CN112245493A - Eye-protecting health-care patch and preparation method thereof - Google Patents

Eye-protecting health-care patch and preparation method thereof Download PDF

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Publication number
CN112245493A
CN112245493A CN202011104671.4A CN202011104671A CN112245493A CN 112245493 A CN112245493 A CN 112245493A CN 202011104671 A CN202011104671 A CN 202011104671A CN 112245493 A CN112245493 A CN 112245493A
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parts
eye
protecting health
care patch
active ingredients
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黄承斌
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Zhengzhou Heshanmei Biotechnology Co ltd
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Zhengzhou Heshanmei Biotechnology Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/56—Loganiaceae (Logania family), e.g. trumpetflower or pinkroot
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/11—Pteridophyta or Filicophyta (ferns)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/238—Saposhnikovia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/286—Carthamus (distaff thistle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/287—Chrysanthemum, e.g. daisy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/534—Mentha (mint)
    • A—HUMAN NECESSITIES
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/536—Prunella or Brunella (selfheal)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537—Salvia (sage)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
    • A61K36/605—Morus (mulberry)
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/68—Plantaginaceae (Plantain Family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/718—Coptis (goldthread)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/756—Phellodendron, e.g. corktree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

Abstract

The invention provides an eye-protecting health-care patch which comprises active ingredients and absorption-promoting ingredients, wherein the active ingredients comprise the following components in parts by weight: 2-8 parts of butterflybush flower, 3-8 parts of wild chrysanthemum flower, 5-15 parts of mint, 5-12 parts of ginseng, 5-12 parts of safflower, 5-12 parts of selfheal, 2-10 parts of mulberry leaf, 4-15 parts of cassia seed, 5-15 parts of plantain seed, 1-10 parts of divaricate saposhnikovia root, 1-5 parts of salvia miltiorrhiza, 1-6 parts of coptis chinensis, 2-7 parts of golden cypress and 5-13 parts of equisetum hiemale. The invention provides an eye protection health care patch, which has mild performance, provides good protection for eye skin, increases blood flow velocity around eyes, improves eye conjunctiva microcirculation disturbance and prevents the formation of microcirculation disturbance, and effectively relieves the function of asthenopia. Finally, the eye-protecting health-care patch can obviously improve the ultrastructure of lacrimal gland tissues, stimulate lacrimal glands to increase secretion and further improve the stability of lacrimal films.

Description

Eye-protecting health-care patch and preparation method thereof
Technical Field
The invention relates to the technical field of eye care, in particular to an eye protection health care patch.
Background
With the progress of science and technology, electronic products such as mobile phones and computers cannot be used in daily life. Therefore, a series of eye diseases caused by the eye diseases directly affect the work and life of people, such as dry eyes, sour eyes, blurred vision and even vision loss. The eye diseases are mainly caused by that when people concentrate on watching screens of electronic products such as televisions, computers or mobile phones and the like at ordinary times, the eye blinking frequency is reduced, the tear secretion is correspondingly reduced, and meanwhile, the blinking screen strongly stimulates eyes. Also, careless eye care can cause redness and swelling of the capillaries on the surface of the eye and congestion of the eye, often due to insufficient oxygen supply to the cornea or other tissues on the surface of the eye.
At present, although many medicines and various researches are carried out on symptoms such as dry eyes, itching eyes, acerbity eyes, pain and the like caused by excessive asthenopia by using eyes, and some curative effects are obtained, most of the medicines are chemical medicines, and the medicines have some side effects and adverse reactions, and have health-care components with remarkable effects and small adverse reactions.
Therefore, in order to overcome the defects of the prior art, the problem to be solved by the technical personnel in the field is urgently needed to find a health care product which can relieve visual fatigue, has few side effects and high safety and has definite curative effect.
Disclosure of Invention
The eye protection health care patch is mild in performance, provides good protection for eye skin, increases blood flow speed around eyes, improves eye conjunctiva microcirculation disturbance, prevents the formation of the microcirculation disturbance, and effectively relieves the function of asthenopia. Finally, the eye-protecting health-care patch can obviously improve the ultrastructure of lacrimal gland tissues, stimulate lacrimal glands to increase secretion and further improve the stability of lacrimal films.
According to the first direction of the invention, the eye-protecting health-care patch comprises an active ingredient and an absorption-promoting ingredient, wherein the active ingredient comprises the following components in parts by weight: 2-8 parts of butterflybush flower, 3-8 parts of wild chrysanthemum flower, 5-15 parts of mint, 5-12 parts of ginseng, 5-12 parts of safflower, 5-12 parts of selfheal, 2-10 parts of mulberry leaf, 4-15 parts of cassia seed, 5-15 parts of plantain seed, 1-10 parts of divaricate saposhnikovia root, 1-5 parts of salvia miltiorrhiza, 1-6 parts of coptis chinensis, 2-7 parts of golden cypress and 5-13 parts of equisetum hiemale.
