CN113069508A

CN113069508A - Cowberry fruit anthocyanin formula eye patch and preparation method thereof

Info

Publication number: CN113069508A
Application number: CN202110359388.4A
Authority: CN
Inventors: 彭亮宇; 王丛香; 许茹诗
Original assignee: Yueyang Liangshijia Health Management Co ltd
Current assignee: Yueyang Liangshijia Health Management Co ltd
Priority date: 2021-04-02
Filing date: 2021-04-02
Publication date: 2021-07-06

Abstract

The invention discloses a cowberry anthocyanin formula eye mask which comprises eye mask gel, a back lining layer and a polyethylene film, wherein the eye mask gel is prepared by uniformly stirring cowberry anthocyanin extracting solution, chrysanthemum, dandelion, dendrobium, saffron, borneol, buddleja officinalis, mint and medical polymer hydrogel. The eye cream is mild and non-irritant, can be directly attached to skin around eyes, and the medicinal ingredients directly permeate into the skin around the eyes, moisten the eyes, relieve eye fatigue and dryness, can effectively prevent dry eye lesions of the eyes, resist vision deterioration, and have particularly remarkable effect on dry eye patients.

Description

Cowberry fruit anthocyanin formula eye patch and preparation method thereof

Technical Field

The invention belongs to the technical field of medical treatment and health, and particularly relates to a cowberry anthocyanin formula eye patch and a preparation method thereof.

Background

Dry eye is a very common condition, where our surface of the eye is continuously supported by a thin film formed by a layer of tear water, which has a moistening effect, helps the healing of trauma to the eye and prevents infection of the eye. The tear water that moistens the ocular surface is secreted by the lacrimal gland, while the outer layer of the tear film that "locks up" is mainly composed of the lipid secreted by the meibomian gland, without this layer of lipid, the tear water evaporates quickly and the eye is prone to dry. When the quality of the tear water is abnormal, it can cause tear film damage, eye discomfort, or visual dysfunction, such as: dry eyes, photophobia, aversion to wind, redness, itching, heavy eyelids, much secretion, blurred vision, foreign body sensation, unclear lacrimation and the like. Particularly, after the dry eye is excessively evaporated and degenerated to different degrees, meibomian gland lipid changes under the action of external force factors, so that lacrimal gland is blocked, pressed or stimulated, and a series of clinical symptoms such as eye discomfort and the like are generated.

Dry eye is the most common symptom in most patients, with an incidence of over eighths. Due to the popularization of computer terminals and the pollution of the environment and air, more and more patients with dry eye are caused; the age of the patient is gradually younger from the middle-aged and the elderly, even some patients with dry eyes exist in the young, severe patients can cause hypopsia and even blindness, the physical and mental health and normal life of the patients are seriously affected, and the patients are bitter.

The prior common dry eye products comprise artificial tears and the like, the artificial tears containing preservatives only can cause the symptoms of dry eye patients to increase, the artificial tears without preservatives only can treat the symptoms but not the root causes, and the artificial tears are not very convenient to use.

Disclosure of Invention

In order to solve the existing problems, the invention provides the cowberry anthocyanin formula eye patch which is convenient to use, moistens eyes, effectively relieves eye fatigue and dryness, can prevent dry eye lesions of the eyes, resists visual deterioration and has a remarkable effect on patients with dry eyes and the preparation method thereof.

The technical scheme adopted by the invention is as follows: an eye patch containing cowberry fruit anthocyanin formula comprises eye patch gel, back lining layer and polyethylene film, wherein the eye patch gel is prepared from cowberry fruit anthocyanin extract, flos Chrysanthemi, herba Taraxaci, herba Dendrobii, stigma croci Sativi, Borneolum Syntheticum, flos Buddlejae, herba Menthae and medical polymer hydrogel by stirring.

Further, the eye patch gel comprises the following components in parts by weight: 2-3 parts of cowberry anthocyanin extract, 2-5 parts of chrysanthemum, 2-5 parts of dandelion, 2-5 parts of dendrobium, 2-5 parts of saffron crocus, 2-5 parts of borneol, 2-3 parts of buddleja officinalis and 2-3 parts of mint.

Further, the eye patch gel comprises the following components in parts by weight: 2.5 parts of cowberry fruit anthocyanin extract, 3 parts of chrysanthemum, 4 parts of dandelion, 3 parts of dendrobium, 3 parts of saffron, 4 parts of borneol, 2.5 parts of buddleja officinalis and 2.5 parts of mint.

