroxyphenylpropionamide benzoic acid is 0.05 to 1.5 percent, preferably 0.1 to 1.2 percent; hydroxyphenyl propionamide benzoic acid, has antihistaminic, anti-irritant, and antipruritic effects; can effectively inhibit skin erythema, edema and pruritus caused by histamine, and improve the safety performance of the beautiful and light herbal liquid.
The application method of the herbal liquid for beautifying and lightening comprises the following steps: the product is applied to the skin of the whole body, and the skin is massaged until the product is completely absorbed.
The weight-losing and fat-reducing effects can be realized through massage, the principle of weight-losing is completely different from that of the prior method for controlling appetite or adopting diarrhea and the like, malnutrition and harm to body health can not be caused, and the safety performance is higher.
Preferably, in the beautiful light herbal liquid, the content of the forsythia suspense extract is 1-5%, the content of the maltodextrin is 2-6%, the content of the chamomile extract is 3-6%, the content of the citric acid is 0.1-1%, the content of the hydroxyphenylpropionamide benzoic acid is 0.05-1.5%, based on the total weight of the beautiful light herbal liquid.
More preferably, in the beautiful light herbal liquid, the content of the forsythia suspense extract is 2-4%, the content of maltodextrin is 3-6%, the content of the chamomile extract is 4-5.5%, the content of citric acid is 0.6-1%, and the content of hydroxyphenylpropionamide benzoic acid is 0.1-1.2%, based on the total weight of the beautiful light herbal liquid.
In a third aspect, there is provided a method for improving the metabolism promoting effect of a composition for external application to the skin, the method comprising: a combination of forsythia suspense extract, maltodextrin, golden chamomile extract and citric acid is added to a skin external composition.
By adding the forsythia extract, the maltodextrin, the golden chamomile extract and the citric acid, the skin external composition is beneficial to improving the internal environment of an intestinal tract, enhancing the function of the intestinal tract, improving the function of the whole digestive system, promoting the elimination of waste, accelerating the combustion of fat, fundamentally improving the metabolism in the body, and essentially achieving the effects of losing weight and reducing fat.
Preferably, in the skin external composition, the content of the forsythia suspense extract is 1-5%, the content of the maltodextrin is 2-6%, the content of the chamomile extract is 3-6%, and the content of the citric acid is 0.1-1%, based on the total weight of the skin external composition.
More preferably, in the composition for external application to skin, the content of forsythia suspense extract is 2 to 4%, the content of maltodextrin is 3 to 6%, the content of chamomile extract is 4 to 5.5%, and the content of citric acid is 0.6 to 1%, based on the total weight of the composition for external application to skin.
Meanwhile, the composition for external application to skin of the present invention further comprises hydroxyphenylpropionamide benzoic acid; the content of the hydroxyphenylpropionamide benzoic acid is 0.05 to 1.5 percent, and preferably 0.1 to 1.2 percent; hydroxyphenylpropionamide benzoic acid, has antihistaminic, anti-irritant and antipruritic effects; can effectively inhibit skin erythema, edema and pruritus caused by histamine, and improve the safety performance of the beautiful and light herbal liquid.
Specifically, the skin external composition is a pharmaceutical composition or a cosmetic composition.
When the skin external composition of the present invention is a cosmetic composition, the skin external composition of the present invention may optionally comprise conventional ingredients of cosmetic compositions, including any known in the art, such as vehicles, surfactants, skin care active ingredients, and cosmetic adjuvants, in addition to the above-mentioned components, and the type and amount thereof may be selected according to specific needs. Generally, the content of the conventional ingredients is 1 to 95% by weight based on the total weight of the skin external composition.
In the present invention, such vehicles are known in the art and include, but are not limited to, diluents, dispersants or carriers, and the like, including, but not limited to, ethanol, butylene glycol, dipropylene glycol, and the like. The type and amount can be selected by those skilled in the art according to the actual needs. Generally, in the composition for external application to the skin of the present invention, the vehicle accounts for 1 to 20% of the total weight of the common ingredients.
