CN106726917B - A kind of eyeware products and solution for lenses and contact lenses - Google Patents
A kind of eyeware products and solution for lenses and contact lenses Download PDFInfo
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- CN106726917B CN106726917B CN201611162852.6A CN201611162852A CN106726917B CN 106726917 B CN106726917 B CN 106726917B CN 201611162852 A CN201611162852 A CN 201611162852A CN 106726917 B CN106726917 B CN 106726917B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
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Abstract
The present invention provides a kind of eyeware products and solution for lenses and contact lenses, including Gotu Kola P.E, purple ball algae extract, corn poppy's extract, moisturizer, oily matter, surfactant, alcohols material, gel-type vehicle, pH adjusting agent, wetting agent and water.Compared with prior art, effect ingredient in eyeware products and solution for lenses and contact lenses provided by the invention is Gotu Kola P.E, purple ball algae extract and corn poppy's extract, Gotu Kola P.E, purple three kinds of ingredients of ball algae extract and corn poppy's extract synergistic effect under, make eyeware products and solution for lenses and contact lenses provided by the invention that can dramatically increase the elasticity of skin, it effectively solves the problems, such as the eye skins such as black eye, eye pouch, wrinkle, and also has the function of improving fat granule and edema；Cooperate the other compositions in eyeware products and solution for lenses and contact lenses simultaneously, makes eyeware products and solution for lenses and contact lenses provided by the invention that there is preferable moistening effect, can be improved eye part skin moisture.
Description
Technical field
The present invention relates to cosmetic technical field more particularly to a kind of eyeware products and solution for lenses and contact lenses.
Background technique
Eye part skin is position or even the smile, these faces of frowning of the most delicate part of human skin and most fragile
Expression all can cause eye eye pouch, crow's feet occur.Moreover, in the modern life, the appearance of more and more electronic products is enriched
The colorful network life, late into the night overtime work, operating pressure increase, too early using factors such as cosmetics, cosmetics quality problem, agings
The eye skins problems such as caused black eye, canthus line, eye pouch, edema are further serious.Eye part skin aging can make a people
Makings is had a greatly reduced quality, and people is allowed to seem aged wan and sallow, lassitude.The eye skin care for having the effects that anti-oxidant, nti-freckle, anti-wrinkle
Product or these symptoms can reduce using massage, the injection means such as beauty product to eye skin.
Currently, all kinds of eyeware products and solution for lenses and contact lenses are essentially all the various reasons that basis causes eye skin problem on the market,
Solution targetedly is taken, such as supplements eye part skin nutrition using various nutritive additives, tightens eye flesh
Skin makes the temporary recovery elasticity of eye skin and reduces wrinkle, delay skin aging.Though common eye skin care item add many battalion
Active constituent is supported, but effect is very unsatisfactory, nutritional ingredient is deposited on eye part skin, is born to skin tape, is caused allergy
Or extra fat granule is generated, and fat granule is difficult to eliminate once generating in the short time.
The eye skin care item that the prior art provides are difficult to solve the eyes such as black eye, crow's feet, eye pouch, microgroove, fat granule
Problem, therefore in order to meet consumer demand, urgent need develops a kind of safely and effectively eye skin care item.
Summary of the invention
In view of this, eye-care provided by the invention produces the purpose of the present invention is to provide a kind of eyeware products and solution for lenses and contact lenses
Product can effectively solve the problem that eye part skin problem.
The present invention provides a kind of eyeware products and solution for lenses and contact lenses, including Gotu Kola P.E, purple ball algae extract, corn poppy's extraction
Object, moisturizer, oil, surfactant, cosurfactant, gel-type vehicle, pH adjusting agent, wetting agent and water.
Preferably, mass content of the Gotu Kola P.E in eyeware products and solution for lenses and contact lenses is 1~6%.
Preferably, mass content of the purple ball algae extract in eyeware products and solution for lenses and contact lenses is 1~5%.
Preferably, mass content of the corn poppy's extract in eyeware products and solution for lenses and contact lenses is 0.5~1.5%.
Preferably, it is poly- to be selected from acetyl group tetrapeptide -5, ethoxy urea, ceramide, Sodium Hyaluronate, fruit for the moisturizer
One or more of sugar, allantoin, reed fragrant plant oil, D-sorbite and glycine betaine.
Preferably, the oil is selected from olive oil, ethyl oleate, caprylic/capric triglyceride, isopropyl myristate, suddenly
One or more of bar oil and vitamin E suddenly.
Preferably, the surfactant is in Tween-80, Tween-40, Emulsifier EL-60 and soybean lecithin
It is one or more of.
Preferably, the cosurfactant is selected from polyethylene glycol or propylene glycol.
Preferably, the gel-type vehicle is selected from carbomer, xanthan gum, seaweed glue, chitosan, Arabic gum or Caesalpinia spinosaKuntze
Glue.
Preferably, the pH adjusting agent is selected from triethanolamine and/or citric acid.
