CN111888457A - Anti-hair loss traditional Chinese medicine composition and preparation method and application thereof - Google Patents
Anti-hair loss traditional Chinese medicine composition and preparation method and application thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/24—Apocynaceae (Dogbane family), e.g. plumeria or periwinkle
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K36/605—Morus (mulberry)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/82—Theaceae (Tea family), e.g. camellia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/02—Preparations for cleaning the hair
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/12—Preparations containing hair conditioners
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D10/00—Compositions of detergents, not provided for by one single preceding group
- C11D10/04—Compositions of detergents, not provided for by one single preceding group based on mixtures of surface-active non-soap compounds and soap
- C11D10/042—Compositions of detergents, not provided for by one single preceding group based on mixtures of surface-active non-soap compounds and soap based on anionic surface-active compounds and soap
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/02—Anionic compounds
- C11D1/12—Sulfonic acids or sulfuric acid esters; Salts thereof
- C11D1/29—Sulfates of polyoxyalkylene ethers
Abstract
The invention provides a traditional Chinese medicine composition for preventing alopecia and a preparation method thereof, wherein the traditional Chinese medicine composition is prepared from the following traditional Chinese medicine raw materials in parts by weight: 1-3 parts of wormwood, 0.5-2 parts of ginger, 1-3 parts of tuber fleeceflower stem, 2-5 parts of tea bran, 1-3 parts of mulberry leaf, 0.5-2 parts of apocynum venetum leaf and 0.5-2 parts of wild rice; and provides the application of the traditional Chinese medicine composition in preparing anti-hair loss, hair growth and daily use chemicals. The traditional Chinese medicine extract is extracted by adopting a proper extraction method, so that infectious alopecia can be effectively improved, and the traditional Chinese medicine extract has a good antibacterial effect and low irritation and is very safe to a human body.
Description
Technical Field
The invention relates to the technical field of preparation of daily chemical products, and particularly relates to a traditional Chinese medicine composition for preventing alopecia, and a preparation method and application thereof.
Background
Alopecia refers to the phenomenon of hair loss. The normal hair loss is the hair in the catagen and telogen phases, and the normal amount of hair can be maintained because the hair entering the catagen phase and the hair newly entering the anagen phase are constantly in dynamic balance. Alopecia is normal metabolism, and in life, everyone suffers from alopecia. While pathologic hair loss refers to abnormal or excessive hair loss. Generally, 50-60 hairs lost in one day of a normal adult are normal phenomena, and the hair loss signals when more than 100 hairs are lost. If more than 100 hairs fall off in one day and the period lasts for more than 2 or 3 months, the patient needs to be hospitalized as soon as possible. Alopecia is a very annoying problem, and according to the latest statistics of the world health organization, one of six Chinese people in the current society has alopecia symptoms. 60% of men begin to lose hair before the age of 25, the proportion of the loss of hair before the age of 30 accounts for 84%, the loss of hair tends to be low-aged, and the middle-aged and young people become the chief force of the hair loss army.
The reasons for alopecia are many, and western medical theory considers that under normal conditions, abundant blood vessels exist in human hair papillae to provide sufficient nutrition for hair papillae and hair bulb parts, so that hair growth hormone is smoothly synthesized. Various adverse stimuli (influence of hormone level, influence of neurostimulation, etc.) cause vasospasm of supplying hair nutrition, and dysfunction of nutrition-transporting function of hair papilla and hair bulb part. When nutrient synthesis is inhibited in the formation of papilla and bulbus pili, or when ATP having a cell energy function is produced due to some factor, production of ATP is inhibited. ATP, which is a heat source, is not produced, and thus protein synthesis of hair is not performed, hair mother cells lose activity, nutrients in medullary and cortex portions of hair are reduced, keratinization begins, hair follicles begin to atrophy or necrose, hair enters a resting stage in a large amount, and hair falls off in a large amount. The prior art is currently studied for androgenetic alopecia, neurogenic alopecia, endocrine alopecia, nutritional alopecia, physical alopecia, chemical alopecia, infectious alopecia, symptomatic alopecia, congenital alopecia, seasonal alopecia, and the like. Alopecia caused by fungal infections, parasites, viruses, and purulent skin diseases is called infectious alopecia. Infectious diseases cause hair loss mainly by infecting microorganisms to directly destroy hair follicles or to form scars to make the hair follicles disappear. Common symptoms of such alopecia include tinea capitis and alopecia folliculitis. The alopecia folliculitis is mostly seen in seborrheic dermatitis of head, is caused by infection of staphylococcus aureus, tinea capitis caused by fungal infection, and the most effective method is to discover the cause at an early stage and treat the disease in a targeted manner.