The surfactant is any type of surfactant commonly used in cosmetics for reducing the surface tension of the interface, which can achieve the purpose of cleaning, emulsifying, stabilizing the system. Such surfactants include, but are not limited to, fatty acid soaps (e.g., sodium laurate, sodium palmitate, etc.), higher alkyl sulfates (e.g., sodium lauryl sulfate, etc.), N-acyl sarcosines (e.g., sodium lauroyl sarcosinate, etc.), higher fatty acid amide sulfonates (e.g., sodium lauryl methyl taurate, etc.), alkylbenzene sulfonates, higher fatty acid ester sulfates (e.g., hardened coconut oil fatty acid sodium glycerosulfate, etc.), N-acyl glutamates, lauryl dimethylaminoacetic acid betaine, alkyl betaines, amido betaines, sorbitan fatty acid esters (e.g., sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan oleate), PEG-alkyl ethers (e.g., PEG-2-octyl dodecyl ether, etc.), sodium sesqui sulfates, etc, Sucrose fatty acid ester, etc. For a particular surfactant, one skilled in the art can select the type and amount thereof as desired. Generally, in the composition for external application to the skin of the present invention, the surfactant is 1 to 50% by weight of the total weight of the common ingredients.
Such skin care actives are known in the art and include, but are not limited to, moisturizers, skin conditioners, emollients, and the like. The humectant includes but is not limited to one or more combinations of glycerin, trehalose, sucrose, panthenol, propylene glycol, 1, 2-pentanediol, mannitol, glycerol polyether-26, rhamnose, raffinose, erythritol, polyethylene glycol-8, polyethylene glycol-32, methyl gluceth-10, methyl gluceth-20, PEG/PPG-17/6 copolymer, sodium polyglutamate, xylitol, urea, hydrolyzed sclerotium rolfsii gum, sodium polyglutamate, glycerol glucoside, PPG-10 methyl glucose ether, pullulan, tremella polysaccharide, PPG-20 methyl glucose ether, and the like. Generally, in the composition for external application to the skin of the present invention, the moisturizer accounts for 1 to 35% of the total weight of the conventional ingredients.
The skin conditioner has effects of keeping moisture, removing wrinkle, removing speckle, eliminating acne, and controlling oil. The skin conditioning agent includes, but is not limited to, one or more combinations of phytosterol/octyldodecanol lauroyl glutamate, turmeric root extract, ceramide 2, ceramide 3, hydrolyzed sodium hyaluronate, acetyl phytosphingosine, cholesterol, allantoin, birch bark extract, hydrogenated lecithin, arbutin, acetyl phytosphingosine, resveratrol, palmetto bark extract, coleus forskohlii root extract, bisabolol, tetraisopalmitate ascorbate, pepper seed extract, ubiquinone, pyridoxine dipalmitate, pyridoxine dicaprylate, retinol palmitate, tocopherol acetate, oat kernel extract, and the like. Generally, in the skin external composition of the present invention, the skin conditioner is 0.05 to 50% by weight of the total weight of the common ingredients.
The emollients include, but are not limited to, one or more combinations of tri (ethyl hexanoate) glyceride, isopropyl lauroyl sarcosinate, caprylic/capric triglyceride, grape seed oil, meadowfoam seed oil, shea butter, cetyl alcohol, dimethicone, pentaerythritol tetra (ethyl hexanoate), olive oil, avocado oil, corn oil, dioctyl carbonate, homosalate, squalane, stearyl alcohol, isopropyl myristate, myristyl alcohol, hydrogenated polydecene, murumuru fruit oil, sunflower seed oil, isohexadecane, jojoba oil, lanolin, paraffin, microcrystalline wax, beeswax, and the like. Generally, in the skin external composition of the present invention, the emollient represents 0.05 to 50% by weight of the total weight of the conventional ingredients.