Compared with prior art, effect ingredient in eyeware products and solution for lenses and contact lenses provided by the invention is Gotu Kola P.E, purple
Ball algae extract and corn poppy's extract, in Gotu Kola P.E, purple three kinds of ingredients of ball algae extract and corn poppy's extract
Under synergistic effect, make eyeware products and solution for lenses and contact lenses provided by the invention that can dramatically increase the elasticity of skin, effectively solution black eye, eye
The eye skins problem such as bag, wrinkle, and also have the function of improving fat granule and edema；Cooperate in eyeware products and solution for lenses and contact lenses simultaneously
Other compositions, make eyeware products and solution for lenses and contact lenses provided by the invention have preferable moistening effect, can be improved eye part skin moisture.
Mentioned component is preferably prepared into nano-emulsion gel products by the present invention, compared with Common hydrogels, nano-emulsion gel
Have with skin and preferably couple and hydration effect, good biocompatibility, can long period and site of action tight adhesion, dispersion is
It is even, be conducive to fully absorbing for active constituent, to improve its bioavilability.
Specific embodiment
The technical scheme in the embodiments of the invention will be clearly and completely described below, it is clear that described implementation
Example is only a part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, this field is common
Technical staff's every other embodiment obtained without making creative work belongs to the model that the present invention protects
It encloses.
The present invention provides a kind of eyeware products and solution for lenses and contact lenses, including Gotu Kola P.E, purple ball algae extract, corn poppy's extraction
Object, moisturizer, oil, surfactant, cosurfactant, gel-type vehicle, pH adjusting agent, wetting agent and water.
In the present invention, there is the Gotu Kola P.E clearing heat and detoxicating, inducing diuresis and reducing edema, nourishing, anti-inflammatory, quelling to make
With, can stimulate deep skin cell substitute；Gotu Kola P.E contains there are many triterpene compound, includes α-amyrin knot
Structure, main component be Asiaticoside, asiatic acid and brahmic acid, additionally containing ursolic acid, cupreol, palmitinic acid,
Succinic acid, caffeic acid, ferulic acid, choline, vitamin C and stachyose, can compact epidermis and corium coupling part, skin can be made
It limbers up, helps to solve cutis laxa phenomenon, make the flexible formation for promoting collagen in skin corium of skin smooth, make fibre
Fibrillarin regeneration, achievees the effect that skin compact smooth, can also help impaired organization healing and consolidation skin.Centella mentions
It takes object that can promote the close connection between epidermis and corium and inhibits the increase of fat cell, prevent hydroderma, occur
It is fat.The present invention does not have special limitation to the source of the Gotu Kola P.E, can be bought and be obtained by market.
In the present invention, mass content of the Gotu Kola P.E in eyeware products and solution for lenses and contact lenses is preferably 1~6%, more
Preferably 2~5%, most preferably 3~4%.
In the present invention, the purple ball algae extract contains low oligosaccharide and necessary microelement, can help to shrink quiet
Arteries and veins and Dermal microvessel improve the symptoms such as red capillary, inflammation, black eye, oedema, leg be heavy, while promoting Skin Cell again
It is raw, improve skin appearance.The present invention does not have special limitation to the source of the purple ball algae extract, can be bought and be obtained by market
?.
In the present invention, mass content of the purple ball algae extract in eyeware products and solution for lenses and contact lenses is preferably 1~5%, more
Preferably 2~4%, most preferably 3%.
In the present invention, corn poppy's extract spends seed from corn poppy, can be by inhibiting glycerol-3-phosphate de-
The activity of hydrogen enzyme come prevent fat generation, promote the release of free fatty acid, reduce the size of fat cell, decompose subcutaneous rouge
Fat improves the form and texture of skin surface, reduces " orange peel " phenomenon, prevents pathologic cellulite and formed.The present invention is to institute
The source for stating corn poppy's extract does not have special limitation, can be bought and be obtained by market.
In the present invention, mass content of the corn poppy's extract in eyeware products and solution for lenses and contact lenses be preferably 0.5~
1.5%, more preferably 0.8~1.2%, most preferably 1%.
Gotu Kola P.E, purple ball algae extract and corn poppy's extract are used cooperatively by the present invention, play synergy
Effect, there is eye haustra -dsipelling, wrinkle, black-eyed good result to eye skin, and can effectively improve edema, fat granule
Etc. symptoms.
In the present invention, the moisturizer has preferable moisture-keeping function, plays and improves eye part skin moisture and lasting lock
The effect of water.In the present invention, the moisturizer is preferably selected from acetyl group tetrapeptide -5, ethoxy urea, ceramide, hyaluronic acid
One or more of sodium, levulan, allantoin, reed fragrant plant oil, D-sorbite and glycine betaine.The present invention carrys out the moisturizer
Source does not have special limitation, can be bought and be obtained by market.In the present invention, quality of the moisturizer in eyeware products and solution for lenses and contact lenses
Content is preferably 2~7%, and more preferably 3~6%, most preferably 4~5%.
In the present invention, it is different to be preferably selected from olive oil, caprylic/capric triglyceride, ethyl oleate, myristic acid for the oil
One or more of propyl ester, jojoba oil and vitamin E.The present invention does not have special limitation to the source of the oil, can be by
Market purchase obtains.In the present invention, mass content of the oil in eyeware products and solution for lenses and contact lenses is preferably 1~4.5%, more preferably
It is 2~4%, most preferably 3%.
