CN107137599A - A kind of anthocyanidin formula eye sticker and preparation method thereof - Google Patents

A kind of anthocyanidin formula eye sticker and preparation method thereof Download PDF

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Publication number
CN107137599A
CN107137599A CN201710222171.2A CN201710222171A CN107137599A CN 107137599 A CN107137599 A CN 107137599A CN 201710222171 A CN201710222171 A CN 201710222171A CN 107137599 A CN107137599 A CN 107137599A
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parts
anthocyanidin
eye sticker
eye
formulated
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彭亮宇
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/534Mentha (mint)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539Scutellaria (skullcap)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/56Loganiaceae (Logania family), e.g. trumpetflower or pinkroot
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/718Coptis (goldthread)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/80Scrophulariaceae (Figwort family)
    • A61K36/804Rehmannia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/898Orchidaceae (Orchid family)
    • A61K36/8984Dendrobium
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/70Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023Transdermal patches and similar drug-containing composite devices, e.g. cataplasms

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
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Abstract

Eye sticker is formulated the invention discloses a kind of anthocyanidin, includes the component of following parts by weight:2~3 parts of cowberry anthocyanidin extract solution, 2~5 parts of the coptis, 2~5 parts of radix scutellariae, 2~5 parts of the stem of noble dendrobium, 2~5 parts of ginseng ground, 2~5 parts of safflower, 2~5 parts of borneol, 2~3 parts of butterflybush flower, 2~3 parts of peppermint.The invention belongs to medical sanitary technology field, it specifically can prevent eye dry eyes lesion there is provided one kind, effectively alleviate eye strain, resist visual impairment, eye is moistened, alleviates eye dryness, anthocyanidin formula eye sticker significant for dry eye patients especially effect and preparation method thereof.

