CN106491730A - A kind of treat Chinese medicine composition of glaucoma and preparation method thereof - Google Patents

A kind of treat Chinese medicine composition of glaucoma and preparation method thereof Download PDF

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CN106491730A
CN106491730A CN201710002663.0A CN201710002663A CN106491730A CN 106491730 A CN106491730 A CN 106491730A CN 201710002663 A CN201710002663 A CN 201710002663A CN 106491730 A CN106491730 A CN 106491730A
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semen
glaucoma
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medicine composition
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武海军
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Abstract

Present invention offer is a kind of to treat Chinese medicine composition of glaucoma and preparation method thereof, and the Chinese medicine composition is made up of the raw material of following weight portion:5 10 parts of Folium Ginkgo, 5 10 parts of Cladonia alpestris (L.) Rabenh., 5 10 parts of Semen Plantaginiss, 10 15 parts of the Radix Paeoniae Alba, 7 12 parts of Herba Senecionis Scandentiss, 10 15 parts of Radix et Caulis Opuntiae Dillenii, 10 15 parts of Spica Prunellae, 25 parts of Blumeae preparatum Tabellae, 7 12 parts of Semen Euryaless, 36 parts of Semen Pharbitidiss, 7 12 parts of Fructus Ligustri Lucidi, 10 15 parts of Flos Buddlejae.The present invention can not only reduce intraocular pressure, moreover it is possible to promote the microcirculation of circumference of eyes, protect optic nerve, improve antioxidant ability of organism, have good curative effect to glaucoma, have no side effect safely, and effective percentage has good popularizing value up to 97%.

Description

A kind of treat Chinese medicine composition of glaucoma and preparation method thereof
Technical field
The present invention relates to technical field of Chinese medicines, and in particular to a kind of Chinese medicine composition for treating glaucoma and its preparation side Method.
Background technology
Glaucoma refer to as intraocular pressure increases and cause regarding nipple infringement and a kind of oculopathy of visual disorder, normal eyes 10-21mmHg is pressed in, is pathological phenomenon more than 24mmHg.As pathologic intraocular pressure has exceeded the tolerant degree of optic nerve institute, Cause optic atrophy, cause the loss of the apoptosis and optic nerve fiber of pattern of retinal ganglion cells (RGC) irreversibility, so as to cause Visual function damage, defect of visual field may cause blind at any time.Glaucoma morbidity is rapid, and hazardness is big, is blinding main at present One of property oculopathy, World Health Organization (WHO) has been classified as second diseases causing blindness.
Treatment of the modern medical service technology to glaucoma, how using therapeutic method of surgery, cuts art, trabecular resection in such as iris week Art, valve implanation, goniotomy, room angle exclusion, cyclocryoapplication, diathermanous and Light utilization etc..But Costly, there is higher requirement to the condition that performs the operation, the especially technical merit of doctor.In addition operative treatment is merely resting on In treatment to " disease ", do not have to solve the problems, such as " because ", thoroughly change eye microcirculation, therefore still suffer from recur can Energy.In addition to operative therapy, the medicines such as choline, pantothenic acid, rutacultin, vitamin B complex, vitamin C, vitamin E are also supplemented Therapeutic Method.These drug treatments have certain clinical effectiveness, but are usually unable to thoroughly cure symptoms of glaucoma, and And the application of some Western medicine is easily caused to damage to heart, Liver and kidney, large side effects, long-term taking are very big to body harm.Motherland Medical science thinks that glaucoma belongs to pupil god's disease, and when ancient times fall ill according to which, in pupil god, the change pictograph of color is described as " in glaucoma Barrier ", " absolute glaucoma with cataract ", " bluish glaucoma ", " black glaucoma ", " glaucoma ", are listed within " five kinds of glaucoma " category, or with normal Witness awaits your instructions entitled " mydriasis ", or is listed in the categories such as " thunder-headache ", " migraine ", its basic pathogenesis be by wind, fire, expectorant, Strongly fragrant and imbalance of YIN and YANG, causes qi-blood disharmony, and passages through which vital energy circulates is unfavorable, and sweat pore obstruction in mesh, caused by stagnation of QI-blood and body fluid in eyeball.Inventor's root According to clinical practice for many years, it is proposed that technical scheme, for glaucoma has good therapeutic effect.
