CN109620777A - One kind going fat granule composition and its application - Google Patents
One kind going fat granule composition and its application Download PDFInfo
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- CN109620777A CN109620777A CN201910112843.3A CN201910112843A CN109620777A CN 109620777 A CN109620777 A CN 109620777A CN 201910112843 A CN201910112843 A CN 201910112843A CN 109620777 A CN109620777 A CN 109620777A
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- fat granule
- granule composition
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/82—Preparation or application process involves sonication or ultrasonication
Abstract
The invention belongs to daily cosmetics technical fields, and in particular to one kind goes fat granule composition and its application.One kind provided by the invention removes fat granule composition, including 10-18 parts of cumquat essential oil, and 3-8 parts of Bergamot, 5-8 parts of lemon, 0.5-2 parts and Radix Gentianae extract 4-8 parts of Tretinoin.It is provided by the invention that remove fat granule composition be the mixture for forming homemade cumquat essential oil and Bergamot, lemon, Radix Gentianae extract and Tretinoin by a certain percentage, it can effectively dissolve and go fat granule removal, and have effects that antibacterial, moisturizing and promote wound healing.Provided by the invention to remove ingredient used in fat granule composition be natural products, mild non-stimulated, is suitble to eyelid position to use, can be used for preparing eye cream.
Description
Technical field
The invention belongs to daily cosmetics technical fields, and in particular to one kind goes fat granule composition and its application.
Background technique
Fat granule is a kind of white goose pimples of length on the skin, and it is big that there are about syringe needles, it appears that it seem one small white sesameseed,
It mostly occurs around eyes.Fat granule is as produced by endopathic cause and external factor.Formed fat granule the reason of mainly include with
Under several aspects:
1. fat metabolic disturbance: due to body endocrine disorder, cause fat secretion superfluous, skin oil and fat is unevenly distributed,
Eye circumference part grease crosses Sheng, to cause the short grained generation of eye circumference.
2. undesirable makeup habit: excessively using scrub cream or exfoliating product, easily generate small wound on the skin
Mouthful, cause skin to generate the small tumour of white during self-regeneration.
3. inappropriate skin care: for desalination wrinkle, black eye is eliminated, it is blindly smart using wrinkle, black-eyed eye is repaired
China and eye cream become soft by skin, but such eye essence and eye cream all have the excessive phenomenon of nutriment, eye part skin group
Thin, absorption difference is knitted, most of nutriment is deposited in eye circumference blocking pore, forms fat granule.
4. makeup removing is not thorough: drawing dense eye make-up, makeup removing is not thorough, and be easy to cause clogging of pores, induces fat granules around eyes
It generates.
For the generation for reducing fat granule, patent document CN105213203A discloses a kind of system of microcapsule-type moisturizing eye cream
Preparation Method, the moisturizing eye cream that this method provides can uniformly discharge and be easy to absorb, with nourishes effect is good, will not cause fat
Grain generates, active material is not easy the characteristics of being destroyed by external environment.Can solve it is above-mentioned because of fat granule caused by inappropriate skin care,
But the generation of fat granules around eyes caused by being not thorough because of fat metabolism disorder, bad makeup habit and makeup removing can not be eliminated.
Separately there is patent document CN107875079A just to open one kind and go fat granule essence and preparation method thereof, this removes fat granule
The effect of essence material composition include: allantoin, asiaticosid, wolfberry fruit extract, angelica extract, VE, hyaluronic acid, gold thread
Plum, elder, Matrixyl3000 and thickener, moisturizer, stabilizer, skin conditioning agent and preservative；This removes fat granule
Essence can prevent grease grain from growing, and can reach certain therapeutic effect simultaneously, and grease grain is made to reduce or disappear；And the degreasing
Fat grain essence is while going fat granule effect, the characteristics of being also equipped with moist, moisturizing, appearance salubrious, non-greasy.But this removes fat
Grain essence uses rear irritating reaction, slight burning heat sensation occurs, however this special onset position of eyelid constrains making for it
With.It is chosen using needle or the method for laser therapy goes fat granule removal in addition, having, but this method can be with wound infection, recurrent exerbation
Symptom, and laser goes fat granule expensive, limited using crowd, and thus still lacking at present a can prevent and go
Fat granule removal occurs, and can take good care of skin, delays senescence, does not block pore, and the eye cream one mildly easily absorbed solves consumer and looks back
Sorrow.
