JPS6256411A - Beautifying agent - Google Patents

Abstract

PURPOSE:A beautifying agent having extremely improved beautifing effects on the skin and high safety, containing one or more compounds selected from sesamol, lecithin, phytic acid, its salt, phosphatidylethanolamine and/or phosphatidylserine, etc. CONSTITUTION:A beautifying agent having beautifying effects on the skin free from side effects unfavorable to the human body, containing 0.005-15wt%, preferably 0.1-10wt% calculated as solid content based on the total amount of composition selected from sesamol, lecithin, phytic acid, its salt, phosphatidylethanolamine, phosphatidylserine, erysorbic acid, its salt, guar gum, nordihydroguaiaretic acid, its salt and propyl gallate as an active ingredient.

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial Field of Application] The present invention relates to a highly safe whitening agent with significantly improved skin whitening effects.

[Conventional technology] Although there are some points that are unclear about the mechanism by which skin spots occur, in general, melanin pigments are formed due to hormonal abnormalities or stimulation of ultraviolet rays from sunlight, and this is caused by the formation of melanin within the skin. It is thought that it is abnormally deposited. Treatments for such bruises include the administration of large amounts of substances that suppress melanin production, such as large doses of vitamin C, injections of glutathione, or the use of ointments, creams, and lotions containing L-ascorbic acid, cysteine, etc. Methods such as making it into a form and applying it locally are used. Additionally, hydroquinone preparations are used as pharmaceuticals in Europe and America.

[Problems to be solved by the invention] L-ascorbic acids have problems in terms of stability, and are unstable in systems containing water, causing discoloration and odor. With the exception of , the onset of the effect is extremely slow, so the whitening effect is not sufficient. On the other hand, although hydroquinone has been shown to be effective, its use is generally restricted due to its sensitizing properties. In order to improve its safety, attempts have been made to use monoesters of higher fatty acids, but these esters are not necessarily safe because they are degraded by hydrolytic enzymes in the body.

[Means for Solving the Problems] In view of the above circumstances, the present inventors have conducted extensive research to develop an excellent skin whitening agent that does not have any unfavorable side effects on the human body, and have found (1) ) Sezamol (2) Lecithin (3) Phytic acid (4) Salt of phytic acid (5) Phosphatidylethanolamine (6) Phosphatidylserine (7) Erythorbic acid (8) Salt of Erythorbic acid (9) Guaiac butter (10) Nordihydroguaiaretic acid (11) Salt of nordihydroguaiaretic acid (12) Propyl gallate is extremely safe and stable, and has a sufficient whitening effect. This was recognized and the present invention was completed.

That is, the present invention is a whitening agent characterized by containing one or more of the above compounds as active ingredients.

The configuration of the present invention will be described below.

The compounds used in the present invention are (1) sezamol (2) lecithin (3) phytic acid (4) salts of phytic acid (5) phosphatidylethanolamine (6) phosphatidylserine (7) erythorbic acid (8) Erythorbic acid salt (9) Guaiac butter (10) Nordihydroguaiaretic acid (11) Nordihydroguaiaretic acid salt (12) Propyl gallate, phytic acid, erythorbic acid, nordihydroguaiaretic acid Salts include sodium salts and potassium salts. These compounds can be blended into a whitening agent by following the method of blending general fat-soluble compounds.

One or more of these compounds are appropriately selected and blended. The blending amount can be selected as appropriate depending on the desired dosage form, but it is usually 0.0% as a dry solid content based on the total amount of the composition.
The amount is about 0.05 to 15% by weight, preferably about 0.1 to 10% by weight. If it is less than 0.005% by weight, the effect tends to be poor, and conversely, if it is added in excess of 15% by weight, no significant increase in the effect can be expected.

The whitening agent of the present invention can be in the form of an emulsion type, a solubilized type, a dispersion type, a film type, a soap, an ointment, and the like.

In addition to the above-mentioned essential ingredients, the skin whitening agent of the present invention may optionally contain oil, ultraviolet absorbers, surfactants, preservatives, humectants,
Flavors, water, alcohol, thickeners, coloring agents, etc. can be added as appropriate.

[Effects of the present invention] In order to clarify the whitening effect of the whitening agent of the present invention, the following experimental examples are shown.

(Experimental Example) Low Shicon was manufactured by a conventional method based on the formulation shown in Table 1, and its whitening effect was measured.

A panel of 110 women between the ages of 25 and 42 who had spots, freckles, etc. on their faces were divided into groups of 10 for 118 yen each, and each lotion containing each ingredient was applied to their faces once a day for 3 months. The whitening effect after use was evaluated based on the following criteria.

(Judgment criteria) Significant results: Pigmentation became less noticeable.

The effective two-color deposit became much thinner.

Slightly effective two-color deposit became slightly thinner.

There was no change in the two-color deposit.

(Judgment) A: When the proportion of subjects showing excellent response and efficacy is 80% or more B: The proportion of subjects showing excellent response and efficacy is 50-8
0% case C: The proportion of subjects showing marked response and efficacy is 50% or less The results are shown in Table 1.

As is clear from Table 1, the whitening agent of the present invention has an excellent whitening effect. Furthermore, no skin irritation or sensitization was observed, and it was found to be highly safe.

(The following is a blank space) [Example] Next, the present invention will be explained in detail with reference to Examples. The present invention is not limited thereby. The blending amount is in weight%.

