JPH08295621A - Cosmetic containing extract of citrus fruits - Google Patents

Abstract

PURPOSE: To obtain a cosmetic having high safety, containing an extract of a citrus fruit, capable of reducing an amount of an antiseptic mixed or not using it at all. CONSTITUTION: This cosmetic contains an extract from seed-containing fruit or seed of a citrus fruit such as grapefruit, lemon, orange, kumquats, Citrus hassaku, mandarin, Citrus natsudaidai, Citrus iyo, sour orange, citron., Citrus sphaerocarpa, Citrus grandis, naval orange, Citrus reticulata, pomelo trifoliate orange, lime, Citrus medica L., etc. Consequently, the cosmetic containing an extract of a citrus fruit is extremely stable to pollution with a microorganism in a stage of distribution and use and has high safety to human body. The cosmetic shows synergistic effect by combined use with a common antiseptic and can reduce the amount of antiseptic mixed.

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to a cosmetic having an excellent antiseptic effect, which contains a citrus extract.

[0002]

2. Description of the Related Art In general, cosmetics are blended with one or several preservatives for the purpose of preventing deterioration of quality. Conventionally, such preservatives include phenol compounds such as phenol, chlorcresol, chlorxylenol, propylmethylphenol, resorcin, orthophenylphenol, paraoxybenzoic acid ester, thymol, cresol, and parachlorophenol, and also acids or Examples of these salts include benzoic acid, sodium benzoate, salicylic acid, sodium salicylate, dehydroacetic acid, sodium dehydroacetate, sorbic acid, potassium sorbate, and undecylenic acid monoethanolamide.
Examples of halides include trichlorocarbanilide, trifluoromethyldichlorocarbanilide, trichlorohydroxydiphenyl ether, and the like, and quaternary ammonium salts include benzalkonium chloride, benzethonium chloride, alkyltrimethylammonium chloride, cetylpyridinium chloride, and alkylisodoyl bromide. Quinolinium, domiphan bromide, alkyldiaminoethylglycine hydrochloride, amphoteric surfactant alkyldiaminoethylglycine, laurylaminoethylglycine, sodium lauroylsarcosine, other compounds chlorhexidine hydrochloride, chlorhexidine glucuronate, chlorobutanol, photosensitizer, thiram, chloramine T, Hinokitiol, phenoxyethanol, ethyl alcohol, 2-methyl-4-isothiazolin-3-one, 5-chloro-2-methyl-4-
Isothiazolin-3-one, germal, glidant,
Such as Dawicil. Among these, paraoxybenzoic acid ester and phenoxyethanol are widely used as preservatives for cosmetics, but they cause primary irritation and cosmetic rash, and it is said that the safety of the preservative itself is problematic.

[0003] On the other hand, grapefruit, lemon, orange, kumquat, Hakushu, Wenzhou mandarin orange, summer mandarin orange, Iyokan,
Antibacterial agents for citrus fruits such as orange, yuzu, caboch, sudachi, zabon, navel orange, ponkan, buntan, karatachi, lime, Buddha citrus, or their seeds
It is known that the antiseptic effect is exhibited at a low concentration.
(Japanese Patent Application Laid-Open No. 03-90008, Japanese Patent Application Laid-Open No. 02-24710
6, JP-A-04-346933, JP-A-04-2795
17) These are citrus pulps, seeds, and whole fruits extracted with ethanol, glycerin, etc., and the safety of the solvent itself used is known.

[0004] However, as an example of blending citrus fruits in cosmetics, it is known that its extract or fruit juice or fruit skin is used as a fragrance or fruit juice as a moisturizing agent for the skin. It has not been used as a preservative.

[0005]

SUMMARY OF THE INVENTION It is an object of the present invention to provide a cosmetic material which can sufficiently prevent quality deterioration due to microorganisms while solving the safety of conventional cosmetic materials.

[0006]

The present invention is a cosmetic having an excellent antiseptic effect, which contains a citrus extract.