Summary of the invention
The present invention is intended to provide a kind of composition that can effectively remove and prevent fat granule, and the composition is mildly easily inhaled
It receives, eyelid cell can be repaired, delay eyelid skin aging, do not block pore.
In order to achieve the above object, the invention adopts the following technical scheme:
One kind going fat granule composition, including following component and its parts by weight:
10-18 parts of cumquat essential oil, 3-8 parts of Bergamot, 5-8 parts of lemon, 0.5-2 parts of Tretinoin and rough gentian extract
4-8 parts of object.
It is further, described that remove fat granule composition include following component and its parts by weight:
12-15 parts of cumquat essential oil, 4-5 parts of Bergamot, 5-6 parts of lemon, 0.5-1 parts of Tretinoin and rough gentian extract
4-6 parts of object.
Further, the Radix Gentianae extract obtain the preparation method comprises the following steps:
The ethanol water refluxing extraction 1-2h for being 80% by gentian volume fraction, the gentian and volume fraction
Solid-to-liquid ratio for 80% ethanol water is 1g:(85-90) mL, reflux extracting liquid is taken, is concentrated under reduced pressure, is dried, is crushed, mistake
120 meshes to get.
Further, the cumquat essential oil the preparation method is as follows:
A: the cumquat of fresh picking is cleaned up, and is air-dried, is taken cumquat skin, shred, and is added in pretreatment fluid, sealing storage
2-4h must pre-process cumquat skin mixture；
B: being added distilled water into pretreatment cumquat skin mixture obtained in step A, in ultrasonic power 400-500W, temperature
Under the conditions of degree is 25-30 DEG C, after ultrasonic 1-2h, the aqueous hydrochloric acid solution that dropwise addition molar concentration is 2mol/L, adjusting pH value, centrifugation,
Centrifugal speed is 4500rpm-6000rpm, and centrifugation time 15-20min takes supernatant liquid, steam distillation after centrifugation
Extract to get.
Further, in the step A pretreatment fluid by mass ratio be (1.2-1.8): (0.02-0.05): (10-12's)
Sodium chloride, sodium hydroxide and water composition.
Further, the solid-to-liquid ratio of cumquat skin and pretreatment fluid is (3-5) g:10mL in the step A.
Further, the solid-to-liquid ratio that cumquat skin mixture and distilled water are pre-processed in the step B is 1g:(20-25) mL.
Further, the pH value adjusted in the step B is 4-4.5.
The present invention also provides the preparation method for removing fat granule composition, operating procedure is as follows:
Tretinoin and Radix Gentianae extract are mixed, stirred evenly, cumquat essential oil, lemon and Bergamot is added,
Temperature be 40-45 DEG C, revolving speed be 250-400rpm under conditions of stir 10-12min, be uniformly mixed to get.
Another object of the present invention is to provide described to go fat granule composition in preparing eye cream, essence or lotion
Using.
Bergamot is bergamot bark extract, and antibacterial action is obvious, to eczema, chronic eczema, acne, scabies, vein
Varicose, wound, bubble rash, the seborrheic dermatitis of skin and scalp are effective in cure.
Lemon is lemon extract, can improve circulatory function, including promote blood circulation, to reduce blood pressure,
Only nosebleed.Immune system can be enhanced in it, purifies body, improves digestive system function, treats indigestion and constipation.Also help
In cleaning acne, Greasy Skin and hair are cleaned, and remove dead skin cells.In addition, the fragrance that lemon is pure and fresh, can refresh oneself awake
Brain is inspired enthusiasm, and irritated, purification air is alleviated.
Tretinoin is the metabolic intermediate of internal vitamin A, the main growth for influencing bone and promote epithelial hyperplasia,
The metabolism such as differentiation, cutin dissolution.For treating acne vulgaris, psoriasis, ichthyosis, lichen planus, pityriasis rubra pilaris, hair
The diseases such as capsule keratosis, squamous cell carcinoma and melanoma.