The active ingredients comprise the following components in parts by weight: 4-8 parts of butterflybush flower, 3-5 parts of wild chrysanthemum flower, 5-10 parts of mint, 5-8 parts of ginseng, 5-8 parts of safflower, 5 parts of selfheal, 4-10 parts of mulberry leaf, 4-5 parts of cassia seed, 5-10 parts of plantain seed, 1-4 parts of divaricate saposhnikovia root, 3-5 parts of salvia miltiorrhiza, 3-6 parts of coptis chinensis, 3-7 parts of golden cypress and 5-9 parts of equisetum hiemale.
In the invention, the butterflybush flower is sweet in nature and slightly cold. Meridian tropism enters liver meridian. Has effects in clearing away heat, nourishing liver, improving eyesight, and eliminating nebula, and can be used for treating conjunctival congestion, swelling and pain, lacrimation, photophobia, nebula, liver deficiency, dim eyesight, and blurred vision. The flos buddlejae, the wild chrysanthemum flower, the cassia seed and the horsetail are compatible, can obviously improve the ultrastructure of lacrimal gland tissues, maintain the basal secretion of lacrimal gland and the stability of lacrimal film, and have the functions of treating red and astringent eyes and red veins in eyes caused by excessive heat of liver channel.
Wild chrysanthemum flower, bitter in flavor, pungent and slightly cold in nature, enters liver and heart meridians. The invention has the functions of clearing away heat and toxic material and resisting oxidation, and can enhance the oxidation resistance of crystalline lens and protect the crystalline lens from oxidative damage.
The mint is pungent in flavor and cool. Enters lung and liver meridians, and has the effects of dispelling wind and heat, clearing head and eyes, relieving sore throat, promoting eruption, soothing liver and promoting qi circulation. The mint can disperse wind heat, clear head and eyes, can improve eyesight, cool and moisten eyes, and has the effect of improving eyesight by instantly feeling the vision field of eyes to be enlarged due to the cool property of the mint and the fluidity of water.
The ginseng has the functions of tonifying liver, improving eyesight and relieving fatigue; and can promote phagocytic function of reticuloendothelial cells, increase serum specific antibody concentration, promote division of T and B lymphocytes, and enhance spleen immunity. In addition, the induction of interleukin-2 can be promoted, and the activity of spleen natural killer cells can be improved.
Safflower is warm in nature and pungent in taste. The Chinese medicinal materials enter heart meridian and liver meridian, and have blood stasis dispelling and analgesic effects, and can be used for improving peripheral microcirculation disturbance, directly contracting blood vessel, and relieving pain.
Spica Prunellae is pungent, bitter and cold. It enters liver and gallbladder meridians. Has the effects of clearing away fire, improving eyesight, eliminating stagnation, and relieving swelling. The combination of wild chrysanthemum flower and cassia seed in the invention can clear liver fire, and is the essential medicine for treating conjunctival congestion, headache and dizziness caused by liver fire flaming up.
Mulberry leaves are sweet, bitter and cold in nature and taste. Meridian tropism enters lung and liver meridians. Has effects of dispelling pathogenic wind and heat, clearing lung-heat, moistening dryness, removing liver fire, and improving eyesight. It can be used in combination with flos Chrysanthemi Indici, herba Menthae, radix Platycodi, etc. for treating conjunctival congestion and photophobia caused by wind-heat, clearing liver fire, and conjunctival congestion and swelling and pain caused by liver fire flaming, and can be used in combination with flos Chrysanthemi, semen Cassiae, and semen plantaginis.
Cassia seed, semen Cassiae, is sweet, bitter, salty and slightly cold in nature and taste. The meridian tropism enters liver and large intestine meridians, and has the effects of clearing heat, improving eyesight, moistening intestines and relaxing bowels. It is used for blood-shot eyes with pain, photophobia with lacrimation, headache with dizziness, dim eyes with no vision, and it can clear away stagnated fire of liver and gallbladder and dispel wind-heat, such as Huang Qin and Xia Ku Cao.
Plantain seed, semen plantaginis is sweet in nature and flavor and slightly cold in nature. Meridian tropism enters liver, kidney, lung and small intestine meridians. The functions are mainly used for clearing heat and promoting urination, excreting dampness and treating stranguria, improving eyesight and eliminating phlegm. It is combined with Ju Hua and Jue Ming Zi for blood-shot eyes with swelling and pain or dim eyes with flower, such as blood-shot eyes with swelling and pain due to up-flaming of liver fire.
Wind-proof, pungent, sweet and warm in flavor. Meridian tropism is classified into bladder, liver and spleen meridians. It is slightly warm but not dry, so it is also indicated for wind-heat abscess, red eyes with swelling and pain, and throat discomfort, and can be used with Jing Jie, Bo He, Lian Qiao, shan Zhi and Huang Qin.
Dan Shen is bitter in flavor and slightly cold in nature. It enters heart and liver meridians. Has the functions of removing blood stasis and relieving pain. The Chinese angelica and the borneol are compatible, and the effects of dredging orifices, dissipating stagnated fire, removing nebula and improving eyesight, and relieving swelling and pain of the borneol are increased.