The cosmetic adjuvants include, but are not limited to, emulsifiers, thickeners, preservatives, fragrances, and the like.
Such emulsifiers include, but are not limited to, one or more combinations of sorbitan olivetoleate, steareth-21, PEG-60 hydrogenated castor oil, glyceryl stearate/PEG-100 stearate, PPG-13-decyltetraeth-24, cetearyl glucoside, polyglyceryl-10 myristate, cetearyl glucoside, polyglyceryl-10 stearate, polyglyceryl-10 dioleate, and the like. The type and amount can be specifically selected by those skilled in the art as desired.
The thickener includes, but is not limited to, one or more combinations of hydroxyethyl cellulose, hydroxypropyl cellulose, carbomer, xanthan gum, acacia, polyethylene glycol-14M, polyethylene glycol-90M, succinoglycan, acrylic acid/C10-30 alkanol acrylate crosspolymer, and the like.
The preservative includes, but is not limited to, one or more of methylparaben, propylparaben, phenoxyethanol, benzyl alcohol, phenylethyl alcohol, potassium sorbate, sodium benzoate, chlorphenesin, and the like. Generally, in the composition for external application to the skin of the present invention, the preservative is 0.01 to 5% by weight based on the total weight of the common ingredients.
When the composition for external application to the skin of the present invention is a pharmaceutical composition, the composition for external application to the skin of the present invention may optionally contain the usual ingredients of the pharmaceutical composition, including any known in the art such as pharmaceutically active ingredients, in addition to the above-mentioned components, and the type and amount thereof may be selected according to specific needs. The pharmaceutically active ingredients are ingredients known in the art for cosmetic and skin care. Generally, in the composition for external application to the skin of the present invention, the pharmaceutically active ingredient accounts for 0.05 to 85% of the total weight of the commonly used ingredients.
The preparation of the skin external composition of the present invention can be prepared by any suitable method known in the art. For example, it can be prepared using a vessel such as a dissolution tank, an emulsifying pot, a disperser, a transfer pump, etc., which are commonly used in the art. The preparation method comprises putting water soluble substance into water phase dissolving kettle, putting oil soluble substance into oil phase dissolving kettle, and heating the two kettles to about 80 deg.C respectively, wherein the raw material easy to agglomerate can be pre-dispersed with disperser. After the dissolution is finished, the oil phase and the water phase are conveyed into an emulsifying pot, and homogenized and emulsified for about 5-15 minutes. After emulsification, the temperature of the material body is reduced to normal temperature, and essence, preservative and the like are optionally added. After the relevant detection indexes are qualified, the products can be filled and delivered.
The preparation method can be deleted or adjusted according to the requirements of dosage forms. The composition can be made into pharmaceutical composition or cosmetic composition in various dosage forms such as liquid, lotion, ointment, cream or gel.
Compared with the prior art, the invention has the following beneficial effects:
the invention discloses a skin external composition (beautiful and light herbal liquid) added with forsythia extract, maltodextrin, golden yellow chamomile extract and citric acid, which is helpful for improving the internal environment of an intestinal tract, enhancing the function of the intestinal tract, improving the function of the whole digestive system, promoting the elimination of waste, accelerating the combustion of fat, and fundamentally improving the metabolism in the body, thereby essentially achieving the effects of losing weight and reducing fat and having excellent stability and safety performance.
Additional aspects and advantages of the invention will be set forth in part in the description which follows, and in part will be obvious from the description, or may be learned by practice of the invention.
Detailed Description
The technical solutions in the embodiments will be clearly and completely described below with reference to the embodiments of the present invention. It is apparent that the embodiments to be described below are only a part of the embodiments of the present invention, and not all of them. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
It will be understood that the terms "comprises" and/or "comprising," when used in this specification and the appended claims, specify the presence of stated features, integers, steps, operations, elements, and/or components, but do not preclude the presence or addition of one or more other features, integers, steps, operations, elements, components, and/or groups thereof.