The extract used in the present invention is grapefruit, lemon, orange, kumquat, hayaku, unshu mandarin orange, summer mandarin orange, Iyokan, orange, yuzu, kabosu, sudachi, zabon, navel orange, ponkan, buntan, karatachi. , Lime, citrus fruits such as Buddha citrus, fruit juice, seeds or a mixture thereof, and as an extraction solvent, methanol, ethanol, ethylene glycol, diethylene glycol, glycerin, diglycerin, propylene glycol, isopropanol, 1,3-butylene glycol,
One or a mixture of two or more selected from propylene glycol, isoprene glycol, acetone, ethyl ether, ethyl acetate, butyl acetate, benzene, hexane, petroleum ether or water is used. This extract may be a liquid dissolved in an extraction solvent, or may be pulverized by distilling off the extraction solvent, if necessary.

Further, these citrus fruits are edible, and unlike tropical fruits which generally contain a large amount of protease, they have almost no irritation to the mucous membranes. For example, it has been confirmed that the grapefruit seed extract has a high LD50 of 2.0 g / kg or more and is highly safe. (Food and development, VOL29, NO, 12)

The cosmetics used in the present invention are makeup soaps,
Face wash, shampoo, conditioner, hair dye, hair tonic,
Hairdressing, cosmetics for hair, cream, milky lotion, cream for shaving, suntan / sunblock cream, lotion, cologne, shaving lotion, suntan / sunblock lotion, cosmetic oil, suntan / sunblock oil, white powder,
Powder, foundation, perfume, pack, nail cream, enamel, enamel remover, eyebrow, blusher, eye cream, eye shadow, mascara, eyeliner, lipstick,
Examples include lip balms, brushes, and bath cosmetics.

When the citrus extract is blended in the cosmetic of the present invention, the blending amount is suitably 0.0001 to 20% by weight, particularly preferably 0.01 to 10% by weight.

Further, it can be used in combination with a conventional preservative for cosmetics, and the synergistic effect with the citrus extract can reduce the compounding amount of the preservative for cosmetics itself. As the preservative used in combination, as a phenol compound, phenol, chlorcresol, chlorxylenol, propylmethylphenol, resorcin, orthophenylphenol, paraoxybenzoic acid ester, thymol, cresol, parachlorophenol, and the like, or acids or these Examples of the salts include benzoic acid, sodium benzoate, salicylic acid, sodium salicylate, dehydroacetic acid, sodium dehydroacetate, sorbic acid, potassium sorbate, undecylenic acid monoethanolamide, and the like, and trichlorocarbanilide and trifluoromethyldiamine as halides. Chlorocarbanilide, trichlorohydroxydiphenyl ether, etc. can be used as quaternary ammonium salts such as benzalkonium chloride, benzethonium chloride, and alkyl trimethyl chloride. Monium, cetylpyridinium chloride, alkylisoquinolinium bromide, domiphane bromide, alkyldiaminoethylglycine hydrochloride, laurylaminoethylglycine, lauroylsarcosine sodium as amphoteric surfactant, chlorhexidine hydrochloride, chlorhexidine glucuronate, chlorobutanol as other compounds , Photosensitizer, thiram, chloramine T, hinokitiol,
Phenoxyethanol, ethyl alcohol, 2-methyl-4
Examples include-isothiazolin-3-one, 5-chloro-2-methyl-4-isothiazolin-3-one, germal, glidant, dawycil, protamine and the like. In addition to these general preservatives, alcohols such as ethanol, isopropanol, 1,3-butylene glycol, isoprene glycol, ethylene glycol, propylene glycol, etc. synergistically exhibit antiseptic effect, undecylenic acid glycerin monoester, caprin Examples thereof include acid glycerin monoester, caprylic acid glycerin monoester, caproic acid glycerin monoester, lauric acid glycerin monoester, and the like, and monoesters of fatty acids having 16 or less carbon atoms and glycerin.