Rough gentian is gentianaceae plant, and perennial herb, Radix Gentianae extract is from gentianaceae plant Gentiana manshurica, rough gentian, three
It is extracted in the dry root and stem of flower rough gentian or Gentiana rigescens, main component is gentiamarin and bitter rough gentian rouge glycosides, is had clear
Effect of hot eliminating dampness, purging the liver of pathogenic fire gallbladder fire, be mainly used for treat jaundice with damp-heat pathogen, swelling of vulva pruritus vulvae, leukorrhagia, eczema itch, hot eyes, hypochondriac pain,
The symptoms such as convulsion, the present invention are found surprisingly that Radix Gentianae extract produced by the present invention has bacteriostasis, and the rough gentian
Extract has the effect of antiallergic sense, anti-irritant, solves the problems, such as that Tretinoin has irritation to skin.
Cumquat: alias is kumquat, golden mandarin orange, small cumquat, is evergreen shrubs, is grown under warm, wet environment more, intolerant to
It is cold, slightly shade tolerant, it resists cold.Cumquat essential oil is cumquat bark extract, and the present invention uses specific extracting method, the cumquat extracted
Refined oil rate is high, and cumquat essential oil has special aromatic odor as lemon, can alleviate agitation, pure and fresh to soothe the spirit.Cumquat
Essential oil has strong anti-oxidation, is usually used in fermentation, distillation, wine of the ageing preparation with special aroma and nutritive value, Huo Zhetian
It adds in tealeaves, adjusts the mouthfeel of tealeaves, alleviate the bitter taste of tealeaves, refresh the mind.The gold that the present invention for the first time obtains extraction
Tangerine essential oil is for removing or preventing fat granule, by it with Bergamot, lemon, Radix Gentianae extract and Tretinoin by certain
Ratio is used in mixed way, experiments have shown that, the composition can effectively dissolve and go fat granule removal, still further, it was discovered that its fungistatic effect is good,
Moistening effect is good, has the function of centainly promoting wound healing, also, it is natural products that the composition is raw materials used, mildly
Stablize, it is non-stimulated, the composition is used to prepare eye eye cream, eye essence or eye emulsions, both can remove and prevent
The generation of fat granule, and eye skin can be moistened with replenishing water and preserving moisture, prevent black eye, desalinates eye wrinkle-removing.
Compared with prior art, of the invention that fat granule composition is gone to have the advantage that
(1) it is provided by the invention go fat granule composition be by homemade cumquat essential oil and Bergamot, lemon,
The mixture that Radix Gentianae extract, Tretinoin and water form by a certain percentage can effectively dissolve and go fat granule removal, and have suppression
The effect of bacterium, moisturizing and promotion wound healing.
(2) provided by the invention to remove ingredient used in fat granule composition be natural products, mild non-stimulated, is suitble to eyelid
Position uses, and can be used for preparing with eye cream, eye essence or eye emulsions.
Specific embodiment
The specific embodiment of form by the following examples makees further specifically above content of the invention
It is bright.But the range that this should not be interpreted as to the above-mentioned theme of the present invention is only limitted to following embodiment.Lemon provided by the invention
Jiangxi Po Lam natural perfume material Co., Ltd is purchased from Bergamot.
The preparation of embodiment 1, cumquat essential oil
The cumquat essential oil the preparation method comprises the following steps:
A: the cumquat of fresh picking is cleaned up, air-dry, take cumquat skin, shred, be added by sodium chloride, sodium hydroxide and
In the pretreatment fluid of water 1.2:0.02:10 in mass ratio composition, the solid-to-liquid ratio of cumquat skin and pretreatment fluid is 3g:10mL, sealing
2.5h is stored, cumquat skin mixture must be pre-processed；
B: distilled water is added to pretreatment cumquat skin mixture obtained in step A, pre-processes cumquat skin mixture and steaming
Distilled water is 1g:20mL mixing by solid-to-liquid ratio, in ultrasonic power 400W, under the conditions of temperature is 30 DEG C, and after ultrasonic 1.5h, dropwise addition mole
Mass concentration is the hydrochloric acid of 2mol/L, and adjusting pH value is 4.5, and centrifugation, revolving speed 4500rpm, time 15min take after centrifugation
Supernatant liquid, extraction by steam distillation to get.