According to the theory of traditional Chinese medicine, hair has close relation with liver and kidney, kidney stores essence and liver and controls blood, the essence and blood are mainly bloomed in hair, the deficiency of liver and kidney causes insufficiency of essence and blood, and hair follicles can not obtain sufficient nutrition. Otherwise, the liver and kidney are strong and the upper part is good at the head, so the hair is thick and dark.
Due to the huge market potential, a plurality of hair loss prevention, hair growth promotion and hair health care washing products are sold on the market, but the effect is little.
Disclosure of Invention
In order to overcome the defects of the prior art, the invention provides a traditional Chinese medicine composition for preventing alopecia, a preparation method and application thereof, which can improve and treat infectious alopecia in a targeted manner and have a certain hair growth promoting effect, and specifically adopts the following technical scheme:
the invention provides a traditional Chinese medicine composition which is prepared from the following traditional Chinese medicine raw materials in parts by weight: 1-3 parts of wormwood, 0.5-2 parts of ginger, 1-3 parts of tuber fleeceflower stem, 2-5 parts of tea bran, 1-3 parts of mulberry leaf, 0.5-2 parts of apocynum venetum leaf and 0.5-2 parts of wild rice;
further, the traditional Chinese medicine composition is prepared from the following traditional Chinese medicine raw materials in parts by weight: 2 parts of wormwood, 1 part of ginger, 2 parts of tuber fleeceflower stem, 3 parts of tea bran, 2 parts of mulberry leaf, 1 part of apocynum venetum leaf and 1 part of wild rice;
further, the preparation method of the traditional Chinese medicine composition comprises the following steps: weighing the traditional Chinese medicine components according to the proportion, crushing the traditional Chinese medicine components to 120-300 meshes, mixing the other medicines except the wild rice, adding water with the mass being 3-10 times of that of the wild rice, adding water at 70-90 ℃, carrying out reflux extraction twice for 2-4 h each time, collecting an extracting solution, concentrating the extracting solution at 40-60 ℃ under reduced pressure to obtain an extract with the density of 1.2-1.6 g/mL, and mixing the extract with the crushed wild rice to obtain the anti-hair loss traditional Chinese medicine extract; preferably, pulverizing to 200 meshes; preferably, 5 times of water is added by mass; the reflux temperature is 80 ℃; the extraction time is 3 h; the reduced pressure concentration temperature is 50 ℃;
the second aspect of the invention provides an application of the traditional Chinese medicine composition in preparing a daily chemical product for preventing hair loss and growing hair, wherein the daily chemical product is selected from one or more of shampoo, hair conditioner and soap;
further, the preparation method of the shampoo comprises the following steps:
s1 the shampoo is prepared from the following components in percentage by mass: 4-12% of a traditional Chinese medicine composition, 10-15% of fatty alcohol ether sodium sulfate (AES), 0.5-2.0% of a pearly-lustre sheet, 0.1-0.5% of cationic guar gum, 1.0-4.0% of Coconut Monoethanolamide (CMEA), 0.1-1.0% of essence, a proper amount of sodium chloride, a proper amount of citric acid and the balance of water, wherein the viscosity of the shampoo is greater than 0.4Pa.s at 25 ℃, and the pH value of the shampoo is 6-8; preferably, the shampoo is prepared from the following components in percentage by mass: 8% of a traditional Chinese medicine composition, 12% of fatty alcohol ether sodium sulfate (namely AES), 1.0% of a pearly-lustre sheet, 0.3% of cationic guar gum, 2.0% of coconut monoethanolamide (namely CMEA), 0.5% of essence, a proper amount of sodium chloride, a proper amount of citric acid and the balance of water, wherein the viscosity of the shampoo is greater than 0.4Pa.s at 25 ℃, and the pH value of the shampoo is 6.8;