Description

A kind of anthocyanidin formula eye sticker and preparation method thereof
Technical field
The invention belongs to medical sanitary technology field, a kind of anthocyanidin formula eye sticker and preparation method thereof is specifically referred to.
Background technology
Xerophthalmia is very common illness, and the film that our eyeball surface continues to be formed by one layer of tear is takeed good care of, It has humidification, contributes to healing and the prevention eye infection of the wound of eye.The tear of ocular is moistened by lachrymal gland point Secrete, and the tear film outer layer of " water lock " is mainly made up of the lipid of Meibomian gland secretion, without this layer of lipid, it is easy that tear evaporates fast eyes It is dry.When exception occurs in the quality of tear, tear film can be caused to be damaged, cause eyes uncomfortable, or visual function obstacle, such as:Eyes are done It is puckery, photophobia anemophobia, it is rubescent itch, eyelid is heavy, secretion is more, blurred vision, has foreign body sensation, not clear shed tears.Especially steam Send out dry eyes too strong, have after different degrees of degenerative change, under external force factor effect, Meibomian gland lipid changes, and causes Lachrymal gland blocks compressing or stimulated, so as to produce a series of clinical symptoms such as ophthalmic uncomfortable.
Dry eyes are the most common symptoms of Most patients, and incidence is more than eighty per cant.Due to the popularization of computer terminal, ring Border, the pollution of air, cause dry eye patients more and more;Age also by person in middle and old age's gradually rejuvenation, or even in the teenager having Also with the presence of dry eye patients, severe patient can cause hypopsia or even blindness, have a strong impact on the physically and mentally healthy and normal life of patient It is living, patient is suffered untold misery.
Conventional dry eyes product has artificial tears etc. at present, and the artificial tears containing preservative only results in dry eye patients disease Shape increase, the artificial tears without preservative also simply cures the symptoms, not the disease.
The content of the invention
To solve above-mentioned existing problem, eye dry eyes lesion can be prevented the invention provides one kind, effectively alleviates eye tired Labor, resists visual impairment, moistens eye, alleviates eye dryness, and anthocyanidin significant for dry eye patients especially effect is formulated eye Patch and preparation method thereof.
The technical solution adopted by the present invention is as follows:A kind of anthocyanidin is formulated eye sticker, includes the component of following parts by weight:Cowberry 2~3 parts of anthocyanidin extract solution, 2~5 parts of the coptis, 2~5 parts of radix scutellariae, 2~5 parts of the stem of noble dendrobium, 2~5 parts of ginseng ground, 2~5 parts of safflower, 2~5 parts of borneol, 2~3 parts of butterflybush flower, 2~3 parts of peppermint.
Further, this programme anthocyanidin formula eye sticker, includes the component of following parts by weight:Cowberry anthocyanidin extract solution 2.5 parts, 3 parts of the coptis, 4 parts of radix scutellariae, 3 parts of the stem of noble dendrobium, 4 parts of ginseng ground, 3 parts of safflower, 4 parts of borneol, 2.5 parts of butterflybush flower, peppermint 2.5 Part.
Invention additionally discloses the preparation method that a kind of anthocyanidin is formulated eye sticker, comprise the following steps:
1) each component is weighed according to the weight part ratio of component;
2) coptis, radix scutellariae, the stem of noble dendrobium, ginseng ground, safflower, borneol, butterflybush flower and peppermint are dried, control drying temperature For 0~30 DEG C, dry by above-mentioned material co-grinding after finishing, cross 80 mesh sieves and obtain medicinal powder;
3) by above-mentioned medicinal powder and medical high molecular aquagel according to 1:50 weight part ratios stir, and obtain intermediate state eye sticker and coagulate Glue;
4) add cowberry anthocyanidin extract solution by weight in above-mentioned intermediate state eye sticker gel, stir eye sticker coagulate Glue, by eye sticker gel coating on back sheet, through drying, surface cure, cutting forming, polyethylene film covering in surface is produced This anthocyanidin is formulated eye sticker.
Further, in step 3) consumption of traditional Chinese medicine powder is 20~40g.
Further, in step 3) in medical high molecular aquagel by polyacrylate, G & W according to 1:10:10 Ratio is mixed.
Further, in step 4) in back sheet top layer non-woven fabrics area ratio/occupancy ratio be more than 60%.It is easy to eye sticker gel more Good absorption.
Obtained and had the beneficial effect that using the such scheme present invention:Anthocyanidin of the present invention is formulated eye sticker, gentle non-stimulated, can It is attached directly on periocualr skin, drug ingedient directly penetrates into eye skin, this anthocyanidin is formulated eye sticker and demonstrate,proved by clinical trial It is real, it can effectively prevent eye dry eyes lesion, alleviate eye strain, resist visual impairment, moisten eye, alleviate eye dryness, it is right It is especially notable in dry eye patients effect.
Embodiment