It is also to be understood that the terminology used in the description of the embodiments of the invention herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the embodiments of the invention. As used in the description of embodiments of the present invention and the appended claims, the singular forms "a," "an," and "the" are intended to include the plural forms as well, unless the context clearly indicates otherwise.
The components in the embodiment of the invention are calculated according to weight percentage; the starting materials in the examples of the present invention are all commercially available.
In the following examples, sonography is referenced: [1] zhannie, Zhang Shenglan, the clinical value of intraabdominal fat was measured by ultrasound [ J ]. Shandong medicine, 1991, (03):26.
Example 1: preparing samples of experimental group and control group
In this example, composition samples (beauty light herbal solutions) having the following formulations were prepared, wherein compositions 1 to 3 were experimental groups of the present invention, and combinations 4 to 7 were control group samples, and the specific compositions are shown in table 1.
Table 1: components and amounts (%)
The preparation method of the composition comprises the following steps:
1) heating glycerol, methyl hydroxybenzoate, butanediol, allantoin and part of water to 75 deg.C to completely dissolve; after cooling, adding carbomer while stirring until carbomer is well swelled; adding fructus forsythiae extract, maltodextrin, flos Chrysanthemi extract and hydroxyphenylpropionamide benzoic acid at a certain proportion, stirring for dissolving;
2) adding citric acid after completely dissolving, adding water for supplementing, and stirring to obtain a sample (beautiful and light herbal liquid).
The application method of the herbal liquid for beautifying and lightening comprises the following steps: the product is applied to the skin of the whole body, and the skin is massaged until the product is completely absorbed.
Effect verification:
the efficacy of the compositions 1 to 7 in promoting metabolism was verified, specifically, the change in the thickness of subcutaneous fat before and after use of the user, more specifically, the change in the thickness of subcutaneous fat in the thigh region and the change in the thickness of subcutaneous fat in the abdomen region were measured.
The specific test steps are as follows:
160 female volunteers with weight of 65-70 kg and partial fat were randomly recruited to test the effect of the composition 1-7. Dividing all volunteers into 8 groups randomly, wherein the 1 st to 7 th groups are respectively corresponding to the compositions 1 to 7, and the 8 th group does not use any weight-reducing product or take any weight-reducing medicine; the thickness of the subcutaneous fat of the thigh and abdomen (test area of the same size and location) was measured using a probe and recorded by using a conventional ultrasonic measurement method, respectively. The use method of the compositions 1 to 7 is as follows: applying the product to the skin of the whole body, and massaging until the product is completely absorbed, wherein the dosage of the product is 0.2g/10cm 2 . During the test period, all volunteers can correctly use the corresponding product (diet is normal) according to the relevant requirements, and do not enable the volunteers to use the corresponding productUsing other weight-reducing products or taking weight-reducing medicines.
The thickness of the subcutaneous fat in the thigh and abdomen (test area) was measured at week 4 and week 8, respectively, using the above composition, and the specific data is shown in table 2 (data is the average of each group of volunteers).
Table 2: experimental results for compositions 1 to 7
In the experimental process, each volunteer synchronously records the index change conditions of the skin oil secretion degree, the weight change, the blood fat reduction and the like in the using process.
The judgment standard is as follows:
remarkably: the skin secretes oil to normal degree, the body weight is gradually recovered to normal (obviously reduced), and the blood fat is obviously reduced (the value of the triglyceride is reduced to be more than 4 mmol/L);
the method has the following advantages: reduction of oil and fat secretion from skin, reduction of body weight (insignificant), reduction of blood fat ((triglyceride value reduction of 1-4mmol/L))
And (4) invalidation: there was essentially no change before oil and body weight were secreted.
The results are shown in Table 3.
