CN107137599A - A kind of anthocyanidin formula eye sticker and preparation method thereof - Google Patents
A kind of anthocyanidin formula eye sticker and preparation method thereof Download PDFInfo
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- CN107137599A CN107137599A CN201710222171.2A CN201710222171A CN107137599A CN 107137599 A CN107137599 A CN 107137599A CN 201710222171 A CN201710222171 A CN 201710222171A CN 107137599 A CN107137599 A CN 107137599A
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/56—Loganiaceae (Logania family), e.g. trumpetflower or pinkroot
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
- A61K36/8984—Dendrobium
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
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Abstract
Eye sticker is formulated the invention discloses a kind of anthocyanidin, includes the component of following parts by weight:2~3 parts of cowberry anthocyanidin extract solution, 2~5 parts of the coptis, 2~5 parts of radix scutellariae, 2~5 parts of the stem of noble dendrobium, 2~5 parts of ginseng ground, 2~5 parts of safflower, 2~5 parts of borneol, 2~3 parts of butterflybush flower, 2~3 parts of peppermint.The invention belongs to medical sanitary technology field, it specifically can prevent eye dry eyes lesion there is provided one kind, effectively alleviate eye strain, resist visual impairment, eye is moistened, alleviates eye dryness, anthocyanidin formula eye sticker significant for dry eye patients especially effect and preparation method thereof.
Description
Technical field
The invention belongs to medical sanitary technology field, a kind of anthocyanidin formula eye sticker and preparation method thereof is specifically referred to.
Background technology
Xerophthalmia is very common illness, and the film that our eyeball surface continues to be formed by one layer of tear is takeed good care of,
It has humidification, contributes to healing and the prevention eye infection of the wound of eye.The tear of ocular is moistened by lachrymal gland point
Secrete, and the tear film outer layer of " water lock " is mainly made up of the lipid of Meibomian gland secretion, without this layer of lipid, it is easy that tear evaporates fast eyes
It is dry.When exception occurs in the quality of tear, tear film can be caused to be damaged, cause eyes uncomfortable, or visual function obstacle, such as:Eyes are done
It is puckery, photophobia anemophobia, it is rubescent itch, eyelid is heavy, secretion is more, blurred vision, has foreign body sensation, not clear shed tears.Especially steam
Send out dry eyes too strong, have after different degrees of degenerative change, under external force factor effect, Meibomian gland lipid changes, and causes
Lachrymal gland blocks compressing or stimulated, so as to produce a series of clinical symptoms such as ophthalmic uncomfortable.
Dry eyes are the most common symptoms of Most patients, and incidence is more than eighty per cant.Due to the popularization of computer terminal, ring
Border, the pollution of air, cause dry eye patients more and more;Age also by person in middle and old age's gradually rejuvenation, or even in the teenager having
Also with the presence of dry eye patients, severe patient can cause hypopsia or even blindness, have a strong impact on the physically and mentally healthy and normal life of patient
It is living, patient is suffered untold misery.
Conventional dry eyes product has artificial tears etc. at present, and the artificial tears containing preservative only results in dry eye patients disease
Shape increase, the artificial tears without preservative also simply cures the symptoms, not the disease.
The content of the invention
To solve above-mentioned existing problem, eye dry eyes lesion can be prevented the invention provides one kind, effectively alleviates eye tired
Labor, resists visual impairment, moistens eye, alleviates eye dryness, and anthocyanidin significant for dry eye patients especially effect is formulated eye
Patch and preparation method thereof.
The technical solution adopted by the present invention is as follows:A kind of anthocyanidin is formulated eye sticker, includes the component of following parts by weight:Cowberry
2~3 parts of anthocyanidin extract solution, 2~5 parts of the coptis, 2~5 parts of radix scutellariae, 2~5 parts of the stem of noble dendrobium, 2~5 parts of ginseng ground, 2~5 parts of safflower,
2~5 parts of borneol, 2~3 parts of butterflybush flower, 2~3 parts of peppermint.
