CN105055936A - Traditional Chinese medicine for treating primary angle closed glaucoma and preparation method of traditional Chinese medicine - Google Patents

Abstract

The invention discloses a traditional Chinese medicine for treating primary angle closed glaucoma and a preparation method of the traditional Chinese medicine. The traditional Chinese medicine comprises the following various raw herbal materials: macrostachys uraria herb, cyclea polytata, humulus scandens, alpine yarrow fruit, roots of coix lachryma-jobi L. var. ma-yuen Stapf., creeping oxalis, stephanotis, bitter citrus immature flower, liquorice tails, buckeye, pummelo seed, tsingling bergenia rhizome, siberian saltbush fruit, tigergrass and needle juniper. The traditional Chinese medicine has the advantages that with the aid of operative treatment of western medicines, the traditional Chinese medicine for treating the primary angle closed glaucoma has a good curative effect and little side effects according to the traditional theory of traditiona chinese medicines in China; and intraocular pressure of a patient can be controlled well on the basis of operative treatment, and injury of glaucoma optic nerve damage is prevented and treated, so that glaucoma can be treated well.

Description

A kind of Chinese medicine for the treatment of primary angle-closure glaucoma and preparation method thereof

Technical field

The present invention relates to pharmaceutical technology, particularly a kind of Chinese medicine for the treatment of primary angle-closure glaucoma and preparation method thereof.

Background technology

Glaucoma refers to that intraocular pressure is interrupted or continues a kind of oculopathy of raising, and lasting Bulbi hypertonia bring infringement can to eyeball each several part tissue and visual function, and as treated not in time, the visual field can total loss and arrive blind.Glaucoma is one of three large diseases causing blindnesses causing the mankind blind, and total crowd's sickness rate is 1%, within 45 years old, is 2% later.

Glaucoma is mainly divided into congenital glaucoma, primary glaucoma, secondary glaucoma and mixed glaucoma.Primary glaucoma can be divided into primary open angle glaucoma and primary angle-closure glaucoma again.Primary angle-closure glaucoma can also be further divided into acute angle closure glaucoma and chronic angle closure glaucoma.Acute angle closure glaucoma: the violent ophthalmic bloated headache that performance breaks out, vision falls sharply, eyeball as hard as flint, conjunctival congestion, nausea and vomiting, constipation, blood pressure raises, now General Symptoms is heavier is easily misdiagnosed as gastroenteritis, encephalitis, the pathological changes such as nervous headache, no light perception as blind as a bat is got final product as can not get timely diagnosis and treatment 24-48 hour, now claim " fulminant type glaucoma ", but there is some patients gently strong to pain tolerance clinically, only show as eye socket and ophthalmic uncomfortable, very then eye is without any symptom, and be transferred to forehead, ear, maxillary sinus, portion's pain such as tooth, acute angle closure glaucoma, actually be because chronic angle closure glaucoma delays repeatedly.Chronic angle closure glaucoma: show as eye dry and astringent, tired uncomfortable, distending pain; blurred vision or visual deterioration, iridization, dizzy pain; insomnia, blood pressure raises, and can alleviate after rest; some patients are without any symptom and blind, and during inspection, intraocular pressure can normally or fluctuation; or not too high about 20-30mmhg; optical fundus in early days can be normal, and this kind of is the most easily by mistaken diagnosis, and recurrent exerbation angle of anterior chamber like this can form fulminant type glaucoma once adhesion is closed.

At present, doctor trained in Western medicine mainly adopt medicine, operative treatment or both combine method.Medicine can increase the output of aqueous humor, or reduces the generation of ophthalmic aqueous humor.Most of case can control the intraocular pressure several years safely by medicine.Glaucomatous Drug therapy has much different intensity and combination, and most drug treatment has certain side effect.Doctor generally can attempt producing best therapeutic effect with minimum medicine, and minimum medicine produces minimum side effect.Drug therapy is necessary administration every day usually, keeps it in mind every day by prescriptions, is necessary to control intraocular pressure.Operation is the glaucomatous way of another kind for the treatment of, and operative treatment has its adaptability and limitation, and any operation always occurs the danger of complication.Except costly, to the condition of operation, especially the technical merit of doctor has higher requirement.Operative treatment just rests in the treatment to " disease " in addition, do not have to solve " because of " problem, thoroughly do not change eye microcirculation, therefore still there is the possibility of recurrence.Perform the operation and treating in glaucomatous process and can control intraocular pressure, stop visual function to damage further.But Post operation may occur that intraocular pressure controls bad or buoyant situation, and postoperative various complication is also very common.In open angle glaucoma, only have the medicine when maximal dose not control intraocular pressure, or just consider operation when patient is impatient at the Drug therapy controlling intraocular pressure.But angle closure glaucoma advocates early operation.

Summary of the invention

Technical problem to be solved by this invention is, provides a kind of Chinese medicine for the treatment of primary angle-closure glaucoma and preparation method thereof, Chinese medicine of the present invention, coordinates the operative treatment of doctor trained in Western medicine, and to treatment primary angle-closure glaucoma determined curative effect, side effect is little.

In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicine for the treatment of primary angle-closure glaucoma, wherein: described Chinese medicine comprises following raw medicinal material: Herba urariae macrostachyae, Radix Ilicis Asprellae rattan, Herba humuli scandentis, Fructus achilleae, Radix Coicis, Herba Oxalidis Corniculatae, Radix Stephaniae Cepharanthae, Citrus aurantium L. var. amara Engl., Radix Glycyrrhizae slightly, Semen Aesculi, Semen Citri grandis, Rhizoma Bergeniae scopulosae, Fructus Atriplicis Sibiricae, Herba Thysanolaenae maximae and Juniperus rigida Sieb.et Zucc..