The invention also discloses a preparation method of the blueberry anthocyanin formula eye patch, which comprises the following steps:

1) weighing cowberry fruit anthocyanin extracting solution, chrysanthemum, dandelion, dendrobium, saffron, borneol, buddleja and mint according to the weight part ratio of the components;

2) mixing flos Chrysanthemi, herba Taraxaci, herba Dendrobii, stigma croci Sativi, Borneolum Syntheticum and flos Buddlejae, pulverizing, and sieving with 80 mesh sieve to obtain medicinal powder;

3) mixing the medicinal powder and medical polymer hydrogel according to the weight ratio of 1: stirring uniformly at a weight ratio of 50 parts to obtain an intermediate eye mask gel;

4) adding the mint and the cowberry anthocyanin extracting solution into the intermediate state eye patch gel according to the weight part, uniformly stirring to obtain the eye patch gel, coating the eye patch gel on a back lining layer, drying, curing the surface, cutting and forming, and covering the surface with a polyethylene film to obtain the cowberry anthocyanin formula eye patch.

Further, in step 3), the traditional Chinese medicine polymer hydrogel is prepared from polyacrylate, glycerol and water according to the weight ratio of 1: 10: 10, and mixing the components in a ratio of 10.

Further, the mint is added in the step 4), and then the cowberry fruit anthocyanin extracting solution is added.

Further, the area occupancy rate of the non-woven fabric of the surface layer of the back lining layer in the step 4) is more than 60 percent.

In the invention, the cowberry anthocyanin extracting solution is derived from procyanidine of medical plant cowberry, is a polyphenol compound and mainly comprises anthocyanins such as anthocyanin-3-galactoside, anthocyanin-3-arabinofuranoside and paeonin-3-arabinofuranoside. Has antiinflammatory, antioxidant, and free radical scavenging effects, and can inhibit synthesis and release of inflammatory factors such as histamine, 5-hydroxytryptamine, prostaglandin, and leukotriene, and can be used for treating diabetes, blurred retina, cataract, glaucoma, degenerative speckle, phlebotomy, and ocular diseases such as subhyaloid hemorrhage.

The flos Chrysanthemi is dry capitula of Compositae. Bitter and sweet in taste, slightly cold in nature. It enters lung and liver meridians. The efficacy is as follows: dispel wind and clear heat, pacify liver and improve vision, clear heat and remove toxicity.

When herba Taraxaci is used as Chinese medicinal material, the whole plant with root is harvested in late autumn, and the mud is removed and dried in the sun for further use. Sweet in nature and taste, slightly bitter and cold. It enters liver and stomach meridians. Has diuretic, laxative, jaundice treating, and gallbladder promoting effects.

Dendrobe, medicinal plant, sweet, light, slightly salty and cold in nature and flavor, enters stomach, kidney and lung meridians. To nourish stomach, promote the production of body fluid, nourish yin and clear heat. Can be used for treating yin deficiency and fluid deficiency, dry mouth, polydipsia, anorexia, retching, asthenic fever after disease, and dim and unclear vision.

The dry stigma of saffron has sweet and neutral taste, and can promote blood circulation to disperse blood clots, disperse stagnation and relieve pain.

The borneol is colorless transparent or white semitransparent flaky crisp crystals; fragrant smell, pungent and cool taste; heart, liver and lung meridians entered; has effects of inducing resuscitation, refreshing mind, clearing away heat, removing toxic substances, improving eyesight, and eliminating nebula.

Flos Buddlejae, dried bud and inflorescence of Buddleja officinalis of Loganiaceae. Sweet in nature and taste, slightly cold. It enters liver meridian. The efficacy is as follows: clear heat and purge fire, nourish liver to improve vision, remove nebula.

The mint and the whole herb are used as the medicine for treating cold, fever, sore throat, headache and conjunctival congestion.

The synergistic effect of the components of the invention is as follows: the cowberry anthocyanin extract is derived from procyanidin of medical plant cowberry, and has biological effects of anti-inflammation, antioxidation and the like, and can effectively inhibit the release of ocular surface inflammatory factors and relieve the damage of oxidative stress reaction on ocular surface cells, improve the stability of tear film and improve the dry eye symptom to a certain extent. In addition, the eye patch gel as a drug carrier is applied to the skin around the eyes at night, and can play a certain role in keeping moisture and reducing tear evaporation due to the high water content in addition to the function of continuously releasing the drug. And the chrysanthemum, the dandelion, the dendrobium, the saffron and the pale butterflybush flower are absorbed through skin penetration, the cowberry anthocyanin is volatilized to eye cornea with heat, the cowberry anthocyanin can promote the regeneration of rhodopsin in eyes, and the mint can stimulate human eye gland cold receptors and increase the tear secretion.