Content of the invention
For the deficiencies in the prior art, the invention provides a kind of Chinese medicine composition for treating glaucoma and its preparation side Method.
For realizing that object above, the present invention are achieved by the following technical programs:
A kind of Chinese medicine composition for treating glaucoma, is made up of the raw material of following weight portion:Folium Ginkgo 5-10 parts, Cladonia alpestris (L.) Rabenh. 5-10 parts, Semen Plantaginiss 5-10 parts, Radix Paeoniae Alba 10-15 parts, Herba Senecionis Scandentiss 7-12 parts, Radix et Caulis Opuntiae Dillenii 10-15 parts, Spica Prunellae 10-15 parts, Blumeae preparatum Tabellae 2-5 parts, Semen Euryaless 7-12 parts, Semen Pharbitidiss 3-6 parts, Fructus Ligustri Lucidi 7-12 parts, Flos Buddlejae 10-15 parts.
Preferably, it is made up of the raw material of following weight portion:8 parts of Folium Ginkgo, 7 parts of Cladonia alpestris (L.) Rabenh., 8 parts of Semen Plantaginiss, 11 parts of the Radix Paeoniae Alba, 10 parts of Herba Senecionis Scandentiss, 12 parts of Radix et Caulis Opuntiae Dillenii, 11 parts of Spica Prunellae, 4 parts of Blumeae preparatum Tabellae, 10 parts of Semen Euryaless, 5 parts of Semen Pharbitidiss, 10 parts of Fructus Ligustri Lucidi, Flos Buddlejae 12 parts.
Preferably, it is made up of the raw material of following weight portion:7 parts of Folium Ginkgo, 8 parts of Cladonia alpestris (L.) Rabenh., 8 parts of Semen Plantaginiss, 13 parts of the Radix Paeoniae Alba, 11 parts of Herba Senecionis Scandentiss, 13 parts of Radix et Caulis Opuntiae Dillenii, 12 parts of Spica Prunellae, 4 parts of Blumeae preparatum Tabellae, 10 parts of Semen Euryaless, 4 parts of Semen Pharbitidiss, 9 parts of Fructus Ligustri Lucidi, Flos Buddlejae 14 parts.
The preparation method of the Chinese medicine composition for the treatment of glaucoma, step are as follows:
1) Folium Ginkgo, the Radix Paeoniae Alba and Radix et Caulis Opuntiae Dillenii are crushed, adds and be pre-heated in 110-120 DEG C of heating furnace, rolling heating 30-40s, obtains material I;
2) Blumeae preparatum Tabellae is ground crushing, obtains material II;
3) by Cladonia alpestris (L.) Rabenh., Semen Plantaginiss, Herba Senecionis Scandentiss, Spica Prunellae, Semen Euryaless, Semen Pharbitidiss, Fructus Ligustri Lucidi, Flos Buddlejae mixing, 8- is added The water of 10 times of quality, decocts after extracting 1h, is added thereto to step 1) the uncooled material I of fresh baked, continues to decoct 1-2h, mistake Filter, obtains filtrate;
4) filtrate is carried out concentrating under reduced pressure, obtains the clear paste that relative density is 1.05 (60 DEG C), be added thereto to material II, stir Mix uniformly, obtain mixed liquor;
5) pharmaceutically acceptable carrier is added in mixed liquor, be prepared into corresponding pharmaceutical dosage form.
Preferably, the dosage form is tablet, granule, decoction, capsule or pill.