In described Chinese medicine, the ratio of weight and number of each raw medicinal material is as follows: Herba urariae macrostachyae 8 ~ 18 parts, 10 ~ 20 parts, Radix Ilicis Asprellae rattan, Herba humuli scandentis 10 ~ 20 parts, Fructus achilleae 15 ~ 25 parts, Radix Coicis 20 ~ 30 parts, Herba Oxalidis Corniculatae 10 ~ 20 parts, Radix Stephaniae Cepharanthae 5 ~ 15 parts, Citrus aurantium L. var. amara Engl. 10 ~ 20 parts, slightly 20 ~ 30 parts, Radix Glycyrrhizae, Semen Aesculi 10 ~ 20 parts, Semen Citri grandis 10 ~ 20 parts, 15 ~ 25 parts, Rhizoma Bergeniae scopulosae, Fructus Atriplicis Sibiricae 20 ~ 30 parts, Herba Thysanolaenae maximae 20 ~ 30 parts and Juniperus rigida Sieb.et Zucc. 20 ~ 30 parts.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: Herba urariae macrostachyae 9 ~ 14 parts, 15 ~ 20 parts, Radix Ilicis Asprellae rattan, Herba humuli scandentis 10 ~ 15 parts, Fructus achilleae 17 ~ 22 parts, Radix Coicis 22 ~ 27 parts, Herba Oxalidis Corniculatae 13 ~ 18 parts, Radix Stephaniae Cepharanthae 8 ~ 13 parts, Citrus aurantium L. var. amara Engl. 12 ~ 17 parts, slightly 25 ~ 30 parts, Radix Glycyrrhizae, Semen Aesculi 14 ~ 19 parts, Semen Citri grandis 10 ~ 15 parts, 18 ~ 23 parts, Rhizoma Bergeniae scopulosae, Fructus Atriplicis Sibiricae 25 ~ 30 parts, Herba Thysanolaenae maximae 23 ~ 28 parts and Juniperus rigida Sieb.et Zucc. 20 ~ 25 parts.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: Herba urariae macrostachyae 13 parts, 16 parts, Radix Ilicis Asprellae rattan, Herba humuli scandentis 13 parts, Fructus achilleae 18 parts, Radix Coicis 26 parts, Herba Oxalidis Corniculatae 15 parts, Radix Stephaniae Cepharanthae 12 parts, Citrus aurantium L. var. amara Engl. 14 parts, slightly 28 parts, Radix Glycyrrhizae, Semen Aesculi 15 parts, Semen Citri grandis 14 parts, 19 parts, Rhizoma Bergeniae scopulosae, Fructus Atriplicis Sibiricae 29 parts, Herba Thysanolaenae maximae 24 parts and Juniperus rigida Sieb.et Zucc. 24 parts.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: Herba urariae macrostachyae 10 parts, 18 parts, Radix Ilicis Asprellae rattan, Herba humuli scandentis 10 parts, Fructus achilleae 21 parts, Radix Coicis 23 parts, Herba Oxalidis Corniculatae 16 parts, Radix Stephaniae Cepharanthae 10 parts, Citrus aurantium L. var. amara Engl. 16 parts, slightly 26 parts, Radix Glycyrrhizae, Semen Aesculi 17 parts, Semen Citri grandis 12 parts, 22 parts, Rhizoma Bergeniae scopulosae, Fructus Atriplicis Sibiricae 26 parts, Herba Thysanolaenae maximae 26 parts and Juniperus rigida Sieb.et Zucc. 22 parts.

Present invention also offers the preparation method of above-mentioned Chinese medicine, when the dosage form of described Chinese medicine is granule, its preparation method comprises the following steps:

Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 4 ~ 8 times, mixture is the ethanol of 85% ~ 95%, be heated to boiling reflux 3 ~ 5 hours, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.04 ~ 1.10, spraying dry, the inlet temperature of spray dryer 160 ~ 175 DEG C, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder,

Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.

Present invention also offers the preparation method of above-mentioned Chinese medicine, when the dosage form of described Chinese medicine is oral solutions, its preparation method comprises the following steps:

The first step, by Herba urariae macrostachyae, Radix Ilicis Asprellae rattan, Herba humuli scandentis, Fructus achilleae, Radix Coicis, Herba Oxalidis Corniculatae, Radix Stephaniae Cepharanthae and Citrus aurantium L. var. amara Engl. mixing, add relative to mixture 3 times ~ 5 times amount determining alcohol be 55% ~ 65% alcohol reflux 2 times ~ 4 times, each 2 hours ~ 3 hours, filter, filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.30 ~ 1.32, for subsequent use;

Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 3 ~ 5 times of water gagings, boils 2 ~ 4 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.27 ~ 1.29;

3rd step, the described mastic mixing that the first step, second step are obtained, 55 DEG C ~ 65 DEG C reduced vacuum dryings, get dry extract powder;

4th step, is added ethanol in the described dried cream powder that the 3rd step is obtained, and obtains containing alcohol mastic, and the described alcohol content containing alcohol mastic is 65% ~ 70%; Carry out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, the chilling treatment time is 30 ~ 40 hours, and refrigerated storage temperature is 2 DEG C ~ 6 DEG C;

5th step, adds cane sugar powder, active carbon by described dealcoholysis mastic, carries out heat treated, filtration treatment, dilution process successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.1 ~ 0.3; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.001 ~ 0.002; The time of described heat treated is 20 ~ 40 minutes, and temperature is 100 DEG C ~ 110 DEG C;

6th step, the more described semi-finished product that the 5th step obtains are carried out filtration treatment, embedding process, sterilization treatment successively, obtain described Chinese medicine oral liquid finished product.

Beneficial effect of the present invention: Chinese medicine provided by the invention, utilizes the theory of Chinese medical science that China is traditional, coordinates the operative treatment of doctor trained in Western medicine, and to treatment primary angle-closure glaucoma determined curative effect, side effect is little; On the basis of operative treatment, well can control postoperative intraocular pressure, control Deterioration of Optic Nerve in Glaucoma, thus better treat glaucoma.

Detailed description of the invention

The invention provides a kind of Chinese medicine for the treatment of primary angle-closure glaucoma, its raw medicinal material comprises: Herba urariae macrostachyae, Radix Ilicis Asprellae rattan, Herba humuli scandentis, Fructus achilleae, Radix Coicis, Herba Oxalidis Corniculatae, Radix Stephaniae Cepharanthae, Citrus aurantium L. var. amara Engl., Radix Glycyrrhizae is slightly, Semen Aesculi, Semen Citri grandis, Rhizoma Bergeniae scopulosae, Fructus Atriplicis Sibiricae, Herba Thysanolaenae maximae and Juniperus rigida Sieb.et Zucc..