Further, this programme anthocyanidin formula eye sticker, includes the component of following parts by weight:Cowberry anthocyanidin extract solution
2.5 parts, 3 parts of the coptis, 4 parts of radix scutellariae, 3 parts of the stem of noble dendrobium, 4 parts of ginseng ground, 3 parts of safflower, 4 parts of borneol, 2.5 parts of butterflybush flower, peppermint 2.5
Part.
Invention additionally discloses the preparation method that a kind of anthocyanidin is formulated eye sticker, comprise the following steps:
1) each component is weighed according to the weight part ratio of component;
2) coptis, radix scutellariae, the stem of noble dendrobium, ginseng ground, safflower, borneol, butterflybush flower and peppermint are dried, control drying temperature
For 0~30 DEG C, dry by above-mentioned material co-grinding after finishing, cross 80 mesh sieves and obtain medicinal powder;
3) by above-mentioned medicinal powder and medical high molecular aquagel according to 1:50 weight part ratios stir, and obtain intermediate state eye sticker and coagulate
Glue;
4) add cowberry anthocyanidin extract solution by weight in above-mentioned intermediate state eye sticker gel, stir eye sticker coagulate
Glue, by eye sticker gel coating on back sheet, through drying, surface cure, cutting forming, polyethylene film covering in surface is produced
This anthocyanidin is formulated eye sticker.
Further, in step 3) consumption of traditional Chinese medicine powder is 20~40g.
Further, in step 3) in medical high molecular aquagel by polyacrylate, G & W according to 1:10:10
Ratio is mixed.
Further, in step 4) in back sheet top layer non-woven fabrics area ratio/occupancy ratio be more than 60%.It is easy to eye sticker gel more
Good absorption.
Obtained and had the beneficial effect that using the such scheme present invention:Anthocyanidin of the present invention is formulated eye sticker, gentle non-stimulated, can
It is attached directly on periocualr skin, drug ingedient directly penetrates into eye skin, this anthocyanidin is formulated eye sticker and demonstrate,proved by clinical trial
It is real, it can effectively prevent eye dry eyes lesion, alleviate eye strain, resist visual impairment, moisten eye, alleviate eye dryness, it is right
It is especially notable in dry eye patients effect.
Embodiment
The technical scheme in the embodiment of the present invention will be clearly and completely described below, it is clear that described implementation
Example is only a part of embodiment of the present invention, rather than whole embodiments.Based on the embodiment in the present invention, this area is common
All other embodiment that technical staff is obtained under the premise of creative work is not made, belongs to the model that the present invention is protected
Enclose.
A kind of embodiment 1, anthocyanidin is formulated eye sticker, includes the component of following parts by weight:Cowberry anthocyanidin extract solution 2.5
Part, 3 parts of the coptis, 4 parts of radix scutellariae, 3 parts of the stem of noble dendrobium, 4 parts of ginseng ground, 3 parts of safflower, 4 parts of borneol, 2.5 parts of butterflybush flower, 2.5 parts of peppermint.
A kind of anthocyanidin is formulated the preparation method of eye sticker, comprises the following steps:
1) each component is weighed according to the weight part ratio of component;
2) coptis, radix scutellariae, the stem of noble dendrobium, ginseng ground, safflower, borneol, butterflybush flower and peppermint are dried, control drying temperature
For 0~30 DEG C, dry by above-mentioned material co-grinding after finishing, cross 80 mesh sieves and obtain medicinal powder;
3) by above-mentioned medicinal powder and medical high molecular aquagel according to 1:50 weight part ratios stir, and obtain intermediate state eye sticker and coagulate
Glue;
4) add cowberry anthocyanidin extract solution by weight in above-mentioned intermediate state eye sticker gel, stir eye sticker coagulate
Glue, by eye sticker gel coating on back sheet, through drying, surface cure, cutting forming, polyethylene film covering in surface is produced
This anthocyanidin is formulated eye sticker.