The preparation of embodiment 2, Radix Gentianae extract
The Radix Gentianae extract the preparation method is as follows:
The ethanol water refluxing extraction 1.5h for being 80% by gentian volume fraction, the gentian and t volume point
Number is 1g:87mL for the solid-to-liquid ratio of 80% ethanol water, takes reflux extracting liquid, is concentrated under reduced pressure, and powder is beaten in drying, crosses 120 mesh
Sieve to get.
Embodiment 3, one kind remove fat granule composition
It is described that fat granule composition is gone to be made of following component and its parts by weight:
10 parts of cumquat essential oil, 3 parts of Bergamot, 5 parts of lemon, 0.5 part and 4 parts of Radix Gentianae extract of Tretinoin；It is described
Cumquat essential oil is made by embodiment 1, and the Radix Gentianae extract is made by embodiment 2.
It is described go fat granule composition the preparation method comprises the following steps:
Tretinoin and Radix Gentianae extract are mixed, stirred evenly, cumquat essential oil, lemon and Bergamot, temperature is added
Degree be 40 DEG C, revolving speed 250rpm, stir 10min, be uniformly mixed to get.
Embodiment 4, one kind remove fat granule composition
It is described that fat granule composition is gone to be made of following component and its parts by weight:
18 parts of cumquat essential oil, 8 parts of Bergamot, 8 parts of lemon, 2 parts of Tretinoin and 8 parts of Radix Gentianae extract；The gold
Tangerine essential oil is made by embodiment 1, and the Radix Gentianae extract is made by embodiment 2.
The preparation method for removing fat granule composition is similar to Example 3.
Embodiment 5, one kind remove fat granule composition
It is described that fat granule composition is gone to be made of following component and its parts by weight:
14 parts of cumquat essential oil, 5 parts of Bergamot, 6 parts of lemon, 1 part of Tretinoin and 6 parts of Radix Gentianae extract；The gold
Tangerine essential oil is made by embodiment 1, and the Radix Gentianae extract is made by embodiment 2.
The preparation method for removing fat granule composition is similar to Example 3.
Comparative example 1, one kind remove fat granule composition
It is described that fat granule composition is gone to be made of following component and its parts by weight:
5 parts of Bergamot, 6 parts of lemon, 1 part of Tretinoin and 6 parts of Radix Gentianae extract；The cumquat essential oil is by implementing
Example 1 is made, and the Radix Gentianae extract is made by embodiment 2.
The preparation method for removing fat granule composition is similar to Example 3.
Difference with embodiment 4 is not add cumquat essential oil.
Comparative example 2, one kind remove fat granule composition
It is described that fat granule composition is gone to be made of following component and its parts by weight:
14 parts of cumquat essential oil, 6 parts of lemon, 1 part of Tretinoin and 6 parts of Radix Gentianae extract；The cumquat essential oil is by embodiment
1 is made, and the Radix Gentianae extract is made by embodiment 2.
The preparation method for removing fat granule composition is similar to Example 3.
Difference with embodiment 4 is not add Bergamot.
Comparative example 3, one kind remove fat granule composition
It is described that fat granule composition is gone to be made of following component and its parts by weight:
14 parts of cumquat essential oil, 5 parts of Bergamot, 1 part of Tretinoin and 6 parts of Radix Gentianae extract；The cumquat essential oil is by implementing
Example 1 is made, and the Radix Gentianae extract is made by embodiment 2.
The preparation method for removing fat granule composition is similar to Example 3.
Difference with embodiment 4 is not add lemon.
Comparative example 4, one kind remove fat granule composition
It is described that fat granule composition is gone to be made of following component and its parts by weight:
14 parts of cumquat essential oil, 5 parts of Bergamot, 6 parts of lemon, 1 part of Tretinoin and 6 parts of perilla herb oil；The cumquat essence
Oil is made by embodiment 1, and the Radix Gentianae extract is made by embodiment 2.