In described Chinese medicine, the pharmacology of each raw medicinal material is as follows:

Herba urariae macrostachyae: [another name] mole cricket tail, long fringe leopard cat tail grass, rabbit Canis familiaris L. tail, Mao Gongshu, anti-Cordyceps, cat are climbed the tree, Herba Urariae Lagopodioidis.[source] medical material Ji Yuan: the branch and leaf penetrated for leguminous plant long fringe cat tail.[nature and flavor] are lightly seasoned; Cool in nature.[return through] spleen; Large intestine channel.[function cures mainly] heat clearing away; Hemostasis; Removing food stagnancy; Parasite killing.Main flu; Cough; Malaria; Spit blood; Spitting of blood; Hematuria; Traumatic hemorrhage; Infantile malnutrition; Filaricide.[extracts] " China's book on Chinese herbal medicine "

Radix Ilicis Asprellae rattan: [another name] Herba Anoectochili roxburghii, Radix cycleae hypoglaucae, post Eumeces Chinensis, Radix Sophorae Tonkinensis, Jasminum nervosum Lour, the young rattan of clam, JINSUOSHI, unipods Sapium sebiferum (L.) Roxb..[source] medical material Ji Yuan: be root or the rattan of menispermaceous plants powder vane rings rattan.[nature and flavor] are bitter; Cold.[return through] lung; Large intestine; Liver Channel.[function cures mainly] heat-clearing and toxic substances removing; Wind-expelling pain-stopping; Relieving stranguria by diuresis.Main anemopyretic cold; Cough; Laryngopharynx swelling and pain; Diphtheria; Acute toothache; Intestinal is scorching; Dysentery; Urinary tract infection and lithangiuria; Rheumatalgia; Sore swollen toxin; Venom.[extracts] " China's book on Chinese herbal medicine "

Herba humuli scandentis: [another name] strangles that grass, blackwort symphytum, Pueraria lobota humulus are climing, Ge Leman, come poisonous weeds, Pueraria lobota Herba humuli scandentis, puckery LUOMAN, cut people rattan, Caulis Momordicae Charantiae, Galium spurium L., draw rattan, Herba Ipomoeae Cairicae, great Ye Herba Ipomoeae Cairicae.[source] medical material Ji Yuan: be the herb of moraceae plants Herba humuli scandentis.[nature and flavor] are sweet; Bitter; Cold in nature.[return through] lung; Kidney channel.[function cures mainly] heat-clearing and toxic substances removing; Inducing diuresis for treating stranguria syndrome; .Main cough due to lung-heat; Lung abscess; Deficiency-heat excessive thirst; Pyretic stranguria; Edema; Dysuria; Damp-heat dysentery; Pathopyretic ulcer; Skin pruritus.[extracts] " China's book on Chinese herbal medicine "

Fructus achilleae: [source] medical material Ji Yuan: be the fruit of feverfew high mountain Millefolium.[nature and flavor] sour in the mouth; Bitter; Property is put down.[function cures mainly] QI invigorating; Improving eyesight.Main deficiency of vital energy and physically weak; Blurring of vision.[extracts] " China's book on Chinese herbal medicine "

Radix Coicis: [another name] must carry pearl root.[source] medical material Ji Yuan: be the root welding technology of grass Semen Coicis.[nature and flavor] are sweet; Light; Be slightly cold.[return through] spleen; Urinary bladder channel.[function cures mainly] clearing away heat-damp and promoting diuresis; Treating stranguria hemostasis; Eliminating stagnated food and killing intestinal worms.Main pyretic stranguria; Stranguria with blood; Stranguria marked by chyluria; Metrorrhagia; Leucorrhea; Edema; Jaundice due to damp-heat; Dyspeptic abdominal distention; Ascariasis.[extracts] " China's book on Chinese herbal medicine "

Herba Oxalidis Corniculatae: [another name] sour dustpan, three folic acid grass, acid Herba Linderniae Crustaceae, turtledove acid grass, little sour thatch, passeris montani saturati forest-grass, Calyx seu fructus physalis, red grandson executes, acid is chirped, Marsilea quadrifolia L, Oxalis corniculata Linn., passeris montani saturati grass, acid Herba Linderniae Crustaceae, acid dumpling grass, little sour Seedling, acid grass, three folic acid, triangle acid, passeris montani saturati acid, Strepopelia orientalis grass, tart flavour grass, acid fan fan grass, SANYE Calyx seu fructus physalis, acid acid grass, acid speckle Herba Amaranthi tricoloris, salty acid grass, acid jealous woman grass, sourly must to slip, floor file lotus, dark plum grass, SANYE Hydrocotyle sibthorpioides lam.Var.Batvachium (Hand.-Mazz.) et shan., Hemerocallis citrina Baroni prunus mume (sieb.) sieb.et zucc., Caulis et folium pavettae hongkongensis, Herba Malvastri Coromandeliani, six leaf lotuses, wild Fructus Trichosanthis Cucumeroidis grass, Fructus Trichosanthis Cucumeroidis acid, soaring bubble, long blood grass, acid Ganoderma lucidum seu Japonicum, acid batch son, Dongyang fire weed, Radix Chloranthi Fortunei, langenaria siceria acid, wood pigeon acid, Strepopelia orientalis acid, three prunus mume (sieb.) sieb.et zucc. grass, crow acid.[source] medical material Ji Yuan: be the oxalic herb of Oxalidaceae plant.[nature and flavor] acid; Cold.[return through] large intestine; Small intestine meridian [each discussion] diarrhea due to damp-heat; Dysentery; Jaundice; Stranguria; Leukorrhagia; Spit blood; Epistaxis; Hematuria; Have through uncomfortable; Traumatic injury; Laryngopharynx swelling and pain; Carbuncle furuncle; Erysipelas; Eczema; Scabies; Hemorrhoid; Measles; Burn and scald; Snake bite and insect sting.[extracts] " China's book on Chinese herbal medicine "