In the present invention, the surfactant is preferably selected from Tween-80, Tween-40, Emulsifier EL-60 and soybean
One or more of phosphatide.The present invention does not have special limitation to the source of the surfactant, can be bought and be obtained by market
?.In the present invention, mass content of the surfactant in eyeware products and solution for lenses and contact lenses is preferably 10~25%, more preferably
15~20%, most preferably 18%.
In the present invention, the cosurfactant is preferably selected from polyethylene glycol or propylene glycol, more preferably polyethylene glycol
400.The present invention does not have special limitation to the source of the cosurfactant, can be bought and be obtained by market.In the present invention,
Mass content of the cosurfactant in eyeware products and solution for lenses and contact lenses is preferably 5~10%, and more preferably 6~9%, most preferably
It is 7~8%.
In the present invention, the gel-type vehicle be preferably selected from carbomer, xanthan gum, seaweed glue, chitosan, Arabic gum or
Tara gum.The present invention does not have special limitation to the source of the gel-type vehicle, can be bought and be obtained by market.In the present invention
In, mass content of the gel-type vehicle in eyeware products and solution for lenses and contact lenses is preferably 0.1~0.6%, and more preferably 0.2~0.5%,
Most preferably 0.3~0.4%.
In the present invention, the pH adjusting agent is preferably selected from triethanolamine and/or citric acid.The present invention adjusts the pH
The source of agent does not have special limitation, can be bought and be obtained by market.It is special that the present invention does not have the dosage of the pH adjusting agent
Limitation, range of the pH value for the eyeware products and solution for lenses and contact lenses that the dosage of pH adjusting agent enables to 5~7.
In the present invention, the wetting agent is for soaking gel-type vehicle, preferably glycerol.In the present invention, the wetting
Mass content of the agent in eyeware products and solution for lenses and contact lenses is preferably 3~9%, and more preferably 4~8%, most preferably 5~7%.
The present invention does not have special limitation, preferably deionized water, those skilled in the art to the type and dosage of the water
Member can select the water of addition Optimum Contents according to the actual situation.
Active constituent in eyeware products and solution for lenses and contact lenses provided by the invention is naturally safe, mild non-stimulated.
The eyeware products and solution for lenses and contact lenses of mentioned component is preferably prepared into nano-emulsion gel using nano-emulsion technology by the present invention.Nanometer
Cream is to be spontaneously formed by water, oil, surfactant and cosurfactant etc., is the Thermodynamically stable that partial size is 10~100nm, each
To the same sex, transparent or semitransparent homogeneous dispersion system.Nano-emulsion is easy through biomembrane, and percutaneous abilities are good, can be in skin
The reservoir of effective component is formed, realizes the effect of targeting, sustained release.1) nano-emulsion system, which has the advantage that, can increase activity
The solubility of ingredient；2) storage cavern of effective component is quickly formed on the skin, and is allowed to be formed according to gradient penetration rule by height
To low, passive target effect and sustained-release and controlled release effect from outside to inside reach efficiently release and remarkable result；3) nano-emulsion can be
It is prepared under the conditions of 25 DEG C or so of temperature, heat labile active constituent can be protected；4) nano-emulsion itself also certain antibacterial action,
Not needing addition chemical preservative, to prevent product rotten；5) nano-emulsion system has lower surface tension, is easy to soak
Skin makes the structure of cuticula change, thus can promote active constituent percutaneous absorbtion；6) with traditional lotion, cream phase
Than nano-emulsion has comfort when preferably aesthetic and use.
Nano-emulsion gel is that the water soluble polymers materials such as gelatin, cellulose, carbomer, poloxamer are added in nano-emulsion
Material forms transparent, stable reticular structure colloid.The viscosity of nano-emulsion can be improved in nano-emulsion gel, improves nano-emulsion and skin
The adhesiveness and stretchability of skin.Compared with Common hydrogels, nano-emulsion gel and skin, which have, preferably couple and hydration effect, is given birth to
Object compatibility is good, can long period and site of action tight adhesion, be uniformly dispersed, be conducive to fully absorbing for active constituent, from
And improve its bioavilability.
The eyeware products and solution for lenses and contact lenses of nano-emulsion gel form is able to solve stability common in cosmetics, ductility, absorption
Property it is bad the problems such as, and can be well protected the activity of active constituent, be conducive to its rapid osmotic and enter skin to be absorbed, send out
Bioactivity is waved, is used for a long time.The present invention utilizes nano-emulsion technology in gel, promotes effective component to enter skin, from basic
It is upper to solve the problems, such as eye skin.
In the present invention, the preparation method of the eyeware products and solution for lenses and contact lenses is preferred are as follows:
Gotu Kola P.E, corn poppy's extract, oil, surfactant and cosurfactant are mixed, obtained
Oily phase；
Purple ball algae extract, moisturizer and water are mixed, water phase is obtained；
Water phase is slowly added into oily phase, mixed liquor is obtained；
Gel-type vehicle and wetting agent are mixed into dispersion, obtain dispersion liquid；
Mixed liquor is added in dispersion liquid and is stood, pH adjusting agent is used to adjust pH as 5~7 to get nano-emulsion gel eye
Portion's care product.
