CN113144040A - Traditional Chinese medicine eye protection patch and preparation method thereof - Google Patents

Traditional Chinese medicine eye protection patch and preparation method thereof Download PDF

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Publication number
CN113144040A
CN113144040A CN202110265264.XA CN202110265264A CN113144040A CN 113144040 A CN113144040 A CN 113144040A CN 202110265264 A CN202110265264 A CN 202110265264A CN 113144040 A CN113144040 A CN 113144040A
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parts
chinese medicine
traditional chinese
eye
medicine eye
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何小兰
何成
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Chongqing Clear Vision Technology Development Co ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/482Cassia, e.g. golden shower tree
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/282Artemisia, e.g. wormwood or sagebrush
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/287Chrysanthemum, e.g. daisy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/536Prunella or Brunella (selfheal)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/63Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A61K36/638Ligustrum, e.g. Chinese privet
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/80Scrophulariaceae (Figwort family)
    • A61K36/804Rehmannia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/70Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/10Ophthalmic agents for accommodation disorders, e.g. myopia

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
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  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention discloses a traditional Chinese medicine eye-protecting plaster and a preparation method thereof, wherein the traditional Chinese medicine eye-protecting plaster comprises the following components of 11-13 parts of cassia seeds, 11-13 parts of selfheal, 7-9 parts of wild chrysanthemum flower, 2-4 parts of folium artemisiae argyi, 4-6 parts of glossy privet fruit, 4-6 parts of prepared rehmannia root, 4-6 parts of polyvinyl alcohol, 24-26 parts of ethanol water solution and 24-26 parts of deionized water. The invention belongs to the technical field of health care products, and provides a traditional Chinese medicine eye protection paste which is low in cost, has no side effect, can effectively protect eyes and prevent eye diseases, and a preparation method thereof, can relieve and prevent symptoms of eye swelling, eye blurring, vision deterioration and the like of the eyes, and reduces the phenomena of eye dryness, eye puckery and eye fatigue.