Radix Stephaniae Cepharanthae: [another name] BAIYAO, BAIYAO root, Stephania cepharatha Hayata.[source] medical material Ji Yuan: be the tuber of menispermaceous plants Radix Stephaniae Cepharanthae.[nature and flavor] toil; Cool; Mild toxicity.[return through] spleen; Lung; Kidney channel.[function cures mainly] heat-clearing and toxic substances removing; Wind-expelling pain-stopping; Cooling blood for hemostasis.Main laryngopharynx swelling and pain; Pyretic toxicity carbuncle; Rheumatic arthralgia; Stomachache; Dysentery; Spit blood; Epistaxis; Traumatic hemorrhage.[extracts] " China's book on Chinese herbal medicine "

Citrus aurantium L. var. amara Engl.: [another name] Fructus Aurantii flower, Citrus aurantium L. var. amara Engl., Citrus aurantium Linn. flower.[source] medical material Ji Yuan: be the alabastrum of rutaceae Citrus aurantium L. var. amara Engl..[nature and flavor] are pungent; Sweet; Micro-hardship; Property is put down.[function cures mainly] regulates the flow of vital energy the chest stuffiness relieving; Stomach function regulating preventing or arresting vomiting.It is main that painful abdominal mass is vexed in the heart; Abdominal distention; Anorexia; Nausea and vomiting.[extracts] " China's book on Chinese herbal medicine "

Radix Glycyrrhizae is slightly: [source] medical material Ji Yuan: for the last ending of the root of leguminous plant Rhizoma Bergeniae scopulosae is divided or radicula.[nature and flavor] are sweet; Cold.[return through] heart; Liver; Spleen channel.[function cures mainly] eliminating fire and detoxication; Inducing diuresis for treating stranguria syndrome.Main pyretic stranguria; Oliguria; Pain in penis; Accumulated heat in the heart.[extracts] " China's book on Chinese herbal medicine "

Semen Aesculi: [another name] Aesculus, Suo woman, Wu Ji, Xian Li, Fructus Pistaciae Verae, sulu, Suo Luoguo, shuttle spinulose tree fern.[source] medical material Ji Yuan: be the fruits and seeds of Hippocastanaceae plant Aesculus chinensis Bunge, Radix Aesculi or Aesculus.[nature and flavor] sweet in the mouth; Warm in nature.[return through] liver; Stomach warp.[function cures mainly] is soothing the liver; Regulate the flow of vital energy; Alleviating distention in middle-JIAO; Pain relieving.The main breast side of body; Distending pain of the breast; Dysmenorrhea; Gastric abscess.[extracts] " China's book on Chinese herbal medicine "

Semen Citri grandis: [source] medical material Ji Yuan: be the seed of Citrus paradisi Macfadyen.[nature and flavor] are bitter; Flat; Temperature.[return through] Liver Channel.[function cures mainly] depressed liver-energy dispersing and QI regulating; Lung qi dispersing cough-relieving.Main hernia lung cold cough.[extracts] " China's book on Chinese herbal medicine "

Rhizoma Bergeniae scopulosae: [another name] stone Chinese cabbage, Rhizoma Bergeniae scopulosae.[source] medical material Ji Yuan: be the rhizome of saxifragaceae plant Qinling Mountains Rhizoma Seu Herba Bergeniae.[nature and flavor] are puckery; Micro-hardship; Flat.[return through] lung; Spleen; Liver; Urinary bladder channel.[function cures mainly] strengthens the spleen and stomach; The solid intestinal of astringent therapy; Diuretic is invigorated blood circulation.Main acute chronic gastroenteritis; Edema; Metrorrhagia; Leucorrhea; Stranguria; Dysentery; Impetigo; Bald deep blue; Scabies.[extracts] " China's book on Chinese herbal medicine "

Fructus Atriplicis Sibiricae: [another name] Herba chenopodii.[source] medical material Ji Yuan: be the fruit of chenopod atriplex sibirica and Herba Atriplicis centralasiaticae.[nature and flavor] are bitter; Property is put down.[return through] lung; Liver Channel.[function cures mainly] liver heat removing and eyesight improving; Dispelling wind for relieving itching; Promoting blood circulation and detumescence; Lactogenesis.Main conjunctival congestion and swelling pain; Headache; Dizzy; Cough with dyspnea; Sore throat; Rubella; Skin carcinoma is itched; Toxic swelling; Milk is not smooth.[extracts] " China's book on Chinese herbal medicine "

Herba Thysanolaenae maximae: [another name] Folium illicii Lanceolati, Rice dumpling leaf grass, grass of sweeping the floor.The root that [source] is grass Herba Thysanolaenae maximae or Radix Crotalariae szemoensis.[nature and flavor] sweet in the mouth; Cool in nature.[return through] enters lung, gallbladder meridian.[function cures mainly] heat clearing away preventing the attack (or recurrence) of malaria; Relieving cough and asthma.Main malaria; Excessive thirst; Diarrhoea; Cough with asthma.[extracts] " China's book on Chinese herbal medicine "

Juniperus rigida Sieb.et Zucc.: [source] medical material Ji Yuan: be branch and leaf and the cone of Cupressaceae plant Juniperus rigida Sieb.et Zucc..[nature and flavor] are sweet; Bitter; Property is put down.[function cures mainly] dispels the wind; Analgesia; Dehumidifying; Diuresis.Main rheumatic arthritis; Gout; Nephritis; Edema; Urinary tract infection.[extracts] " China's book on Chinese herbal medicine "

