CN110403834A - A kind of eye-care liposome and preparation method thereof - Google Patents

Abstract

The invention belongs to cosmetic technical fields, and in particular to a kind of eye-care liposome and preparation method thereof.The eye-care liposome includes the component of following mass percentage: 1-10% hydrolecithin, 1-10%PEG-40 rilanit special, 0.1-1.0% octyl dodecanol, the South America 1-10% amaranth root extract, 1-5% soybean lecithin, 1-10% Ba Xi Huang Huang ebon bark extract, the 0.5%HA sodium hyaluronate of 1-10%, 1-5% Madonna lily extract, 1-10% glycerol, 1-10% butanediol, 0.1-1.0%DMDMH, surplus are deionized water.Various eye edema are eliminated, and there is the effect of anti-ageing, to improve skin and modification face mask especially suitable for improving black eye with antiallergic and immunoregulatory activities.Active constituent therein can break through skin barrier, and absorptivity is high, and improvement is significant.

Description

A kind of eye-care liposome and preparation method thereof

Technical field

The present invention relates to a kind of eye-care compositions more particularly to a kind of eye-care liposome and preparation method thereof.

Background technique

The face of people is to be most susceptible to years influence, shows the region of aging, and eye is as most sensitive region It is more vulnerable to the erosion of external environment, along with current rhythm of life and operating pressure influence, has more than the human eye of one third There is the problems such as various, mainly to concentrate on black eye and upper and lower palpebral edema eye pouch in portion, this is because Eye socket peripheral region has a large amount of vascular tissue, vulnerable to inherent and external factor influence, is damaged, and influences that eye is micro- to follow Ring causes a series of yellowish-brown pigment to deposit in epidermis, forms black eye.And there are many fat are thin for palpebral region up and down Born of the same parents form eye pouch often due to abnormal eyelid protrusion that moisture and lipid accumulation are formed, and palpebra inferior region due to The blood vessel that there are many distributions is also easy to form blood, pigment deposition, influences personal beauty.Therefore, a kind of effective eye is developed Portion's care product is very necessary.

Summary of the invention

The purpose of the present invention is deficiency in view of the above technology, a kind of eye-care liposome and preparation method thereof is provided, The problems such as effectively solving black eye, fatty eye pouch and eye wrinkle-removing.

In order to achieve the goal above, the present invention adopts the following technical scheme:

The first aspect of the invention is to provide a kind of eye-care liposome, the group including following mass percentage Point: 1-10% hydrolecithin, 1-10%PEG-40 rilanit special, 0.1-1.0% octyl dodecanol, the South America 1-10% amaranth root Extract, 1-5% soybean lecithin, 1-10% Ba Xi Huang Huang ebon bark extract, the 0.5%HA sodium hyaluronate of 1-10%, 1-5% Madonna lily extract, 1-10% glycerol, 1-10% butanediol, 0.1-1.0%DMDMH, surplus are deionized water.

Preferably, eye-care liposome of the invention includes the component of following mass percentage: 3-6% hydrogenates lecithin Rouge, 3-6%PEG-40 rilanit special, 0.5-1.0% octyl dodecanol, the South America 3-6% amaranth root extract, 1-2% soybean ovum Phosphatide, 3-6% Ba Xi Huang Huang ebon bark extract, the 0.5%HA sodium hyaluronate of 1-5%, 1-3% Madonna lily extract, 3-6% Glycerol, 3-6% butanediol, 0.1-0.5%DMDMH, surplus are deionized water.

It is highly preferred that eye-care liposome of the invention includes the component of following mass percentage: 4% hydrogenation lecithin Rouge, 5%PEG-40 rilanit special, 0.8% octyl dodecanol, 5% South America amaranth root extract, 1.6% soybean lecithin, 5% Ba Xi Huang Huang ebon bark extract, 3% 0.5%HA sodium hyaluronate, 2.5% Madonna lily extract, 5% glycerol, 5% fourth two Alcohol, 0.3%DMDMH, surplus are deionized water.

The second aspect of the invention is to provide a kind of method for preparing above-mentioned eye-care liposome, including following step It is rapid:

Step 1

By 1-10% hydrolecithin, 1-5% soybean lecithin, 0.1-1.0% octyl dodecanol, 1-10% glycerol, 1- 10%0.5%HA, water, 0.1-1.0%DMDMH are uniformly mixed at 60 degree, and above-mentioned composition is component A；

Step 2

Water, 1-10% butanediol, 1-10%PEG-40 rilanit special, the South America 1-10% amaranth root extract, 1-10% bars Xi Huang Huang ebon bark extract, 1-5% bermuda lily flower extract are uniformly mixed at 60 degree, and above-mentioned composition is component B；

Step 3

AB component is passed through into super-voltage micro jet homogenizer 30000PSI, 5-10 circulation after mixing；

Step 4

Uniform and stable liposome is finally obtained by obtained solution by polycarbonate membrane using extrusion equipment.