By adopting the scheme, the invention has the following beneficial effects: the cowberry anthocyanin formula eye patch disclosed by the invention is mild, has no stimulation, is convenient to use, can be directly attached to skin around eyes, and medicinal ingredients can directly permeate into eye skin, moisten eyes, relieve eye fatigue and dryness, effectively prevent dry eye lesions of eyes, resist vision deterioration, and have a particularly remarkable effect on dry eye patients.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

The blueberry anthocyanin extract is Procyanidins (PC) extracted from medical plants, namely cowberry.

The flos Chrysanthemi is obtained by picking dry cephalanthus of Compositae, and drying.

The herba Taraxaci is prepared by digging whole plant with root in late autumn, removing mud, and sun drying.

And (4) taking stems of dendrobium, and drying for later use.

The stigma croci Sativi is prepared by picking the upper part and stigma of stigma croci Sativi of Iridaceae, and oven drying.

The Borneolum Syntheticum is prepared from stems and leaves of blumea balsamifera of Compositae or branches and leaves of Cinnamomum camphora of Lauraceae by steam distillation and recrystallization.

Flos Buddlejae is prepared by collecting dried bud and inflorescence of flos Buddlejae of Loganiaceae, and drying.

Herba Menthae, drying herba Menthae.

Example 1

1) Respectively taking 25g of cowberry fruit anthocyanin extract, 30g of chrysanthemum, 40g of dandelion, 30g of dendrobium, 30g of saffron, 40g of borneol, 25g of buddleja officinalis and 25g of mint;

2) mixing polyacrylate, glycerol and water in a weight ratio of 1: 10: 10 to prepare the medical polymer hydrogel,

3) mixing flos Chrysanthemi, herba Taraxaci, herba Dendrobii, stigma croci Sativi, Borneolum Syntheticum and flos Buddlejae, pulverizing, and sieving with 80 mesh sieve to obtain medicinal powder;

4) mixing the medicinal powder and medical polymer hydrogel according to the weight ratio of 1: stirring uniformly at a weight ratio of 50 to obtain an intermediate eye mask gel;

5) adding 25g of mint and 25g of cowberry anthocyanin extracting solution into the intermediate state eye patch gel, uniformly stirring to obtain the eye patch gel, coating the eye patch gel on a back lining layer, drying, curing the surface, cutting and forming, and covering the surface with a polyethylene film to obtain the cowberry anthocyanin formula eye patch.

Example 2

1) Respectively taking 30g of cowberry fruit anthocyanin extract, 40g of chrysanthemum, 40g of dandelion, 40g of dendrobium, 40g of saffron, 40g of borneol, 30g of buddleja officinalis and 20g of mint;

5) and adding 20g of mint and 30g of cowberry anthocyanin extracting solution into the intermediate state eye patch gel, uniformly stirring to obtain the eye patch gel, coating the eye patch gel on a back lining layer, drying, curing the surface, cutting and forming, and covering the surface with a polyethylene film to obtain the cowberry anthocyanin formula eye patch.

Example 3

1) 20g of cowberry fruit anthocyanin extract, 30g of chrysanthemum, 25g of dandelion, 35g of dendrobium, 35g of saffron, 25g of borneol, 30g of buddleja officinalis and 20g of mint;

5) and adding 20g of mint and 20g of cowberry anthocyanin extracting solution into the intermediate state eye patch gel, uniformly stirring to obtain the eye patch gel, coating the eye patch gel on a back lining layer, drying, curing the surface, cutting and forming, and covering the surface with a polyethylene film to obtain the cowberry anthocyanin formula eye patch.

The invention discloses a cowberry anthocyanin formula eye patch, which is specifically used for tearing a polyethylene film, applying the polyethylene film to an eye acupoint, achieving a treatment effect by transdermal absorption and volatilizing anthocyanin to an eye cornea under heat, and stimulating a human cold receptor and a lacrimal gland to increase tears by reducing the temperature around the eye skin. The eye patch is only used for closed skin, and is applied twice a day, one patch is used for 30 minutes each time, and each treatment course is 15 days.