Huang Lian is bitter in flavor and cold in nature. The meridian entered heart, spleen, stomach, liver, gallbladder and large intestine. The functions are mainly used for clearing heat and drying dampness, purging fire and removing toxicity, and the externally used coptis root juice for eye drop can treat exuberance of fire and red eyes. The radix scutellariae can be used for effectively treating conjunctival congestion caused by hyperactivity of heart-fire.
Phellodendron bark, cortex Phellodendri, is bitter in nature and cold in taste. Meridian tropism enters kidney and bladder meridians. The functions are mainly used for clearing heat and drying dampness, purging fire and removing steam, detoxifying and treating sore, and the scutellaria baicalensis and the coptis chinensis are used for assisting in clearing heat and drying dampness.
Horsetail is sweet, bitter and neutral in nature. Meridian tropism enters lung and liver meridians. The medicine has the functions of dispelling wind heat and eliminating nebula.
In the invention, the compatibility of the butterflybush flower, the wild chrysanthemum flower, the cassia seed and the horsetail can obviously improve the ultrastructure of lacrimal gland tissues, maintain the basal secretion of the lacrimal gland and the stability of a lacrimal film, and have the functions of treating red and astringent eyes and red veins in eyes caused by excessive heat of liver channel. Meanwhile, the ginseng and the safflower have obvious direct contraction effect on blood vessels for improving peripheral microcirculation disturbance; obviously improve the anoxic environment and improve the immune function of eyes at the same time; the mulberry leaf, the plantain seed and the selfheal can clear stagnated fire of liver and gallbladder by being combined with the medicine; the coptis, the phellodendron and the divaricate saposhnikovia root can moderate the property of the medicine and clear liver fire, and the heart fire has the functions of dissipating wind heat, clearing heat and drying dampness; the red sage root is mainly compatible with the absorption promoting component, so that the skin compliance of the absorption promoting component is further improved, and the absorption is convenient.
Further, the absorption promoting component comprises the following components in parts by weight: 80-120 parts of pearl powder, 3-8 parts of blueberry extract, 2-8 parts of lutein, 10-20 parts of menthol, 2-10 parts of borneol, 30-40 parts of sodium benzoate and 2-7 parts of glycerol.
Further, the absorption promoting component comprises the following components in parts by weight: 100-120 parts of pearl powder, 3-5 parts of blueberry extract, 2-5 parts of lutein, 10-15 parts of menthol, 8-10 parts of borneol, 30-35 parts of sodium benzoate and 5-7 parts of glycerol.
The pearl hydrolysate can dredge microcirculation, increase the number of capillary vessel intersections of the conjunctiva of the eyeball, increase the blood flow speed, improve the microcirculation disturbance of the conjunctiva of the eyeball and prevent the formation of the microcirculation disturbance.
The extraction method of the blueberry extract utilizes the conventional method for extracting blueberry anthocyanin at present to carry out extraction, namely: crushing and extracting the blueberries and the extracting solution in a flash extractor, and filtering to obtain the extracting solution; mixing the extractive solution with oil phase, extracting, and separating to obtain oil phase and water phase; mixing the oil phase with the citric acid extract for back extraction to obtain an extracted water phase; mixing the water phase and the extracted water phase, separating by using a membrane separation method to obtain anthocyanin filtrate, concentrating the anthocyanin filtrate, and drying to obtain the anthocyanin and the multiple vitamins.
The blueberry extract with the absorption promoting components mainly contains anthocyanin and multiple vitamins, and can be kept as an acidic solution, so that the anthocyanin is more stable, the blood circulation of eyes can be increased, the effect of protecting the eyes can be realized, and the blood circulation of the eyes can be increased.
The absorption promoting component has obvious effect, can greatly improve the compliance of eye skin, and can obviously promote the absorption of active components. In addition, the composition has universality, can not cause allergy to skin of eyes, and can not influence the effect of the original formula; and the absorption promoting component and the active component are combined to have the effects of enhancing skin absorption and strengthening and relieving eye fatigue.
According to a second object of the invention, a method for preparing an eye-protecting health-care patch is provided, which comprises the following steps:
(1) soaking the active ingredients respectively to remove surface impurities, and pulverizing; extracting with water for 2-3 times, mixing extractive solutions, sterilizing, and filtering;
(2) carrying out alcohol precipitation on the extracting solution obtained in the step (1) by using 95% ethanol to ensure that the alcohol precipitation concentration is 60% -70%, and evaporating to remove the ethanol; obtaining phase A;
(3) extracting Margarita powder with water for 2-3 times, and mixing filtrates to obtain Margarita powder water extractive solution; adding fructus Myrtilli extract, xanthophyll, Mentholum, Borneolum Syntheticum, sodium benzoate and glycerol to obtain phase B;
(4) mixing the phase A and the phase B, adding a proper amount of triethanolamine to adjust the pH value to 5-6, finally adding deionized water to a gel state, uniformly coating the gel state on a crescent non-woven fabric backing material, covering an anti-sticking layer, and properly pressurizing a heating layer to obtain the eye mask.