South America amaranth (pfaffiapaniculata) root extract also known as pfaffia are Amaranthaceae genus Pfaffia plant, former The place of production is South America, and main product is introduced a fine variety in Brazil, China in Guangxi.Perennial herb, stem are crawled, and rhizome is coarse, main to be distributed In Brazilian Ge Yiyasi (Goias) ecosystem area of South America tropical rainy climate band.Sweet in flavor, slight bitter, warm nature.Cosmetics are adopted With the extract of its herb.

Wooden (Muira Puama) bark extract of Ba Xi Huang Huang, Ba Xi Huang Huang wood is born at forest hillside, general to be only distributed In tropical rainy country, source area Malaysia；For evergreen dungarunga, about 15 meters high, sprout then has branch without branch, veteran, Root is faint yellow.Ba Xi Huang Huang ebon bark extract is brown color fine powder, is rich in saponin(e and flavonoids active material.

Madonna lily (White lily) extract, perennial herb are 60~100 centimetres high.Bulb is spherical, white, meat Matter, apex is normally opened to be put such as lotus shape, and stem is upright, cylindrical, often there is brown purple spot.Below raw most fibrous roots.Extract packet Containing lily bulb containing a variety of alkaloids and starch, protein, fat etc. such as colchicins.

Compared with prior art, the invention has the following advantages:

1. liposome membrane ingredient be similar to cell membrane, therefore have better absorption, to wrapped up in film activity at Dividing has better protective effect.

2. being wrapped up using pure plant extracts as active constituent, safety and biocompatibility are better than chemicals Matter.

3.Pfaffia Paniculata (South America amaranth), Ptychoprtalum Olacoides (Ba Xi Huang Huang wood) and It is rich in saponin(e and flavonoids active material in White lily (Bai Baihe), there are antiallergic and immunoregulatory activities, it is particularly suitable In improving black eye, various eye edema are eliminated, and there is the effect of anti-ageing, to improve skin and modification face mask.But directly In cosmetics, active constituent therein is difficult to break through skin barrier, causes absorptivity not high, improvement is limited.Thus We are amphipathic using phospholipid molecule, and using super-voltage micro jet nano-dispersed technology, vegetable active object is wrapped in phosphatide In molecular layer, prepares physicochemical properties and stablize, and there is the novel rouge for the problems such as improving black eye and various eye edema Plastid considerably increases absorptivity, hence it is evident that improves product efficacy.

Specific embodiment

Following embodiment further illustrates the contents of the present invention, but should not be construed as limiting the invention.If not especially It indicates, the conventional means that technological means used in embodiment is well known to those skilled in the art, raw material used in the present invention It is commercial product.

Test result is as follows table 1

The method for preparing the eye-care liposome of embodiment 1-3 composition, comprising the following steps:

Step 1: by hydrolecithin, soybean lecithin, octyl dodecanol, glycerol, 0.5%HA, water, DMDMH at 60 degree It is uniformly mixed, above-mentioned composition is component A；

Step 2: water, butanediol, Cremophor RH40,5% South America amaranth root extract, 5% Ba Xi Huang Huang ebon skin Extract, bermuda lily flower extract are uniformly mixed at 60 degree, and above-mentioned composition is component B；

Step 3: AB component is passed through into super-voltage micro jet homogenizer 30000PSI, 5-10 circulation after mixing；

Step 4: using extrusion equipment, by obtained solution by polycarbonate membrane, finally obtains uniform and stable rouge Plastid.

Comparative example 1

The preparation method is the same as that of Example 1, and material composition only lacks South America amaranth root extract, other compositions and the same embodiment of ratio 2。

Comparative example 2

The preparation method is the same as that of Example 1, and material composition only lacks Ba Xi Huang Huang wood extract, other compositions and ratio with implementation Example 2.

Comparative example 3

The preparation method is the same as that of Example 1, and material composition only lacks Madonna lily extract, other compositions and the same embodiment of ratio 2。

Test case 1: the whitening function of periocular area

Reagent and material: use for laboratory water, using the tertiary effluent in GB/T6682；In embodiment 1-3 and comparative example 1-3 Eye-care liposome；Chipless water-absorbing dry paper handkerchief.

Test equipment:

The German Gartner Bi Ke (Byk Gardner) chromascope；Assay balance, precision 0.0001g；

Test condition:

20 DEG C -22 DEG C of environment temperature, relative humidity 40-60% of test, and carry out real-time dynamic monitoring；

The test conditions such as tester, place, instrument in test process are consistent.

Test method:

Number of subjects is 30 people, and test position is black eye collar region, and every time before test, subject uniformly cleans tested portion Position, and blotted with chipless water-absorbing dry paper handkerchief.

It is required that product is smeared uniformly；The left and right circumference of eyes of random arrangement is tested area, and subject applies one in each daily morning and evening Secondary, service life is 28 days.Within test period, recipient site does not use other any cosmetics.

Test result is as follows table 2

Group	ITA ° of black eye area increase percentage (%)	Black eye region glossiness L increment rate (%)
			Embodiment 1	115%	3.0
Embodiment 2	120%	3.2
			Embodiment 3	110%	3.1
Comparative example 1	23%	0.60
			Comparative example 2	30%	0.52
Comparative example 3	22%	0.48

Illustrate: ITA ° (color individual type angle) is a parameter for reflecting the colour of skin, and ITA ° of value is bigger, and the colour of skin is more shallow, says The whitening effect of bright product is more obvious.Another parameter L (Luminosity) indicates skin shine, the bigger explanation of value Whitening effect is more obvious.