the preparation method of S2 comprises the following steps: weighing the corresponding raw materials according to the mass percentage, starting a stirring pot, adding deionized water, continuously adding cationic guar gum, stirring and heating to 40-50 ℃; adding AES for homogenizing for 8-15 minutes, stopping homogenizing, and continuing stirring for 15-30 minutes until the AES is completely dissolved; continuously heating until the temperature rises to 65-78 ℃, adding the pearlescent sheet and CMEA, heating to above 80 ℃, stopping steam, keeping the temperature, stirring for 30-40 minutes, and then cooling; when the temperature is reduced to 50-70 ℃, adding sodium chloride and citric acid, and adding the traditional Chinese medicine composition and essence at 40-50 ℃; stopping stirring when the temperature of the materials in the pot is reduced to below 40 ℃, then sampling to measure intermediate control indexes, discharging and packaging after meeting the quality intermediate control requirements, and thus obtaining the product; preferably, the temperature is raised to about 45 ℃; preferably, AES is homogenized for 10 minutes; preferably, stirring is continued for 20 minutes until the AES dissolution is complete; preferably; heating to 75 ℃, and adding a pearly-lustre sheet and CMEA; preferably, stirring for 35min under heat preservation; preferably, the temperature for adding the sodium chloride and the citric acid is 60 ℃; preferably, the temperature for adding the Chinese medicinal composition and essence is 45 deg.C.
Further, the preparation method of the hair conditioner comprises the following steps:
s1 the hair conditioner is prepared from the following components in percentage by mass: 3.0-9.0% of a traditional Chinese medicine composition, 2.0-4.0% of monoglyceride, 1.0-3.0% of stearic acid, 1.0-4.0% of 16-18 alcohol, 0.5-2.0% of emulsified silicone oil, 2.0-5.0% of hexadecyl trimethyl ammonium chloride (namely cationic surfactant 1631), 800.1-1.0% of tween-800.0%, 3.0-7.0% of glycerol, 0.1-0.3% of a preservative, 0.1-0.5% of essence and the balance of water, wherein the pH value of the hair conditioner is 6.0-8.0 at 25 ℃; preferably, the hair conditioner is prepared from the following components in percentage by mass: 6.0% of traditional Chinese medicine composition, 3.0% of monoglyceride, 2.0% of stearic acid, 2.0% of 16-18 alcohol, 1.0% of emulsified silicone oil, 2.5% of hexadecyl trimethyl ammonium chloride (namely cationic surfactant 1631), tween-800.5%, 5.0% of glycerol, 0.2% of preservative, 0.3% of essence and the balance of water, wherein the pH value of the hair conditioner is 6.8 at 25 ℃;
the preparation method of S2 comprises the following steps: weighing the corresponding raw materials according to the mass percentage, adding deionized water, hexadecyl trimethyl ammonium chloride and glycerol, heating to 65-80 ℃, then continuously adding monoglyceride, stearic acid, 16-18 alcohol, emulsified silicone oil and tween-80, stirring and homogenizing for 8-15 min, then heating the reaction system to 80-90 ℃, stopping heating and continuously homogenizing for 8-15 min, keeping the temperature, stirring for 5-15 min, cooling, adding the traditional Chinese medicine composition, the preservative and the essence when the temperature of the reaction system is reduced to 40-50 ℃, continuously cooling, stopping stirring when the temperature of materials in a pot is reduced to below 40 ℃, sampling, sending the materials to a mass intermediate control room for measuring intermediate control indexes, discharging and packaging after meeting the requirements of the intermediate control, thus obtaining the product; preferably, adding deionized water, hexadecyl trimethyl ammonium chloride and glycerol, and heating to 70 ℃; preferably, the homogenization is carried out for 10 min; preferably, the reaction system is heated to 85 ℃; preferably, the temperature is reduced after the heat preservation and the stirring are carried out for 10 min; preferably, the traditional Chinese medicine composition, the preservative and the essence are added when the temperature of the reaction system is reduced to 45 ℃.