The preparation method for removing fat granule composition is similar to Example 3.
Difference with embodiment 4 is to replace Radix Gentianae extract with perilla herb oil, and the perilla herb oil is purchased from long Bai Gongfang.
Test example one, the effect test for removing fat granule composition
1, experimental subjects: will go fat granule composition to be added in eye cream made from embodiment 3-5 and comparative example 1-3, mixing
Uniformly, preparation is commercially available removes fat granule eye cream.
2, experimental method:
2.1 go fat granule effect
Participate in object: 14 female volunteers of the eye with fat granule, age at 20-35 years old, are divided into 7 groups, every group 2
People.
It is early daily be later than face cleaning and skin toner after use, take 1mL embodiment 3-5 and it is commercially available remove fat granule eye cream, be applied to eye circumference,
The homogeneously kneaded in such a way that the third finger loops lift up and down, is repeated several times to absorption, is used continuously 1 month, fixation is recorded in
Eye circumference 1*2cm2Locate the quantity of fat granule.
3, test result:
Experimental result such as table 1.
Table 1 removes fat granule effect test
As shown in Table 1, the effect of fat granule composition is gone obviously to remove fat granule than commercially available made from 3-5 of the embodiment of the present invention
The effect of fat granule composition is gone made from eye cream and comparative example 1-3, especially 5 fat granule removal rate of the embodiment of the present invention is up to
47.4%, higher than the removal rate of commercially available eye cream by 25.2%, therefore, embodiment 5 is highly preferred embodiment of the present invention.And comparative example 1-
In 3, due to eliminating certain component, fat granule removal rate is caused to significantly reduce, especially comparative example 1 eliminates cumquat essential oil
Afterwards, fat granule removal rate is only 11.8%, it is seen then that cumquat essential oil is most important to the removal of fat granule.
Test example two, acute ocular irritation test
1, experimental subjects: fat granule composition is removed made from the embodiment of the present invention 5 and comparative example 1-4.
2, experimental method:
Animal: regular grade rabbit 30, male is divided into 5 groups, every group 6.According to " cosmetics safety technical specification "
(version in 2015) carries out acute ocular irritation test.
It is interior for 24 hours before test that (including fluorescein sodium inspection) is checked to two eyes of test.
In the conjunctival sac for the left eye for taking the 1mL present invention that fat granule composition is gone to be painted into animal, with the other side not dealt with
Eyes are as own control.According to specification 1 after being painted into the present invention and removing fat granule composition, 24,48h using handheld slit lamp into
Row scoring, and checked when for 24 hours using fluorescein sodium.48h does not have found stimulate the reaction, and terminates on probation.
It scores by specification, check plot and trial zone are equally handled.And calculating average integral is carried out according to formula, by " makeup
Product technical specification of security " carry out stimulus intensity classification.
3, experimental result:
Test result such as table 2.
Table 2 goes fat granule composition to Rabbits with Acute eye irritation result
As shown in Table 2, go fat granule composition to Rabbits with Acute eye made from the embodiment of the present invention 5 and comparative example 1-3
Iris, conjunctiva and cornea will not generate stimulation.And comparative example 4 is smeared since Radix Gentianae extract is replaced with perilla herb oil
After for 24 hours, very big irritation is generated to eye and is just disappeared to the stimulation of eye, it is seen then that Radix Gentianae extract is to acute after 48h
The stimulation of eye has preferable remission effect.
Test example three promotes wound healing assay
1, experimental subjects: fat granule composition is removed made from embodiment 5 and comparative example 1-4.
2, experimental method:
SD male rat 60, every 220 ± 20g of weight are taken, random point 6 groups, every group 10, difference label, in back ridge
Column side, cuts off hair, scratches long 2 ± 0.2cm with scalpel, the edge of a knife of 0.2 ± 0.1cm of depth, smears embodiment 3 and right respectively
Remove fat granule composition 0.5mL made from ratio 1-4, blank control group smears physiological saline, smear in the morning, afternoon and evening daily three times,
1st day, the 3rd day, the 7th day and the 15th day observation wound healing situation evaluates wound healing situation with Wound healing rate.3, it tests
As a result: Wound healing rate situation is shown in Table 3.