Preferably, the combined extracts are sterile filtered in step (1) using a 0.2 micron filter.
Preferably, in the step (2), alcohol precipitation is used for removing grease on the surface of the extracting solution, and activated carbon is used for decoloring to obtain an alcohol extracting solution; distilling and recovering ethanol until the concentrated ethanol extract has no alcohol smell, adding deionized water with the same volume into the concentrated ethanol extract, and removing the bottom precipitate to obtain phase A.
Preferably, the combined extracts are sterile filtered in step (1) using a 0.2 micron filter.
Preferably, the heating layer added in the step (3) can heat the skin around the eyes when the eye patch is used, so that the eye patch is more beneficial to absorption.
The preparation method of the traditional Chinese medicine composition provided by the invention extracts various components with pharmacological effects by adopting different processing methods aiming at different components on the basis of comprehensively considering the medicinal properties of the raw materials in the formula, combines a specific preparation method, and realizes the effects of increasing the blood flow speed around eyes, improving the micro-circulatory disturbance of the conjunctiva of the eyeball and preventing the formation of the micro-circulatory disturbance, further stimulating the lacrimal gland to increase the secretion amount and effectively relieving the asthenopia.
Through the technical scheme, the invention provides an eye protection health care patch, which has the following advantages:
the invention provides an eye protection health care patch, which has mild performance, provides good protection for eye skin, increases blood flow velocity around eyes, improves eye conjunctiva microcirculation disturbance and prevents the formation of microcirculation disturbance, and effectively relieves the function of asthenopia. The eye-protecting health-care patch can obviously improve the ultrastructure of lacrimal gland tissues, stimulate lacrimal glands to increase secretion and further improve the stability of lacrimal films. The traditional Chinese medicine composition for eye protection and health care is prepared from pure traditional Chinese medicines, has high safety and good comfort, and can play a double role in improving visual fatigue and skin conditions around eyes. Finally, the traditional Chinese medicine composition is a uniform gel-like substance, and is convenient to store and use.
Detailed Description
In order that the above objects, features and advantages of the present invention can be more clearly understood, the present invention will be described in further detail with reference to specific embodiments. It should be noted that the embodiments of the present invention and features of the embodiments may be combined with each other without conflict.
In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present invention, however, the present invention may be practiced in other ways than those specifically described herein, and therefore the scope of the present invention is not limited by the specific embodiments disclosed below.
Example 1
An eye-protecting health-care patch comprises active ingredients and absorption-promoting ingredients, wherein the active ingredients comprise the following components in parts by weight: 2-8 parts of butterflybush flower, 3-8 parts of wild chrysanthemum flower, 5-15 parts of mint, 5-12 parts of ginseng, 5-12 parts of safflower, 5-12 parts of selfheal, 2-10 parts of mulberry leaf, 4-15 parts of cassia seed, 5-15 parts of plantain seed, 1-10 parts of divaricate saposhnikovia root, 1-5 parts of salvia miltiorrhiza, 1-6 parts of coptis chinensis, 2-7 parts of golden cypress and 5-13 parts of equisetum hiemale.
In order to further optimize the technical scheme of the invention, the active ingredients comprise the following components in parts by weight: 4-8 parts of butterflybush flower, 3-5 parts of wild chrysanthemum flower, 5-10 parts of mint, 5-8 parts of ginseng, 5-8 parts of safflower, 5 parts of selfheal, 4-10 parts of mulberry leaf, 4-5 parts of cassia seed, 5-10 parts of plantain seed, 1-4 parts of divaricate saposhnikovia root, 3-5 parts of salvia miltiorrhiza, 3-6 parts of coptis chinensis, 3-7 parts of golden cypress and 5-9 parts of equisetum hiemale.
In order to further optimize the technical scheme of the invention, the absorption promoting component comprises the following components in parts by weight: 80-120 parts of pearl powder, 3-8 parts of blueberry extract, 2-8 parts of lutein, 10-20 parts of menthol, 2-10 parts of borneol, 30-40 parts of sodium benzoate and 2-7 parts of glycerol.
In order to further optimize the technical scheme of the invention, the absorption promoting component comprises the following components in parts by weight: 100-120 parts of pearl powder, 3-5 parts of blueberry extract, 2-5 parts of lutein, 10-15 parts of menthol, 8-10 parts of borneol, 30-35 parts of sodium benzoate and 5-7 parts of glycerol.