In the present invention, the time of the standing is preferably 10~15 hours, and more preferably 12~13 hours.In the present invention
In, the Gotu Kola P.E, corn poppy's extract, moisturizer, oil, surfactant, helps surface-active at purple ball algae extract
Agent, gel-type vehicle, pH adjusting agent, centella is extracted described in type, source and the dosage and above-mentioned technical proposal of wetting agent and water
Object, purple ball algae extract, corn poppy's extract, moisturizer, oil, surfactant, cosurfactant, gel-type vehicle, pH tune
Section agent, wetting agent and the type of water, source are consistent with dosage, and details are not described herein.
The present invention, which combines nano-emulsion technology and gel, prepares eyeware products and solution for lenses and contact lenses, promotes each oil-soluble ingredients and water
Soluble components are solubilized into system well, the state for keeping the appearance of product still transparent, and functional component can be quickly by skin
It absorbs, has the function of targeting, sustained release.Eyeware products and solution for lenses and contact lenses is prepared into nano-emulsion gel by the present invention so that effective component is easy to
It is absorbed by the skin, has the function of targeting, sustained release, increase product provided by the invention by skin elasticity, effectively solve
The certainly eye skins problem of aging such as black eye, eye pouch, wrinkle, and improve fat granule and edema, while there is preferable moisturizing to imitate
Fruit improves eye part skin moisture.
The eyeware products and solution for lenses and contact lenses of nano-emulsion gel state, this eye shield is preferably prepared in the present invention according to the method described above
Managing product has good adhesiveness and stretchability, can be adhered to site of action for a long time, be uniformly dispersed, and it is fast to be conducive to functional component
Speed is absorbed by eye part skin, and bioavilability improves, and plays the effect of functional component to greatest extent；Nano-emulsion itself
With certain anti-microbial property, makes product provided by the invention without additional addition chemical preservative, reduce the stimulation to skin；
Nano-emulsion gel products have good solubilising, and oil-soluble and water-soluble active ingredient can be made to be well dissolved in system
In, make product appearance that pellucidity be presented, appearance is beautiful；Compared with lotion in the prior art, cream, nano-emulsion gel quality
Finer and smoother, skin sense is good, thermodynamics, dynamic stabilization, save for a long time it is not stratified, without precipitating；And it is provided by the invention
The preparation method of above-mentioned nano-emulsion gel is simple, and low energy consumption, can be completed at room temperature, therefore will not destroy activity in process
The activity of ingredient.
Raw material used in following embodiment of the present invention is commercial goods, and Gotu Kola P.E is bought in Guangzhou rising sun sail trade
Easy Co., Ltd；Purple ball algae extract, the purchase of corn poppy's extract are in hundred Hao Bo Co., Ltd of Guangzhou.
Embodiment 1
The ingredient of eyeware products and solution for lenses and contact lenses are as follows:
Gotu Kola P.E 1wt%, purple ball algae extract 3wt%, corn poppy's extract 1.5wt%, acetyl group tetrapeptide -5
2wt%, isopropyl myristate 1wt%, Emulsifier EL-60 10wt%, polyethylene glycol 400 5wt%, seaweed glue
0.6wt%, glycerol 9wt%, triethanolamine 0.8wt%, surplus are water.
Eyeware products and solution for lenses and contact lenses the preparation method comprises the following steps:
By Gotu Kola P.E, corn poppy's extract, isopropyl myristate, Emulsifier EL-60 and polyethylene glycol
400 are stirred at room temperature the oily phase of uniformly mixed conduct；Purple ball algae extract, acetyl group tetrapeptide -5 and water are stirred at room temperature mixed
It closes uniformly, as water phase；Then water phase is added slowly in oily phase while stirring, is stirred to clarify transparent；Seaweed glue is added
It soaks, is uniformly dispersed in glycerol, above-mentioned clear transparent solutions are then added, place 12h after mixing evenly, sufficiently after swelling, add
Enter triethanolamine to get nano-emulsion gel products.
Embodiment 2
The ingredient of eyeware products and solution for lenses and contact lenses are as follows:
Gotu Kola P.E 3.5wt%, purple ball algae extract 1wt%, corn poppy's extract 0.5wt%, ethoxy urea
1wt%, Cer EOS .5wt%, Sodium Hyaluronate 3wt%, olive oil 2wt%, ethyl oleate 0.5wt%, Tween-80
5wt%, soybean lecithin 10wt%, polyethylene glycol 400 7wt%, tara gum 0.2wt%, glycerol 6wt%, citric acid
0.3wt%, surplus are water.
Eyeware products and solution for lenses and contact lenses the preparation method comprises the following steps:
By Gotu Kola P.E, corn poppy's extract, olive oil, ethyl oleate, Tween-80, soybean lecithin and poly- second two
Alcohol 400, which is stirred at room temperature, to be uniformly mixed as oily phase；By purple ball algae extract, ethoxy urea, ceramide, Sodium Hyaluronate
Be stirred at room temperature with water it is uniformly mixed, as water phase；Then water phase is added slowly in oily phase while stirring, is stirred to clarify
It is transparent；Tara gum is added in glycerol and is soaked, is uniformly dispersed, above-mentioned clear transparent solutions is then added, put after mixing evenly
12h is set, sufficiently after swelling, citric acid is added to get nano-emulsion gel products.