In described Chinese medicine, the ratio of weight and number of each raw medicinal material is as follows: Herba urariae macrostachyae 8 ~ 18 parts, 10 ~ 20 parts, Radix Ilicis Asprellae rattan, Herba humuli scandentis 10 ~ 20 parts, Fructus achilleae 15 ~ 25 parts, Radix Coicis 20 ~ 30 parts, Herba Oxalidis Corniculatae 10 ~ 20 parts, Radix Stephaniae Cepharanthae 5 ~ 15 parts, Citrus aurantium L. var. amara Engl. 10 ~ 20 parts, slightly 20 ~ 30 parts, Radix Glycyrrhizae, Semen Aesculi 10 ~ 20 parts, Semen Citri grandis 10 ~ 20 parts, 15 ~ 25 parts, Rhizoma Bergeniae scopulosae, Fructus Atriplicis Sibiricae 20 ~ 30 parts, Herba Thysanolaenae maximae 20 ~ 30 parts and Juniperus rigida Sieb.et Zucc. 20 ~ 30 parts.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material is as follows: Herba urariae macrostachyae 9 ~ 14 parts, 15 ~ 20 parts, Radix Ilicis Asprellae rattan, Herba humuli scandentis 10 ~ 15 parts, Fructus achilleae 17 ~ 22 parts, Radix Coicis 22 ~ 27 parts, Herba Oxalidis Corniculatae 13 ~ 18 parts, Radix Stephaniae Cepharanthae 8 ~ 13 parts, Citrus aurantium L. var. amara Engl. 12 ~ 17 parts, slightly 25 ~ 30 parts, Radix Glycyrrhizae, Semen Aesculi 14 ~ 19 parts, Semen Citri grandis 10 ~ 15 parts, 18 ~ 23 parts, Rhizoma Bergeniae scopulosae, Fructus Atriplicis Sibiricae 25 ~ 30 parts, Herba Thysanolaenae maximae 23 ~ 28 parts and Juniperus rigida Sieb.et Zucc. 20 ~ 25 parts.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: Herba urariae macrostachyae 13 parts, 16 parts, Radix Ilicis Asprellae rattan, Herba humuli scandentis 13 parts, Fructus achilleae 18 parts, Radix Coicis 26 parts, Herba Oxalidis Corniculatae 15 parts, Radix Stephaniae Cepharanthae 12 parts, Citrus aurantium L. var. amara Engl. 14 parts, slightly 28 parts, Radix Glycyrrhizae, Semen Aesculi 15 parts, Semen Citri grandis 14 parts, 19 parts, Rhizoma Bergeniae scopulosae, Fructus Atriplicis Sibiricae 29 parts, Herba Thysanolaenae maximae 24 parts and Juniperus rigida Sieb.et Zucc. 24 parts.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: Herba urariae macrostachyae 10 parts, 18 parts, Radix Ilicis Asprellae rattan, Herba humuli scandentis 10 parts, Fructus achilleae 21 parts, Radix Coicis 23 parts, Herba Oxalidis Corniculatae 16 parts, Radix Stephaniae Cepharanthae 10 parts, Citrus aurantium L. var. amara Engl. 16 parts, slightly 26 parts, Radix Glycyrrhizae, Semen Aesculi 17 parts, Semen Citri grandis 12 parts, 22 parts, Rhizoma Bergeniae scopulosae, Fructus Atriplicis Sibiricae 26 parts, Herba Thysanolaenae maximae 26 parts and Juniperus rigida Sieb.et Zucc. 22 parts.

Present invention also offers the preparation method of above-mentioned Chinese medicine, when the dosage form of described Chinese medicine is granule, its preparation method comprises the following steps:

Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 4 ~ 8 times, mixture is the ethanol of 85% ~ 95%, be heated to boiling reflux 3 ~ 5 hours, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.04 ~ 1.10, spraying dry, the inlet temperature of spray dryer 160 ~ 175 DEG C, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder,

Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.

Present invention also offers the preparation method of above-mentioned Chinese medicine, when the dosage form of described Chinese medicine is oral solutions, its preparation method comprises the following steps:

The first step, by Herba urariae macrostachyae, Radix Ilicis Asprellae rattan, Herba humuli scandentis, Fructus achilleae, Radix Coicis, Herba Oxalidis Corniculatae, Radix Stephaniae Cepharanthae and Citrus aurantium L. var. amara Engl. mixing, add relative to mixture 3 times ~ 5 times amount determining alcohol be 55% ~ 65% alcohol reflux 2 times ~ 4 times, each 2 hours ~ 3 hours, filter, filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.30 ~ 1.32, for subsequent use;

Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 3 ~ 5 times of water gagings, boils 2 ~ 4 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.27 ~ 1.29;

3rd step, the described mastic mixing that the first step, second step are obtained, 55 DEG C ~ 65 DEG C reduced vacuum dryings, get dry extract powder;

4th step, is added ethanol in the described dried cream powder that the 3rd step is obtained, and obtains containing alcohol mastic, and the described alcohol content containing alcohol mastic is 65% ~ 70%; Carry out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, the chilling treatment time is 30 ~ 40 hours, and refrigerated storage temperature is 2 DEG C ~ 6 DEG C;

5th step, adds cane sugar powder, active carbon by described dealcoholysis mastic, carries out heat treated, filtration treatment, dilution process successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.1 ~ 0.3; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.001 ~ 0.002; The time of described heat treated is 20 ~ 40 minutes, and temperature is 100 DEG C ~ 110 DEG C;

6th step, the more described semi-finished product that the 5th step obtains are carried out filtration treatment, embedding process, sterilization treatment successively, obtain described Chinese medicine oral liquid finished product.

Below adopt example to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.

Embodiment 1: granule

Get Herba urariae macrostachyae 100g, Radix Ilicis Asprellae rattan 180g, Herba humuli scandentis 100g, Fructus achilleae 210g, Radix Coicis 230g, Herba Oxalidis Corniculatae 160g, Radix Stephaniae Cepharanthae 100g, Citrus aurantium L. var. amara Engl. 160g, Radix Glycyrrhizae is 260g slightly, Semen Aesculi 170g, Semen Citri grandis 120g, Rhizoma Bergeniae scopulosae 220g, Fructus Atriplicis Sibiricae 260g, Herba Thysanolaenae maximae 260g and Juniperus rigida Sieb.et Zucc. 220g;

Its preparation method comprises the following steps:

Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 6 times, mixture is the ethanol of 95%, be heated to boiling reflux 3 hours, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 2ml per minute slowly percolation, collect percolate, when being evaporated to 55 DEG C subsequently under vacuum 0.08Mpa, relative density is the mastic of 1.07, spraying dry, the inlet temperature 170 DEG C of spray dryer, leaving air temp 80 DEG C, be ground into powder subsequently, make dried cream powder;

Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 times and 0.1 times in the dried cream powder obtained, makes granule, in 50 DEG C of dryings, obtains granule.