The method for preparing the eye-protecting health-care patch comprises the following steps:
(1) soaking the active ingredients for 30-60min, removing surface impurities, and pulverizing; extracting with water for 2-3 times, mixing extractive solutions, and sterilizing with 0.2 μm filter membrane;
(2) carrying out alcohol precipitation on the extracting solution obtained in the step (1) by using 95% ethanol to ensure that the alcohol precipitation concentration is 60% -70%, removing grease on the surface of the extracting solution by using the alcohol precipitation, and decoloring by using active carbon to obtain an alcohol extracting solution; distilling and recovering ethanol until the concentrated ethanol extract has no alcohol smell, adding deionized water with the same volume into the concentrated ethanol extract, and removing bottom precipitate to obtain phase A;
(3) extracting Margarita powder with water for 2-3 times, and mixing filtrates to obtain Margarita powder water extractive solution; adding fructus Myrtilli extract, xanthophyll, Mentholum, Borneolum Syntheticum, sodium benzoate and glycerol to obtain phase B;
(4) and mixing the phase A and the phase B, adding a proper amount of triethanolamine to adjust the pH value to 5-6, finally adding deionized water to a gel state, uniformly coating the gel state on a crescent non-woven fabric backing material, covering an anti-sticking layer and a heating layer, and properly pressurizing to obtain the eye mask.
Example 2
An eye-protecting health-care patch comprises active ingredients and absorption-promoting ingredients, wherein the active ingredients comprise the following components in parts by weight: 4 parts of butterflybush flower, 5 parts of wild chrysanthemum flower, 10 parts of mint, 8 parts of ginseng, 8 parts of safflower, 5 parts of selfheal, 4 parts of mulberry leaf, 5 parts of cassia seed, 10 parts of plantain seed, 4 parts of divaricate saposhnikovia root, 3 parts of salvia miltiorrhiza, 3 parts of coptis chinensis, 3 parts of golden cypress and 9 parts of equisetum hiemale.
The absorption promoting component comprises the following components in parts by weight: 100 parts of pearl powder, 5 parts of blueberry extract, 5 parts of lutein, 15 parts of menthol, 8 parts of borneol, 35 parts of sodium benzoate and 5 parts of glycerol.
The method for preparing the eye-protecting health-care patch comprises the following steps:
(1) soaking the active ingredients for 30min, removing surface impurities, and pulverizing; extracting with water for 3 times, mixing extractive solutions, and sterilizing with 0.2 μm filter membrane;
(2) carrying out alcohol precipitation on the extracting solution obtained in the step (1) by using 95% ethanol to ensure that the alcohol precipitation concentration is 65%, removing grease on the surface of the extracting solution by using the alcohol precipitation, and decoloring by using active carbon to obtain an alcohol extracting solution; distilling and recovering ethanol until the concentrated ethanol extract has no alcohol smell, adding deionized water with the same volume into the concentrated ethanol extract, and removing bottom precipitate to obtain phase A;
(3) extracting Margarita powder with water for 3 times, and mixing filtrates to obtain Margarita powder water extractive solution; adding fructus Myrtilli extract, xanthophyll, Mentholum, Borneolum Syntheticum, sodium benzoate and glycerol to obtain phase B;
(4) mixing the A phase and the B phase, adding a proper amount of triethanolamine to adjust the pH value to 5.5, finally adding deionized water to a gel state, uniformly coating the gel state on a crescent non-woven fabric backing material, covering an anti-sticking layer and a heating layer, and properly pressurizing to obtain the eye patch.
Example 3
The eye-protecting health-care patch in the embodiment comprises an active ingredient and an absorption-promoting ingredient, wherein the active ingredient comprises the following components in parts by weight: 6 parts of butterflybush flower, 6 parts of wild chrysanthemum flower, 5 parts of mint, 10 parts of ginseng, 6 parts of safflower, 10 parts of selfheal, 2 parts of mulberry leaf, 10 parts of cassia seed, 12 parts of plantain seed, 8 parts of divaricate saposhnikovia root, 1 part of salvia miltiorrhiza, 5 parts of coptis chinensis, 7 parts of phellodendron and 8 parts of equisetum.
The absorption promoting component comprises the following components in parts by weight: 110 parts of pearl powder, 3 parts of blueberry extract, 8 parts of lutein, 12 parts of menthol, 2 parts of borneol, 33 parts of sodium benzoate and 3 parts of glycerol.
The method for preparing the eye-protecting health-care patch comprises the following steps:
(1) soaking the active ingredients for 60min, removing surface impurities, and pulverizing; extracting with water for 2 times, mixing extractive solutions, and sterilizing with 0.2 μm filter membrane;
(2) carrying out alcohol precipitation on the extracting solution obtained in the step (1) by using 95% ethanol to ensure that the alcohol precipitation concentration is 70%, removing grease on the surface of the extracting solution by using the alcohol precipitation, and decoloring by using active carbon to obtain an alcohol extracting solution; distilling and recovering ethanol until the concentrated ethanol extract has no alcohol smell, adding deionized water with the same volume into the concentrated ethanol extract, and removing bottom precipitate to obtain phase A;
(3) extracting Margarita powder with water for 2 times, and mixing filtrates to obtain Margarita powder water extractive solution; adding fructus Myrtilli extract, xanthophyll, Mentholum, Borneolum Syntheticum, sodium benzoate and glycerol to obtain phase B;
(4) mixing the A phase and the B phase, adding a proper amount of triethanolamine to adjust the pH value to 6, finally adding deionized water to a gel state, uniformly coating the gel state on a crescent non-woven fabric backing material, covering an anti-sticking layer and a heating layer, and properly pressurizing to obtain the eye mask.