The invention examines the action effect of the blueberry anthocyanin formula eye patch through the clinical research of 8 hospitals in the group of Aier ophthalmic hospitals:

the clinical research applies the cowberry fruit anthocyanin formula eye patch, namely the 1g/L anthocyanin eye patch referred to later, to light and moderate dry eyes, takes the artificial tears of the traditional treatment medicine of the dry eyes as a contrast, and carries out multi-center research in 8 hospitals in the Aier eye hospital group, aiming at observing the improvement effect of the 1g/L anthocyanin eye patch on the dry eyes and providing a choice for the treatment of the dry eyes.

Study object

The clinical research collects light and moderate dry eye patients who have a diagnosis in 8 Aier ophthalmology hospitals such as Changsha, Chongqing, Wuhan and Shenyang in 2016-10-2017 in 04, 40 eyes in each hospital are 80, and the patients are divided into 20 eyes in an eye protection plaster group and 40 eyes in an artificial tear group according to a digital random table method. 8 hospitals had 640 eyes in total, eye protection patch group had 160 eyes in total, 320 eyes in total, and artificial tear group had 160 eyes in total, 320 eyes. The average age of the eye patch group is 36.55 + -13.20 years, wherein 74 men and 86 women; the average age of the artificial tear group was 35.68 ± 14.05 years, with 71 men and 89 women. The average age and gender of the patients between the two groups were proportional and the differences were statistically insignificant (P > 0.05). Subject inclusion criteria were: (1) diagnosing mild and moderate dry eyes according to the common recognition of dry eye experts in China in 2013, wherein the score of fluorescein staining in any quadrant of the cornea is more than 2 and is not included; (2) incoordination with other ocular surface disorders; (3) no ocular surgical history within approximately 3 mo; (4) no other eye drops are used within 1mo except for artificial tears; (5) artificial tears are being used which undergo a 1wk elution period; (6) the person wearing the contact lens needs to stop wearing the contact lens by more than 2wk and does not wear the contact lens during the research period; (7) age: 18-70 years old.

Method of treatment

The eye protection paste group continuously uses 1g/L anthocyanin eye protection paste for more than 6h when two eyes sleep every night, does not use other eye drops in the research period, and lasts for 14 d; the artificial tear group was applied to both eyes with preservative-free polyvinyl alcohol eye solution for 4 times per day for 14 days.

Evaluation of therapeutic Effect

Two groups of patients underwent 2 efficacy evaluations before treatment and after 14 days of continuous treatment, including: (1) ocular Surface Disease Index (OSDI) questionnaire score: the number of the problems is 12, each problem is scored according to the severity degree and is 0-4, the total score is 0-100, and the larger the score is, the more serious the ocular surface symptoms of the patient are; (2) tear film break-up time: detecting non-invasive first tear film break-up time (NITBUTf) and average tear film break-up time (NITBUTav) by using an Oculus eye chart comprehensive analyzer; (3) tear secretion test (Schirmer I test, SIt): placing 5mm 35mm tear secretion filter paper strip at the junction of the middle and outer 1/3 of conjunctival sac under the tested eye, observing the patient to look down or slightly close the eye, taking out the filter paper after 5min, and measuring the wet length.

Statistical analysis

Statistical analysis was performed using SPSS19.0 statistical software, and the measurements were normally distributed by Shapiro-Wilk test and expressed as mean in standard deviation (x. + -.s). Data differences between the two groups were compared using the independent sample t-test, and differences between the groups before and after treatment were compared using the paired sample t-test. Differences of P <0.05 were statistically significant.

OSDI questionnaire scores before and after treatment in both groups patients the comparative differences in OSDI questionnaire scores between the groups before and after treatment were statistically significant (P <0.001), and were significantly reduced after treatment compared to before treatment. Comparison of differences between the pre-treatment and post-treatment groups for OSDI questionnaire scores in both groups was not statistically significant (P >0.05), see table 1.

NITBUTf and NITBUTav values before and after treatment of two groups of patients NITBUTf and NITBUTav values of two groups of patients have statistical significance (P is less than 0.001) compared with the group before and after treatment, and are obviously improved after treatment compared with the group before treatment. The comparison between NITBUTf, NITBUTav values of two groups of patients and the comparison between the groups before and after treatment have no statistical significance (P >0.05), which is shown in tables 2 and 3.