In the present invention, the cosmetics produced are not limited to the ones to be incorporated in the cosmetic composition, except that one or more citrus extract is an essential component, and the production method is not limited. The law shall be obeyed. The ingredients of the cosmetic composition referred to herein are squalane, liquid paraffin, α-
Hydrocarbons such as olefin oligomers, paraffin wax, ceresin, microcrystalline wax, corn oil, avocado oil, persic oil, olive oil, beef tallow, mink oil and other animal and vegetable oils, isopropyl myristate,
Liquid and solid synthetic esters such as cetyl octanoate, isopropyl myristate, cetyl palmitate, jojoba oil,
Carnauba wax, candelilla wax, natural wax such as wax, beeswax, beeswax, glyceryl stearate, sorbitan stearate, polyoxyethylene sorbitan monooleate, polyoxyethylene glyceryl tristearate, polyoxyethylene lauryl ether, deca trioleate Glyceryl, sucrose monolaurate, surfactant such as polyoxyethylene hydrogenated castor oil, silicone oil or its derivative such as dimethylpolysiloxane, methylphenylpolysiloxane, fluorine resin such as perfluoropolyether, ethanol, isopropanol, ethylene glycol, Glycerin,
1,3-butylene glycol, propylene glycol,
Alcohols such as diglycerin, carboxyvinyl polymer, carrageenan, xanthan gum, sodium carboxymethyl cellulose, water-soluble polymer such as sodium hyaluronate, collagen, elastin, silk, protein such as lactoferrin and its hydrolyzate, titanium dioxide,
Zinc oxide, talc, mica, silicic acid anhydride, nylon powder, polyalkyl acrylate, alumina, iron oxide powder, etc., UV absorbers, vitamins, anti-inflammatory agents, amino acids and their derivatives, lecithin, coloring Refers to agents, fragrances, etc., and can be arbitrarily blended as necessary.

[0013]

EXAMPLES The present invention will be specifically described below with reference to examples, but the present invention is not limited to the examples.

In this example, as a representative example, the minimum inhibitory concentration of grapefruit extract against various strains (Table 1) and a challenge test in cosmetics were carried out, and the following results were obtained. In addition, in Example 2, the results were obtained by changing the total number of viable cells with time from Example 3 onward for 7 days for each bacterial species.

Example 1 The minimum inhibitory concentration was measured according to the Japanese Society of Chemotherapy.

[0016]

[Table 1]

Example 2 Lotion A Example Comparative Example (1) 1,3-butylene glycol 2.0% 2.0% (2) Polyoxyethylene hydrogenated castor oil (50 EO) 0.2 0.0. 2 (3) Trimethylglycine 1.0 1.0 (4) Grapefruit extract 0.3 0 (5) Perfume 0.05 0.05 0.05 (6) The total amount is 100 with purified water. Manufacturing method Components (1), (3), (4) and (6) were uniformly dissolved, and separately dissolved by warming components (2) and (5) were added to the former and solubilized as a sample. . The challenge test is E. coli, P.I. aeruginosa, B .; s
ubtilis, C.I. albicans, A .; night
A certain amount of r was inoculated into the product, and the number of bacteria was measured for 7 days.
The changes in the number of bacteria are shown in Table-2, Figure-1 and Figure-2.

[0018]

[Table 2]

[0019]

[Figure 1]

[0020]

FIG. 2

Example 3 Lotion B Example Comparative Example (1) Concentrated glycerin 5.0% 5.0% (2) Trimethylglycine 0.2 0.2 (3) Grapefruit extract 0.1 0 (4) Fragrance 0.07 0.07 (5) Polyoxyethylene hydrogenated castor oil 0.5 0.5 (6) Ethanol 5.0 5.0 (7) Methyl paraoxybenzoate 0.03 0.03 (8) Purified water The total amount is 100. Manufacturing method Components (1) to (3) and (7) and (8) were uniformly dissolved, and separately heated components of components (4) to (6) were added to the former, and the solubilized product was used as a specimen. did. Normally, 0.1 to 0.3% of methyl paraoxybenzoate can exert antibacterial activity, but the compounding amount of the component of the present invention could be reduced. However, the bacterial strain used for evaluation was a challenge test using the same one as in Example 2, but the number of measurement days was 2
The evaluation was made in 8 days. The results are shown in Table-3.