Description

Traditional Chinese medicine eye protection patch and preparation method thereof
Technical Field
The invention belongs to the technical field of health care products, and particularly relates to a traditional Chinese medicine eye protection patch and a preparation method thereof.
Background
At present, with the development of science and technology and the improvement of living standard, more and more electronic products are contacted by people, the time for playing the electronic products in daily life is longer and longer, the injury to eyes caused by playing the electronic products for a long time is large, eye problems are easily caused due to over-fatigue of eyes used for a long time, the eye problems can be treated or relieved through an operation, the success rate of the operation is high, but the price is expensive, once the eye problems fail and the risk of blindness exists, a mode for effectively protecting or preventing the eyes is needed, and therefore the incidence rate of eye diseases is reduced.
Disclosure of Invention
Aiming at the situations, in order to overcome the defects of the prior art, the invention aims to provide the traditional Chinese medicine eye protection patch which has low cost and no side effect, can effectively protect eyes and prevent eye diseases, and the preparation method thereof, can relieve and prevent symptoms of eye swelling, eye blurring, vision deterioration and the like of the eyes, and reduces the phenomena of eye dryness, eye puckery and eye fatigue.
The technical scheme adopted by the invention is as follows: a traditional Chinese medicine eye-protecting patch comprises the following components in parts by weight: 10-14 parts of cassia seed, 10-14 parts of selfheal, 6-10 parts of wild chrysanthemum flower, 1-5 parts of folium artemisiae argyi, 3-7 parts of glossy privet fruit, 3-7 parts of prepared rehmannia root, 3-7 parts of polyvinyl alcohol, 23-27 parts of ethanol water solution and 23-27 parts of deionized water.
Further, the traditional Chinese medicine eye protection paste comprises the following components in parts by weight: 11-13 parts of cassia seed, 11-13 parts of selfheal, 7-9 parts of wild chrysanthemum flower, 2-4 parts of folium artemisiae argyi, 4-6 parts of glossy privet fruit, 4-6 parts of prepared rehmannia root, 4-6 parts of polyvinyl alcohol, 24-26 parts of ethanol water solution and 24-26 parts of deionized water.
Further, the traditional Chinese medicine eye protection paste comprises the following components in parts by weight: 12 parts of cassia seed, 12 parts of selfheal, 8 parts of wild chrysanthemum flower, 3 parts of folium artemisiae argyi, 5 parts of glossy privet fruit, 5 parts of prepared rehmannia root, 5 parts of polyvinyl alcohol, 25 parts of ethanol water solution and 25 parts of deionized water.
Further, the preparation method of the traditional Chinese medicine eye protection paste comprises the following steps:
the method comprises the following steps: cleaning a vessel used for preparing the traditional Chinese medicine eye protection paste to obtain a clean vessel;
step two: weighing the components of the preparation raw materials to obtain weighed raw materials;
step three: adding the weighed raw materials into a clean vessel, adding deionized water, heating the clean vessel to 80-85 ℃, sequentially adding cassia seed, selfheal, wild chrysanthemum flower, folium artemisiae argyi, glossy privet fruit, radix rehmanniae preparata and ethanol aqueous solution, uniformly stirring, keeping the temperature for approximately 20 minutes, and then cooling to 20-23 ℃ to obtain a cooled stock solution;
step four: filtering the cooled stock solution to obtain a traditional Chinese medicine extracting solution, and discarding filter residues;
step five: adding polyvinyl alcohol into the Chinese medicinal extractive solution, stirring, and gelatinizing to obtain Chinese medicinal gel;
step six: placing the traditional Chinese medicine hydrogel into a mould, and carrying out cooling sterilization treatment to obtain a semi-finished product of the formed traditional Chinese medicine eye mask;
step seven: performing drawing sample inspection on the semi-finished product of the formed traditional Chinese medicine eye mask, and packaging and spraying codes to obtain a finished product of the traditional Chinese medicine eye mask after the semi-finished product of the formed traditional Chinese medicine eye mask is qualified;
step eight: and sampling and checking the finished product of the traditional Chinese medicine eye mask again, and handling and warehousing the qualified product to wait for sale.
After the technical scheme is adopted, the invention has the following beneficial effects: the eye protection liquid has low cost, most raw materials are traditional Chinese medicine components, so that the eye protection liquid has no side effect, can effectively protect eyes, can relieve and prevent symptoms of eye soreness, eye blurriness, eye decline and the like, reduces the phenomena of eye dryness, eye dryness and eye fatigue, and effectively prevents the injury caused by daily eye use.
Detailed Description
The technical solutions in the embodiments of the present invention are clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments; all other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Embodiment 1, a traditional Chinese medicine eye-protecting patch, which comprises the following components in parts by weight: 11 parts of cassia seed, 11 parts of selfheal, 7 parts of wild chrysanthemum flower, 2 parts of folium artemisiae argyi, 4 parts of glossy privet fruit, 4 parts of prepared rehmannia root, 4 parts of polyvinyl alcohol, 24 parts of ethanol water solution and 24 parts of deionized water;
the preparation method of the traditional Chinese medicine eye protection paste comprises the following steps:
the method comprises the following steps: cleaning a vessel used for preparing the traditional Chinese medicine eye protection paste to obtain a clean vessel;
step two: weighing the components of the preparation raw materials to obtain weighed raw materials;