Advantageous effects
1. The invention adopts the traditional Chinese medicine composition, and the natural traditional Chinese medicine composition is obtained by extraction and has the effects of preventing and improving infectious alopecia. The invention adopts the following Chinese medicinal formula: the wormwood is used as a medicine, has the effects of warming channels, removing dampness, dispelling cold, stopping bleeding, diminishing inflammation, relieving asthma, relieving cough, preventing miscarriage, resisting allergy and the like, and is discovered to have the antibacterial and antifungal effects through modern pharmacological research; the ginger enters lung, spleen and stomach meridians, and has the following main functions: the modern pharmacological research shows that the ginger has the effects of clearing away heat and toxic materials, sterilizing and growing hair; caulis Polygoni Multiflori, entering heart and liver meridians, nourishing heart, tranquilizing mind, dredging collaterals, dispelling pathogenic wind; the tea bran has the effects of absorbing dampness and killing insects, is used for treating scrotum eczema and traumatic injury, and is suitable for consumptive disease, dreaminess, spermatorrhea, weakness after illness, soreness and pain of waist and knees, early graying of hair and chronic malarial; mulberry leaf, folium Mori, enters lung and liver meridians. Has the functions of dispelling wind and heat, clearing lung-heat, moistening dryness, clearing liver and improving eyesight, wherein 7 mulberry leaves are used for washing every day in Wailao Shu, and eyebrow loss is treated, and the record of treating hair deficiency by mulberry leaves in Qianjin Yao Fang is also used in Beiji; the dogbane leaf enters liver meridian, and has the main functions: calming the liver, soothing the nerves, clearing heat and promoting diuresis; the black rice enters the stomach and large intestine and has the functions of mainly relieving restlessness and quenching thirst; regulating stomach and regulating intestine, and the wild rice recorded in ancient prescription has the functions of growing and blackening hair. The medicines have the efficacy of tonifying liver and kidney, and can effectively resist bacteria, balance sebum secretion of the head and stimulate hair follicle growth by adopting a proper extraction method, so that infectious alopecia can be effectively improved.
2. The products such as shampoo and the like prepared by the invention all adopt raw materials which meet the latest requirements of the safety technical specification of cosmetics, do not irritate skin and do not cause harm to human bodies.
Detailed Description
Description of the drawings: the materials and reagents used in the examples and experimental examples of the present invention are commercially available.
Example 1:
a traditional Chinese medicine composition is prepared from the following traditional Chinese medicine raw materials in parts by weight: 1 part of wormwood, 0.5 part of ginger, 1 part of tuber fleeceflower stem, 2 parts of tea bran, 1 part of mulberry leaf, 0.5 part of apocynum venetum leaf and 0.5 part of wild rice; the preparation method of the traditional Chinese medicine composition comprises the following steps: weighing the traditional Chinese medicine components according to the proportion, crushing the traditional Chinese medicine components into 300 meshes, mixing the other medicines except the wild rice, adding water with the mass of 5 times of the traditional Chinese medicine components, adding water at 80 ℃, carrying out reflux extraction twice for 3 hours each time, collecting an extracting solution, concentrating the extracting solution at 50 ℃ under reduced pressure to obtain an extract with the density of 1.2-1.6 g/mL, and then mixing the extract with the crushed wild rice to obtain the anti-hair loss traditional Chinese medicine extract.
Example 2:
a traditional Chinese medicine composition is prepared from the following traditional Chinese medicine raw materials in parts by weight: 3 parts of wormwood, 2 parts of ginger, 3 parts of tuber fleeceflower stem, 5 parts of tea bran, 3 parts of mulberry leaf, 2 parts of apocynum venetum leaf and 2 parts of wild rice; the preparation method of the traditional Chinese medicine composition is the same as that of example 1.
Example 3
A traditional Chinese medicine composition is prepared from the following traditional Chinese medicine raw materials in parts by weight: 2 parts of wormwood, 1 part of ginger, 2 parts of tuber fleeceflower stem, 3 parts of tea bran, 2 parts of mulberry leaf, 1 part of apocynum venetum leaf and 1 part of wild rice; the preparation method of the traditional Chinese medicine composition is the same as that of example 1.