Table 3:
according to the test results in tables 2 and 3, the compositions 1 to 3 of the invention can obviously accelerate the combustion of fat, and fundamentally increase the metabolism in vivo, so that the effects of losing weight and reducing fat can be essentially achieved, while the compositions 4 to 7 adopt any two or three of forsythia extract, maltodextrin, golden chamomile extract and citric acid, and the weight-losing and fat-reducing effects of the compositions 4 to 7 are obviously inferior to those of the compositions 1 to 3. The invention shows that the combination of forsythia suspense extract, maltodextrin, golden chamomile extract and citric acid has a synergistic effect, and the combination is not the simple superposition of the existing components.
Example 2: in this example, to further verify that the compositions of the present invention have synergistic effects, control samples having the following formulations were prepared, respectively; in composition 8, the citric acid in composition 1 of the present invention was replaced with tromethamine, and the specific composition is shown in table 4.
Table 4: components and amounts (%)
The preparation method of the composition 8 comprises the following steps:
1) heating glycerol, methyl hydroxybenzoate, butanediol, allantoin and part of water to 75 deg.C to completely dissolve; after cooling, adding carbomer while stirring until carbomer is well swelled; adding fructus forsythiae extract, maltodextrin, flos Chrysanthemi extract and hydroxyphenylpropionamide benzoic acid at a certain proportion, stirring for dissolving;
2) adding tromethamine after completely dissolving, adding water for complementing, and uniformly stirring to obtain a sample (beautiful and light herbal liquid).
The application method of the herbal liquid for beautifying and lightening comprises the following steps: the product is applied to the skin of the whole body, and is massaged until the product is completely absorbed.
The same experiment was carried out under the same conditions (number of test persons and time) for composition 8 with reference to the effect verification of compositions 1 to 7 in example 1, and the experimental results are shown in tables 5 and 6.
Table 5:
table 6:
group of | Show effect | Is effective | Invalidation |
Blank group | 0 | 0 | 20 |
Composition 1 | 20 | 0 | 0 |
Composition 8 | 6 | 12 | 2 |
According to the test results in tables 5 and 6, it can be seen that citric acid is required to be used in combination with forsythia suspense extract, maltodextrin and golden yellow chamomile extract to achieve a synergistic effect, and the principle of the synergistic effect is that the citric acid not only can better exert the effects of the forsythia suspense extract, the maltodextrin and the golden yellow chamomile extract, but also can promote the skin to absorb the forsythia suspense extract, the maltodextrin and the golden yellow chamomile extract, so that the effects of the composition on increasing the metabolism in vivo and losing weight and reducing fat are remarkably improved.
The invention synchronously verifies the influence of other pH regulators, plant extracts, traditional Chinese medicine extracts and the like on the composition in the experimental process, and test results show that the synergistic effect is achieved only by using the forsythia suspensa extract, the maltodextrin, the golden chamomile extract and the citric acid in a matching way. Meanwhile, the composition of the invention can pass the related tests of stability and irritation, and has excellent stability and safety performance.
In conclusion, the composition of forsythia suspense extract, maltodextrin, golden chamomile extract and citric acid has a synergistic effect, and the composition is not a simple replacement among the existing components.
The technical solutions provided by the embodiments of the present invention are described in detail above, and the principles and embodiments of the present invention are explained herein by using specific examples, and the descriptions of the embodiments are only used to help understanding the principles of the embodiments of the present invention; meanwhile, for a person skilled in the art, according to the embodiments of the present invention, there may be variations in the specific implementation manners and application ranges, and in summary, the content of the present description should not be construed as a limitation to the present invention.
Claims (10)
1. Use of a combination of forsythia suspense extract, maltodextrin, golden chamomile extract and citric acid for the preparation of a skin external composition having a metabolism-promoting effect.
2. The use according to claim 1, wherein the composition for external application to the skin comprises 1 to 5% of the forsythia suspensa extract, 2 to 6% of the maltodextrin, 3 to 6% of the chamomile extract, and 0.1 to 1% of the citric acid, based on the total weight of the composition for external application to the skin.