A kind of embodiment 2, anthocyanidin is formulated eye sticker, includes the component of following parts by weight:3 parts of cowberry anthocyanidin extract solution,
4 parts of the coptis, 4 parts of radix scutellariae, 4 parts of the stem of noble dendrobium, 3 parts of ginseng ground, 4 parts of safflower, 4 parts of borneol, 3 parts of butterflybush flower, 2 parts of peppermint.
A kind of anthocyanidin is formulated the preparation method of eye sticker, comprises the following steps:
1) each component is weighed according to the weight part ratio of component;
2) coptis, radix scutellariae, the stem of noble dendrobium, ginseng ground, safflower, borneol, butterflybush flower and peppermint are dried, control drying temperature
For 0~30 DEG C, dry by above-mentioned material co-grinding after finishing, cross 80 mesh sieves and obtain medicinal powder;
3) by above-mentioned medicinal powder and medical high molecular aquagel according to 1:50 weight part ratios stir, and obtain intermediate state eye sticker and coagulate
Glue;
4) add cowberry anthocyanidin extract solution by weight in above-mentioned intermediate state eye sticker gel, stir eye sticker coagulate
Glue, by eye sticker gel coating on back sheet, through drying, surface cure, cutting forming, polyethylene film covering in surface is produced
This anthocyanidin is formulated eye sticker.
A kind of embodiment 3, anthocyanidin is formulated eye sticker, includes the component of following parts by weight:2 parts of cowberry anthocyanidin extract solution,
3 parts of the coptis, 2.5 parts of radix scutellariae, 3.5 parts of the stem of noble dendrobium, 3.5 parts of ginseng ground, 3.5 parts of safflower, 2.5 parts of borneol, 3 parts of butterflybush flower, peppermint 2
Part.
A kind of anthocyanidin is formulated the preparation method of eye sticker, comprises the following steps:
1) each component is weighed according to the weight part ratio of component;
2) coptis, radix scutellariae, the stem of noble dendrobium, ginseng ground, safflower, borneol, butterflybush flower and peppermint are dried, control drying temperature
For 0~30 DEG C, dry by above-mentioned material co-grinding after finishing, cross 80 mesh sieves and obtain medicinal powder;
3) by above-mentioned medicinal powder and medical high molecular aquagel according to 1:50 weight part ratios stir, and obtain intermediate state eye sticker and coagulate
Glue;
4) add cowberry anthocyanidin extract solution by weight in above-mentioned intermediate state eye sticker gel, stir eye sticker coagulate
Glue, by eye sticker gel coating on back sheet, through drying, surface cure, cutting forming, polyethylene film covering in surface is produced
This anthocyanidin is formulated eye sticker.
Anthocyanidin formula eye sticker disclosed by the invention, when specifically used, tears polyethylene film, applies eye acupuncture point,
By Transdermal absorption, this eye sticker is only used for the skin of closed, three times per day, one time one patch, 30 minutes every time, each course for the treatment of 15
My god.The present invention is disposable product, must not be reused.After anthocyanidin formula eye sticker use of the present invention, suffer from for dry eyes
Person's effect is especially notable, by clinical verification, and SIT, BUT and fluorescent staining classification before and after treatment group's treatment are respectively provided with significantly
Sex differernce, this anthocyanidin eye sticker is used for light, moderate dry eyes determined curative effect.
Embodiments of the invention are the foregoing is only, are not intended to limit the scope of the invention, it is every to utilize this hair
Equivalent structure or equivalent flow conversion that bright description is made, or directly or indirectly it is used in other related technology necks
Domain, is included within the scope of the present invention.
Claims (6)
1. a kind of anthocyanidin is formulated eye sticker, it is characterised in that include the component of following parts by weight:Cowberry anthocyanidin extract solution 2~3
Part, 2~5 parts of the coptis, 2~5 parts of radix scutellariae, 2~5 parts of the stem of noble dendrobium, 2~5 parts of ginseng ground, 2~5 parts of safflower, 2~5 parts of borneol, butterflybush flower
2~3 parts, 2~3 parts of peppermint.