Embodiment 3
The ingredient of eyeware products and solution for lenses and contact lenses are as follows:
Gotu Kola P.E 6wt%, purple ball algae extract 2wt%, corn poppy's extract 1wt%, reed fragrant plant oil 5wt%, fruit
Glycan 2wt%, jojoba oil 2wt%, vitamin E 1.5wt%, caprylic/capric triglyceride 1wt%, Tween-40
10wt%, Emulsifier EL-60 15wt%, propylene glycol 10wt%, carbomer 0.1wt%, glycerol 3wt%, triethanolamine
0.2wt%, surplus are water.
Eyeware products and solution for lenses and contact lenses the preparation method comprises the following steps:
By Gotu Kola P.E, corn poppy's extract, jojoba oil, vitamin E, caprylic/capric triglyceride, tween-
40, Emulsifier EL-60 and propylene glycol, which are stirred at room temperature, is uniformly mixed as oily phase；By purple ball algae extract, reed fragrant plant oil,
Levulan and water be stirred at room temperature it is uniformly mixed, as water phase；Then water phase is added slowly in oily phase while stirring, is stirred
To clear；Carbomer is added in glycerol and is soaked, is uniformly dispersed, above-mentioned clear transparent solutions is then added, stir evenly
After place 12h, sufficiently swelling after, be added triethanolamine to get nano-emulsion gel products.
Embodiment 4
The ingredient of eyeware products and solution for lenses and contact lenses are as follows:
Gotu Kola P.E 4wt%, purple ball algae extract 5wt%, corn poppy's extract 0.5wt%, D-sorbite
2wt%, glycine betaine 4wt%, olive oil 1.5wt%, vitamin E 2wt%, Emulsifier EL-60 8wt%, soybean lecithin
12wt%, propylene glycol 8wt%, xanthan gum 0.3wt%, glycerol 6wt%, triethanolamine 0.4wt%, citric acid 0.2wt%, surplus
For water.
Eyeware products and solution for lenses and contact lenses the preparation method comprises the following steps:
By Gotu Kola P.E, corn poppy's extract, olive oil, vitamin E, soybean lecithin, Emulsifier EL-60 and
Propylene glycol, which is stirred at room temperature, to be uniformly mixed as oily phase；At room temperature by purple ball algae extract, D-sorbite, glycine betaine and water
It is uniformly mixed, as water phase；Then water phase is added slowly in oily phase while stirring, is stirred to clarify transparent；By xanthan
Glue is added in glycerol and soaks, and is uniformly dispersed, above-mentioned clear transparent solutions are then added, place 12h after mixing evenly, is sufficiently swollen
Afterwards, citric acid is added to get nano-emulsion gel products.
Embodiment 5
The ingredient of eyeware products and solution for lenses and contact lenses are as follows:
Gotu Kola P.E 3wt%, purple ball algae extract 4wt%, corn poppy's extract 0.8wt%, acetyl group tetrapeptide -5
2wt%, Cer NP wt%, nutmeg isopropyl ester 2wt%, jojoba oil 2wt%, Tween-80 7wt%, soybean lecithin
10wt%, propylene glycol 6wt%, tara gum 0.4wt%, glycerol 7wt%, citric acid 0.3wt%, surplus are water.
Eyeware products and solution for lenses and contact lenses the preparation method comprises the following steps:
By Gotu Kola P.E, corn poppy's extract, nutmeg isopropyl ester, jojoba oil, soybean lecithin, Tween-80 and
Propylene glycol, which is stirred at room temperature, to be uniformly mixed as oily phase；Purple ball algae extract, acetyl group tetrapeptide -5, ceramide and water are existed
It is uniformly mixed at room temperature, as water phase；Then water phase is added slowly in oily phase while stirring, is stirred to clarify transparent；
Tara gum is added in glycerol and is soaked, is uniformly dispersed, above-mentioned clear transparent solutions is then added, place 12h after mixing evenly,
Sufficiently after swelling, citric acid is added to get nano-emulsion gel products.
Embodiment 6
The ingredient of eyeware products and solution for lenses and contact lenses are as follows:
Gotu Kola P.E 6wt%, purple ball algae extract 2wt%, corn poppy's extract 1wt%, reed fragrant plant oil 5wt%, fruit
Glycan 2wt%, carbomer 0.1wt%, glycerol 3wt%, triethanolamine 0.2wt%, surplus are water.
Eyeware products and solution for lenses and contact lenses the preparation method comprises the following steps:
Carbomer is added to the water, 85 DEG C is heated to, is evenly stirred until clear；Then cool down, be down to 45 to temperature
DEG C when, the reed fragrant plant oil, the levulan, glycerol that have been pre-mixed is added, stirs evenly；It is slowly dropped into triethanolamine, adjusts pH to 6；
It finally sequentially adds Gotu Kola P.E, purple ball algae extract and corn poppy's extract, stirring to make it completely dissolved, obtains eye
Care product.
Comparative example 1
The ingredient and preparation method of eyeware products and solution for lenses and contact lenses are same as Example 6, and difference is that being added without purple ball algae extracts
Object and corn poppy's extract, and the additional amount of Gotu Kola P.E is 9wt%.
Comparative example 2
The ingredient and preparation method of eyeware products and solution for lenses and contact lenses are same as Example 6, and difference is to be added without centella extraction
Object and corn poppy's extract, and the additional amount of purple ball algae extract is 9wt%.