Example 1 Vanishing cream Stearic acid 5.0 Stearyl alcohol 4.0 Stearic acid butyl alcohol ester 8.0 Glycerin monostearate 2.0 Lecithin
1.0 Propylene Glycol 10.0 Glycerin
4.0 caustic potash
0.2 preservatives/antioxidants
Appropriate amount of fragrance
Appropriate amount of ion exchange water
Residue (manufacturing method) Add propylene glycol and caustic potash to ion-exchanged water, dissolve, heat, and maintain at 700C (water phase). Mix other ingredients, heat and melt and keep at 70°C (oil phase). Gradually add the oil phase to the water phase, and after all addition is complete, maintain the temperature for a while to allow the reaction to occur. Then, emulsify the mixture uniformly using a homomixer, stir well, and cool to 30°C.

Example 2 Neutral Cream Stearyl Alcohol 7.0 Stearic Acid 2.0 Hydrogenated Lanolin
2,0 squalane
5.02-Octyldodecyl alcohol
6.0 Polyoxyethylene (25 moles) Cetyl alcohol ether 3.0 Glycerin monostearate 2.0 Phosphatidylserine 1.5 Propylene glycol
5.0 Fragrance Appropriate amount Preservative/Antioxidant Appropriate amount Ion-exchanged water Remainder (manufacturing method) Add propylene glycol to ion-exchanged water and heat.7
Keep at 0°C (aqueous phase). Mix other ingredients and heat and melt 7.
Keep at 0°C (oil phase). The oil phase is pre-emulsified by adding the oil phase to the water phase, uniformly emulsified using a homomixer, and then cooled to 30°C while stirring well.

Example 3 Cold cream solid paraffin 5.0 Hitsuwa 10.0 Vaseline
15.0 Liquid paraffin
41.0 Glycerin monostearate 2.0 Polyoxyethylene (20 mol) Sorbitan monolaurate 2.0 Phosphatidylethanolamine 1.0 Soap powder
0.1 borax
0.2 fragrance
Appropriate amount of preservative/antioxidant Appropriate amount of ion-exchanged water Residue (manufacturing method) Add soap powder and borax to ion-exchanged water, heat and dissolve.
Keep at °C (aqueous phase). Mix the other ingredients and heat and melt for 70 minutes.
Keep at °C (oil phase). The oil phase is gradually added to the water phase while stirring to carry out the reaction. After the reaction is completed, the mixture is uniformly emulsified using a homomixer, and after the emulsification is cooled to 30°C.

Example 4 Emulsion Stearic acid 2.5 Cetyl alcohol 1.5 Vaseline
5.0 liquid paraffin
10.0 Polyoxyethylene (10 mol) Monooleic acid ester 2.0 Polyethylene glycol 1500 3.0 Triethanolamine 1.0 Phytic acid
0.5 Phosphatidylethanolamine 1.0 Fragrance
Appropriate amount of preservative/antioxidant Appropriate amount of ion-exchanged water Remaining (manufacturing method) Add polyethylene glycol 1500 and triethanolamine to ion-exchanged water, dissolve by heating, and keep at 70°C (water phase). Mix other ingredients, heat and melt and keep at 70°C (oil phase). The oil phase is pre-emulsified by adding the oil phase to the water phase, and the mixture is uniformly emulsified using a homomixer. After emulsification, the mixture is cooled to 30°C while stirring well.

Example 5 Emulsion Microcrystalline Wax 1.0 Mitsuwax
2.0 lanolin
20.0 liquid paraffin
10.0 Squalane
5.0 Sorbitan sesquioleate 4.0 Polyoxyethylene (20 mol) Sorbitan monooleate 1.0 Phytic acid 3.0 Propylene glycol 7.0 Fragrance
Appropriate amount of preservatives and antioxidants
Appropriate amount of ion-exchanged water Remaining (manufacturing method) Add propylene glycol to ion-exchanged water and heat.
Keep at 0°C (aqueous phase). Mix other ingredients and heat to dissolve 7.
Keep at 0°C (oil phase). While stirring the oil phase, gradually add the water phase to it and uniformly emulsify with a homomixer. After emulsification, cool to 30°C while stirring well.

Example 6 Lotion (alcohol phase) 95% ethyl alcohol 10.0 Polyoxyethylene (60 mol) Hydrogenated castor oil 2.0 Propylene glycol 4.0 Oleyl alcohol 0. Lucitin
2.5 (Aqueous phase) Glycerin 5.0 Ultraviolet absorber Appropriate amount of ion-exchanged water
Residue (manufacturing method) Solubilize after adjusting the aqueous phase and alcohol phase.

Example 7 Beer-off type pack (alcohol phase) 95χ ethanol 10.0 Polyoxyethylene (15 mol) Oleyl alcohol ether 2.0 Sezamol 5.0 Preservative
Appropriate amount of fragrance
Appropriate amount (aqueous phase) Polyvinyl alcohol 12.0 Glycerin 3.0 Polyethylene glycol 1500 1.0 Ion exchange water
Residue (manufacturing method) Adjust the aqueous phase at 80°C and cool to 50°C. After adding the alcohol phase prepared at room temperature, the mixture is evenly mixed and allowed to cool.

Claims (1)

[Scope of Claims] A whitening agent characterized by containing one or more selected from the following compounds. (1) Sezamol (2) Lecithin (3) Phytic acid (4) Salt of phytic acid (5) Phosphatidylethanolamine (6) Phosphatidylserine (7) Erythorbic acid (8) Salt of Erythorbic acid (9) Guaiac fat (10) Nordihydroguaiaretic acid (11) Salt of nordihydroguaiaretic acid (12) Propyl gallate