3 Wound healing rate comparing result (%) of table
As shown in Table 3, after 15 days, the Wound healing rate of the embodiment of the present invention 5 can achieve 98.48%, and comparative example 1-4
Wound healing rate 80% or so, the Wound healing rate of especially comparative example 4 is only 70.38%, the healing with blank control
Rate is similar, therefore, can further illustrate Radix Gentianae extract to the facilitation of healing effect, moreover, each group in the present invention
It is point mutually coordinated, there is good facilitation to healing effect.
The above-described embodiments merely illustrate the principles and effects of the present invention, and is not intended to limit the present invention.It is any ripe
The personage for knowing this technology all without departing from the spirit and scope of the present invention, carries out modifications and changes to above-described embodiment.Cause
This, institute is complete without departing from the spirit and technical ideas disclosed in the present invention by those of ordinary skill in the art such as
At all equivalent modifications or change, should be covered by the claims of the present invention.
Claims (10)
1. one kind removes fat granule composition, which is characterized in that including following component and its parts by weight:
10-18 parts of cumquat essential oil, 3-8 parts of Bergamot, 5-8 parts of lemon, 0.5-2 parts of Tretinoin and Radix Gentianae extract 4-8
Part.
2. according to claim 1 remove fat granule composition, which is characterized in that including following component and its parts by weight:
12-15 parts of cumquat essential oil, 4-5 parts of Bergamot, 5-6 parts of lemon, 0.5-1 parts of Tretinoin and Radix Gentianae extract 4-6
Part.
3. according to claim 1 or 2 remove fat granule composition, which is characterized in that the preparation side of the Radix Gentianae extract
Method are as follows:
The ethanol water refluxing extraction 1-2h for being 80% by gentian volume fraction, the gentian and ethanol water
Solid-to-liquid ratio is 1g:(85-90) mL, take reflux extracting liquid, be concentrated under reduced pressure, dry, crush, cross 120 meshes to get.
4. according to claim 1 or 2 remove fat granule composition, which is characterized in that the preparation method of the cumquat essential oil
It is as follows:
A: the cumquat of fresh picking is cleaned up, and is air-dried, is taken cumquat skin, shred, and is added in pretreatment fluid, sealing storage 2-
4h must pre-process cumquat skin mixture；
B: distilled water is added into the pretreatment cumquat skin mixture that step A is obtained, in ultrasonic power 400-500W, temperature is
Under the conditions of 25-30 DEG C, after ultrasonic 1-2h, the hydrochloric acid that molar concentration is 2mol/L is added dropwise, adjusts pH value, centrifugation, centrifugal speed is
4500rpm-6000rpm, centrifugation time 15-20min, take supernatant liquid after centrifugation, extraction by steam distillation to get.
5. according to claim 4 remove fat granule composition, which is characterized in that pretreatment fluid is by quality in the step A
Than for (1.2-1.8): (0.02-0.05): sodium chloride, sodium hydroxide and the water of (10-12) form.
6. according to claim 4 remove fat granule composition, which is characterized in that cumquat skin and pretreatment in the step A
The solid-to-liquid ratio of liquid is (3-5) g:10mL.
7. according to claim 4 remove fat granule composition, which is characterized in that it is mixed to pre-process cumquat skin in the step B
The solid-to-liquid ratio for closing object and distilled water is 1g:(20-25) mL.
8. according to claim 4 remove fat granule composition, which is characterized in that adjusting pH value in the step B is 4-
4.5。
9. a kind of such as the described in any item preparation methods for removing fat granule composition of claim 1-8, which is characterized in that preparation step
It is rapid as follows:
Tretinoin and Radix Gentianae extract are mixed, stirred evenly, cumquat essential oil, lemon and Bergamot is added, in temperature
Be 40-45 DEG C, revolving speed be 250-400rpm under conditions of stir 10-12min, be uniformly mixed to get.
10. according to claim 1 remove fat granule composition, the application in eye cream, essence or lotion is being prepared.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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