2. a kind of anthocyanidin formula eye sticker according to claim 1, it is characterised in that include the component of following parts by weight:
2.5 parts of cowberry anthocyanidin extract solution, 3 parts of the coptis, 4 parts of radix scutellariae, 3 parts of the stem of noble dendrobium, 4 parts of ginseng ground, 3 parts of safflower, 4 parts of borneol is close to cover
Spend 2.5 parts, 2.5 parts of peppermint.
3. a kind of anthocyanidin is formulated the preparation method of eye sticker, it is characterised in that comprise the following steps:
1) each component is weighed according to the weight part ratio of component;
2) coptis, radix scutellariae, the stem of noble dendrobium, ginseng ground, safflower, borneol, butterflybush flower and peppermint are dried, it is 0 to control drying temperature
~30 DEG C, dry by above-mentioned material co-grinding after finishing, cross 80 mesh sieves and obtain medicinal powder;
3) by above-mentioned medicinal powder and medical high molecular aquagel according to 1:50 weight part ratios stir, and obtain intermediate state eye sticker gel;
4) cowberry anthocyanidin extract solution is added by weight in above-mentioned intermediate state eye sticker gel, stir to obtain eye sticker gel,
By eye sticker gel coating on back sheet, through drying, surface cure, cutting forming, polyethylene film covering in surface produces this
Anthocyanidin is formulated eye sticker.
4. a kind of anthocyanidin according to claim 3 is formulated the preparation method of eye sticker, it is characterised in that in step 3) Chinese medicine
The consumption of powder is 20~40g.
5. a kind of anthocyanidin according to claim 3 is formulated the preparation method of eye sticker, it is characterised in that in step 3) traditional Chinese medical science
With macromolecule hydrogel by polyacrylate, G & W according to 1:10:10 ratio is mixed.
6. a kind of anthocyanidin according to claim 3 is formulated the preparation method of eye sticker, it is characterised in that in step 4) the middle back of the body
Lining top layer non-woven fabrics area ratio/occupancy ratio is more than 60%.
Priority Applications (1)
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CN201710222171.2A CN107137599A (en) | 2017-04-07 | 2017-04-07 | A kind of anthocyanidin formula eye sticker and preparation method thereof |
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CN201710222171.2A CN107137599A (en) | 2017-04-07 | 2017-04-07 | A kind of anthocyanidin formula eye sticker and preparation method thereof |
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ID=59775153
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CN201710222171.2A Pending CN107137599A (en) | 2017-04-07 | 2017-04-07 | A kind of anthocyanidin formula eye sticker and preparation method thereof |
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109865016A (en) * | 2019-03-28 | 2019-06-11 | 成都中医药大学 | A kind of pharmaceutical composition and its preparation method and application for treating xerophthalmia |
CN112546156A (en) * | 2020-12-30 | 2021-03-26 | 北京国科惠眼科技有限公司 | Traditional Chinese medicine composition for treating eyesight, preparation method, preparation and application thereof |
CN113069508A (en) * | 2021-04-02 | 2021-07-06 | 岳阳亮视嘉健康管理有限公司 | Cowberry fruit anthocyanin formula eye patch and preparation method thereof |
-
2017
- 2017-04-07 CN CN201710222171.2A patent/CN107137599A/en active Pending
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109865016A (en) * | 2019-03-28 | 2019-06-11 | 成都中医药大学 | A kind of pharmaceutical composition and its preparation method and application for treating xerophthalmia |
CN112546156A (en) * | 2020-12-30 | 2021-03-26 | 北京国科惠眼科技有限公司 | Traditional Chinese medicine composition for treating eyesight, preparation method, preparation and application thereof |
CN113069508A (en) * | 2021-04-02 | 2021-07-06 | 岳阳亮视嘉健康管理有限公司 | Cowberry fruit anthocyanin formula eye patch and preparation method thereof |
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