3. The use according to claim 1 or 2, wherein in the composition for external application to the skin, the content of the forsythia suspense extract is 2 to 4%, the content of the maltodextrin is 3 to 6%, the content of the chamomile extract is 4 to 5.5%, and the content of the citric acid is 0.6 to 1%, based on the total weight of the composition for external application to the skin.
4. The beautifying light herbal liquid is characterized by comprising a combination of fructus forsythiae extract, maltodextrin, golden yellow chamomile extract and citric acid.
5. The beauty light herbal liquid as claimed in claim 4, wherein the beauty light herbal liquid contains fructus forsythiae extract 1-5%, maltodextrin 2-6%, chamomile extract 3-6%, and citric acid 0.1-1%, based on the total weight of the beauty light herbal liquid.
6. The beautiful light herbal liquid as claimed in claim 4 or 5, wherein in the beautiful light herbal liquid, the content of the forsythia suspensa extract is 2-4%, the content of the maltodextrin is 3-6%, the content of the chamomile extract is 4-5.5%, and the content of the citric acid is 0.6-1% based on the total weight of the beautiful light herbal liquid.
7. A method for improving the metabolism promoting effect of a skin external composition, characterized in that a combination of forsythia suspense extract, maltodextrin, golden chamomile extract and citric acid is added to the skin external composition.
8. The method of claim 7, wherein the composition for external application to the skin comprises 1 to 5% of forsythia suspensa extract, 2 to 6% of maltodextrin, 3 to 6% of chamomile extract, and 0.1 to 1% of citric acid, based on the total weight of the composition for external application to the skin.
9. The method of claim 7, wherein the composition for external application to the skin comprises 2 to 4% of forsythia suspensa extract, 3 to 6% of maltodextrin, 4 to 5.5% of chamomile extract, and 0.6 to 1% of citric acid, based on the total weight of the composition for external application to the skin.
10. The method according to any one of claims 7 to 9, wherein the composition for external application to the skin is a pharmaceutical composition or a cosmetic composition.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202210601371.XA CN114983887A (en) | 2022-05-30 | 2022-05-30 | Beautiful and light herbal liquid |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202210601371.XA CN114983887A (en) | 2022-05-30 | 2022-05-30 | Beautiful and light herbal liquid |
Publications (1)
Publication Number | Publication Date |
---|---|
CN114983887A true CN114983887A (en) | 2022-09-02 |
Family
ID=83030722
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202210601371.XA Pending CN114983887A (en) | 2022-05-30 | 2022-05-30 | Beautiful and light herbal liquid |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN114983887A (en) |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1876178A (en) * | 2006-04-27 | 2006-12-13 | 北京东方兴企食品工业技术有限公司 | Granule with beauty and health function |
CN101507690A (en) * | 2008-12-26 | 2009-08-19 | 扬州市中汇化妆品有限公司 | Bath dew for baby |
CN104645278A (en) * | 2013-11-25 | 2015-05-27 | 詹其旸 | Healthcare herbal tea |
CN107441390A (en) * | 2017-06-16 | 2017-12-08 | 广州中晟生物科技有限公司 | A kind of fat burning and slimming frost and preparation method |
CN108114029A (en) * | 2018-02-08 | 2018-06-05 | 陕西中医药大学 | A kind of active Chinese drug component compositions, its preparation method and its application |
CN109223681A (en) * | 2018-11-22 | 2019-01-18 | 广州森麦生物科技有限公司 | A kind of multiple-effect skin care compositions and the application in cosmetics |
CN109419685A (en) * | 2017-08-31 | 2019-03-05 | 张忠远 | A kind of manufacturing method of essential oil toxin expelling moisturizing nursing honey |