In the present invention, effect of each raw material is as follows:
Folium Ginkgo:Mild-natured, sweet in the mouth, hardship, puckery, thoughts of returning home warp, lung meridian, have functions that astringing the lung, relieving asthma, blood circulation promoting and blood stasis dispelling, pain relieving.
Cladonia alpestris (L.) Rabenh.:Mild-natured, lightly seasoned, Return liver, stomach, have functions that suppressing the hyperactive liver and easing the stomach, regulating menstruation, hemostasis.
Semen Plantaginiss:Cold nature, sweet in the mouth return kidney, liver, lung, small intestine meridian, with clearing away heat and promoting diuresis, eliminating dampness by diuresis is treating stranguria, improving eyesight, eliminating the phlegm Effect.
The Radix Paeoniae Alba:Cold nature, bitter in the mouth, acid, Return liver, spleen channel, have functions that smooth liver and relieve pain, nourishing blood for regulating menstruation, astringing YIN to stop sweating.
Herba Senecionis Scandentiss:Cold in nature, bitter in the mouth, Return liver, lung meridian, with heat-clearing and toxic substances removing, cool blood detumescence, liver heat removing and eyesight improving, parasite killing pain relieving it Effect.
Radix et Caulis Opuntiae Dillenii:Cold in nature, bitter in the mouth returns stomach, have functions that promoting flow of QI and blood, cooling blood for hemostasis, removing toxic substances and promoting subsidence of swelling.
Spica Prunellae:Cold in nature, acrid in the mouth, hardship, return liver warp, gallbladder meridian, have functions that relieving inflammation or internal heat, improving eyesight, eliminating stagnation, detumescence, with controlling mesh Red swell and ache, mesh pearl nyctalgia, dizziness of having a headache, scrofula, goiter, acute mastitis swell and ache, thyromegaly, tuberculous lymphadenitiss, cyclomastopathy, height Blood pressure.
Blumeae preparatum Tabellae:Cold in nature, bitter in the mouth, pungent, puckery, have functions that heat clearing away, detumescence, pain relieving.
Semen Euryaless:Mild-natured, sweet in the mouth is puckery, returns spleen, kidney channel, have functions that invigorating the spleen and replenishing QI, supplementing the kidney to control the nocturnal, eliminating dampness and arresting leucorrhea.
Semen Pharbitidiss:Cold in nature, bitter in the mouth, return lung, kidney, large intestine channel are washed drink, parasite killing with removing water retention by purgation relieving constipation, expectorant and attack long-pending effect.
Fructus Ligustri Lucidi:Cool in nature, sweet in the mouth, hardship return liver and kidney channel, have functions that nourishing the liver and kidney, improving eyesight black hair.
Flos Buddlejae:Cold nature, sweet in the mouth, return liver warp, have functions that heat clearing away nourishing the liver, pathogenic fire purging, improving acuity of vision and removing nebula.
Beneficial effect of the present invention:The mutual compatibility of each medicine in the present invention, based on liver and kidney tonifying, helps with heat clearing away, pathogenic fire purging, work Blood, liver heat removing, can not only reduce intraocular pressure, moreover it is possible to promote the microcirculation of circumference of eyes, protect optic nerve, improve body antioxidation energy Power, has good curative effect, has no side effect safely to glaucoma, and effective percentage has good popularizing value up to 97%.
Specific embodiment
Purpose, technical scheme and advantage for making the embodiment of the present invention is clearer, below in conjunction with the embodiment of the present invention, Technical scheme in the embodiment of the present invention is clearly and completely described, it is clear that described embodiment is the present invention one Divide embodiment, rather than whole embodiments.Embodiment in based on the present invention, those of ordinary skill in the art are not being made The every other embodiment obtained under the premise of creative work, belongs to the scope of protection of the invention.