As shown in Table 2,1-3 of the embodiment of the present invention to dispel black eye and increase skin shine have remarkable result, especially The effect of embodiment 2 is more significant.And comparative example 1-3 is due to lacking certain ingredients in inventive formulation, using effect is equal Not as good as embodiment 1-3, illustrate what eye-care liposome formula of the invention was obtained not by the simple combination of each component, Further illustrate there is synergistic effect between inventive formulation each component.

Test case 2:

Test condition:

Target number of cases: 180 triers are selected, are divided into 6 groups, every group of 30 people.

Experimental design: being respectively adopted the eye-care liposome in embodiment 1-3 and comparative example 1-3, and observation and impression make Use effect.

Application method: after subject cleans face, taking the eye-care liposome of grain of rice size, dub in circumference of eyes, With finger pulp, along eye circumference, gently bullet is clapped until thoroughly absorbing.It is each using once daily morning and evening, adhere to using one month.

Black eye of dispelling tests assessment result such as the following table 3:

Group	It is excellent	It is good	Generally	It is poor
					Embodiment 1	25	5
Embodiment 2	27	3
					Embodiment 3	23	7
Comparative example 1		7	6	17
					Comparative example 2		6	9	15
Comparative example 3		6	11	13

Eye pouch of dispelling tests assessment result such as the following table 4:

Illustrate: by table 3,4 it is found that the numerous subjects' of eye-care liposome of 1-3 of the embodiment of the present invention likes and recognize Can, subject indicates that nursing liposome Vitamin K and eye pouch effect of dispelling of the invention are good, and easily absorbs, and have anti- The effect of declining, improving skin and modification face mask.The effect of especially embodiment 2 is more significant.

It will also realize that by table 3,4, comparative example 1-3, due to lacking certain groups in eye-care liposome formula of the invention Point, using effect is not so good as embodiment 1-3, illustrates eye-care liposome formula of the invention not by each component What simple combination obtained, further illustrate there is synergistic effect between inventive formulation each component.

Specific embodiments of the present invention are described in detail above, but it is merely an example, the present invention is simultaneously unlimited It is formed on particular embodiments described above.To those skilled in the art, any couple of present invention carries out equivalent modifications and Substitution is also all among scope of the invention.Therefore, without departing from the spirit and scope of the invention made by equal transformation and Modification, all should be contained within the scope of the invention.

Claims (4)

1. a kind of eye-care liposome, which is characterized in that the component including following mass percentage: 1-10% hydrogenates lecithin Rouge, 1-10%PEG-40 rilanit special, 0.1-1.0% octyl dodecanol, the South America 1-10% amaranth root extract, 1-5% soybean Lecithin, 1-10% Ba Xi Huang Huang ebon bark extract, the 0.5%HA sodium hyaluronate of 1-10%, 1-5% Madonna lily extract, 1-10% glycerol, 1-10% butanediol, 0.1-1.0%DMDMH, surplus are deionized water.

2. eye-care liposome according to claim 1, which is characterized in that the group including following mass percentage Point: 3-6% hydrolecithin, 3-6%PEG-40 rilanit special, 0.5-1.0% octyl dodecanol, the South America 3-6% amaranth root mention Take object, 1-2% soybean lecithin, 3-6% Ba Xi Huang Huang ebon bark extract, the 0.5%HA sodium hyaluronate of 1-5%, 1-3% white hundred Flower extract is closed, 3-6% glycerol, 3-6% butanediol, 0.1-0.5%DMDMH, surplus is deionized water.

3. eye-care liposome according to claim 2, which is characterized in that the group including following mass percentage Point: 4% hydrolecithin, 5%PEG-40 rilanit special, 0.8% octyl dodecanol, 5% South America amaranth root extract, 1.6% Soybean lecithin, 5% Ba Xi Huang Huang ebon bark extract, 3% 0.5%HA sodium hyaluronate, 2.5% Madonna lily extract, 5% Glycerol, 5% butanediol, 0.3%DMDMH, surplus are deionized water.

4. a kind of method for preparing any eye-care liposome of claim 1-3, which is characterized in that including following step It is rapid:

Step 1

Hydrolecithin, soybean lecithin, octyl dodecanol, glycerol, 0.5%HA, water, DMDMH are uniformly mixed at 60 degree, on Stating composition is component A；

Step 2

Water, butanediol, Cremophor RH40, South America amaranth root extract, Ba Xi Huang Huang ebon bark extract, bermuda lily Extract is uniformly mixed at 60 degree, and above-mentioned composition is component B；

Step 3

AB component is passed through into super-voltage micro jet homogenizer 30000PSI, 5-10 circulation after mixing；

Step 4

Uniform and stable liposome is finally obtained by obtained solution by polycarbonate membrane using extrusion equipment.