Example 4
The eye-protecting health-care patch in the embodiment comprises an active ingredient and an absorption-promoting ingredient, wherein the active ingredient comprises the following components in parts by weight: 8 parts of butterflybush flower, 3 parts of wild chrysanthemum flower, 12 parts of mint, 10 parts of ginseng, 12 parts of safflower, 6 parts of selfheal, 8 parts of mulberry leaf, 4 parts of cassia seed, 5 parts of plantain seed, 1 part of divaricate saposhnikovia root, 2 parts of salvia miltiorrhiza, 6 parts of coptis chinensis, 2 parts of phellodendron and 5 parts of equisetum.
The absorption promoting component comprises the following components in parts by weight: 120 parts of pearl powder, 7 parts of blueberry extract, 2 parts of lutein, 10 parts of menthol, 4 parts of borneol, 30 parts of sodium benzoate and 2 parts of glycerol.
The method for preparing the eye-protecting health-care patch comprises the following steps:
(1) soaking the active ingredients for 45min, removing surface impurities, and pulverizing; extracting with water for 2 times, mixing extractive solutions, and sterilizing with 0.2 μm filter membrane;
(2) carrying out alcohol precipitation on the extracting solution obtained in the step (1) by using 95% ethanol to ensure that the alcohol precipitation concentration is 68%, removing grease on the surface of the extracting solution by using the alcohol precipitation, and decoloring by using activated carbon to obtain an alcohol extracting solution; distilling and recovering ethanol until the concentrated ethanol extract has no alcohol smell, adding deionized water with the same volume into the concentrated ethanol extract, and removing bottom precipitate to obtain phase A;
(3) extracting Margarita powder with water for 3 times, and mixing filtrates to obtain Margarita powder water extractive solution; adding fructus Myrtilli extract, xanthophyll, Mentholum, Borneolum Syntheticum, sodium benzoate and glycerol to obtain phase B;
(4) mixing the A phase and the B phase, adding a proper amount of triethanolamine to adjust the pH value to 58, finally adding deionized water to a gel state, uniformly coating the gel state on a crescent non-woven fabric backing material, covering an anti-sticking layer and a heating layer, and properly pressurizing to obtain the eye mask.
Example 5
The eye-protecting health-care patch in the embodiment comprises an active ingredient and an absorption-promoting ingredient, wherein the active ingredient comprises the following components in parts by weight: 2 parts of butterflybush flower, 8 parts of wild chrysanthemum flower, 15 parts of mint, 5 parts of ginseng, 5 parts of safflower, 12 parts of selfheal, 10 parts of mulberry leaf, 15 parts of cassia seed, 15 parts of plantain seed, 10 parts of divaricate saposhnikovia root, 5 parts of salvia miltiorrhiza, 1 part of coptis chinensis, 5 parts of golden cypress and 13 parts of equisetum hiemale.
The absorption promoting component comprises the following components in parts by weight: 80 parts of pearl powder, 8 parts of blueberry extract, 3 parts of lutein, 20 parts of menthol, 10 parts of borneol, 40 parts of sodium benzoate and 7 parts of glycerol.
Other technical features in this embodiment are the same as those in embodiment 1.
Comparative example 1
In the comparative example, the active ingredients of the eye-protecting health-care patch do not comprise buddleja officinalis, wild chrysanthemum and ginseng, and other technical characteristics are the same as those in example 1.
Comparative example 2
In the comparative example, the active ingredients of the eye-protecting health-care patch do not comprise safflower, plantain seed and selfheal, and other technical characteristics are the same as those in example 2.
Comparative example 3
In the active ingredients of the eye-protecting health-care patch in the comparative example, the coptis chinensis is 10 parts, the phellodendron bark is 1 part and the divaricate saposhnikovia root is 12 parts, and other technical characteristics are the same as those in the example 2.
Comparative example 4
In the active ingredients of the eye-protecting health-care patch in the comparative example, the mulberry leaf 15 parts and the mint 1 part are the same as those in the example 2, and other technical characteristics are the same.
Comparative example 5
In the comparative example, the absorption promoting component of the eye-protecting health-care patch does not contain blueberry extract and lutein, and other technical characteristics are the same as those in example 2.
Comparative example 6
In the comparative example, the absorption promoting component of the eye-protecting health-care patch does not comprise pearl powder and borneol, and other technical characteristics are the same as those in the example 2.