Embodiment 1:
A kind of Chinese medicine composition for treating glaucoma, is made up of the raw material of following weight portion:8 parts of Folium Ginkgo, Cladonia alpestris (L.) Rabenh. 7 Part, 8 parts of Semen Plantaginiss, 11 parts of the Radix Paeoniae Alba, 10 parts of Herba Senecionis Scandentiss, 12 parts of Radix et Caulis Opuntiae Dillenii, 11 parts of Spica Prunellae, 4 parts of Blumeae preparatum Tabellae, 10 parts of Semen Euryaless, lead a cow 5 parts of son, 10 parts of Fructus Ligustri Lucidi, 12 parts of Flos Buddlejae.
The preparation method of the Chinese medicine composition for the treatment of glaucoma, step are as follows:
1) Folium Ginkgo, the Radix Paeoniae Alba and Radix et Caulis Opuntiae Dillenii are crushed, adds and be pre-heated in 110 DEG C of heating furnace, rolling heating 35s, Obtain material I;
2) Blumeae preparatum Tabellae is ground crushing, obtains material II;
3) by Cladonia alpestris (L.) Rabenh., Semen Plantaginiss, Herba Senecionis Scandentiss, Spica Prunellae, Semen Euryaless, Semen Pharbitidiss, Fructus Ligustri Lucidi, Flos Buddlejae mixing, 8 times are added The water of quality, decocts after extracting 1h, is added thereto to step 1) the uncooled material I of fresh baked, continue to decoct 1.5h, filter, Obtain filtrate;
4) filtrate is carried out concentrating under reduced pressure, obtains the clear paste that relative density is 1.05 (60 DEG C), be added thereto to material II, stir Mix uniformly, obtain mixed liquor;
5) pharmaceutically acceptable carrier is added in mixed liquor, prepare piece agent.
Embodiment 2:
A kind of Chinese medicine composition for treating glaucoma, is made up of the raw material of following weight portion:7 parts of Folium Ginkgo, Cladonia alpestris (L.) Rabenh. 8 Part, 8 parts of Semen Plantaginiss, 13 parts of the Radix Paeoniae Alba, 11 parts of Herba Senecionis Scandentiss, 13 parts of Radix et Caulis Opuntiae Dillenii, 12 parts of Spica Prunellae, 4 parts of Blumeae preparatum Tabellae, 10 parts of Semen Euryaless, lead a cow 4 parts of son, 9 parts of Fructus Ligustri Lucidi, 14 parts of Flos Buddlejae.
The preparation method of the Chinese medicine composition for the treatment of glaucoma, step are as follows:
1) Folium Ginkgo, the Radix Paeoniae Alba and Radix et Caulis Opuntiae Dillenii are crushed, adds and be pre-heated in 115 DEG C of heating furnace, rolling heating 35s, Obtain material I;
2) Blumeae preparatum Tabellae is ground crushing, obtains material II;
3) by Cladonia alpestris (L.) Rabenh., Semen Plantaginiss, Herba Senecionis Scandentiss, Spica Prunellae, Semen Euryaless, Semen Pharbitidiss, Fructus Ligustri Lucidi, Flos Buddlejae mixing, 9 times are added The water of quality, decocts after extracting 1h, is added thereto to step 1) the uncooled material I of fresh baked, continues to decoct 2h, filters, obtain Filtrate;
4) filtrate is carried out concentrating under reduced pressure, obtains the clear paste that relative density is 1.05 (60 DEG C), be added thereto to material II, stir Mix uniformly, obtain mixed liquor;
5) pharmaceutically acceptable carrier is added in mixed liquor, be prepared into decoction.
Embodiment 3:
A kind of Chinese medicine composition for treating glaucoma, is made up of the raw material of following weight portion:10 parts of Folium Ginkgo, Cladonia alpestris (L.) Rabenh. 8 Part, 8 parts of Semen Plantaginiss, 12 parts of the Radix Paeoniae Alba, 9 parts of Herba Senecionis Scandentiss, 12 parts of Radix et Caulis Opuntiae Dillenii, 12 parts of Spica Prunellae, 3 parts of Blumeae preparatum Tabellae, 9 parts of Semen Euryaless, Semen Pharbitidiss 3 Part, 8 parts of Fructus Ligustri Lucidi, 13 parts of Flos Buddlejae.