Embodiment 2: oral solutions

Get Herba urariae macrostachyae 130g, Radix Ilicis Asprellae rattan 160g, Herba humuli scandentis 130g, Fructus achilleae 180g, Radix Coicis 260g, Herba Oxalidis Corniculatae 150g, Radix Stephaniae Cepharanthae 120g, Citrus aurantium L. var. amara Engl. 140g, Radix Glycyrrhizae is 280g slightly, Semen Aesculi 150g, Semen Citri grandis 140g, Rhizoma Bergeniae scopulosae 190g, Fructus Atriplicis Sibiricae 290g, Herba Thysanolaenae maximae 240g and Juniperus rigida Sieb.et Zucc. 240g;

Its preparation method comprises the following steps:

The first step, by Herba urariae macrostachyae, Radix Ilicis Asprellae rattan, Herba humuli scandentis, Fructus achilleae, Radix Coicis, Herba Oxalidis Corniculatae, Radix Stephaniae Cepharanthae and Citrus aurantium L. var. amara Engl. mixing, add relative to mixture 5 times amount determining alcohol be 65% alcohol reflux 4 times, each 3 hours, filter, filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.31, for subsequent use;

Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 3 times of water gagings, boils 2 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.28;

3rd step, the described mastic mixing that the first step, second step are obtained, 65 DEG C of reduced vacuum dryings, get dry extract powder;

4th step, is added ethanol in the described dried cream powder that the 3rd step is obtained, and obtains containing alcohol mastic, and the described alcohol content containing alcohol mastic is 70%; Carry out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, the chilling treatment time is 35 hours, and refrigerated storage temperature is 4 DEG C;

5th step, adds cane sugar powder, active carbon by described dealcoholysis mastic, carries out heat treated, filtration treatment, dilution process successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.2; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.001; The time of described heat treated is 30 minutes, and temperature is 100 DEG C;

6th step, the more described semi-finished product that the 5th step obtains are carried out filtration treatment, embedding process, sterilization treatment successively, obtain described Chinese medicine oral liquid finished product.

Toxicity test:

Acute toxicity testing: application mice 50, male and female half and half, body weight 16 ~ 22g, carries out acute toxicity test.Mice is divided into two groups at random, i.e. matched group and administration group, before experiment, fasting 12 hours, is dissolved in water by granule prepared by embodiments of the invention 1, (concentration is 5.26g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg (namely unit dosage form is 26.3 crude drugs/kg), and matched group gives normal saline, administration in one day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage granule LD50>26.3 crude drug/kg of the present invention, every day, maximum dosage-feeding was 52.6 crude drugs/day.Chinese medicine clinical application amount of the present invention be 2.6g crude drug/day/people, adult body weight in 60KG, average dosage is 0.043g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 19g) oral administration gavage Chinese medicine of the present invention is 1065 times of quantity.Therefore Chinese medicine acute toxicity of the present invention is low, clinical drug safety.

Long term toxicity test: the granule of the embodiment of the present invention 1 presses 12.33,20.12 and 38.60g crude drug/kg continuous use 16 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 6 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine of the present invention to rat all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 16 weeks and drug withdrawal are after 6 weeks, and each internal organs of rat are all without obviously changing.Illustrate that Chinese medicine of the present invention is little to toxicity after rat long-term prescription, also there is no difference reaction after drug withdrawal, application safety.

Clinical experiment:

Clinical data: 90 examples (suffering from eye for 118) patient is my Out-patient Department and inpatient, is divided into treatment group and matched group at random.Treatment group 45 example (suffering from eye for 57), male 29 example, women 16 example; 46 ~ 72 years old age; Acute angle closure glaucoma 39 suffers from eye, and chronic angle closure glaucoma 18 suffers from eye; Vision before treatment: <0.1 person 12 suffers from eye, suffers from eye for 0.1 ~ 0.3 25, and suffer from eye for 0.4 ~ 0.6 13, >0.6 person 7 suffers from eye; Visual field Random early Detection 17 suffers from eye, and progressive stage is damaged 28 and suffers from eye, and late lesion 12 suffers from eye; Intraocular pressure distribution before treatment: <30mmHg person 13 suffers from eye, and 30 ~ 40mmHg person 20 suffers from eye, and 40 ~ 50mmHg person 16 suffers from eye, and >50mmHg person 8 suffers from eye; The preoperative intraocular pressure for the treatment of group is 3.25kPa ~ 8.73kPa, average 6.03kPa.Matched group 45 example (suffering from eye for 61), male 26 example, women 19 example; 45 ~ 71 years old age; Acute angle closure glaucoma 42 suffers from eye, and chronic angle closure glaucoma 19 suffers from eye; Vision before treatment: <0.1 person 11 suffers from eye, suffers from eye for 0.1 ~ 0.3 28, and suffer from eye for 0.4 ~ 0.6 14, >0.6 person 8 suffers from eye; Visual field Random early Detection 16 suffers from eye, and progressive stage is damaged 34 and suffers from eye, and late lesion 11 suffers from eye; Intraocular pressure distribution before treatment: <30mmHg person 14 suffers from eye, and 30 ~ 40mmHg person 22 suffers from eye, and 40 ~ 50mmHg person 16 suffers from eye, and >50mmHg person 9 suffers from eye; The preoperative intraocular pressure of matched group is 3.31kPa ~ 8.84kPa, average 6.15kPa.Two groups of patients are through statistical analysis in sex, age, clinical symptoms etc., and there was no significant difference (P>0.05), has comparability.

Diagnostic criteria: diagnostic criteria and Zeng Qinghua chief editor " ophthalmology of Chinese medicine " TCM syndrome diagnostic criteria of editing " clinical glaucoma " primary angle-closure glaucoma with reference to Zhou Wenbing.

Exclusion standard: the secondary glaucoma caused by a variety of causes; Be associated with severe corneal, iris pathological changes person; Anti-glaucoma surgery generation severe complication, as ciliary block glaucoma, anterior chamber's massive hemorrhage, postoperative anterior cham ber intraocularlenses etc.; Gestation and women breast-feeding their children; Be associated with severe primary disease and the psychotics such as liver, kidney, hemopoietic system, hormonal system; The patient do not taken medicine on time on request; The patient followed up a case by regular visits to can not be carried out on request.

Therapeutic Method:

Treatment group: after preoperative intraocular pressure controls, implements traditional trabeculectomy.The postoperative granule taken the embodiment of the present invention 1 and prepare, every day 3 times, each 20g; Postoperative one month.