Comparative example 3
The ingredient and preparation method of eyeware products and solution for lenses and contact lenses are same as Example 6, and difference is to be added without centella extraction
Object and purple ball algae extract, and the additional amount of corn poppy's extract is 9wt%.
Embodiment 7
Steady testing is carried out to the eyeware products and solution for lenses and contact lenses that the embodiment of the present invention 1~6 and comparative example 1~3 are prepared
1) centrifugal test: weighing appropriate product in centrifuge tube, and 4000rpm is centrifuged 30min, observes cosmetic variation.
2) low temperature resistant test: taking appropriate product, be placed in weighing bottle and seal, and is put into -20 DEG C of refrigerators, samples within every 7 days, continuously
It investigates 3 months, observes cosmetic variation.
3) heat resistant test: taking appropriate product, be placed in weighing bottle and seal, and is put into 60 DEG C of baking ovens, the observation of sampling in every 7 days,
It is continuous to investigate 3 months, observe cosmetic variation.
Testing result is, the nano-emulsion gel of Examples 1 to 5 preparation is not stratified through centrifugation, high temperature, low-temperature test, outside
Sight does not all change.Product prepared by embodiment 6 and comparative example 1~3 precipitates after being centrifuged, in -20 DEG C of environment
After placing 1 month, there is floccule, the clarification that appearance does not start to yet is bright, after being placed 1 month in 60 DEG C of environment, appearance
For thick white shape colloid.
Embodiment 8
Product Safety evaluation: human skin patch
Choosing 30 ages is the subject without skin disease allergies between 25-50 years old.Patch method: qualification is selected
Spot tester takes the embodiment of the present invention 1~6 of about 0.020~0.025g and comparative example 1~3 to make with closed patch experiment method
For standby product drop in spot tester, external application special adhesive tape is covered on subject back, and each subject pastes 9 spot testers, respectively
Product prepared by patch examination Examples 1 to 6 and comparative example 1~3, removes product after 24 hours, after removal respectively at 0.5,6,12,
24, observation dermoreaction in 48 hours records its result according to dermoreaction grade scale in " cosmetics health specification ".
Test result are as follows: human skin patch test result shows that each group subject passes through the patch test of each set product,
Illustrate product provided by the invention wherein 0 skin adverse reaction occurs in observation dermoreaction in 0.5,6,12,24,48 hour
It is non-stimulated using safe.
Embodiment 9
Black eye and the test of fat granule improvement:
180 25-50 years old fat granules and the serious experimenter of black eye are selected, are randomly divided into 9 groups, respectively using implementation
Eyeware products and solution for lenses and contact lenses prepared by example 1~6 and comparative example 1~3, application method are as follows: after cleaning face, the product of grain of rice size is taken to apply
It smears to eye surrounding, flicking absorbs, and it is each using once daily morning and evening, adhere to using 1 month.Specific effect is as shown in table 1,
Table 1 is improvement of the eyeware products and solution for lenses and contact lenses provided in an embodiment of the present invention to black eye and fat granule.
Improvement of the eyeware products and solution for lenses and contact lenses provided in an embodiment of the present invention of table 1 to black eye and fat granule
As shown in Table 1, embodiment 6 is compared, the eyeware products and solution for lenses and contact lenses that Examples 1 to 5 provides has black eye and fat granule
There is the improvement become apparent, this explanation is better than common product using the improvement of nanogel product.Embodiment 6
Effect is better than comparative example 1~3, and the content of the active constituent in comparative example 1~3 is identical as the content of active constituent in embodiment 6,
But its effect is poor, illustrates that Gotu Kola P.E, purple ball algae extract, corn poppy's extract have synergistic effect.
Embodiment 10
Moisture-keeping efficacy test:
Choose health volunteer, the age at 25-50 years old, test site room temperature (25 ± 1) DEG C, relative humidity (40 ±
5) %, it is desirable that tester shifts to an earlier date 30min and enters test environment.On the inside of tester's left and right arm mark tested person region (3cm ×
3cm), same arm can mark multiple regions (interval 1cm) simultaneously, and test sample is randomly dispersed in left and right arm.First survey
The blank value of each test zone is tried, then test specimens press (2.0 ± 0.1) mg/cm2Dosage carry out single smearing, adopt after smearing
With Multi-functional skin moisture tester and moisture of skin scatter and disappear instrument measure 1 respectively, 2, the tested region 4h and blank control region
Skin moisture content and through transepidermal water windage (TEWL), according to being measured in parallel 5 times, blank control region is in each region
Any sample is not smeared.The eyeware products and solution for lenses and contact lenses according to above scheme prepared by the embodiment of the present invention 1~6 and comparative example 1~3 into
The test of row moisture-keeping efficacy, as a result as shown in table 2 and table 3, table 2 is the skin moisture content (%) of different time (h), and table 3 is not
Same time (h) through transepidermal water windage (%).