step three: adding the weighed raw materials into a clean vessel, adding deionized water, heating the clean vessel to 80-85 ℃, sequentially adding cassia seed, selfheal, wild chrysanthemum flower, folium artemisiae argyi, glossy privet fruit, radix rehmanniae preparata and ethanol aqueous solution, uniformly stirring, keeping the temperature for approximately 20 minutes, and then cooling to 20-23 ℃ to obtain a cooled stock solution;
step four: filtering the cooled stock solution to obtain a traditional Chinese medicine extracting solution, and discarding filter residues;
step five: adding polyvinyl alcohol into the Chinese medicinal extractive solution, stirring, and gelatinizing to obtain Chinese medicinal gel;
step six: placing the traditional Chinese medicine hydrogel into a mould, and carrying out cooling sterilization treatment to obtain a semi-finished product of the formed traditional Chinese medicine eye mask;
step seven: performing drawing sample inspection on the semi-finished product of the formed traditional Chinese medicine eye mask, and packaging and spraying codes to obtain a finished product of the traditional Chinese medicine eye mask after the semi-finished product of the formed traditional Chinese medicine eye mask is qualified;
step eight: and sampling and checking the finished product of the traditional Chinese medicine eye mask again, and handling and warehousing the qualified product to wait for sale.
Example 2: a traditional Chinese medicine eye-protecting patch comprises the following components in parts by weight: 12 parts of cassia seed, 12 parts of selfheal, 8 parts of wild chrysanthemum flower, 3 parts of folium artemisiae argyi, 5 parts of glossy privet fruit, 5 parts of prepared rehmannia root, 5 parts of polyvinyl alcohol, 25 parts of ethanol water solution and 25 parts of deionized water;
the preparation method of the traditional Chinese medicine eye protection paste comprises the following steps:
the method comprises the following steps: cleaning a vessel used for preparing the traditional Chinese medicine eye protection paste to obtain a clean vessel;
step two: weighing the components of the preparation raw materials to obtain weighed raw materials;
step three: adding the weighed raw materials into a clean vessel, adding deionized water, heating the clean vessel to 80-85 ℃, sequentially adding cassia seed, selfheal, wild chrysanthemum flower, folium artemisiae argyi, glossy privet fruit, radix rehmanniae preparata and ethanol aqueous solution, uniformly stirring, keeping the temperature for approximately 20 minutes, and then cooling to 20-23 ℃ to obtain a cooled stock solution;
step four: filtering the cooled stock solution to obtain a traditional Chinese medicine extracting solution, and discarding filter residues;
step five: adding polyvinyl alcohol into the Chinese medicinal extractive solution, stirring, and gelatinizing to obtain Chinese medicinal gel;
step six: placing the traditional Chinese medicine hydrogel into a mould, and carrying out cooling sterilization treatment to obtain a semi-finished product of the formed traditional Chinese medicine eye mask;
step seven: performing drawing sample inspection on the semi-finished product of the formed traditional Chinese medicine eye mask, and packaging and spraying codes to obtain a finished product of the traditional Chinese medicine eye mask after the semi-finished product of the formed traditional Chinese medicine eye mask is qualified;
step eight: and sampling and checking the finished product of the traditional Chinese medicine eye mask again, and handling and warehousing the qualified product to wait for sale.
Example 3: a traditional Chinese medicine eye-protecting patch comprises the following components in parts by weight: 13 parts of cassia seed, 13 parts of selfheal, 9 parts of wild chrysanthemum flower, 4 parts of folium artemisiae argyi, 6 parts of glossy privet fruit, 6 parts of prepared rehmannia root, 6 parts of polyvinyl alcohol, 26 parts of ethanol aqueous solution and 26 parts of deionized water;
the preparation method of the traditional Chinese medicine eye protection paste comprises the following steps:
the method comprises the following steps: cleaning a vessel used for preparing the traditional Chinese medicine eye protection paste to obtain a clean vessel;
step two: weighing the components of the preparation raw materials to obtain weighed raw materials;
step three: adding the weighed raw materials into a clean vessel, adding deionized water, heating the clean vessel to 80-85 ℃, sequentially adding cassia seed, selfheal, wild chrysanthemum flower, folium artemisiae argyi, glossy privet fruit, radix rehmanniae preparata and ethanol aqueous solution, uniformly stirring, keeping the temperature for approximately 20 minutes, and then cooling to 20-23 ℃ to obtain a cooled stock solution;
step four: filtering the cooled stock solution to obtain a traditional Chinese medicine extracting solution, and discarding filter residues;
step five: adding polyvinyl alcohol into the Chinese medicinal extractive solution, stirring, and gelatinizing to obtain Chinese medicinal gel;
step six: placing the traditional Chinese medicine hydrogel into a mould, and carrying out cooling sterilization treatment to obtain a semi-finished product of the formed traditional Chinese medicine eye mask;
step seven: performing drawing sample inspection on the semi-finished product of the formed traditional Chinese medicine eye mask, and packaging and spraying codes to obtain a finished product of the traditional Chinese medicine eye mask after the semi-finished product of the formed traditional Chinese medicine eye mask is qualified;
step eight: and sampling and checking the finished product of the traditional Chinese medicine eye mask again, and handling and warehousing the qualified product to wait for sale.
It is noted that, herein, relational terms such as first and second, and the like may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
The present invention and its embodiments have been described above, but the description is not limitative, and the actual structure is not limited thereto. In summary, those skilled in the art should appreciate that they can readily use the disclosed conception and specific embodiments as a basis for designing or modifying other structures for carrying out the same purposes of the present invention without departing from the spirit and scope of the invention as defined by the appended claims.