Matched group: after preoperative intraocular pressure controls, implements traditional trabeculectomy.Postoperatively take ATP20mg, every day 3 times; VB11 0mg, every day 3 times; Methycobal 500 μ g, every day 3 times; Postoperative one month.

Traditional trabeculectomy: times promise happiness topical anesthesia, lignocaine ball week and Subconjunctival anesthesia, superior rectus traction sutures, doing with fornix is the conjunctival flap of substrate, conjunctival flap deflection nasal side or temporo side, the sclera exposed burns hemostasis, take limbus of corneae as the rectangle scleral flap that 5mm × 4mm1/2 thickness is done in substrate, before be separated to 1mm in limpid cornea district, the trabecular tissue of excision below scleral valve 1.5mm × 2mm, and do the iris periphery excision of corresponding site, reduction scleral flap, 10/0 nylon line suture scleral flap top two pin, and respectively sew up a pin in the corneosclera place, two ends of bulbar conjunctiva otch, below sub-conjunctival injection tobramycin 20,000 U, dexamethasone 2.5mg, be coated with 10g/L atropine eye ointment.

Observation item: record preoperative and postoperative vision weekly, intraocular pressure, the visual field and folliculus change respectively.

Curative effect determinate standard: effective: vision improves more than 2 row; The visual field expands more than 5 °; Intraocular pressure is within 2.8kPa.Take a turn for the better: vision improves 2 row, and the visual field expands more than 2 °, and intraocular pressure is within 2.8kPa.Stable: the vision visual field is unchanged, and intraocular pressure is within 2.8kPa.Invalid: visual deterioration, constriction of visual field, intraocular pressure is at more than 2.8kPa.

Therapeutic outcome:

(1) month after operation two groups of eyesight improving situations compare, and the results are shown in Table 1.

Table 1 month after operation two groups of eyesight improving situations are compared as follows:

Group	Eye number	Effective	Take a turn for the better	Stable	Invalid	Total effective rate (%)
							Matched group	61	12	16	22	11	50(81.97％)
Treatment group	57	27	18	9	3	54(94.74％)

Known by table 1, compare with matched group, treatment group can significantly improve the ratio of effective patient and improvement patient, and total effective rate is higher simultaneously.

(2) preoperatively improve situation with month after operation two groups of patient's intraocular pressures and compare, the results are shown in Table 2.

Be compared as follows with postoperative average intraocular pressure before table 2 liang group operation in patients:

Group	Eye number	Preoperative average intraocular pressure	Postoperative average intraocular pressure
				Matched group	61	6.15kPa	2.43kPa
Treatment group	57	6.03kPa	1.64kPa

Known by table 2, relative and matched group, treatment group better can reduce the intraocular pressure of glaucoma patient.

(3) formational situation of month after operation two groups of patient's filtration blebs compares, in table 3.

The postoperative two groups of patient's functional type avascular filtering bleb formational situations of table 3 are compared as follows:

Group	Eye number	Filtration bleb	Non-functional avascular filtering bleb	Formation rate
					Matched group	61	51	10	83.6％
Treatment group	57	50	7	87.7％

Model case: Zhang, man, 56 years old, blurred vision was more than 2 years, repeatedly change presbyopic glasses still not see, later stage occurs dizzy, is admitted to hospital and sees a doctor, look into Binocular vison nipple temporo side, optical fundus pale, C/D>0.7, survey 5.04kPa, left side 3.86kPa on the right side of intraocular pressure, the visual field is the tubular visual field, is diagnosed as: eyes former chronic angle-closure's green light.After preoperative intraocular pressure controls, implement traditional trabeculectomy.The postoperative granule taken the embodiment of the present invention 1 and prepare, every day 3 times, each 20g; Medication 20 days, the symptom such as blurred vision and giddy major part alleviates, and after taking 30 days, patient's vision improves 3 row, and the visual field expands 8 °, left eye intraocular pressure 1.69kpa, and right eye intraocular pressure 2.76kpa, follows up a case by regular visits to and do not recur half a year.

The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

Claims (9)

1. treat a Chinese medicine for primary angle-closure glaucoma, it is characterized in that, described Chinese medicine comprises following raw medicinal material: Herba urariae macrostachyae, Radix Ilicis Asprellae rattan, Herba humuli scandentis, Fructus achilleae, Radix Coicis, Herba Oxalidis Corniculatae, Radix Stephaniae Cepharanthae, Citrus aurantium L. var. amara Engl., Radix Glycyrrhizae is slightly, Semen Aesculi, Semen Citri grandis, Rhizoma Bergeniae scopulosae, Fructus Atriplicis Sibiricae, Herba Thysanolaenae maximae and Juniperus rigida Sieb.et Zucc..

2. Chinese medicine as claimed in claim 1, it is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is as follows: Herba urariae macrostachyae 8 ~ 18 parts, 10 ~ 20 parts, Radix Ilicis Asprellae rattan, Herba humuli scandentis 10 ~ 20 parts, Fructus achilleae 15 ~ 25 parts, Radix Coicis 20 ~ 30 parts, Herba Oxalidis Corniculatae 10 ~ 20 parts, Radix Stephaniae Cepharanthae 5 ~ 15 parts, Citrus aurantium L. var. amara Engl. 10 ~ 20 parts, slightly 20 ~ 30 parts, Radix Glycyrrhizae, Semen Aesculi 10 ~ 20 parts, Semen Citri grandis 10 ~ 20 parts, 15 ~ 25 parts, Rhizoma Bergeniae scopulosae, Fructus Atriplicis Sibiricae 20 ~ 30 parts, Herba Thysanolaenae maximae 20 ~ 30 parts and Juniperus rigida Sieb.et Zucc. 20 ~ 30 parts.

3. Chinese medicine as claimed in claim 1 or 2, it is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is as follows: Herba urariae macrostachyae 9 ~ 14 parts, 15 ~ 20 parts, Radix Ilicis Asprellae rattan, Herba humuli scandentis 10 ~ 15 parts, Fructus achilleae 17 ~ 22 parts, Radix Coicis 22 ~ 27 parts, Herba Oxalidis Corniculatae 13 ~ 18 parts, Radix Stephaniae Cepharanthae 8 ~ 13 parts, Citrus aurantium L. var. amara Engl. 12 ~ 17 parts, slightly 25 ~ 30 parts, Radix Glycyrrhizae, Semen Aesculi 14 ~ 19 parts, Semen Citri grandis 10 ~ 15 parts, 18 ~ 23 parts, Rhizoma Bergeniae scopulosae, Fructus Atriplicis Sibiricae 25 ~ 30 parts, Herba Thysanolaenae maximae 23 ~ 28 parts and Juniperus rigida Sieb.et Zucc. 20 ~ 25 parts.