The skin moisture content (%) of 2 different time (h) of table
3 different time (h) of table through transepidermal water windage (%)
| Test specimens | 0 | 1 | 2 | 4 |
| Blank control group | 15.59 | 15.83 | 15.16 | 15.79 |
| Embodiment 1 | 15.70 | 13.16 | 11.95 | 12.18 |
| Embodiment 2 | 15.47 | 12.73 | 11.58 | 11.24 |
| Embodiment 3 | 15.65 | 12.07 | 11.49 | 10.58 |
| Embodiment 4 | 15.50 | 12.34 | 11.62 | 10.91 |
| Embodiment 5 | 15.49 | 12.95 | 11.73 | 11.57 |
| Embodiment 6 | 15.62 | 13.90 | 13.51 | 12.83 |
| Comparative example 1 | 15.41 | 13.64 | 13.07 | 12.59 |
| Comparative example 2 | 15.53 | 13.72 | 13.25 | 12.67 |
| Comparative example 3 | 15.68 | 13.62 | 12.93 | 12.55 |
By table 2 and table 3 it is found that compared with embodiment 6 and comparative example 1~3, the guarantor of the eyeware products and solution for lenses and contact lenses of Examples 1 to 5
Wet better effect can significantly improve skin water content, make the lasting water lock of skin, have good moisture-keeping efficacy.
Embodiment 11
Skin elasticity test
180 women are chosen, the age between 25-50 years old, is randomly divided into 9 groups, after cleaning is facial, takes the sheet of grain of rice size
Eyeware products and solution for lenses and contact lenses prepared by inventive embodiments 1~6 and comparative example 1~3 is applied to eye surrounding, and flicking absorbs, daily
Sooner or later respectively using primary, using skin elasticity tester, test respectively the 1st, 2,4 week tested region skin elasticity index R2,
R5, R7 (it is 450mbar that negative pressure is constant in test process), take user's test result average value.After tested region clean
The skin elasticity index of 30min is initial value.Index explanation: skin elasticity index R2, R5, R7 illustrates the bullet of skin closer to 1
Property is better.Shown in 4~table of test result table 12.
The product skin elasticity index of 4 embodiment 1 of table preparation
| Test period | R2 | R5 | R7 |
| 0 | 0.5022 | 0.4713 | 0.4205 |
| 1 | 0.6673 | 0.6381 | 0.5603 |
| 2 | 0.7863 | 0.7605 | 0.6954 |
| 4 | 0.9057 | 0.8830 | 0.8463 |
The product skin elasticity index of 5 embodiment 2 of table preparation
| Test period | R2 | R5 | R7 |
| 0 | 0.4822 | 0.4613 | 0.4483 |
| 1 | 0.6242 | 0.6301 | 0.5822 |
| 2 | 0.7654 | 0.7505 | 0.7209 |
| 4 | 0.9114 | 0.8830 | 0.8753 |
The product skin elasticity index of 6 embodiment 3 of table preparation
| Test period | R2 | R5 | R7 |
| 0 | 0.4507 | 0.4791 | 0.4172 |
| 1 | 0.6181 | 0.6273 | 0.5607 |
| 2 | 0.7529 | 0.7732 | 0.7047 |
| 4 | 0.9045 | 0.9137 | 0.8507 |
The product skin elasticity index of 7 embodiment 4 of table preparation
| Test period | R2 | R5 | R7 |
| 0 | 0.5017 | 0.4802 | 0.4397 |
| 1 | 0.6704 | 0.6410 | 0.6034 |
| 2 | 0.8292 | 0.8024 | 0.7503 |
| 4 | 0.9477 | 0.9236 | 0.8852 |
The product skin elasticity index of 8 embodiment 5 of table preparation
| Test period | R2 | R5 | R7 |
| 0 | 0.4792 | 0.4835 | 0.4029 |
| 1 | 0.6307 | 0.6438 | 0.5527 |
| 2 | 0.7731 | 0.7920 | 0.7014 |
| 4 | 0.9053 | 0.9127 | 0.8552 |
The product skin elasticity index of 9 embodiment 6 of table preparation
| Test period | R2 | R5 | R7 |
| 0 | 0.4953 | 0.4811 | 0.4027 |
| 1 | 0.6215 | 0.6394 | 0.5315 |
| 2 | 0.7103 | 0.7517 | 0.6339 |
| 4 | 0.8205 | 0.8351 | 0.7535 |
The product skin elasticity index of 10 comparative example 1 of table preparation
| Test period | R2 | R5 | R7 |
| 0 | 0.4815 | 0.4796 | 0.4258 |
| 1 | 0.5733 | 0.5804 | 0.5071 |
| 2 | 0.6529 | 0.6925 | 0.5932 |
| 4 | 0.7483 | 0.7741 | 0.7049 |
The product skin elasticity index of 11 comparative example 2 of table preparation
| Test period | R2 | R5 | R7 |
| 0 | 0.4619 | 0.4750 | 0.4227 |
| 1 | 0.5481 | 0.5692 | 0.4961 |
| 2 | 0.6167 | 0.6409 | 0.5719 |
| 4 | 0.6835 | 0.7214 | 0.6472 |
The product skin elasticity index of 12 comparative example 3 of table preparation
Known by table 4~12, compared with embodiment 6 and comparative example 1~3, uses the eye-care of Examples 1 to 5 preparation
After product 4 weeks, the skin elasticity index promotion of recipient site is more significant, and closer 1, the effect that wherein embodiment 6 is presented
It is better than comparative example 1~3 again.This says that the effect of nanogel eyeware products and solution for lenses and contact lenses prepared by the present invention is substantially better than common product,
And 3 kinds of Gotu Kola P.E, purple ball algae extract, corn poppy's extract extracts have synergistic effect, product effect is better than single
It solely include a kind of product of extract.Therefore, eyeware products and solution for lenses and contact lenses of the invention can effectively solve the eye skin of wrinkle, eye pouch
Problem.