The technical scheme in the embodiment of the present invention will be clearly and completely described below, it is clear that described implementation Example is only a part of embodiment of the present invention, rather than whole embodiments.Based on the embodiment in the present invention, this area is common All other embodiment that technical staff is obtained under the premise of creative work is not made, belongs to the model that the present invention is protected Enclose.
A kind of embodiment 1, anthocyanidin is formulated eye sticker, includes the component of following parts by weight:Cowberry anthocyanidin extract solution 2.5 Part, 3 parts of the coptis, 4 parts of radix scutellariae, 3 parts of the stem of noble dendrobium, 4 parts of ginseng ground, 3 parts of safflower, 4 parts of borneol, 2.5 parts of butterflybush flower, 2.5 parts of peppermint.
A kind of anthocyanidin is formulated the preparation method of eye sticker, comprises the following steps:
1) each component is weighed according to the weight part ratio of component;
2) coptis, radix scutellariae, the stem of noble dendrobium, ginseng ground, safflower, borneol, butterflybush flower and peppermint are dried, control drying temperature For 0~30 DEG C, dry by above-mentioned material co-grinding after finishing, cross 80 mesh sieves and obtain medicinal powder;
3) by above-mentioned medicinal powder and medical high molecular aquagel according to 1:50 weight part ratios stir, and obtain intermediate state eye sticker and coagulate Glue;
4) add cowberry anthocyanidin extract solution by weight in above-mentioned intermediate state eye sticker gel, stir eye sticker coagulate Glue, by eye sticker gel coating on back sheet, through drying, surface cure, cutting forming, polyethylene film covering in surface is produced This anthocyanidin is formulated eye sticker.
A kind of embodiment 2, anthocyanidin is formulated eye sticker, includes the component of following parts by weight:3 parts of cowberry anthocyanidin extract solution, 4 parts of the coptis, 4 parts of radix scutellariae, 4 parts of the stem of noble dendrobium, 3 parts of ginseng ground, 4 parts of safflower, 4 parts of borneol, 3 parts of butterflybush flower, 2 parts of peppermint.
A kind of anthocyanidin is formulated the preparation method of eye sticker, comprises the following steps:
1) each component is weighed according to the weight part ratio of component;
2) coptis, radix scutellariae, the stem of noble dendrobium, ginseng ground, safflower, borneol, butterflybush flower and peppermint are dried, control drying temperature For 0~30 DEG C, dry by above-mentioned material co-grinding after finishing, cross 80 mesh sieves and obtain medicinal powder;
3) by above-mentioned medicinal powder and medical high molecular aquagel according to 1:50 weight part ratios stir, and obtain intermediate state eye sticker and coagulate Glue;
4) add cowberry anthocyanidin extract solution by weight in above-mentioned intermediate state eye sticker gel, stir eye sticker coagulate Glue, by eye sticker gel coating on back sheet, through drying, surface cure, cutting forming, polyethylene film covering in surface is produced This anthocyanidin is formulated eye sticker.
A kind of embodiment 3, anthocyanidin is formulated eye sticker, includes the component of following parts by weight:2 parts of cowberry anthocyanidin extract solution, 3 parts of the coptis, 2.5 parts of radix scutellariae, 3.5 parts of the stem of noble dendrobium, 3.5 parts of ginseng ground, 3.5 parts of safflower, 2.5 parts of borneol, 3 parts of butterflybush flower, peppermint 2 Part.
A kind of anthocyanidin is formulated the preparation method of eye sticker, comprises the following steps:
1) each component is weighed according to the weight part ratio of component;
2) coptis, radix scutellariae, the stem of noble dendrobium, ginseng ground, safflower, borneol, butterflybush flower and peppermint are dried, control drying temperature For 0~30 DEG C, dry by above-mentioned material co-grinding after finishing, cross 80 mesh sieves and obtain medicinal powder;
3) by above-mentioned medicinal powder and medical high molecular aquagel according to 1:50 weight part ratios stir, and obtain intermediate state eye sticker and coagulate Glue;
4) add cowberry anthocyanidin extract solution by weight in above-mentioned intermediate state eye sticker gel, stir eye sticker coagulate Glue, by eye sticker gel coating on back sheet, through drying, surface cure, cutting forming, polyethylene film covering in surface is produced This anthocyanidin is formulated eye sticker.
Anthocyanidin formula eye sticker disclosed by the invention, when specifically used, tears polyethylene film, applies eye acupuncture point, By Transdermal absorption, this eye sticker is only used for the skin of closed, three times per day, one time one patch, 30 minutes every time, each course for the treatment of 15 My god.The present invention is disposable product, must not be reused.After anthocyanidin formula eye sticker use of the present invention, suffer from for dry eyes Person's effect is especially notable, by clinical verification, and SIT, BUT and fluorescent staining classification before and after treatment group's treatment are respectively provided with significantly Sex differernce, this anthocyanidin eye sticker is used for light, moderate dry eyes determined curative effect.
Embodiments of the invention are the foregoing is only, are not intended to limit the scope of the invention, it is every to utilize this hair Equivalent structure or equivalent flow conversion that bright description is made, or directly or indirectly it is used in other related technology necks Domain, is included within the scope of the present invention.