[0022]

[Table 3]

Example 4 Emulsion Example Comparative Example (1) Squalane 5.0% 5.0% (2) Olive oil 5.0 5.0 (3) Refined jojoba oil 2.5 2.5 (4) Rice bran wax 0.8 0.8 (5) Polyoxyethylene stearyl ether (30 EO) 1.0 1.0 (6) Polyoxyethylene cetyl ether (10 EO) 1.8 1.8 (7) Mono Sorbitan stearate 1.2 1.2 (8) Glyceryl monooleate 0.5 0.5 (9) Palmitic acid 1.0 1.0 (10) Triethanolamine 0.5 0.5 (11) Propylene glycol 6.0 6.0 (12) Xanthan gum 0.15 0.15 (13) Lemon extract 0.40 (14) Phenoxyethanol 0.1 0.1 (15) Water-soluble collagen 0.03 0.03 ( 6) and 100 total volume Perfume 0.1 0.1 (17) purified water. Manufacturing method Components (1) to (9) were uniformly dissolved at 82 ° C, and separately dissolved components (10) to (14) and (17) heated at 80 ° C were added to the former, emulsified and cooled. To do. The component (16) was added on the way, and the component (15) was further added at 35 ° C. to make a homogenized sample.

Example 5 Beauty Serum Example Comparative Example (1) Squalane 0.03% 0.03% (2) Cholesteryl hydroxystearate 0.02 0.02 (3) Polyoxyethylene hydrogenated castor oil (60EO) .) 1.0 1.0 (4) Perfume 0.05 0.05 (5) 1,3-butylene glycol 5.0 5.0 (6) Carboxyvinyl polymer 0.1 0.1 (7) Biohyalurone Sodium acid 0.02 0.02 (8) Sorbit solution 3.0 3.0 (9) L-arginine 0.1 0.1 (10) Sodium L-glutamate 0.25 0.25 (11) Placenta extract 0.2 0.2 (12) Hydrolyzed elastin 0.1 0.1 (13) Orange extract 0.3 0 (14) Phenoxyethanol 0.05 0.05 (15) With purified water The amount is referred to as 100. Manufacturing method Components (1) to (5) are heated and uniformly dissolved. Separately, the components (6) to (15) were uniformly dissolved, and the former was solubilized to obtain a product.

Example 6 Face Wash Cream Example Comparative Example (1) Stearic acid 1.5% 1.5% (2) Palmitic acid 0.5 0.5 (3) Myristic acid 20.0 20.0 (4) Lauric acid 8.0 8.0 (5) Propylene glycol 10.0 10.0 (6) Lauric acid diethanolamide 5.0 5.0 (7) Polyoxyethylene octyl 0.02 0.02 Dodecyl ether (15E. O.) 2.0 2.0 (8) Dibutylhydroxytoluene 0.15 0.15 (9) Potassium hydroxide 6.0 6.0 (10) Grapefruit extract 0.25 0 (11) Sodium benzoate 0 0.03 0.03 (15) Adjust the total volume to 100 with purified water. Manufacturing method Components (1) to (8) are heated and uniformly dissolved. Separately, the components (9) to (15) were heated and uniformly dissolved, and mixed with the former to be cooled to obtain a product.