The preparation method of the Chinese medicine composition for the treatment of glaucoma, step are as follows:
1) Folium Ginkgo, the Radix Paeoniae Alba and Radix et Caulis Opuntiae Dillenii are crushed, adds and be pre-heated in 120 DEG C of heating furnace, rolling heating 30s, Obtain material I;
2) Blumeae preparatum Tabellae is ground crushing, obtains material II;
3) by Cladonia alpestris (L.) Rabenh., Semen Plantaginiss, Herba Senecionis Scandentiss, Spica Prunellae, Semen Euryaless, Semen Pharbitidiss, Fructus Ligustri Lucidi, Flos Buddlejae mixing, 8 times are added The water of quality, decocts after extracting 1h, is added thereto to step 1) the uncooled material I of fresh baked, continues to decoct 1h, filters, obtain Filtrate;
4) filtrate is carried out concentrating under reduced pressure, obtains the clear paste that relative density is 1.05 (60 DEG C), be added thereto to material II, stir Mix uniformly, obtain mixed liquor;
5) pharmaceutically acceptable carrier is added in mixed liquor, be prepared into capsule.
Embodiment 4:
A kind of Chinese medicine composition for treating glaucoma, is made up of the raw material of following weight portion:10 parts of Folium Ginkgo, Cladonia alpestris (L.) Rabenh. 5 Part, 10 parts of Semen Plantaginiss, 10 parts of the Radix Paeoniae Alba, 12 parts of Herba Senecionis Scandentiss, 10 parts of Radix et Caulis Opuntiae Dillenii, 15 parts of Spica Prunellae, 2 parts of Blumeae preparatum Tabellae, 12 parts of Semen Euryaless, lead a cow 3 parts of son, 12 parts of Fructus Ligustri Lucidi, 10 parts of Flos Buddlejae.
The preparation method of the Chinese medicine composition for the treatment of glaucoma, step are as follows:
1) Folium Ginkgo, the Radix Paeoniae Alba and Radix et Caulis Opuntiae Dillenii are crushed, adds and be pre-heated in 110 DEG C of heating furnace, rolling heating 40s, Obtain material I;
2) Blumeae preparatum Tabellae is ground crushing, obtains material II;
3) by Cladonia alpestris (L.) Rabenh., Semen Plantaginiss, Herba Senecionis Scandentiss, Spica Prunellae, Semen Euryaless, Semen Pharbitidiss, Fructus Ligustri Lucidi, Flos Buddlejae mixing, 10 are added The water of times quality, decocts after extracting 1h, is added thereto to step 1) the uncooled material I of fresh baked, continue to decoct 2h, filter, Obtain filtrate;
4) filtrate is carried out concentrating under reduced pressure, obtains the clear paste that relative density is 1.05 (60 DEG C), be added thereto to material II, stir Mix uniformly, obtain mixed liquor;
5) pharmaceutically acceptable carrier is added in mixed liquor, be prepared into pill.
Embodiment 5:
A kind of Chinese medicine composition for treating glaucoma, is made up of the raw material of following weight portion:5 parts of Folium Ginkgo, Cladonia alpestris (L.) Rabenh. 10 Part, 5 parts of Semen Plantaginiss, 15 parts of the Radix Paeoniae Alba, 7 parts of Herba Senecionis Scandentiss, 15 parts of Radix et Caulis Opuntiae Dillenii, 10 parts of Spica Prunellae, 5 parts of Blumeae preparatum Tabellae, 7 parts of Semen Euryaless, Semen Pharbitidiss 6 Part, 7 parts of Fructus Ligustri Lucidi, 15 parts of Flos Buddlejae.
The preparation method of the Chinese medicine composition for the treatment of glaucoma, with embodiment 4.