Claims (6)

1. a kind of anthocyanidin is formulated eye sticker, it is characterised in that include the component of following parts by weight:Cowberry anthocyanidin extract solution 2~3 Part, 2~5 parts of the coptis, 2~5 parts of radix scutellariae, 2~5 parts of the stem of noble dendrobium, 2~5 parts of ginseng ground, 2~5 parts of safflower, 2~5 parts of borneol, butterflybush flower 2~3 parts, 2~3 parts of peppermint.
2. a kind of anthocyanidin formula eye sticker according to claim 1, it is characterised in that include the component of following parts by weight: 2.5 parts of cowberry anthocyanidin extract solution, 3 parts of the coptis, 4 parts of radix scutellariae, 3 parts of the stem of noble dendrobium, 4 parts of ginseng ground, 3 parts of safflower, 4 parts of borneol is close to cover Spend 2.5 parts, 2.5 parts of peppermint.
3. a kind of anthocyanidin is formulated the preparation method of eye sticker, it is characterised in that comprise the following steps:
1) each component is weighed according to the weight part ratio of component;
2) coptis, radix scutellariae, the stem of noble dendrobium, ginseng ground, safflower, borneol, butterflybush flower and peppermint are dried, it is 0 to control drying temperature ~30 DEG C, dry by above-mentioned material co-grinding after finishing, cross 80 mesh sieves and obtain medicinal powder;
3) by above-mentioned medicinal powder and medical high molecular aquagel according to 1:50 weight part ratios stir, and obtain intermediate state eye sticker gel;
4) cowberry anthocyanidin extract solution is added by weight in above-mentioned intermediate state eye sticker gel, stir to obtain eye sticker gel, By eye sticker gel coating on back sheet, through drying, surface cure, cutting forming, polyethylene film covering in surface produces this Anthocyanidin is formulated eye sticker.
4. a kind of anthocyanidin according to claim 3 is formulated the preparation method of eye sticker, it is characterised in that in step 3) Chinese medicine The consumption of powder is 20~40g.
5. a kind of anthocyanidin according to claim 3 is formulated the preparation method of eye sticker, it is characterised in that in step 3) traditional Chinese medical science With macromolecule hydrogel by polyacrylate, G & W according to 1:10:10 ratio is mixed.
6. a kind of anthocyanidin according to claim 3 is formulated the preparation method of eye sticker, it is characterised in that in step 4) the middle back of the body Lining top layer non-woven fabrics area ratio/occupancy ratio is more than 60%.
CN201710222171.2A 2017-04-07 2017-04-07 A kind of anthocyanidin formula eye sticker and preparation method thereof Pending CN107137599A (en)

Priority Applications (1)

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CN201710222171.2A CN107137599A (en) 2017-04-07 2017-04-07 A kind of anthocyanidin formula eye sticker and preparation method thereof

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Application Number Priority Date Filing Date Title
CN201710222171.2A CN107137599A (en) 2017-04-07 2017-04-07 A kind of anthocyanidin formula eye sticker and preparation method thereof

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109865016A (en) * 2019-03-28 2019-06-11 成都中医药大学 A kind of pharmaceutical composition and its preparation method and application for treating xerophthalmia
CN112546156A (en) * 2020-12-30 2021-03-26 北京国科惠眼科技有限公司 Traditional Chinese medicine composition for treating eyesight, preparation method, preparation and application thereof
CN113069508A (en) * 2021-04-02 2021-07-06 岳阳亮视嘉健康管理有限公司 Cowberry fruit anthocyanin formula eye patch and preparation method thereof

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109865016A (en) * 2019-03-28 2019-06-11 成都中医药大学 A kind of pharmaceutical composition and its preparation method and application for treating xerophthalmia
CN112546156A (en) * 2020-12-30 2021-03-26 北京国科惠眼科技有限公司 Traditional Chinese medicine composition for treating eyesight, preparation method, preparation and application thereof
CN113069508A (en) * 2021-04-02 2021-07-06 岳阳亮视嘉健康管理有限公司 Cowberry fruit anthocyanin formula eye patch and preparation method thereof

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Application publication date: 20170908

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