Examples 4-6 preparation of Hair loss prevention Hair growth shampoo
(1) The raw material composition is shown in table 1:
TABLE 1
(2) The preparation method comprises the following steps:
weighing the corresponding raw materials according to the mass percent, starting a stirring pot, adding deionized water, continuously adding cationic guar gum, stirring and heating to 45 ℃; adding AES for homogenizing for 10 minutes, stopping homogenizing, and continuing stirring for 20 minutes until the AES is completely dissolved; continuously heating to 75 ℃, adding the pearlescent sheet and CMEA, heating to above 80 ℃, stopping steam, keeping the temperature, stirring for 35 minutes, and then cooling; when the temperature is reduced to 60 ℃, adding sodium chloride and citric acid, and adding the traditional Chinese medicine composition and essence at 45 ℃; stopping stirring when the temperature of the materials in the pot is reduced to below 40 ℃, then sampling to measure the intermediate control index, discharging and packaging after meeting the quality intermediate control requirement, and thus obtaining the product.
Examples 7-9 preparation of Hair loss preventive conditioner
(1) The raw material formulation is shown in table 2:
TABLE 2
(2) The preparation method comprises the following steps:
weighing the corresponding raw materials according to the mass percentage, adding deionized water, hexadecyl trimethyl ammonium chloride and glycerol, heating to 70 ℃, then continuously adding monoglyceride, stearic acid, 16-18 alcohol, emulsified silicone oil and tween-80, stirring and homogenizing for 10min, then heating the reaction system to 85 ℃, stopping heating and continuously homogenizing for 10min, keeping the temperature and stirring for 10min, then cooling, adding the traditional Chinese medicine composition, the preservative and the essence when the temperature of the reaction system is reduced to 45 ℃, continuously cooling, stopping stirring when the temperature of materials in a pot is reduced to below 40 ℃, sampling, sending to a mass intermediate control room for measuring an intermediate control index, discharging and packaging after meeting the requirement of the intermediate control, thus obtaining the product.
Experimental example 1: infectious alopecia test
1.1 infectious alopecia test method
21 volunteers with infectious alopecia symptoms and more than 100 alopecia per day were selected to participate in the test, and were randomly and evenly divided into 7 groups, and the corresponding products were used for 1 time per day in a uniform guidance manner at a fixed time in the manner shown in the following table, and the blank control test was performed using commercially available conventional shampoo, and the fallen hairs were collected and the average integers were taken according to the usage time records shown in the following table, see table 3 below.
TABLE 3
1.2 conclusion of the experiment
Tests prove that the hair washing and caring product added with the traditional Chinese medicine composition has obvious effect on infectious alopecia symptoms, the alopecia symptoms are obviously improved within 45 days, the effect tends to be gentle after 45 days, and the improvement effect of the infectious alopecia symptoms is increased along with the increase of the addition amount of the traditional Chinese medicine composition within the testing time period.
Experimental example 2 Hair growth promoting test
2.1 Experimental animals: wistar rats are 8, half male and half female, numbered 1-8, and grouped into 8 groups.
2.2 Experimental materials: 5 m/v% minoxidil, the Chinese medicinal composition prepared in example 3 was prepared into aqueous solutions of 5 m/v%, 10 m/v% and 15 m/v%, respectively.
2.3 test methods: on the back of the mouse, the spine was used as a midline, the mouse was divided into 4 regions ABCD (2 cm. times.2 cm) from the head to the tail, each half was left and right, and after hair removal, 0.2ml of the test article was applied in the arrangement shown in Table 4 below, and the blank was applied with distilled water. After 21 days, a bunch of new hairs are pulled out from the smearing region, 10 longer hairs are selected by visual inspection and measured by a vernier caliper, and the average value is taken as the growth length value of the rat hairs in the region. The application area hair was carefully collected and weighed again as a rat hair growth weight value. The results are shown in Table 5.