SIt values before and after treatment in both groups patients the comparative differences in SIt values in both groups between pre-and post-treatment groups were not statistically significant (P > 0.05). Comparison of the SIt values between the pre-treatment and post-treatment groups for both groups of patients was not statistically significant (P >0.05), see Table 4.

Conclusion of the study

In the study, after the eye-protecting patch group and the artificial tear group are treated at 2wk, the dry eye symptoms and tear film rupture time of two groups of patients are obviously improved compared with those before treatment, and the effects of the two groups of patients after treatment are not obviously different. At present, the artificial tears are first-line medicines for treating dry eye, and the artificial tears used in the control group of the research are preservative-free polyvinyl alcohol eye drops, and the effective treatment effect on the dry eye is proved by the previous researches. The research result shows that the 1g/L anthocyanin eye protection paste has a treatment effect similar to that of artificial tears for light and moderate dry eyes, can effectively improve the dry eye symptom and improve the tear film stability, but has no obvious improvement effect on the tear secretion function, the treatment period in the research is short, and whether the tear secretion function can be improved through longer-term treatment of the 1g/L anthocyanin eye protection paste is in need of further clinical observation. In a word, the 1g/L anthocyanin eye protection patch has the effects of improving dry eye symptoms and improving the stability of tear film, the use method is that the patch is applied to eyelid skin during sleep at night, the day work and life of a patient are not influenced, the patch can be used as a substitute or supplement of artificial tears to a certain extent, convenience is provided for the patient who is inconvenient to carry and use the artificial tears, and a choice is provided for light and moderate dry eye patients.

The beneficial effects obtained by adopting the scheme of the invention are as follows: the cowberry anthocyanin formula eye patch disclosed by the invention is mild and non-irritant, is convenient to use, can be directly attached to skin around eyes, and medicinal ingredients directly permeate into eye skin, moisten eyes, relieve eye fatigue and dryness, can effectively prevent dry eye lesions of eyes, resist vision loss, and have a particularly remarkable effect on dry eye patients.

The above description is only an embodiment of the present invention, and not intended to limit the scope of the present invention, and all modifications of equivalent structures and equivalent processes, which are made by the present specification, or directly or indirectly applied to other related technical fields, are included in the scope of the present invention.

Claims

1. The blueberry anthocyanin formula eye patch is characterized in that: the eye patch gel is prepared by uniformly stirring cowberry anthocyanin extract, chrysanthemum, dandelion, dendrobium, saffron, borneol, buddleja officinalis, mint and medical polymer hydrogel.

2. The blueberry anthocyanin formulation eye patch as recited in claim 1, wherein: the eye patch gel comprises the following components in parts by weight: 2-3 parts of cowberry anthocyanin extract, 2-5 parts of chrysanthemum, 2-5 parts of dandelion, 2-5 parts of dendrobium, 2-5 parts of saffron crocus, 2-5 parts of borneol, 2-3 parts of buddleja officinalis and 2-3 parts of mint.

3. The blueberry anthocyanin formulation eye patch as recited in claim 1, wherein: the eye patch gel comprises the following components in parts by weight: 2.5 parts of cowberry fruit anthocyanin extract, 3 parts of chrysanthemum, 4 parts of dandelion, 3 parts of dendrobium, 3 parts of saffron, 4 parts of borneol, 2.5 parts of buddleja officinalis and 2.5 parts of mint.

4. The method for preparing the cowberry fruit anthocyanin formula eye patch as claimed in any one of claims 1 to 3, wherein the method comprises the following steps: the method comprises the following steps:

5. The preparation method of the cowberry fruit anthocyanin formula eye patch as claimed in claim 4, wherein the preparation method comprises the following steps: in the step 3), the traditional Chinese medicine polymer hydrogel is prepared from polyacrylate, glycerol and water according to the weight ratio of 1: 10: 10, and mixing the components in a ratio of 10.

6. The preparation method of the cowberry fruit anthocyanin formula eye patch as claimed in claim 4, wherein the preparation method comprises the following steps: in the step 4), the mint is firstly added, and then the cowberry fruit anthocyanin extracting solution is added.

7. The preparation method of the cowberry fruit anthocyanin formula eye patch as claimed in claim 4, wherein the preparation method comprises the following steps: in the step 4), the area occupancy rate of the surface layer non-woven fabric of the back lining layer is more than 60 percent.