Example 6
The effect of the traditional Chinese medicine eye patch is verified as follows: 200 tested persons between 15 and 65 years old with eye discomfort (specifically eye fatigue, dry eyes, eye puckery eyes, photophobia, lacrimation and the like) symptoms are selected, 20 persons in each group respectively try the eye patches obtained in the examples 2 to 5 and the comparative examples 1 to 6 for one treatment course (the traditional Chinese medicine eye patch of the invention is used for 3 days as one treatment course and is continuously used for 3 days once a day), and the tested persons are informed of a correct use method (after eye skin is cleaned, eyes are closed, two eyes are pasted on the eyes, the eye patches are gently smoothed, the eye patches are fully contacted with the eye skin, the eye patches are kept for 15 to 20 minutes, the eyes are closed for 10 minutes after the eye patches are removed, and then the eyes are opened, so that the effect of the eye patches can be obviously observed and felt).
And (3) acquiring experimental data: before and after the traditional Chinese medicine eye patch is tried out each time, shooting the skin of the eyes by using a camera respectively, and recording the shooting time; the eye skin condition is observed and judged by a dermatologist according to the shot pictures, and the scoring standard of the eye skin condition is as follows:
score 1-severe symptoms; 2 points-there is obvious symptom; score 3-symptomatic; the symptom basically disappears in 4 points, and the symptom disappears in 5 points.
The eye comfort level is judged and scored by the tested person, and the scoring standard is as follows: 1 point-the discomfort is strong and cannot be tolerated; 2 points-can be basically tolerated; 3 min-feeling uncomfortable; 4 minutes-slight discomfort; 5 points-no obvious discomfort.
The pictures shot in the experimental process and eye comfort degree records are collected, and the effect of the traditional Chinese medicine eye patch is evaluated: the traditional Chinese medicine eye patch disclosed by the invention has the effect of improving the eye skin, namely the eye skin condition score after the eye patch is used for the last time-the eye comfort score before the eye patch is used for the first time.
The traditional Chinese medicine eye patch disclosed by the invention has the effect of improving the eye comfort, namely the eye comfort score after the eye patch is used for the last time-the eye comfort score before the eye patch is used for the first time.
The specific experimental results are shown in tables 1 and 2:
TABLE 1 Effect of eye patches on improvement of eye skin
Figure BDA0002726552910000131
Figure BDA0002726552910000141
Table 2 effect of eye patch on improvement of eye comfort
Figure BDA0002726552910000142
Figure BDA0002726552910000151
The above table contains the persons who have the right of disclaimer, and no statistics are made.
As can be seen from table 2, the eye patches in examples 5 and 6 of the present invention were less compliant to the skin.
Example 7
In vitro transdermal experimental method
Preparing rat skin: after a mouse is killed after cervical vertebra is removed, abdomen hair of the mouse is carefully removed by using a self-made depilatory cream, abdomen skin is cut off, then a small forceps is used for carefully scraping until the skin is hairless, fat and mucus tissues are carefully stripped, complete skin is selected, and normal saline is used for repeatedly washing the skin; and (5) refrigerating and storing at 0 ℃ for later use within one week.
The eye patches obtained in examples 2 to 5 and comparative examples 1 to 6 were closely attached to the stratum corneum of rat skin treated in the above-mentioned test method, and then air bubbles were removed. Then the eye patch and the mouse skin are fixed between the receiving chamber and the diffusion chamber of the Franz diffusion cell, the back lining layer of the self-made eye patch faces the diffusion chamber, and after the receiving chamber is filled with receiving liquid, air bubbles are removed. Starting the thermostatic water bath and the magnetic stirrer, setting the temperature of the water bath to 37 ℃, setting the rotating speed of the magnetic stirrer to 300r/min < -1 >, and respectively removing 2mL of receiving solution (V0) from the receiving chamber by using a syringe at the set time point, and simultaneously adding blank receiving solution with the same volume. The content of the receiving solution is measured according to the content measurement method (according to the measurement method of chrysanthemum item in the first part of Chinese pharmacopoeia [0098]2010 version), and the cumulative permeation amount and the cumulative permeation rate of the medicine components are calculated. Because the receiving liquid is continuously sampled and the blank liquid is added every time, the measured value is smaller than the real value,
therefore, the correction is made as follows:
cr Ca decav 1 Σ Ci-1/V (i 1-n)
Wherein Cr is a corrected concentration, Ca is an actually measured concentration, V1 is a sampling volume, and V is a receiving tank volume
And calculating the cumulative permeation Q ═ CrV ═ 7ml
The cumulative transmittance P is Q/A A and represents the mass of the medicinal component per eye patch
The result of using the cumulative permeation amount and the cumulative transmittance of the chlorogenic acid as indexes and respectively using normal saline, 30% ethanol normal saline and 50% ethanol normal saline as receiving solutions shows that the cumulative transmittance of the chlorogenic acid is higher when the 30% ethanol normal saline is used as the receiving solution. 30% ethanol physiological saline is selected as receiving liquid.
Wherein the mean in vitro chlorogenic acid transmission rate in examples 2-5 was 65%; while comparative examples 5-6 had an average transmission of only 35%.