TABLE 4 arrangement of applied test materials
TABLE 5 rat growth hair length and gross weight test results
| Region(s) | Wool length (mm) | Gross weight (mg) |
| 5% minoxidil | 12.74 | 45.58 |
| 5% of traditional Chinese medicine composition | 11.82 | 43.15 |
| 10% of traditional Chinese medicine composition | 15.25 | 49.66 |
| 15% of traditional Chinese medicine composition | 16.63 | 52.80 |
| Blank space | 11.29 | 28.61 |
2.4 conclusion of the experiment
Test results show that the traditional Chinese medicine composition has the effect of promoting hair growth, the effect is enhanced along with the increase of the dosage, the effect is obviously improved between 5 m/v% of the traditional Chinese medicine composition and 10 m/v% of the traditional Chinese medicine composition, and the improvement effect is reduced between 10 m/v% of the traditional Chinese medicine composition and 15 m/v% of the traditional Chinese medicine composition.
Finally, it should be noted that: the above examples are only intended to illustrate the technical solution of the present invention, but not to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; and such modifications or substitutions do not depart from the spirit and scope of the corresponding technical solutions of the embodiments of the present invention.
Claims (6)
1. The traditional Chinese medicine composition is characterized by being prepared from the following traditional Chinese medicine raw materials in parts by weight: 1-3 parts of wormwood, 0.5-2 parts of ginger, 1-3 parts of tuber fleeceflower stem, 2-5 parts of tea bran, 1-3 parts of mulberry leaf, 0.5-2 parts of apocynum venetum leaf and 0.5-2 parts of wild rice.
2. The traditional Chinese medicine composition according to claim 1, which is prepared from the following traditional Chinese medicine raw materials in parts by weight: 2 parts of wormwood, 1 part of ginger, 2 parts of tuber fleeceflower stem, 3 parts of tea bran, 2 parts of mulberry leaf, 1 part of apocynum venetum leaf and 1 part of wild rice.
3. A method for preparing the traditional Chinese medicine composition of any one of claims 1 to 2, which is characterized by comprising the following steps: weighing the traditional Chinese medicine components according to the proportion, crushing the traditional Chinese medicine components to more than 300 meshes, mixing the other medicines except the wild rice, adding water with the mass of 3-10 times of that of the wild rice, adding water at 70-90 ℃, carrying out reflux extraction twice for 2-4 h each time, collecting an extracting solution, concentrating the extracting solution at 40-60 ℃ under reduced pressure to obtain an extract with the density of 1.2-1.6 g/mL, and then mixing the extract with the crushed wild rice to obtain the anti-hair loss traditional Chinese medicine extract.
4. Use of the traditional Chinese medicine composition according to any one of claims 1-2 in preparation of a hair loss prevention and hair growth promotion daily chemical product, wherein the daily chemical product is one or more selected from shampoo, hair conditioner and soap.
5. The use of the traditional Chinese medicine composition in the preparation of anti-hair loss, hair growth and daily use chemicals according to claim 4, wherein the preparation method of the shampoo comprises the following steps:
s1 the shampoo is prepared from the following components in percentage by mass: 4-12% of a traditional Chinese medicine composition, 10-15% of fatty alcohol ether sodium sulfate (AES), 0.5-2.0% of a pearly-lustre sheet, 0.1-0.5% of cationic guar gum, 1.0-4.0% of Coconut Monoethanolamide (CMEA), 0.1-1.0% of essence, a proper amount of sodium chloride, a proper amount of citric acid and the balance of water, wherein the viscosity of the shampoo is greater than 0.4Pa.s at 25 ℃, and the pH value of the shampoo is 6-8;
the preparation method of S2 comprises the following steps: weighing the corresponding raw materials according to the mass percentage, starting a stirring pot, adding deionized water, continuously adding cationic guar gum, stirring and heating to 40-50 ℃; adding AES for homogenizing for 8-15 minutes, stopping homogenizing, and continuing stirring for 15-30 minutes until the AES is completely dissolved; continuously heating until the temperature rises to 65-78 ℃, adding the pearlescent sheet and CMEA, heating to above 80 ℃, stopping steam, keeping the temperature, stirring for 30-40 minutes, and then cooling; when the temperature is reduced to 50-70 ℃, adding sodium chloride and citric acid, and adding the traditional Chinese medicine composition and essence at 40-50 ℃; stopping stirring when the temperature of the materials in the pot is reduced to below 40 ℃, then sampling to measure the intermediate control index, discharging and packaging after meeting the quality intermediate control requirement, and thus obtaining the product.