Example 7 Shampoo Example Comparative Example (1) Lauryl Sulfate Triethanolamine 25.0% 25.0% (2) Polyoxyethylene Lauryl Ether Sodium Sulfate (2EO) 10.0 10.0 ( 3) Coconut oil fatty acid diethanolamide 5.0 5.0 (4) Lauramide amidopropyl betaine 10.0 10.0 (5) Ethylene glycol distearate 2.0 2.0 (6) Sodium chloride 1.0 1. 0 (7) Cationized cellulose 0.2 0.2 (8) Dibutylhydroxytoluene 0.15 0.15 (9) Grapefruit extract 0.40 0 (10) Sodium benzoate 0.10 0.10 (11) Make up to 100 with purified water. (12) Adjust the pH to 6.0 with citric acid. Manufacturing method Components (1) to (11) were heated and uniformly dissolved and cooled to obtain a product. Component (12) was used for pH adjustment.

Example 8 Rinsing Example Comparative Example (1) Distearyldimethylammonium chloride 2.5% 2.5% (2) Octyldodecanol 1.0 1.0 (3) Behenyl alcohol 1.5 1.5 ( 4) Polyoxyethylene stearyl ether (15EO) 2.0 2.0 (5) 1,3-butylene glycol 5.0 5.0 (6) Stearyl trimethyl ammonium chloride 2.5 2.5 2.5 (7) Hydrolyzed keratin 0.3 0.3 (8) Hydrolyzed soybean peptide 0.2 0.2 (9) Silicone emulsion 1.2 1.2 (10) Grapefruit extract 0.30 0 (11) Methyl paraoxybenzoate 0.05 0.05 (12) Propyl paraoxybenzoate 0.01 0.01 (13) Perfume 0.1 0.1 (14) Add 1 to the total amount with purified water. 00. Manufacturing method Components (1) to (5) are heated and uniformly dissolved. Separately, the components (6) to (12) heated and dissolved and the former are mixed and emulsified, followed by stirring and cooling. A component (13) is added on the way to obtain a product.

Example 9 Gel Example Comparative Example (1) 1,3-butylene glycol 1.0% 1.0% (2) Ethanol 20.0 20.0 (3) Polyether-modified silicone 1.5 1. 5 (4) Carboxyvinyl polymer 0.5 0.5 (5) Triethanolamine 0.6 0.6 (6) Lemon extract 0.30 (7) Purified water to make the total amount 100. Manufacturing method Components (1) to (7) were uniformly dissolved to obtain a product.

Example 10 Presto Powder Example Comparative Example (1) Mica Titanium 3.0 3.0 3.0 (2) Zinc Laurate 10.0 10.0 (3) Barium Sulfate 5.0 5.0 5.0 (4) Allantoin Dihydroxyaluminum 0.5 0.5 (5) White petrolatum 2.0 2.0 (6) Liquid paraffin 3.0 3.0 (7) Grapefruit extract 0.5 0 (8) Perfume 0.3 0.3 (9) Total amount to 100 with talc. Manufacturing method Components (1) to (9) were mixed, crushed and pressed on a gold plate to obtain a product. The above Examples 4 to 10 also showed excellent stability against both fungi and bacteria.

[0030]

EFFECT OF THE INVENTION The citrus extract-containing cosmetic composition of the present invention is extremely stable against microbial contamination at the distribution stage and at the time of use, and is highly safe for the human body. Furthermore, a synergistic effect was obtained by using it together with a general preservative, and it was possible to reduce the preservative compounding amount.

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[Procedure amendment]

[Submission date] August 29, 1995

[Procedure Amendment 1]

[Document name to be amended] Statement

[Name of item to be corrected] Brief description of the drawing

[Correction method] Change

[Correction content]

[Brief description of drawings]

FIG. 1 is a diagram showing changes in the number of viable bacteria in a lotion of Example.

FIG. 2 is a diagram showing changes in the viable cell count in a comparative lotion.

Claims (1)

[Claims] 1. A citrus extract, ie grapefruit,
Fruits containing citrus seeds selected from lemon, orange, kumquat, hakushu, unshu mandarin orange, summer mandarin orange, Iyokan, orange, yuzu, kabosu, sudachi, zabon, navel orange, ponkan, buntan, karatachi, lime, Buddhist citrus or A cosmetic comprising one or more kinds of extracts from seeds.