CN111012682A (en) * | 2019-12-23 | 2020-04-17 | 苏州绿叶日用品有限公司 | Slimming nano liposome and preparation method and application thereof |
-
2022
- 2022-05-30 CN CN202210601371.XA patent/CN114983887A/en active Pending
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1876178A (en) * | 2006-04-27 | 2006-12-13 | 北京东方兴企食品工业技术有限公司 | Granule with beauty and health function |
CN101507690A (en) * | 2008-12-26 | 2009-08-19 | 扬州市中汇化妆品有限公司 | Bath dew for baby |
CN104645278A (en) * | 2013-11-25 | 2015-05-27 | 詹其旸 | Healthcare herbal tea |
CN107441390A (en) * | 2017-06-16 | 2017-12-08 | 广州中晟生物科技有限公司 | A kind of fat burning and slimming frost and preparation method |
CN109419685A (en) * | 2017-08-31 | 2019-03-05 | 张忠远 | A kind of manufacturing method of essential oil toxin expelling moisturizing nursing honey |
CN108114029A (en) * | 2018-02-08 | 2018-06-05 | 陕西中医药大学 | A kind of active Chinese drug component compositions, its preparation method and its application |
CN109223681A (en) * | 2018-11-22 | 2019-01-18 | 广州森麦生物科技有限公司 | A kind of multiple-effect skin care compositions and the application in cosmetics |
CN111012682A (en) * | 2019-12-23 | 2020-04-17 | 苏州绿叶日用品有限公司 | Slimming nano liposome and preparation method and application thereof |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN111249209B (en) | Moisturizing repair cream and preparation method thereof | |
CN103237555B (en) | Topical skin care formulation | |
WO2018196481A1 (en) | Moisturizing cosmetics composition | |
KR101910482B1 (en) | Topical skin care formulations comprising jaboticaba and cashew fruit pulps and extracts thereof | |
IL260028B1 (en) | Skin care preparations for babies | |
KR101015702B1 (en) | Compositions comprising Seaweeds extract for improving and alleviating inflammation and irritation of skin | |
CN110731974B (en) | Skin external composition with enhanced anti-inflammatory efficacy | |
CN104586735A (en) | Method for preparing fermented product filtrate by fermenting rice with lactobacillus casei, and application of fermented product filtrate | |
EA006440B1 (en) | Agent for treating, caring and preventing possible damaged skin tissues, process for the production thereof and use | |
CN111801108A (en) | Topical skin care compositions | |
CN110650724A (en) | Composition for promoting melanogenesis comprising Cirsium japonicum extract as active ingredient | |
CN106333880B (en) | toner based on thin emulsion and preparation method thereof | |
KR20090130584A (en) | Cosmetic composition comprising an extract of mixed herbs having skin whitening and wrinkle improving activity | |
TW201200032A (en) | Hyaluronic acid production promoting agent | |
KR100776755B1 (en) | Composition comprising crude drug extract showing anti-itching effect | |
CN109453088B (en) | Whitening and firming cream, preparation method thereof and tyrosinase inhibitor | |
CA2731138C (en) | Compositions for treating rosacea | |
CN110101587A (en) | A kind of anti-inflammatory anti-acne facial treatment milk | |
CN114983887A (en) | Beautiful and light herbal liquid | |
KR20160036834A (en) | Skin external application composition comprising complex fermented extract of crude drug ingredients | |
CN112656728A (en) | Anti-allergy relieving liquid and preparation method thereof | |
KR101814537B1 (en) | A skin topical composition comprising the bio-cellulose powder for reducing and preventing cellulite | |
KR101814538B1 (en) | A cosmentic composition comprising the bio-cellulose powder for reducing and preventing cellulite | |
CN114984101A (en) | Beautiful gel | |
CN114099410B (en) | Face cream composition of liposome with synergistic gain and anti-aging effects and preparation method thereof |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
RJ01 | Rejection of invention patent application after publication |
Application publication date: 20220902 |
|
RJ01 | Rejection of invention patent application after publication |