6. The use of the traditional Chinese medicine composition in the preparation of hair loss prevention, hair growth promotion and daily use chemical products according to claim 4 is characterized in that the preparation method of the hair conditioner comprises the following steps:
s1 the hair conditioner is prepared from the following components in percentage by mass: 3.0-9.0% of a traditional Chinese medicine composition, 2.0-4.0% of monoglyceride, 1.0-3.0% of stearic acid, 1.0-4.0% of 16-18 alcohol, 0.5-2.0% of emulsified silicone oil, 2.0-5.0% of hexadecyl trimethyl ammonium chloride (namely cationic surfactant 1631), 800.1-1.0% of tween-800.0%, 3.0-7.0% of glycerol, 0.1-0.3% of a preservative, 0.1-0.5% of essence and the balance of water, wherein the pH value of the hair conditioner is 6.0-8.0 at 25 ℃;
the preparation method of S2 comprises the following steps: weighing the corresponding raw materials according to the mass percentage, adding deionized water, hexadecyl trimethyl ammonium chloride and glycerol, heating to 65-80 ℃, then continuously adding monoglyceride, stearic acid, 16-18 alcohol, emulsified silicone oil and tween-80, stirring and homogenizing for 8-15 min, then heating the reaction system to 80-90 ℃, stopping heating and continuously homogenizing for 8-15 min, keeping the temperature, stirring for 5-15 min, cooling, adding the traditional Chinese medicine composition, the preservative and the essence when the temperature of the reaction system is reduced to 40-50 ℃, continuously cooling, stopping stirring when the temperature of materials in a pot is reduced to below 40 ℃, sampling, sending to a mass intermediate control room for measuring an intermediate control index, discharging and packaging after meeting the requirement of the intermediate control, thus obtaining the product.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112979950A (en) * | 2021-03-04 | 2021-06-18 | 福建英嘉医疗科技有限公司 | Cationic active agent for repairing hair follicle and preparation method thereof |
| CN113304237A (en) * | 2021-05-17 | 2021-08-27 | 云南贺尔思细胞生物技术有限公司 | Repair liquid for promoting hair follicle regeneration and preparation method thereof |
| CN115252549A (en) * | 2022-07-12 | 2022-11-01 | 科辉智药生物科技(深圳)有限公司 | Composition for improving drug effect of hair growth active substance and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103040691A (en) * | 2013-01-25 | 2013-04-17 | 李海祥 | Tea bran, ginger and rice vinegar cream shampoo and preparation method thereof |
| CN104644515A (en) * | 2013-12-11 | 2015-05-27 | 柳州两面针股份有限公司 | Anti-hair-loss hair washing and caring agent |
-
2020
- 2020-09-16 CN CN202010974365.XA patent/CN111888457B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103040691A (en) * | 2013-01-25 | 2013-04-17 | 李海祥 | Tea bran, ginger and rice vinegar cream shampoo and preparation method thereof |
| CN104644515A (en) * | 2013-12-11 | 2015-05-27 | 柳州两面针股份有限公司 | Anti-hair-loss hair washing and caring agent |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112979950A (en) * | 2021-03-04 | 2021-06-18 | 福建英嘉医疗科技有限公司 | Cationic active agent for repairing hair follicle and preparation method thereof |
| CN113304237A (en) * | 2021-05-17 | 2021-08-27 | 云南贺尔思细胞生物技术有限公司 | Repair liquid for promoting hair follicle regeneration and preparation method thereof |
| CN115252549A (en) * | 2022-07-12 | 2022-11-01 | 科辉智药生物科技(深圳)有限公司 | Composition for improving drug effect of hair growth active substance and preparation method thereof |
| CN115252549B (en) * | 2022-07-12 | 2023-09-08 | 科辉智药生物科技（无锡）有限公司 | Composition for improving efficacy of hair-growing active substance and preparation method thereof |
| WO2024012291A1 (en) * | 2022-07-12 | 2024-01-18 | 科辉智药生物科技（无锡）有限公司 | Composition for improving efficacy of hair growth active substance and preparation method therefor |
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