As seen from the above embodiment, the present invention provides a kind of eyeware products and solution for lenses and contact lenses, including Gotu Kola P.E, purple ball algae
Extract, corn poppy's extract, moisturizer, oil, surfactant, cosurfactant, gel-type vehicle, pH adjusting agent, wetting
Agent and water.Compared with prior art, effect ingredient in eyeware products and solution for lenses and contact lenses provided by the invention is Gotu Kola P.E, purple ball
Algae extract and corn poppy's extract, in the association of three kinds of Gotu Kola P.E, purple ball algae extract and corn poppy's extract ingredients
Under same-action, make eyeware products and solution for lenses and contact lenses provided by the invention that can dramatically increase the elasticity of skin, effectively solution black eye, eye pouch,
The eye skins problem such as wrinkle, and also have the function of improving fat granule and edema；Cooperate in eyeware products and solution for lenses and contact lenses simultaneously
Other compositions make eyeware products and solution for lenses and contact lenses provided by the invention have preferable moistening effect, can be improved eye part skin moisture.
Mentioned component is preferably prepared into nano-emulsion gel products by the present invention, compared with Common hydrogels, nano-emulsion gel
Have with skin and preferably couple and hydration effect, good biocompatibility, can long period and site of action tight adhesion, dispersion is
It is even, be conducive to fully absorbing for active constituent, to improve its bioavilability.
Claims (4)
1. a kind of eyeware products and solution for lenses and contact lenses, including Gotu Kola P.E, purple ball algae extract, corn poppy's extract, moisturizer, oil,
Surfactant, cosurfactant, gel-type vehicle, pH adjusting agent, wetting agent and water；
The eyeware products and solution for lenses and contact lenses is nano-emulsion gel；
Mass content of the Gotu Kola P.E in eyeware products and solution for lenses and contact lenses is 1~6%；
Mass content of the purple ball algae extract in eyeware products and solution for lenses and contact lenses is 1~5%；
Mass content of the corn poppy's extract in eyeware products and solution for lenses and contact lenses is 0.5~1.5%；
Corn poppy's extract spends seed from corn poppy；
Mass content of the moisturizer in eyeware products and solution for lenses and contact lenses is 2~7%；
Mass content of the oil in eyeware products and solution for lenses and contact lenses is 1~4.5%；
The surfactant is selected from one or more of Tween-80, Tween-40, Emulsifier EL-60 and soybean lecithin；
Mass content of the surfactant in eyeware products and solution for lenses and contact lenses is 10~25%；
The cosurfactant is selected from polyethylene glycol or propylene glycol；
Mass content of the cosurfactant in eyeware products and solution for lenses and contact lenses is 5~10%；
The gel-type vehicle is selected from carbomer, xanthan gum, seaweed glue, chitosan, Arabic gum or tara gum；
Mass content of the gel-type vehicle in eyeware products and solution for lenses and contact lenses is 0.1~0.6%；
The pH value for the eyeware products and solution for lenses and contact lenses that the dosage of the pH adjusting agent makes is 5~7；
Mass content of the wetting agent in eyeware products and solution for lenses and contact lenses is 3~9%.
2. eyeware products and solution for lenses and contact lenses according to claim 1, which is characterized in that the moisturizer be selected from acetyl group tetrapeptide -5,
One of ethoxy urea, ceramide, Sodium Hyaluronate, levulan, allantoin, reed fragrant plant oil, D-sorbite and glycine betaine or
It is several.
3. eyeware products and solution for lenses and contact lenses according to claim 1, which is characterized in that the oil is selected from olive oil, ethyl oleate, pungent
One or more of acid/Triglyceride DDD, isopropyl myristate, jojoba oil and vitamin E.
4. eyeware products and solution for lenses and contact lenses according to claim 1, which is characterized in that the pH adjusting agent be selected from triethanolamine and/
Or citric acid.
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| CN107583033B (en) * | 2017-09-05 | 2018-07-10 | 江西宜信堂医疗科技有限公司 | A kind of eye-care compositions and the phototherapy safety goggles containing the composition |
| CN107875079B (en) * | 2017-10-18 | 2021-01-05 | 马应龙大健康有限公司 | Fat-particle-removing essence and preparation method thereof |
| CN109394647B (en) * | 2018-12-17 | 2021-10-15 | 海南诗博丽生物科技有限公司 | Dendrobium restoration eye cream and preparation method thereof |
| CN111939113A (en) * | 2019-05-16 | 2020-11-17 | 广州玉鑫商业运营管理有限公司 | Multi-effect eye muscle activating base solution and preparation method thereof |
| CN111658557A (en) * | 2020-06-22 | 2020-09-15 | 泉后(广州)生物科技研究院有限公司 | Nano-structure liposome capable of eliminating eye bags immediately and preparation method and application thereof |
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