Pharmacology's detection is carried out to medicine obtained in the embodiment of the present invention, wherein, toxicity drug effect reality is carried out using white mice Test, do not find obvious toxic and side effects, illustrate that safety of medicine prepared by the embodiment of the present invention has no toxic side effect.The medicine that will be prepared Clinic is further applied, through clinical drug best results prepared by Clinical detection, embodiment 1.
Clinical case:
Case selection:The glaucoma patient 100 that makes a definite diagnosis, wherein male 56, women 44 is selected, the age is in 35-70 Between year, the mean age, before patient's medication, in more than 30mmHg, fluctuation range was more than intraocular pressure meansigma methodss within 24 hours at 46 years old 8mmHg.
1st, diagnostic criteria:Recurrent exerbation visual deterioration (still declines containing Postoperative visual acuity or open angle glaucoma visual deterioration is slow Slowly, non-evident sympton patient) sometimes eye pain, ictal iridization, platycoria, intraocular pressure 32-75mmHg, optic atrophy, repeatedly Outbreak is blind to be less than 1 month.
2nd, Therapeutic Method:The Chinese medicinal tablet prepared using the embodiment of the present invention 1,2g/ pieces, 2 times a day, 2 every time, warm water Take, be within 7 days 1 course for the treatment of, treatment cycle is 3 courses for the treatment of.
3rd, Outcome measure
Effective:Intraocular pressure control all disappears in below 21mmHg, primary symptom and adjoint disease;
Effectively:Intraocular pressure control disappears in below 21mmHg, primary symptom, mitigates with disease;
Invalid:Intraocular pressure is unchanged, and simultaneous phenomenon does not change.
4th, therapeutic outcome:
After taking 3 courses for the treatment of, in 100 glaucoma patients, effective 64, effective 33, invalid 3, total effective rate reaches 97%.
Model case:
Zhang, 54 years old, suffers from glaucoma and has 3 years, and intraocular pressure is sometime up to 50mmHg, and fluctuation range is more than within 24 hours 12mmHg, eyeball distending pain, platycoria, after taking 3 courses for the treatment of of medicine of the embodiment of the present invention 1, eyeball distending pain disappears, follow-up one Year does not recur.
It should be noted that herein, such as first and second or the like relational terms are used merely to a reality Body or operation are made a distinction with another entity or operation, and are not necessarily required or implied these entities or deposit between operating In any this actual relation or order.And, term " including ", "comprising" or its any other variant are intended to Nonexcludability includes, so that a series of process, method, article or equipment including key elements not only includes that those will Element, but also other key elements including being not expressly set out, or also include for this process, method, article or equipment Intrinsic key element.In the absence of more restrictions, the key element for being limited by sentence "including a ...", it is not excluded that Also there is other identical element in process, method, article or equipment including the key element.
Above example only in order to technical scheme to be described, rather than a limitation;Although with reference to the foregoing embodiments The present invention has been described in detail, it will be understood by those within the art that:Which still can be to aforementioned each enforcement Technical scheme described in example is modified, or carries out equivalent to which part technical characteristic;And these modification or Replace, do not make the essence of appropriate technical solution depart from the spirit and scope of various embodiments of the present invention technical scheme.

Claims (5)

1. a kind of Chinese medicine composition for treating glaucoma, it is characterised in that be made up of the raw material of following weight portion:Folium Ginkgo 5-10 Part, Cladonia alpestris (L.) Rabenh. 5-10 parts, Semen Plantaginiss 5-10 parts, Radix Paeoniae Alba 10-15 parts, Herba Senecionis Scandentiss 7-12 parts, Radix et Caulis Opuntiae Dillenii 10-15 parts, Spica Prunellae 10- 15 parts, Blumeae preparatum Tabellae 2-5 parts, Semen Euryaless 7-12 parts, Semen Pharbitidiss 3-6 parts, Fructus Ligustri Lucidi 7-12 parts, Flos Buddlejae 10-15 parts.