Claims (4)

1. The traditional Chinese medicine eye protection paste is characterized by comprising the following components in parts by weight: 10-14 parts of cassia seed, 10-14 parts of selfheal, 6-10 parts of wild chrysanthemum flower, 1-5 parts of folium artemisiae argyi, 3-7 parts of glossy privet fruit, 3-7 parts of prepared rehmannia root, 3-7 parts of polyvinyl alcohol, 23-27 parts of ethanol water solution and 23-27 parts of deionized water.
2. The traditional Chinese medicine eye protection patch according to claim 1, which is characterized by comprising the following components in parts by weight: 11-13 parts of cassia seed, 11-13 parts of selfheal, 7-9 parts of wild chrysanthemum flower, 2-4 parts of folium artemisiae argyi, 4-6 parts of glossy privet fruit, 4-6 parts of prepared rehmannia root, 4-6 parts of polyvinyl alcohol, 24-26 parts of ethanol water solution and 24-26 parts of deionized water.
3. The traditional Chinese medicine eye protection patch according to claim 2, which is characterized by comprising the following components in parts by weight: 12 parts of cassia seed, 12 parts of selfheal, 8 parts of wild chrysanthemum flower, 3 parts of folium artemisiae argyi, 5 parts of glossy privet fruit, 5 parts of prepared rehmannia root, 5 parts of polyvinyl alcohol, 25 parts of ethanol water solution and 25 parts of deionized water.
4. The preparation method of the traditional Chinese medicine eye protection patch according to claims 1-3, which is characterized by comprising the following steps:
the method comprises the following steps: cleaning a vessel used for preparing the traditional Chinese medicine eye protection paste to obtain a clean vessel;
step two: weighing the components of the preparation raw materials to obtain weighed raw materials;
step three: adding the weighed raw materials into a clean vessel, adding deionized water, heating the clean vessel to 80-85 ℃, sequentially adding cassia seed, selfheal, wild chrysanthemum flower, folium artemisiae argyi, glossy privet fruit, radix rehmanniae preparata and ethanol aqueous solution, uniformly stirring, keeping the temperature for approximately 20 minutes, and then cooling to 20-23 ℃ to obtain a cooled stock solution;
step four: filtering the cooled stock solution to obtain a traditional Chinese medicine extracting solution, and discarding filter residues;
step five: adding polyvinyl alcohol into the Chinese medicinal extractive solution, stirring, and gelatinizing to obtain Chinese medicinal gel;
step six: placing the traditional Chinese medicine hydrogel into a mould, and carrying out cooling sterilization treatment to obtain a semi-finished product of the formed traditional Chinese medicine eye mask;
step seven: performing drawing sample inspection on the semi-finished product of the formed traditional Chinese medicine eye mask, and packaging and spraying codes to obtain a finished product of the traditional Chinese medicine eye mask after the semi-finished product of the formed traditional Chinese medicine eye mask is qualified;
step eight: and sampling and checking the finished product of the traditional Chinese medicine eye mask again, and handling and warehousing the qualified product to wait for sale.
CN202110265264.XA 2021-03-11 2021-03-11 Traditional Chinese medicine eye protection patch and preparation method thereof Pending CN113144040A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114209780A (en) * 2022-01-25 2022-03-22 郑州和善美生物科技有限公司 Method for extracting effective components of Chinese medicinal materials by biological fermentation

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Publication number Priority date Publication date Assignee Title
CN107551031A (en) * 2017-09-20 2018-01-09 杜铭 A kind of Chinese medicine composition for alleviating kopiopia, include its eye sticker and preparation method
CN112245493A (en) * 2020-10-15 2021-01-22 郑州和善美生物科技有限公司 Eye-protecting health-care patch and preparation method thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107551031A (en) * 2017-09-20 2018-01-09 杜铭 A kind of Chinese medicine composition for alleviating kopiopia, include its eye sticker and preparation method
CN112245493A (en) * 2020-10-15 2021-01-22 郑州和善美生物科技有限公司 Eye-protecting health-care patch and preparation method thereof

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114209780A (en) * 2022-01-25 2022-03-22 郑州和善美生物科技有限公司 Method for extracting effective components of Chinese medicinal materials by biological fermentation

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Application publication date: 20210723