Example 8
The paper towels impregnated with the solutions of examples 2 to 5 and comparative examples 1 to 6 were applied to randomly grouped rats, respectively, and the average amount of tear secretion per eye of each group of rats was measured before the experiment. Measurement of lacrimal secretion: a strip of experimental filter paper having a length and width of 35 mm. times.2 mm was bent 3mm from one end, placed in the conjunctival sac of the inner side of the lower eyelid, and the length of the filter paper soaked in the solution for 5 minutes was recorded.
Wherein the results show that the eye patches of examples 2-5 can significantly stimulate the secretion of tears in rats, wherein the eye patches of examples 2-5 stimulate the secretion of tears in rats more than those of comparative examples 5-6, and the eye patches of comparative examples 5-6 stimulate the secretion of tears in rats more than those of comparative examples 3-4; the eye patches of comparative examples 3-4 stimulated the secretion of tear fluid from rats in amounts greater than those of comparative examples 1-2.
The above is only a preferred embodiment of the present invention, and is not intended to limit the present invention, and various modifications and changes will occur to those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims (5)

1. An eye-protecting health-care patch is characterized by comprising active ingredients and absorption-promoting ingredients: the active ingredients comprise the following components in parts by weight: 2-8 parts of butterflybush flower, 3-8 parts of wild chrysanthemum flower, 5-15 parts of mint, 5-12 parts of ginseng, 5-12 parts of safflower, 5-12 parts of selfheal, 2-10 parts of mulberry leaf, 4-15 parts of cassia seed, 5-15 parts of plantain seed, 1-10 parts of divaricate saposhnikovia root, 1-5 parts of salvia miltiorrhiza, 1-6 parts of coptis chinensis, 2-7 parts of golden cypress and 5-13 parts of equisetum hiemale.
2. The eye-protecting health-care patch according to claim 1, wherein the active ingredients comprise the following components in parts by weight: 4-8 parts of butterflybush flower, 3-5 parts of wild chrysanthemum flower, 5-10 parts of mint, 5-8 parts of ginseng, 5-8 parts of safflower, 5 parts of selfheal, 4-10 parts of mulberry leaf, 4-5 parts of cassia seed, 5-10 parts of plantain seed, 1-4 parts of divaricate saposhnikovia root, 3-5 parts of salvia miltiorrhiza, 3-6 parts of coptis chinensis, 3-7 parts of golden cypress and 5-9 parts of equisetum hiemale.
3. The eye-protecting health-care patch according to claim 1 or 2, wherein the absorption-promoting component comprises the following components in parts by weight: 80-120 parts of pearl powder, 3-8 parts of blueberry extract, 2-8 parts of lutein, 10-20 parts of menthol, 2-10 parts of borneol, 30-40 parts of sodium benzoate and 2-7 parts of glycerol.
4. The eye-protecting health-care patch according to claim 1 or 2, wherein the absorption-promoting component comprises the following components in parts by weight: 100-120 parts of pearl powder, 3-5 parts of blueberry extract, 2-5 parts of lutein, 10-15 parts of menthol, 8-10 parts of borneol, 30-35 parts of sodium benzoate and 5-7 parts of glycerol.
5. The method for preparing the eye-protecting health patch of claim 1, comprising the steps of:
(1) soaking the components in the active ingredients respectively to remove surface impurities and then crushing; extracting with water for 2-3 times, mixing extractive solutions, sterilizing, and filtering;
(2) carrying out alcohol precipitation on the extracting solution obtained in the step (1) by using 95% ethanol to ensure that the alcohol precipitation concentration is 60% -70%, and evaporating to remove the ethanol; obtaining phase A;
(3) extracting Margarita powder with water for 2-3 times, and mixing filtrates to obtain Margarita powder water extractive solution; adding fructus Myrtilli extract, xanthophyll, Mentholum, Borneolum Syntheticum, sodium benzoate and glycerol to obtain phase B;
(4) and mixing the phase A and the phase B, adjusting the pH value to 5-6, adding deionized water to a gel state, and uniformly coating the gel on a load material.
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CN113144040A (en) * 2021-03-11 2021-07-23 重庆清晰视界科技发展有限公司 Traditional Chinese medicine eye protection patch and preparation method thereof
CN113813315A (en) * 2021-08-16 2021-12-21 上海市光华中西医结合医院 Traditional Chinese medicine composition for relieving asthenopia and xerophthalmia, application thereof and prepared eye mask
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CN109528500A (en) * 2018-11-29 2019-03-29 珠海大爱科技有限公司 A kind of eye sticker composition and preparation method thereof
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CN109528500A (en) * 2018-11-29 2019-03-29 珠海大爱科技有限公司 A kind of eye sticker composition and preparation method thereof
CN109432338A (en) * 2019-01-18 2019-03-08 河南德盟医药科技有限公司 It is a kind of for the Chinese medicine composition of eyeshield health care, the preparation method of Chinese medicine composition and eye sticker
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Application publication date: 20210122