2. as claimed in claim 1 treatment glaucoma Chinese medicine composition, it is characterised in that by the raw material group of following weight portion Into:8 parts of Folium Ginkgo, 7 parts of Cladonia alpestris (L.) Rabenh., 8 parts of Semen Plantaginiss, 11 parts of the Radix Paeoniae Alba, 10 parts of Herba Senecionis Scandentiss, 12 parts of Radix et Caulis Opuntiae Dillenii, 11 parts of Spica Prunellae, Chinese mugwort 4 parts of piece, 10 parts of Semen Euryaless, 5 parts of Semen Pharbitidiss, 10 parts of Fructus Ligustri Lucidi, 12 parts of Flos Buddlejae.
3. as claimed in claim 1 treatment glaucoma Chinese medicine composition, it is characterised in that by the raw material group of following weight portion Into:7 parts of Folium Ginkgo, 8 parts of Cladonia alpestris (L.) Rabenh., 8 parts of Semen Plantaginiss, 13 parts of the Radix Paeoniae Alba, 11 parts of Herba Senecionis Scandentiss, 13 parts of Radix et Caulis Opuntiae Dillenii, 12 parts of Spica Prunellae, Chinese mugwort 4 parts of piece, 10 parts of Semen Euryaless, 4 parts of Semen Pharbitidiss, 9 parts of Fructus Ligustri Lucidi, 14 parts of Flos Buddlejae.
4. as described in claim 1-3 is arbitrary treatment glaucoma Chinese medicine composition preparation method, it is characterised in that step As follows:
1) Folium Ginkgo, the Radix Paeoniae Alba and Radix et Caulis Opuntiae Dillenii are crushed, adds and be pre-heated in 110-120 DEG C of heating furnace, rolling heating 30- 40s, obtains material I;
2) Blumeae preparatum Tabellae is ground crushing, obtains material II;
3) by Cladonia alpestris (L.) Rabenh., Semen Plantaginiss, Herba Senecionis Scandentiss, Spica Prunellae, Semen Euryaless, Semen Pharbitidiss, Fructus Ligustri Lucidi, Flos Buddlejae mixing, 8-10 times is added The water of quality, decocts after extracting 1h, is added thereto to step 1) the uncooled material I of fresh baked, continue to decoct 1-2h, filter, Obtain filtrate;
4) filtrate is carried out concentrating under reduced pressure, obtains the clear paste that relative density is 1.05 (60 DEG C), be added thereto to material II, stirring is Even, obtain mixed liquor;
5) pharmaceutically acceptable carrier is added in mixed liquor, be prepared into corresponding pharmaceutical dosage form.
5. the preparation method of the Chinese medicine composition for the treatment of glaucoma as claimed in claim 4, it is characterised in that the dosage form is Tablet, granule, decoction, capsule or pill.
CN201710002663.0A 2017-01-03 2017-01-03 A kind of treat Chinese medicine composition of glaucoma and preparation method thereof Pending CN106491730A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108175818A (en) * 2018-03-07 2018-06-19 黑龙江中医药大学 A kind of Chinese medicine composition for treating glaucoma and its preparation method and application

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104398543A (en) * 2014-12-05 2015-03-11 上海信谊百路达药业有限公司 Application of folium ginkgo composition to preparation of medicine for preventing or treating glaucoma

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104398543A (en) * 2014-12-05 2015-03-11 上海信谊百路达药业有限公司 Application of folium ginkgo composition to preparation of medicine for preventing or treating glaucoma

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
谭浅等: ""三子加明汤对急性高眼压兔视网膜保护作用的实验研究"", 《湖南中医学院学报》 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108175818A (en) * 2018-03-07 2018-06-19 黑龙江中医药大学 A kind of Chinese medicine composition for treating glaucoma and its preparation method and application
CN108175818B (en) * 2018-03-07 2020-12-22 黑龙江中医药大学 Traditional Chinese medicine composition for treating glaucoma and preparation method and application thereof

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Application publication date: 20170315