4. the Chinese medicine as described in claims 1 to 3, is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is as follows: Herba urariae macrostachyae 13 parts, 16 parts, Radix Ilicis Asprellae rattan, Herba humuli scandentis 13 parts, Fructus achilleae 18 parts, Radix Coicis 26 parts, Herba Oxalidis Corniculatae 15 parts, Radix Stephaniae Cepharanthae 12 parts, Citrus aurantium L. var. amara Engl. 14 parts, slightly 28 parts, Radix Glycyrrhizae, Semen Aesculi 15 parts, Semen Citri grandis 14 parts, 19 parts, Rhizoma Bergeniae scopulosae, Fructus Atriplicis Sibiricae 29 parts, Herba Thysanolaenae maximae 24 parts and Juniperus rigida Sieb.et Zucc. 24 parts.

5. the Chinese medicine as described in Claims 1-4, is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is as follows: Herba urariae macrostachyae 10 parts, 18 parts, Radix Ilicis Asprellae rattan, Herba humuli scandentis 10 parts, Fructus achilleae 21 parts, Radix Coicis 23 parts, Herba Oxalidis Corniculatae 16 parts, Radix Stephaniae Cepharanthae 10 parts, Citrus aurantium L. var. amara Engl. 16 parts, slightly 26 parts, Radix Glycyrrhizae, Semen Aesculi 17 parts, Semen Citri grandis 12 parts, 22 parts, Rhizoma Bergeniae scopulosae, Fructus Atriplicis Sibiricae 26 parts, Herba Thysanolaenae maximae 26 parts and Juniperus rigida Sieb.et Zucc. 22 parts.

6. the Chinese medicine as described in claim 1 to 5, is characterized in that, when the dosage form of described Chinese medicine is granule, its preparation method comprises the following steps:

Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 4 ~ 8 times, mixture is the ethanol of 85% ~ 95%, be heated to boiling reflux 3 ~ 5 hours, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.04 ~ 1.10, spraying dry, the inlet temperature of spray dryer 160 ~ 175 DEG C, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder,

Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.

7. the Chinese medicine as described in claim 1 to 5, is characterized in that, when the dosage form of described Chinese medicine is oral solutions, its preparation method comprises the following steps:

The first step, by Herba urariae macrostachyae, Radix Ilicis Asprellae rattan, Herba humuli scandentis, Fructus achilleae, Radix Coicis, Herba Oxalidis Corniculatae, Radix Stephaniae Cepharanthae and Citrus aurantium L. var. amara Engl. mixing, add relative to mixture 3 times ~ 5 times amount determining alcohol be 55% ~ 65% alcohol reflux 2 times ~ 4 times, each 2 hours ~ 3 hours, filter, filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.30 ~ 1.32, for subsequent use;

Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 3 ~ 5 times of water gagings, boils 2 ~ 4 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.27 ~ 1.29;

3rd step, the described mastic mixing that the first step, second step are obtained, 55 DEG C ~ 65 DEG C reduced vacuum dryings, get dry extract powder;

4th step, is added ethanol in the described dried cream powder that the 3rd step is obtained, and obtains containing alcohol mastic, and the described alcohol content containing alcohol mastic is 65% ~ 70%; Carry out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, the chilling treatment time is 30 ~ 40 hours, and refrigerated storage temperature is 2 DEG C ~ 6 DEG C;

5th step, adds cane sugar powder, active carbon by described dealcoholysis mastic, carries out heat treated, filtration treatment, dilution process successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.1 ~ 0.3; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.001 ~ 0.002; The time of described heat treated is 20 ~ 40 minutes, and temperature is 100 DEG C ~ 110 DEG C;

6th step, the more described semi-finished product that the 5th step obtains are carried out filtration treatment, embedding process, sterilization treatment successively, obtain described Chinese medicine oral liquid finished product.

8. the preparation method of Chinese medicine described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is granule, and its preparation method comprises the following steps:

Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 4 ~ 8 times, mixture is the ethanol of 85% ~ 95%, be heated to boiling reflux 3 ~ 5 hours, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.04 ~ 1.10, spraying dry, the inlet temperature of spray dryer 160 ~ 175 DEG C, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder,

Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.

9. the preparation method of Chinese medicine described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is oral solutions, and its preparation method comprises the following steps:

The first step, by Herba urariae macrostachyae, Radix Ilicis Asprellae rattan, Herba humuli scandentis, Fructus achilleae, Radix Coicis, Herba Oxalidis Corniculatae, Radix Stephaniae Cepharanthae and Citrus aurantium L. var. amara Engl. mixing, add relative to mixture 3 times ~ 5 times amount determining alcohol be 55% ~ 65% alcohol reflux 2 times ~ 4 times, each 2 hours ~ 3 hours, filter, filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.30 ~ 1.32, for subsequent use;

Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 3 ~ 5 times of water gagings, boils 2 ~ 4 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.27 ~ 1.29;

3rd step, the described mastic mixing that the first step, second step are obtained, 55 DEG C ~ 65 DEG C reduced vacuum dryings, get dry extract powder;

4th step, is added ethanol in the described dried cream powder that the 3rd step is obtained, and obtains containing alcohol mastic, and the described alcohol content containing alcohol mastic is 65% ~ 70%; Carry out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, the chilling treatment time is 30 ~ 40 hours, and refrigerated storage temperature is 2 DEG C ~ 6 DEG C;

5th step, adds cane sugar powder, active carbon by described dealcoholysis mastic, carries out heat treated, filtration treatment, dilution process successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.1 ~ 0.3; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.001 ~ 0.002; The time of described heat treated is 20 ~ 40 minutes, and temperature is 100 DEG C ~ 110 DEG C;

6th step, the more described semi-finished product that the 5th step obtains are carried out filtration treatment, embedding process, sterilization treatment successively, obtain described Chinese medicine oral liquid finished product.